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eyes tumours

Darren Yap, Hannah Fox, Julia Addams-Williams
Neurofibroma is a slow growing benign tumour of the peripheral nerve sheath which is frequently associated with neurofibromatosis type 1 (Prakash et al., 2014). Isolated solitary occurrence of neurofibroma in the maxillary sinus is rare with only 29 reported cases in the literature. We present a rare case of a 70-year-old gentleman who was referred to ENT with a right maxillary sinus neurofibroma with extension into the right inferior orbit. He has significant proptosis, ptosis, and limitation in abduction of the right eye...
2016: Case Reports in Pathology
Ritva Heljasvaara, Mari Aikio, Heli Ruotsalainen, Taina Pihlajaniemi
Collagen XVIII is a ubiquitous basement membrane (BM) proteoglycan produced in three tissue-specific isoforms that differ in their N-terminal non-collagenous sequences, but share collagenous and C-terminal non-collagenous domains. The collagenous domain provides flexibility to the large collagen XVIII molecules on account of multiple interruptions in collagenous sequences. Each isoform has a complex multi-domain structure that endows it with an ability to perform various biological functions. The long isoform contains a frizzled-like (Fz) domain with Wnt-inhibiting activity and a unique domain of unknown function (DUF959), which is also present in the medium isoform...
October 13, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
Marina Marinkovic, Nanda Horeweg, Marta Fiocco, Femke P Peters, Linda W Sommers, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Gre P M Luyten, Carien L Creutzberg
PURPOSE: To evaluate efficacy and toxicity of two different protocols for eye-conserving treatment of patients with small to intermediate-sized choroidal melanomas; the current ruthenium-106 (Ru106) brachytherapy protocol and the preceding protocol of Ru106-brachytherapy with transpupillary thermotherapy (Ru106/TTT). METHODS AND MATERIALS: Long-term outcomes of 449 consecutive patients, of whom 196 (43.6%) treated using Ru106/TTT and 253 (56.3%) treated using Ru106, were compared in terms of local control, survival, eye preservation and visual outcome...
October 11, 2016: European Journal of Cancer
Jessica Mani Penny Tevaraj, Evelyn Tai Li Min, Raja Azmi Mohd Noor, Azhany Yaakub, Wan Hazabbah Wan Hitam
Neurofibromatosis type 2 usually presents with bilateral acoustic schwannomas. We highlight the rare presentation of neurofibromatosis initially involving third nerve. A 23-year-old Malay female presented with left eye drooping of the upper lid and limitation of upward movement for 8 years. It was associated with right-sided body weakness, change in voice, and hearing disturbance in the right ear for the past 2 years. On examination, there was mild ptosis and limitation of movement superiorly in the left eye...
2016: Case Reports in Ophthalmological Medicine
Amra Nadarevic Vodencarevic, Vahid Jusufovic, Svjetlana Terzic, Musfaha Burgic, Meliha Halibasic, Mersiha Sinanovic
AIM: Melanoma represents a malignant tumour arising from melanocytes. Uveal melanoma is the most common primary ocular malignancy among the adult population. The aim of the study was to examine epidemiological characteristics of ocular melanoma in University Clinic Centre in Tuzla, Bosnia and Herzegovina from January 2001 till November 2015. METHODS AND MATERIALS: In this retrospective study we used all available medical documentation to investigate the clinical findings which included age, gender, tumour size, histopathological features and the precise anatomic origin of the ocular melanoma...
July 24, 2016: Materia Socio-medica
D W Donnelly, A T Gavin
ABSTRACT: Whilst survival rates for childhood cancers are excellent, it is known that these patients have an increased risk of death from disease recurrence and other causes. We investigate patterns, trends and survival of cancers in children and young adults in N. Ireland. MATERIALS AND METHODS: 21 years (1993-2013) of cancer incidence data including non-malignant brain tumours from the N. Ireland Cancer Registry for persons aged 0-24 years was analysed using Joinpoint regresssion for trend and the Kaplan Meier method for survival analysis up to end 2013 with excess mortality calculated at one and five years after first cancer diagnosis using standardised mortality ratios...
September 2016: Ulster Medical Journal
Alexander V Tschulakow, Ulrich Schraermeyer, H Peter Rodemann, Sylvie Julien-Schraermeyer
Retinoblastoma (Rb) is the most frequent primary intraocular tumour in children and if let untreated, can cause death. Preclinical animal models that mimic molecular, genetic, and cellular features of cancers are essential for studying cancer and searching for promising diagnosis and treatment modalities. There are several models described for Rb, but none of them fully met our requirements.The aim of this study was to create a novel xenograft-nude mouse-model with broad application possibilities, which closely resembles the clinical observations and to investigate the development and spread of the tumour by using SLO/OCT as well as histology methods...
September 30, 2016: Biology Open
D Chuard, V Anthonipillai, R Dendale, C Nauraye, E Khan, C Mabit, L De Marzi, L Narici
Particle therapy provides an opportunity to study the human response to space radiation in ground-based facilities. On this basis, a study of light flashes analogous to astronauts' phosphenes reported by patients undergoing ocular proton therapy has been undertaken. The influence of treatment parameters on phosphene generation was investigated for 430 patients treated for a choroidal melanoma at the proton therapy centre of the Institut Curie (ICPO) in Orsay, France, between 2008 and 2011. 60% of them report light flashes, which are predominantly (74%) blue...
August 2016: Life Sciences in Space Research
P Justusová, M Štubňa, M Veselovský, B Lipková
INTRODUCTION: Uveal melanoma is the most common primary intraocular tumour in adults in Caucasians and in 75% is arising from choroid. It threatens not only the patients loss of vision and eye, but also 50% of patients after 5-year interval after therapy die due to distant metastases. The treatment of small and medium-sized melanoma are methods preserving eye globe. Almost half of the total number of patients is still unavoidable enucleation. Considerably rarer is indicated exenteration of an orbit...
2016: Ceská a Slovenská Oftalmologie
Melanie Schwermer, Sabine Dreesmann, Angelika Eggert, Kristina Althoff, Laura Steenpass, Alexander Schramm, Johannes H Schulte, Petra Temming
BACKGROUND: Retinoblastoma is the most common malignant cancer of the eye in children. While metastatic retinoblastoma is rare, cure rates for this advanced disease remain below 50%. High-level PLK1 expression in retinoblastomas has previously been shown to be correlated with adverse outcome parameters. PLK1 is a serine/threonine kinase involved in cell cycle regulation at the G2/M transition. PLK1 inhibition has been demonstrated to have anti-tumour effects in preclinical models of several paediatric tumours...
September 19, 2016: Clinical & Experimental Ophthalmology
Justo Aznar, Julio Tudela
BACKGROUND: The use of stem cells in regenerative medicine has major therapeutic potential. Recent clinical trials using cells derived from human stem cells are showing encouraging results, although these should be assessed with the necessary caution. DISCUSSION: Some media have reported the results of these trials without due care, perhaps creating expectations that do not match the reality of the facts. This paper describes some of the recent advances in the use of human stem cells, particularly those made in the area of ophthalmology, and more specifically, in Stargardt's disease and age-related macular degeneration (AMD)...
May 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
Aashrai Gudlavalleti, Ryan Dean, Yuxin Liu, Amit S Dhamoon
Sinonasal neuroendocrine tumours (NETs) are rare, aggressive neoplasms with a high recurrence potential. There are no robust protocols for the management of these tumours. An 81-year-old man presented with an incidental sinonasal mass visualised on CT scan of head. Over the next few weeks he developed new onset, progressively worsening headache, right eye ptosis and restricted extraocular movements. Imaging confirmed a rapidly enlarging tumour involving the right nasal cavity and the orbit. Biopsy showed a large cell neuroendocrine carcinoma of the right ethmoidal sinus...
2016: BMJ Case Reports
M Z Mahmoud, M Alkhorayef, A Sulieman
Objective: This study was designed with an aim to visualize the status of the posterior portion of the eye globe of adult Saudi cataract patients with brightness mode (B-mode) ultrasound, to find out any posterior segment lesions in such preoperative cases. Methods: A prospective study was performed between May 2014 and May 2015. A 375 pre-operative cataract (184, 49.1%) males and (191, 50.9%) females between the ages from 18 to 90 years; mean age of 54 ± 0.5 years were scanned at two Radiology Departments...
February 15, 2016: West Indian Medical Journal
Hemanshu Prabhakar, Gyaninder Pal Singh, Charu Mahajan, Indu Kapoor, Mani Kalaivani, Vidhu Anand
BACKGROUND: Brain tumour surgery usually is carried out with the patient under general anaesthesia. Over past years, both intravenous and inhalational anaesthetic agents have been used, but the superiority of one agent over the other is a topic of ongoing debate. Early and rapid emergence from anaesthesia is desirable for most neurosurgical patients. With the availability of newer intravenous and inhalational anaesthetic agents, all of which have inherent advantages and disadvantages, we remain uncertain as to which technique may result in more rapid early recovery from anaesthesia...
September 9, 2016: Cochrane Database of Systematic Reviews
Aaron Jamison, Kevin Crofts, Fiona Roberts, Maria Elena Gregory
This article reports a presentation of lacrimal sac rhinosporidiosis and informs the reader of this uncommon but important diagnosis. A 36-year-old man from Pakistan presented with a 3-month history of swelling at the nasal aspect of the left lower lid. This was associated with occasional crepitus and slight localised discomfort, but no epiphora. There was a palpable fullness near the left medial canthus associated with telecanthus but a normal sac washout and normal eye examination otherwise. Previous medical history included an ipsilateral nasal polypectomy and inferior meatal antrostomy around 10 years previously, whilst living in Pakistan...
October 2016: Orbit
Mojgan Padash Barmchi, Mary Gilbert, Miranda Thomas, Lawrence Banks, Bing Zhang, Vanessa J Auld
Cervical cancer is one of the leading causes of cancer death in women worldwide. The causative agents of cervical cancers, high-risk human papillomaviruses (HPVs), cause cancer through the action of two oncoproteins, E6 and E7. The E6 oncoprotein cooperates with an E3 ubiquitin ligase (UBE3A) to target the p53 tumour suppressor and important polarity and junctional PDZ proteins for proteasomal degradation, activities that are believed to contribute towards malignancy. However, the causative link between degradation of PDZ proteins and E6-mediated malignancy is largely unknown...
August 2016: PLoS Pathogens
Jiawei Wang, Francisco J Valiente-Soriano, Francisco M Nadal-Nicolás, Giuseppe Rovere, Shida Chen, Wenbin Huang, Marta Agudo-Barriuso, Jost B Jonas, Manuel Vidal-Sanz, Xiulan Zhang
PURPOSE: To analyse miRNA regulation in a rat model of acute ocular hypertension (AOH). METHODS: Acute ocular hypertension (AOH) was induced in the left eye of adult albino rats by inserting a cannula connected with a saline container into the anterior chamber. The contralateral eye served as a control. Seven days later, animals were killed. Retinas were used either for quantitative analysis of retinal ganglion cells (RGCs) and microglial cells or for miRNA array hybridization, qRT-PCR and Western blotting...
August 18, 2016: Acta Ophthalmologica
Zofia Michalewska, Janusz Michalewski, Jerzy Nawrocki
OBJECTIVE: The aim of this article is to report on retinal and choroidal morphology in choroidal nevi documented with Swept Source optical coherence tomography (SS-OCT). DESIGN: This is a retrospective, observational study. PARTICIPANTS: We included 27 consecutive patients with choroidal nevi. Mean age was 66.3 years (21-95 years). METHODS: The SS-OCT scanning protocol consisted of a single line scan through the centre of the nevi with a resolution of 3 µm, built from 1024 A-scans, with a length of 12 mm...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Lisa Koerver, Juliane Melzer, Eva Aguado Roca, Dominic Teichert, Timo Glatter, Eli Arama, Meike Broemer
De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cell survival, we identified the Drosophila ovarian tumour-type DUB DUBA (CG6091). DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye. Searching also for non-apoptotic functions of DUBA, we found that Duba-null mutants are male sterile and display defects in spermatid individualisation, a process that depends on non-apoptotic caspase activity...
August 12, 2016: Cell Death and Differentiation
Daniela Süsskind, José Hurst, Jens Martin Rohrbach, Sven Schnichels
BACKGROUND: To establish a mouse model with the aim of studying the tumour biology and metastasis formation of uveal melanoma. METHODS: Two human primary uveal melanoma cell lines (UMT2 and UMT42) were injected into the choroid of BALB/c nude mouse eyes. Intraocular tumour growth and metastasis formation in the liver and lungs were assessed after 13 to 22 weeks. Formalin-fixed, paraffin-embedded material was processed via haematoxylin and eosin staining for histological examination and periodic acid Schiff staining to search for extravascular matrix patterns...
August 9, 2016: Clinical & Experimental Ophthalmology
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