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https://www.readbyqxmd.com/read/29923067/hypertensive-disorders-of-pregnancy-and-cardiovascular-diseases-current-knowledge-and-future-directions
#1
REVIEW
Thais Coutinho, Olabimpe Lamai, Kara Nerenberg
PURPOSE OF THE REVIEW: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. RECENT FINDINGS: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29922434/gestational-diabetes-influences-the-expression-of-hypertrophic-genes-in-left-ventricle-of-rat-s-offspring
#2
Elia Saragard Kermani, Zahra Nazari, Mehdi Mehdizadeh, Majid Shahbazi, Mohammad Jafar Golalipour
Objectives: Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats. Materials and Methods: Diabetes was induced in 40 adult Wistar rats by intraperitoneal injection of 45 mg/kg of streptozotocin...
May 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29914284/congenital-heart-defects-the-10-year-experience-at-a-single-center
#3
Emine Aydin, Ebru Aypar, Ahmet Oktem, Ozgur Ozyuncu, Murat Yurdakok, Murat Guvener, Metin Demircin, M Sinan Beksac
OBJECTIVE: We aimed to evaluate congenital heart disease (CHD) cases according to EUROCAT subgroup classification that were diagnosed during the prenatal period in our center. METHODS: CHDs that were prenatally diagnosed using ultrasonography and confirmed by fetal echocardiography were reviewed over a 10-year period. Subgroup classification was finalized at the post-partum period in terms of the EUROCAT guide 1.3. Congenital heart defect subtypes and obstetric outcomes (gestational week at delivery, birth weight, gender, extracardiac structural abnormalities, karyotype results if performed) were analyzed...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#4
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29912235/-peripartum-cardiomyopathy-a-little-known-disease
#5
Angela Beatrice Scardovi, Renata De Maria
Peripartum cardiomyopathy (PPCM) is a relatively rare cardiac disease that manifests itself in the final stage of pregnancy and in the first months after delivery in women with no previous history of cardiovascular disease. The incidence of PPCM varies widely across geographic areas and seems to be on the rise as a result of increased awareness and socioeconomic changes. PPCM recognizes a still partially undefined multifactorial etiology. Various pathogenetic hypotheses have been proposed, that range from autoimmune mechanisms to myocarditis to the hormonal hypothesis for aberrant, antiangiogenic and cardiotoxic prolactin (PRL) production, apoptosis, prolonged exposure to tocolytic drugs, malnutrition and genetic predisposition...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29909950/-management-of-mitral-valve-stenosis-during-pregnancy-at-the-oran-university-hospital-center-about-83-cases
#6
N F Benatta, D D Batouche, M A Djazouli, S A Zelmat, T Merzouk, L Hammou
INTRODUCTION: The management of pregnancy in patients with mitral valve stenosis disease continues to pose a challenge to the clinician. OBJECTIVE: The aim of study was to evaluate the association between mitral valve stenosis and maternal and fetal out come. MATERIEL AND METHOD: Eighty-three pregnant women with mitral valve disease, followed-up from 2009 to 2012, were prospectively evaluated medical history, NYHA class assessment, ECG and echocardiography were performed during pregnancy and after delivery...
June 14, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29907426/maternal-obesity-as-a-risk-factor-for-the-development-of-total-anomalous-pulmonary-venous-connection-in-their-offspring
#7
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
June 12, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29899387/childhood-cardiovascular-health-and-subfertility-the-bogalusa-heart-study
#8
Yiping Wang, Xu Xiong, Lydia Bazzano, Emily W Harville
BACKGROUND: Although childhood cardiovascular risk can contribute to adult cardiovascular disease, and fertility and adult cardiovascular health are linked, the association between early-life cardiovascular risk and female infertility has not been studied. METHODS: A total of 1799 women participated in the Babies substudy of the Bogalusa Heart Study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, and insulin were age-standardized and examined as predictors of self-reported fertility difficulties using multivariable logistic regression with adjustment for confounders...
June 13, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29897824/the-risk-of-cardiovascular-disease-end-stage-renal-disease-and-stroke-in-post-partum-women-and-their-fetuses-after-a-hypertensive-pregnancy
#9
Mark W Cunningham, Babbette D LaMarca
Women with hypertensive pregnancy complications are at greater risk of developing cardiovascular disease (CVD), metabolic diseases, stroke, and end-stage renal disease later in life. Pregnancy complications not only effect the mother's long-term health, but also the health of the fetus immediately after delivery and into adulthood. The health of the fetus until adulthood can be influenced by developmental programming, in which the fetus is exposed to insults that will ultimately affect the growth of the offspring and increase the offspring's risk of developing hypertension, coronary heart disease, metabolic disease, and chronic kidney disease in adulthood...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29895845/associations-of-social-and-economic-and-pregnancy-exposures-with-blood-pressure-in-uk-white-british-and-pakistani-children-age-4-5
#10
Jane West, Debbie A Lawlor, Gillian Santorelli, Paul Collings, Peter H Whincup, Naveed A Sattar, Diane Farrar, John Wright
South Asians have higher rates of coronary heart disease (CHD) than White European individuals. Blood pressure (BP) is one of the most important risk factors for CHD and ethnic differences in BP have been identified in childhood. Early life exposures could explain some of these differences. We examined associations of family social and economic and maternal pregnancy exposures and BP at age 4/5 in 1644 White British and 1824 Pakistani mother-offspring pairs from the Born in Bradford study. We found that systolic BP was similar but diastolic BP was higher, in Pakistani compared to White British children (adjusted mean differences were -0...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29894301/quantification-of-fetal-myocardial-function-in-pregnant-women-with-diabetic-diseases-and-in-normal-controls-using-speckle-tracking-echocardiography-ste
#11
Nina Rolf, Laura Kerschke, Janina Braun, Maria Karina Falkenberg, Kerstin Hammer, Helen Ann Köster, Mareike Möllers, Kathrin Oelmeier de Murcia, Walter Klockenbusch, Ralf Schmitz
PURPOSE: The purpose of our study was to quantify the fetal myocardial function in pregnant women with diabetic diseases (FDM) and in normal controls (FC) using speckle tracking echocardiography (STE). METHODS: In this prospective study, the myocardial strain and dyssynchrony were analyzed using STE in a transversal four-chamber view in 180 fetuses (53 FDM, 127 FC) between 19 and 39 weeks of gestation. The measurements of the global and segmental longitudinal strain of both chambers (2C) and of the single left chamber (1C) were executed offline via QLab 10...
June 12, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29892477/bromocriptine-for-the-treatment-of-peripartum-cardiomyopathy
#12
REVIEW
Tobias Koenig, Johann Bauersachs, Denise Hilfiker-Kleiner
Peripartum cardiomyopathy (PPCM) is a life-threatening, pregnancy-associated heart disease that develops towards the end of pregnancy or in the first months following delivery in previously healthy women. Understanding of the pathophysiology has progressed in recent years, highlighting an oxidative-stress mediated cleavage of the nursing hormone prolactin into a toxic 16-kDa prolactin fragment as a major factor driving the disease. The 16-kDa prolactin fragment induces detrimental but potentially reversible effects on heart function...
May 2018: Cardiac Failure Review
https://www.readbyqxmd.com/read/29884601/the-rise-and-need-for-mobile-apps-for-maternal-and-child-health-care-in-china-survey-based-on-app-markets
#13
Puhong Zhang, Le Dong, Huan Chen, Yanling Chai, Jianbo Liu
BACKGROUND: Mobile health services are thriving in the field of maternal and child health in China due to expansions in the field of electronic health and the introduction of the two-child policy. There are numerous maternal and child health apps in computer stores, but the exact number of apps, number of downloads, and features of these apps is not known. OBJECTIVE: This study aimed to explore the use of maternal and child health apps in Android and iOS app stores and to describe the key functional features of the most popular apps, with the purpose of providing insight into further research and development of maternal and child health mobile health products...
June 8, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29880166/preeclampsia-eclampsia-and-future-cardiovascular-risk-among-women-in-taiwan
#14
Yu-Ling Kuo, Te-Fu Chan, Chien-Yi Wu, Chin-Ru Ker, Hung-Pin Tu
OBJECTIVE: This study aims to examine the long-term cardiovascular and cerebrovascular risks in a large cohort of women with past history of preeclampsia and/or eclampsia. MATERIALS AND METHODS: This is a retrospective longitudinal study using National Health Insurance Research Database from 1996 to 2010. We identified 1295 women with preeclampsia and eclampsia. The control group was 5180 pregnant women without preeclampsia/eclampsia, who were matched for age and date of delivery...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29876506/-will-she-live-a-long-happy-life-parents-concerns-for-their-children-with-fontan-circulation
#15
Karin du Plessis, Rebecca Peters, Ingrid King, Kirsty Robertson, Jonathan Mackley, Rachel Maree, Tracy Stanley, Louise Pickford, Brian Rose, Matthew Orchard, Helen Stewart, Yves d'Udekem
Background: Families of children at the worst end of the congenital heart disease endure a significant burden which is often not clearly delineated in the clinical literature. We examined the greatest concerns of parents whose children have a Fontan circulation. Methods: Parents ( N  = 107) of children in the Australian and New Zealand Fontan Registry completed online surveys with open-ended and closed questions. A qualitative method approach incorporating thematic analyses was used...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29873906/s3-guideline-for-the-treatment-of-psoriasis-vulgaris-update-short-version-part-2-special-patient-populations-and-treatment-situations
#16
Alexander Nast, Lasse Amelunxen, Matthias Augustin, Wolf-Henning Boehncke, Corinna Dressler, Matthew Gaskins, Peter Härle, Bernd Hoffstadt, Joachim Klaus, Joachim Koza, Ulrich Mrowietz, Hans-Michael Ockenfels, Sandra Philipp, Kristian Reich, Thomas Rosenbach, Berthold Rzany, Martin Schlaeger, Gerhard Schmid-Ott, Michael Sebastian, Ralph von Kiedrowski, Tobias Weberschock
The German guideline for the treatment of psoriasis vulgaris was updated using GRADE methodology. The guideline is based on a systematic literature review completed on December 1, 2016, and on a formal consensus and approval process. The second part of this short version of the guideline covers the following special patient populations and treatment situations: tuberculosis screening before and during psoriasis treatment, choice of psoriasis treatment for individuals wishing to have children, as well as during pregnancy and breast-feeding, and patients with joint involvement and vaccinations...
June 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29858105/cardiovascular-risk-profile-at-the-age-of-40-45-in-women-with-previous-hyperemesis-gravidarum-or-hypertensive-disorders-in-pregnancy-a-population-based-study
#17
Stine Fossum, Sigrun Halvorsen, Åse V Vikanes, Tessa J Roseboom, Inger Ariansen, Øyvind Næss
OBJECTIVE: To assess midlife cardiovascular risk profiles in women with a history of hyperemesis or hypertensive disorders in pregnancy compared to women with none of the studied pregnancy complications. STUDY DESIGN: Population-based study. Cardiovascular risk factors at the age of 40-45 among women with previous singleton births only were studied through linkage of the Norwegian Birth Registry and a Norwegian screening program (the Age 40 Program). MAIN OUTCOME MEASURES: Family history of coronary heart disease, body mass index, smoking, physical activity, systolic and diastolic blood pressure, heart rate, cholesterol, triglycerides, antihypertensive treatment and diabetes...
April 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29848951/trends-in-deaths-from-rheumatic-heart-disease-in-the-eastern-mediterranean-region-burden-and-challenges
#18
Azza M A M Abul-Fadl, Maha M Mourad, Alaa Ghamrawy, Ayah Ebada Sarhan
Rheumatic heart disease (RHD) is a preventable disease that is prevalent in developing regions of the world. Its eradication from most of the developed world indicates that this disease can be controlled and eliminated. Aim: To conduct an in-depth analysis of the trends and challenges of controlling RHD in the Eastern Mediterranean region (EMR). Methodology: Global data from the World Health Organization (WHO) data banks were retrieved for total deaths and age standardized death rate per 100,000 (ASDR) by age group, sex, and year (from 2000 to 2015)...
May 30, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29848449/biological-versus-mechanical-heart-valve-prosthesis-during-pregnancy-in-women-with-congenital-heart-disease
#19
Heleen Lameijer, Ymkje J van Slooten, Monique R M Jongbloed, Martijn A Oudijk, Marlies A M Kampman, Arie P van Dijk, Marco C Post, Barbara J Mulder, Krystyna M Sollie, Dirk J van Veldhuisen, Tjark Ebels, Joost P van Melle, Petronella G Pieper
BACKGROUND: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. METHODS: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. RESULTS: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P < ...
May 23, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29847165/perinatal-and-long-term-effects-of-maternal-uterine-artery-adenoviral-vegf-a-165-gene-therapy-in-the-growth-restricted-guinea-pig-fetus
#20
Owen Rhys Vaughan, Carlo A Rossi, Yuval Ginsberg, Anthony White, Mariya Hristova, Neil J Sebire, John Martin, Ian C Zachary, Donald M Peebles, Anna L David
Uterine artery application of adenoviral vascular endothelial growth factor gene therapy (Ad.VEGF-A165 ) increases uterine blood flow and fetal growth in experimental animals with fetal growth restriction (FGR). Whether Ad.VEGF-A165 reduces lifelong cardiovascular disease risk imposed by FGR remains unknown. Here, pregnant guinea pigs fed 70% normal food intake to induce FGR received Ad.VEGF-A165 (1x1010 viral particles, n=15) or vehicle (n=10), delivered to the external surface of the uterine arteries, in mid-pregnancy...
May 30, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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