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https://www.readbyqxmd.com/read/28088483/physiology-recording-with-magnetic-field-probes-for-fmri-denoising
#1
Simon Gross, Laetitia Vionnet, Lars Kasper, Benjamin E Dietrich, Klaas P Pruessmann
Physiological noise originating in cardiovascular and respiratory processes is a substantial confound in BOLD fMRI. When unaccounted for it reduces the temporal SNR and causes error in inferred brain activity and connectivity. Physiology correction typically relies on auxiliary measurements with peripheral devices such as ECG, pulse oximeters, and breathing belts. These require direct skin contact or at least a tight fit, impairing subject comfort and adding to the setup time. In this work, we explore a touch-free alternative for physiology recording, using magnetic detection with NMR field probes...
January 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28087568/effect-of-specific-exercise-based-football-injury-prevention-programmes-on-the-overall-injury-rate-in-football-a-systematic-review-and-meta-analysis-of-the-fifa-11-and-11-programmes
#2
Kristian Thorborg, Kasper Kühn Krommes, Ernest Esteve, Mikkel Bek Clausen, Else Marie Bartels, Michael Skovdal Rathleff
OBJECTIVE: To investigate the effect of FIFA injury prevention programmes in football (FIFA 11 and FIFA 11+). DESIGN: Systematic review and meta-analysis. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials comparing the FIFA injury prevention programmes with a control (no or sham intervention) among football players. DATA SOURCES: MEDLINE via PubMed, EMBASE via OVID, CINAHL via Ebsco, Web of Science, SportDiscus and Cochrane Central Register of Controlled Trials, from 2004 to 14 March 2016...
January 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28087077/alteration-of-cd39-foxp3-cd4-t-cell-and-cytokine-levels-in-eae-ms-following-anti-cd52-treatment
#3
Anudeep B Pant, Yan Wang, Daniel W Mielcarz, Eli J Kasper, Kiel M Telesford, Megan Mishra, Azizul Haque, Jacqueline Smith, Lloyd H Kasper, Sakhina Begum-Haque
While examining the therapeutic value of anti-CD52 antibody against EAE/MS, we identified a unique subset of CD39+ Tregs in repopulating GALT tissues, a major lymphoid reservoir, which was accompanied by amelioration of disease. Furthermore, anti-CD52 treatment leads to increased expression of BDNF, IL-10, and SMAD3 in the brains of EAE mice. This condition is associated with suppression of IL-17, a critical inflammatory factor in EAE/MS progression. Additionally, we found elevated levels of CD4+CD39+ Tregs in PBMCs of RRMS patients treated with humanized anti-CD52 mAb...
December 21, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28079489/editorial
#4
Siegfried Kasper
No abstract text is available yet for this article.
February 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28077874/asgard-archaea-illuminate-the-origin-of-eukaryotic-cellular-complexity
#5
Katarzyna Zaremba-Niedzwiedzka, Eva F Caceres, Jimmy H Saw, Disa Bäckström, Lina Juzokaite, Emmelien Vancaester, Kiley W Seitz, Karthik Anantharaman, Piotr Starnawski, Kasper U Kjeldsen, Matthew B Stott, Takuro Nunoura, Jillian F Banfield, Andreas Schramm, Brett J Baker, Anja Spang, Thijs J G Ettema
The origin and cellular complexity of eukaryotes represent a major enigma in biology. Current data support scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial) endosymbiont merged together, resulting in the first eukaryotic cell. The host cell is related to Lokiarchaeota, an archaeal phylum with many eukaryotic features. The emergence of the structural complexity that characterizes eukaryotic cells remains unclear. Here we describe the 'Asgard' superphylum, a group of uncultivated archaea that, as well as Lokiarchaeota, includes Thor-, Odin- and Heimdallarchaeota...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28077675/post-hoc-assessment-of-the-immunogenicity-of-bioengineered-factor-viia-demonstrates-the-use-of-preclinical-tools
#6
Kasper Lamberth, Stine Louise Reedtz-Runge, Jonathan Simon, Ksenia Klementyeva, Gouri Shankar Pandey, Søren Berg Padkjær, Véronique Pascal, Ileana R León, Charlotte Nini Gudme, Søren Buus, Zuben E Sauna
Immunogenicity is an important consideration in the licensure of a therapeutic protein because the development of neutralizing anti-drug antibodies (ADAs) can affect both safety and efficacy. Neoantigens introduced by bioengineering of a protein drug are a particular cause for concern. The development of a bioengineered recombinant factor VIIa (rFVIIa) analog was discontinued after phase 3 trials because of the development of ADAs. The unmodified parent molecule (rFVIIa), on the other hand, has been successfully used as a drug for more than two decades with no reports of immunogenicity in congenital hemophilia patients with inhibitors...
January 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28077303/analysis-and-correction-of-field-fluctuations-in-fmri-data-using-field-monitoring
#7
Saskia Bollmann, Lars Kasper, S Johanna Vannesjo, Andreea O Diaconescu, Benjamin E Dietrich, Simon Gross, Klaas E Stephan, Klaas P Pruessmann
This work investigates the role of magnetic field fluctuations as a confound in fMRI. In standard fMRI experiments with single-shot EPI acquisition the uniform and gradient components of the magnetic field were recorded with NMR field sensors. By principal component analysis it is found that differences of field evolution between the EPI readouts are explainable by few components relating to slow and within-shot field dynamics of hardware and physiological origin. The impact of fluctuating field components is studied by selective data correction and assessment of its influence on image fluctuation and SFNR...
January 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28070557/resource-tracking-within-and-across-continents-in-long-distance-bird-migrants
#8
Kasper Thorup, Anders P Tøttrup, Mikkel Willemoes, Raymond H G Klaassen, Roine Strandberg, Marta Lomas Vega, Hari P Dasari, Miguel B Araújo, Martin Wikelski, Carsten Rahbek
Migratory birds track seasonal resources across and between continents. We propose a general strategy of tracking the broad seasonal abundance of resources throughout the annual cycle in the longest-distance migrating land birds as an alternative to tracking a certain climatic niche or shorter-term resource surplus occurring, for example, during spring foliation. Whether and how this is possible for complex annual spatiotemporal schedules is not known. New tracking technology enables unprecedented spatial and temporal mapping of long-distance movement of birds...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28069755/influence-of-the-gut-microbiome-on-autoimmunity-in-the-central-nervous-system
#9
REVIEW
Sara L Colpitts, Lloyd H Kasper
Autoimmune disorders of the CNS have complex pathogeneses that are not well understood. In multiple sclerosis and neuromyelitis optica spectrum disorders, T cells destroy CNS tissue, resulting in severe disabilities. Mounting evidence suggests that reducing inflammation in the CNS may start with modulation of the gut microbiome. The lymphoid tissues of the gut are specialized for the induction of regulatory cells, which are directly responsible for the suppression of CNS-damaging autoreactive T cells. Whether cause or effect, the onset of dysbiosis in the gut of patients with multiple sclerosis and neuromyelitis optica provides evidence of communication along the gut-brain axis...
January 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28069574/left-ventricular-hypertrophy-is-associated-with-increased-infarct-size-and-decreased-myocardial-salvage-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#10
Lars Nepper-Christensen, Jacob Lønborg, Kiril Aleksov Ahtarovski, Dan Eik Høfsten, Kasper Kyhl, Adam Ali Ghotbi, Mikkel Malby Schoos, Christoffer Göransson, Litten Bertelsen, Lars Køber, Steffen Helqvist, Frants Pedersen, Kari Saünamaki, Erik Jørgensen, Henning Kelbæk, Lene Holmvang, Niels Vejlstrup, Thomas Engstrøm
BACKGROUND: Approximately one third of patients with ST-segment elevation myocardial infarction (STEMI) have left ventricular hypertrophy (LVH), which is associated with impaired outcome. However, the causal association between LVH and outcome in STEMI is unknown. We evaluated the association between LVH and: myocardial infarct size, area at risk, myocardial salvage, microvascular obstruction, left ventricular (LV) function (all determined by cardiac magnetic resonance [CMR]), and all-cause mortality and readmission for heart failure in STEMI patients treated with primary percutaneous coronary intervention...
January 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28069072/pansaid-paracetamol-and-nsaid-in-combination-study-protocol-for-a-randomised-trial
#11
Kasper Højgaard Thybo, Daniel Hägi-Pedersen, Jørn Wetterslev, Jørgen Berg Dahl, Henrik Morville Schrøder, Hans Henrik Bülow, Jan Gottfrid Bjørck, Ole Mathiesen
BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. No 'gold standard' exists after total hip arthroplasty (THA) and combinations of different nonopioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy. The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen alone and in combination in different dosages after THA. METHODS: PANSAID is a placebo-controlled, parallel four-group, multicentre trial with centralised computer-generated allocation sequence and allocation concealment and with varying block size and stratification by site...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28068617/what-does-the-madrs-mean-equipercentile-linking-with-the-cgi-using-a-company-database-of-mirtazapine-studies
#12
Stefan Leucht, Hein Fennema, Rolf R Engel, Marion Kaspers-Janssen, Peter Lepping, Armin Szegedi
BACKGROUND: Little is known about the clinical relevance of the Montgomery Asberg Depression Rating Scale (MADRS) total scores. It is unclear how total scores translate into clinical severity, or how commonly used measures for response (reduction from baseline of ≥50% in the total score) translate into clinical relevance. Moreover, MADRS based definitions of remission vary. METHODS: We therefore compared: a/ the MADRS total score with the Clinical Global Impression - Severity Score (CGI-S) b/ the percentage and absolute change in the MADRS total scores with Clinical Global Impression - Improvement (CGI-I); c/ the absolute and percentage change in the MADRS total scores with CGI-S absolute change...
December 29, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28068461/a-new-prediction-model-for-evaluating-treatment-resistant-depression
#13
Alexander Kautzky, Pia Baldinger-Melich, Georg S Kranz, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: Despite a broad arsenal of antidepressants, about a third of patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool of the Group for the Study of Resistant Depression and machine learning, we intended to draw new insights featuring 48 clinical, sociodemographic, and psychosocial predictors for treatment outcome. METHOD: Patients were enrolled starting from January 2000 and diagnosed according to DSM-IV...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28066544/controlling-deposition-of-nanoparticles-by-tuning-surface-charge-of-sio2-by-surface-modifications
#14
Johnas Eklöf, Tina Gschneidtner, Samuel Lara-Avila, Kim Nygård, Kasper Moth-Poulsen
The self-assembly of nanoparticles on substrates is relevant for a variety of applications such as plasmonics, sensing devices and nanometer-sized electronics. We investigate the deposition of 60 nm spherical Au nanoparticles onto silicon dioxide (SiO2) substrates by changing the chemical treatment of the substrate and by that altering the surface charge. The deposition is characterized by scanning electron microscopy (SEM). Kelvin probe force microscopy (KPFM) was used to characterize the surface workfunction...
November 13, 2016: RSC Advances
https://www.readbyqxmd.com/read/28062799/a-two-pronged-binding-mechanism-of-igg-to-the-neonatal-fc-receptor-controls-complex-stability-and-igg-serum-half-life
#15
Pernille Foged Jensen, Angela Schoch, Vincent Larraillet, Maximiliane Hilger, Tilman Schlothauer, Thomas Emrich, Kasper Dyrbert Rand
The success of recombinant monoclonal immunoglobulins (IgG) is rooted in their ability to target distinct antigens with high affinity combined with an extraordinarily long serum half-life, typically around three weeks. The pharmacokinetics of IgGs is intimately linked to the recycling mechanism of the neonatal Fc receptor (FcRn). For long serum half-life of therapeutic IgGs, the highly pH dependent interaction with FcRn needs to be balanced to allow efficient FcRn binding and release at slightly acidic pH and physiological pH, respectively...
January 6, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28062650/euthanasia-embedded-in-palliative-care-responses-to-essentialistic-criticisms-of-the-belgian-model-of-integral-end-of-life-care
#16
Jan L Bernheim, Kasper Raus
The Belgian model of 'integral' end-of-life care consists of universal access to palliative care (PC) and legally regulated euthanasia. As a first worldwide, the Flemish PC organisation has embedded euthanasia in its practice. However, some critics have declared the Belgian-model concepts of 'integral PC' and 'palliative futility' to fundamentally contradict the essence of PC. This article analyses the various essentialistic arguments for the incompatibility of euthanasia and PC. The empirical evidence from the euthanasia-permissive Benelux countries shows that since legalisation, carefulness (of decision making) at the end of life has improved and there have been no significant adverse 'slippery slope' effects...
January 6, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28061834/prevalence-of-airflow-obstruction-in-patients-with-stable-systolic-heart-failure
#17
Morten Dalsgaard, Louis Lind Plesner, Morten Schou, Erik Kjøller, Jørgen Vestbo, Kasper Iversen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an important differential diagnosis in heart failure (HF). However, routine use of spirometry in outpatient HF clinics is not implemented. The aim of the present study was to determine the prevalence of both airflow obstruction and non obstructive lung function impairment in patients with HF and to examine the effect of optimal medical treatment for HF on lung function parameters. METHODS: Consecutive patients with HF (ejection fraction (EF) < 45%) and New York Heart Association (NYHA) functional class II-IV at 10 different outpatient heart failure clinics were examined with spirometry at their first visit and after optimal medical treatment for HF was achieved...
January 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28061374/catecholamines-profiles-at-diagnosis-increased-diagnostic-sensitivity-and-correlation-with-biological-and-clinical-features-in-neuroblastoma-patients
#18
Iedan R N Verly, André B P van Kuilenburg, Nico G G M Abeling, Susan M I Goorden, Marta Fiocco, Frédéric M Vaz, Max M van Noesel, C Michel Zwaan, GertJan L Kaspers, Johannes H M Merks, Huib N Caron, Godelieve A M Tytgat
INTRODUCTION: Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are most commonly analysed in urine of NBL patients. However, their diagnostic sensitivity is suboptimal (82%). Therefore, we performed in-depth analysis of the diagnostic sensitivity of a panel of urinary catecholamine metabolites. PATIENTS AND METHODS: Retrospective study of a panel of 8 urinary catecholamine metabolites (VMA, HVA, 3-methoxytyramine [3MT], dopamine, epinephrine, metanephrine, norepinephrine and normetanephrine [NMN]) from 301 NBL patients at diagnosis...
January 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28060571/m-ficolin-is-present-in-aspergillus-fumigatus-infected-lung-and-modulates-epithelial-cell-immune-responses-elicited-by-fungal-cell-wall-polysaccharides
#19
Kasper Jensen, Kit P Lund, Kimmie B Christensen, Anne T Holm, Lalit Kumar Dubey, Jesper B Moeller, Christine S Jepsen, Anders Schlosser, László Galgóczy, Steffen Thiel, Uffe Holmskov, Grith L Sorensen
Aspergillus fumigatus (A. fumigatus) is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients. Ficolins are secreted pattern recognition molecules of the innate immune system. In the present study, we investigated the unknown role of human M-ficolin in the recognition of, and response to fungal cell wall polysaccharides. M-ficolin was localized to infiltrating granulocytes and monocytes found in the A. fumigatus infected lung. Recombinant M-ficolin (rM-ficolin) bound specifically to A...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28060337/using-rna-sequencing-to-detect-novel-splice-variants-related-to-drug-resistance-in-in-vitro-cancer-models
#20
Rocco Sciarrillo, Anna Wojtuszkiewicz, Irsan E Kooi, Valentina E Gómez, Ugo Boggi, Gerrit Jansen, Gert-Jan Kaspers, Jacqueline Cloos, Elisa Giovannetti
Drug resistance remains a major problem in the treatment of cancer for both hematological malignancies and solid tumors. Intrinsic or acquired resistance can be caused by a range of mechanisms, including increased drug elimination, decreased drug uptake, drug inactivation and alterations of drug targets. Recent data showed that other than by well-known genetic (mutation, amplification) and epigenetic (DNA hypermethylation, histone post-translational modification) modifications, drug resistance mechanisms might also be regulated by splicing aberrations...
December 9, 2016: Journal of Visualized Experiments: JoVE
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