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HIV variation

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https://www.readbyqxmd.com/read/29777446/the-degree-of-hiv-1-amino-acid-variability-is-strictly-related-to-different-disease-progression-rates
#1
Rossana Scutari, Monica Faieta, Roberta D'Arrigo, Lavinia Fabeni, Cristina Mussini, Andrea Cossarizza, Claudio Casoli, Carlo Federico Perno, Valentina Svicher, Claudia Alteri, Stefano Aquaro
The aim of this study is to evaluate the amino acid variability of HIV-1 Gp41, C2-V3, and Nef in a group of patients characterized by different disease progression rates. HIV-1 sequences were collected from 19 Long term non progressor patients (LTNPs), 9 slow progressors (SPs), and 11 rapid progressors (RPs). Phylogenetic trees were estimated by MEGA 6. Differences in amino acid variability among sequences belonging to the 3 groups have been evaluated by amino acid divergence, Shannon entropy analysis, and the number of amino acid mutations (defined as amino acid variations compared with HxB2)...
May 17, 2018: Virus Genes
https://www.readbyqxmd.com/read/29775551/pharmacogenetic-associations-with-cytochrome-p450-in-antiretroviral-therapy-what-does-the-future-hold
#2
Gabriel Stillemans, Leila Belkhir, Dennis A Hesselink, Vincent Haufroid, Laure Elens
Several antiretroviral drugs used to treat infection with the Human Immunodeficiency Virus (HIV) are substrates of enzymes belonging to the cytochrome P450 (CYP) superfamily, which are polymorphically expressed. It may therefore be useful to take into account the genetic variation in these enzymes to predict the likelihood of anti-HIV treatment success, toxicity and the potential for drug-drug interactions. Areas covered: In this manuscript, the authors discuss the current state of knowledge regarding pharmacogenetic associations between CYP and all major antiretrovirals, as well as the importance of these associations...
May 18, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29775498/the-jarisch-herxheimer-reaction-in-syphilis-could-molecular-typing-help-to-understand-it-better
#3
M Arando, C Fernandez, M Mota-Foix, A Alvarez, P Armegol, M J Barberá, J Esperalba, M Vall-Mayans
OBJECTIVES: The Jarisch-Herxheimer reaction (JHR) is a febrile inflammatory reaction that may occur in patients after treatment of syphilis. The overall rate is estimated to be 10-25% with broad variations over time. It appears to be related to factors like stage of the disease or reagin titres. In this study we aimed to describe the incidence of and risk factors including strain typing for JHR among patients with syphilis. METHODS: From January through October 2015, 224 consecutive patients (82 of them with HIV) who were diagnosed with early syphilis were enrolled in this prospective observational study in a referral STI clinic in Barcelona...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29771801/detection-rate-of-high-grade-squamous-intraepithelial-lesions-as-a-quality-assurance-metric-for-high-resolution-anoscopy-in-hiv-positive-men
#4
Matthijs L Siegenbeek van Heukelom, Elske Marra, Irina Cairo, Arne Van Eeden, Maarten F Schim van der Loeff, Henry J C De Vries, Jan M Prins
BACKGROUND: High-resolution anoscopy-guided biopsies are the gold standard for identifying anal intraepithelial neoplasia, but diagnosing high-grade squamous intraepithelial lesions depends on the skills of the anoscopist. OBJECTIVE: This study aims to validate the high-grade squamous intraepithelial lesion detection rate as a quality assurance metric for high-resolution anoscopy in HIV-positive men. DESIGN: This is a retrospective study. SETTING: This study was conducted at 3 HIV outpatient clinics in Amsterdam, The Netherlands...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770078/evaluating-the-timeliness-of-reporting-in-a-first-nations-communicable-diseases-program
#5
A Lam, S Woods, N Ndubuka
Background: Timely reporting of communicable diseases is necessary to enable a prompt response to mitigate and control outbreaks. This is especially true among First Nations communities due to a number of factors, including unique social determinants of health, which can contribute to rapid disease transmission. Objective: To assess the timeliness of reporting for 12 notifiable communicable diseases in the Northern Inter-Tribal Health Authority, which includes 33 First Nations on-reserve communities in Northern Saskatchewan, Canada, and to assess whether there were differences in reporting times depending on degree of remoteness of community, season or year...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769530/comparison-of-the-genotypic-and-phenotypic-properties-of-hiv-1-standard-subtype-b-and-subtype-b-b-env-molecular-clones-derived-from-infections-in-china
#6
Hui Xie, Jianhui Nie, Qingqing Chen, Weijin Huang, Youchun Wang
Although a number of standardized human immunodeficiency virus 1 (HIV-1) pseudoviruses have been generated to assess neutralizing antibodies, subtype B/B' has not been comprehensively characterized either genotypically or phenotypically. Full-length env genes were isolated from plasma samples derived from B/B'-infected individuals, including former plasma donors and men who had sex with men. The neutralization properties of these pseudoviruses were determined by testing against sCD4, 16 neutralizing monoclonal antibodies and 44 plasma samples, including samples from those infected with the three major prevalent clades in China...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29769038/impact-of-new-daa-therapy-on-real-clinical-practice-a-multicenter-region-wide-cohort-study
#7
Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D'Offizi, Adriano Pellicelli, Orlando Armignacco, Francesco Saverio Mennini, Massimo Siciliano, Enrico Girardi, Vincenzo Panella, Giuseppe Ippolito
BACKGROUND: Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. METHODS: The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29757635/accurate-measurement-of-residual-dipolar-couplings-in-large-rnas-by-variable-flip-angle-nmr
#8
Jan Marchant, Ad Bax, Michael F Summers
NMR approaches using nucleotide-specific deuterium labeling schemes have enabled structural studies of biologically relevant RNAs of increasing size and complexity. Although local structure is well-determined using these methods, definition of global structural features, including relative orientations of independent helices, remains a challenge. Residual dipolar couplings, a potential source of orientation information, have not been obtainable for large RNAs due to poor sensitivity resulting from rapid heteronuclear signal decay...
May 14, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29753640/rates-of-prevalent-and-new-hiv-diagnoses-by-race-and-ethnicity-among-men-who-have-sex-with-men-u-s-states-2013-2014
#9
Eli S Rosenberg, David W Purcell, Jeremy A Grey, Abigail Hankin-Wei, Eric Hall, Patrick S Sullivan
PURPOSE: Men who have sex with men (MSM) bear a disproportionate burden of new and existing HIV infections in the United States, with black and Hispanic MSM facing the highest rates. A lack of data on MSM population sizes has precluded the understanding of state-level variations in these rates. METHODS: Using a recently developed model for estimating state-level population sizes of MSM by race that synthesizes data from the American Community Survey and the National Health and Nutrition Examination Survey, in conjunction with Centers for Disease Control and Prevention-based HIV diagnosis data, we estimated rates of living with an HIV diagnosis (2013) and new diagnosis among MSM (2014) by state and race...
April 30, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29751752/a-community-based-qualitative-study-on-the-experience-and-understandings-of-intimate-partner-violence-and-hiv-vulnerability-from-the-perspectives-of-female-sex-workers-and-male-intimate-partners-in-north-karnataka-state-india
#10
Andrea K Blanchard, Sapna G Nair, Sharon G Bruce, Satyanarayana Ramanaik, Raghavendra Thalinja, Srikanta Murthy, Prakash Javalkar, Priya Pillai, Martine Collumbien, Lori Heise, Shajy Isac, Parinita Bhattacharjee
BACKGROUND: Research has increasingly documented the important role that violence by clients and the police play in exacerbating HIV vulnerability for women in sex work. However few studies have examined violence in the intimate relationships of women in sex work, or drawn on community partnerships to explore the social dynamics involved. A community-based participatory research study was undertaken by community and academic partners leading intimate partner violence (IPV) and HIV prevention programs in Bagalkot district, Karnataka state, India...
May 11, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29749876/cd4-cell-count-variability-with-repeat-testing-in-south-africa-should-reporting-include-both-absolute-counts-and-ranges-of-plausible-values
#11
Willem Daniel Francois Venter, Matthew F Chersich, Mohammed Majam, Godspower Akpomiemie, Natasha Arulappan, Michelle Moorhouse, Nonkululeko Mashabane, Deborah K Glencross
Although eligibility for antiretroviral treatment is no longer based on CD4 thresholds, CD4 testing remains important. Variation in CD4 cell count complicates initiation of antibiotic prophylaxis, differential diagnoses and assessments of immunological recovery. Five hundred and fifty-three HIV-positive antiretroviral-naïve adults, recruited from inner-city clinics, had three serial CD4 cell count tests. Test 1 was mostly done in a laboratory network supporting primary care clinics, while Tests 2 and 3 were performed in a tertiary-level laboratory...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29745311/systemic-delays-in-the-initiation-of-antiretroviral-therapy-for-clinically-eligible-hiv-infected-patients-in-houston-texas-the-providers-report-card
#12
Osaro Mgbere, Maria Rodriguez-Barradas, Karen Joan Vigil, Melanie McNeese, Fazal Tabassam, Nadia Barahmani, Jason Wang, Raouf Arafat, Ekere James Essien
BACKGROUND: The current US HIV treatment guidelines support initiation of antiretroviral therapy (ART) for persons with HIV for personal health benefits and prevention of HIV transmission. However, high levels of adherence to ART are critical to maximize individual and public health benefits. We examined the nonclinical barriers to ART initiation for clinically eligible individuals and the provider- and patient-related factors associated with these barriers among HIV-infected patients in Houston/Harris County, Texas...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29742062/global-perspective-of-novel-therapeutic-strategies-for-the-management-of-neuroaids
#13
Swatantra Kumar, Vimal K Maurya, Himanshu R Dandu, Madan Lb Bhatt, Shailendra K Saxena
Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological complications. The neuropathology of neuroAIDS can be characterized by the presence of HIV infected macrophages and microglia in the brain, with the formation of multinucleated giant cells. Global predominant subtypes of HIV-1 clade B and C infections influence the differential effect of immune and neuronal dysfunctions, leading to clade-specific clinical variation in neuroAIDS patient cohorts...
May 8, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29737610/monitoring-the-hiv-continuum-of-care-in-key-populations-across-europe-and-central-asia
#14
A E Brown, K Attawell, D Hales, B D Rice, A Pharris, V Supervie, D Van Beckhoven, V C Delpech, M An der Heiden, U Marcus, M Maly, T Noori
OBJECTIVES: The aim of the study was to measure and compare national continuum of HIV care estimates in Europe and Central Asia in three key subpopulations: men who have sex with men (MSM), people who inject drugs (PWID) and migrants. METHODS: Responses to a 2016 European Centre for Disease Prevention and Control (ECDC) survey of 55 European and Central Asian countries were used to describe continuums of HIV care for the subpopulations. Data were analysed using three frameworks: Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets; breakpoint analysis identifying reductions between adjacent continuum stages; quadrant analysis categorizing countries using 90% cut-offs for continuum stages...
May 8, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29732896/weighing-the-evidence-of-efficacy-of-oral-prep-for-hiv-prevention-in-women-in-southern-africa
#15
Holly Janes, Lawrence Corey, Gita Ramjee, Lindsay N Carpp, Carl Lombard, Myron S Cohen, Peter B Gilbert, Glenda E Gray
As oral tenofovir-based regimens for pre-exposure prophylaxis (PrEP) are adopted as standard of care for HIV prevention, their utilization in clinical trials among women in southern Africa will require an accurate estimate of oral PrEP efficacy in this population. This information is critical for women in choosing this prevention strategy, and in public health policy making. Estimates of the efficacy of oral pre-exposure prophylaxis (PrEP) regimens containing tenofovir have varied widely across trials that enrolled women, with some studies reporting high efficacy and others reporting no efficacy...
May 6, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29732382/common-variation-in-nlrp3-is-associated-with-early-death-and-elevated-inflammasome-biomarkers-among-advanced-hiv-tb-co-infected-patients-in-botswana
#16
Shruthi Ravimohan, Kebatshabile Nfanyana, Neo Tamuhla, Caroline T Tiemessen, Drew Weissman, Gregory P Bisson
Background: Elevated inflammation is associated with early mortality among HIV/tuberculosis (TB) patients starting antiretroviral therapy (ART); however, the sources of immune activation are unclear. We hypothesized that common variation in innate immune genes contributes to excessive inflammation linked to death. As single nucleotide polymorphisms (SNPs) in inflammasome pathway genes can increase risk for inflammatory diseases, we investigated their association with early mortality among a previously described cohort of HIV/TB patients initiating ART in Botswana...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29718906/explaining-the-heterogeneity-in-average-costs-per-hiv-aids-patient-in-nigeria-the-role-of-supply-side-and-service-delivery-characteristics
#17
Sergio Bautista-Arredondo, M Arantxa Colchero, Ogbonna O Amanze, Gina La Hera-Fuentes, Omar Silverman-Retana, David Contreras-Loya, Gregory A Ashefor, Kayode M Ogungbemi
OBJECTIVE: We estimated the average annual cost per patient of ART per facility (unit cost) in Nigeria, described the variation in costs across facilities, and identified factors associated with this variation. METHODS: We used facility-level data of 80 facilities in Nigeria, collected between December 2014 and May 2015. We estimated unit costs at each facility as the ratio of total costs (the sum of costs of staff, recurrent inputs and services, capital, training, laboratory tests, and antiretroviral and TB treatment drugs) divided by the annual number of patients...
2018: PloS One
https://www.readbyqxmd.com/read/29708995/temporal-evolution-of-hiv-sero-discordancy-patterns-among-stable-couples-in-sub-saharan-africa
#18
Susanne F Awad, Hiam Chemaitelly, Laith J Abu-Raddad
INTRODUCTION: Objective was to examine the temporal variation of HIV sero-discordancy in select representative countries (Kenya, Lesotho, Mali, Niger, Tanzania, and Zimbabwe) in sub-Saharan Africa at different HIV epidemic scales. A sero-discordant couple is defined as a stable couple (SC) in which one partner is HIV-positive while the other is HIV-negative. METHODS: A deterministic compartmental mathematical model was constructed to describe HIV transmission dynamics...
2018: PloS One
https://www.readbyqxmd.com/read/29706352/whole-exome-sequencing-reveals-uncaptured-variation-and-distinct-ancestry-in-the-southern-african-population-of-botswana
#19
Gaone Retshabile, Busisiwe C Mlotshwa, Lesedi Williams, Savannah Mwesigwa, Gerald Mboowa, Zhuoyi Huang, Navin Rustagi, Shanker Swaminathan, Eric Katagirya, Samuel Kyobe, Misaki Wayengera, Grace P Kisitu, David P Kateete, Eddie M Wampande, Koketso Maplanka, Ishmael Kasvosve, Edward D Pettitt, Mogomotsi Matshaba, Betty Nsangi, Marape Marape, Masego Tsimako-Johnstone, Chester W Brown, Fuli Yu, Adeodata Kekitiinwa, Moses Joloba, Sununguko W Mpoloka, Graeme Mardon, Gabriel Anabwani, Neil A Hanchard
Large-scale, population-based genomic studies have provided a context for modern medical genetics. Among such studies, however, African populations have remained relatively underrepresented. The breadth of genetic diversity across the African continent argues for an exploration of local genomic context to facilitate burgeoning disease mapping studies in Africa. We sought to characterize genetic variation and to assess population substructure within a cohort of HIV-positive children from Botswana-a Southern African country that is regionally underrepresented in genomic databases...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29703941/couple-serostatus-patterns-in-sub-saharan-africa-illuminate-the-relative-roles-of-transmission-rates-and-sexual-network-characteristics-in-hiv-epidemiology
#20
Steven E Bellan, David Champredon, Jonathan Dushoff, Lauren Ancel Meyers
HIV prevalence has surpassed 30% in some African countries while peaking at less than 1% in others. The extent to which this variation is driven by biological factors influencing the HIV transmission rate or by variation in sexual network characteristics remains widely debated. Here, we leverage couple serostatus patterns to address this question. HIV prevalence is strongly correlated with couple serostatus patterns across the continent; in particular, high prevalence countries tend to have a lower ratio of serodiscordancy to concordant positivity...
April 27, 2018: Scientific Reports
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