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Tigecycline in childrens

Melike Emiroglu, Gulsum Alkan, Hatice Turk Dagi
Shunt infections are seen in 3% to 20% of patients who have cerebrospinal fluid (CSF) shunts. Although the staphylococcal species are the most common cause of shunt-related infections, Gram-negative bacteria are increasingly reported with higher mortality rates. Tigecycline, a glycylcycline, is not approved for children. But in the era of nosocomial infections due to multidrug-resistant pathogens, it can be the life-saving option. We report an infant with ventriculoperitoneal shunt-related meningitis treated with a tigecycline combination regimen...
January 2017: Pediatrics
Mohsen Heidary, Aghil Bahramian, Ali Hashemi, Mehdi Goudarzi, Vahid Fallah Omrani, Gita Eslami, Hossein Goudarzi
BACKGROUND: The distribution of drug resistance among clinical isolates of Escherichia coli and Klebsiella pneumoniae has limited the therapeutic options. The aim of this study was to report the prevalence of quinolone resistance genes among E. coli and K. pneumoniae clinical strains isolated from three educational hospitals of Tehran, Iran. MATERIALS AND METHODS: A total of 100 strains of E. coli from Labbafinejad and Taleghani Hospitals and 100 strains of K. pneumoniae from Mofid Children and Taleghani Hospitals were collected between January 2013 and May 2014...
December 12, 2016: Acta Microbiologica et Immunologica Hungarica
Zheng-Yi Zhu, Ju-Fei Yang, Ying-Hua Ni, Wei-Feng Ye, Jue Wang, Miao-Lian Wu
AIM: This study assessed the efficacy and safety of tigecycline in children with life-threatening infections. METHODS: We retrospectively reviewed the clinical records of patients treated with tigecycline from June 2012 to May 2014 in a Chinese tertiary centre. RESULTS: The study comprised 24 patients (14 male) with a median age of four years (range, 50 days-12 years). The most frequently isolated microorganism, most common isolation site and type of infection were Acinetobacter baumannii, tracheal aspirate fluid and ventilator-associated pneumonia, respectively...
October 2016: Acta Paediatrica
Elias Iosifidis, Asimenia Violaki, Evangelia Michalopoulou, Elena Volakli, Elisavet Diamanti, Dimitrios Koliouskas, Charalampos Antachopoulos, Vasiliki Drossou-Agakidou, Maria Sdougka, Emmanuel Roilides
BACKGROUND: Emergence of extensively drug-resistant (XDR) bacteria has forced clinicians to use off-label antimicrobial agents such as tigecycline. We present our experience on salvage use of tigecycline for the treatment of infections caused by XDR Gram-negative bacteria in critically ill children and review published cases. METHODS: We conducted a retrospective chart review in pediatric departments of a tertiary level hospital from January 2009 to May 2014. Patients were identified using pharmacy database...
March 21, 2016: Journal of the Pediatric Infectious Diseases Society
J Zhu, L Sun, B Ding, Y Yang, X Xu, W Liu, D Zhu, F Yang, H Zhang, F Hu
The purpose of this study was to investigate the epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) in Shanghai Children's Hospital in China. Twenty-two non-duplicate CRKP strains were collected from pediatric patients between March and June in 2014. Antimicrobial susceptibility testing was conducted by the agar dilution method. Beta-lactamases were characterized by polymerase chain reaction (PCR) and DNA sequencing. The transferability of bla NDM-1 was investigated by conjugation experiment...
April 2016: European Journal of Clinical Microbiology & Infectious Diseases
Huliyurdurga S Setty Natrajsetty, Ishwarappa B Vijayalakshmi, Chitra Narasimhan, Cholenahalli N Manjunath
BACKGROUND: Infective endocarditis (IE) is a disease with a highly varied clinical picture. Spread of the infection to the pericardium from the infective endocardium is uncommon and IE involving all 4 cardiac valves is also a very rare occurrence, being more common in intravenous drug users (IVDU). CASE REPORT: A 7-year-old boy had purulent pericarditis with infective endocarditis (IE) on all 4 cardiac valves and vegetation in the left ventricular and right atrial cavity...
April 23, 2015: American Journal of Case Reports
Özlem Özgür Gündeşlioğlu, Tülin Güven Gökmen, Özden Özgür Horoz, Necmi Aksaray, Fatih Köksal, Akgün Yaman, Rıza Dinçer Yıldızdaş, Emre Alhan, Emine Kocabaş, Derya Alabaz
The aim of the present study is to investigate the types of healthcare-associated infections (HC-AIs) caused by Acinetobacter baumannii and the related antibiotic susceptibility patterns as well as the genotypic characteristics of the Acinetobacter baumannii isolates from our center. Sixty-nine Acinetobacter baumannii isolates originating from various samples collected from 69 pediatric patients during their hospital stays were included in the study. The types of healthcare-associated infections caused by these isolates were evaluated, and the antibiotic susceptibility pattern and the genotypic characteristics of the isolates were determined using the pulsed-field gel electrophoresis (PFGE) method...
July 2014: Turkish Journal of Pediatrics
Geoffrey Omuse, Beatrice Kabera, Gunturu Revathi
BACKGROUND: Staphylococcus aureus (S.aureus) is a major cause of both healthcare and community acquired infections. In developing countries, manual phenotypic tests are the mainstay for the identification of staphylococci with the tube and slide coagulase tests being relied upon as confirmatory tests for S. aureus. The subjectivity associated with interpretation of these tests may result in misidentification of coagulase negative staphylococci as S.aureus. Given that antibiotic resistance is more prevalent in CONS, this may result in over estimation of methicillin resistant S...
2014: BMC Infectious Diseases
Sandrine Boisset, Yvan Caspar, Vivien Sutera, Max Maurin
Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones (e.g., ciprofloxacin), the tetracyclines (e.g., doxycycline), and the aminoglycosides (streptomycin and gentamicin). Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F. tularensis also relies on administration of antibiotics. A number of reasons make it necessary to search for new therapeutic alternatives: the potential toxicity of first-line drugs, especially in children and pregnant women; a high rate of treatment relapses and failures, especially for severe and/or suppurated forms of the disease; and the possible use of antibiotic-resistant strains in the context of a biological threat...
2014: Frontiers in Cellular and Infection Microbiology
Martyn Gostelow, Daniel Gonzalez, P Brian Smith, Michael Cohen-Wolkowiez
Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant cause of morbidity in hospitalized infants. Over the past 15 years, several drugs have been approved for the treatment of S. aureus infections in adults (linezolid, quinupristin/dalfopristin, daptomycin, telavancin, tigecycline and ceftaroline). The use of the majority of these drugs has extended into the treatment of MRSA infections in infants, frequently with minimal safety or dosing information. Only linezolid is approved for use in infants, and pharmacokinetic data in infants are limited to linezolid and daptomycin...
May 2014: Expert Review of Clinical Pharmacology
S S Jean, W S Lee, F L Chen, T Y Ou, P R Hsueh
Elizabethkingia meningoseptica has been deemed a potentially important threat to patients in critical care areas because of its multidrug-resistant phenotype and its ability to adapt to various environments. This review considers the incidence, factors which predispose to, and clinical features of, E. meningoseptica sepsis, along with antimicrobial susceptibility patterns of clinical E. meningoseptica isolates and reportedly successful measures for the prevention and control of infections caused by this bacterium...
April 2014: Journal of Hospital Infection
Xiao-min Peng, Peng Yang, Shuang Liu, Jing Li, Dai-tao Zhang, Yi-meng Liu, Hui-jie Liang, Shu-juan Cui, Shuang-sheng Wu, Quan-yi Wang
OBJECTIVE: To investigate the genetic features of drug resistance to group A streptococcus(GAS) and macrolides antibiotics among pediatric patients in Beijing 2012. METHODS: A total of 199 strains of GAS were collected from 36 hospitals in Beijing between May and July, 2012. All strains were isolated from oropharyngeal swabs. The minimum inhibitory concentrations (MICs) of ten antibiotics (penicillin, ampicillin, erythromycin, clindamycin, tetracycline, levofloxacin, tigecycline, vancomycin, linezolid and streptogramin) were detected by VITEK-2 compact with GPS-67 test kit...
November 2013: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Xiaoxing Du, Ying Fu, Yunsong Yu
Tigecycline shows great antimicrobial activity against both Gram-positive and Gram-negative bacteria, and has been considered to be an appropriate choice in controlling infection caused by multi-drug resistant (MDR) pathogens, such as carbapenemase-producing Enterobacteriaceae (CPE). Although many clinical trials evaluate the efficacy and safety of tigecycline on adults, rare reports recommend tigecycline to treat pediatric patient. In this study, we presented a clinical case with tigecycline as an anti-infectious agent on a 14-year-old child who was suffering from infection of intraperitoneal abscess caused by Klebsiella pneumoniae carbapenemases (KPC)-producing Escherichia coli with extreme drug resistant profile...
2013: Annals of Clinical Microbiology and Antimicrobials
M Hackel, C Lascols, S Bouchillon, B Hilton, D Morgenstern, J Purdy
Streptococcus pneumoniae remains a leading cause of disease in children and adults. Serotypes differ in invasiveness, virulence, and antibiotic resistance; therefore, serotype surveillance is necessary to monitor the burden of pneumococcal disease, especially in the setting of pneumococcal vaccination programs. The Tigecycline Evaluation Surveillance Trial, (TEST), is an on-going global antibiotic susceptibility surveillance program. Serotypes and antibiotic susceptibilities of 2173 invasive S. pneumoniae in this existing database during 2004-2008 were evaluated...
October 1, 2013: Vaccine
E A Champion, M B Miller, E B Popowitch, M M Hobbs, L Saiman, M S Muhlebach
OBJECTIVES: The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in cystic fibrosis (CF) patients in the United States is approximately 25%. Little is known about the relative proportion of hospital- versus community-associated strains or the antimicrobial susceptibility of MRSA in different CF centers. We hypothesized that the majority of MRSA isolates obtained from children with CF are those endemic in the hospital and that those associated with community acquisition (SCCmec IV) would be more resistant than typically seen in non-CF MRSA isolates...
March 2014: Pediatric Pulmonology
Yu-San Lin, Min-Hsiang Hung, Chi-Chung Chen, Kuo-Feng Huang, Wen-Chien Ko, Hung-Jen Tang
Necrotizing fasciitis caused by Vibrio vulnificus is rarely reported in children. We describe a 12-year-old immunocompetent boy with necrotizing fasciitis caused by V. vulnificus. He was cured by radical and serial debridement and salvage therapy with intravenous cefpirome plus tigecycline. The in vitro antibacterial activity of combination regimens and a literature review of pediatric V. vulnificus infection are described.
February 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Alicja Sękowska, Eugenia Gospodarek, Dorota Kamińska
INTRODUCTION: Twenty-eight isolates of extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae were studied. MATERIAL AND METHODS: The strains were cultured from different clinical specimens obtained from children hospitalised at the University Hospital in Bydgoszcz. Seventeen strains were isolated from colonization and eleven from clinical infection. Isolation and identification of bacteria were performed using routine methods at the clinical microbiology laboratory...
December 20, 2012: Archives of Medical Science: AMS
Shuang Liu, Jing Li, Xiao-min Peng, Peng Yang, Dai-tao Zhang, Shuang-sheng Wu, Shu-juan Cui, Yi-meng Liu, Quan-yi Wang
OBJECTIVE: To analyze the characteristics of antibiotic resistance on group A streptococcus isolated from pediatrics in Beijing in 2011, to provide reference for clinical drug administration. METHODS: Strains of group A streptococcus were collected from the Departments of Pediatrics in 36 hospitals at different Districts of Beijing, from May to July 2011. Minimal inhibitory concentrations (MIC) with ten antibiotics of these isolates were tested by VITEK 2 Compact method...
November 2012: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Abdullateef A Alzolibani, Ahmad A Al Robaee, Hani A Al Shobaili, Jalal A Bilal, Mohammad Issa Ahmad, Ghada Bin Saif
INTRODUCTION: Staphylococcus aureus is known as a common pathogen in atopic dermatitis. A methicillin-resistant S. aureus strain with reduced susceptibility to vancomycin (VISA/VRSA) is increasing worldwide. The aims of this study were to evaluate the antibiotic-susceptibility pattern of S. aureus isolated from children with atopic dermatitis and to identify the occurrence of resistance to glycopeptide antibiotics. METHODS: Swabs were collected from atopic dermatitis skin lesions of 80 children being treated at dermatology clinics whose ages ranged from 6 months to 15 years in the period from March 2009 to February 2010...
September 2012: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Roman Franiczek, Beata Sobieszczańska, Michał Turniak, Urszula Kasprzykowska, Barbara Krzyzanowska, Katarzyna Jermakow, Grazyna Mokracka-Latajka
BACKGROUND: Escherichia coli remains the principal bacterial pathogen in childhood diarrhea and constitutes an important public health problem, especially in developing countries. Diarrheagenic E. coli strains often display resistance to beta-lactams due to the production of extended-spectrum beta-lactamases (ESBLs). OBJECTIVES: A total of thirty ESBL-producing E. coli strains colonizing the gastrointestinal tracts of children with acute diarrhea were studied in order to determine their antimicrobial susceptibility, adherence patterns to the HEp-2 cell line and phylogenetic background...
March 2012: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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