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pregnancy and heart disease

Guilherme Ramires de Jesús, Savino Sciascia, Danieli Andrade, Iana Souza Nascimento, Renata Rosa, Medha Barbhaiya, Maria Tektonidou, Alessandra Banzato, Vittorio Pengo, Lanlan Ji, Pier Luigi Meroni, Amaia Ugarte, Hannah Cohen, D Ware Branch, Laura Andreoli, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Ricard Cervera, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Doruk Erkan, Roger A Levy
OBJECTIVE: To evaluate subsequent rate of thrombosis among obstetric antiphospholipid syndrome (Ob-APS) women in a multicenter database of antiphospholipid antibody (aPL)-positive patients; and clinical utility of adjusted Global Antiphospholipid Syndrome Score (aGAPSS), a validated tool to assess the likelihood of developing new thrombosis, in this group of patients. DESIGN: Retrospective study. SETTING: APS Alliance For Clinical Trials & International Networking (APS ACTION) Clinical Database And Repository...
September 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Birgit Linnemann
Antiphospholipid syndrome (APS) is an autoantibody-mediated acquired thrombophilia. It is characterized by the presence of antiphospholipid antibodies (APL) that are directed against phospholipid-binding plasma proteins, such as beta-2-glycoprotein I (b2GPI). Its main manifestations are recurrent vascular thromboses (so-called "thrombotic APS") and pregnancy complications ("obstetric APS"). According to the current consensus criteria, a persistently positive functional lupus anticoagulant (LA) assay and/or the presence of anti-b2GPI and/or anti-cardiolipin antibodies, together with clinical symptoms, is mandatory for the diagnosis of APS...
September 12, 2018: VASA. Zeitschrift Für Gefässkrankheiten
Jennifer J Stuart, Lauren J Tanz, Nancy R Cook, Donna Spiegelman, Stacey A Missmer, Eric B Rimm, Kathryn M Rexrode, Kenneth J Mukamal, Janet W Rich-Edwards
BACKGROUND: Hypertensive disorders of pregnancy (HDP) affect 10% to 15% of women and are associated with a 2-fold increased risk of cardiovascular disease (CVD). OBJECTIVES: This study sought to determine whether inclusion of HDP in an established CVD risk score improves prediction of CVD events in women. METHODS: The analysis comprised 106,230 ≤10-year observations contributed by 67,406 women, age ≥40 years, free of prior CVD, with data available on model covariates in the Nurses' Health Study II...
September 11, 2018: Journal of the American College of Cardiology
Fan Wu, Jianhong Zhou, Huan Zheng, Guanghui Liu
BACKGROUND: A growing body of literature has reported that a history of pre-eclampsia (PE) increases a woman's long-term risk of cardiovascular diseases (CVD). Autonomic nervous system dysfunction was found to be significant in this specific population, but most studies observed the role of sympathetic over-activation. The aim of this study was to assess whether parasympathetic impairment was involved in women 1 year after PE, and heart rate recovery (HRR) was used to represent parasympathetic tone...
July 2018: Pregnancy Hypertension
Michail M Padrul, Anna A Olina, Gulnara K Sadykova
Wilson-Konovalov's disease (DWK) is a polysyndrome hereditary disease associated with excessive accumulation of copper due to the delay in its removal from the body. The condition of the reproductive system in patients with DWK is not well understood. It is proved that copper is a microelement necessary for the synthesis of estrogens, the secretion of prostaglandins in the endometrium. According to the results of the study, in reproductive age patients with DWK who do not receive adequate therapy, the reproductive function is impaired...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Graeme N Smith, Jessica Pudwell, George R Saade
Cardiovascular disease (CVD) is the leading cause of death and disability among women, with more than half occurring in individuals with hypertension. New blood pressure criteria for the diagnosis of hypertension from the American College of Cardiology/American Heart Association recognize that there is no specific blood pressure threshold that is associated with vascular disease. We performed a secondary analysis of two published postpartum databases (the Pre-Eclampsia New Emerging Team [PE-NET] cohort and the Maternal Health Clinic [MHC] cohort) to determine the impact of the change in blood pressure criteria on the diagnosis of hypertension...
August 31, 2018: American Journal of Perinatology
Nadir Ahmed Ibrahim, Fathelrahman M Hassan, Mahmoud Mohamed Elgari, Sana Eltahir Abdalla
Aim: In this study, we aimed to analyze the genetic and acquired risk factors for deep vein thrombosis (DVT) of the lower extremities among Sudanese women. Methods: A total of 136 women were enrolled in the study, including 75 DVT patients and 61 healthy controls. Demographic and clinical data were collected using a specific questionnaire. Citrated blood samples of patients and controls were used for coagulation assays, and DNAs isolated from EDTA-blood samples were used for the detection of Factor V Leiden and prothrombin G20210A mutations using multiplex polymerase chain reaction-restriction fragment length polymorphism analysis...
2018: Vascular Health and Risk Management
Vera Regitz-Zagrosek
Biological sex (being female or male) significantly influences the course of disease. This simple fact must be considered in all cardiovascular diagnosis and therapy. However, major gaps in knowledge about and awareness of cardiovascular disease in women still impede the implementation of sex-specific strategies. Among the gaps are a lack of understanding of the pathophysiology of women-biased coronary artery disease syndromes (spasms, dissections, Takotsubo syndrome), sex differences in cardiomyopathies and heart failure, a higher prevalence of cardiomyopathies with sarcomeric mutations in men, a higher prevalence of heart failure with preserved ejection fraction in women, and sex-specific disease mechanisms, as well as sex differences in sudden cardiac arrest and long QT syndrome...
September 2018: Korean Circulation Journal
Shilpa Sharma, Malissa J Wood
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for one third of all deaths in 2015. Alarmingly, there has been slowing of the decline in age-standardized CVD mortality over the last 5 years compared to the previous 25 years. RECENT FINDINGS: Given the increasing global CVD burden, in 2011, the United Nations declared the goal to reduce premature mortality from the four main non-communicable diseases by 25% from 2010 to 2025, abbreviated as the 25 × 25 goal...
August 27, 2018: Current Treatment Options in Cardiovascular Medicine
Megan E B Clowse, Amanda M Eudy, Elizabeth Kiernan, Matthew R Williams, Bonnie Bermas, Eliza Chakravarty, Lisa R Sammaritano, Christina D Chambers, Jill Buyon
Objective: To survey an international sample of providers to determine their current practices for the prevention, screening, and treatment of congenital heart block (CHB) due to maternal Ro/SSA antibodies. Methods: A survey was designed by the organizing committee of the 9th International Conference of Reproduction, Pregnancy and Rheumatic Diseases. It was sent to attendants of the conference and authors of recent publications or abstracts at ACR 2012, 2013 or 2014 on rheumatic diseases and pregnancy...
July 1, 2018: Rheumatology
Lingling Wang, Xiaomei Xiang, Baibing Mi, Hui Song, Min Dong, Shuiping Zhang, Yuxue Bi, Yaling Zhao, Qiang Li, Qi Zhang, Li Zhang, Hong Yan, Duolao Wang, Shaonong Dang
Background: The aim of this study was to investigate an association between birth defects and exposure to sulfur dioxide (SO2), nitrogen dioxide (NO2) and particles ≤10 μm in an aerodynamic diameter (PM10) during early pregnancy in Xi'an, China. Methods: Birth defect data were from the Birth Defects Monitoring System of Xi'an, and data on ambient air pollutants during 2010-15 were from the Xi'an Environmental Protection Bureau. A generalized additive model (GAM) was used to investigate the relationship between birth defects and ambient air pollutants...
August 18, 2018: Journal of Public Health
Margarita Brida, Gerhard-Paul Diller, Heba Nashat, Maja Strozzi, Davor Milicic, Helmut Baumgartner, Michael A Gatzoulis
Congenital heart disease (CHD) is the most common inborn defect. Due to advances in paediatric care, surgical, and catheter procedures the number of adults with CHD has grown remarkably in recent years. Most of these patients, however, have residua from their original operation/s and require life-long care, many of them are subjected to further haemodynamic and electrophysiological interventions during adulthood. While such re-do surgical or catheter interventions together with device therapy and transplantation play a key therapeutic role, increasingly, adults with CHD require drug therapy for late complications namely heart failure (HF), arrhythmias, pulmonary and systemic hypertension, thromboembolic events, etc...
August 21, 2018: European Heart Journal
Shiyu Luo, Dahua Meng, Qifei Li, Xuehua Hu, Yuhua Chen, Chun He, Bobo Xie, Shangyang She, Yingfeng Li, Chunyun Fu
BACKGROUND: Congenital heart defects (CHD), as the most common congenital anomaly, have been reported to be associated with chromosomal abnormalities. Currently, patients with CHD are routinely offered karyotyping and chromosomal microarray (CMA) testing, but the genotype-phenotype relationship has not yet been fully established. OBJECTIVE: To determine the type and frequency of chromosomal abnormalities in fetuses with CHD and to analyze pregnancy outcomes of fetuses with heart abnormalities caused by different genetic factors...
August 20, 2018: Arquivos Brasileiros de Cardiologia
Jennifer A Courtney, James F Cnota, Helen N Jones
Congenital heart disease (CHD) is the most common birth defect, affecting ~1% of all live births (van der Linde et al., 2011). Despite improvements in clinical care, it is the leading cause of infant mortality related to birth defects (Yang et al., 2006) and burdens survivors with significant morbidity (Gilboa et al., 2016). Furthermore, CHD accounts for the largest proportion (26.7%) of birth defect-associated hospitalization costs-up to $6.1 billion in 2013 (Arth et al., 2017). Yet after decades of research with a primary focus on genetic etiology, the underlying cause of these defects remains unknown in the majority of cases (Zaidi and Brueckner, 2017)...
2018: Frontiers in Physiology
Leonard Mzee Ngunga, Gerald Yonga, Benjamin Wachira, Justin A Ezekowitz
BACKGROUND: Health care resource allocation remains challenging in lower middle income countries such as Kenya with meager resources being allocated to resuscitation and critical care. The causes and outcomes for in-hospital cardiac arrest and resuscitation have not been studied. OBJECTIVES: This study sought to determine the initial rhythm and the survival for patients developing in-hospital cardiac arrest. METHODS: This was a prospective study for in-hospital cardiac arrest in 6 Kenyan hospitals from July 2014 to April 2016...
August 18, 2018: Global Heart
Stephanie Brun, Emilie L'Ecuyer, Annie Dore, François-Pierre Mongeon, Aude-Christine Guedon, Line Leduc
RATIONALE: It is known that fetal growth is usually proportional to left-sided cardiac output (CO) which parallels the right-sided CO and that congenital right-sided lesions are usually associated with better perinatal outcomes than left-sided lesions. OBJECTIVE: Our objective was to document whether newborns from mothers with severe residual pulmonary valve insufficiency (PI) after surgical tetralogy of Fallot (TOF) or pulmonary stenosis (PS) correction have lower birth weight (BW) than newborns from mothers with absent, mild or moderate PI...
August 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
Hong-Yan Zhan, Feng-Qin Xu, Chuan-Xi Liu, Gang Zhao
BACKGROUND: In recent years, pulmonary artery blood flow acceleration time (AT) has been believed to be applicable in the examination of fetal lung development. OBJECTIVES: This study aims to evaluate the clinical significance of pulmonary artery blood flow AT as a parameter in monitoring of fetal pulmonary artery pressure. MATERIAL AND METHODS: A total of 31 fetuses in midor late-term pregnancy with tricuspid regurgitation were set as the study group (congenital heart disease with a tricuspid regurgitation pressure difference of more than 20 mm Hg was excluded)...
August 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Hong-Yu Duan, Kai-Yu Zhou, Tao Wang, Yi Zhang, Yi-Fei Li, Yi-Min Hua, Chuan Wang
Background: Valproic acid (VPA) exposure during pregnancy has been proven to contribute to congenital heart disease (CHD). Our previous findings implied that disruption of planar cell polarity (PCP) signaling pathway in cardiomyocytes might be a factor for the cardiac teratogenesis of VPA. In addition, the teratogenic ability of VPA is positively correlated to its histone deacetylase (HDAC) inhibition activity. This study aimed to investigate the effect of the VPA on cardiac morphogenesis, HDAC1/2/3, and PCP key genes (Vangl2/Scrib/Rac1), subsequently screening out the specific HDACs regulating PCP pathway...
September 5, 2018: Chinese Medical Journal
R De Vincenzo, L Tortorella, C Ricci, A F Cavaliere, G F Zannoni, M G Cefalo, G Scambia, A Fagotti
A case of stage IB2 cervical cancer at 27 weeks of pregnancy, treated with neoadjuvant chemotherapy followed by radical Cesarean hysterectomy with full pelvic and infra-mesenteric lymphadenectomy, and adjuvant chemo-radiation is described. While she remains without disease, her baby was diagnosed with acute myelogenous leukemia. We highlight the pre-operative work-up, treatment options, safety, feasibility, and outcomes for the mother and her fetus.
September 2018: Gynecologic Oncology
Kathleen Stergiopoulos, Fabio V Lima
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period. While the disease is relatively uncommon, its incidence is rising. It is a form of idiopathic dilated cardiomyopathy, defined as pregnancy-related left ventricular dysfunction, diagnosed either towards the end of pregnancy or in the months following delivery, in women without any other identifiable cause. The clinical presentation, diagnostic assessment and treatment usually mirror that of other forms of cardiomyopathy...
August 1, 2018: Trends in Cardiovascular Medicine
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