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https://www.readbyqxmd.com/read/29776961/mr-proadm-as-a-prognostic-marker-in-patients-with-st-segment-elevation-myocardial-infarction-danami-3-a-danish-study-of-optimal-acute-treatment-of-patients-with-stemi-substudy
#1
Alexander C Falkentoft, Rasmus Rørth, Kasper Iversen, Dan E Høfsten, Henning Kelbæk, Lene Holmvang, Martin Frydland, Mikkel M Schoos, Steffen Helqvist, Anna Axelsson, Peter Clemmensen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Frants Pedersen, Christian Torp-Pedersen, Klaus F Kofoed, Jens P Goetze, Thomas Engstrøm, Lars Køber
BACKGROUND: Midregional proadrenomedullin (MR-proADM) has demonstrated prognostic potential after myocardial infarction (MI). Yet, the prognostic value of MR-proADM at admission has not been examined in patients with ST-segment-elevation MI (STEMI). METHODS AND RESULTS: The aim of this substudy, DANAMI-3 (The Danish Study of Optimal Acute Treatment of Patients with ST-segment-elevation myocardial infarction), was to examine the associations of admission concentrations of MR-proADM with short- and long-term mortality and hospital admission for heart failure in patients with ST-segment-elevation myocardial infarction...
May 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29775085/usage-of-therapeutic-sleep-deprivation-a-survey-in-psychiatric-hospitals-in-austria-germany-and-switzerland
#2
Dietmar Winkler, Marie Spies, Yasmin Al-Resheg, Joseph C Wu, William E Bunney, Blynn G Bunney, Siegfried Kasper, Edda Pjrek
OBJECTIVE: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is used most often for depression. The aim of this study was to examine the pattern of use of SD in psychiatric hospitals in Austria, Germany, and Switzerland. METHODS: A questionnaire about perceived usage of SD was sent by mail to all 511 psychiatric hospitals in the three countries. Nonresponders were asked to answer the questionnaire by phone. We achieved a response rate of 75...
May 18, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29773602/clofarabine-high-dose-cytarabine-and-liposomal-daunorubicin-in-pediatric-relapsed-refractory-acute-myeloid-leukemia-a-phase-ib-study
#3
Natasha K A van Eijkelenburg, Mareike Rasche, Essam Ghazaly, Michael N Dworzak, Thomas Klingebiel, Claudia Rossig, Guy Leverger, Jan Stary, Eveline S J M de Bont, Dana A Chitu, Yves Bertrand, Benoit Brethon, Brigitte Strahm, Inge M van der Sluis, Gertjan J L Kaspers, Dirk Reinhardt, C Michel Zwaan
Survival in children with relapsed/refractory acute myeloid leukemia is unsatisfactory. Treatment consists of one course fludarabine, cytarabine and liposomal daunorubicin, followed by fludarabine and cytarabine and stem-cell transplantation. Study ITCC 020/I-BFM 2009-02 aimed to identify the recommended phase 2 dose of clofarabine replacing fludarabine in the abovementioned combination regimen (3+3 design). Escalating dose-levels of clofarabine (20-40mg/m2/day x5days) and liposomal daunorubicin (40-0mg/m2/day) were administered with cytarabine (2g/m2/day x5days)...
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29773181/mercury-and-selenium-in-fishes-from-the-tapaj%C3%A3-s-river-in-the-brazilian-amazon-an-evaluation-of-human-exposure
#4
A S Lino, D Kasper, Y S Guida, J R Thomaz, O Malm
This work aimed to evaluate associated risks of fish consumption to human health, concerning mercury (Hg) and selenium (Se) concentrations in fish species largely consumed in the Tapajós River basin in the Brazilian Amazon. Total mercury (THg), methylmercury (MeHg) and Se concentrations were measured in 129 fish specimens from four sites of the Tapajós River basin. Estimated daily intake (EDI) of Hg and Se were reported regarding fish consumption. EDI were compared with the reference value of provisional tolerable daily intake proposed by the World Health Organization (WHO)...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29769524/molecular-solar-thermal-energy-storage-in-photoswitch-oligomers-increases-energy-densities-and-storage-times
#5
Mads Mansø, Anne Ugleholdt Petersen, Zhihang Wang, Paul Erhart, Mogens Brøndsted Nielsen, Kasper Moth-Poulsen
Molecular photoswitches can be used for solar thermal energy storage by photoisomerization into high-energy, meta-stable isomers; we present a molecular design strategy leading to photoswitches with high energy densities and long storage times. High measured energy densities of up to 559 kJ kg-1 (155 Wh kg-1 ), long storage lifetimes up to 48.5 days, and high quantum yields of conversion of up to 94% per subunit are demonstrated in norbornadiene/quadricyclane (NBD/QC) photo-/thermoswitch couples incorporated into dimeric and trimeric structures...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29769284/dynamic-copy-number-evolution-of-x-and-y-linked-ampliconic-genes-in-human-populations
#6
Elise A Lucotte, Laurits Skov, Jacob Malte Jensen, Moisès Coll Macià, Kasper Munch, Mikkel H Schierup
Ampliconic genes are multicopy, in majority found on sex-chromosomes and enriched for testis-expressed genes. While ampliconic genes have been associated with the emergence of hybrid incompatibilities, we know little about their copy number distribution and their turnover in human populations. Here we explore the evolution of human X- and Y-linked ampliconic genes by investigating copy number variation (CNV) and coding variation between populations using the Simons Genome Diversity Project. We develop a method to assess CNVs using the read-depth on modified X and Y chromosome targets containing only one repetition of each ampliconic gene...
May 16, 2018: Genetics
https://www.readbyqxmd.com/read/29765253/use-of-histamine-h-2-receptor-antagonists-and-outcomes-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#7
Kasper Adelborg, Jens Sundbøll, Morten Schmidt, Hans Erik Bøtker, Noel S Weiss, Lars Pedersen, Henrik Toft Sørensen
Background: Histamine H2 receptor activation promotes cardiac fibrosis and apoptosis in mice. However, the potential effectiveness of histamine H2 receptor antagonists (H2RAs) in humans with heart failure is largely unknown. We examined the association between H2RA initiation and all-cause mortality among patients with heart failure. Methods: Using Danish medical registries, we conducted a nationwide population-based active-comparator cohort study of new users of H2RAs and proton pump inhibitors (PPIs) after first-time hospitalization for heart failure during the period 1995-2014...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29764259/personalised-and-precision-psychiatry-what-do-the-cinp-bipolar-guidelines-suggest
#8
Konstantinos N Fountoulakis, Hans Jurgen Moeller, Siegfried Kasper
No abstract text is available yet for this article.
May 15, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29758051/the-effect-of-acylation-with-fatty-acids-and-other-modifications-on-hla-class-ii-peptide-binding-and-t-cell-stimulation-for-three-model-peptides
#9
Heidi S Schultz, Søren Østergaard, John Sidney, Kasper Lamberth, Alessandro Sette
Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications, like acylation with fatty acids. However, acylation with fatty acids has been shown in some cases to modulate T cell activation. Therefore, to understand the role of acylation with fatty acids on immunogenicity we tested three immunogenic non-acylated peptides and 14 of their acylated analogues for binding to 26 common HLA class II alleles, and their ability to activate T cells in an ex vivo T cell assay...
2018: PloS One
https://www.readbyqxmd.com/read/29756037/substrate-modulated-unwinding-of-transmembrane-helices-in-the-nss-transporter-leut
#10
Patrick S Merkle, Kamil Gotfryd, Michel A Cuendet, Katrine Z Leth-Espensen, Ulrik Gether, Claus J Loland, Kasper D Rand
LeuT, a prokaryotic member of the neurotransmitter:sodium symporter (NSS) family, is an established structural model for mammalian NSS counterparts. We investigate the substrate translocation mechanism of LeuT by measuring the solution-phase structural dynamics of the transporter in distinct functional states by hydrogen/deuterium exchange mass spectrometry (HDX-MS). Our HDX-MS data pinpoint LeuT segments involved in substrate transport and reveal for the first time a comprehensive and detailed view of the dynamics associated with transition of the transporter between outward- and inward-facing configurations in a Na+ - and K+ -dependent manner...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29755375/influence-of-crhr1-polymorphisms-and-childhood-abuse-on-suicide-attempts-in-affective-disorders-a-gxe-approach
#11
Birgit Ludwig, Klemens Kienesberger, Laura Carlberg, Patrick Swoboda, Alexandra Bernegger, Romina Koller, Qingzhong Wang, Michelle Inaner, Melanie Zotter, Nestor D Kapusta, Helmuth Haslacher, Martin Aigner, Siegfried Kasper, Alexandra Schosser
Background: Previous studies have shown that the hypothalamus-pituitary-adrenal-axis (HPA-axis) is closely involved in the development of affective disorders. Given that early life events are also linked to dysregulation of the same system, there might be an association between childhood adversities and suicidal behavior in affective disorders, moderated by HPA-axis genes. We aimed to investigate a potential association between childhood trauma and previous suicide attempts in affective disorder patients, moderated by variants of the corticotropin-releasing hormone receptor 1 (CRHR1) gene...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29753788/installation-validation-and-application-examples-of-two-instrumental-setups-for-gas-phase-hdx-ms-analysis-of-peptides-and-proteins
#12
Ulrik H Mistarz, Kasper D Rand
Gas-phase hydrogen/deuterium exchange measured by mass spectrometry in a millisecond timeframe after ESI (gas-phase HDX-MS) is a fast and sensitive, yet unharnessed method to analyze the primary- and higher-order structure, intramolecular and intermolecular interactions, surface properties, and charge location of peptides and proteins. During a gas-phase HDX-MS experiment, heteroatom-bound non-amide hydrogens are made to exchange with deuterium during a millisecond timespan after electrospray ionization (ESI) by reaction with the highly basic reagent ND3 , enabling conformational analysis of protein states that are pertinent to the native solution-phase...
May 10, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29748208/relationship-between-cough-associated-changes-in-csf-flow-and-disease-severity-in-chiari-i-malformation-an-exploratory-study-using-real-time-mri
#13
A F Bezuidenhout, D Khatami, C B Heilman, E M Kasper, S Patz, N Madan, Y Zhao, R A Bhadelia
BACKGROUND AND PURPOSE: Currently no quantitative objective test exists to determine disease severity in a patient with Chiari I malformation. Our aim was to correlate disease severity in symptomatic patients with Chiari I malformation with cough-associated changes in CSF flow as measured with real-time MR imaging. MATERIALS AND METHODS: Thirteen symptomatic patients with Chiari I malformation (tonsillar herniation of ≥5 mm) were prospectively studied. A real-time, flow-sensitized pencil-beam MR imaging scan was used to measure CSF stroke volume during rest and immediately following coughing and relaxation periods (total scan time, 90 seconds)...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29746225/clinical-radiologic-pathologic-and-molecular-characteristics-of-long-term-survivors-of-diffuse-intrinsic-pontine-glioma-dipg-a-collaborative-report-from-the-international-and-european-society-for-pediatric-oncology-dipg-registries
#14
Lindsey M Hoffman, Sophie E M Veldhuijzen van Zanten, Niclas Colditz, Joshua Baugh, Brooklyn Chaney, Marion Hoffmann, Adam Lane, Christine Fuller, Lili Miles, Cynthia Hawkins, Ute Bartels, Eric Bouffet, Stewart Goldman, Sarah Leary, Nicholas K Foreman, Roger Packer, Katherine E Warren, Alberto Broniscer, Mark W Kieran, Jane Minturn, Melanie Comito, Emmett Broxson, Chie-Schin Shih, Soumen Khatua, Murali Chintagumpala, Anne Sophie Carret, Nancy Yanez Escorza, Timothy Hassall, David S Ziegler, Nicholas Gottardo, Hetal Dholaria, Renee Doughman, Martin Benesch, Rachid Drissi, Javad Nazarian, Nada Jabado, Nathalie Boddaert, Pascale Varlet, Géraldine Giraud, David Castel, Stephanie Puget, Chris Jones, Esther Hulleman, Piergiorgio Modena, Marzia Giagnacovo, Manila Antonelli, Torsten Pietsch, Gerrit H Gielen, David T W Jones, Dominik Sturm, Stefan M Pfister, Nicolas U Gerber, Michael A Grotzer, Elke Pfaff, André O von Bueren, Darren Hargrave, Guirish A Solanki, Filip Jadrijevic Cvrlje, Gertjan J L Kaspers, William P Vandertop, Jacques Grill, Simon Bailey, Veronica Biassoni, Maura Massimino, Raphaël Calmon, Esther Sanchez, Brigitte Bison, Monika Warmuth-Metz, James Leach, Blaise Jones, Dannis G van Vuurden, Christof M Kramm, Maryam Fouladi
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, the United Kingdom, and Croatia...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29744486/thermodynamically-accessible-titanium-clusters-ti-n-n-2-32
#15
Tomas Lazauskas, Alexey A Sokol, John Buckeridge, C Richard A Catlow, Susanne G E T Escher, Matthew R Farrow, David Mora-Fonz, Volker W Blum, Tshegofatso M Phaahla, Hasani R Chauke, Phuti E Ngoepe, Scott M Woodley
We have performed a genetic algorithm search on the tight-binding interatomic potential energy surface (PES) for small TiN (N = 2-32) clusters. The low energy candidate clusters were further refined using density functional theory (DFT) calculations with the PBEsol exchange-correlation functional and evaluated with the PBEsol0 hybrid functional. The resulting clusters were analysed in terms of their structural features, growth mechanism and surface area. The results suggest a growth mechanism that is based on forming coordination centres by interpenetrating icosahedra, icositetrahedra and Frank-Kasper polyhedra...
May 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29743675/137-ancient-human-genomes-from-across-the-eurasian-steppes
#16
Peter de Barros Damgaard, Nina Marchi, Simon Rasmussen, Michaël Peyrot, Gabriel Renaud, Thorfinn Korneliussen, J Víctor Moreno-Mayar, Mikkel Winther Pedersen, Amy Goldberg, Emma Usmanova, Nurbol Baimukhanov, Valeriy Loman, Lotte Hedeager, Anders Gorm Pedersen, Kasper Nielsen, Gennady Afanasiev, Kunbolot Akmatov, Almaz Aldashev, Ashyk Alpaslan, Gabit Baimbetov, Vladimir I Bazaliiskii, Arman Beisenov, Bazartseren Boldbaatar, Bazartseren Boldgiv, Choduraa Dorzhu, Sturla Ellingvag, Diimaajav Erdenebaatar, Rana Dajani, Evgeniy Dmitriev, Valeriy Evdokimov, Karin M Frei, Andrey Gromov, Alexander Goryachev, Hakon Hakonarson, Tatyana Hegay, Zaruhi Khachatryan, Ruslan Khaskhanov, Egor Kitov, Alina Kolbina, Tabaldiev Kubatbek, Alexey Kukushkin, Igor Kukushkin, Nina Lau, Ashot Margaryan, Inga Merkyte, Ilya V Mertz, Viktor K Mertz, Enkhbayar Mijiddorj, Vyacheslav Moiyesev, Gulmira Mukhtarova, Bekmukhanbet Nurmukhanbetov, Z Orozbekova, Irina Panyushkina, Karol Pieta, Václav Smrčka, Irina Shevnina, Andrey Logvin, Karl-Göran Sjögren, Tereza Štolcová, Kadicha Tashbaeva, Alexander Tkachev, Turaly Tulegenov, Dmitriy Voyakin, Levon Yepiskoposyan, Sainbileg Undrakhbold, Victor Varfolomeev, Andrzej Weber, Nikolay Kradin, Morten E Allentoft, Ludovic Orlando, Rasmus Nielsen, Martin Sikora, Evelyne Heyer, Kristian Kristiansen, Eske Willerslev
For thousands of years the Eurasian steppes have been a centre of human migrations and cultural change. Here we sequence the genomes of 137 ancient humans (about 1× average coverage), covering a period of 4,000 years, to understand the population history of the Eurasian steppes after the Bronze Age migrations. We find that the genetics of the Scythian groups that dominated the Eurasian steppes throughout the Iron Age were highly structured, with diverse origins comprising Late Bronze Age herders, European farmers and southern Siberian hunter-gatherers...
May 9, 2018: Nature
https://www.readbyqxmd.com/read/29741573/proteomevis-a-web-app-for-exploration-of-protein-properties-from-structure-to-sequence-evolution-across-organisms-proteomes
#17
Rostam M Razban, Amy I Gilson, Niamh Durfee, Hendrik Strobelt, Kasper Dinkla, Jeong-Mo Choi, Hanspeter Pfister, Eugene I Shakhnovich
Motivation: Protein evolution spans time scales and its effects span the length of an organism. A web app named ProteomeVis is developed to provide a comprehensive view of protein evolution in the S. cerevisiae and E. coli proteomes. ProteomeVis interactively creates protein chain graphs, where edges between nodes represent structure and sequence similarities within user-defined ranges, to study the long time scale effects of protein structure evolution. The short time scale effects of protein sequence evolution are studied by sequence evolutionary rate (ER) correlation analyses with protein properties that span from the molecular to the organismal level...
May 8, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29741267/health-care-providers-perspectives-on-health-insurance-access-waiving-procedures-and-hospital-detention-practices-in-kenya
#18
Saskia Mostert, Festus Njuguna, Renske H M van der Burgt, Joyce Musimbi, Sandra Langat, Jodi Skiles, Anneloes Seijffert, Mei N Sitaresmi, Terry A Vik, Peter M van de Ven, Gertjan J L Kaspers
BACKGROUND: Patients at Kenyan public hospitals are detained if their families cannot pay their medical bills. Access to health insurance and waiving procedures to prevent detention may be limited. This study explores the perspectives of health-care providers (HCP) on health-insurance access, waiving procedures, and hospital detention practices. PROCEDURE: A self-administered structured questionnaire was completed by 104 HCP (response rate 78%) involved in childhood cancer care...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29740834/multidisciplinary-care-considerations-for-gender-nonconforming-adolescents-with-eating-disorders-a-case-series
#19
Abigail A Donaldson, Allison Hall, Jodie Neukirch, Vania Kasper, Shannon Simones, Sherry Gagnon, Steven Reich, Michelle Forcier
Gender nonconforming youth are at risk for body dissatisfaction and disordered eating. Currently, only a small body of literature addresses this high-risk group. The five cases in this series highlight important themes for this patient population from an interdisciplinary perspective. Identified themes include increased risk for self-harm/suicide, complex psychiatric, and medical implications of delay to treatment for either gender dysphoria or disordered eating, and the importance of collaborative management to maximize care and facilitate healthy development to adulthood...
May 8, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29740506/carotid-artery-stenting-vs-carotid-endarterectomy-in-the-management-of-carotid-artery-stenosis-lessons-learned-from-randomized-controlled-trials
#20
REVIEW
Mohamed M Salem, Abdulrahman Y Alturki, Matthew R Fusco, Ajith J Thomas, Bob S Carter, Clark C Chen, Ekkehard M Kasper
Background: Carotid artery stenosis, both symptomatic and asymptomatic, has been well studied with several multicenter randomized trials. The superiority of carotid endarterectomy (CEA) to medical therapy alone in both symptomatic and asymptomatic carotid artery stenosis has been well established in previous trials in the 1990s. The consequent era of endovascular carotid artery stenting (CAS) has offered another option for treating carotid artery stenosis. A series of randomized trials have now been conducted to compare CEA and CAS in the treatment of carotid artery disease...
2018: Surgical Neurology International
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