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https://www.readbyqxmd.com/read/28544945/longitudinal-association-between-diabetes-and-cognitive-decline-the-national-health-and-aging-trends-study
#1
Alexandra M V Wennberg, Clinton E Hagen, Rebecca F Gottesman, Vadim Zipunnikov, Christopher N Kaufmann, Marilyn S Albert, George W Rebok, Judith D Kasper, Adam P Spira
Type II diabetes mellitus (DM) is associated with increased risk of dementia; however, few studies have examined the longitudinal association between DM and cognitive outcomes in large nationally representative cohorts. We investigated these associations in 7605 participants enrolled in the National Health and Aging Trends Study, a nationally representative prospective study of Medicare beneficiaries ≥65, from 2011 to 2015. Participants or proxy respondents reported DM and dementia diagnosis, and participants completed immediate and delayed recall word list learning tests and the Clock Drawing Test...
May 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28544489/thromboembolic-and-bleeding-complications-during-oral-anticoagulation-therapy-in-cancer-patients-with-atrial-fibrillation-a-danish-nationwide-population-based-cohort-study
#2
Anne G Ording, Erzsébet Horváth-Puhó, Kasper Adelborg, Lars Pedersen, Paolo Prandoni, Henrik T Sørensen
Coexisting cancer in patients with atrial fibrillation (AF) has been associated with thromboembolism and bleeding. We used Danish population-based medical databases to conduct a population-based cohort study that included all AF patients who redeemed a prescription for vitamin K antagonists (VKA) or non-VKA oral anticoagulant (NOAC) between July 2004 and December 2013. We characterized these patients according to the presence (N = 11,855) or absence (N = 56,264) of a cancer diagnosis before redemption of their oral anticoagulant prescription, and then examined their 1-year risk of thromboembolic or bleeding complications or death...
May 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28540121/comprehensive-preoperative-staging-system-for-endoscopic-single-and-multicorridor-approaches-to-juvenile-nasal-angiofibromas
#3
Trichy N Janakiram, Shilpee B Sharma, Ekkehard Kasper, Onkar Deshmukh, Iype Cherian
BACKGROUND: Juvenile nasal angiofibromas (JNA) is a benign lesion with high vascularity and propensity of bone erosion leading to skull base invasion and intracranial extension. It is known to involve multiple compartments, which are often surgically difficult to access. With evolution in surgical expertise and technical innovations, endoscopic and endoscopic-assisted management has become the preferred choice of surgical management. Over the last four decades, various staging systems have been proposed, which are largely based on the extent of nasal angiofibroma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28537270/coherent-structural-trapping-through-wave-packet-dispersion-during-photoinduced-spin-state-switching
#4
Henrik T Lemke, Kasper S Kjær, Robert Hartsock, Tim B van Driel, Matthieu Chollet, James M Glownia, Sanghoon Song, Diling Zhu, Elisabetta Pace, Samir F Matar, Martin M Nielsen, Maurizio Benfatto, Kelly J Gaffney, Eric Collet, Marco Cammarata
The description of ultrafast nonadiabatic chemical dynamics during molecular photo-transformations remains challenging because electronic and nuclear configurations impact each other and cannot be treated independently. Here we gain experimental insights, beyond the Born-Oppenheimer approximation, into the light-induced spin-state trapping dynamics of the prototypical [Fe(bpy)3](2+) compound by time-resolved X-ray absorption spectroscopy at sub-30-femtosecond resolution and high signal-to-noise ratio. The electronic decay from the initial optically excited electronic state towards the high spin state is distinguished from the structural trapping dynamics, which launches a coherent oscillating wave packet (265 fs period), clearly identified as molecular breathing...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28536583/sediment-resuspension-and-deposition-on-seagrass-leaves-impedes-internal-plant-aeration-and-promotes-phytotoxic-h2s-intrusion
#5
Kasper E Brodersen, Kathrine J Hammer, Verena Schrameyer, Anja Floytrup, Michael A Rasheed, Peter J Ralph, Michael Kühl, Ole Pedersen
HIGHLIGHTS: Sedimentation of fine sediment particles onto seagrass leaves severely hampers the plants' performance in both light and darkness, due to inadequate internal plant aeration and intrusion of phytotoxic H2S. Anthropogenic activities leading to sediment re-suspension can have adverse effects on adjacent seagrass meadows, owing to reduced light availability and the settling of suspended particles onto seagrass leaves potentially impeding gas exchange with the surrounding water. We used microsensors to determine O2 fluxes and diffusive boundary layer (DBL) thickness on leaves of the seagrass Zostera muelleri with and without fine sediment particles, and combined these laboratory measurements with in situ microsensor measurements of tissue O2 and H2S concentrations...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28529540/the-potential-role-of-infectious-agents-and-pelvic-inflammatory-disease-in-ovarian-carcinogenesis
#6
REVIEW
Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall, Jan Blaakaer
BACKGROUND: The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM: To review the literature on studies examining the association between ovarian cancer and bacterial or viral infection or pelvic inflammatory disease. METHODS: Database search through MEDLINE, applying the medical subject headings: "Ovarian neoplasms", AND "Chlamydia infections", "Neisseria gonorrhoeae", "Mycoplasma genitalium", "Papillomaviridae", or "pelvic inflammatory disease"...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28522099/psychometric-properties-and-dutch-norm-values-of-the-children-s-sleep-habits-questionnaire-in-toddlers
#7
Lindsay Martina Helena Steur, Eva Henriëtte Visser, Martha Alexandra Grootenhuis, Caroline Barbara Terwee, Gerardus Johannes Laurentius Kaspers, Raphaële Reine Lydie van Litsenburg
OBJECTIVE: The Children's Sleep Habits Questionnaire (CSHQ) was developed in the USA for children aged 4-10 years. The Dutch CSHQ has been validated for this age group, but not yet for toddlers. Furthermore, Dutch norm values for toddlers are unavailable. This study aimed to investigate the psychometric properties and collect norm values of the Dutch CSHQ in toddlers. METHODS: Data collection was conducted by Taylor Nelson Sofres Netherlands Institute for Public Opinion (TNS-NIPO), a Dutch market research agency...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521608/editorial
#8
Siegfried Kasper
No abstract text is available yet for this article.
June 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28521082/training-doctors-briefly-and-in-situ-to-involve-their-patients-in-making-medical-decisions-preliminary-testing-of-a-newly-developed-module
#9
Jürgen Kasper, Katrin Liethmann, Christoph Heesen, Daniel R Reissmann, Friedemann Geiger
OBJECTIVE: To carry out preliminary evaluation of a training module for doctors to enhance their ability to involve their patients in medical decision making. The training refers to the shared decision-making (SDM) communication concept. METHODS: The training module includes a comprehensive manual, a corresponding video tutorial with communication examples and a 15-minute face-to-face feedback session based on an SDM analysis of a consultation recording provided by the trainee...
May 18, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28520578/robust-antidepressant-effect-following-alternating-intravenous-racemic-ketamine-and-electroconvulsive-therapy-in-treatment-resistant-depression-a-case-report
#10
Lucie Bartova, Ana Weidenauer, Markus Dold, Angela Naderi-Heiden, Siegfried Kasper, Matthaeus Willeit, Nicole Praschak-Rieder
No abstract text is available yet for this article.
May 18, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28516933/experimental-characterization-of-a-quantum-many-body-system-via-higher-order-correlations
#11
Thomas Schweigler, Valentin Kasper, Sebastian Erne, Igor Mazets, Bernhard Rauer, Federica Cataldini, Tim Langen, Thomas Gasenzer, Jürgen Berges, Jörg Schmiedmayer
Quantum systems can be characterized by their correlations. Higher-order (larger than second order) correlations, and the ways in which they can be decomposed into correlations of lower order, provide important information about the system, its structure, its interactions and its complexity. The measurement of such correlation functions is therefore an essential tool for reading, verifying and characterizing quantum simulations. Although higher-order correlation functions are frequently used in theoretical calculations, so far mainly correlations up to second order have been studied experimentally...
May 17, 2017: Nature
https://www.readbyqxmd.com/read/28514721/impact-of-gh-administration-on-athletic-performance-in-healthy-young-adults-a-systematic-review-and-meta-analysis-of-placebo-controlled-trials
#12
REVIEW
Kasper Hermansen, Mads Bengtsen, Michael Kjær, Peter Vestergaard, Jens Otto Lunde Jørgensen
OBJECTIVE: Illicit use of growth hormone (GH) as a performance-enhancing drug among athletes is prevalent, although the evidence of such effects in healthy, young subjects is sparse. We therefore performed a meta-analysis of published studies on the effect of GH administration on body composition, substrate metabolism, and athletic performance in healthy, young subjects. DESIGN: The English-language based databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched, and eligible articles were reviewed in accordance with the PRISMA guidelines...
May 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28514141/subtype-specific-agonists-for-nmda-receptor-glycine-binding-sites
#13
Alex Maolanon, Rune Risgaard, Shuang-Yan Wang, Yoran Snoep, Athanasios Papangelis, Feng Yi, David Holley, Anne F Barslund, Niels Svenstrup, Kasper B Hansen, Rasmus Prætorius Clausen
A series of analogues based on serine as lead structure were designed and their agonist activities were evaluated at recombinant NMDA receptor subtypes (GluN1/2A-D) using two-electrode voltage-clamp (TEVC) electrophysiology. Pronounced variation in subunit-selectivity, potency, and agonist efficacy was observed in a manner that was dependent on the GluN2 subunit in the NMDA receptor. In particular, compounds 15a and 16a are potent GluN2C-specific superagonists at the GluN1 subunit with agonist efficacies of 398% and 308% compared to glycine...
May 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#14
S Kasper, W E Müller, H P Volz, H J Möller, E Koch, A Dienel
OBJECTIVE: Silexan is a lavender oil preparation available in capsules containing 80 mg. Here we review clinical trials investigating its anxiolytic efficacy, safety, and tolerability in humans as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
May 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28509663/editorial-issue-2-2017international-journal-of-psychiatry-in-clinical-practice
#15
Siegfried Kasper
No abstract text is available yet for this article.
June 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28507280/molecular-dissection-of-effector-mechanisms-of-ras-mediated-resistance-to-anti-egfr-antibody-therapy
#16
Stefan Kasper, Henning Reis, Sophie Ziegler, Silke Nothdurft, Andre Mueller, Moritz Goetz, Marcel Wiesweg, Jeannette Phasue, Saskia Ting, Sarah Wieczorek, Anna Even, Karl Worm, Michael Pogorzelski, Sandra Breitenbuecher, Johannes Meiler, Andreas Paul, Tanja Trarbach, Kurt Werner Schmid, Frank Breitenbuecher, Martin Schuler
Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), cetuximab and panitumumab, are a mainstay of metastatic colorectal cancer (mCRC) treatment. However, a significant number of patients suffer from primary or acquired resistance. RAS mutations are negative predictors of clinical efficacy of anti-EGFR antibodies in patients with mCRC. Oncogenic RAS activates the MAPK and PI3K/AKT pathways, which are considered the main effectors of resistance. However, the relative impact of these pathways in RAS-mutant CRC is less defined...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28507110/controlled-release-of-plectasin-nz2114-from-a-hybrid-silicone-hydrogel-material-for-inhibition-of-staphylococcus-aureus-biofilm
#17
Kasper Klein, Rasmus Birkholm Grønnemose, Martin Alm, Karoline Sidelmann Brinch, Hans Jørn Kolmos, Thomas Emil Andersen
Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here we evaluated the potential for combining this system with plectasin derivate NZ2114, in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising anti-biofilm properties, also against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28505673/-hla-b27-positive-acute-anterior-uveitis-a-translational-perspective
#18
Arnd Heiligenhaus, Maren Kasper, Rafael Grajewski
Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro- and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28501776/inhibition-of-senp3-by-urb597-ameliorates-neurovascular-unit-dysfunction-in-rats-with-chronic-cerebral-hypoperfusion
#19
Da-Peng Wang, Ke-Jia Liu, Graham Kasper, Qi Lin, Jian Hai
Disruption of the neurovascular unit (NVU), induced by chronic cerebral hypoperfusion (CCH), has been broadly found in various neurological disorders. SUMO-specific protease 3 (SENP3) is expressed in neurons, astrocytes, and microglia, and regulates a variety of cell events. However, whether SENP3 is involved in neurovascular injury under the condition of CCH is still elusive. To address this issue, we investigated the effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597 on NVU and the role of SENP3 in this process, as well as the underling mechanisms...
May 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28501130/collateral-artery-pathways-of-the-femoral-and-popliteal-artery
#20
Rombout R Kruse, Denise E Doomernik, Kasper V Maltha, Jan G M Kooloos, Tamas L Kozicz, Michel M P J Reijnen
BACKGROUND: The role of collateral artery circulation in the lower limb is under debate but clinically relevant, particularly when using covered stents for occlusive disease. Covered stents seem to outperform nitinol stents in extensive disease, but collaterals could be essential in case of acute thrombosis. In the present study, we describe the collateral pathways of the deep and superficial femoral artery (DFA, SFA) and the popliteal artery (PA), observed in human cadavers. METHODS: Ten fresh frozen cadaver legs were selected...
May 1, 2017: Journal of Surgical Research
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