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https://www.readbyqxmd.com/read/28431609/benefit-risk-perception-of-natalizumab-therapy-in-neurologists-and-a-large-cohort-of-multiple-sclerosis-patients
#1
Christoph Heesen, Ingo Kleiter, Sven G Meuth, Julia Krämer, Jürgen Kasper, Sascha Köpke, Wolfgang Gaissmaier
BACKGROUND: Natalizumab (NAT) is associated with the risk of progressive multifocal leukoencephalopathy (PML). Risk stratification algorithms have been developed, however, without detectable reduction of PML incidence. OBJECTIVE: To evaluate to which extent patients and physicians understand and accept risks associated with NAT treatment. METHODS: Prospective observational cohort study in German MS centers (n=73) among NAT-treated MS patients (n=801) and their neurologists (n=99)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28430133/nuclear-molecular-imaging-strategies-in-immune-checkpoint-inhibitor-therapy
#2
REVIEW
Kasper F Guldbrandsen, Helle W Hendel, Seppo W Langer, Barbara M Fischer
Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as immune related side effects and immune cell infiltration may be confused with progressive disease. Furthermore, the timing of the evaluation scan may be challenged by relatively slow responses...
April 21, 2017: Diagnostics
https://www.readbyqxmd.com/read/28427345/variation-in-gp-decisions-on-antihypertensive-treatment-in-oldest-old-and-frail-individuals-across-29-countries
#3
Sven Streit, Marjolein Verschoor, Nicolas Rodondi, Daiana Bonfim, Robert A Burman, Claire Collins, Gerasimovska Kitanovska Biljana, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisoneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Tuz Canan, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Jacobijn Gussekloo, Rosalinde K E Poortvliet
BACKGROUND: In oldest-old patients (>80), few trials showed efficacy of treating hypertension and they included mostly the healthiest elderly. The resulting lack of knowledge has led to inconsistent guidelines, mainly based on systolic blood pressure (SBP), cardiovascular disease (CVD) but not on frailty despite the high prevalence in oldest-old. This may lead to variation how General Practitioners (GPs) treat hypertension. Our aim was to investigate treatment variation of GPs in oldest-olds across countries and to identify the role of frailty in that decision...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28420967/organization-and-plasticity-of-sodium-channel-expression-in-the-mouse-olfactory-and-vomeronasal-epithelia
#4
Florian Bolz, Stephanie Kasper, Bernd Bufe, Frank Zufall, Martina Pyrski
To understand the molecular basis of neuronal excitation in the mammalian olfactory system, we conducted a systematic analysis of the organization of voltage-gated sodium (Nav) channel subunits in the main olfactory epithelium (MOE) and vomeronasal organ (VNO) of adult mice. We also analyzed changes in Nav channel expression during development in these two systems and during regeneration of the MOE. Quantitative PCR shows that Nav1.7 is the predominant isoform in both adult MOE and VNO. We detected pronounced immunoreactivity for Nav1...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28411600/cc2-oscillator-strengths-within-the-local-framework-for-calculating-excitation-energies-lofex
#5
Pablo Baudin, Thomas Kjærgaard, Kasper Kristensen
In a recent work [P. Baudin and K. Kristensen, J. Chem. Phys. 144, 224106 (2016)], we introduced a local framework for calculating excitation energies (LoFEx), based on second-order approximated coupled cluster (CC2) linear-response theory. LoFEx is a black-box method in which a reduced excitation orbital space (XOS) is optimized to provide coupled cluster (CC) excitation energies at a reduced computational cost. In this article, we present an extension of the LoFEx algorithm to the calculation of CC2 oscillator strengths...
April 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28411221/an-extracellular-cell-attached-pullulanase-confers-branched-%C3%AE-glucan-utilization-in-human-gut-lactobacillus-acidophilus
#6
Marie S Møller, Yong Jun Goh, Kasper Bøwig Rasmussen, Wojciech Cypryk, Hasan Ufuk Celebioglu, Todd R Klaenhammer, Birte Svensson, Maher Abou Hachem
Of the few predicted extracellular glycan-active enzymes, glycoside hydrolase family 13 subfamily 14 (GH13_14) pullulanases are the most common in human gut lactobacilli. These enzymes share a unique modular organization, not observed in other bacteria, featuring a catalytic module, two starch binding modules, a domain of unknown function, and a C-terminal surface layer association protein (SLAP) domain. Here we explore the specificity of a representative of this group of pullulanases, LaPul13_14 and its role in branched α-glucans metabolism in the well characterized Lactobacillus acidophilus NCFM that is widely used as a probiotic...
April 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28408968/effect-of-ring-strain-on-the-charge-transport-of-a-robust-norbornadiene-quadricyclane-based-molecular-photoswitch
#7
Behabitu E Tebikachew, Haipeng B Li, Alessandro Pirrotta, Karl Börjesson, Gemma C Solomon, Joshua Hihath, Kasper Moth-Poulsen
Integrating functional molecules into single-molecule devices is a key step toward the realization of future computing machines based on the smallest possible components. In this context, photoswitching molecules that can make a transition between high and low conductivity in response to light are attractive candidates. Here we present the synthesis and conductance properties of a new type of robust molecular photothermal switch based on the norbornadiene (NB)-quadricyclane (QC) system. The transport through the molecule in the ON state is dominated by a pathway through the π-conjugated system, which is no longer available when the system is switched to the OFF state...
April 6, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28408101/a-new-technique-for-accelerated-liver-regeneration-an-experimental-study-in-rats
#8
Kasper Jarlhelt Andersen, Anders Riegels Knudsen, Betina Norman Jepsen, Michelle Meier, Anders Patrik Alexander Gunnarsson, Uffe Birk Jensen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit, Frank Viborg Mortensen
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is used to accelerate growth of the future liver remnant. We investigated alternative methods for increasing the future liver remnant. METHODS: A total of 152 rats were randomized as follows: (1) sham; (2) portal vein ligation; (3) portal vein ligation/surgical split (ALPPS); (4) portal vein ligation/split of the liver with a radiofrequency ablation needle; (5) portal vein ligation/radiofrequency ablation of the deportalized liver (portal vein ligation/radiofrequency ablation necrosis in the deportalized liver); (6) portal vein ligation/radiofrequency ablation of the future liver remnant (portal vein ligation/radiofrequency ablation-future liver remnant); and (7) controls...
April 10, 2017: Surgery
https://www.readbyqxmd.com/read/28407601/changes-in-household-food-insecurity-are-related-to-changes-in-bmi-and-diet-quality-among-michigan-head-start-preschoolers-in-a-sex-specific-manner
#9
Erica C Jansen, Nicole Kasper, Julie C Lumeng, Holly E Brophy Herb, Mildred A Horodynski, Alison L Miller, Dawn Contreras, Karen E Peterson
Children living in households that have recently become food insecure may be particularly vulnerable to adverse weight and dietary changes, but longitudinal studies examining these associations are lacking. Using data from 501 Head Start preschoolers from Michigan (48% male) who were followed during one school year as a part of a randomized obesity prevention trial, we examined changes in children's adiposity indices and dietary quality according to changes in household food insecurity. Household food insecurity change status was categorized as persistently food secure, became food secure, persistently food insecure, or became food insecure...
April 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28407432/diagnosis-of-biofilm-infections-in-cystic-fibrosis-patients
#10
REVIEW
Niels Høiby, Thomas Bjarnsholt, Claus Moser, Peter Østrup Jensen, Mette Kolpen, Tavs Qvist, Kasper Aanaes, Tanja Pressler, Marianne Skov, Oana Ciofu
Chronic Pseudomonas aeruginosa biofilm lung infection in cystic fibrosis patients is the best described biofilm infection in medicine. The initial focus can be the paranasal sinuses and then follows repeated colonization and infection of the lungs by aspiration. The matrix of the biofilms is dominated by alginate and the pathogenesis of tissue damage is immune complex-mediated chronic inflammation dominated by polymorphonuclear leukocytes and their products (DNA, oxygen radicals and proteases). The P. aeruginosa biofilm infection can be diagnosed by microscopy of lung tissue, sputum and mucus from the paranasal sinuses, where aggregates of the bacteria are found surrounded by the abundant alginate matrix...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28407427/microenvironmental-characteristics-and-physiology-of-biofilms-in-chronic-infections-of-cf-patients-are-strongly-affected-by-the-host-immune-response
#11
REVIEW
Peter Ø Jensen, Mette Kolpen, Kasper N Kragh, Michael Kühl
In vitro studies of Pseudomonas aeruginosa and other pathogenic bacteria in biofilm aggregates have yielded detailed insight into their potential growth modes and metabolic flexibility under exposure to gradients of substrate and electron acceptor. However, the growth pattern of P. aeruginosa in chronic lung infections of cystic fibrosis (CF) patients is very different from what is observed in vitro, for example, in biofilms grown in flow chambers. Dense in vitro biofilms of P. aeruginosa exhibit rapid O2 depletion within <50-100 μm due to their own aerobic metabolism...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28402383/loss-channels-in-triplet-triplet-annihilation-photon-upconversion-importance-of-annihilator-singlet-and-triplet-surface-shapes
#12
Victor Gray, Ambra Dreos, Paul Erhart, Bo Albinsson, Kasper Moth-Poulsen, Maria Abrahamsson
Triplet-triplet annihilation photon upconversion (TTA-UC) can, through a number of energy transfer processes, efficiently combine two low frequency photons into one photon of higher frequency. TTA-UC systems consist of one absorbing species (the sensitizer) and one emitting species (the annihilator). Herein, we show that the structurally similar annihilators, 9,10-diphenylanthracene (DPA, 1), 9-(4-phenylethynyl)-10-phenylanthracene (2) and 9,10-bis(phenylethynyl)anthracene (BPEA, 3) have very different upconversion efficiencies, 15...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28401576/a-new-nomenclature-for-classifying-psychotropic-drugs
#13
Filippo Caraci, S J Enna, Joseph Zohar, Giorgio Racagni, Gil Zalsman, Wim van den Brink, Siegfried Kasper, George F Koob, Carmine M Pariante, Pier Vincenzo Piazza, Kiyofumi Yamada, Michael Spedding, Filippo Drago
The Neuroscience-based Nomenclature (NbN) for psychotropic drugs was developed as an alternative to the current Anatomical Therapeutic Chemical (ATC) indication-based classification in order to provide more precise designations for this drug class. The ATC nomenclature for psychotherapeutics is limited in that it fails to specify neither pharmacological domains nor mechanism of action and also does not describe all the potential uses of a particular agent. The disconnect between the drug classification and its clinical use is not very useful for scientific purposes and is confusing for patients and caregivers, often leading to a misunderstanding of the intended effects of the prescribed medication and, most importantly, to low treatment adherence...
April 12, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28400749/radiative-energy-budgets-of-phototrophic-surface-associated-microbial-communities-and-their-photosynthetic-efficiency-under-diffuse-and-collimated-light
#14
Mads Lichtenberg, Kasper E Brodersen, Michael Kühl
We investigated the radiative energy budgets of a heterogeneous photosynthetic coral reef sediment and a compact uniform cyanobacterial biofilm on top of coastal sediment. By combining electrochemical, thermocouple and fiber-optic microsensor measurements of O2, temperature and light, we could calculate the proportion of the absorbed light energy that was either dissipated as heat or conserved by photosynthesis. We show, across a range of different incident light regimes, that such radiative energy budgets are highly dominated by heat dissipation constituting up to 99...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28398307/reproducible-rna-seq-analysis-using-recount2
#15
Leonardo Collado-Torres, Abhinav Nellore, Kai Kammers, Shannon E Ellis, Margaret A Taub, Kasper D Hansen, Andrew E Jaffe, Ben Langmead, Jeffrey T Leek
No abstract text is available yet for this article.
April 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28398101/robot-assisted-pyeloplasty-and-pyelolithotomy-in-patients-with-ureteropelvic-junction-stenosis
#16
Pernille Hammershøj Jensen, Kasper Drimer Berg, Nessn H Azawi
OBJECTIVE: Approximately one in five patients with ureteropelvic junction stenosis (UPJS) also present with renal or ureteral stones. For patients with UPJS, the European Association of Urology guidelines currently recommend that robot-assisted pyeloplasty (RAP) and pyelolithotomy are performed as two separate procedures. The aim of the present study was to evaluate the feasibility and safety of RAP with concomitant pyelolithotomy (RAP + P) in patients diagnosed with UPJS and renal stones...
April 11, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28396494/lipocalin-2-from-both-myeloid-cells-and-epithelium-combats-klebsiella-pneumoniae-lung-infection-in-mice
#17
Elisabeth P Cramer, Sara L Dahl, Björn Rozell, Kasper Jermiin Knudsen, Kim Thomsen, Claus Moser, Jack B Cowland, Niels Borregaard
No abstract text is available yet for this article.
April 10, 2017: Blood
https://www.readbyqxmd.com/read/28393357/inflammatory-biomarkers-and-cancer-crp-and-supar-as-markers-of-incident-cancer-in-patients-with-serious-non-specific-symptoms-and-signs-of-cancer
#18
Line Jee Hartmann Rasmussen, Martin Schultz, Anne Gaardsting, Steen Ladelund, Peter Garred, Kasper Iversen, Jesper Eugen-Olsen, Morten Helms, Kim Peter David, Andreas Kjaer, Anne-Mette Lebech, Gitte Kronborg
In Denmark, patients with serious non-specific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2, and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC...
April 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28392715/positive-predictive-values-of-international-classification-of-diseases-10th-revision-codes-for-dermatologic-events-and-hypersensitivity-leading-to-hospitalization-or-emergency-room-visit-among-women-with-postmenopausal-osteoporosis-in-the-danish-and-swedish
#19
Kasper Adelborg, Lotte Brix Christensen, Troels Munch, Johnny Kahlert, Ylva Trolle Lagerros, Grethe S Tell, Ellen M Apalset, Fei Xue, Vera Ehrenstein
BACKGROUND: Clinical epidemiology research studies, including pharmacoepidemiology and pharmacovigilance studies, use routinely collected health data, such as diagnoses recorded in national health and administrative registries, to assess clinical effectiveness and safety of treatments. We estimated positive predictive values (PPVs) of International Classification of Diseases, 10th revision (ICD-10) codes for primary diagnoses of dermatologic events and hypersensitivity recorded at hospitalization or emergency room visit in the national patient registries of Denmark and Sweden among women with postmenopausal osteoporosis (PMO)...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28391217/effects-of-preview-on-human-control-behavior-in-tracking-tasks-with-various-controlled-elements
#20
Kasper van der El, Daan M Pool, Marinus M van Paassen, Max Mulder
This paper investigates how humans use a previewed target trajectory for control in tracking tasks with various controlled element dynamics. The human's hypothesized "near" and "far" control mechanisms are first analyzed offline in simulations with a quasi-linear model. Second, human control behavior is quantified by fitting the same model to measurements from a human-in-the-loop experiment, where subjects tracked identical target trajectories with a pursuit and a preview display, each with gain, single-, and double-integrator controlled element dynamics...
April 4, 2017: IEEE Transactions on Cybernetics
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