keyword
https://read.qxmd.com/read/38509492/clinical-characteristics-and-radiation-therapy-modality-of-younger-patients-with-early-stage-endometrial-cancer-a-multicenter-study-in-china-s-real-world
#21
JOURNAL ARTICLE
Kun Zhang, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengjv Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Ke Hu, Fuquan Zhang, Xiaorong Hou, Lichun Wei, Lijuan Zou
BACKGROUND: Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the clinical and pathological characteristics and adjuvant therapeutic modalities of both young and not -young patients with early-stage endometrial cancer in China's real world. METHODS: This retrospective study analyzed patients with early-stage endometrial cancer at 13 medical institutions in China from 1999 to 2015...
March 20, 2024: BMC Cancer
https://read.qxmd.com/read/38508588/analysis-of-risk-factors-for-post-operative-recurrence-or-progression-of-intravenous-leiomyomatosis
#22
JOURNAL ARTICLE
Guorui Zhang, Xin Yu, Jinghe Lang, Bao Liu, Dachun Zhao
OBJECTIVE: To analyse the risk factors for post-operative recurrence or progression of intravenous leiomyomatosis and explore the impact of different treatment strategies on patient prognosis. METHODS: Patients with intravenous leiomyomatosis who underwent surgery from January 2011 to December 2020 and who were followed for ≥3 months were included. The primary endpoint was recurrence (for patients with complete resection) or progression (for patients with incomplete resection)...
March 19, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38505737/video-rate-endocavity-photoacoustic-harmonic-ultrasound-imaging-with-miniaturized-light-delivery
#23
JOURNAL ARTICLE
Donghyeon Oh, Hyunhee Kim, Minsik Sung, Chulhong Kim
SIGNIFICANCE: Endocavity ultrasound (US) imaging is a frequently employed diagnostic technique in gynecology and urology for the assessment of male and female genital diseases that present challenges for conventional transabdominal imaging. The integration of photoacoustic (PA) imaging with clinical US imaging has displayed promising outcomes in clinical research. Nonetheless, its application has been constrained due to size limitations, restricting it to spatially confined locations such as vaginal or rectal canals...
January 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38500284/the-application-of-nanotechnological-therapeutic-platforms-against-gynecological-cancers
#24
JOURNAL ARTICLE
Vahideh Keyvani, Samaneh Mollazadeh, Espanta Riahi, Reihaneh Alsadat Mahmoudian, Masoomeh Tabari, Elmira Lagzian, Elnaz Ghorbani, Hamed Akbarzade, Amir-Sadra Gholami, Ibrahim Saeed Gataa, Seyed Mahdi Hassanian, Gordon A Ferns, Majid Khazaei, Amir Avan, Kazem Anvari
Gynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved bioavailability of various cargos...
March 18, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38497108/hormone-replacement-therapy-in-gynecological-cancer-survivors-and-brca-mutation-carriers-a-mito-group-survey
#25
JOURNAL ARTICLE
Innocenza Palaia, Giuseppe Caruso, Violante Di Donato, Camilla Turetta, Antonella Savarese, Giorgia Perniola, Roberta Gallo, Andrea Giannini, Vanda Salutari, Giorgio Bogani, Federica Tomao, Diana Giannarelli, Gabriella Gentile, Angela Musella, Ludovico Muzii, Sandro Pignata
OBJECTIVE: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT...
March 4, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38495486/the-analysis-of-cerna-networks-and-tumor-microenvironment-in-endometrial-cancer
#26
JOURNAL ARTICLE
Jian Huang, Xiaoyue Yang, Shen Xu, Ping Li
Background: Endometrial carcinoma is a life-threatening and aggressive tumor that affects women worldwide. ceRNAs and carcinoma-infiltrating immunocytes can be associated with tumor formation and progression. Therefore, investigating the unique mechanisms underlying endometrial carcinoma is crucial. Methods: Prognostic nomograms were constructed based on the differentially expressed genes between normal and tumor tissues. Twenty types of tumor immune infiltrating cells in uterine corpus endometrial carcinoma (UCEC) were examined using CIBERSORT...
2024: Journal of Cancer
https://read.qxmd.com/read/38494769/-net-survival-analysis-of-cancer-in-zhongshan-city-of-guangdong-province-in-china-1970-to-2014
#27
JOURNAL ARTICLE
Z M Li, Z H Liang, N Liu, K R Wei
Objective: To analyze survival data of cancer from 1970 to 2014 in Zhongshan City, Guangdong Province, and provide scientific basis for cancer prevention and control in Zhongshan City. Methods: The tumor incidence data of Zhongshan City, Guangdong Province from 1970 to 2014 were collected from Zhongshan Cancer Registry, and all patients were followed up to December 31, 2019. The standardized 5-year net survival rates and their annual percentage change (APC) and average annual percentage change (AAPC) for total and major cancers at different times were used to describe statistical analysis...
March 23, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38489270/protocol-for-identifying-metabolite-biomarkers-in-patient-uterine-fluid-for-early-ovarian-cancer-detection
#28
JOURNAL ARTICLE
Yuening Jiang, Wei Yue, Meiyu Bi, Yuhan Guo, Xiaoyang Gu, Mo Li
High mortality of ovarian cancer (OC) is primarily attributed to the lack of effective early detection methods. Uterine fluid, pooling molecules from neighboring ovaries, presents an organ-specific advantage over conventional blood samples. Here, we present a protocol for identifying metabolite biomarkers in uterine fluid for early OC detection. We describe steps for uterine fluid collection from patients, metabolite extraction, metabolomics experiments, and candidate metabolite biomarker screening. This standardized workflow holds the potential to achieve early OC diagnosis in clinical practice...
March 13, 2024: STAR protocols
https://read.qxmd.com/read/38488807/developing-novel-genomic-risk-stratification-models-in-soft-tissue-and-uterine-leiomyosarcoma
#29
JOURNAL ARTICLE
Josephine K Dermawan, Sarah Chiang, Samuel Singer, Bhumika Jadeja, Martee L Hensley, William D Tap, Sujana Movva, Robert G Maki, Cristina R Antonescu
PURPOSE: Leiomyosarcomas (LMS) are clinically and molecularly heterogeneous tumors. Despite genomic studies, current LMS risk stratification is not informed by molecular alterations. We propose a clinically applicable genomic risk stratification model. EXPERIMENTAL DESIGN: We performed comprehensive genomic profiling in a cohort of 195 soft tissue LMS (STLMS), 151 primary at presentation, and a control group of 238 uterine LMS (ULMS), 177 primary at presentation, with at least one-year follow up...
March 15, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38488586/the-role-and-challenges-of-regulating-endometrial-microbiome-in-uterine-health-and-diseases
#30
REVIEW
Chongshan Yuan, Kunyu Xie, Lianjun Feng, Shouyang Gao, Lifu Cai
The uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. The endometrial microbiome is highly susceptible to external factors such as age, hormones, menstrual, pregnancy, etc. When the microbiota is imbalanced, it will further promote the occurrence of uterine diseases such as endometritis and endometrial cancer. Regulating the microbiome of the endometrium is of positive significance for promoting uterine health...
March 15, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38487719/analysis-of-clinical-data-of-different-endometrial-pathological-types-in-perimenopausal-women-with-abnormal-uterine-bleeding
#31
JOURNAL ARTICLE
Li Wang, Shimin Quan, E Bai, Xiaofeng Yang
OBJECTIVE: Early detection and diagnosis are important for improving the therapeutic effect and quality of life in patients with endometrial cancer (EC). This study aimed to analyze the clinical data of different endometrial pathological types in perimenopausal women with abnormal uterine bleeding (AUB) in order to provide evidence for the prevention and early diagnosis of EC. METHODS: A total of 462 perimenopausal women with AUB were enrolled in this prospective observational study...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38486392/comprehensive-pan-cancer-analysis-of-cmpk2-as-biomarker-and-prognostic-indicator-for-immunotherapy
#32
JOURNAL ARTICLE
Jingyuan Luo, Qianyue Zhang, Shutong Wang, Luojie Zheng, Jie Liu, Yuchen Zhang, Yingchen Wang, Ranran Wang, Zhigang Xiao, Zheng Li
INTRODUCTION: UMP-CMP kinase 2 (CMPK2) is involved in mitochondrial DNA synthesis which can be oxidized and released into the cytoplasm in innate immunity. It initiates the assembly of NLRP3 inflammasomes and mediates various pathological processes such as human immunodeficiency virus infection and systemic lupus erythematosus. However the role of CMPK2 in tumor progression and tumor immunity remains unclear. METHOD: In this study we conducted a systematical analysis of CMPK2 across 33 different cancers based on datasets such as Genotype Tissue-Expression (GTEx) The Cancer Genome Atlas (TCGA) the Cancer Cell Line Encyclopedia (CCLE) and Tumor Immune Syngeneic Mouse (TISMO)...
March 13, 2024: Current Cancer Drug Targets
https://read.qxmd.com/read/38485187/cancer-oocyte-sas1b-protein-is-expressed-at-the-cell-surface-of-multiple-solid-tumors-and-targeted-with-antibody-drug-conjugates
#33
JOURNAL ARTICLE
Arabinda Mandal, Jagathpala Shetty, Christine A Tran, Walter C Olson, Mriganka Mandal, Bhupal Ban, Eusebio S Pires, Sara J Adair, Todd W Bauer, Craig L Slingluff, John C Herr
BACKGROUND: <u>S</u>perm <u>a</u>crosomal <u>S</u>LLP<u>1 b</u>inding (SAS1B) protein is found in oocytes, which is necessary for sperm-oocyte interaction, and also in uterine and pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth in these cancers. However, SAS1B expression in cancers and normal tissues has not been characterized. We hypothesized that SAS1B is expressed on the surface of other common solid cancer cells, but not on normal tissue cells, and might be selectively targeted therapeutically...
March 13, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38484948/3d-mr-elastography-based-stiffness-as-a-marker-for-predicting-tumor-grade-and-subtype-in-cervical-cancer
#34
JOURNAL ARTICLE
Yuanqiang Xiao, Wenying Chen, Xi Long, Mengsi Li, Lina Zhang, Chang Liu, Ying Deng, Chao Li, Bingjun He, Jun Chen, Jin Wang
BACKGROUND: Increasing evidence has indicated that high tissue stiffness (TS) may be a potential biomarker for evaluation of tumor aggressiveness. PURPOSE: To investigate the value of magnetic resonance elastography (MRE)-based quantitative parameters preoperatively predicting the tumor grade and subtype of cervical cancer (CC). STUDY TYPE: Retrospective. POPULATION: Twenty-five histopathology-proven CC patients and 7 healthy participants...
March 12, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38484247/treatment-of-cervical-cancer-complicated-by-advanced-pelvic-organ-prolapse-a-case-report
#35
JOURNAL ARTICLE
Hannah L Chapman, Jhalak J Dholakia, Samuel Marcrom, Maggie Liang, Holly E Richter
Concurrent cervical cancer with advanced pelvic organ prolapse is rare: there are no well-established treatment recommendations. It is hypothesized that chronic irritation, as with long-standing pelvic organ prolapse, may lead to dysplasia and human papillomavirus-independent carcinoma, which represents only 5% of cervical cancers. Two patients with complete uterine procidentia were referred to gynecologic oncology with cervical squamous cell carcinoma; both were clinically staged as International Federation of Gynaecology and Obstetrics IB3...
March 1, 2024: Urogynecology (Phila)
https://read.qxmd.com/read/38483012/the-immune-microenvironment-of-cancer-of-the-uterine-cervix
#36
REVIEW
Michail Mastrogeorgiou, Elena Chatzikalil, Stamatios Theocharis, Alexandra Papoudou-Bai, Michel Péoc'h, Mousa Mobarki, Georgia Karpathiou
While several treatment choices exist for cervical cancer, such as surgical therapy, chemotherapy, and radiotherapy, some patients will still show poor prognosis. HPV infection is a principal factor for cervical cancer development, from early inflammation to proliferation, angiogenesis, and neoplastic growth. While HPV T-cell responses exist, the tumor seems to evade the immune system upon its tolerance. The latter suggests the existence of a confluent tumor microenvironment responsible for the evasion tactics employed by the neoplasm...
March 1, 2024: Histology and Histopathology
https://read.qxmd.com/read/38481055/genomic-profile-analysis-of-leiomyomas-with-bizarre-nuclei-and-fumarate-hydratase-deficient-leiomyomas-strengths-weaknesses-and-limitations-of-array-cgh-interpretation
#37
JOURNAL ARTICLE
Quitterie Fontanges, Paul Dubos, Tom Lesluyes, Yec'han Laizet, Valérie Velasco, Bárbara Meléndez, Nicky D'Haene, Esther Oliva, Robert H Young, Laetitia Mayeur, Flora Rebier, Mélissa Alamé, Claire Larmonier, Mojgan Devouassoux-Shisheboran, Laurent Arnould, Isabelle Soubeyran, Camille Chakiba, Anne Floquet, Guillaume Babin, Frédéric Guyon, Eliane Mery, Sophie Le Guellec, Jean-Christophe Noël, Sabrina Croce, Frédéric Chibon
A close relationship has been demonstrated between genomic complexity and clinical outcome in uterine smooth muscle tumors. We studied the genomic profiles by array-CGH of 28 fumarate hydratase deficient leiomyomas and 37 leiomyomas with bizarre nuclei (LMBN) from 64 patients. Follow-up was available for 46 patients (from three to 249 months, mean 87.3 months). All patients were alive without evidence of disease. For 51 array-CGH interpretable tumors the mean Genomic Index (GI) was 16.4 (median: 9...
March 2024: Genes, Chromosomes & Cancer
https://read.qxmd.com/read/38480789/a-comprehensive-analysis-and-experimental-validation-of-tk1-in-uterine-corpus-endometrial-carcinoma
#38
JOURNAL ARTICLE
Yiqing Sun, Kaiwen Zhang, Tianqi Wang, Shuangshuang Zhao, Chao Gao, Fengxia Xue, Yingmei Wang
Uterine corpus endometrial carcinoma (UCEC) is becoming a main malignant cancer that threaten to women's health. Thymidine kinase 1 (TK1) is considering to be associated with tumorigenesis and development. Nevertheless, the function of TK1 in UCEC is still unclear. Herein, we analyzed the TK1 expression level in pan-cancer and found that TK1 was upregulated in a variety of cancers including UCEC. Patients of UCEC with high expression of TK1 were related to poor outcome. TK1 was also related to clinical stage, histologic grade and lymph node metastasis...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479874/-a-case-of-adenocarcinoma-hpv-independent-mesonephric-type-with-significant-response-to-neoadjuvant-chemotherapy
#39
JOURNAL ARTICLE
Katsunori Kuratsune, Taeko Ueda, Ryosuke Tajiri, Atsushi Tohyama, Kaori Hoshino, Hiroshi Harada, Tomoko Kurita, Chisachi Kubo, Kazuki Komatsu, Eisuke Shiba, Yusuke Matsuura, Kiyoshi Yoshino
Adenocarcinoma, HPV-independent, mesonephric type (hereafter referred to as "mesonephric carcinoma") arising from the cervix is rare, its treatment has not been established, and its sensitivity to chemotherapy has not been fully investigated. Here we report on a 30-year-old female patient who presented at our hospital with a chief complaint of abnormal genital bleeding. We suspected cervical cancer. Based on examination, biopsy, and imaging, she was diagnosed with stage IIA2 adenocarcinoma of the cervix and was scheduled for surgery...
2024: Journal of UOEH
https://read.qxmd.com/read/38479873/-reducing-the-time-before-the-console-in-robotic-assisted-laparoscopic-hysterectomy
#40
JOURNAL ARTICLE
Kaori Hoshino, Tomoko Kurita, Atsushi Tohyama, Yasuyuki Kinjo, Kazuaki Nishimura, Hiroshi Harada, Taeko Ueda, Seiji Kagami, Kiyoshi Yoshino, Yusuke Matsuura
Robotic-assisted surgery enables precise manipulations with magnified vision, stereoscopic vision, and forceps with multi-joint functions. It requires unique procedures such as position setting, port placement, roll-in, and docking, which lead to prolonged operation and anesthesia time. Five conditions described below were established at our institution to reduce the time to the initiation of console: (1) changing the patients' position from the flat lithotomy position to the spread legs position; (2) attaching a Hasson cone to hold the umbilical cannula stable; (3) changing the cannula's obturator (inner tube) from blunt to bladeless; (4) fixing the team, and (5) conducting regular docking training...
2024: Journal of UOEH
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