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ige antibodies in bronchial asthma

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https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#1
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27616735/estimation-of-serum-ykl-40-by-real-time-surface-plasmon-resonance-technology-in-north-indian-asthma-patients
#2
Sarla Naglot, Praveen Aggarwal, Sharmistha Dey, Krishna Dalal
BACKGROUND: Many studies reported for estimating serum YKL-40 using ELISA or RIA methods. This study introduces the plausible utilization of real-time surface plasmon resonance (SPR) technology in investigating the expression of serum YKL-40 protein levels and ELISA method for serum IgE in bronchial asthma. METHODS: A commercially available BIAcore 2000 instrument, based on SPR technology, was utilized for assessing serum YKL-40 levels in a control sample size of 45 and active sample size of 97...
September 12, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27608478/clinical-and-radiological-signs-of-abpa-associated-with-airways-infection-with-aspergillus-in-the-absence-of-specific-ige
#3
F Sunzini, C Barbato, C Canofari, L Lugari, R Perricone, A Bergamini
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus that mainly affects patients with asthma. For diagnosis, elevated serum IgE level are needed according to Greenberger and Patterson criteria. We report a case of 43 years-old woman who developed ABPA with productive cough, fever and radiological findings of multiple confluent areas of consolidation in both upper lobes. Laboratory tests showed elevated peripheral eosinophil counts (9.3 x 10(3)/ml). In bronchial washing A...
September 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27560910/-clinical-experience-with-omalizumab-in-patients-with-severe-asthma-real-world-data
#4
Jorge Bernardo Vargas-Correa, Raúl Bracamonte-Peraza, Sylvia Marcela Espinosa-Morales, Francisco Vázquez-Nava
BACKGROUND: Omalizumab is a monoclonal antibody that is prescribed in a stepwise addition regimen for the treatment of severe asthma. OBJECTIVE: To report the experience of patients with severe asthma who were given omalizumab in accordance with international guides, in a context of real-world data. METHODS: Open, analytical, cross-sectional, retrospective, observational clinical study with real-world data. GINA 2006 Asthma Control Scheme was used to evaluate patients, and a questionnaire was used to evaluate patient characteristics, effectiveness, safety, and tolerance to omalizumab...
July 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27477800/low-grade-disease-activity-in-early-life-precedes-childhood-asthma-and-allergy
#5
Bo Lund Krogsgaard Chawes
Asthma and allergies are today the most common chronic diseases in children and the leading causes of school absences, chronic medication usage, emergency department visits and hospitalizations, which affect all members of the family and represent a significant societal and scientific challenge. These highly prevalent disorders are thought to originate from immune distortion in early childhood, but the etiology and heterogeneity of the disease mechanisms are not understood, which hampers preventive initiatives and makes treatment inadequate...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27435350/the-effect-of-omalizumab-on-eosinophilic-inflammation-of-the-respiratory-tract-in-patients-with-allergic-asthma
#6
Izabela Kupryś-Lipińska, Katarzyna Molińska, Piotr Kuna
Bronchial asthma is characterised by high levels of immunoglobulin E (IgE) and overproduction of pro-inflammatory cytokines, including interleukins IL-4, IL-13 and IL-5 needed for, amongst other things, the production of IgE and the differentiation, maturation, migration and survival of eosinophils. Eosinophils are one of the most important cells in allergic inflammation. Their presence in tissue is linked to the persistence of inflammatory infiltrate, tissue damage and remodelling. Although these cells are very sensitive to corticosteroids, some asthmatic patients do not respond to high doses of these drugs, even when administered systemically...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27249439/sensitization-pattern-and-clinical-pecularities-of-food-allergy-in-georgia
#7
N Lomidze, T Abramidze, T Gotua, N Dolidze, M Gotua
The aim of our study was to investigate sensitization pattern to food allergens in different age groups of atopic patients in Georgia and reveal the associations between food sensitization and clinical manifestations of allergic disease reflecting the development of atopic march. 1000 patients (children-783, adult-217) with different clinical manifestations were involved in the study. Specific IgE antibodies to food mix, cow's milk, casein, egg, wheat, fish, nuts mixture and inhalant allergens were measured by using ImmunoCap (Phadia, Uppsala, Sweden)...
April 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27230825/bronchial-thermoplasty-and-biological-therapy-as-targeted-treatments-for-severe-uncontrolled-asthma
#8
REVIEW
Abhaya Trivedi, Ian D Pavord, Mario Castro
Although a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major advancement in the management of severe asthma. Omalizumab, a monoclonal antibody to IgE, improves asthma control in patients with a predominant allergic phenotype. Monoclonal antibodies targeted to interleukin 4α and interleukin 5 have shown substantial benefit in patients with the eosinophilic asthma phenotype; so too have monoclonal antibodies targeted to interleukin 13 in patients with a type 2 allergic phenotype...
July 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27187333/quercetin-and-its-anti-allergic-immune-response
#9
REVIEW
Jiri Mlcek, Tunde Jurikova, Sona Skrovankova, Jiri Sochor
Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, and grapes); some herbs; tea; and wine. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26693131/late-onset-aspergillus-fumigatus-infection-of-an-aortic-stent-graft-in-an-immunocompetent-patient
#10
Fatos Ballazhi, Michael Weyand, Werner Lang, Christoph Schoerner, Timo Seitz
Aspergillus fumigatus as a clinical entity is difficult to diagnose. We present a case, which could facilitate diagnosis and management of the aforementioned disease. A 60-year-old man with stent graft implantation in the descending aorta (6 years ago) presented with fever, night sweats, and weight loss over 5 months. Leukocytosis and elevated C-reactive protein were constantly spiking. Blood cultures were negative. Notably, the serum immunoglobulin E (IgE) level was strongly elevated (> 1,000 U/mL). Anamnestically, the patient suffered from a mild form of atopic dermatitis and bronchial asthma...
December 2015: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/26621973/anti-ige-treatment-airway-inflammation-and-remodelling-in-severe-allergic-asthma-current-knowledge-and-future-perspectives
#11
REVIEW
Konstantinos Samitas, Vasiliki Delimpoura, Eleftherios Zervas, Mina Gaga
Asthma is a disorder of the airways involving various inflammatory cells and mediators and characterised by bronchial hyperresponsiveness, chronic inflammation and structural alterations in the airways, also known as remodelling. IgE is an important mediator of allergic reactions and has a central role in allergic asthma pathophysiology, as it is implicated in both the early and late phase allergic response. Moreover, clinical and mechanistic evidence has lately emerged, implicating IgE in the development of airway remodelling...
December 2015: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/26610050/new-data-analysis-in-a-population-study-raises-the-hypothesis-that-particle-size-contributes-to-the-pro-asthmatic-potential-of-small-pet-animal-allergens
#12
Antonios Patelis, Amrita Dosanjh, Maria Gunnbjörnsdottir, Magnus P Borres, Marieann Högman, Kjell Alving, Christer Janson, Andrei Malinovschi
BACKGROUND: The size of inhaled particles influences where they deposit and theoretically should be important for the development of airway inflammation and responsiveness. Our aim was to assess if sensitization to smaller-sized aeroallergens relates to higher prevalence of treated asthma, increased airway responsiveness, and airway and systemic inflammation. METHODS: Molecular-based IgE antibody determination was done in 467 subjects. Sensitized subjects were grouped based on the particle size of the aeroallergen: (1) Large particles only (mainly pollen); (2) Medium-sized particles (sensitized to mainly mite and mold and possibly to large particles); and 3) Small particles (sensitized to pet allergens and possibly to medium- and/or large-sized particles)...
2016: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/26528362/approach-to-patients-with-severe-asthma-a-consensus-statement-from-the-respiratory-care-experts-input-forum-rc-eif-iran
#13
REVIEW
Khalil Ansarin, Davood Attaran, Hamidreza Jamaati, Mohammad Reza Masjedi, Hamidreza Abtahi, Ali Alavi, Masoud Aliyali, Amir Mohammad Hashem Asnaashari, Reza Farid-Hosseini, Seyyed Mohammad Ali Ghayumi, Hassan Ghobadi, Atabak Ghotb, Abolhassan Halvani, Abbas Nemati, Mohammad Hossein Rahimi Rad, Masoud Rahimian, Ramin Sami, Hamid Sohrabpour, Sasan Tavana, Mohammad Torabi-Nami, Parviz Vahedi
Challenges in the assessment, diagnosis and management of severe, difficult-to-control asthma are increasingly regarded as clinical needs yet unmet. The assessments required to determine asthma severity, comorbidities and confounding factors, disease phenotypes and optimal treatment are among the controversial issues in the field. The respiratory care experts' input forum (RC-EIF), comprised of an Iranian panel of experts, reviewed the definition, appraised the available guidelines and provided a consensus for evaluation and treatment of severe asthma in adults...
2015: Tanaffos
https://www.readbyqxmd.com/read/26466493/-preoperative-management-of-patients-with-bronchial-asthma-or-chronic-bronchitis
#14
Satoshi Hagihira
Bronchial asthma is characterized by chronic airway inflammation. The primary goal of treatment of asthma is to maintain the state of control. According to the Japanese guidelines (JGL2012), long-term management consists of 4 therapeutic steps, and use of inhaled corticosteroids (ICS) is recommended at all 4 steps. Besides ICS, inhalation of long-acting β2-agonist (LABA) is also effective. Recently, omalizumab (a humanized antihuman IgE antibody) can be available for patients with severe allergic asthma. Although there is no specific strategy for preoperative treatment of patients with asthma, preoperative systemic steroid administration seemed to be effective to prevent asthma attack during anesthesia...
September 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26304475/assessment-of-the-mechanistic-role-of-cinnarizine-in-modulating-experimentally-induced-bronchial-asthma-in-rats
#15
Maha M Abdel-Fattah, Basim A S Messiha, Abeer A A Salama
BACKGROUND/AIMS: Calcium influx, inflammatory infiltration, cytokine production, immunoglobulin E activation and oxidative stress play coordinated roles in bronchial asthma pathogenesis. We aim to assess the protective effect of cinnarizine against experimentally induced bronchial asthma. METHODS: Bronchial asthma was induced by ovalbumin sensitization and challenge. Rats were allocated into a normal control, an asthma control, a dexamethasone (standard) treatment, and 2 cinnarizine treatment groups...
2015: Pharmacology
https://www.readbyqxmd.com/read/26155158/additive-anti-allergic-effects-of-anti-interleukin-33-and-anti-siglec-f-treatments-in-a-murine-model-of-allergic-asthma
#16
Tae Young Jang, Chang-Shin Park, Myung-Shin Jeon, Min-Jeong Heo, Kwangmin Na, Young Hyo Kim
BACKGROUND: Anti-interleukin-33 (anti-IL-33) and anti-Siglec-F antibodies have potent anti-allergic effects on murine allergic asthma and rhinitis and induce eosinophil apoptosis. OBJECTIVE: We aimed to determine whether post-sensitization with anti-IL-33/anti-Siglec-F treatments exhibited more potent effects compared to individual treatments in a murine allergic asthma model. MATERIAL AND METHODS: Twenty-five BALB/c mice were separated into five groups (n = 5): Group A (control), Group B (ovalbumin [OVA] challenge), Group C (OVA + anti-IL-33), Group D (OVA + anti-Siglec-F), and Group E (OVA + anti-IL-33 + anti-Siglec-F)...
2014: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26124850/case-of-seropositive-allergic-bronchopulmonary-aspergillosis-in-a-10-year-old-girl-without-previously-documented-asthma
#17
Jeong Eun Shin, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was referred to the Department of Pediatric Pulmonology for persistent consolidations on chest radiography. Pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with a 4-week prescription of broad-spectrum antibiotics. The patient had a history of atopic dermatitis and allergic rhinitis but no history of asthma...
May 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26120539/guideline-on-allergen-specific-immunotherapy-in-ige-mediated-allergic-diseases-s2k-guideline-of-the-german-society-for-allergology-and-clinical-immunology-dgaki-the-society-for-pediatric-allergy-and-environmental-medicine-gpa-the-medical-association-of-german
#18
Oliver Pfaar, Claus Bachert, Albrecht Bufe, Roland Buhl, Christof Ebner, Peter Eng, Frank Friedrichs, Thomas Fuchs, Eckard Hamelmann, Doris Hartwig-Bade, Thomas Hering, Isidor Huttegger, Kirsten Jung, Ludger Klimek, Matthias Volkmar Kopp, Hans Merk, Uta Rabe, Joachim Saloga, Peter Schmid-Grendelmeier, Antje Schuster, Nicolaus Schwerk, Helmut Sitter, Ulrich Umpfenbach, Bettina Wedi, Stefan Wöhrl, Margitta Worm, Jörg Kleine-Tebbe, Susanne Kaul, Anja Schwalfenberg
The present guideline (S2k) on allergen-specific immunotherapy (AIT) was established by the German, Austrian and Swiss professional associations for allergy in consensus with the scientific specialist societies and professional associations in the fields of otolaryngology, dermatology and venereology, pediatric and adolescent medicine, pneumology as well as a German patient organization (German Allergy and Asthma Association; Deutscher Allergie- und Asthmabund, DAAB) according to the criteria of the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF)...
2014: Allergo Journal International
https://www.readbyqxmd.com/read/26120534/bronchial-asthma-is-personalized-therapy-on-the-horizon
#19
Christian Taube
In the last years there is an increasing trend towards personalized medicine for patients with asthma. This is due to the availability of novel specific therapies. These new compounds are supposed to be used in well-defined patient groups, which are likely to respond to these interventions. In addition to already used anti-IgE, novel monoclonal antibodies such as anti-IL-5 and anti-IL-13 are becoming available. Currently clinical trials are ongoing to identify which patient population will respond to these novel therapies...
2014: Allergo Journal International
https://www.readbyqxmd.com/read/26006019/bronchial-lesions-of-mouse-model-of-asthma-are-preceded-by-immune-complex-vasculitis-and-induced-bronchial-associated-lymphoid-tissue-ibalt
#20
Ian C Guest, Stewart Sell
We systematically examined by immune histology the lungs of some widely used mouse models of asthma. These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal or aerosol challenges 3 days apart. Within 24 h after a single challenge there is fibrinoid necrosis of arterial walls with deposition of immunoglobulin (Ig) and OVA and infiltration of eosinophilic polymorphonuclear cells that lasts for about 3 days followed by peribronchial B-cell infiltration and slight reversible goblet cell hypertrophy (GCHT)...
August 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
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