keyword
MENU ▼
Read by QxMD icon Read
search

AAG

keyword
https://www.readbyqxmd.com/read/29032866/hsp90-maintains-boar-spermatozoa-motility-and-mitochondrial-membrane-potential-during-heat-stress
#1
V Calle-Guisado, M J Bragado, L J García-Marín, L González-Fernández
Heat Shock Proteins (HSP) is a family of proteins that protects cells from high temperatures. The present work aimed to elucidate the role that HSP90 exerts on boar sperm incubated under heat stress conditions on viability, total motility (TM), progressive motility (PM), acrosome status, mitochondrial membrane potential and plasma membrane lipid organization. Sperm were incubated in non-capacitating conditions (Tyrode's basal medium or TBM) for 3, 8 and 24h or in capacitating conditions (Tyrode's complete medium or TCM) for 4h at 38...
September 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28986702/a-revision-of-the-tokuhashi-revised-score-improves-the-prognostic-ability-in-patients-with-metastatic-spinal-cord-compression
#2
Søren Schmidt Morgen, Sidsel Fruergaard, Martin Gehrchen, Sebastian Bjørck, Svend Aage Engelholm, Benny Dahl
PURPOSE: The Tokuhashi revised score from 2005 (TR2005) is the most recommended prognostic scoring system in patients with metastatic spinal cord compression (MSCC). However, recent studies have questioned its prognostic ability and the need for a new revision has been proposed. We aimed to assess whether a revision of the TR2005 can improve the prognostic ability of the scoring system. METHODS: In 2011 and 2012, a total of 1143 consecutive patients admitted with MSCC were prospectively included in a 2011 and a 2012 cohort...
October 6, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28983611/suppression-by-hsp90-inhibitors-of-bmp%C3%A2-4%C3%A2-stimulated-osteoprotegerin-synthesis-in-osteoblasts-attenuation-of-p70-s6-kinase
#3
Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Shingo Kainuma, Naohiro Yamamoto, Gen Kuroyanagi, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Heat shock protein 90 (HSP90) is an ATP‑dependent ubiquitous molecular chaperon which is important in cell homeostasis. The authors previously demonstrated that bone morphogenetic protein (BMP)‑4 stimulates osteoprotegerin (OPG) production in osteoblast‑like MC3T3‑E1 cells, and that p70 S6 kinase positively regulates the OPG synthesis by BMP‑4. The present study investigated the involvement of HSP90 in the BMP‑4‑stimulated OPG synthesis and the mechanism in MC3T3‑E1 cells. HSP90 inhibitors, 17‑allylamino‑17demethoxy‑geldanamycin (17‑AAG), 17‑dimethylamino‑ethylamino‑17‑demethoxy‑geldanamycin (17‑DMAG) and geldanamycin significantly suppressed the BMP‑4‑stimulated OPG release...
September 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28980645/giga-voxel-computational-morphogenesis-for-structural-design
#4
Niels Aage, Erik Andreassen, Boyan S Lazarov, Ole Sigmund
In the design of industrial products ranging from hearing aids to automobiles and aeroplanes, material is distributed so as to maximize the performance and minimize the cost. Historically, human intuition and insight have driven the evolution of mechanical design, recently assisted by computer-aided design approaches. The computer-aided approach known as topology optimization enables unrestricted design freedom and shows great promise with regard to weight savings, but its applicability has so far been limited to the design of single components or simple structures, owing to the resolution limits of current optimization methods...
October 4, 2017: Nature
https://www.readbyqxmd.com/read/28978150/parp-inhibitors-protect-against-sex-and-aag-dependent-alkylation-induced-neural-degeneration
#5
Mariacarmela Allocca, Joshua J Corrigan, Kimberly R Fake, Jennifer A Calvo, Leona D Samson
Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage healthy tissues. The initiation of BER by the alkyladenine DNA glycosylase (AAG, a.k.a. MPG) can mediate alkylation-induced cytotoxicity in specific cells in the retina and cerebellum of male mice. Cytotoxicity in both wild-type and Aag-transgenic (AagTg) mice is abrogated in the absence of Poly(ADP-ribose) polymerase-1 (PARP1)...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28964587/feasibility-of-pencil-beam-scanned-intensity-modulated-proton-therapy-in-breath-hold-for-locally-advanced-non-small-cell-lung-cancer
#6
Jenny Gorgisyan, Per Munck Af Rosenschold, Rosalind Perrin, Gitte F Persson, Mirjana Josipovic, Maria Francesca Belosi, Svend Aage Engelholm, Damien C Weber, Antony J Lomax
PURPOSE: We evaluated the feasibility of treating patients with locally advanced non-small cell lung cancer (NSCLC) with pencil beam scanned intensity modulated proton therapy (IMPT) in breath-hold. METHODS AND MATERIALS: Fifteen NSCLC patients who had previously received 66 Gy in 33 fractions with image guided photon radiation therapy were included in the present simulation study. In addition to a planning breath-hold computed tomography (CT) scan before the treatment start, a median of 6 (range 3-9) breath-hold CT scans per patient were acquired prospectively throughout the radiation therapy course...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28954352/-hsp90-inhibitor-17-aag-plays-an-important-role-in-jak3-stat5-signaling-pathways-in-htlv-1-infection-cell-line-hut-102
#7
Q Q Yang, H Tan, Z P Fu, Q Ma, J L Song
Objective: To analyze whether heat-shock protein 90 (HSP90) be involved in a permanently abnormal activated JAK/STAT signaling in ATL cells in vitro. Methods: The effect of 17-AAG on proliferation of ATL cell lines HUT-102 was assessed using CCK8 at different time points. Cell apoptosis was measured by flow cytometry. The specific proteins HSP90, STAT5, p-STAT5 and JAK3 were detected by Western blotting. Results: Overexpression of HSP90 in HUT-102 cell lines was disclosed (P<0.05) , and constitutive activation of JAK3/STAT5 signaling was observed in HTLV-1-infected T-cell lines but not in normal PBMCs; Treatment of ATL cell lines with 17-AAG led to reduced cell proliferation, but there was no significant change in terms of cell proliferation when the concentration of 17-AAG between 2 000-8 000 nmol/L (P>0...
August 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28936570/consumption-of-alcohol-and-cardiovascular-disease-mortality-a-16%C3%A2-year-follow-up-of-115-592-norwegian-men-and-women-aged-40-44%C3%A2-years
#8
Aage Tverdal, Per Magnus, Randi Selmer, Dag Thelle
We tested whether teetotalism explains the upturn in cardiovascular risk for non-drinkers and whether wine is a more favorable alcohol type. We studied 115,592 men and women aged 40-44 years who participated in the age 40 program in Norway in 1994-1999 and were followed for an average of 16 years with 550 cardiovascular deaths. Self-reported number of glasses of beer, wine and spirits during 14 days was transformed to alcohol units/day. One unit is approximately 8 grams of pure alcohol. The mean and median number of alcohol units/day were 0...
September 21, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28902884/development-of-est-ssr-markers-in-flowering-chinese-cabbage-brassica-campestris-l-ssp-chinensis-var-utilis-tsen-et-lee-based-on-de-novo-transcriptomic-assemblies
#9
Jingfang Chen, Ronghua Li, Yanshi Xia, Guihua Bai, Peiguo Guo, Zhiliang Wang, Hua Zhang, Kadambot H M Siddique
Flowering Chinese cabbage is one of the most important vegetable crops in southern China. Genetic improvement of various agronomic traits in this crop is underway to meet high market demand in the region, but the progress is hampered by limited number of molecular markers available in this crop. This study aimed to develop EST-SSR markers from transcriptome sequences generated by next-generation sequencing. RNA-seq of eight cabbage samples identified 48,975 unigenes. Of these unigenes, 23,267 were annotated in 56 gene ontology (GO) categories, 6,033 were mapped to 131 KEGG pathways, and 7,825 were assigned to clusters of orthologous groups (COGs)...
2017: PloS One
https://www.readbyqxmd.com/read/28886188/alkylation-induced-cerebellar-degeneration-dependent-on-aag-and-parp1-does-not-occur-via-previously-established-cell-death-mechanisms
#10
Carrie M Margulies, Isaac Alexander Chaim, Aprotim Mazumder, June Criscione, Leona D Samson
Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a multi-enzyme pathway initiated by the alkyladenine DNA glycosylase (Aag, also known as Mpg). Previous work demonstrated that mice treated with the alkylating agent methyl methanesulfonate (MMS) undergo cerebellar degeneration in an Aag-dependent manner, whereby increased BER initiation by Aag causes increased tissue damage that is dependent on activation of poly (ADP-ribose) polymerase 1 (Parp1)...
2017: PloS One
https://www.readbyqxmd.com/read/28869891/synthesis-and-biological-effect-of-chrom-4-one-derivatives-as-functional-inhibitors-of-heat-shock-protein-27
#11
Soo-Yeon Hwang, Soo Yeon Kwak, Youngjoo Kwon, Yun-Sil Lee, Younghwa Na
Heat Shock Protein 27 (HSP27) is a member of small heat shock proteins with a highly-conserved α-crystalline domain. It inhibits aggregation of damaged proteins through a complex structural systems of phosphorylation-dependent oligomerization and self-assembly. It has been demonstrated that HSP27 is involved in a variety of pathophysiological pathways with negative or positive protective activities. In this study, we synthesized six chromone analogs possessing thiiran-2-ylmethoxy or oxyran-2-ylmethoxy substituents and evaluated their biological activities against HSP27 protein...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28830495/new-insights-into-hcv-replication-in-original-cells-from-aedes-mosquitoes
#12
Catherine Fallecker, Alban Caporossi, Yassine Rechoum, Frederic Garzoni, Sylvie Larrat, Olivier François, Pascal Fender, Patrice Morand, Imre Berger, Marie-Anne Petit, Emmanuel Drouet
BACKGROUND: The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of HCV E1E2 glycoproteins to bind on Aedes mosquito cells and (ii) the ability of HCV serum particles (HCVsp) to replicate in these cell lines. METHODS: First, we used purified E1E2 expressing baculovirus-derived HCV pseudo particles (bacHCVpp) so we could investigate their association with mosquito cell lines from Aedes aegypti (Aag-2) and Aedes albopictus (C6/36)...
August 22, 2017: Virology Journal
https://www.readbyqxmd.com/read/28820017/directive-and-nondirective-social-support-in-the-workplace-is-this-social-support-distinction-important-for-subjective-health-complaints-job-satisfaction-and-perception-of-job-demands-and-job-control
#13
Tone Langjordet Johnsen, Hege Randi Eriksen, Aage Indahl, Torill Helene Tveito
AIMS: Social support is associated with well-being and positive health outcomes. However, positive outcomes of social support might be more dependent on the way support is provided than the amount of support received. A distinction can be made between directive social support, where the provider resumes responsibility, and nondirective social support, where the receiver has the control. This study examined the relationship between directive and nondirective social support, and subjective health complaints, job satisfaction and perception of job demands and job control...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28811486/detecting-human-melanoma-cell-re-differentiation-following-braf-or-heat-shock-protein-90-inhibition-using-photoacoustic-and-magnetic-resonance-imaging
#14
Anant Shah, Teresa Delgado-Goni, Teresa Casals Galobart, Slawomir Wantuch, Yann Jamin, Martin O Leach, Simon P Robinson, Jeffrey Bamber, Mounia Beloueche-Babari
Targeted therapies specific to the BRAF-MEK-ERK signaling pathway have shown great promise in the treatment of malignant melanoma in the last few years, with these drugs now commonly used in clinic. Melanoma cells treated using these agents are known to exhibit increased levels of melanin pigment and tyrosinase activity. In this study we assessed the potential of non-invasive imaging approaches (photoacoustic imaging (PAI) and magnetic resonance imaging (MRI)) to detect melanin induction in SKMEL28 human melanoma cells, following inhibition of Hsp90 and BRAF signaling using 17-AAG and vemurafenib, respectively...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803697/tumor-necrosis-factor-alpha-gene-polymorphisms-and-haplotypes-in-egyptian-children-with-nephrotic-syndrome
#15
Doaa M Youssef, Amal S El-Shal, Samia Hussein, Khaled Salah, Abd El Rahman E Ahmed
BACKGROUND: Nephrotic syndrome (NS) characterized by complex pathogenesis and clinical course with relapses; and needs novel breakthroughs for decades. Polymorphisms of cytokines genes including tumor necrosis factor alpha (TNF-α)may influence susceptibility to NS as well as different patients' steroid responses. In the current study, we demonstrated the potential roles of TNF-α promoter gene polymorphisms [-238, -308, -863] and haplotypes in susceptibility to childhood NS. Also, elucidating their possible influence on patients' steroid response and serum TNF-α level...
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28793157/association-of-previous-cesarean-delivery-with-surgical-complications-after-a-hysterectomy-later-in-life
#16
Sofie A I Lindquist, Neel Shah, Charlotte Overgaard, Christian Torp-Pedersen, Karin Glavind, Thomas Larsen, Avery Plough, Grace Galvin, Aage Knudsen
Importance: In recent decades, the global rates of cesarean delivery have rapidly increased. Nonetheless, the influence of cesarean deliveries on surgical complications later in life has been understudied. Objective: To investigate whether previous cesarean delivery increases the risk of reoperation, perioperative and postoperative complications, and blood transfusion when undergoing a hysterectomy later in life. Design, Setting, and Participants: This registry-based cohort study used data from Danish nationwide registers on all women who gave birth for the first time between January 1, 1993, and December 31, 2012, and underwent a benign, nongravid hysterectomy between January 1, 1996, and December 31, 2012...
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28783748/heat-shock-protein-90-localizes-to-the-surface-and-augments-virulence-factors-of-cryptococcus-neoformans
#17
Sharanya Chatterjee, Utpal Tatu
BACKGROUND: Thermotolerance is an essential attribute for pathogenesis of Cryptococcus as exemplified by the fact that only two species in the genus, which can grow at 37°C, are human pathogens. Species which have other virulence factors including capsule formation and melanisation, but lack the ability to propagate at 37°C are not pathogenic. In another related fungal pathogen, Candida albicans, heat shock protein 90 has been implicated to be a central player in commanding pathogenicity by governing yeast to hyphal transition and drug resistance...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28764795/participation-of-14-3-3%C3%AE%C2%B5-and-14-3-3%C3%AE-proteins-in-the-phagocytosis-component-of-cellular-immune-response-in-aedes-mosquito-cell-lines
#18
Abel Trujillo-Ocampo, Febe Elena Cázares-Raga, Rosa María Del Angel, Fernando Medina-Ramírez, Leopoldo Santos-Argumedo, Mario H Rodríguez, Fidel de la Cruz Hernández-Hernández
BACKGROUND: Better knowledge of the innate immune system of insects will improve our understanding of mosquitoes as potential vectors of diverse pathogens. The ubiquitously expressed 14-3-3 protein family is evolutionarily conserved from yeast to mammals, and at least two isoforms of 14-3-3, the ε and ζ, have been identified in insects. These proteins have been shown to participate in both humoral and cellular immune responses in Drosophila. As mosquitoes of the genus Aedes are the primary vectors for arboviruses, causing several diseases such as dengue fever, yellow fever, Zika and chikungunya fevers, cell lines derived from these mosquitoes, Aag-2 from Aedes aegypti and C6/36 HT from Aedes albopictus, are currently used to study the insect immune system...
August 1, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28763030/the-binding-effect-of-proteins-on-medications-and-its-impact-on-electrochemical-sensing-antipsychotic-clozapine-as-a-case-study
#19
George E Banis, Thomas Winkler, Patricia Barton, Sheryl E Chocron, Eunkyoung Kim, Deanna L Kelly, Gregory F Payne, Hadar Ben-Yoav, Reza Ghodssi
Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient's blood is critical for managing the patients' symptoms, side effects, and overall treatment efficacy. To that end, various electrochemical techniques have been adapted due to their capabilities in concentration-dependent sensing. An open question associated with electrochemical CLZ monitoring is whether drug-protein complexes (i...
August 1, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28755457/randomized-controlled-crossover-trial-of-prevention-of-clindamycin-induced-gastrointestinal-signs-using-a-synbiotic-in-healthy-research-cats
#20
J E Stokes, J M Price, J C Whittemore
BACKGROUND: Synbiotics often are prescribed to limit antibiotic-associated gastrointestinal signs (AAGS) in cats, but data to support this recommendation are lacking. OBJECTIVE: To determine whether synbiotic co-administration mitigates AAGS in healthy research cats treated with clindamycin. ANIMALS: 16 healthy research cats. METHODS: A randomized, double-blinded, placebo-controlled, 2-way, 2-period, crossover study with a 6-week washout was performed...
September 2017: Journal of Veterinary Internal Medicine
keyword
keyword
98378
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"