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https://www.readbyqxmd.com/read/28743005/xenopus-laevis-m18bp1-directly-binds-existing-cenp-a-nucleosomes-to-promote-centromeric-chromatin-assembly
#1
Bradley T French, Frederick G Westhorpe, Charles Limouse, Aaron F Straight
Vertebrate centromeres are epigenetically defined by nucleosomes containing the histone H3 variant, CENP-A. CENP-A nucleosome assembly requires the three-protein Mis18 complex (Mis18α, Mis18β, and M18BP1) that recruits the CENP-A chaperone HJURP to centromeres, but how the Mis18 complex recognizes centromeric chromatin is unknown. Using Xenopus egg extract, we show that direct, cell-cycle-regulated binding of M18BP1 to CENP-A nucleosomes recruits the Mis18 complex to interphase centromeres to promote new CENP-A nucleosome assembly...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742972/stimuli-responsive-directional-vesicular-assembly-with-tunable-surface-functionality-and-impact-on-enzyme-inhibition
#2
Amrita Sikder, Debes Ray, Vinod Kumar Aswal, Suhrit Ghosh
The article describes self-assembly of a series of unsymmetrical bola-shape π-amphiphiles (NDI-1, NDI-1a, NDI-2, NDI-3 and NDI-4) consisting of a hydrophobic naphthalene-diimide (NDI) chromophore attached with a non-ionic hydrophilic wedge and an anionic head group in the two opposite arms of the central NDI. By design only a single hydrazide group is linked either on the ionic or non-ionic arm of the NDI. NDI-1 and NDI-1a are regioisomers differing only in the location of the hydrazide group, placed in the non-ionic or ionic arm, respectively...
July 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28742950/becoming-independent-political-participation-and-youth-transitions-in-the-scottish-referendum
#3
Maddie Breeze, Hugo Gorringe, Lynn Jamieson, Michael Rosie
Sociological debates on youth engagement with electoral politics play out against a backdrop of supposed 'decline' in civic participation (e.g. Putnam , Norris, ), in turn contextualized by theories of individualization in 'late' or 'reflexive' modernity (Beck, Giddens). However, the enfranchisement of 16 and 17 year olds in the 2014 Scottish Independence Referendum catalysed remarkably high levels of voter turnout among this youngest group, and was accompanied by apparently ongoing political engagement. We explored this engagement among a strategic sample of young 'Yes' voters, in the immediate aftermath of this exceptional political event...
July 25, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28742863/antibacterial-activity-of-tannins-isolated-from-sapium-baccatum-extract-and-use-for-control-of-tomato-bacterial-wilt
#4
Thuy Thu Vu, Hun Kim, Vu Khac Tran, Hoang Dinh Vu, Tien Xuan Hoang, Jae Woo Han, Yong Ho Choi, Kyoung Soo Jang, Gyung Ja Choi, Jin-Cheol Kim
In the search for new antibacterial agents from natural sources, we revealed that a crude methanol extract of Sapium baccatum was highly active against Ralstonia solanacearum, a causal agent of a serious disease called bacterial wilt of tomato. The bioassay-guided fractionation of this extract resulted in the isolation of seven known active compounds, including gallic acid, methyl gallate, corilagin, tercatain, chebulagic acid, chebulinic acid, and quercetin 3-O-α-L-arabinopyranoside. Their chemical structures were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28742856/fit-for-genomic-and-proteomic-purposes-sampling-the-fitness-of-nucleic-acid-and-protein-derivatives-from-formalin-fixed-paraffin-embedded-tissue
#5
Anna Yakovleva, Jordan L Plieskatt, Sarah Jensen, Razan Humeida, Jonathan Lang, Guangzhao Li, Paige Bracci, Sylvia Silver, Jeffrey Michael Bethony
The demand for nucleic acid and protein derivatives from formalin-fixed paraffin-embedded (FFPE) tissue has greatly increased due to advances in extraction and purification methods, making these derivatives available for numerous genomic and proteomic platforms. Previously, DNA, RNA, microRNA (miRNA), or protein derived from FFPE tissue blocks were considered "unfit" for such platforms, as the process of tissue immobilization by FFPE resulted in cross-linked, fragmented, and chemically modified macromolecules...
2017: PloS One
https://www.readbyqxmd.com/read/28742854/risk-of-exposure-to-potential-vector-mosquitoes-for-rural-workers-in-northern-lao-pdr
#6
Julie-Anne A Tangena, Phoutmany Thammavong, Steve W Lindsay, Paul T Brey
BACKGROUND: One major consequence of economic development in South-East Asia has been a rapid expansion of rubber plantations, in which outbreaks of dengue and malaria have occurred. Here we explored the difference in risk of exposure to potential dengue, Japanese encephalitis (JE), and malaria vectors between rubber workers and those engaged in traditional forest activities in northern Laos PDR. METHODOLOGY/PRINCIPAL FINDINGS: Adult mosquitoes were collected for nine months in secondary forests, mature and immature rubber plantations, and villages...
July 25, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28742843/sequencing-of-the-complete-mitochondrial-genomes-of-eight-freshwater-snail-species-exposes-pervasive-paraphyly-within-the-viviparidae-family-caenogastropoda
#7
Ju-Guang Wang, Dong Zhang, Ivan Jakovlić, Wei-Min Wang
Phylogenetic relationships among snails (Caenogastropoda) are still unresolved, and many taxonomic categories remain non-monophyletic. Paraphyly has been reported within a large family of freshwater snails, Viviparidae, where the taxonomic status of several species remains questionable. As many endemic Chinese viviparid species have become endangered during the last few decades, this presents a major obstacle for conservation efforts. Mitochondrial genomes (mitogenomes) carry a large amount of data, so they can often provide a much higher resolution for phylogenetic analyses in comparison to the traditionally used molecular markers...
2017: PloS One
https://www.readbyqxmd.com/read/28742793/intracrine-vegf-signalling-mediates-colorectal-cancer-cell-migration-and-invasion
#8
Rajat Bhattacharya, Fan Fan, Rui Wang, Xiangcang Ye, Ling Xia, Delphine Boulbes, Lee M Ellis
BACKGROUND: Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) are key regulators of angiogenesis, affecting endothelial cell survival and function. However, the effect of VEGF-VEGFR signalling on tumour cell function is not well understood. Our previous studies in colorectal cancer (CRC) cells have demonstrated an intracrine VEGF/VEGFR1 signalling mechanism that mediates CRC cell survival and chemo-sensitivity. Since extracellular VEGF signalling regulates migration of endothelial cells and various tumour cells, we attempted to determine whether intracrine VEGF signalling affects CRC cell motility...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28742757/concurrent-validity-and-responsiveness-of-promis-health-domains-among-patients-presenting-for-anterior-cervical-spine-surgery
#9
Taylor E Purvis, Elena Andreou, Brian J Neuman, Lee H Riley, Richard L Skolasky
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To determine validity and responsiveness of Patient-Reported Outcomes Measurement Information System (PROMIS) health domains. SUMMARY OF BACKGROUND DATA: PROMIS health domains (anxiety, depression, fatigue, pain, physical function, satisfaction with participation in social roles, sleep disturbance) may measure quality of care and determine minimal important differences (MIDs) after spine surgery...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742695/does-surgeon-sex-matter-practice-patterns-and-outcomes-of-female-and-male-surgeons
#10
Catherine E Sharoky, Morgan M Sellers, Luke J Keele, Christopher J Wirtalla, Giorgos C Karakousis, Jon B Morris, Rachel R Kelz
OBJECTIVE: We sought to compare postoperative outcomes of female surgeons (FS) and male surgeons (MS) within general surgery. SUMMARY OF BACKGROUND DATA: FS in the workforce are increasing in number. Female physicians provide exceptional care in other specialties. Differences in surgical outcomes of FS and MS have not been examined. METHODS: We linked the AMA Physician Masterfile to discharge claims from New York, Florida, and Pennsylvania (2012 to 2013) to examine practice patterns and to compare surgical outcomes of FS and MS...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742582/endometriosis-and-imaging
#11
Luis R Hoyos, Samuel Johnson, Elizabeth Puscheck
Endometriosis is a condition with variable location, size, and lesion composition which poses a diagnostic imaging challenge for the practicing gynecologist. Transvaginal ultrasound and magnetic resonance imaging are the most frequent imaging techniques used for its evaluation, but transvaginal ultrasound should be the first-line approach, as it is often sufficient, followed by modified ultrasound techniques. Magnetic resonance imaging should be considered when a diagnosis has not been achieved by sonographic means or when the renal system needs to be concurrently evaluated...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742485/a-new-morphological-trait-in-forensic-identification-middle-phalangeal-hair-mph
#12
Kewal Krishan, Tanuj Kanchan
Middle phalangeal hairs (MPH) are present on the dorsal aspect of the middle phalange of the fingers except for the thumb. The MPH have been of interest to anthropologists, human biologists, clinicians, geneticists and anatomists in the past as a morphological trait of the human body. The anthropological value of MPH is well established in studying population variations, with implications for age, ancestry and sex differences. We are of the opinion that MPH may be used significantly for forensic identification purposes along with other morphological characteristics of the human body...
December 1, 2016: Science Progress
https://www.readbyqxmd.com/read/28742467/polycystic-ovary-syndrome-in-adolescents-which-mr-imaging-based-diagnostic-criteria
#13
Maxime Fondin, Antoine Rachas, Van Huynh, Stéphanie Franchi-Abella, Jean-Paul Teglas, Lise Duranteau, Catherine Adamsbaum
Purpose To evaluate the validity and reproducibility of magnetic resonance (MR) imaging-based ovarian morphologic measurements for diagnosis of polycystic ovary syndrome (PCOS) in adolescents. Materials and Methods This case-control study included 110 adolescent girls (age range, 13-17 years) who underwent pelvic MR imaging in 2006-2015. The case group included girls with high (n = 40, hyperandrogenism and oligomenorrhea or amenorrhea), intermediate (n = 8, hyperandrogenism), or low (n = 7, oligomenorrhea or amenorrhea) suspicion of PCOS...
July 25, 2017: Radiology
https://www.readbyqxmd.com/read/28742253/precisely-designed-isopeptide-bridge-crosslinking-endows-artificial-hydrolases-with-predominant-stability-and-catalytic-activity-under-extreme-denaturing-conditions
#14
Yu Bai, Chao Wang, Guodong Liang, Wenqing Lai, Huifang Xue, Yanbo Ling, Maosheng Cheng, Keliang Liu
Enzymes normally lose their activities under extreme conditions due to the dissociation of their active tertiary structure. If an enzyme could maintain its catalytic activity under non physiological or denaturing conditions, it might be used in more applications in the pharmaceutical and chemical industries. Recently, we reported a coiled-coil six-helical bundle (6HB) structure as a scaffold for designing artificial hydrolytic enzymes. Here, intermolecular isopeptide bonds were incorporated to enhance the stability and activity of such biomolecules under denaturing conditions...
July 25, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28742114/a-unique-polysaccharide-purified-from-hericium-erinaceus-mycelium-prevents-oxidative-stress-induced-by-h2o2-in-human-gastric-mucosa-epithelium-cell
#15
Mingxing Wang, Nakajima Kanako, Yanqiu Zhang, Xulang Xiao, Qipin Gao, Konishi Tetsuya
Hericium erinaceus (HE) has been used both as a traditional Chinese medicine and home remedy for treatment of gastric and duodenal ulcers and gastritis. EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity. Because oxidative stress has been implicated as a pathogenic cause of gastritis and gastric ulcers, EP-1 antioxidant properties were systematically examined in vitro using the human gastric mucosal epithelial cell line, GES-1...
2017: PloS One
https://www.readbyqxmd.com/read/28742111/axonal-outgrowth-neuropeptides-expression-and-receptors-tyrosine-kinase-phosphorylation-in-3d-organotypic-cultures-of-adult-dorsal-root-ganglia
#16
Estrela Neto, Cecília J Alves, Luís Leitão, Daniela M Sousa, Inês S Alencastre, Francisco Conceição, Meriem Lamghari
Limited knowledge from mechanistic studies on adult sensory neuronal activity was generated, to some extent, in recapitulated adult in vivo 3D microenvironment. To fill this gap there is a real need to better characterize the adult dorsal root ganglia (aDRG) organotypic cultures to make these in vitro systems exploitable for different approaches, ranging from basic neurobiology to regenerative therapies, to address the sensory nervous system in adult stage. We conducted a direct head-to-head comparison of aDRG and embryonic DRG (eDRG) organotypic culture focusing on axonal growth, neuropeptides expression and receptors tyrosine kinase (RTK) activation associated with neuronal survival, proliferation and differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28742101/urban-rural-differences-in-disability-free-life-expectancy-in-bangladesh-using-the-2010-hies-data
#17
Md Shariful Islam, Md Ismail Tareque, Md Nazrul Islam Mondal, Ahbab Mohammad Fazle Rabbi, Hafiz T A Khan, Sharifa Begum
BACKGROUND: Research on health expectancy has been carried out in Bangladesh but none of it has examined the differences in Disability-Free Life Expectancy (DFLE) between urban and rural setting in context of rapid urbanization of Bangladesh in past decades. OBJECTIVES: The present study aims to estimate DFLE for people of all ages living in urban and rural areas in Bangladesh, and to examine the differences in DFLE between these two areas. METHODS: Data from the Sample Vital Registration System 2010 and the Bangladesh Household Income and Expenditure Survey (HIES) 2010 were used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28742046/a-fast-algorithm-for-analysis-of-molecular-communication-in-artificial-synapse
#18
Bilgesu A Bilgin, Ozgur B Akan
In this paper we analyse molecular communications (MC) in a proposed artificial synapse (AS), whose main difference from biological synapses (BSs) is that it is closed, i.e., transmitter molecules cannot diffuse out from AS. Such a setup has both advantages and disadvantages. Besides higher structural stability, being closed, AS never runs out of transmitters. Thus, MC in AS is disconnected from outer environment, which is very desirable for possible intra-body applications. On the other hand, clearance of transmitters from AS has to be achieved by transporter molecules on the presynaptic membrane of AS...
July 21, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28741965/cost-effectiveness-of-dolutegravir-abacavir-lamivudine-in-hiv-1-treatment-na%C3%A3-ve-tn-patients-in-france
#19
Gilles Pialoux, Anne-Geneviève Marcelin, Hélène Cawston, Caroline Guilmet, Laurent Finkielsztejn, Audrey Laurisse, Céline Aubin
OBJECTIVES: To evaluate the cost-effectiveness of an integrase inhibitor (INI), dolutegravir (DTG), in combination with abacavir (ABC)/lamivudine (3TC) in France, in treatment-naïve (TN) HIV adult patients. METHODS: The ARAMIS microsimulation Markov model, evaluates costs and effects of DTG vs. first-line ARVs options including INIs (raltegravir, elvitegravir/c), protease inhibitors (PIs) (darunavir/r, atazanavir/r, lopinavir/r), non-nucleoside reverse transcriptase inhibitors (efavirenz and rilpivirine)...
July 25, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28741960/retention-of-viability-of-salmonella-in-sucrose-as-affected-by-type-of-inoculum-water-activity-and-storage-temperature
#20
Larry R Beuchat, David A Mann, Christine A Kelly, Ynes R Ortega
Outbreaks of salmonellosis have been associated with consumption of high-sugar, low-water activity (aw) foods. The study reported here was focused on determining the effect of storage temperature (5 and 25°C) on survival of initially high and low levels of Salmonella in dry-inoculated sucrose (aw 0.26 ± 0.01 to 0.54 ± 0.01) and wet-inoculated sucrose (aw 0.24 ± 0.01 to 0.44 ± 0.04) over a 52-week period. With the exception of dry-inoculated sucrose at aw 0.26, Salmonella survived for 52 weeks in dry- and wet-inoculated sucrose stored at 5 and 25°C...
July 25, 2017: Journal of Food Protection
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