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https://www.readbyqxmd.com/read/29145565/outcome-prediction-in-patients-with-localized-soft-tissue-sarcoma-which-tool-is-the-best
#1
B Kasper, E Wardelmann
No abstract text is available yet for this article.
November 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29142101/loss-of-adam9-expression-impairs-%C3%AE-1-integrin-endocytosis-focal-adhesion-formation-and-cancer-cell-migration
#2
Kasper J Mygind, Jeanette Schwarz, Pranshu Sahgal, Johanna Ivaska, Marie Kveiborg
The transmembrane protease ADAM9 is frequently upregulated in human cancers and it promotes tumour progression in mice. In vitro, ADAM9 regulates cancer cell adhesion and migration by interacting with integrins. Yet, how ADAM9 modulates integrin functions is not known. We here show that ADAM9 knockdown increases β1 integrin levels through mechanisms independent of its protease activity. In ADAM9-silenced cells, adhesion to collagen and fibronectin is reduced, suggesting an altered function of the accumulated integrins...
November 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29141808/what-should-a-person-with-relapsing-remitting-multiple-sclerosis-know-focus-group-and-survey-data-of-a-risk-knowledge-questionnaire-rikno-2-0
#3
C Heesen, J Pöttgen, A C Rahn, K Liethmann, J Kasper, L Vahter, J Drulovic, A Van Nunen, D Wilkie, Y Beckmann, F Paul, S Köpke, A Giordano, A Solari
BACKGROUND: Risk knowledge is relevant to make informed decisions in multiple sclerosis (MS). The risk knowledge questionnaire for relapsing-remitting MS (RIKNO 1.0) was developed and piloted in Germany. OBJECTIVE: To produce a revised RIKNO 2.0 questionnaire using mixed methodology in a European setting. METHODS: The questionnaire was translated in seven languages. MS patient and health professional (HP) expert feedback was obtained from Germany, Italy, Estonia, Serbia, and the UK...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141257/phalloplasty-in-female-to-male-transsexuals-by-gottlieb-and-levine-s-free-radial-forearm-flap-technique-a-long-term-single-center-experience-over-more-than-two-decades
#4
Anna E Wirthmann, Pawel Majenka, Melanie C Kaufmann, Sascha V Wellenbrock, Lara Kasper, Susanne Hüttinger, Gabriel Djedovic, Ahmet Bozkurt, Michael Sohn, Ulrich M Rieger
No abstract text is available yet for this article.
November 15, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29137278/comprehensive-microrna-sequencing-of-exosomes-derived-from-head-and-neck-carcinoma-cells-in-vitro-reveals-common-secretion-profiles-and-potential-utility-as-salivary-biomarkers
#5
Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic, Susan Kasper
Exosomes are nano-scale, membrane encapsulated vesicles that are released by cells into the extracellular space and function as intercellular signaling vectors through horizontal transfer of biologic molecules, including microRNA (miRNA). There is evidence that cancer-derived exosomes enable the tumor to manipulate its microenvironment, thus contributing to the capacity of the tumor for immune evasion, growth, invasion, and metastatic spread. The objective of this study was to characterize differential secretion of exosomal miRNA by head and neck squamous cell carcinoma (HNSCC) and identify a set of candidate biomarkers that could be detected in non-invasive saliva samples...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134288/task-relevant-brain-networks-identified-with-simultaneous-pet-mr-imaging-of-metabolism-and-connectivity
#6
Andreas Hahn, Gregor Gryglewski, Lukas Nics, Lucas Rischka, Sebastian Ganger, Helen Sigurdardottir, Chrysoula Vraka, Leo Silberbauer, Thomas Vanicek, Alexander Kautzky, Wolfgang Wadsak, Markus Mitterhauser, Markus Hartenbach, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger
Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively...
November 13, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29126999/on-the-use-of-liposome-controls-in-studies-investigating-the-clinical-potential-of-extracellular-vesicle-based-drug-delivery-systems-a-commentary
#7
REVIEW
Kasper Bendix Johnsen, Johann Mar Gudbergsson, Meg Duroux, Torben Moos, Thomas Lars Andresen, Jens Bæk Simonsen
The field of extracellular vesicle (EV)-based drug delivery systems has evolved significantly through the recent years, and numerous studies suggest that these endogenous nanoparticles can function as efficient drug delivery vehicles in a variety of diseases. Many characteristics of these EV-based drug delivery vehicles suggest them to be superior at residing in the systemic circulation and possibly at mediating therapeutic effects compared to synthetic drug delivery vehicles, e.g. liposomes. In this Commentary, we discuss how some currently published head-to-head comparisons of EVs versus liposomes are weakened by the inadequate choice of liposomal formulation, and encourage researchers to implement better controls to show any potential superiority of EVs over other synthetic nanoparticles...
November 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29122361/ventilation-measured-on-clinical-4d-cbct-increased-ventilation-accuracy-through-improved-image-quality
#8
Kasper R Jensen, Carsten Brink, Olfred Hansen, Uffe Bernchou
BACKGROUND AND PURPOSE: Ventilation measured on 4D cone-beam computed tomography (CBCT) using deformable image registration (DIR) may predict specific radiation sensitivity, but the measurement is affected by the current image quality. With 4D computed tomography (CT) measured ventilation acting as a gold standard the current study investigates if image improvements increase the accuracy of 4D-CBCT measured ventilation. MATERIAL AND METHODS: The study consists of 4D-CBCT and 4D-CT scans of 20 non-small-cell lung cancer patients...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29117645/proteomic-profiling-of-tgfbi-null-mouse-corneas-reveals-only-minor-changes-in-matrix-composition-supportive-of-tgfbi-knockdown-as-therapy-against-tgfbi-linked-corneal-dystrophies
#9
Ebbe Toftgaard Poulsen, Kasper Runager, Nadia Sukusu Nielsen, Marie V Lukassen, Karen Thomsen, Paige Snider, Olga Simmons, Henrik Vorum, Simon J Conway, Jan J Enghild
TGFBIp is a constituent of the extracellular matrix in many human tissues including the cornea, where it is one of the most abundant proteins expressed. TGFBIp interacts with Type I, II, IV, VI and XII collagens as well as several members of the integrin family, suggesting it plays an important role in maintaining structural integrity and possibly corneal transparency as well. Significantly, more than 60 point mutations within the TGFBI gene have been reported to result in aberrant TGFBIp folding and aggregation in the cornea, resulting in severe visual impairment and blindness...
November 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29117261/diagnostic-accuracy-of-the-roche-septifast-pcr-system-for-the-rapid-detection-of-blood-pathogens-in-neonatal-sepsis-a-prospective-clinical-trial
#10
Julia Straub, Helga Paula, Michaela Mayr, David Kasper, Ojan Assadian, Angelika Berger, Judith Rittenschober-Böhm
INTRODUCTION: Diagnosis of neonatal sepsis remains a major challenge in neonatology. Most molecular-based methods are not customized for neonatal requirements. The aim of the present study was to assess the diagnostic accuracy of a modified multiplex PCR protocol for the detection of neonatal sepsis using small blood volumes. METHODS: 212 episodes of suspected neonatal late onset sepsis were analyzed prospectively using the Roche SeptiFast® MGRADE PCR with a modified DNA extraction protocol and software-handling tool...
2017: PloS One
https://www.readbyqxmd.com/read/29116479/contrasting-grammatical-and-lexical-determiners
#11
Violaine Michel Lange, Maria Messerschmidt, Kasper Boye
This paper investigates the difference between the production of grammatical determiners and lexical determiners in the production of adjective-noun phrases (NPs) in Danish. Models of sentence processing (Garrett in Psychology of learning and motivation, Academic press, New York, pp 133-177, 1975; Bock in J Mem Lang 26(2):119-137, 1987) suggest that the phonological encoding stage of grammatical items can only be specified once lexical items have been phonologically encoded. In their usage-based linguistic theory of the grammar-lexicon distinction, Boye and Harder (Lang 88(1):1-44, 2012) propose that this later encoding of grammatical elements is motivated by two specific features of grammatical elements...
November 7, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29116032/single-cell-transcriptomics-suggest-that-human-adipocyte-progenitor-cells-constitute-a-homogeneous-cell-population
#12
Juan R Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén, Jurga Laurencikiene
Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASCs with different differentiation properties. In addition, ASCs are becoming the biggest source of mesenchymal stem cells used in therapies, which requires deep characterization. Using unbiased single cell transcriptomics we aimed to characterize ASC populations in human subcutaneous white adipose tissue (scWAT)...
November 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29115708/cyp3a5-genotype-and-its-impact-on-vincristine-pharmacokinetics-and-development-of-neuropathy-in-kenyan-children-with-cancer
#13
Jodi L Skiles, ChienWei Chiang, Claire H Li, Steve Martin, Ellen L Smith, Gilbert Olbara, David R Jones, Terry A Vik, Saskia Mostert, Floor Abbink, Gertjan J Kaspers, Lang Li, Festus Njuguna, Tammy J Sajdyk, Jamie L Renbarger
BACKGROUND: Vincristine (VCR) is a critical part of treatment in pediatric malignancies and is associated with dose-dependent peripheral neuropathy (vincristine-induced peripheral neuropathy [VIPN]). Our previous findings show VCR metabolism is regulated by the CYP3A5 gene. Individuals who are low CYP3A5 expressers metabolize VCR slower and experience more severe VIPN as compared to high expressers. Preliminary observations suggest that Caucasians experience more severe VIPN as compared to nonCaucasians...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115099/spinal-meningiomas-61-cases-with-predictors-of-early-postoperative-surgical-outcomes
#14
Ahmed B Bayoumi, Yosef Laviv, Ceren N Karaali, Kemal Ertilav, Umit Kepoglu, Zafer O Toktas, Deniz Konya, Ekkehard M Kasper
BACKGROUND: Spinal meningiomas are benign, well-circumscribed and slowly growing intradural tumors that compress the spinal cord. Hereby, a retrospective review of 61 spinal meningioma cases evaluated in terms of demographic, clinical, pathological and radiological features to predict the early postoperative functional outcomes. METHODS: Patients' records and MRI images of all the histologically confirmed spinal meningioma cases that underwent surgical resection at two university hospitals from January 2005 to June 2016 were retrospectively reviewed...
November 7, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29114301/subependymal-giant-cell-astrocytoma-associated-hyperproteinorrhachia-causing-shunt-failures-and-nonobstructive-hydrocephalus-report-of-successful-treatment-with-long-term-follow-up
#15
Ekkehard Kasper, Yosef Laviv, Mohammed-Adeeb E Sebai, Ning Lin, William Butler
Subependymal giant cell astrocytomas (SEGAs) are histologically benign tumors most frequently associated with tuberous sclerosis complex (TSC). Despite their benign histopathological appearance, they may cause unfavorable outcomes due to their intraventricular location. Rarely, SEGA may be associated with hyperproteinorrhachia (high levels of proteins in the cerebrospinal fluid [CSF]), which causes malresorptive, communicating hydrocephalus; certainly, this scenario makes shunt obstruction likely in this patient population...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29112409/trends-in-strong-chemical-bonding-in-c2-cn-cn-co-n2-no-no-and-o2
#16
Kasper P Kepp
The strong chemical bonds between C, N, and O play a central role in chemistry, and their formation and cleavage are critical steps in very many catalytic processes. The close-lying molecular orbital energies and large correlation effects pose a challenge to electronic structure calculations and have led to different bonding interpretations, most notably for C2. One way to approach this problem is by strict benchmark comparison of related systems. This work reports reference electronic structures and computed bond dissociation enthalpies D0 for C2, CN, CN(-), CO, N2, NO, NO(+), O2 and related systems C2(+) and C2(-) at chemical accuracy (∼1 kcal/mol or 4 kJ/mol) using CCSD(T)/aug-cc-pV5Z, with additional benchmarks of HF, MP2, CCSD, explicitly correlated F12 methods, and four density functionals...
November 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29111868/editorial
#17
Siegfried Kasper
No abstract text is available yet for this article.
December 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29109275/engineering-of-a-membrane-triggered-activity-switch-in-coagulation-factor-viia
#18
Anders L Nielsen, Anders B Sorensen, Heidi L Holmberg, Prafull S Gandhi, Johan Karlsson, Jens Buchardt, Kasper Lamberth, Mads Kjelgaard-Hansen, Carsten Dan Ley, Brit B Sørensen, Wolfram Ruf, Ole H Olsen, Henrik Østergaard
Recombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the treatment of bleeding episodes in patients with inhibitor-complicated hemophilia. Here, an approach was adopted to enhance the activity of FVIIa by selectively optimizing substrate turnover at the membrane surface. Under physiological conditions, endogenous FVIIa engages its cell-localized cofactor tissue factor (TF), which stimulates activity through membrane-dependent substrate recognition and allosteric effects...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29108799/corrigendum-to-remote-management-of-low-to-intermediate-risk-chest-pain-a-case-series-am-j-emerg-med-2017
#19
Alexander Chiu, Kathleen Shumaker, Christopher Del Corral, Blessy George, Michael Kasper, Marie-Carmelle Elie-Turenne, Preeti Jois, Daniel Dipsia, Meaghan Donnelly, Lauren Sidow, Caroline Chau, Adam Ash
No abstract text is available yet for this article.
November 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29108280/trimethylation-of-h3k27-during-human-cerebellar-development-in-relation-to-medulloblastoma
#20
Shahryar E Mir, Michiel Smits, Dennis Biesmans, Machteld Julsing, Marianna Bugiani, Eleonora Aronica, Gertjan J L Kaspers, Jacqueline Cloos, Thomas Würdinger, Esther Hulleman
Medulloblastoma (MB), the most common malignant childhood brain tumor, encompasses a collection of four clinically and molecularly distinct tumor subgroups, i.e. WNT, SHH, Group 3 and Group 4. These tumors are believed to originate from precursor cells during cerebellar development. Although the exact etiology of these brain tumors is not yet known, histone modifications are increasingly recognized as key events during cerebellum development and MB tumorigenesis. Recent studies show that key components involved in post-translational modifications of histone H3 lysine 27 (H3K27) are commonly deregulated in MB...
October 3, 2017: Oncotarget
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