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https://www.readbyqxmd.com/read/28211697/benchmarking-density-functionals-for-chemical-bonds-of-gold
#1
Kasper Planeta Kepp
Gold plays a major role in nanochemistry, catalysis, and electrochemistry. Accordingly, hundreds of studies apply density functionals to study chemical bonding with gold, yet there is no systematic attempt to assess the accuracy of these methods applied to gold. This paper reports a benchmark against 51 experimental bond enthalpies of AuX systems and seven additional polyatomic and cationic molecules. 12 density functionals were tested, covering meta functionals, hybrids with variable HF exchange, double-hybrid, dispersion-corrected and non-hybrid GGA functionals...
February 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28202811/small-birds-big-effects-the-little-auk-alle-alle-transforms-high-arctic-ecosystems
#2
Ivan González-Bergonzoni, Kasper L Johansen, Anders Mosbech, Frank Landkildehus, Erik Jeppesen, Thomas A Davidson
In some arctic areas, marine-derived nutrients (MDN) resulting from fish migrations fuel freshwater and terrestrial ecosystems, increasing primary production and biodiversity. Less is known, however, about the role of seabird-MDN in shaping ecosystems. Here, we examine how the most abundant seabird in the North Atlantic, the little auk (Alle alle), alters freshwater and terrestrial ecosystems around the North Water Polynya (NOW) in Greenland. We compare stable isotope ratios (δ(15)N and δ(13)C) of freshwater and terrestrial biota, terrestrial vegetation indices and physical-chemical properties, productivity and community structure of fresh waters in catchments with and without little auk colonies...
February 22, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28196668/effects-of-sex-hormone-treatment-on-white-matter-microstructure-in-individuals-with-gender-dysphoria
#3
Georg S Kranz, Rene Seiger, Ulrike Kaufmann, Allan Hummer, Andreas Hahn, Sebastian Ganger, Martin Tik, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Sex steroid hormones such as estradiol and testosterone are known to have organizing, as well as activating effects on neural tissue in animals and humans. This study investigated the effects of transgender hormone replacement therapy on white matter microstructure using diffusion tensor imaging. Female-to-male and male-to-female transgender participants were measured at baseline, four weeks and four months past treatment start and compared to female and male controls. We observed androgenization-related reductions in mean diffusivity and increases in fractional anisotropy...
February 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28193854/gene-activation-of-smn-by-selective-disruption-of-lncrna-mediated-recruitment-of-prc2-for-the-treatment-of-spinal-muscular-atrophy
#4
Caroline J Woo, Verena K Maier, Roshni Davey, James Brennan, Guangde Li, John Brothers, Brian Schwartz, Susana Gordo, Anne Kasper, Trevor R Okamoto, Hans E Johansson, Berhan Mandefro, Dhruv Sareen, Peter Bialek, B Nelson Chau, Balkrishen Bhat, David Bullough, James Barsoum
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by progressive motor neuron loss and caused by mutations in SMN1 (Survival Motor Neuron 1). The disease severity inversely correlates with the copy number of SMN2, a duplicated gene that is nearly identical to SMN1. We have delineated a mechanism of transcriptional regulation in the SMN2 locus. A previously uncharacterized long noncoding RNA (lncRNA), SMN-antisense 1 (SMN-AS1), represses SMN2 expression by recruiting the Polycomb Repressive Complex 2 (PRC2) to its locus...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193444/surgical-navigation-a-systematic-review-of-indications-treatments-and-outcomes-in-oral-and-maxillofacial-surgery
#5
REVIEW
Iman Azarmehr, Kasper Stokbro, R Bryan Bell, Torben Thygesen
PURPOSE: This systematic review investigates the most common indications, treatments, and outcomes of surgical navigation (SN) published from 2010 to 2015. The evolution of SN and its application in oral and maxillofacial surgery have rapidly developed over recent years, and therapeutic indications are discussed. MATERIALS AND METHODS: A systematic search in relevant electronic databases, journals, and bibliographies of the included articles was carried out. Clinical studies with 5 or more patients published between 2010 and 2015 were included...
January 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28193043/removal-of-n-linked-glycosylations-at-acidic-ph-by-pngase-a-facilitates-hydrogen-deuterium-exchange-mass-spectrometry-analysis-of-n-linked-glycoproteins
#6
Pernille Foged Jensen, Gerard Comamala, Morten Beck Trelle, Jeppe Buur Madsen, Thomas J D Jørgensen, Kasper D Rand
Protein glycosylation is the most frequent post-translational modification and is present on more than 50% of eukaryotic proteins. Glycosylation covers a wide subset of modifications involving many types of complex oligosaccharide structures, making structural analysis of glycoproteins and their glycans challenging for most analytical techniques. Hydrogen/deuterium exchange monitored by mass spectrometry is a sensitive technique for investigation of protein conformational dynamics of complex heterogeneous proteins in solution...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28185274/clarithromycin-trimethoprim-and-penicillin-and-oxidative-nucleic-acid-modifications-in-humans-randomised-controlled-trials
#7
Emil List Larsen, Vanja Cejvanovic, Laura Kofoed Kjaer, Morten Thorup Pedersen, Sara Daugaard Popik, Lina Kallehave Hansen, Jon Traerup Andersen, Espen Jimenez-Solem, Kasper Broedbaek, Morten Petersen, Allan Weimann, Trine Henriksen, Jens Lykkesfeldt, Christian Torp-Pedersen, Henrik Enghusen Poulsen
AIMS: In vitro studies have demonstrated that formation of reactive oxygen species (ROS) contributes to the effect of bactericidal antibiotics. The formation of ROS is not restricted to bacteria, but also occurs in mammalian cells. Oxidative stress is linked to several diseases. This study investigates whether antibiotic drugs induce oxidative stress in healthy humans as a possible mechanism for adverse reactions to the antibiotic drugs. METHODS: This study contains information from two randomised, controlled trials...
February 10, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28184416/best-practices-for-the-management-of-local-regional-recurrent-chordoma-a-position-paper-by-the-chordoma-global-consensus-group
#8
S Stacchiotti, A Gronchi, P Fossati, T Akiyama, C Alapetite, M Baumann, J Y Blay, S Bolle, S Boriani, P Bruzzi, R Capanna, A Caraceni, R Casadei, V Colia, J Debus, T Delaney, A Desai, P Dileo, S Dijkstra, F Doglietto, A Flanagan, S Froelich, P A Gardner, H Gelderblom, Z L Gokaslan, R Haas, C Heery, N Hindi, P Hohenberger, F Hornicek, R Imai, L Jeys, R L Jones, B Kasper, A Kawai, M Krengli, A Leithner, I Logowska, J Martin Broto, D Mazzatenta, C Morosi, P Nicolai, O J Norum, S Patel, N Penel, P Picci, S Pilotti, S Radaelli, F Ricchini, P Rutkowski, S Scheipl, C Sen, E Tamborini, K A Thornton, B Timmermann, V Torri, P U Tunn, M Uhl, Y Yamada, D C Weber, D Vanel, P P Varga, C LA Vleggeert-Lankamp, P G Casali, J Sommer
No abstract text is available yet for this article.
February 9, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28183219/cilostazol-may-improve-maturation-rates-and-durability-of-vascular-access-for-hemodialysis
#9
Todd E Russell, Gregory C Kasper, Andrew J Seiwert, Anthony J Comerota, Fedor Lurie
Cilostazol is effective in controlling pathophysiological pathways similar or identical to those involved in nonmaturation and failure of the arteriovenous access. This case-control study examined whether cilostazol would improve maturation rates and durability of vascular access for hemodialysis. The treatment group included 33 patients who received cilostazol for ≥30 days prior to creation of a dialysis access and continued with cilostazol therapy for ≥60 days after surgery. The matched (gender, age, race, diabetes, and the year of surgery) control group included 116 patients who underwent the same procedure but did not receive cilostazol prior to and at least 3 months after surgery...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28183217/editorial
#10
Siegfried Kasper
No abstract text is available yet for this article.
March 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28182310/ankyrin-rich-membrane-spanning-protein-as-a-novel-modulator-of-transient-receptor-potential-vanilloid-1-function-in-nociceptive-neurons
#11
J Peter, C Kasper, M Kaufholz, R Buschow, J Isensee, T Hucho, F W Herberg, F Schwede, C Stein, S-E Jordt, M Brackmann, V Spahn
BACKGROUND: The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling events have been intensively investigated, but little is known about the composition of modulating macromolecular TRPV1 signalling complexes. Here, we hypothesize that the novel adaptor protein ankyrin-rich membrane spanning protein/kinase D interacting substrate (ARMS) interacts with TRPV1 and modulates its function in rodent DRG neurons...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28170183/functional-human-and-murine-tissue-engineered-liver-is-generated-from-adult-stem-progenitor-cells
#12
Nirmala Mavila, Andrew Trecartin, Ryan Spurrier, Yi Xiao, Xiaogang Hou, David James, Xiaowei Fu, Brian Truong, Clara Wang, Gerald S Lipshutz, Kasper S Wang, Tracy C Grikscheit
Liver disease affects large numbers of patients, yet there are limited treatments available to replace absent or ineffective cellular function of this crucial organ. Donor scarcity and the necessity for immunosuppression limit one effective therapy, orthotopic liver transplantation. But in some conditions such as inborn errors of metabolism or transient states of liver insufficiency, patients may be salvaged by providing partial quantities of functional liver tissue. After transplanting multicellular liver organoid units composed of a heterogeneous cellular population that includes adult stem and progenitor cells, both mouse and human tissue-engineered liver (TELi) form in vivo...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28158971/single-cell-mrna-isoform-diversity-in-the-mouse-brain
#13
Kasper Karlsson, Sten Linnarsson
BACKGROUND: Alternative mRNA isoform usage is an important source of protein diversity in mammalian cells. This phenomenon has been extensively studied in bulk tissues, however, it remains unclear how this diversity is reflected in single cells. RESULTS: Here we use long-read sequencing technology combined with unique molecular identifiers (UMIs) to reveal patterns of alternative full-length isoform expression in single cells from the mouse brain. We found a surprising amount of isoform diversity, even after applying a conservative definition of what constitutes an isoform...
February 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28158895/mimicking-exercise-in-three-dimensional-bioengineered-skeletal-muscle-to-investigate-cellular-and-molecular-mechanisms-of-physiological-adaptation
#14
REVIEW
Andreas M Kasper, Daniel C Turner, Neil R W Martin, Adam P Sharples
Bioengineering of skeletal muscle in-vitro in order to produce highly aligned myofibres in relevant three dimensional (3D) matrices have allowed scientists to model the in-vivo skeletal muscle niche. This review discusses essential experimental considerations for developing bioengineered muscle in order to investigate exercise mimicking stimuli. We identify current knowledge in the use of electrical stimulation and co-culture with motor neurons to enhance skeletal muscle maturation and contractile function in bioengineered systems in-vitro...
February 3, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28158724/the-marine-sulfate-reducer-desulfobacterium-autotrophicum-hrm2-can-switch-between-low-and-high-apparent-half-saturation-constants-for-dissimilatory-sulfate-reduction
#15
Irene Harder Tarpgaard, Bo Barker Jørgensen, Kasper Urup Kjeldsen, Hans Røy
No abstract text is available yet for this article.
February 2, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28158269/predictors-of-opioid-efficacy-in-patients-with-chronic-pain-a-prospective-multicenter-observational-cohort-study
#16
Kasper Grosen, Anne E Olesen, Mikkel Gram, Torsten Jonsson, Michael Kamp-Jensen, Trine Andresen, Christian Nielsen, Gorazd Pozlep, Mogens Pfeiffer-Jensen, Bart Morlion, Asbjørn M Drewes
Opioids are increasingly used for treatment of chronic pain. However, they are only effective in a subset of patients and have multiple side effects. Thus, studies using biomarkers for response are highly warranted. The current study prospectively examined 63 opioid-naïve patients initiating opioid use for diverse types of chronic pain at five European centers. Quantitative sensory testing, electroencephalography (EEG) recordings, and assessment of pain catastrophizing were performed prior to treatment. The co-primary outcomes were change from baseline in ratings of chronic pain and quality of life after 14 days of opioid treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28145877/transcatheter-mitral-paravalvular-leak-closure-facilitated-by-preprocedural-cardiac-ct-for-simulation-of-fluoroscopic-anatomy-and-paravalvular-defect-localization
#17
Kasper Korsholm, Ulrik Mortensen, Jesper Møller Jensen, Nicolo Piazza, Pascal Thériault-Lauzier, Jens Erik Nielsen-Kudsk
Paravalvular leakage (PVL) occurs in 6%-15% of cases after surgical heart valve replacement. A percutaneous approach is increasingly used to close PVLs as an alternative to repeat surgery. Computed tomography (CT) can be used for simulation of fluoroscopic cardiac anatomy. This technique allows preprocedural definition of optimal C-arm angulations and PVL localization in reference to fluoroscopic views. It is very helpful for guidewire crossing of the PVL and positioning of the closure device. We report a case with the first use of dedicated software for fluoroscopic simulation (FluoroCT) in transcatheter mitral PVL closure...
February 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28145450/development-of-a-human-vasopressin-v1a-receptor-antagonist-from-an-evolutionary-related-insect-neuropeptide
#18
Maria Giulia Di Giglio, Markus Muttenthaler, Kasper Harpsøe, Zita Liutkeviciute, Peter Keov, Thomas Eder, Thomas Rattei, Sarah Arrowsmith, Susan Wray, Ales Marek, Tomas Elbert, Paul F Alewood, David E Gloriam, Christian W Gruber
Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and cloned its cognate receptor and determined its pharmacological properties on the insect and human oxytocin/vasopressin receptors...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144773/lumbar-disk-herniation-during-pregnancy-a-review-on-general-management-and-timing-of-surgery
#19
REVIEW
Hugo Ardaillon, Yosef Laviv, Jeffrey E Arle, Ekkehard M Kasper
STUDY DESIGN: Narrative review with case illustration. OBJECTIVE: Provide an overview of existing management strategies to suggest a guideline for surgical management of lumbar disk herniation in pregnant women based on time of presentation. METHODS: We performed a narrative review on the topic using the PubMed database. A total of 63 relevant articles published after 1992 were identified, of which 17 fulfilled selection criteria. RESULTS: A total of 22 published cases of spine surgery for disk herniation during pregnancy were found in 17 studies on the topic...
January 31, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28143718/comparative-efficacy-of-bilateral-thoracoscopic-splanchnicectomy-for-intractable-pain-secondary-to-pancreatic-cancer-vs-chronic-pancreatitis
#20
Neal Bhutiani, Gerald A Cheadle, Michael H Bahr, Gary C Vitale
BACKGROUND: Splanchnicectomy has been evaluated for treatment of chronic pain in both pancreatic cancer and chronic pancreatitis patients, though its efficacy has not been compared in these two patient populations. This study aims to compare bilateral thoracoscopic splanchnicectomy (BTS) in treatment of abdominal pain secondary to pancreatic cancer (PC) and chronic pancreatitis (CP). METHODS: A University of Louisville database was evaluated from July 1998 to March 2016 for patients undergoing BTS for intractable pain secondary to PC (n=48) or CP (n=75)...
January 28, 2017: Journal of the American College of Surgeons
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