keyword
MENU ▼
Read by QxMD icon Read
search

HIV variation

keyword
https://www.readbyqxmd.com/read/28530044/a-review-of-transition-experiences-in-perinatally-and-behaviourally-acquired-hiv-1-infection-same-same-but-different
#1
Phung Khanh Lam, Sarah Fidler, Caroline Foster
INTRODUCTION: Despite sharing common psychosocial and developmental experiences, adolescents living with perinatally and behaviourally acquired HIV-1 infection are different in terms of timing of HIV infection and developmental stage at infection. Therefore, it is of interest to identify similarities and differences between these two groups of adolescents living with HIV in their experiences, facilitators and barriers during the transition process. METHODS: A detailed literature search of peer-reviewed published papers was conducted on PubMed to identify relevant original research or viewpoints published up to September 2016...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28514276/sexual-network-drivers-of-hiv-and-herpes-simplex-virus-type-2-hsv-2-transmission-a-comparative-mathematical-modeling-analysis
#2
Ryosuke Omori, Laith J Abu-Raddad
OBJECTIVES: HIV and herpes simplex virus type 2 (HSV-2) infections are sexually transmitted and propagate in sexual networks. Using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which HSV-2 prevalence can be a proxy of HIV prevalence. DESIGN/METHODS: An individual-based simulation model was constructed to describe sex partnering and infection transmission, and was parameterized with representative natural history, transmission, and sexual behavior data...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28509569/hiv-1-crf07_bc-with-a-seven-amino-acid-deletion-in-the-gag-p6-region-dominates-in-hiv-1-infected-men-who-have-sex-with-men-in-china
#3
Yue Wu, Haiying Wang, Xuqi Ren, Zhengwei Wan, Guifang Hu, Shixing Tang
We examined sequence variation in the HIV-1 gag p6 region from 27 individuals infected with HIV-1 CRF07_BC. An additional 269 gag p6 sequences of CRF07_BC from the Los Alamos National Laboratory database were also analyzed. A unique deletion of seven amino acid (aa) (p6Δ7) (aa 30-36, PIDKELY, in the HXB2 genome) was observed to exist exclusively in CRF07_BC. Indeed, 54.1% (160/296) of the CRF07_BC sequences contained the p6Δ7 mutation. The prevalence of the p6Δ7 mutation was 37.2% (29/78) and 92.3% (48/52) in CRF07_BC-infected intravenous drug users and men who have sex with men (MSM), respectively...
May 16, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28505418/how-mutations-can-resist-drug-binding-yet-keep-hiv-1-protease-functional
#4
Rajeswari Appadurai, Sanjib Senapati
HIV-1 protease is an important drug target for AIDS therapy. Nearly ten small molecule drugs have been approved by FDA. However, prolonged usage of these drugs produced protease mutants that are insusceptible to many of these drugs. The mutated proteases however continue to cleave the substrate peptides and thus remain largely functional. This poses a major challenge in the treatment strategies. Thus it has become imperative to understand how these mutations induce drug resistance while maintaining the enzymatic activity of this protein...
May 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28502791/single-strand-consensus-sequencing-reveals-that-hiv-type-but-not-subtype-significantly-impacts-viral-mutation-frequencies-and-spectra
#5
Jonathan M O Rawson, Daryl M Gohl, Sean R Landman, Megan E Roth, Morgan E Meissner, Tara S Peterson, James S Hodges, Kenneth B Beckman, Louis M Mansky
A long-standing question of human immunodeficiency virus (HIV) genetic variation and evolution has been whether differences exist in mutation rate and/or mutation spectra among HIV types (i.e., HIV-1 versus HIV-2) as well as among HIV groups (i.e., HIV-1 groups M-P and HIV-2 groups A-H) and HIV-1 Group M subtypes (i.e., subtypes A-D, F-H, and J-K). To address this, a new single-strand consensus sequencing assay was developed for the determination of HIV mutation frequencies and spectra using the Illumina sequencing platform...
May 11, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28499138/human-pegivirus-1-in-the-csf-of-patients-with-hiv-associated-neurocognitive-disorder-hand-may-be-derived-from-blood-in-highly-viraemic-patients
#6
Diana Hardie, Heidi Smuts
BACKGROUND: Human pegivirus-1 (HPgV-1) infection in the brain has not been extensively examined and its association with disease remains unconfirmed. In a high throughput sequencing study to look for infectious agents that could play a role in HIV-associated neurocognitive disorder (HAND), this virus was detected in 3 of 8 CSF samples. OBJECTIVES: To determine the significance of this finding, additional patients were screened and the viral load and viral diversity in blood and CSF were examined...
April 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28497706/striking-ethnic-variations-in-the-epidemiology-of-chlamydia-trachomatis-in-haifa-district-israel-throughout-the-years-2001-2015
#7
Khalaf Kridin, Mogher Khamaisi, Shmuel Rishpon, Rami Grifat
Our objectives were to examine trends in the incidence of chlamydia over an extended period and compare the epidemiology of the infection between two distinct ethnic groups in Israel: Jews and Arabs. We examined the incidence rate of Chlamydia trachomatis infection among residents of Haifa District, northern Israel from 2001 to 2015, by reviewing archives of the Department of Epidemiology, Ministry of Health. Notified cases were stratified by age group, gender, and ethnic group. The overall incidence rate of Chlamydia was 10...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28494720/hla-c-single-nucleotide-polymorphism-associated-with-increased-viral-load-level-in-hiv-1-infected-individuals-from-northeast-brazil
#8
Ronaldo Celerino da Silva, Ronald Rodrigues de Moura, Antonio Victor Campos Coelho, Luiz Cláudio Arraes, Lucas André Cavalcanti Brandão, Sergio Crovella, Rafael Lima Guimarães
In our study we analyzed genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes, known to influence the HIV-1 replication and disease progression. We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321) and ZNRD1-AS1 (rs3869068), single nucleotide polymorphisms (SNPs) in 266 HIV-1-infected and 223 unexposed-uninfected individuals from Northeast Brazil. HLA-C SNPs were in Linkage Disequilibrium (D'=0.84), constituting four possible haplotypes...
May 11, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28484861/sex-life-satisfaction-in-sub-saharan-africa-a-descriptive-and-exploratory-analysis
#9
Stephen Cranney
Nearly all of the sex life satisfaction literature has dealt with developed-country settings, and nothing has been published on sex life satisfaction in sub-Saharan Africa. Not only is sub-Saharan African a substantively relevant area in its own right, but it also provides a useful point of comparison for patterns and relations found in developed-world contexts. A brief descriptive and exploratory study of sex life satisfaction in sub-Saharan Africa was conducted using the World Gallup Poll, a dataset with representative sex life satisfaction data for 31 countries and 25,483 cases...
May 8, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28484443/impact-of-genetic-variations-in-hiv-1-tat-on-ltr-mediated-transcription-via-tar-rna-interaction
#10
Larance Ronsard, Nilanjana Ganguli, Vivek K Singh, Kumaravel Mohankumar, Tripti Rai, Subhashree Sridharan, Sankar Pajaniradje, Binod Kumar, Devesh Rai, Suhnrita Chaudhuri, Mohane S Coumar, Vishnampettai G Ramachandran, Akhil C Banerjea
HIV-1 evades host defense through mutations and recombination events, generating numerous variants in an infected patient. These variants with an undiminished virulence can multiply rapidly in order to progress to AIDS. One of the targets to intervene in HIV-1 replication is the trans-activator of transcription (Tat), a major regulatory protein that transactivates the long terminal repeat promoter through its interaction with trans-activation response (TAR) RNA. In this study, HIV-1 infected patients (n = 120) from North India revealed Ser46Phe (20%) and Ser61Arg (2%) mutations in the Tat variants with a strong interaction toward TAR leading to enhanced transactivation activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28479971/reliability-validity-and-psychometric-properties-of-the-greek-translation-of-the-posttraumatic-stress-disorder-scale
#11
Konstantinos Kontoangelos, Sofia Tsiori, Garyfalia Poulakou, Konstantinos Protopapas, Ioannis Katsarolis, Vissaria Sakka, Dimitra Kavatha, Antonios Papadopoulos, Anastasia Antoniadou, Charalambos C Papageorgiou
The Greek version of the Davidson Trauma Scale (DTS) was developed to respond to the need of Greek-speaking individuals. The translated questionnaire was administered to 128 HIV outpatients (aged 37.1±9.1) and 166 control patients (aged 32.4±13.4). In addition to the DTS Greek scale, subjects were assessed with two other scales useful for assessing validity. For each factor analyses two components were extracted, based on Cattell's scree test. The two components solution accounted for 55.34% of the total variation in case of frequency variables and 61...
March 22, 2017: Mental Illness
https://www.readbyqxmd.com/read/28479111/co-utilization-of-a-tlr5-agonist-and-nano-formulation-of-hiv-1-vaccine-candidate-leads-to-increased-vaccine-immunogenicity-and-decreased-immunogenic-dose-a-preliminary-study
#12
Hajar Rostami, Masoumeh Ebtekar, Mehdi Shafiee Ardestani, Mohammad Hossein Yazdi, Mehdi Mahdavi
Vaccines currently available for AIDS show poor efficiency, demonstrating the need for new strategies to increase their immunogenicity. In this study, the HIV-1P24-Nef peptide was used as a model vaccine, followed by utilization of a novel strategy to increase its immunogenicity. There is a growing interest in using TLR agonists for vaccine formulations. Such molecules bind to their receptors on immune cells, especially the cell surface of antigen presenting cells, thereby activating these cells and inflammatory responses...
May 4, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28464889/highly-divergent-patterns-of-genetic-diversity-and-evolution-in-proviral-quasispecies-from-hiv-controllers
#13
Suwellen S D de Azevedo, Diogo Gama Caetano, Fernanda H Côrtes, Sylvia L M Teixeira, Karina Dos Santos Silva, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G Veloso, Mariza G Morgado, Gonzalo Bello
BACKGROUND: Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at the DNA proviral compartment in HIV controllers, however, has been more challenging and the precise correlation between the systemic viral suppression level and rate of reservoir's reseeding in those individuals is not fully understood. In this sense, we examined the proviral DNA quasispecies by single genome amplification of the env gene in a cohort of 23 HIV controllers from Brazil, divided in three groups, according to the level of systemic viral suppression: (1) elite controllers with persistent undetectable viral load (PEC, n = 6); (2) elite controllers with occasional episodes of transient (51-400 copies/mL) viremia (EEC, n = 7); and (3) viremic controllers with persistent low-level (80-2000 copies/mL) viremia (VC, n = 10)...
May 2, 2017: Retrovirology
https://www.readbyqxmd.com/read/28463709/multilevel-determinants-of-teenage-childbearing-in-sub-saharan-africa-in-the-context-of-hiv-aids
#14
Monica A Magadi
This paper examined national variations and multilevel determinants of teenage childbearing in sub-Saharan Africa (SSA) in the context of HIV/AIDS using data from recent Demographic and Health Surveys conducted in 29 countries of SSA. Results showed significant community and national variations in teenage childbearing, partly explained by socio-economic and HIV/AIDS context. At community level, lower HIV/AIDS stigma, higher wealth and female education were associated with lower teenage childbearing. However, national socio-economic status had an intricate relationship with teenage childbearing...
April 29, 2017: Health & Place
https://www.readbyqxmd.com/read/28458914/in-vivo-mutation-rates-and-the-landscape-of-fitness-costs-of-hiv-1
#15
Fabio Zanini, Vadim Puller, Johanna Brodin, Jan Albert, Richard A Neher
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we estimated mutation rates and fitness costs in HIV-1 from the dynamics of genetic variation. At approximately neutral sites, mutations accumulate with a rate of 1.2 × 10(-5) per site per day, in agreement with the rate measured in cell cultures. We estimated the rate from G to A to be the largest, followed by the other transitions C to T, T to C, and A to G, while transversions are less frequent...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28458735/features-of-maternal-hiv-1-associated-with-lack-of-vertical-transmission
#16
REVIEW
Nafees Ahmad, Aamir N Ahmad, Shahid N Ahmad
HIV-1 is transmitted from mother-to-child (vertical transmission) at an estimated rate of approximately 30% without any antiretroviral therapy (ART). However, administration of ART during pregnancy considerably diminishes the rate of mother-to-child transmission of HIV-1, which has become a standard of perinatal care in HIV-infected pregnant females in developed countries. Moreover, a majority of children born to HIV-infected mothers are uninfected without any ART. In addition, characteristics of HIV-1 and/or cellular factors in the mothers may play a role in influencing or preventing vertical transmission...
2017: Open Virology Journal
https://www.readbyqxmd.com/read/28456597/associations-of-giardia-lamblia-assemblages-with-hiv-infections-and-symptomatology-hiv-virus-and-assemblage-b-were-they-born-to-each-other
#17
Clarissa Perez Faria, Graziela Maria Zanini, Gisele Silva Dias, Maria do Céu Sousa
Giardia lamblia is an intestinal parasite that has an extensive genetic variation among isolates. This species is divided into eight different assemblages (A-H), but only assemblages A and B have been associated with human infections. Studies on the associations of G. lamblia assemblages and symptoms have been done but were inconclusive. The aim of this study was to correlate G. lamblia assemblages with symptoms in patients with and without HIV/AIDS and its association with the CD4T cell count. The cross-sectional survey was conducted among patients attending the Evandro Chagas National Institute of Infectious Diseases (INI/FIOCRUZ) in Rio de Janeiro from January 2011 to February 2015...
April 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28451269/enhancement-of-the-physicochemical-properties-of-pt-dien-nucleobase-2-for-hivncp7-targeting
#18
S D Tsotsoros, P B Lutz, A G Daniel, E J Peterson, R E F de Paiva, E Rivera, Y Qu, C A Bayse, N P Farrell
Physicochemical properties of coordination compounds can be exploited for molecular recognition of biomolecules. The inherent π-π stacking properties of [Pt(chelate)(N-donor)](2+) ([PtN4]) complexes were modulated by systematic variation of the chelate (diethylenetriamine and substituted derivatives) and N-donor (nucleobase or nucleoside) in the formally substitution-inert PtN4 coordination sphere. Approaches to target the HIV nucleocapsid protein HIVNCp7 are summarized building on (i) assessment of stacking interactions with simple tryptophan or tryptophan derivatives to (ii) the tryptophan-containing C-terminal zinc finger and (iii) to the full two-zinc finger peptide and its interactions with RNA and DNA...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28444057/determinant-factors-of-knowledge-attitudes-and-practices-regarding-std-aids-and-viral-hepatitis-among-youths-aged-18-to-29-years-in-brazil
#19
Miguel Barbosa Fontes, Rodrigo Campos Crivelaro, Alice Margini Scartezini, David Duarte Lima, Alexandre de Araújo Garcia, Rafael Tsuyoshi Fujioka
The scope of this study was to evaluate the vulnerability of Brazilian youths to STDs/HIV&AIDS and Viral Hepatitis. Interviews were conducted with 1,208 youths aged 18 to 29 in 15 states and the Federal District. The regional and national adjusted margin of error of the research was 2.8%. The study was approved by the School of Medicine of Brasilia University with support from PAHO and the Ministry of Health. A scale with 35 questions (knowledge, attitudes and practices) was the main dependent variable. Adjusted linear regression models identified the demographic and social determinant factors that explain scale variations...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28438553/human-leukocyte-antigen-class-i-a-b-and-c-allele-and-haplotype-variation-in-a-south-african-mixed-ancestry-population
#20
Shayne Loubser, Maria Paximadis, Caroline T Tiemessen
South Africa has a large (∼53million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼365years ago in the Western Cape region through interracial mixing of black Africans, Europeans and Asians. Admixed populations present unique opportunities to identify genetic factors involved in disease susceptibility...
April 21, 2017: Human Immunology
keyword
keyword
98394
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"