Line Ohm-Laursen, Hailong Meng, Kenneth B Hoehn, Nima Nouri, Yue Jiang, Chris Clouser, Timothy G Johnstone, Ron Hause, Balraj S Sandhar, Nadine E G Upton, Elfy B Chevretton, Raj Lakhani, Chris J Corrigan, Steven H Kleinstein, Hannah J Gould
In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal surfaces of the upper and lower respiratory tracts, and that their total antibody repertoire is modified in a common respiratory tract disease, in this case atopic asthma. Using Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) we have catalogued the antibody repertoires of B cell clones retrieved near contemporaneously from multiple sites in the upper and lower respiratory tract mucosa of adult volunteers with atopic asthma and non-atopic controls and traced their migration...
2021: Frontiers in Immunology