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https://www.readbyqxmd.com/read/29684699/support-media-can-steer-methanogenesis-in-the-presence-of-phenol-through-biotic-and-abiotic-effects
#1
Simon Poirier, Sébastien Déjean, Olivier Chapleur
A wide variety of inhibitors can induce anaerobic digester disruption. To avoid performance losses, support media can be used to mitigate inhibitions. However, distinguishing the physico-chemical from the biological mechanisms of such strategies remains delicate. In this framework, the impact of 10  g/L of different types of zeolites and activated carbons (AC) on microbial community dynamics during anaerobic digestion of biowaste in the presence of 1.3 g/L of phenol was evaluated with 16 S rRNA gene sequencing...
April 13, 2018: Water Research
https://www.readbyqxmd.com/read/29684666/systematic-review-of-preservation-solutions-for-allografts-for-liver-transplantation-based-on-a-network-meta-analysis
#2
REVIEW
Fengying Rao, Jian Yang, Cheng Gong, Rong Huang, Qi Wang, Jun Shen
AIMS: The aim of this work was to determine the best preservation solutions for allografts for liver transplantation by quantitative network meta-analysis. METHODS: Global electronic databases including PubMed, EMBASE, and Cochrane Library were searched for relevant randomized controlled trials. Seven pieces of parametric data were extracted from included studies for pooled estimation. A consistency model was used for direct and indirect comparisons. The cumulative probability P value was utilized to rank the solutions...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684604/effect-of-antiaggregants-on-the-in-vitro-viability-cell-count-and-stability-of-abalone-haliotis-iris-haemocytes
#3
Roffi Grandiosa, Mai-Louise Bouwman, Tim Young, Fabrice Mérien, Andrea C Alfaro
The ability to successfully prepare and preserve haemocyte cells for microscopy and flow cytometry is critical for the investigation of animal immune systems. In this study, we observed the total cell count, in vitro viability and stability of New Zealand black-footed abalone (Haliotis iris) haemocytes with different antiaggregants and handling protocols. Haemocyte stability was evaluated by direct observation of haemocytes under the microscope and calculating the aggregation index. Haemocyte counts and viability were measured via flow cytometry and tested for the effect of different antiaggregants (Alsever's solution at three concentrations, and specialised blood collection tubes containing lithium heparin and K2 EDTA) at different temperatures and storage times...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684593/renal-function-n-terminal-pro-b-type-natriuretic-peptide-propeptide-big-endothelin-and-patients-with-heart-failure-and-preserved-ejection-fraction
#4
Ingrid Gergei, Bernhard K Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März
Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684533/lipid-coated-mannitol-core-microparticles-for-sustained-release-of-protein
#5
Bifeng Wang, Wolfgang Friess
Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein stability during manufacturing, storage and application and which are biodegradable and highly biocompatible in the body are intensively sought after. The aim of this study was to generate and study mannitol core microparticles loaded with a monoclonal antibody IgG1 and coated with lipid either hard fat or glyceryl stearate at different coating levels...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684364/inhibition-of-mitochondrial-fission-preserves-photoreceptors-after-retinal-detachment
#6
Xiangjun She, Xinmin Lu, Tong Li, Junran Sun, Jian Liang, Yuanqi Zhai, Shiqi Yang, Qing Gu, Fang Wei, Hong Zhu, Fenghua Wang, Xueting Luo, Xiaodong Sun
Photoreceptor degeneration is a leading cause of visual impairment worldwide. Separation of neurosensory retina from the underlying retinal pigment epithelium is a prominent feature preceding photoreceptor degeneration in a variety of retinal diseases. Although ophthalmic surgeries have been well developed to restore retinal structures, post-op patients usually experience progressive photoreceptor degeneration and irreversible vision loss that is incurable at present. Previous studies point to a critical role of mitochondria-mediated apoptotic pathway in photoreceptor degeneration, but the upstream triggers remain largely unexplored...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684345/transplantation-of-creg-modified-embryonic-stem-cells-improves-cardiac-function-after-myocardial-infarction-in-mice
#7
Jian Zhang, Xiaoxiang Tian, Chengfei Peng, Chenghui Yan, Yang Li, Mingyu Sun, Jian Kang, Erhe Gao, Yaling Han
Engraftment of embryonic stem cells (ESC) has been proposed as a potential therapeutic approach for post-infarction cardiac dysfunction. However, only mild function improvement has been achieved due to low survival rate and paracrine dysfunction of transplanted stem cells. Cellular repressor of E1A stimulated genes (CREG) has been reported to be a secreted glycoprotein implicated in promoting survival and differentiation of many cell types. Therefore we hypothesized that transplantation of genetically modified ESC with CREG (CREG-ESC) can improve cardiac function after myocardial infarction in mice...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684334/the-mkk7-inhibitor-peptide-gadd45%C3%AE-i-attenuates-er-stress-induced-mitochondrial-dysfunction-in-ht22-cells-involvement-of-jnk-wnt-pathway
#8
Guang-Hua Xu, Bing-Jun Song, Dan Liu, Yu-Hua Chen, Yuan Zhou, Wen-Bo Liu, Hua Li, Tian-Lin Long, Rui Zhang, Wei Liu
JNK, a member of the mitogen activated protein kinases (MAPKs) superfamily, plays a key role in cell death in many neurological disorders, but systemic inhibition of JNK has detrimental side effects. JNK can be regulated by two direct upstream kinases: MAPK kinase 4 (MKK4) and MAPK kinase 7 (MKK7). Here, we investigated the effect of GADD45β-I, a recently designed cell-permeable inhibitor peptide for MKK7, on endoplasmic reticulum (ER) stress-induced cytotoxicity in neuronal HT22 cells. We found that treatment with the ER stress inducer tunicamycin (TM) increased the phosphorylation of JNK and MKK7 in HT22 cells, which was nullified by GADD45β-I...
April 20, 2018: Brain Research
https://www.readbyqxmd.com/read/29684325/the-effect-of-isochoric-freezing-on-mammalian-cells-in-an-extracellular-phosphate-buffered-solution
#9
J Preciado, B Rubinsky
Isochoric (constant volume) freezing has been recently suggested as a new method for cell and organ preservation. As a first step in studying the effect of isochoric freezing on mammalian cells, Madin-Darby canine kidney epithelial cells (MDCK), were frozen in an isochoric system, in a simple extracellular phosphate buffered solution to -10 °C (96.5 MPa), - 15 °C (162 MPa) and -20 °C (205 MPa) for 60 and 120 min. Cell membrane integrity and cell metabolism were studied with a Live/Dead cell vitality assay and flow cytometry...
April 20, 2018: Cryobiology
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#10
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#11
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683953/outcomes-of-proton-beam-radiation-therapy-for-retinoblastoma-with-vitreous-seeds
#12
Eun Hye Jung, Jeong Hun Kim, Joo Young Kim, Dong Hyun Jo, Young Suk Yu
Vitreous seeds are the most challenging aspect in the management of retinoblastoma. We report the outcomes of treatment with proton beam radiation therapy (PBRT) for retinoblastoma with vitreous seeds in naive or previously treated eyes. In this retrospective case series, we analyzed data of 4 retinoblastoma patients with vitreous seeds who received PBRT at the Proton Therapy Center, National Cancer Center in Korea between June 2007 and August 2017. All 4 eyes treated by PBRT were classified as group D according to the International Classification of Retinoblastoma (ICRB) criteria, and the vitreous seeds, as class 3 (clouds)...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683801/social-economic-and-policy-implications-of-organ-preservation-advances
#13
Alyssa Ward, David K Klassen, Kate M Franz, Sebastian Giwa, Jedediah K Lewis
PURPOSE OF REVIEW: Despite over 60 years of progress in the field of since the first organ transplant, insufficient organ preservation capabilities still place profound constraints on transplantation. These constraints play multiple and compounding roles in the predominant limitations of the field: the severe shortages of transplant organs, short-term and long-term posttransplant outcomes and complications, the unmet global need for development of transplant infrastructures, and economic burdens that limit patient access to transplantation and contribute to increasing global healthcare costs...
April 21, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29683752/vessel-health-and-preservation-a-model-and-clinical-pathway-for-using-vascular-access-devices
#14
Nancy L Moureau, Peter J Carr
Use of intravenous devices for the delivery of medical treatment spans all healthcare facilities ranging from hospitals to clinics and home care. Clinical pathways are processes used by healthcare providers to integrate and illustrate the best evidence and approach to care for a specific area of practice. The Vessel Health and Preservation (VHP) model is a framework and pathway process, consisting of four quadrants, to guide initiation and management of treatment requiring intravenous access. The pathway is designed to promote preservation of the vasculature of patients from admission through discharge with a focus on acute care...
April 26, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29683498/advanced-platelet-rich-fibrin-and-freeze-dried-bone-allograft-for-ridge-preservation-a-randomized-controlled-clinical-trial
#15
Daniel Clark, Yogalakshmi Rajendran, Sarmad Paydar, Sunita Ho, Darren Cox, Mark Ryder, John Dollard, Richard T Kao
BACKGROUND: Advanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation. METHODS: Forty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29683453/a-blood-based-test-for-the-detection-of-ros1-and-ret-fusion-transcripts-from-circulating-ribonucleic-acid-using-digital-polymerase-chain-reaction
#16
Hestia S Mellert, Kristin E Alexander, Leisa P Jackson, Gary A Pestano
We have developed novel methods for the isolation and characterization of tumor-derived circulating ribonucleic acid (cRNA) for blood-based liquid biopsy. Robust detection of cRNA recovered from blood represents a solution to a critical unmet need in clinical diagnostics. The test begins with the collection of whole blood into blood collection tubes containing preservatives that stabilize cRNA. Cell-free, exosomal, and platelet-associated RNA is isolated from plasma in this test system. The cRNA is reverse transcribed to complementary DNA (cDNA) and amplified using digital polymerase chain reaction (dPCR)...
April 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683437/re-arterialized-rat-partial-liver-transplantation-with-an-in-vivo-vessel-oriented-70-hepatectomy
#17
Xuehai Chen, Rong Yu, Ziqiang Xu, Yan Zhang, Chengyang Liu, Bicheng Chen, Hao Jin
Split liver transplantation and living liver donor liver transplantation were developed in the clinic to utilize liver organs in a more efficient manner. To better understand the mechanism behind these surgical procedures, a rat partial liver transplantation (PLTx) model was established for relevant surgical studies. Because of the complexity of the rat PLTx model, a protocol with detailed descriptions is required. An article published previously reported a protocol in which ex vivo hepatectomy was used to achieve 50% rat PLTx...
April 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683371/hippocampal-related-memory-network-in-multiple-sclerosis-a-structural-connectivity-analysis
#18
Sara Llufriu, Maria A Rocca, Elisabetta Pagani, Gianna C Riccitelli, Elisabeth Solana, Bruno Colombo, Mariaemma Rodegher, Andrea Falini, Giancarlo Comi, Massimo Filippi
BACKGROUND: We used graph theoretical analysis to quantify structural connectivity of the hippocampal-related episodic memory network and its association with memory performance in multiple sclerosis (MS) patients. METHODS: Brain diffusion and T1-weighted sequences were obtained from 71 MS patients and 50 healthy controls (HCs). A total of 30 gray matter regions (selected a priori) were used as seeds to perform probabilistic tractography and create connectivity matrices...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29683324/synthesis-of-semicrystalline-polyolefin-materials-precision-methyl-branching-via-stereoretentive-chain-walking
#19
David N Vaccarello, Kyle S O'Connor, Pasquale Iacono, Jeffrey M Rose, Anna E Cherian, Geoffrey W Coates
We report the discovery of C2 -symmetric nickel catalysts capable of the regio- and isoselective polymerization of 1-butene to produce isotactic 4,2-poly(1-butene), a new semi-crystalline polyolefin. The catalyst exhibits enantioface selectivities as high as 84% and the resulting polymers display melting temperatures up to 86 °C. This system marks a rare example of preserving stereochemistry through a chain walking polymerization process.
April 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29683056/a-geoprivacy-by-design-guideline-for-research-campaigns-that-use-participatory-sensing-data
#20
Ourania Kounadi, Bernd Resch
Participatory sensing applications collect personal data of monitored subjects along with their spatial or spatiotemporal stamps. The attributes of a monitored subject can be private, sensitive, or confidential information. Also, the spatial or spatiotemporal attributes are prone to inferential disclosure of private information. Although there is extensive problem-oriented literature on geoinformation disclosure, our work provides a clear guideline with practical relevance, containing the steps that a research campaign should follow to preserve the participants' privacy...
April 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
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