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https://www.readbyqxmd.com/read/28636445/developing-a-casper-survey-to-assess-the-prevalence-of-risk-factors-for-neglected-tropical-diseases-in-texas
#1
Seth Smitherman, Tracy Hammond, Daniel Goldberg, Jennifer Horney
While more than a billion people live at risk of neglected tropical diseases in areas of Asia, sub-Saharan Africa, and Latin America, the degree to which such diseases burden countries like the United States is currently unclear. Even though many neglected tropical diseases such as dengue, leishmaniasis, and Chagas disease are not endemic to the United States, the possibility of their emergence is noteworthy, especially in states like Texas, which has high levels of poverty, a large immigrant population, and a climate amenable to the vectors for these diseases and is geographically proximate to endemic areas...
May 2017: Health Security
https://www.readbyqxmd.com/read/28631489/an-update-on-the-recognition-and-treatment-of-autonomic-symptoms-in-parkinson-s-disease
#2
Wolfgang H Jost
Parkinson's disease (PD) is characterized by motor, autonomic, and neuropsychiatric symptoms. These occur in varying degrees in all stages of the disease. Among the autonomic disorders, cardiovascular, urogenital, gastrointestinal and thermoregulatory disorders are the most relevant. Within cardiovascular disorders drop of blood pressure after orthostasis and non-dipper behavior are very important; but also the influence of cardiovascular medication. Urgency, nocturia, and incontinence are of particular note within the urological problems...
June 20, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28630463/the-role-of-antibody-v%C3%AE%C2%BA-framework-3-region-towards-antigen-binding-effects-on-recombinant-production-and-protein-l-binding
#3
Chinh Tran-To Su, Wei-Li Ling, Wai-Heng Lua, Jun-Jie Poh, Samuel Ken-En Gan
Antibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and secretion. In the light chain, the complementarity-determining region 3 (VL-CDR3) is specifically implicated in disease states. By modulating VL-CDR3 exposure on the scaffold through deletions in the framework region 3 (VL-FWR3), we further investigated the effects on secretion in recombinant production and antigen binding kinetics. Our random deletions of two residues in the VL-FWR3 of a Trastuzumab model showed that the single deletions could impact recombinant production without significant effect on Her2 binding...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630200/treatment-of-experimental-visceral-leishmaniasis-with-single-dose-liposomal-amphotericin-b-pharmacodynamics-and-biodistribution-at-different-stages-of-disease
#4
Andrew A Voak, Andy Harris, Zeeshan Qaiser, Simon L Croft, Karin Seifert
Visceral leishmaniasis is a neglected tropical disease, which causes significant morbidity and mortality worldwide. Characterising the pharmacokinetics and pharmacodynamics of anti-leishmanial drugs in pre-clinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug distribution of AmBisome® in L. donovani infected BALB/c mice at three different dose levels and two different time points after infection. We additionally compared drug levels in plasma, liver and spleen in infected and uninfected BALB/c mice over time...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28630127/deciphering-function-of-new-gonococcal-vaccine-antigens-using-phenotypic-microarrays
#5
Benjamin I Baarda, Sarah Emerson, Philip J Proteau, Aleksandra E Sikora
The function and extracellular location of cell envelope proteins make them attractive candidates for developing vaccines against bacterial diseases, including challenging, drug-resistant pathogens such as Neisseria gonorrhoeae Proteomics-driven reverse vaccinology delivered multiple gonorrhea vaccine candidates; however, the biological functions of many of them remain to be elucidated. Herein, the functions of six gonorrhea vaccine candidates - NGO2121, NGO1985, NGO2054, NGO2111, NGO1205, and NGO1344 - in cell envelope homeostasis were probed using phenotype microarrays with 1,056 conditions and a ΔbamE mutant (Δngo1780) as a reference of perturbed outer membrane integrity...
June 19, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28629155/repositioning-fda-drugs-as-potential-cruzain-inhibitors-from-trypanosoma-cruzi-virtual-screening-in-vitro-and-in-vivo-studies
#6
Isidro Palos, Edgar E Lara-Ramirez, Julio Cesar Lopez-Cedillo, Carlos Garcia-Perez, Muhammad Kashif, Virgilio Bocanegra-Garcia, Benjamin Nogueda-Torres, Gildardo Rivera
Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic infections; therefore, the need to discover new drugs is essential. A computer-guided drug repositioning method was applied to identify potential FDA drugs (approved and withdrawn) as cruzain (Cz) inhibitors and trypanocidal effects were confirmed by in vitro and in vivo studies...
June 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28626451/dependency-of-b-1-cells-in-the-maintenance-of-splenic-interleukin-10-producing-cells-and-impairment-of-macrophage-resistance-in-visceral-leishmaniasis
#7
Angélica Fernandes Arcanjo, Dirlei Nico, Gabriellen Menezes Migliani de Castro, Yasmin da Silva Fontes, Paula Saltarelli, Debora Decote-Ricardo, Marise P Nunes, Antônio Ferreira-Pereira, Clarisa B Palatnik-de-Sousa, Célio G Freire-de-Lima, Alexandre Morrot
Visceral leishmaniasis is a neglected disease caused by Leishmania protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infection-induced host immunodeviation is the characteristic high levels of the regulatory interleukin-10 (IL-10) cytokine. In the present study, we investigated the role of B-1 cells in the maintenance of splenic IL-10 levels that could interfere with resistance to parasite infection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28625102/spatiotemporal-meta-analysis-reviewing-health-psychology-phenomena-over-space-and-time
#8
Blair T Johnson, Ellen K Cromley, Natasza Marrouch
Individual studies of health psychology are samples taken in particular places at particular times. The results of such studies manifest multiple processes, including those associated with individual, sample, intervention, and study design characteristics. Although extant meta-analyses of health phenomena have routinely considered these factors to explain heterogeneity, they have tended to neglect the environments where studies are conducted, which is ironic, as health phenomena cluster in space and times (e...
June 18, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28622437/detection-of-halitosis-in-breath-between-the-past-present-and-future
#9
Morad K Nakhleh, Marceau Quatredeniers, Hossam Haick
In order to develop a new generation of diagnostics for halitosis, replacing the subjective organoleptic assessment, a series of exhaled breath analyzers has been developed and assessed. All three devices rely on the assessment of exhaled Volatile Sulfuric Compounds (VSCs), which are mainly generated in and emitted from the oral cavity, contributing to the malodor. Portable, on-site and easy to use, these devices have potential for non-invasive diagnosis of halitosis. However, global assessment of exhaled VSCs alone has two main drawbacks: (1) the absence of VCSs does not rule out halitosis; (2) non-sulfuric volatile compounds that could be biomarkers of systemic diseases, found in up to 15% of halitosis cases, are neglected...
June 16, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28622332/comparison-of-monocyte-gene-expression-among-patients-with-neurocysticercosis-associated-epilepsy-idiopathic-epilepsy-and-idiopathic-headaches-in-india
#10
Vasudevan Prabhakaran, Douglas A Drevets, Govindan Ramajayam, Josephine J Manoj, Michael P Anderson, Jay S Hanas, Vedantam Rajshekhar, Anna Oommen, Hélène Carabin
BACKGROUND: Neurocysticercosis (NCC), a neglected tropical disease, inflicts substantial health and economic costs on people living in endemic areas such as India. Nevertheless, accurate diagnosis using brain imaging remains poorly accessible and too costly in endemic countries. The goal of this study was to test if blood monocyte gene expression could distinguish patients with NCC-associated epilepsy, from NCC-negative imaging lesion-free patients presenting with idiopathic epilepsy or idiopathic headaches...
June 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28620610/molecular-detection-of-tick-borne-pathogen-diversities-in-ticks-from-livestock-and-reptiles-along-the-shores-and-adjacent-islands-of-lake-victoria-and-lake-baringo-kenya
#11
David Omondi, Daniel K Masiga, Burtram C Fielding, Edward Kariuki, Yvonne Ukamaka Ajamma, Micky M Mwamuye, Daniel O Ouso, Jandouwe Villinger
Although diverse tick-borne pathogens (TBPs) are endemic to East Africa, with recognized impact on human and livestock health, their diversity and specific interactions with tick and vertebrate host species remain poorly understood in the region. In particular, the role of reptiles in TBP epidemiology remains unknown, despite having been implicated with TBPs of livestock among exported tortoises and lizards. Understanding TBP ecologies, and the potential role of common reptiles, is critical for the development of targeted transmission control strategies for these neglected tropical disease agents...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28620563/pharmacological-threat-to-lungs-a-case-series-and-literature-review
#12
REVIEW
Omar Irfan, Jaleed A Gilani, Abeel Irshad, Babar Irfan, Javaid A Khan
Drug-induced organ damage stands as a prevalent yet much-neglected issue globally. Keeping in view it's rising frequency, health care providers stand obliged to be well versed with the de-merits of the agents they prescribe. Drug therapies causing damage present with a non-specific clinical presentation, histological findings or radiology, which further elaborates on the necessity of a conscientious diagnosis. Pulmonary architecture ranging from the airways, lung parenchyma, mediastinum, pleura, pulmonary vasculature or the neuromuscular system, all can fall victim to the dreaded outcomes of this menace...
May 9, 2017: Curēus
https://www.readbyqxmd.com/read/28620305/comparative-effects-of-chloride-channel-inhibitors-on-lrrc8-vrac-mediated-chloride-conductance
#13
Jonas Friard, Michel Tauc, Marc Cougnon, Vincent Compan, Christophe Duranton, Isabelle Rubera
Chloride channels play an essential role in a variety of physiological functions and in human diseases. Historically, the field of chloride channels has long been neglected owing to the lack of powerful selective pharmacological agents that are needed to overcome the technical challenge of characterizing the molecular identities of these channels. Recently, members of the LRRC8 family have been shown to be essential for generating the volume-regulated anion channel (VRAC) current, a chloride conductance that governs the regulatory volume decrease (RVD) process...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28619684/is-usutu-virus-ready-for-prime-time
#14
EDITORIAL
Jason A Tetro
Although considered a neglected tropical disease, the mosquito-borne Usutu virus has demonstrated signs of emergence from Africa to Europe. While human cases are infrequent, the potential for neuroinvasive infection, even in immunocompetent individuals, suggests a need for increased research into virus biology and pathogenesis, as well as rapid measures for diagnosis and environmental surveillance.
June 12, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28619398/global-burden-of-disease-of-mercury-used-in-artisanal-small-scale-gold-mining
#15
Nadine Steckling, Myriam Tobollik, Dietrich Plass, Claudia Hornberg, Bret Ericson, Richard Fuller, Stephan Bose-O'Reilly
BACKGROUND: Artisanal small-scale gold mining (ASGM) is the world's largest anthropogenic source of mercury emission. Gold miners are highly exposed to metallic mercury and suffer occupational mercury intoxication. The global disease burden as a result of this exposure is largely unknown because the informal character of ASGM restricts the availability of reliable data. OBJECTIVE: To estimate the prevalence of occupational mercury intoxication and the disability-adjusted life years (DALYs) attributable to chronic metallic mercury vapor intoxication (CMMVI) among ASGM gold miners globally and in selected countries...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28617860/increasing-prevalence-of-infectious-diseases-in-asylum-seekers-at-a-tertiary-care-hospital-in-switzerland
#16
Constantine Bloch-Infanger, Veronika Bättig, Jürg Kremo, Andreas F Widmer, Adrian Egli, Roland Bingisser, Manuel Battegay, Stefan Erb
OBJECTIVE: The increasing number of refugees seeking asylum in Europe in recent years poses new challenges for the healthcare systems in the destination countries. The goal of the study was to describe the evolution of medical problems of asylum seekers at a tertiary care centre in Switzerland. METHODS: At the University Hospital Basel, we compared all asylum seekers during two 1-year time periods in 2004/05 and 2014/15 concerning demographic characteristics and reasons for referrals and hospitalizations...
2017: PloS One
https://www.readbyqxmd.com/read/28616499/emergence-of-wesselsbron-virus-among-black-rat-and-humans-in-eastern-senegal-in-2013
#17
Moussa M Diagne, Martin Faye, Oumar Faye, Abdourahmane Sow, Fanny Balique, Mbacké Sembène, Laurent Granjon, Pascal Handschumacher, Ousmane Faye, Mawlouth Diallo, Amadou A Sall
Wesselsbron disease is a neglected mosquito transmitted Flavivirus infection that causes abortions and has teratogenic effects on sheep and cattle in Africa. Human can also be infected. The detection of human or animal cases is complicated by the non-specific symptoms close to Rift Valley Fever (RVF) in domestic livestock species or Dengue like syndrome in humans. Then, these detections are usually made during RVF investigations in sheep. These domestic animals should take a role in the life cycle of the virus but some evidences of Wesselsbron virus (WSLV) presence in wild animals suggest that the latter may be involved in the virus maintenance in nature...
June 2017: One Health
https://www.readbyqxmd.com/read/28611925/prevalence-and-correlates-of-intestinal-parasites-among-patients-admitted-to-mirembe-national-mental-health-hospital-dodoma-tanzania
#18
Azan A Nyundo, David Z Munisi, Ainory P Gesase
BACKGROUND: Neglected tropical diseases continue to be one of the leading causes of morbidity and mortality in the developing world. Psychiatric patients are among groups at risk for parasitic infection although control and monitoring programs largely overlook this population. This study aimed at determining prevalence and factors associated with intestinal parasitic infection among patients admitted to a psychiatric facility. METHOD: The study followed cross-sectional design; all the residing patients that met the inclusion criteria were included in the survey...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28609703/etiologic-classification-of-ischemic-stroke-where-do-we-stand
#19
REVIEW
Răzvan Alexandru Radu, Elena Oana Terecoasă, Ovidiu Alexandru Băjenaru, Cristina Tiu
Despite major technological advances in ischemic stroke diagnostic techniques, our current understanding of stroke mechanisms and etiology continues to remain unclear in a significant percent of patients. As a result, several etiological ischemic stroke classifications have emerged during the last two decades but their reliability and validity is far from perfect and further world-wide research is needed in order to achieve the so much needed "standard reference language". An ideal ischemic stroke classification should both comprise all underlying pathologies that could potentially concur to an index event and emphasize the most likely etiological and pathophysiological mechanism...
May 24, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28606408/-common-therapeutic-approaches-of-sarcopenia-in-the-elderly-and-uremic-myopathy
#20
Philippe Chauveau, Karine Moreau, Catherine Lasseur, Christian Combe, Michel Aparicio
The gradual loss of weight and function of muscle in patients with chronic kidney disease as in the elderly impacts the quality of life. Early management should help slow the functional limitation. Physical activity is the first therapy to propose that ensures stability of muscle mass and improved function. Resistance training programs have proven effective but are not yet widely available in nephrology units. The nutritional management should not be forgotten because there is a resistance to anabolism and protein intake should be involved in physical activity program...
June 9, 2017: Néphrologie & Thérapeutique
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