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Growth hormon in children

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https://www.readbyqxmd.com/read/28231067/the-association-of-peripubertal-serum-concentrations-of-organochlorine-chemicals-and-blood-lead-with-growth-and-pubertal-development-in-a-longitudinal-cohort-of-boys-a-review-of-published-results-from-the-russian-children-s-study
#1
Oleg Sergeyev, Jane S Burns, Paige L Williams, Susan A Korrick, Mary M Lee, Boris Revich, Russ Hauser
Organochlorine chemicals and lead are environmental exposures that have endocrine disrupting properties (EDCs) which interfere with many aspects of hormone action. Childhood and adolescence are windows of susceptibility for adverse health effects of EDCs. Our ongoing study, the Russian Children's Study (RCS), is one of the few longitudinal studies investigating the impact of EDCs on growth and puberty in boys. It is conducted in the historically contaminated city of Chapaevsk, in the Samara region. The study focuses on evaluating the associations of persistent organochlorine chemicals and lead with growth and pubertal timing...
February 23, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28183093/putative-effects-of-obesity-on-linear-growth-and-puberty%C3%A2
#2
Shlomit Shalitin, Wieland Kiess
Childhood obesity is a major public health problem that has grown to epidemic proportions throughout the world. Obesity is influenced by genetic and environmental factors. The nutritional status plays an important role in growth and body weight regulation. Excess adiposity during childhood can affect the process of growth and puberty. Obese children are frequently tall for their age, with accelerated epiphyseal growth plate maturation despite low growth hormone levels. Several regulatory hormones may affect the process of linear growth in the constellation of obesity, as high levels of insulin and leptin are observed in obese children...
February 9, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28178857/dietary-2-oxoglutarate-prevents-bone-loss-caused-by-neonatal-treatment-with-maximal-dexamethasone-dose
#3
Piotr Dobrowolski, Ewa Tomaszewska, Siemowit Muszyński, Tomasz Blicharski, Stefan G Pierzynowski
Synthetic glucocorticoids (GCs) are widely used in the variety of dosages for treatment of premature infants with chronic lung disease, respiratory distress syndrome, allergies, asthma, and other inflammatory and autoimmune conditions. Yet, adverse effects such as glucocorticoid-induced osteoporosis and growth retardation are recognized. Conversely, 2-oxoglutarate (2-Ox), a precursor of glutamine, glutamate, and collagen amino acids, exerts protective effects on bone development. Our aim was to elucidate the effect of dietary administered 2-Ox on bone loss caused by neonatal treatment with clinically relevant maximal therapeutic dexamethasone (Dex) dose...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28178350/effects-of-size-at-birth-childhood-growth-patterns-and-growth-hormone-treatment-on-leukocyte-telomere-length
#4
Carolina C J Smeets, Veryan Codd, Matthew Denniff, Nilesh J Samani, Anita C S Hokken-Koelega
BACKGROUND: Small size at birth and rapid growth in early life are associated with increased risk of cardiovascular disease in later life. Short children born small for gestational age (SGA) are treated with growth hormone (GH), inducing catch-up in length. Leukocyte telomere length (LTL) is a marker of biological age and shorter LTL is associated with increased risk of cardiovascular disease. OBJECTIVES: To investigate whether LTL is influenced by birth size, childhood growth and long-term GH treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28176629/congenital-hypothyroidism-facts-facets-therapy
#5
Yedukondalu Kollati, Ranga Rao Ambati, Prakash Narayana Reddy, N Satya Sampath Kumar, Rajesh K Patel, Vijaya R Dirisala
: Back ground: Thyroid hormone (T3) is essential for normal development of children enabling brain development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no thyroid hormones. Such a condition is termed congenital hypothyroidism (CH). OBJECTIVE: In the present review, a brief back ground about congenital hypothyroidism, factors associated with CH leading to thyroid dysgenesis and thyroid dyshormonogenesis is elaborated...
February 6, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28138333/short-stature-and-hypoparathyroidism-in-a-child-with-kenny-caffey-syndrome-type-2-due-to-a-novel-mutation-in-fam111a-gene
#6
Mary B Abraham, Dong Li, Dave Tang, Susan M O'Connell, Fiona McKenzie, Ee Mun Lim, Hakon Hakonarson, Michael A Levine, Catherine S Choong
BACKGROUND: Hypoparathyroidism in children is a heterogeneous group with diverse genetic etiologies. To aid clinicians in the investigation and management of children with hypoparathyroidism, we describe the phenotype of a 6-year-old child with hypoparathyroidism and short stature diagnosed with Kenny-Caffey syndrome (KCS) Type 2 and the subsequent response to growth hormone (GH) treatment. CASE PRESENTATION: The proband presented in the neonatal period with hypocalcemic seizures secondary to hypoparathyroidism...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/28112592/testicular-enlargement-in-a-pre-pubertal-boy-with-adrenocortical-tumour
#7
Manassawee Korwutthikulrangsri, Duangkamon Wattanatranon, Sumate Teeraratkul, Piyathida Wijarn, Pat Mahachoklertwattana, Preamrudee Poomthavorn
Adrenocortical tumours are rare in children. Virilisation caused by overproduction of adrenal androgens is the most common presentation. The testes of pre-pubertal boys with this tumour are usually small or of pre-pubertal size. A 4.8-year-old boy with an adrenocortical tumour and symmetrical pubertal-sized testes is reported. The serum testosterone level was 204 nmol/L (<0.7), dehydro-epiandrosterone-sulphate 56.7 μmol/L (<1.5) and luteinising and follicle-stimulating hormones were at suppressed levels...
January 23, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28112064/nutrition-infection-and-stunting-the-roles-of-deficiencies-of-individual-nutrients-and-foods-and-of-inflammation-as-determinants-of-reduced-linear-growth-of-children
#8
D Joe Millward
The regulation of linear growth by nutritional and inflammatory influences is examined in terms of growth-plate endochondral ossification, in order to better understand stunted growth in children. Linear growth is controlled by complex genetic, physiological, and nutrient-sensitive endocrine/paracrine/autocrine mediated molecular signalling mechanisms, possibly including sleep adequacy through its influence on growth hormone secretion. Inflammation, which accompanies most infections and environmental enteric dysfunction, inhibits endochondral ossification through the action of mediators including proinflammatory cytokines, the activin A-follistatin system, glucocorticoids and fibroblast growth factor 21 (FGF21)...
January 23, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28104732/iatrogenic-cushing-s-syndrome-due-to-topical-ocular-glucocorticoid-treatment
#9
Daisuke Fukuhara, Toshihiko Takiura, Hiroshi Keino, Annabelle A Okada, Kunimasa Yan
Iatrogenic Cushing's syndrome (CS) is a severe adverse effect of systemic glucocorticoid (GC) therapy in children, but is extremely rare in the setting of topical ocular GC therapy. In this article, we report the case of a 9-year-old girl suffering from idiopathic uveitis who developed CS due to topical ocular GC treatment. She was referred to the ophthalmology department with a complaint of painful eyes, at which time she was diagnosed with bilateral iridocyclitis and started on a treatment of betamethasone sodium phosphate eye drops...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/28101803/lung-retransplantation-in-an-adult-13%C3%A2-years-after-single-lobar-transplant-in-childhood
#10
Seiichiro Sugimoto, Shinji Otani, Takashi Ohki, Takeshi Kurosaki, Kentaroh Miyoshi, Masaomi Yamane, Shinichiro Miyoshi, Takahiro Oto
Single living-donor lobar lung transplantation provides acceptable results for critically ill children; however, an additional lung transplantation may be required in the future as the recipient grows. We describe a case of successful lung retransplantation in a grown-up patient after single lobar lung transplantation in childhood. A 23-year-old man underwent bilateral cadaveric lung retransplantation for chronic lung allograft dysfunction 13 years after right single living-donor lobar transplantation for idiopathic pulmonary arterial hypertension performed at the age of 10 years...
January 18, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28099132/efficacy-of-long-term-growth-hormone-therapy-in-short-non-growth-hormone-deficient-children
#11
Lucia Schena, Cristina Meazza, Sara Pagani, Valeria Paganelli, Elena Bozzola, Carmine Tinelli, Fabio Buzi, Mauro Bozzola
BACKGROUND: In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients. METHODS: We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels...
February 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28068655/carotid-intima-media-thickness-in-children-treated-with-growth-hormone-a-follow-up-study-over-three-years
#12
Juliane Rothermel, Caroline Knop, Nina Lass, Christina Toschke, Rainer Wunsch, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether high doses of growth hormone (GH) may lead to cardiovascular diseases. Therefore, we studied the longitudinal relationships between GH treatment and carotid intima-media thickness (cIMT), which is predictive of the development of atherosclerosis. METHODS: We measured blood pressure, lipids, hemoglobin HbA1c, IGF-1, IGFBP-3, and cIMT in 28 children treated with supraphysiological doses of GH (mean age 9.8 ± 2.2 years, 39% males) and 36 children suffering from GH deficiency (GHD) and treated with physiological doses of GH (mean age 9...
January 10, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28067847/the-impact-of-growth-hormone-therapy-on-the-apoptosis-assessment-in-cd34-hematopoietic-cells-from-children-with-growth-hormone-deficiency
#13
Miłosz Piotr Kawa, Iwona Stecewicz, Katarzyna Piecyk, Edyta Paczkowska, Dorota Rogińska, Anna Sobuś, Karolina Łuczkowska, Ewa Pius-Sadowska, Elżbieta Gawrych, Elżbieta Petriczko, Mieczysław Walczak, Bogusław Machaliński
Growth hormone (GH) modulates hematopoietic cell homeostasis and is associated with apoptosis control, but with limited mechanistic insights. Aim of the study was to determine whether GH therapeutic supplementation (GH-TS) could affect apoptosis of CD34+ cells enriched in hematopoietic progenitor cells of GH deficient (GHD) children. CD34+ cells from peripheral blood of 40 GHD children were collected before and in 3rd and 6th month of GH-TS and compared to 60 controls adjusted for bone age, sex, and pubertal development...
January 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28043700/prenatal-di-2-ethylhexyl-phthalate-exposure-and-disruption-of-adrenal-androgens-and-glucocorticoids-levels-in-cord-blood-the-hokkaido-study
#14
Atsuko Araki, Takahiko Mitsui, Houman Goudarzi, Tamie Nakajima, Chihiro Miyashita, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
Di(2-ethylhexyl) phthalate (DEHP) is known for its endocrine disrupting properties. We previously demonstrated that prenatal DEHP exposure is associated with decreased progesterone levels and testosterone/estradiol ratio in the cord blood. However, evidence of the effects of prenatal DEHP exposure on adrenal androgen and glucocorticoids in infants is scarce. Thus, the objectives of this study were to investigate the association between prenatal DEHP exposure and adrenal androgen and glucocorticoids, and to discuss its effects on steroid hormone profiles in infants...
December 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28032143/an-evidence-based-review-of-the-genotoxic-and-reproductive-effects-of-sulfur-mustard
#15
REVIEW
Fazlullah Khan, Kamal Niaz, Fatima Ismail Hassan, Mohammad Abdollahi
Sulfur mustard (SM) is a chemical warfare agent which is cytotoxic in nature, and at the molecular level, SM acts as DNA alkylating agent leading to genotoxic and reproductive effects. Mostly, the exposed areas of the body are the main targets for SM; however, it also adversely affects various tissues of the body and ultimately exhibits long-term complications including genotoxic and reproductive effects, even in the next generations. The effect of SM on reproductive system is the reason behind male infertility...
December 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/28011067/metabolic-health-of-young-adults-who-were-born-small-for-gestational-age-and-treated-with-growth-hormone-after-cessation-of-growth-hormone-treatment-a-5-year-longitudinal-study
#16
Manouk van der Steen, Carolina C J Smeets, Gerthe F Kerkhof, Anita C S Hokken-Koelega
BACKGROUND: Growth hormone treatment reduces fat mass and insulin sensitivity and increases lean body mass. Data are only available for short-term longitudinal changes after cessation of growth hormone treatment in young adults born small for gestational age. We aimed to assess long-term changes over a 5-year period following cessation of growth hormone treatment. METHODS: We did a longitudinal study of young adults born small for gestational age and previously treated with growth hormone...
December 20, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28009526/pubertal-progression-and-reproductive-hormones-in-healthy-girls-with-transient-thelarche
#17
Marie Lindhardt Johansen, Casper P Hagen, Mikkel G Mieritz, Ole D Wolthers, Carsten Heuck, Jørgen Holm Petersen, Anders Juul
CONTEXT: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse and the phenomenon of transient thelarche (TT), defined as the appearance, regression and subsequent reappearance of breast buds, in healthy girls remains undescribed. OBJECTIVE: To describe TT in terms of pubertal progression, growth, genotypes and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair and menarche. DESIGN: A prospective, longitudinal population-based study...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28002818/safety-outcomes-and-near-adult-height-gain-of-growth-hormone-treated-children-with-shox-deficiency-data-from-an-observational-study-and-a-clinical-trial
#18
Imane Benabbad, Myriam Rosilio, Christopher J Child, Jean-Claude Carel, Judith L Ross, Cheri L Deal, Stenvert L S Drop, Alan G Zimmermann, Nan Jia, Charmian A Quigley, Werner F Blum
BACKGROUND/AIMS: To assess auxological and safety data for growth hormone (GH)-treated children with SHOX deficiency. METHODS: Data were examined for GH-treated SHOX-deficient children (n = 521) from the observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS). For patients with near-adult height information, GeNeSIS results (n = 90) were compared with a clinical trial (n = 28) of SHOX-deficient patients. Near-adult height was expressed as standard deviation score (SDS) for chronological age, potentially increasing the observed effect of treatment...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28001454/metabolic-health-and-long-term-safety-of-growth-hormone-treatment-in-silver-russell-syndrome
#19
C C J Smeets, J S Renes, M van der Steen, A C S Hokken-Koelega
CONTEXT: Children with Silver-Russell syndrome (SRS) are born small for gestational age (SGA) and remain short. Growth hormone (GH)-treatment improves height in short SGA children, including those with SRS. Data on metabolic health and long-term safety of GH-treatment in SRS are lacking. OBJECTIVE: To investigate metabolic health in SRS patients during and until two years after discontinuation of GH-treatment. DESIGN: Metabolic health was assessed longitudinally at GH-start, GH-stop, and six months and two years thereafter...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27992610/maternal-preeclampsia-and-androgens-in-the-offspring-around-puberty-a-follow-up-study
#20
Ingvild V Alsnes, Imre Janszky, Bjørn O Åsvold, Inger Økland, Michele R Forman, Lars J Vatten
BACKGROUND: Children born after preeclampsia may have a dominant androgen profile in puberty compared with other children. Circulating androgen concentrations at 11-12 years of age were compared between offspring born after preeclampsia, and children whose mothers did not have preeclampsia. METHODS: A total of 611 mother-offspring pairs were followed up 11 (daughters) or 12 (sons) years after birth: 218 pairs in the preeclampsia group, and 383 pairs without preeclampsia...
2016: PloS One
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