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https://www.readbyqxmd.com/read/29207898/nr3c1-gene-polymorphisms-are-associated-with-steroid-resistance-in-patients-with-primary-nephrotic-syndrome
#1
Jie Liu, Zan Wan, Qianqian Song, Zhi Li, Yijing He, Yongjun Tang, Wanying Xie, Yanyun Xie, Jun Zhang
AIM: The aim of this study was to investigate the role of SNPs of genes involved in the glucocorticoid pathway in the development of steroid resistance in patients with primary nephrotic syndrome. METHODS: Sequenom MassARRAY method was used to sequence 25 SNP genotypes in 154 patients. The frequency distribution of the genotypes was compared between patients with steroid-sensitive nephrotic syndrome and those with steroid-resistant nephrotic syndrome. RESULTS: NR3C1 rs6196 G allele carriers had a decreased risk of steroid resistance compared with that of the A allele carriers...
December 6, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29204180/cytotoxic-effects-of-the-newly-developed-chemotherapeutic-agents-17-aag-in-combination-with-oxaliplatin-and-capecitabine-in-colorectal-cancer-cell-lines
#2
Mahshid Mohammadian, Shima Zeynali, Anahita Fathi Azarbaijani, Mohammad Hassan Khadem Ansari, Fatemeh Kheradmand
The use of heat shock protein 90 inhibitors like 17-allylamino-17-demethoxy-geldanamycin (17-AAG) has been recently introduced as an attractive anticancer therapy. It has been shown that 17-AAG may potentiate the inhibitory effects of some classical anticolorectal cancer (CRC) agents. In this study, two panels of colorectal carcinoma cell lines were used to evaluate the effects of 17-AAG in combination with capecitabine and oxaliplatin as double and triple combination therapies on the proliferation of CRC cell lines...
December 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29202196/effects-of-dlc1-deficiency-on-endothelial-cell-contact-growth-inhibition-and-angiosarcoma-progression
#3
David Sánchez-Martín, Atsushi Otsuka, Kenji Kabashima, Taekyu Ha, Dunrui Wang, Xiaolan Qian, Douglas R Lowy, Giovanna Tosato
Background: Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene frequently deleted in cancer. However, DLC1 is not known to be deleted in angiosarcoma, an aggressive malignancy of endothelial cell derivation. Additionally, the physiologic functions of DLC1 protein in endothelial cells are poorly defined. Methods: We investigated the effects of shRNA-induced DLC1 depletion in endothelial cells. Cell growth was measured by 3H thymidine incorporation, IncuCyte imaging, and population doublings; cell death by cell cycle analysis; gene expression by Affimetrix arrays and quantitative polymerase chain reaction; NF-κB activity by reporter assays; and protein levels by immunoblotting and immunofluorescence staining...
November 30, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29198736/venous-thromboembolic-complications-to-hysterectomy-for-benign-disease-a-nationwide-cohort-study
#4
Henriette Strøm Kahr, Ole Thorlacius-Ussing, Ole Bjarne Christiansen, Regitze Kuhr Skals, Christian Torp-Pedersen, Aage Knudsen
STUDY OBJECTIVE: To estimate the risk of venous thromboembolic complications following abdominal, laparoscopic and vaginal hysterectomy when performed for benign disorders. DESIGN: Nationwide cohort study (Canadian Task Force Classification II-2). SETTING: Data from Danish national registers on all women undergoing hysterectomy for benign conditions in the period 1996-2015. PATIENTS: Women aged 18 and above who underwent hysterectomy for benign disease were stratified into 3 groups according to hysterectomy approach: abdominal, laparoscopic or vaginal...
November 30, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29188602/-rare-thalassemia-mutations-among-southern-chinese-population
#5
Fen Lin, Liye Yang, Min Lin, Xiangbian Zheng, Min Lu, Meilan Qiu, Liejun Li, Longxu Xie
OBJECTIVE: To detect rare types of thalassemia mutations among southern Chinese population. METHODS: Peripheral blood samples from 327 patients from various regions of southern China were collected. The patients were suspected as rare-type thalassemia for their inconsistency between hematological phenotypes and results of routine mutation screening. The samples were further analyzed with GAP-PCR and DNA sequencing. RESULTS: One hundred and eight cases were diagnosed as rare types of thalassemia...
December 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29148771/an-qm-mm-study-of-the-reaction-catalyzed-by-alkyladenine-dna-glycosylase-examination-of-the-substrate-specificity-of-a-dna-repair-enzyme
#6
Stefan A P Lenz, Stacey D Wetmore
Human alkyladenine DNA glycosylase (AAG) functions as part of the base excision repair pathway to excise structurally diverse oxidized and alkylated DNA purines. Specifically, AAG uses a water molecule activated by a general base and a non-specific active site lined with aromatic residues to cleave the N-glycosidic bond. Despite broad substrate specificity, AAG does not target the natural purines (adenine (A) and guanine (G)). Using the ONIOM(QM:MM) methodology, we provide fundamental atomic level details of AAG bound to DNA-containing a neutral substrate (hypoxanthine (Hx)), a non-substrate (G), or a cationic substrate (7-methylguanine (7MeG)), and probe changes in the reaction pathway that occur when AAG targets different nucleotides...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29145117/biodiesel-production-from-microbial-granules-in-sequencing-batch-reactor
#7
Lin Liu, Yuling Hong, Xin Ye, Lili Wei, Jie Liao, Xu Huang, Chaoxiang Liu
Effect of reaction variables of in situ transesterification on the biodiesel production, and the characteristic differences of biodiesel obtained from aerobic granular sludge (AG) and algae-bacteria granular consortia (AAG) were investigated. The results indicated that the effect of variables on the biodiesel yield decreased in the order of methanol quantity > catalyst concentration > reaction time, yet the parameters change will not significantly affect biodiesel properties. The maximum biodiesel yield of AAG was 66...
November 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29137680/correction-to-development-of-molecular-confirmation-tools-for-swift-and-easy-rabies-diagnostics
#8
Kore Schlottau, Conrad M Freuling, Thomas Müller, Martin Beer, Bernd Hoffmann
After publication of the article [1], it has been brought to our attention that an incorrect genetic sequence has been cited. On page 4, paragraph 1 the following sequence is cited "ATG GAT GCC GAC AAG ATT GTM TTY AAA GTY AAT A 3". This is an error and the correct sequence should be "GGG GGC TTT YCC TAG GGT KAT ACW GGG CTT T 3".
November 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/29114181/kinetic-modelling-of-infection-tracers-18-f-fdg-68-ga-ga-citrate-11-c-methionine-and-11-c-donepezil-in-a-porcine-osteomyelitis-model
#9
Lars Jødal, Svend B Jensen, Ole L Nielsen, Pia Afzelius, Per Borghammer, Aage K O Alstrup, Søren B Hansen
Introduction: Positron emission tomography (PET) is increasingly applied for infection imaging using [(18)F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [(18)F]FDG and three other PET tracers with relevance for infection imaging. Methods: A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [(18)F]FDG, [(68)Ga]Ga-citrate, [(11)C]methionine, and/or [(11)C]donepezil, along with blood sampling...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29105766/the-cotton-gossypium-hirsutum-nac-transcription-factor-fsn1-as-a-positive-regulator-participates-in-controlling-secondary-cell-wall-biosynthesis-and-modification-of-fibers
#10
Jie Zhang, Geng-Qing Huang, Dan Zou, Jing-Qiu Yan, Yang Li, Shan Hu, Xue-Bao Li
Cotton (Gossypium hirsutum) fibers are the highly elongated and thickened single-cell trichomes on the seed epidermis. However, little is known about the molecular base of fiber cell wall thickening in detail. In this study, a cotton NAC transcription factor (GhFSN1) that is specifically expressed in secondary cell wall (SCW) thickening fibers was functionally characterized. The GhFSN1 transgenic cotton plants were generated to study how FSN1 regulates fiber SCW formation. Up-regulation of GhFSN1 expression in cotton resulted in an increase in SCW thickness of fibers but a decrease in fiber length...
November 6, 2017: New Phytologist
https://www.readbyqxmd.com/read/29101617/quality-of-medication-information-in-discharge-summaries-from-hospitals-an-audit-of-electronic-patient-records
#11
Beate Hennie Garcia, Berit Svendsen Djønne, Frode Skjold, Ellen Marie Mellingen, Trine Iversen Aag
Background Low quality of medication information in discharge summaries from hospitals may jeopardize optimal therapy and put the patient at risk for medication errors and adverse drug events. Objective To audit the quality of medication information in discharge summaries and explore factors associated with the quality. Setting Helgelandssykehuset Mo i Rana, a rural hospital in central Norway. Method For each month in 2013, we randomly selected 60 discharge summaries from the Department of Medicine and Surgery (totally 720) and evaluated the medication information using eight Norwegian quality criteria...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29097917/post-mortem-leukocyte-scintigraphy-in-juvenile-pigs-with-experimentally-induced-osteomyelitis
#12
Pia Afzelius, Ole Lerberg Nielsen, Svend Borup Jensen, Aage Kristian Olsen Alstrup
We have previously demonstrated that (111)In-labeled autologous leukocyte scintigraphy is able to detect osteomyelitis in living juvenile pigs. In animal research studies, it may well be an advantage if the animals could be scanned after euthanasia. Applying traditional scanning of living animals to euthanized animals will render anaesthesia unnecessary and be ideal for obtaining good and reliable scans for the correct interpretation of imaging afterwards, since the animals do not move. The autologous leukocytes of the pigs were collected, marked with (111)In, and reinjected into the pigs and allowed for homing to the site of infections as usual while the pigs were alive...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097911/micropet-ct-imaging-of-axl-downregulation-by-hsp90-inhibition-in-triple-negative-breast-cancer
#13
Wanqin Wang, Jun Zhao, Xiaoxia Wen, Curtis Chun-Jen Lin, Junjie Li, Qian Huang, Yongqiang Yu, Shiaw-Yih Lin, Chun Li
AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC). AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT) and a potential therapeutic target for TNBC. In this work, we used microPET/CT with (64)Cu-labeled anti-human AXL antibody ((64)Cu-anti-hAXL) to noninvasively interrogate the degradation of AXL in vivo in response to 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent inhibitor of HSP90. 17-AAG treatment caused significant decline in AXL expression in orthotopic TNBC MDA-MB-231 tumors, inhibited EMT, and delayed tumor growth in vivo, resulting in significant reduction in tumor uptake of (64)Cu-anti-hAXL as clearly visualized by microPET/CT...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29075213/monoamine-oxidase-a-maoa-gene-and-personality-traits-from-late-adolescence-through-early-adulthood-a-latent-variable-investigation
#14
Man K Xu, Darya Gaysina, Roula Tsonaka, Alexandre J S Morin, Tim J Croudace, Jennifer H Barnett, Jeanine Houwing-Duistermaat, Marcus Richards, Peter B Jones
Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29075081/co-inheritance-of-hb-j-kaohsiung-%C3%AE-59-e3-aag-acg-lys%C3%A2-thr-and-hbe-%C3%AE-26-b8-gag-aag-glu%C3%A2-lys-in-a-thai-woman
#15
Sitthichai Panyasai, Sakorn Pornprasert
No abstract text is available yet for this article.
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29073808/whole-body-biodistribution-dosimetry-and-metabolite-correction-of-11-c-palmitate-a-pet-tracer-for-imaging-of-fatty-acid-metabolism
#16
Nana L Christensen, Steen Jakobsen, Anna C Schacht, Ole L Munk, Aage K O Alstrup, Lars P Tolbod, Hendrik J Harms, Søren Nielsen, Lars C Gormsen
INTRODUCTION: Despite the decades long use of [(11)C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published. METHODS: Dosimetry and biodistribution studies were performed in 2 pigs and 2 healthy volunteers by whole-body [(11)C]palmitate PET scans. Metabolite studies were performed in 40 participants (healthy and with type 2 diabetes) under basal and hyperinsulinemic conditions...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/29070467/-comparison-of-postoperative-drainage-and-systemic-trauma-response-after-endoscopic-and-traditional-near-total-thyroidectomy
#17
Yong-Quan Zhang, Zhi-Chao Li, Fei Chen, Hong-Juan Wang, Qiang Li
OBJECTIVE: To investigate the difference of postoperative drainage and systemic trauma response between endoscopic and traditional near total thyroidectomy to provide the basis for selecting appropriate operative methods. METHODS: In this prospective clinical controlled study, 80 patientsscheduled for near total bilateral thyroidectomy for the first time were divided equally into endoscopic surgery group (group A) and open surgery group (group B). The total drainage volume after operation, postoperative extubation time, and postoperative daily drainage volume were recorded after the operation...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29059373/genome-wide-interaction-study-of-smoking-behavior-and-non-small-cell-lung-cancer-risk-in-caucasian-population
#18
Yafang Li, Xiangjun Xiao, Younghun Han, Olga Gorlova, David Qian, Natasha Leighl, Jakob S Johansen, Matt Barnett, Chu Chen, Gary Goodman, Angela Cox, Fiona Taylor, Penella Woll, H-Erich Wichmann, Judith Manz, Thomas Muley, Angela Risch, Albert Rosenberger, Susanne M Arnold, Eric B Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Shanbeh Zienolddiny, Eric J Duell, Lesley M Butler, Richard Houlston, María Soler Artigas, Kjell Grankvist, Mikael Johansson, Frances A Shepherd, Michael W Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Geoffrey Liu, Stig E Bojesen, Xifeng Wu, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C Aldrich, William S Bush, Adonina Tardon, Gad Rennert, M Dawn Teare, John K Field, Lambertus A Kiemeney, Philip Lazarus, Aage Haugen, Stephen Lam, Matthew B Schabath, Angeline S Andrew, Pier Alberto Bertazzi, Angela C Pesatori, David C Christiani, Neil Caporaso, Mattias Johansson, James D McKay, Paul Brennan, Rayjean J Hung, Christopher I Amos
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between SNPs and smoking status (never vs ever smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13,336 NSCLC cases. Candidate SNPs with p-value less than 0...
October 20, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29056443/pre-clinical-evaluation-of-a-themosensitive-gel-containing-epothilone-b-and-mtor-hsp90-targeted-agents-in-an-ovarian-tumor-model
#19
Dae Hwan Shin, Glen S Kwon
Despite clinical remission of epithelial ovarian cancer (EOC) after surgical resection and first-line chemotherapy, about 60% of patients will re-develop peritoneal metastasis and about 50% will relapse with chemoresistant disease. Clinical studies suggest that intra-peritoneal (i.p.) chemotherapy effectively treats residual EOC after cyto-reduction by gaining direct access into the peritoneal cavity, enabling elevated drug levels versus intravenous (i.v.) injection. However, chemoresistant disease is still problematic...
October 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29054380/toxicity-and-efficacy-of-re-irradiation-of-high-grade-glioma-in-a-phase-i-dose-and-volume-escalation-trial
#20
Søren Møller, Per Munck Af Rosenschöld, Junia Costa, Ian Law, Hans Skovgaard Poulsen, Svend Aage Engelholm, Silke Engelholm
INTRODUCTION: The purpose of this study was to evaluate the safety and efficacy of PET and MRI guided re-irradiation of recurrent high-grade glioma (HGG) and to assess the impact of radiotherapy dose, fractionation and irradiated volume. MATERIAL AND METHODS: Patients with localized, recurrent HGG (grades III-IV) and no other treatment options were eligible for a prospective phase I trial. Gross tumor volumes for radiotherapy were defined using T1-contrast enhanced MRI and 18F-fluoro-ethyl tyrosine PET...
November 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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