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https://www.readbyqxmd.com/read/29340622/comment-on-cryofibrinogenaemia-a-neglected-disease
#1
François Rodrigues, Claude Bachmeyer
No abstract text is available yet for this article.
January 11, 2018: Rheumatology
https://www.readbyqxmd.com/read/29340464/seroprevalence-of-human-trypanosoma-cruzi-infection-in-the-north-of-estado-de-mexico
#2
Saúl González-Guzmán, Sergio Pichardo-Ávila, Eulalia Mimbrera-Rodríguez, José Antonio Crescencio-Trujillo, María de Lourdes Gasca-Leyva, Fernando Martínez-Hernández, Nancy Rivas, Ricardo Alejandre-Aguilar
INTRODUCTION: Chagas disease is a neglected public health problem in Mexico; however, detailed studies to determine the seroprevalence in some states have not been performed. METHODS: A total 1,504 human serum from thirteen communities in Estado de Mexico, were analyzed with three diagnostics techniques. RESULTS: The overall seroprevalence was 9.1%, with high prevalence among people aged 51-60 years, while people aged 0-29 years were seronegative against T...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29339220/a-new-chimeric-triple-reporter-fusion-protein-as-a-tool-for-in-vitro-and-in-vivo-multimodal-imaging-to-monitor-the-development-of-african-trypanosomes-and-leishmania-parasites
#3
Estefania Calvo Alvarez, Christelle Cren-Travaillé, Aline Crouzols, Brice Rotureau
Trypanosomiases and leishmaniases, caused by a group of related protist parasites, are Neglected Tropical Diseases currently threatening >500 million people worldwide. Reporter proteins have revolutionised the research on infectious diseases and have opened up new advances in the understanding of trypanosomatid-borne diseases in terms of both biology, pathogenesis and drug development. Here, we describe the generation and some applications of a new chimeric triple reporter fusion protein combining the red-shifted firefly luciferase PpyREH9 and the tdTomato red fluorescent protein, fused by the TY1 tag...
January 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29337988/l-arginine-supplementation-reduces-mortality-and-improves-disease-outcome-in-mice-infected-with-trypanosoma-cruzi
#4
Sofía Carbajosa, Héctor O Rodríguez-Angulo, Susana Gea, Carlos Chillón-Marinas, Cristina Poveda, María C Maza, Diana Colombet, Manuel Fresno, Núria Gironès
Chagas disease caused by Trypanosoma cruzi is a neglected disease that affects about 7 million people in Latin America, recently emerging on other continents due to migration. As infection in mice is characterized by depletion of plasma L-arginine, the effect on infection outcome was tested in mice with or without L-arginine supplementation and treatment with 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS). We found that levels of L-arginine and citrulline were reduced in the heart and plasma of infected mice, whereas levels of asymmetric dimethylarginine, an endogenous iNOS inhibitor, were higher...
January 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29337909/salvia-species-as-sources-of-natural-products-with-antiprotozoal-activity
#5
REVIEW
Núria Llurba-Montesino, Thomas J Schmidt
Natural products from plants have been used since ancestral times to treat a wide variety of diseases worldwide. Plants of the genus Salvia (Sage) have been reported to be used for the prevention and treatment of various diseases and ailments. In particular, some Salvia species have been used in traditional medicine to treat diseases caused by protozoan parasites of the genera Trypanosoma, Leishmania and Plasmodium and scientific studies have demonstrated the activity of various isolated constituents from these plants against these pathogens...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336516/neglect-of-attention-to-reproductive-health-in-women-with-hiv-infection-contraceptive-use-and-unintended-pregnancies-in-the-swiss-hiv-cohort-study
#6
K Aebi-Popp, V Mercanti, C Voide, J Nemeth, A Cusini, B Jakopp, D Nicca, M Rasi, A Bruno, A Calmy, B Martinez de Tejada
OBJECTIVES: Women with HIV infection are mainly of reproductive age and need safe, effective and affordable contraception to avoid unintended pregnancies. The aim of this study was to evaluate contraceptive use and unintended pregnancies in this population in Switzerland. METHODS: A self-report anonymous questionnaire on contraceptive methods, adherence to them, and unintended pregnancies was completed by women included in the Swiss HIV Cohort Study (SHCS) between November 2013 and June 2014...
January 16, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29335834/genetics-of-osteopetrosis
#7
REVIEW
Eleonora Palagano, Ciro Menale, Cristina Sobacchi, Anna Villa
PURPOSE OF REVIEW: The term osteopetrosis refers to a group of rare skeletal diseases sharing the hallmark of a generalized increase in bone density owing to a defect in bone resorption. Osteopetrosis is clinically and genetically heterogeneous, and a precise molecular classification is relevant for prognosis and treatment. Here, we review recent data on the pathogenesis of this disorder. RECENT FINDINGS: Novel mutations in known genes as well as defects in new genes have been recently reported, further expanding the spectrum of molecular defects leading to osteopetrosis...
January 15, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29332141/cultivable-fungi-present-in-antarctic-soils-taxonomy-phylogeny-diversity-and-bioprospecting-of-antiparasitic-and-herbicidal-metabolites
#8
Eldon C Q Gomes, Valéria M Godinho, Débora A S Silva, Maria T R de Paula, Gislaine A Vitoreli, Carlos L Zani, Tânia M A Alves, Policarpo A S Junior, Silvane M F Murta, Emerson C Barbosa, Jaquelline G Oliveira, Fabio S Oliveira, Camila R Carvalho, Mariana C Ferreira, Carlos A Rosa, Luiz H Rosa
Molecular biology techniques were used to identify 218 fungi from soil samples collected from four islands of Antarctica. These consisted of 22 taxa of 15 different genera belonging to the Zygomycota, Ascomycota, and Basidiomycota. Mortierella, Antarctomyces, Pseudogymnoascus, and Penicillium were the most frequently isolated genera and Penicillium tardochrysogenum, Penicillium verrucosus, Goffeauzyma gilvescens, and Mortierella sp. 2 the most abundant taxa. All fungal isolates were cultivated using solid-state fermentation to obtain their crude extracts...
January 13, 2018: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29326521/surgical-management-of-large-radicular-cyst-associated-with-mandibular-deciduous-molar-using-platelet-rich-fibrin-augmentation-a-rare-case-report
#9
Vijaya S Dhote, Nilima R Thosar, Sudhindra M Baliga, Priyanti Dharnadhikari, Poonam Bhatiya, Punit Fulzele
Radicular cysts arising from deciduous teeth are rare and usually cause a large bony defect. Autologous platelet-rich fibrin (PRF) is an easily available healing biomaterial in oral surgical defect with the new perspective of accelerated healing of a large bony defect. The present case is of unusually large radicular associated with neglected carious mandibular deciduous second molar in 10-year-old girl and its surgical management with PRF augmentation as a healing biomaterial in the bony defect. One-year follow-up showed uneventful healing and eruption of succedaneous tooth...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29325516/brucellosis-remains-a-neglected-disease-in-the-developing-world-a-call-for-interdisciplinary-action
#10
K A Franc, R C Krecek, B N Häsler, A M Arenas-Gamboa
BACKGROUND: Brucellosis is an endemic zoonotic disease in most of the developing world that causes devastating losses to the livestock industry and small-scale livestock holders. Infected animals exhibit clinical signs that are of economic significance to stakeholders and include reduced fertility, abortion, poor weight gain, lost draught power, and a substantial decline in milk production. In humans, brucellosis typically manifests as a variety of non-specific clinical signs. Chronicity and recurring febrile conditions, as well as devastating complications in pregnant women are common sequelae...
January 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29324858/mapping-the-geographical-distribution-of-podoconiosis-in-cameroon-using-parasitological-serological-and-clinical-evidence-to-exclude-other-causes-of-lymphedema
#11
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29324760/bionomics-of-phlebotomus-argentipes-in-villages-in-bihar-india-with-insights-into-efficacy-of-irs-based-control-measures
#12
David M Poché, Rajesh B Garlapati, Shanta Mukherjee, Zaria Torres-Poché, Epco Hasker, Tahfizur Rahman, Aakanksha Bharti, Vishnu P Tripathi, Suman Prakash, Rahul Chaubey, Richard M Poché
BACKGROUND: Visceral leishmaniasis (VL) is a deadly vector-borne disease. Approximately 90% of Indian VL cases occur in Bihar, where the sand fly, Phlebotomus argentipes, is the principal vector. Sand fly control in Bihar consists of indoor residual spraying (IRS), the practice of spraying the inner walls of village dwellings with insecticides. Prior researchers have evaluated success of IRS-control by estimating vector abundance in village houses, but the number of sampling periods (n = 2-3) were minimal, and outdoor-resting P...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29324739/mansonella-perstans-microfilaremic-individuals-are-characterized-by-enhanced-type-2-helper-t-and-regulatory-t-and-b-cell-subsets-and-dampened-systemic-innate-and-adaptive-immune-responses
#13
Manuel Ritter, Winston Patrick Chounna Ndongmo, Abdel Jelil Njouendou, Nora Nganyewo Nghochuzie, Lucy Cho Nchang, Dizzle Bita Tayong, Kathrin Arndts, Norman Nausch, Marc Jacobsen, Samuel Wanji, Laura E Layland, Achim Hoerauf
The filarial nematode Mansonella perstans is endemic throughout Africa, northern South America and the Caribbean. Interestingly, M. perstans-infected individuals present no distinct clinical picture associated with certain pathology. Due to its relatively silent nature, research on this tropical disease has been neglected, especially M. perstans-driven immune responses. A hindrance in obtaining data on M. perstans-specific responses has been the inability to obtain adult worms since their habitats in serous cavities are difficult to access...
January 11, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29322865/a-mathematical-model-of-tumour-growth-with-beddington-deangelis-functional-response-a-case-of-cancer-without-disease
#14
Hsiu-Chuan Wei
A previously published mathematical model, governing tumour growth with mixed immunotherapy and chemotherapy treatments, is modified and studied. The search time, which is assumed to be neglectable in the previously published model, is incorporated into the functional response for tumour-cell lysis by effector cells. The model exhibits bistability where a tumour-cell population threshold exists. A tumour with an initial cell population below the threshold can be controlled by the immune system and remains microscopic and asymptomatic called cancer without disease while that above the threshold grows to lethal size...
December 2018: Journal of Biological Dynamics
https://www.readbyqxmd.com/read/29320544/diversity-patterns-leishmania-dna-detection-and-bloodmeal-identification-of-phlebotominae-sand-flies-in-villages-in-northern-colombia
#15
Camila González, Cielo León, Andrea Paz, Marla López, Gisell Molina, Diana Toro, Mario Ortiz, Juan Manuel Cordovez, María Claudia Atencia, Germán Aguilera, Catalina Tovar
Leishmaniases are neglected tropical diseases exhibiting complex transmission cycles due to the number of parasite species circulating, sand fly species acting as vectors and infected mammals, including humans, which are defined in the New World as accidental hosts. However, current transmission scenarios are changing, and the disease is no longer exclusively related to forested areas but urban transmission foci occur, involving some species of domestic animals as suspected reservoirs. The aim of this study was to determine the transmission cycles in urban environments by evaluating sand fly diversity, detection of Leishmania DNA, and bloodmeal sources through intra and peridomestic collections...
2018: PloS One
https://www.readbyqxmd.com/read/29317889/clinical-and-laboratory-analysis-of-patients-with-leishmaniasis-a-retrospective-study-from-a-tertiary-care-center-in-new-delhi
#16
Nitin Gupta, Kamla Kant, Bijay Ranjan Mirdha
Background: Leishmaniasis manifests as visceral (VL), cutaneous (CL) or a dermal sequel of VL, known as Post kala-azar dermal leishmaniasis (PKDL). The aim of the study was to analyze the clinical and laboratory features of cases diagnosed with leishmaniasis. Methods: This hospital-based retrospective study included all cases of VL, PKDL, and CL diagnosed between Jan 2011 to Jan 2016 at All India Institute of Medical Sciences, New Delhi. Clinical and laboratory profile of the diagnosed cases were analyzed in detail...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317800/leishmaniasis-in-humans-drug-or-vaccine-therapy
#17
REVIEW
Masoud Ghorbani, Ramin Farhoudi
Leishmania is an obligate intracellular pathogen that invades phagocytic host cells. Approximately 30 different species of Phlebotomine sand flies can transmit this parasite either anthroponotically or zoonotically through their bites. Leishmaniasis affects poor people living around the Mediterranean Basin, East Africa, the Americas, and Southeast Asia. Affected regions are often remote and unstable, with limited resources for treating this disease. Leishmaniasis has been reported as one of the most dangerous neglected tropical diseases, second only to malaria in parasitic causes of death...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29315432/the-unbearable-lightness-of-being-malnourished-severe-acute-malnutrition-remains-a-neglected-tropical-disease
#18
Indi Trehan, Quique Bassat
No abstract text is available yet for this article.
January 5, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29313667/design-and-synthesis-of-broad-spectrum-trypanosomatid-selective-inhibitors
#19
Andrew L Fraser, Stefanie K Menzies, Elizabeth F B King, Lindsay B Tulloch, Eoin R Gould, Marija Zacharova, Terry K Smith, Gordon J Florence
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern that have a devastating effect on the developing world due to their burden on human and animal health. In this work, we detail the preparation of a focused library of substituted-tetrahydropyran derivatives and their evaluation as selective chemical tools for trypanosomatid inhibition and the follow-on development of photo-affinity probes capable of labeling target protein(s) in vitro. Several of these functionalised compounds maintain low micromolar activity against Trypanosoma brucei, Trypanosoma cruzi, Leishmania major and Leishmania donovani...
January 9, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29313513/diseases-due-to-intestinale-protozoa-diagnosed-at-le-dantec-university-hospital-in-dakar-senegal-from-2011-to-2015
#20
K Diongue, M Ndiaye, M C Seck, M A Diallo, Y D Ndiaye, A S Badiane, D Ndiaye
To identify the protozoa responsible for intestinal parasitosis diagnosed at Le Dantec University Hospital in Dakar, Senegal. The retrospective study included 2578 patients for whom stool samples were analyzed from 2011 to 2015. The sex ratio was 1.1. Patients' mean age was 28.5 years, with a range of 11 days to 91 years. Direct examination and the Ritchie technique were performed to search for parasites. In total, 317 patients had intestinal protozoa, for a prevalence of 12.3 %. Infections involved one (91%) or two parasites (9%)...
November 1, 2017: Médecine et Santé Tropicales
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