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https://www.readbyqxmd.com/read/28749268/detection-of-bartonella-sp-in-deer-louse-flies-lipoptena-mazamae-on-gray-brocket-deer-mazama-gouazoubira-in-the-neotropics
#1
Ugo Souza, Bruno Dall'Agnol, Thais Michel, Anelise Webster, Guilherme Klafke, João Ricardo Martins, Carlos Benhur Kasper, Tatiane Campos Trigo, Ricardo Ott, Márcia Maria de Assis Jardim, José Reck
Louse flies or deer keds, Lipoptena spp., are widespread in Neotropical cervids, but the vector-borne pathogens of louse flies had only been previously reported in the Northern hemisphere. This is the first report of Bartonella spp. in deer louse flies (Lipoptena mazamae) in the neotropics collected from gray brocket deer ( Mazama gouazoubira ) in Southern Brazil. DNA from Bartonella sp. was detected in all 429 L. mazamae collected from 11 road-killed gray brocket deer. The same sequences of DNA of Bartonella spp...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28748343/a-phase-i-ii-study-of-gemcitabine-during-radiotherapy-in-children-with-newly-diagnosed-diffuse-intrinsic-pontine-glioma
#2
Sophie E M Veldhuijzen van Zanten, Fatma E El-Khouly, Marc H A Jansen, Dewi P Bakker, Esther Sanchez Aliaga, Cornelis J A Haasbeek, Nicole I Wolf, C Michel Zwaan, W Peter Vandertop, Dannis G van Vuurden, Gertjan J L Kaspers
The purpose of this phase I/II, open-label, single-arm trial is to investigate the safety, tolerability, maximum tolerated dose and preliminary efficacy of the potential radiosensitizer gemcitabine, administered concomitantly to radiotherapy, in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Six doses of weekly gemcitabine were administered intravenously, concomitantly to 6 weeks of hyperfractionated radiotherapy. Successive cohorts received increasing doses of 140, 175 and 200 mg/m(2) gemcitabine, respectively, following a 3 + 3 dose-escalation schedule without expansion cohort...
July 26, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28744105/pattern-of-statin-use-changes-following-media-coverage-of-its-side-effects
#3
Margit Kriegbaum, Kasper Bering Liisberg, Helle Wallach-Kildemoes
BACKGROUND: The media plays a role in shaping opinions about medical decisions, for example, whether to initiate or stop treatment. An association between negative media attention and statin discontinuation has been demonstrated, but it may differ depending on the reason for prescription and whether the user is new (incident) or long term (prevalent). AIM: The aim of this study is to explore whether a Danish newspaper article featuring the side effects of statins affects statin discontinuation in incident versus prevalent users, with the reason for prescription also taken into account...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28739777/establishment-of-a-comprehensive-drug-overdose-fatality-surveillance-system-in-kentucky-to-inform-drug-overdose-prevention-policies-interventions-and-best-practices
#4
Sarah L Hargrove, Terry L Bunn, Svetla Slavova, Dana Quesinberry, Tracey Corey, William Ralston, Michael D Singleton, Van Ingram
BACKGROUND: According to the National Center for Health Statistics, Kentucky had the third highest drug overdose fatality rate in the nation in 2015 at 29.9 drug overdose fatalities per 100 000 population. OBJECTIVE: The elevated drug overdose fatality rate necessitated the development and implementation of a comprehensive multisource drug overdose fatality surveillance system (DOFSS). METHODS: DOFSS stakeholder work group members and data sources were identified, and memorandums of understanding were established...
July 24, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28737166/direct-afm-observation-of-individual-micelles-tile-decorations-and-tiling-rules-of-a-dodecagonal-liquid-quasicrystal
#5
Rui-Bin Zhang, Xiang-Bing Zeng, Goran Ungar
We performed an atomic force microscopy study of the dendron-based dodecagonal quasicrystal, the material that had been reported in 2004 as the first soft quasicrystal. We succeeded in orienting the 12-fold axis perpendicular to the substrate, which allowed imaging of the quasiperiodic xy plane. Thus for the first time we could obtain direct real-space information not only on the arrangement of the tiles, but also on their "decorations" by the individual spherical micelles or "nanoatoms". The high-resolution patterns recorded confirm the square-triangle tiling, but the abundance of the different nodes corresponds closely to random tiling rather than to any inflation rule...
July 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28736280/the-serine-threonine-protein-phosphatase-2a-controls-autoimmunity
#6
Amir Sharabi, Isaac R Kasper, George C Tsokos
Protein phosphatase 2A (PP2A) is the first Ser/Thr phosphatase recognized to contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled both epigenetically and genetically, and it is increased in patients with SLE, which contributes to decreased IL-2 production, decreased CD3ζ and increased FcRγ expression on the surface of T cells, increased CREMα expression, hypomethylation of genes associated with SLE pathogenesis, and increased IL-17 production. B regulatory subunit of PP2A regulates IL-2 deprivation-induced T cell death and is decreased in SLE patients...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28728877/genotype-phenotype-and-disease-severity-reflected-by-serum-lysogb3-levels-in-patients-with-fabry-disease
#7
Albina Nowak, Thomas P Mechtler, Thorsten Hornemann, Joanna Gawinecka, Eva Theswet, Max J Hilz, David C Kasper
BACKGROUND: Fabry disease (FD) is a rare X-linked lysosomal storage disease caused by mutations in the α-galactosidase A (GLA) gene causing deficiency of α-galactosidase A which results in progressive glycosphingolipid accumulation, especially globotriaosylceramide (Gb3), in body liquids and lysosomes. In a large cohort of FD patients, we aimed to establish genotype/phenotype relations as indicated by serum LysoGb3 (deacylated Gb3). METHODS: In 69 consecutive adult FD patients (males: n=28 (41%)) with a GLA-mutation confirmed diagnosis, we conducted a multidisciplinary clinical characterization during their routine annual examinations, and measured serum LysoGb3 levels by high-sensitive electrospray ionization liquid chromatography tandem mass spectrometry...
July 5, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28726960/robust-triplet-triplet-annihilation-photon-upconversion-by-efficient-oxygen-scavenging
#8
Damir Dzebo, Kasper Moth-Poulsen, Bo Albinsson
We hereby present a simple method for reducing the effect of oxygen quenching in Triplet-Triplet Annihilation Upconversion (TTA-UC) systems. A number of commercially available thioethers and one thiol have been tested as singlet oxygen scavengers. Recording of the upconverted emission from a well-studied PdOEP (sensitizer)-DPA (annihilator/emitter) couple has been made over time with steady-state excitation capturing the steady-state kinetics of the TTA-UC process as the solubilized oxygen is depleted by reaction with the scavengers...
July 20, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28724973/alternatives-to-mineral-oil-adjuvants-in-vaccines-against-aeromonas-salmonicida-subsp-salmonicida-in-rainbow-trout-offer-reductions-in-adverse-effects
#9
Kasper Rømer Villumsen, Erling Olaf Koppang, Dennis Christensen, Anders Miki Bojesen
In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection. Using rainbow trout (Oncorhynchus mykiss) as recipients, injection vaccines based on formalin-inactivated Aeromonas salmonicida subspecies salmonicida were formulated with CpG oligodeoxynucleotides, the liposomal cationic adjuvant formulation 01 (CAF01) or with Freund's incomplete adjuvant and administered intraperitoneally...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723843/no-superior-adaptations-to-carbohydrate-periodization-in-elite-endurance-athletes
#10
Kasper Degn Gejl, Line Thams, Mette Hansen, Torben Rokkedal-Lausch, Peter Plomgaard, Lars Nybo, Filip J Larsen, Daniele A Cardinale, Kurt Jensen, Hans-Christer Holmberg, Kristian Vissing, Niels Ørtenblad
PURPOSE: The present study investigated the effects of periodic CHO restriction on endurance performance and metabolic markers in elite endurance athletes. METHODS: Twenty-six male elite endurance athletes (VO2max: 65.0 ml O2[BULLET OPERATOR]kg[BULLET OPERATOR]min) completed 4 weeks of regular endurance training, while matched and randomized into two groups training with (Low) or without (High) carbohydrate (CHO) manipulation three days a week. The CHO manipulation days consisted of a 1-hr high intensity bike session in the morning, recovery for 7 hrs while consuming isocaloric diets containing either high CHO (414±2...
July 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28721647/rubidium-82-pet-imaging-is-feasible-in-a-rat-myocardial-infarction-model
#11
Adam Ali Ghotbi, Andreas Clemmensen, Kasper Kyhl, Bjarke Follin, Philip Hasbak, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjaer
BACKGROUND: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ((82)Rb) in a small-animal scanner using a rat myocardial infarct model. METHODS: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure...
July 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28720809/microbial-turnover-times-in-the-deep-seabed-studied-by-amino-acid-racemization-modelling
#12
Stefan Braun, Snehit S Mhatre, Marion Jaussi, Hans Røy, Kasper U Kjeldsen, Christof Pearce, Marit-Solveig Seidenkrantz, Bo Barker Jørgensen, Bente Aa Lomstein
The study of active microbial populations in deep, energy-limited marine sediments has extended our knowledge of the limits of life on Earth. Typically, microbial activity in the deep biosphere is calculated by transport-reaction modelling of pore water solutes or from experimental measurements involving radiotracers. Here we modelled microbial activity from the degree of D:L-aspartic acid racemization in microbial necromass (remains of dead microbial biomass) in sediments up to ten million years old. This recently developed approach (D:L-amino acid modelling) does not require incubation experiments and is highly sensitive in stable, low-activity environments...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716616/relationship-between-spirituality-meaning-in-life-psychological-distress-wish-for-hastened-death-and-their-influence-on-quality-of-life-in-palliative-care-patients
#13
Mathieu Bernard, Florian Strasser, Claudia Gamondi, Giliane Braunschweig, Michaela Forster, Karin Kaspers-Elekes, Silvia Walther Veri, Gian Domenico Borasio
CONTEXT: Spiritual, existential, and psychological issues represent central components of quality of life (QOL) in palliative care. A better understanding of the dynamic underlying these components is essential for the development of interventions tailored to the palliative context. OBJECTIVES: The aims were to explore (i) the relationship between spirituality, meaning in life, wishes for hastened death and psychological distress in palliative patients, and (ii) the extent to which these non-physical determinants influence QOL...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28714464/dynamic-breaking-of-a-single-gold-bond
#14
Ilya V Pobelov, Kasper Primdal Lauritzen, Koji Yoshida, Anders Jensen, Gábor Mészáros, Karsten W Jacobsen, Mikkel Strange, Thomas Wandlowski, Gemma C Solomon
While one might assume that the force to break a chemical bond gives a measure of the bond strength, this intuition is misleading. If the force is loaded slowly, thermal fluctuations may break the bond before it is maximally stretched, and the breaking force will be less than the bond can sustain. Conversely, if the force is loaded rapidly it is more likely that the maximum breaking force is measured. Paradoxically, no clear differences in breaking force were observed in experiments on gold nanowires, despite being conducted under very different conditions...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28713339/concurrent-methane-production-and-oxidation-in-surface-sediment-from-aarhus-bay-denmark
#15
Ke-Qing Xiao, Felix Beulig, Kasper U Kjeldsen, Bo B Jørgensen, Nils Risgaard-Petersen
Marine surface sediments, which are replete with sulfate, are typically considered to be devoid of endogenous methanogenesis. Yet, methanogenic archaea are present in those sediments, suggesting a potential for methanogenesis. We used an isotope dilution method based on sediment bag incubation and spiking with (13)C-CH4 to quantify CH4 turnover rates in sediment from Aarhus Bay, Denmark. In two independent experiments, highest CH4 production and oxidation rates (>200 pmol cm(-3) d(-1)) were found in the top 0-2 cm, below which rates dropped below 100 pmol cm(-3) d(-1) in all other segments down to 16 cm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28708466/a-bidirectional-association-between-the-gut-microbiota-and-cns-disease-in-a-biphasic-murine-model-of-multiple-sclerosis
#16
Sara L Colpitts, Eli J Kasper, Abigail Keever, Caleb Liljenberg, Trevor Kirby, Krisztian Magori, Lloyd H Kasper, Javier Ochoa-Repáraz
The gut microbiome plays an important role in the development of inflammatory disease as shown using experimental models of central nervous system (CNS) demyelination. Gut microbes influence the response of regulatory immune cell populations in the gut-associated lymphoid tissue (GALT), which drive protection in acute and chronic experimental autoimmune encephalomyelitis (EAE). Recent observations suggest that communication between the host and the gut microbiome is bidirectional. We hypothesized that the gut microbiota differs between the acute inflammatory and chronic progressive stages of a murine model of secondary-progressive multiple sclerosis (SP-MS)...
July 14, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28707751/oral-antifungal-medication-for-toenail-onychomycosis
#17
REVIEW
Sanne Kreijkamp-Kaspers, Kate Hawke, Linda Guo, George Kerin, Sally Em Bell-Syer, Parker Magin, Sophie V Bell-Syer, Mieke L van Driel
BACKGROUND: Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Oral treatments also appear to have shorter treatment times and better cure rates. Our review will assist those needing to make an evidence-based choice for treatment...
July 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28703182/quantum-back-action-evading-measurement-of-motion-in-a-negative-mass-reference-frame
#18
Christoffer B Møller, Rodrigo A Thomas, Georgios Vasilakis, Emil Zeuthen, Yeghishe Tsaturyan, Mikhail Balabas, Kasper Jensen, Albert Schliesser, Klemens Hammerer, Eugene S Polzik
Quantum mechanics dictates that a continuous measurement of the position of an object imposes a random quantum back-action (QBA) perturbation on its momentum. This randomness translates with time into position uncertainty, thus leading to the well known uncertainty on the measurement of motion. As a consequence of this randomness, and in accordance with the Heisenberg uncertainty principle, the QBA puts a limitation-the so-called standard quantum limit-on the precision of sensing of position, velocity and acceleration...
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28701555/consistent-cooperation-in-a-cichlid-fish-is-caused-by-maternal-and-developmental-effects-rather-than-heritable-genetic-variation
#19
Claudia Kasper, Mathias Kölliker, Erik Postma, Barbara Taborsky
Studies on the evolution of cooperative behaviour are typically confined to understanding its adaptive value. It is equally essential, however, to understand its potential to evolve, requiring knowledge about the phenotypic consistency and genetic basis of cooperative behaviour. While previous observational studies reported considerably high heritabilities of helping behaviour in cooperatively breeding vertebrates, experimental studies disentangling the relevant genetic and non-genetic components of cooperative behaviour are lacking...
July 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28701363/infographic-ankle-sprain-treatment-and-prevention-timeline
#20
EDITORIAL
Kasper W Janssen
No abstract text is available yet for this article.
July 12, 2017: British Journal of Sports Medicine
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