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https://www.readbyqxmd.com/read/29783261/epidemiology-of-acute-myocardial-infarction-in-ukraine-and-poltava-region
#1
Viacheslav M Zhdan, Grigory А Oksak, Oleh V Radomskyi, Denis I Shaposhnikov
OBJECTIVE: Introduction: The number of elderly people in society is increasing. Alike in all European countries, ageing population in Ukraine is observed, which affects the structure and dynamics of morbidity and mortality of the population towards the increase of chronic non-communicable diseases, which is the epidemic of the 21st century civilization. In 2010 in Ukraine, the proportion of people over the age of 60 was 20.6% of the total. The prevalence of all diseases among the elderly in 2010 amounted to 283522,8, and among the general population - 186746,4...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783235/-statistical-information-about-the-inflammatory-processes-of-the-jaw-facial-part-in-children
#2
Pavlo I Tkachenko, Serhii O Bilokon, Nataliia M Lokhmatova, Vitalina O Dobroskok, Olha B Dolenko, Nataliia M Korotych, Yuliia V Popelo
OBJECTIVE: Introduction: The acute and chronic inflammatory processes prevail in the structure of the dental surgical diseases in children. Notably, various forms of lymphadenitis, adenophlegmon and odontogenous osteomyelitis dominate in the specialized surgical units; however, it is not possible to resolve a number of organizational problems without clear understanding of the statistical situation. The aim: The paper is aimed at the analysis of the incidence rate of major nosological forms of the acute suppurative inflammations of the maxillofacial area in children for the prospective planning of arrangements to provide them with high-quality specialized care...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783224/influence-of-risk-factors-on-insulin-resistance-in-patients-with-overweight-and-obesity
#3
Tetiana Maksymets, Natalia Karpyshyn, Taras Gutor, Helen Sklyarova, Eugen Sklyarov
OBJECTIVE: Introduction: Obesity is a multifactorial, heterogenic disease, associated with an increased risk of morbidity and mortality due to cardiovascular diseases, diabetes, cancer, chronic liver and kidney diseases. Excessive body weight and obesity are serious medical and social problems, since their incidence is constantly increasing and has reached global epidemic proportions. The aim: Determining the influence of risk factors on insulin resistance level in patients with overweight and obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783208/the-role-of-hydrogen-sulfide-in-the-progression-mechanisms-of-non-alcoholic-steatohepatitis-and-chronic-kidney-disease
#4
Oksana S Khukhlina, Igor V Gerush, Alona A Antoniv, Olha Ye Mandryk, Tamara G Kopchuk, Svitlana P Melnychuk, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The steady increase in the incidence of non-alcoholic steatohepatitis (NASH) on the background of obesity and chronic kidney disease (CKD) in people of working age in Ukraine. The aim: To establish the role of hydrogen sulfide in the mechanisms of mutual burden and progression of non-alcoholic steatohepatitis and chronic kidney disease in patients with obesity. PATIENTS AND METHODS: Materials and methods: 114 patients with NASH were examined on the background of obesity of І-ІІ degree, including: 52 patients with NASH (group 1) (without accompanying CKD), 62 patients with NASH with a comorbid CKD І-ІІ degree (group 2)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783024/a-pooled-analysis-of-the-phase-3-revive-trials-randomized-double-blind-studies-to-evaluate-the-safety-and-efficacy-of-iclaprim-versus-vancomycin-for-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#5
David B Huang, G Ralph Corey, Thomas L Holland, Thomas Lodise, William O'Riordan, Mark H Wilcox, Thomas M File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres
BACKGROUND: Iclaprim, a diaminopyrimidine antibiotic, was compared with vancomycin for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in two studies (REVIVE-1 and REVIVE-2). OBJECTIVES: We explored the efficacy and tolerability of iclaprim in a pooled analysis of results from both studies. METHODS: REVIVE-1 and REVIVE-2 were Phase 3, double-blind, randomized (1:1), multicenter, active-controlled, non-inferiority (margin of 10%) trials, each designed to enroll 600 patients a piece with ABSSSI...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29783008/percutaneous-endoscopic-lumbar-discectomy-for-l5s1-lumbar-disc-herniation-via-transforaminal-approach-versus-interlaminar-approach-a-systematic-review-and-meta-analysis
#6
REVIEW
Jiageng Chen, Xiyue Jing, Changping Li, Yu Jiang, Sijin Cheng, Jun Ma
BACKGROUND: s: Several studies have compared the clinical efficacy of percutaneous endoscopic lumbar discectomy (PELD) for L5S1 lumbar disc herniation (LDH) via transforaminal approach and interlaminar approach, however, with contradictory results. The aim of this study was to explore the comparison of efficacy and safety between percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID) for L5S1 LDH. METHODS: Six common databases were comprehensively searched and relevant studies would be included into the analysis if it meet all the inclusion criteria...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29783003/non-malignant-sequelae-following-unconfined-power-morcellation-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#7
Hao M Zhang, Lee A Christianson, Claire L Templeman, Scott E Lentz
STUDY OBJECTIVE: To identify the incidence of repeat surgery and subsequent findings following the performance of unconfined uterine power morcellation. DESIGN: A retrospective descriptive study (Canadian Task Force II-2) SETTING: Southern California Kaiser Permanente Medical Centers PATIENTS: Women (n=5154) who underwent laparoscopic supra-cervical hysterectomy (LSH) with unconfined power morcellation. MEASUREMENTS AND MAIN RESULTS: Of the 5154 cases, 279 (5...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29782967/deficient-mitochondrial-biogenesis-in-il-2-activated-nk-cells-correlates-with-impaired-pgc1-%C3%AE-upregulation-in-elderly-humans
#8
Dante Miranda, Claudia Jara, Sophia Mejias, Viviana Ahumada, Marcelo Cortez-San Martin, Jorge Ibañez, Sandra Hirsch, Margarita Montoya
Immunosenescence has been described as age-associated changes in the immune function which are thought to be responsible for the increased morbidity with age. Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in immune defense against tumor and microbial diseases. Interestingly, aging-related NK cell dysfunction is associated with features of aging such as tumor incidence, reduced vaccination efficacy, and short survival due to infection. It is known that NK cell effector functions are critically dependent on cytokines and metabolic activity...
May 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29782951/clinical-consequences-of-toxic-envenomations-by-hymenoptera
#9
Justin O Schmidt
Many familiar Hymenoptera are brightly colored and can sting painfully-thus, their threat and clinical importance may be exaggerated. Most stinging insects only sting to defend themselves or their colonies from predators. The clinical nature of Hymenoptera envenomations contrasts that of other venomous animals, including other arthropods, primarily because allergic reaction, not direct intoxication, is the usual main concern. This review focuses mainly on the clinical features of direct toxicity to Hymenoptera envenomations, which can induce a high incidence of acute renal failure, liver failure, multiple organ failures, and death...
May 18, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29782922/dengue-chikungunya-and-zika-infections-imported-to-paris-between-2009-and-2016-characteristics-and-correlation-with-outbreaks-in-the-french-overseas-territories-of-guadeloupe-and-martinique
#10
Victor Vasquez, Elie Haddad, Alice Perignon, Stéphane Jaureguiberry, Ségolène Brichler, Isabelle Leparc-Goffart, Eric Caumes
BACKGROUND: Dengue (DV), chikungunya (CV) and Zika virus (ZV) infections are rapidly expanding across countries and diagnosed in returned travelers who represent epidemiological sentinels. French Territories of America (FTA) such as Guadeloupe and Martinique are highly touristic places and have experienced three consecutive outbreaks by such viruses in the last decade. OBJECTIVE: We evaluated how ill returned travelers could be deemed as epidemiological sentinels for these three expanding arboviral diseases during eight consecutive years...
May 18, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29782901/basal-cell-carcinoma-part-ii-contemporary-approaches-to-diagnosis-treatment-and-prevention
#11
REVIEW
Michael C Cameron, Erica Lee, Brian Hibler, Cerrene N Giordano, Christopher A Barker, Shoko Mori, Miguel Cordova, Kishwer S Nehal, Anthony M Rossi
As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. Part II of this series will present both standard of care and newly developed approaches to diagnosis, treatment, and prevention of this disease...
May 18, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29782900/basal-cell-carcinoma-part-1
#12
REVIEW
Michael C Cameron, Erica Lee, Brian Hibler, Christopher A Barker, Shoko Mori, Miguel Cordova, Kishwer S Nehal, Anthony M Rossi
As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. Part I of this series will describe our current understanding of this disease in regards to epidemiology, cost, clinical and histopathologic presentations, carcinogenesis, natural history, and disease associations...
May 18, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29782877/analysis-of-spontaneous-resolution-of-cytomegalovirus-replication-after-transplantation-in-cmv-seropositive-patients-with-pretransplant-cd8-ifng-response
#13
Aurora Páez-Vega, Antonio Poyato, Alberto Rodriguez-Benot, Lluis Guirado, Jesús Fortún, Oscar Len, Edson Abdala, María C Fariñas, Elisa Cordero, Carmen de Gracia, Domingo Hernández, Rafael González, Julián Torre-Cisneros, Sara Cantisán
This prospective study evaluates whether CMV-seropositive (R+) transplant patients with pretransplant CD8+IFNG+ T-cell response to cytomegalovirus (CMV) (CD8+IFNG+ response) can spontaneously clear the CMV viral load without requiring treatment. A total of 104 transplant patients (kidney/liver) with pretransplant CD8+IFNG+ response were evaluable. This response was determined using QuantiFERON-CMV assay. The incidence of CMV replication and disease was 45.2% (47/104) and 6.7% (7/104), respectively. Of the total patients, 77...
May 18, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29782642/tofacitinib-in-patients-with-moderate-to-severe-chronic-plaque-psoriasis-long-term-safety-and-efficacy-in-an-open-label-extension-study
#14
F Valenzuela, N J Korman, R Bissonnette, N Bakos, T-F Tsai, M K Harper, W C Ports, H Tan, A Tallman, H Valdez, A C Gardner
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor. Final safety and efficacy data from an open-label extension study of tofacitinib in psoriasis are reported. OBJECTIVE: To evaluate the long-term safety and durability of efficacy of tofacitinib in adults with moderate to severe chronic plaque psoriasis. METHODS: Eligible patients who completed qualifying Phase 2/3 tofacitinib studies received tofacitinib 10 mg twice daily (BID) until Month 3; subsequently, the dose could be adjusted by investigators to either 5 or 10 mg BID...
May 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29782618/liver-targeted-therapies-for-hepatocellular-carcinoma-prior-to-transplant-contemporary-management-strategies
#15
Mustafa Nazzal, Sameer Gadani, Abdullah Said, Mandy Rice, Obi Okoye, Ahmad Taha, Krista L Lentine
Hepatocellular carcinoma (HCC) is an aggressive neoplastic disease that has been rapidly increasing in incidence. It usually occurs in the background of liver disease, and cirrhosis. Definitive therapy requires surgical resection. However, in majority of cases surgical resection is not tolerated, especially in the presence of portal hypertension and cirrhosis. Orthotopic liver transplant (OLT) in well selected candidates has been accepted as a viable option. Due to a relative scarcity of donors compared to the number of listed recipients, long waiting times are anticipated...
April 2018: Glob Surg
https://www.readbyqxmd.com/read/29782526/decreased-risk-of-pneumonia-in-stroke-patients-receiving-acupuncture-a-nationwide-matched-pair-retrospective-cohort-study
#16
Chuen-Chau Chang, Ta-Liang Chen, Chao-Shun Lin, Chi-Li Chung, Chun-Chieh Yeh, Chaur-Jong Hu, Hsin-Long Lane, Chien-Chang Liao, Chun-Chuan Shih
BACKGROUND: Acupuncture treatment is common among stroke patients, but there is limited information available on whether acupuncture effectively prevents post-stroke pneumonia. The aim of this study was to analyze the differential risk of pneumonia after stroke between patients who did and did not receive acupuncture after discharge. METHODS: We used the Taiwan National Health Insurance Research Database to conduct a retrospective cohort study using propensity score matched-pairs of new stroke patients in 2000-2004 who did and did not receive acupuncture post-stroke...
2018: PloS One
https://www.readbyqxmd.com/read/29782486/clinical-socioeconomic-and-behavioural-factors-at-age-50-years-and-risk-of-cardiometabolic-multimorbidity-and-mortality-a-cohort-study
#17
Archana Singh-Manoux, Aurore Fayosse, Séverine Sabia, Adam Tabak, Martin Shipley, Aline Dugravot, Mika Kivimäki
BACKGROUND: Multimorbidity is increasingly common and is associated with adverse health outcomes, highlighting the need to broaden the single-disease framework that dominates medical research. We examined the role of midlife clinical characteristics, socioeconomic position, and behavioural factors in the development of cardiometabolic multimorbidity (at least 2 of diabetes, coronary heart disease, and stroke), along with how these factors modify risk of mortality. METHODS AND FINDINGS: Data on 8,270 men and women were drawn from the Whitehall II cohort study, with mean follow-up of 23...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29782482/trauma-patients-are-safe-to-fly-72-hours-after-tube-thoracostomy-removal
#18
David Zonies, Joel Elterman, Christopher Burns, Vincent Paul, John Oh, Jeremy Cannon
BACKGROUND: Current recommendations for safe air travel following traumatic pneumothorax are 2-3 weeks after radiographic resolution. These recommendations are based on several small observational studies and expert consensus which cite a theoretical risk of recurrence and hypoxia due to decreased oxygen tension at altitude. We sought to systematically study the timing of chest drain removal after traumatic pneumothorax and risk of recurrence in relation to air travel. METHODS: A retrospective cohort study of consecutively admitted patients who sustained a traumatic chest injury treated with tube thoracostomy over a 5-year period was undertaken...
May 18, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29782405/the-impact-of-anesthesia-influenced-process-measure-compliance-on-length-of-stay-results-from-an-enhanced-recovery-after-surgery-for-colorectal-surgery-cohort
#19
Michael C Grant, Claro M Pio Roda, Joseph K Canner, Philip Sommer, Daniel Galante, Deborah Hobson, Susan Gearhart, Christopher L Wu, Elizabeth Wick
BACKGROUND: Process measure compliance has been associated with improved outcomes in enhanced recovery after surgery (ERAS) programs. Herein, we sought to assess the impact of compliance with measures directly influenced by anesthesiology in an ERAS for colorectal surgery cohort. METHODS: From January 2013 to April 2015, data from 1140 consecutive patients were collected for all patients before (pre-ERAS) and after (ERAS) implementation of an ERAS program. Compliance with 9 specific process measures directly influenced by the anesthesiologist or acute pain service was analyzed to determine the impact on hospital length of stay (LOS)...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29782392/collagen-biomarkers-predict-new-onset-of-hypertension-in-normotensive-participants-the-multi-ethnic-study-of-atherosclerosis
#20
Daniel A Duprez, Myron D Gross, Joachim H Ix, Jorge R Kizer, Russell P Tracy, Steven Shea, David R Jacobs
OBJECTIVE: Vascular remodeling associated with increased extracellular matrix (ECM) may precede hypertension. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen turnover and are important in ECM remodeling. PIIINP and ICTP are increased in cardiovascular diseases (CVD). We hypothesized that PIIINP and ICTP among normotensives predict incident hypertension. METHODS: We included 1252 Multi-Ethnic Study of Atherosclerosis participants with mean age 58...
May 17, 2018: Journal of Hypertension
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