keyword
https://read.qxmd.com/read/38547158/management-of-hypertension-in-heart-transplant-recipients-an-ongoing-conundrum
#1
JOURNAL ARTICLE
Juan Duarte Torres, Selim R Krim
PURPOSE OF REVIEW: Hypertension remains one of the most common clinical problems leading to significant posttransplant complications. This study reviews the pathophysiology of hypertension in the postcardiac transplant phase and provides an update on currently available antihypertensive therapies for heart transplant patients. RECENT FINDINGS: The true prevalence of hypertension in the heart transplant population remains unknown. Effective blood pressure (BP) control is key to prevent left ventricular remodeling, diastolic dysfunction and stroke...
March 28, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38546964/chronic-obstructive-pulmonary-disease-in-heart-failure-challenges-in-diagnosis-and-treatment-for-hfpef-and-hfref
#2
REVIEW
Sergio Henrique Rodolpho Ramalho, André Luiz Pereira de Albuquerque
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is common in heart failure (HF), and it has a significant impact on the prognosis and quality of life of patients. Additionally, COPD is independently associated with lower adherence to first-line HF therapies. In this review, we outline the challenges of identifying and managing HF with preserved (HFpEF) and reduced (HFrEF) ejection fraction with coexisting COPD. RECENT FINDINGS: Spirometry is necessary for COPD diagnosis and prognosis but is underused in HF...
March 28, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38546846/unveiling-cardiac-involvement-in-juvenile-dermatomyositis-through-speckle-tracking-echocardiography
#3
JOURNAL ARTICLE
Reyhan Dedeoglu, Nujin Ulug Murt, Aybüke Gunalp, Yusuf İskender Cosgun, Funda Oztunc, Savas Dedeoglu, Amra Adrovic, Sezgin Sahin, Mehmet Yıldız, Kenan Barut, Esma Aslan, Elif Kılıc Konte, Ümit Gul, Ozgur Kasapcopur
Early detection of cardiac involvement in Juvenile Dermatomyositis (JDM) is difficult due to the absence of clinical signs and symptoms, with systolic dysfunction often emerging in late stages and associated with a poor prognosis. This study aimed to employ two-dimensional speckle-tracking echocardiography (STE) for subclinical assessment of left ventricular (LV) systolic failure in JDM and explore potential associations between impaired LV systolic function (LV-GLS) and disease activity. A prospective study enrolled 20 healthy volunteers and 26 JDM patients (< 18 years old) without cardiac symptoms...
March 28, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38546222/atrial-cardiomyocytes-contribute-to-the-inflammatory-status-associated-with-atrial-fibrillation-in-right-heart-disease
#4
JOURNAL ARTICLE
Ewen Le Quilliec, Charles-Alexandre LeBlanc, Orlane Neuilly, Jiening Xiao, Rim Younes, Yasemin Altuntas, Feng Xiong, Patrice Naud, Louis Villeneuve, Martin G Sirois, Jean-François Tanguay, Jean-Claude Tardif, Roddy Hiram
CONTEXT: Right heart disease (RHD), characterized by right ventricular (RV) and atrial (RA) hypertrophy, and cardiomyocytes' (CM) dysfunctions have been described to be associated with the incidence of atrial fibrillation (AF). RHD and AF have in common, an inflammatory status, but the mechanisms relating RHD, inflammation, and AF remain unclear. HYPOTHESES: RHD generates electrophysiological and morphological remodelling affecting the CM, leading to atrial inflammation and increased AF susceptibility...
March 28, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38545041/the-value-of-speckle-tracking-stratified-strain-combined-with-myocardial-work-measurement-in-evaluating-left-ventricular-function-in-patients-with-heart-failure-with-preserved-ejection-fraction
#5
JOURNAL ARTICLE
Jin Lan, Yan Wang, Rui Zhang, Jiacheng Li, Tianle Yu, Luyao Yin, Tingting Shao, Hongtao Lu, Chao Wang, Li Xue
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent progressive disease accompanied by poor quality of life, high utilization of medical resources, morbidity, and mortality. However, the role of left ventricular (LV) systolic dysfunction has yet to be well elaborated despite the preservation of the LV ejection fraction. This study aimed to explore the diagnostic value of speckle-tracking stratified strain combined with myocardial work (MW) measurement in evaluating LV systolic dysfunction in patients with HFpEF...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38542361/state-of-the-art-differentiation-protocols-for-patient-derived-cardiac-pacemaker-cells
#6
REVIEW
Eleonora Torre, Matteo E Mangoni, Alain Lacampagne, Albano C Meli, Pietro Mesirca
Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes raise the possibility of generating pluripotent stem cells from a wide range of human diseases. In the cardiology field, hiPSCs have been used to address the mechanistic bases of primary arrhythmias and in investigations of drug safety. These studies have been focused primarily on atrial and ventricular pathologies. Consequently, many hiPSC-based cardiac differentiation protocols have been developed to differentiate between atrial- or ventricular-like cardiomyocytes...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542302/treatment-with-rasburicase-in-hospitalized-patients-with-cardiorenal-syndrome-old-treatment-new-scenario
#7
JOURNAL ARTICLE
Rosa Melero, Beatriz Torroba-Sanz, Marian Goicoechea, Iago Sousa-Casasnovas, Jose María Barrio, Ana María García-Prieto, Patrocinio Rodriguez-Benitez, Xandra García-González, María Sanjurjo-Sáez
Cardiorenal syndrome (CRS) involves joint dysfunction of the heart and kidney. Acute forms share biochemical alterations like hyperuricaemia (HU) with tumour lysis syndrome (TLS). The mainstay treatment of acute CRS with systemic overload is diuretics, but rasburicase is used in TLS to prevent and treat hyperuricaemia. An observational, retrospective study was performed to assess the effectiveness and safety of a single dose of rasburicase in hospitalized patients with cardiorenal syndrome, worsening renal function and uric acid levels above 9 mg/dL...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542257/connexin43-a-promising-target-to-reduce-cardiac-arrhythmia-burden-in-pulmonary-arterial-hypertension
#8
REVIEW
Matus Sykora, Barbara Szeiffova Bacova, Katarina Andelova, Tamara Egan Benova, Adriana Martiskova, Lin-Hai Kurahara, Katsuya Hirano, Narcis Tribulova
While essential hypertension (HTN) is very prevalent, pulmonary arterial hypertension (PAH) is very rare in the general population. However, due to progressive heart failure, prognoses and survival rates are much worse in PAH. Patients with PAH are at a higher risk of developing supraventricular arrhythmias and malignant ventricular arrhythmias. The latter underlie sudden cardiac death regardless of the mechanical cardiac dysfunction. Systemic chronic inflammation and oxidative stress are causal factors that increase the risk of the occurrence of cardiac arrhythmias in hypertension...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541908/intravenous-landiolol-for-rate-control-in-supraventricular-tachyarrhythmias-in-patients-with-left-ventricular-dysfunction-a-systematic-review-and-meta-analysis
#9
REVIEW
Athina Nasoufidou, Andreas S Papazoglou, Panagiotis Stachteas, Efstratios Karagiannidis, Athanasios Samaras, Sophia Alexiou, Michail-Angelos Mourtzos, George Kassimis, Nikolaos Fragakis
Background: This systematic review explores the effects of landiolol administration in individuals presenting with supraventricular tachyarrhythmia (SVT) and concurrent left ventricular dysfunction, without being septic or in a peri-operative period. Methods: We systematically searched PubMed, Cochrane, Web of Science, and Scopus databases, retrieving a total of 15 eligible studies according to prespecified eligibility criteria. Results: Patients treated with landiolol experienced a substantial reduction in heart rate (HR) (mean HR reduction: 42 bpm, 95% confidence intervals (CIs): 37-47, I2 = 82%) and were more likely to achieve the target HR compared to those receiving alternative antiarrhythmic therapy (pooled odds ratio (OR): 5...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541835/right-ventricular-dysfunction-before-and-after-cardiac-surgery-prognostic-implications
#10
REVIEW
Anna Merlo, Camilla Cirelli, Enrico Vizzardi, Laura Fiorendi, Federica Roncali, Marco Marino, Maurizio Merlo, Michele Senni, Edoardo Sciatti
Right ventricular dysfunction is a prognostic factor for morbidity and mortality across a broad spectrum of cardiovascular diseases. While the role of the right ventricle in surgical patients has emerged, the prognostic impact of right ventricular dysfunction remains unclear in a large cardiac surgery population. We reviewed the existing literature about the role of right ventricular dysfunction in adults undergoing different kinds of cardiac surgery either present before or developed after surgery itself. Pre- and post-operative right ventricular dysfunction has demonstrated substantial prognostic implications...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541781/analysis-of-patients-with-severe-ards-on-vv-ecmo-treated-with-inhaled-no-a-retrospective-observational-study
#11
JOURNAL ARTICLE
Stefan Muenster, Jennifer Nadal, Jens-Christian Schewe, Heidi Ehrentraut, Stefan Kreyer, Christian Putensen, Stefan Felix Ehrentraut
(1) Background : This retrospective study focused on severe acute respiratory distress syndrome (ARDS) patients treated with veno-venous (VV) extracorporeal membrane oxygenation (ECMO) and who inhaled nitric oxide (NO) for pulmonary arterial hypertension (PAH) and/or right ventricular failure (RV failure). (2) Methods : Out of 662 ECMO-supported patients, 366 received VV ECMO, including 48 who inhaled NO. We examined the NO's indications, dosing, duration, and the ability to lower PAH. We compared patients with and without inhaled NO in terms of mechanical ventilation duration, ECMO weaning, organ dysfunction, in-hospital mortality, and survival...
March 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541723/cardio-oncoimmunology-cardiac-toxicity-cardiovascular-hypersensitivity-and-kounis-syndrome
#12
JOURNAL ARTICLE
Nicholas G Kounis, Ming-Yow Hung, Cesare de Gregorio, Virginia Mplani, Christos Gogos, Stelios F Assimakopoulos, Panagiotis Plotas, Periklis Dousdampanis, Sophia N Kouni, Anastasopoulou Maria, Grigorios Tsigkas, Ioanna Koniari
Cancer therapy can result in acute cardiac events, such as coronary artery spasm, acute myocardial infarction, thromboembolism, myocarditis, bradycardia, tachyarrhythmias, atrio-ventricular blocks, QT prolongation, torsades de pointes, pericardial effusion, and hypotension, as well as chronic conditions, such as hypertension, and systolic and diastolic left ventricular dysfunction presenting clinically as heart failure or cardiomyopathy. In cardio-oncology, when referring to cardiac toxicity and cardiovascular hypersensitivity, there is a great deal of misunderstanding...
March 18, 2024: Life
https://read.qxmd.com/read/38541678/vaers-vasculitis-adverse-events-retrospective-study-etiology-model-of-immune-complexes-activating-fc-receptors-in-kawasaki-disease-and-multisystem-inflammatory-syndromes
#13
JOURNAL ARTICLE
Darrell O Ricke, Nora Smith
BACKGROUND: Vasculitis diseases include Kawasaki disease (KD), Kawasaki disease shock syndrome (KDSS), Multisystem Inflammatory Syndrome (MIS), Henoch-Schönlein purpura (HS), or IgA vasculitis, and additional vasculitis diseases. These diseases are often preceded by infections or immunizations. Disease incidence rates are higher in children than in adults. These diseases have been extensively studied, but understanding of the disease etiology remains to be established. OBJECTIVE: Many studies have failed to demonstrate an association between vasculitis diseases and vaccination; this study examines possible associations...
March 7, 2024: Life
https://read.qxmd.com/read/38541655/time-to-recovery-from-systolic-dysfunction-correlates-with-left-ventricular-fibrosis-in-arrhythmia-induced-cardiomyopathy
#14
JOURNAL ARTICLE
Christian Schach, Daniel Lavall, Nicola Voßhage, Thomas Körtl, Christine Meindl, Ekrem Ücer, Okka Hamer, Lars S Maier, Rolf Wachter, Samuel Sossalla
BACKGROUND: Arrhythmia-induced cardiomyopathy (AIC) is characterized by the reversibility of left ventricular (LV) systolic dysfunction (LVSD) after rhythm restoration. This study is a cardiac magnetic resonance tomography substudy of our AIC trial with the purpose to investigate whether left ventricular fibrosis affects the time to recovery (TTR) in patients with AIC. METHOD: Patients with newly diagnosed and otherwise unexplainable LVSD and tachyarrhythmia were prospectively recruited...
March 1, 2024: Life
https://read.qxmd.com/read/38541121/effects-of-liraglutide-empagliflozin-and-their-combination-on-left-atrial-strain-and-arterial-function
#15
RANDOMIZED CONTROLLED TRIAL
Konstantinos Katogiannis, John Thymis, Foteini Kousathana, George Pavlidis, Emmanouil Korakas, Aikaterini Kountouri, Konstantinos Balampanis, Vasiliki Prentza, Gavriella Kostelli, Helen Michalopoulou, Damianos Tsilivarakis, Vaia Lambadiari, Ignatios Ikonomidis
Background and Objectives : Glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are cardioprotective drugs. We investigated their effects on left atrial function, a major determinant of cardiac diastolic dysfunction in type 2 diabetes mellitus. We also explored the association of changes in arterial stiffness with those of the LA strain after treatment. Materials and Methods : A total of 200 patients (59.5 ± 9.1 year old, 151 male) with type 2 diabetes mellitus treated with metformin were randomized to insulin (n = 50 served as controls), liraglutide (n = 50), empagliflozin (n = 50) or their combination (liraglutide + empagliflozin) (n = 50)...
February 26, 2024: Medicina
https://read.qxmd.com/read/38540440/novel-myh7-variant-in-the-neonate-of-a-mother-with-gestational-diabetes-mellitus-showing-left-ventricular-hypertrophy-and-noncompaction
#16
Sayaka W Ozawa, Satomi Inomata, Yukiko Hata, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Naoki Nishida, Fukiko Ichida, Keiichi Hirono
BACKGROUND: Left ventricular hypertrophy (LVH) is a well-recognized cardiac dysfunction in infants of mothers with gestational diabetes mellitus (GDM). Left ventricular noncompaction (LVNC) is a cardiomyopathy that is morphologically characterized by numerous prominent trabeculations and deep intertrabecular recesses on cardiovascular imaging. However, there have been no case reports on neonates of mothers with GDM showing LVH and LVNC. CASE PRESENTATION: A patient, with LVH of a mother with GDM, was delivered at 36 weeks of gestation...
March 20, 2024: Genes
https://read.qxmd.com/read/38540180/thyroid-dysfunction-in-advanced-heart-failure-patients-and-its-correlation-with-amiodarone-therapy-a-two-year-study
#17
JOURNAL ARTICLE
Agnieszka Kuczaj, Szymon Warwas, Anna Danel, Piotr Przybyłowski, Tomasz Hrapkowicz
(1) Background: Advanced heart failure often accompanies ventricular arrhythmias, necessitating antiarrhythmic therapies. Amiodarone, commonly used for this purpose, may induce thyroid dysfunction due to its high iodine content. However, the prevalence and correlation of thyroid dysfunction with amiodarone in end-stage heart failure patients remain unclear. Aim: This study aimed to evaluate the prevalence and types of thyroid dysfunction and their association with amiodarone among 200 patients diagnosed with advanced heart failure eligible for transplantation...
March 3, 2024: Biomedicines
https://read.qxmd.com/read/38540088/hemodialysis-efficiency-predictor-in-end-stage-kidney-disease-using-real-time-heart-rate-variability
#18
JOURNAL ARTICLE
Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, Yeonsoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin
BACKGROUND: Autonomic dysfunction as a long-term complication may occur in end-stage kidney disease (ESKD) patients and can be diagnosed using heart rate variability (HRV) analyzed from electrocardiogram (ECG) recordings. There is limited data about HRV using real-time ECG to predict hemodialysis (HD) efficiency in patients with ESKD who are routinely doing HD in the real world. METHODS: A total of 50 patients (62.1 ± 10.7 years) with ESKD underwent continuous real-time ECG monitoring (237...
February 20, 2024: Biomedicines
https://read.qxmd.com/read/38539818/alterations-in-mitochondrial-oxidative-phosphorylation-system-relationship-of-complex-v-and-cardiac-dysfunction-in-human-heart-failure
#19
JOURNAL ARTICLE
Isaac Giménez-Escamilla, Carlota Benedicto, Lorena Pérez-Carrillo, Marta Delgado-Arija, Irene González-Torrent, Roger Vilchez, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Heart failure (HF) is a disease related to bioenergetic mitochondrial abnormalities. However, the whole status of molecules involved in the oxidative phosphorylation system (OXPHOS) is unknown. Therefore, we analyzed the OXPHOS transcriptome of human cardiac tissue by RNA-seq analyses (mRNA n = 36; ncRNA n = 30) in HF patients (ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM)) and control subjects. We detected 28 altered genes in these patients, highlighting greater deregulation in ICM. Specifically, we found a general overexpression of complex V (ATP synthase) elements, among them, ATP5I (ICM, FC = 2...
February 26, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38538806/utility-of-the-venous-excess-ultrasound-vexus-score-to-track-dynamic-change-in-volume-status-in-patients-undergoing-fluid-removal-during-haemodialysis-the-acuvex-study
#20
JOURNAL ARTICLE
Adrian Wong, Olusegun Olusanya, Jim Watchorn, Kate Bramham, Sam Hutchings
BACKGROUND: The use of ultrasound assessment, including the Venous Excess Ultrasound (VEXUS) score, is increasingly being utilised as part of fluid status assessment in clinical practice. We aimed to evaluate the ability of the VEXUS score to track fluid removal during the course of the dialysis session and explore the relationship between traditional measures of fluid status and venous congestion. METHODS: Single-centre, observational study in patients undergoing intermittent haemodialysis, who presented above their target dry weight...
March 27, 2024: The ultrasound journal
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