keyword
https://read.qxmd.com/read/38492720/choice-of-revascularization-strategy-for-ischemic-cardiomyopathy-due-to-multi-vessel-coronary-disease
#1
JOURNAL ARTICLE
Anas H Alzahrani, Shinobu Itagaki, Natalia Egorova, Joanna Chikwe
BACKGROUND: Limited comparative data guide the decision between coronary bypass surgery (CABG) versus percutaneous coronary intervention (PCI) for multivessel revascularization in ischemic cardiomyopathy. OBJECTIVES: To compare long-term outcomes of CABG and PCI for ischemic cardiomyopathy. METHODS: Clinical registries from NJ Department of Health linked to administrative databases were used to compare all-cause mortality, repeat revascularization, heart failure (HF) readmissions, myocardial infarction (MI), and stroke using Cox proportional hazards and propensity matching with competing risk analysis in 5988 patients with ejection fraction ≤35% who underwent CABG (3673,61...
March 14, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38491741/obesity-the-perfect-storm-for-heart-failure
#2
REVIEW
Maria Lembo, Teresa Strisciuglio, Celeste Fonderico, Costantino Mancusi, Raffaele Izzo, Valentina Trimarco, Alessandro Bellis, Emanuele Barbato, Giovanni Esposito, Carmine Morisco, Speranza Rubattu
Obesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association between obesity and HF including left ventricular remodelling and epicardial fat accumulation, endothelial dysfunction, and coronary microvascular dysfunction...
March 15, 2024: ESC Heart Failure
https://read.qxmd.com/read/38491532/trastuzumab-in-patients-with-breast-cancer-and-pre-existing-left-ventricular-systolic-dysfunction
#3
JOURNAL ARTICLE
Azin Alizadehasl, Mina Mohseni, Kamran Roudini, Parisa Firoozbakhsh
BACKGROUND: Trastuzumab is one of the most effective treatments in HER-2 positive breast cancer patients. However, it is associated with development of cardiomyopathy/heart failure (HF) which is often a limiting side effect and associated with overall adverse outcomes. As a result, patients with pre-existing LV systolic dysfunction (LVSD) are often excluded from receiving anti-HER-2 therapy, which may lead to less effective cancer treatment and worse prognosis. OBJECTIVES: The current study aims to evaluate the safety of trastuzumab in patients with HER-2 positive breast cancer and pre-existing LVSD...
March 15, 2024: Cardio-Oncology
https://read.qxmd.com/read/38491142/prognostic-impact-and-predictors-of-persistent-renal-dysfunction-in-acute-kidney-injury-after-percutaneous-coronary-intervention-for-acute-myocardial-infarction
#4
JOURNAL ARTICLE
Takuya Nakamura, Makoto Watanabe, Junichi Sugiura, Atsushi Kyodo, Saki Nobuta, Kazutaka Nogi, Yasuki Nakada, Satomi Ishihara, Yukihiro Hashimoto, Hitoshi Nakagawa, Tomoya Ueda, Ayako Seno, Taku Nishida, Kenji Onoue, Shungo Hikoso
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or ≥ 50% from baseline within 48 h after PCI. Persistent AKI was defined as residual impairment of SCr ≥ 0...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490601/beyond-conduction-impairment-unveiling-the-profound-myocardial-injury-in-left-bundle-branch-block
#5
JOURNAL ARTICLE
Xiaoxian Wang, Beibei Ge, Changqing Miao, Christopher Lee, Jorge E Romero, Peng Li, Fang Wang, Di Xu, Minglong Chen, Dianfu Li, Dong Li, Mingxia Li, Fang Xu, Yan Li, Chanjuan Gong, Cynthia C Taub, Jing Yao
BACKGROUND: Left bundle branch block (LBBB) represents a frequently encountered conduction system disorder. Despite its widespread occurrence, a continual dilemma persists regarding its intricate association with underlying cardiomyopathy and its pivotal role in the initiation of dilated cardiomyopathy. The pathological alterations linked to LBBB-induced cardiomyopathy (LBBB-CM) have remained elusive. OBJECTIVE: This study sought to investigate the chronologic dynamics of LBBB to left ventricular dysfunction and pathological mechanism of LBBB-CM...
March 13, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38490272/cobalt-protoporphyrin-promotes-heme-oxygenase-1-expression-and-ameliorates-cardiac-dysfunction-in-long-term-fasting-mice
#6
JOURNAL ARTICLE
Masayuki Shiba, Takao Kato, Yuta Seko, Eri Minamino-Muta, Yohei Tanada, Takeshi Kimura, Koh Ono
BACKGROUND: The association between malnutrition and cardiac dysfunction has been reported. Heme oxygenase (HO)-1 played protective roles in the animals functioning as a myocardial infarction, heart failure, or cardiomyopathy model. We hypothesized that the administration of HO-1 inducer, cobalt protoporphyrin (CoPP) reduces oxidative stress and ameliorates cardiac systolic dysfunction in long-term fasting mice. METHODS: C57BL/6 J mice were classified into three groups: fed mice (fed group), 48-h fasting mice with a single intraperitoneal injection of the corresponding vehicle (fasting group), and 48-h fasting mice with a single intraperitoneal injection of 5 mg/kg CoPP (CoPP group)...
March 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38489788/sex-specific-effects-of-frailty-on-cardiac-structure-and-function-insights-from-preclinical-models
#7
JOURNAL ARTICLE
Elise S Bisset, Susan E Howlett
Advanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a major risk factor for cardiovascular disease and predicts adverse outcomes in those affected...
March 15, 2024: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/38488960/correlation-of-the-left-ventricular-systolic-dysfunction-and-ventricular-depolarization-in-a-post-infarction-model-of-chronic-heart-failure
#8
JOURNAL ARTICLE
I M Roshchevskaya, O V Suslonova, S L Smirnova, E O Ionova, M B Vititnova, I B Tsorin, S A Kryzhanovskii
The body surface potential mapping of the heart during the period of ventricular depolarization and the inotropic function of the ventricles were studied in rats under conditions of a translational model of post-infarction chronic heart failure developed by us. We revealed a statistically significant (p<0.001) correlation between the left-ventricular ejection fraction and the values of the maximum positive and negative extrema of the cardioelectric field on the body surface of rats with post-infarction chronic heart failure caused by anterior transmural myocardial infarction...
March 15, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38488337/optimal-combination-of-right-ventricular-functional-parameters-using-echocardiography-in-pulmonary-arterial-hypertension
#9
JOURNAL ARTICLE
Qimou Li, Yu Zhang, Xiaopei Cui, Weida Lu, Qiushang Ji, Mei Zhang
AIMS: Novel echocardiographic parameters of right ventricular (RV) function, including speckle-tracking-derived, three-dimensional, and RV-pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertension (PAH). The relative role of these parameters in the risk stratification of PAH patients is unclear. We compared the performance of multiple RV parameters and sought to establish an optimal model for identifying the risk profile of patients with PAH...
March 15, 2024: ESC Heart Failure
https://read.qxmd.com/read/38487879/small-extracellular-vesicles-from-infarcted-and-failing-heart-accelerate-tumor-growth
#10
JOURNAL ARTICLE
Tal Caller, Itai Rotem, Olga Shaihov-Teper, Daria Lendengolts, Yeshai Schary, Ruty Shai, Efrat Glick-Saar, Dan Dominissini, Menachem Motiei, Idan Katzir, Rachela Popovtzer, Merav Nahmoud, Alex Boomgarden, Crislyn D'Souza-Schorey, Nili Naftali-Shani, Jonathan Leor
BACKGROUND: Myocardial infarction (MI) and heart failure are associated with an increased incidence of cancer. However, the mechanism is complex and unclear. Here, we aimed to test our hypothesis that cardiac small extracellular vesicles (sEVs), particularly cardiac mesenchymal stromal cell-derived sEVs (cMSC-sEVs), contribute to the link between post-MI left ventricular dysfunction (LVD) and cancer. METHODS: We purified and characterized sEVs from post-MI hearts and cultured cMSCs...
March 15, 2024: Circulation
https://read.qxmd.com/read/38487870/left-atrial-shape-as-a-marker-of-atrial-myopathy-in-embolic-stroke-of-undetermined-source
#11
JOURNAL ARTICLE
Aaisha Ferkh, Kasun De Silva, Jennifer Pham, Luke Stefani, Karen Byth, Amy Clark, Siddharth J Trivedi, Sai Nagaratnam, Andrew Duggins, Eddy Kizana, Aravinda Thiagalingam, Liza Thomas
AIMS: Embolic Stroke of Undetermined Source (ESUS) results in significant morbidity. A left atrial (LA) myopathy is implicated in a proportion of these patients. We hypothesized that LA shape varies by cause of stroke (cardioembolic versus ESUS). METHODS AND RESULTS: 236 ischemic stroke, atrial fibrillation (AF) patients and controls were recruited prospectively. AF was classified as paroxysmal (PAF) or persistent AF (PersAF). Stroke patients comprised cardioembolic stroke (CE) secondary to AF and ESUS...
March 15, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38486376/recombinant-human-soluble-domain-of-cd39l3-and-ticagrelor-cardioprotective-effects-in-experimental-myocardial-infarction
#12
JOURNAL ARTICLE
Gemma Vilahur, Monika Radike, Pablo Sutelman, Soumaya Ben-Aicha, Manuel Gutiérrez, Laura Casaní, Daniel Hovdal, Emily L Ongstad, Anders Gabrielsen, Alberto Hidalgo, Ola Fjellström, Leif Carlsson, Lina Badimon
BACKGROUND AND AIMS: The ecto-nucleoside triphosphate diphosphohydrolases of the CD39 family degrade ATP and ADP into AMP, which is converted into adenosine by the extracellular CD73/ecto-5-nucleotidase. This pathway has been explored in antithrombotic treatments but little in myocardial protection. We have investigated whether the administration of solCD39L3 (AZD3366) confers additional cardioprotection to that of ticagrelor alone in a pre-clinical model of myocardial infarction (MI)...
March 15, 2024: European Heart Journal
https://read.qxmd.com/read/38485776/donepezil-attenuates-progression-of-cardiovascular-remodeling-and-improves-prognosis-in-spontaneously-hypertensive-rats-with-chronic-myocardial-infarction
#13
JOURNAL ARTICLE
Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Shohei Yokota, Hiroki Matsushita, Keita Saku
The acetylcholinesterase inhibitor donepezil restores autonomic balance, reduces inflammation, and improves long-term survival in rats with chronic heart failure (CHF) following myocardial infarction (MI). As arterial hypertension is associated with a significant risk of cardiovascular death, we investigated the effectiveness of donepezil in treating CHF in spontaneously hypertensive rats (SHR). CHF was induced in SHR by inducing permanent MI. After 2 weeks, the surviving SHR were randomly assigned to sham-operated (SO), untreated (UT), or oral donepezil-treated (DT, 5 mg/kg/day) groups, and various vitals and parameters were monitored...
March 14, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38485534/automatic-detection-and-tracking-of-anatomical-landmarks-in-transesophageal-echocardiography-for-quantification-of-left-ventricular-function
#14
JOURNAL ARTICLE
Anders Austlid Taskén, Jinyang Yu, Erik Andreas Rye Berg, Bjørnar Grenne, Espen Holte, Håvard Dalen, Stian Stølen, Frank Lindseth, Svend Aakhus, Gabriel Kiss
OBJECTIVE: Evaluation of left ventricular (LV) function in critical care patients is useful for guidance of therapy and early detection of LV dysfunction, but the tools currently available are too time-consuming. To resolve this issue, we previously proposed a method for the continuous and automatic quantification of global LV function in critical care patients based on the detection and tracking of anatomical landmarks on transesophageal heart ultrasound. In the present study, our aim was to improve the performance of mitral annulus detection in transesophageal echocardiography (TEE)...
March 13, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38483601/characterization-of-anthracycline-induced-cardiotoxicity-by-diffusion-tensor-magnetic-resonance-imaging
#15
JOURNAL ARTICLE
David Lohr, Arne Thiele, Max Stahnke, Vera M Braun, Robert Klopfleisch, Oliver Klein, Sandra Dresen, Ulf Landmesser, Anna Foryst-Ludwig, Ulrich Kintscher, Laura M Schreiber, Niklas Beyhoff
Anthracyclines are highly potent anti-cancer drugs, but their clinical use is limited by severe cardiotoxic side effects. The impact of anthracycline-induced cardiotoxicity (AIC) on left ventricular (LV) microarchitecture and diffusion properties remains unknown. This study sought to characterize AIC by cardiovascular magnetic resonance diffusion tensor imaging (DTI). Mice were treated with Doxorubicin (DOX; n = 16) for induction of AIC or saline as corresponding control (n = 15)...
March 14, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38483417/clinical-characterization-of-arrhythmia-induced-cardiomyopathy-in-patients-with-tachyarrhythmia-and-idiopathic-heart%C3%A2-failure
#16
JOURNAL ARTICLE
Christian Schach, Thomas Körtl, Florian Zeman, Bianca Luttenberger, Franziska Mühleck, Paul Baum, Daniel Lavall, Nicola H Vosshage, Markus Resch, Sarah Ripfel, Christine Meindl, Ekrem Ücer, Okka W Hamer, Andrea Baessler, Michael Arzt, Michael Koller, Christian Sohns, Lars S Maier, Rolf Wachter, Samuel Sossalla
BACKGROUND: Arrhythmia-induced cardiomyopathy (AIC) is a known entity, but prospective evidence for its characterization is limited. OBJECTIVES: This study aimed to: 1) determine the relative frequency of the pure form of AIC in the clinically relevant cohort of patients with newly diagnosed, otherwise unexplained left ventricular systolic dysfunction (LVSD) and tachyarrhythmia; 2) assess the time to recovery from LVSD; and 3) identify parameters for an early diagnosis of AIC...
February 28, 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38483076/influence-of-a-7-day-transalpine-trail-run-on-cardiac-biomarkers-and-myocardial-function
#17
JOURNAL ARTICLE
Katrin Esefeld, Marisa Geisberger, Sophia Marie-Theres Dinges, Johanna Hambrecht, Felix Stegmüller, Michael Rasper, Jonathan Nadjiri, Franz Roeschenthaler, Stefan Holdenrieder, Jürgen Scharhag, Martin Halle
Intense physical exercise is known to increase cardiac biomarkers; however, it is unclear, whether this phenomenon is physiological, or if it indicates myocardial tissue injury. The aim of our study was to investigate the effects of seven consecutive days of excessive endurance exercise on continuous assessment of cardiac biomarkers, function, and tissue injury. During a 7-day trail-running competition (Transalpine Run, distance 267.4 km, altitude ascent/descent 15556/14450 m), daily blood samples were obtained for cardiac biomarkers (hs-TnT, NT-proBNP, and suppression of tumorigenicity-2 protein (ST2)) at baseline, after each stage and 24-48 h post-race...
March 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38481642/peripartum-cardiomyopathy-in-patients-with-psychiatric-disorders-successfully-treated-with-bromocriptine-two-case-reports
#18
Haruka Takanaka, Ryohei Ono, Hirotoshi Kato, Togo Iwahana, Tomoki Miyahara, Hidehisa Takahashi, Yasuhiko Hori, Kenichi Fukushima, Yoshio Kobayashi
UNLABELLED: Peripartum cardiomyopathy (PPCM) is a rare disorder in which left ventricular systolic dysfunction and heart failure symptoms occur during the peripartum period. Inhibition of prolactin secretion by bromocriptine mediates beneficial effects on cardiac function in PPCM. Mental disorders are also associated with the onset of PPCM. Psychiatric medications for mental disorders would affect serotonin production and tryptophan and dopamine metabolism, and they are associated with PPCM...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481640/a-case-of-neonatal-fulminant-myocarditis-with-dystrophic-calcification-usefulness-of-two-dimensional-speckle-tracking-echocardiography
#19
Sadahiro Furui, Tomoyuki Sato, Mitsuru Seki
UNLABELLED: Dystrophic calcification is a rare but fatal complication associated with severe myocarditis. Detecting calcified lesions and evaluating ventricular function are essential for the management of myocarditis. We report a case of neonatal acute myocarditis with dystrophic calcification successfully assessed by two-dimensional speckle-tracking echocardiography. The calcification spontaneously resolved, and the recovery of myocardial function was evaluated by speckle-tracking echocardiography...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481638/left-ventricular-apical-aneurysm-caused-by-takotsubo-cardiomyopathy
#20
Masaru Hiki, Tomohi Ajima, Mitsuhiro Takeuchi, Kikuo Isoda
UNLABELLED: A 78-year-old woman with hypertension was admitted to our hospital with palpitation and chest discomfort. She had been nervous since she learned about a severe earthquake on the news. An electrocardiogram showed ST-segment elevation in leads I, aVL, and V2-6. Emergency coronary angiography demonstrated no significant coronary stenosis and left ventriculography revealed marked akinesis of apical left ventricle with hyperkinesis of the basal segments, indicating typical takotsubo cardiomyopathy...
March 2024: Journal of Cardiology Cases
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