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https://www.readbyqxmd.com/read/29773421/r46l-polymorphism-in-the-pcsk9-gene-relationship-to-lipid-levels-subclinical-vascular-disease-and-erectile-dysfunction
#1
Jose M Mostaza, Carlos Lahoz, Miguel A Salinero-Fort, Olaya de Dios, Elisa Castillo, Teresa González-Alegre, Francisca García-Iglesias, Eva Estirado, Fernando Laguna, Concesa Sabín, Silvia López, Victor Cornejo, Carmen de Burgos, Vanesa Sanchez, Carmen Garcés
BACKGROUND: The R46L variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been related to lipid levels and cardiovascular disease. OBJECTIVE: To evaluate the influence of this polymorphism on subclinical vascular disease and erectile dysfunction (ED). METHODS: We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness (IMT), and the ankle-brachial index, in 1188 adults free of cardiovascular disease, randomly selected from the population...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29770768/treatment-of-femoro-popliteal-lesions-with-scoring-and-drug-coated-balloon-angioplasty-12-month-results-of-the-dcb-trak-registry
#2
Magnus Baumhäkel, Shalva Chkhetia, Michael Kindermann
PURPOSE: Debulking strategies prior to drug-coated balloon (DCB) angioplasty were suggested to improve clinical results in femoro-popliteal lesions. Currently, there are no data regarding plaque modification with a scoring balloon with subsequent DCB-angioplasty. Recently published 6-month results of the DCB-Trak registry in patients treated with scoring-balloon angioplasty and DCB-angioplasty were promising without any safety concerns. Herein, we report the 12-month follow-up data. METHODS: In a single center registry, 29 consecutive patients with 32 femoro-popliteal lesions were treated with a scoring-balloon (VascuTrak®) and a DCB subsequently...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29769764/association-of-pentraxin-and-high-sensitive-c-reactive-protein-as-inflammatory-biomarkers-in-patients-with-chronic-periodontitis-and-peripheral-arterial-disease
#3
Ramanarayana Boyapati, Srikanth Chinthalapani, Arpita Ramisetti, Shyam Sunder Salavadhi, Radhika Ramachandran
Context: Inflammation is a common feature of both peripheral artery disease (PAD) and periodontal disease. Aim: The aim of this study is to evaluate the relationship between PAD and periodontal disease by examining the levels of inflammatory cytokines, pentraxin-3 (PTX-3), and high-sensitive C-reactive protein from serum. Materials and Methods: A total of 50 patients were included in this cross-sectional study. Patients were divided into two groups: those with PAD (test group) and those with the non-PAD group (control group) based on ankle-brachial index values...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29768290/intense-aerobic-exercise-lowers-blood-pressure-in-individuals-with-metabolic-syndrome-taking-antihypertensive-medicine
#4
Miguel Ramirez-Jimenez, Valentin Fernandez-Elias, Felix Morales-Palomo, Juan F Ortega, Ricardo Mora-Rodriguez
OBJECTIVE: There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise. PARTICIPANTS AND METHODS: Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order...
May 15, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29768162/-structural-and-functional-changes-of-blood-vessels-in-women-in-early-postmenopause-the-possibility-of-correction-of-the-revealed-violations
#5
S N Tolstov, I A Salov, A P Rebrov
AIM: To evaluate severity and pattern of structural and functional changes of vascular wall in early postmenopausal women receiving chronic treatment with a low-dose combination of 17β-estradiol (E2) 1 mg and drospirenone 2 mg (DRSP). Evaluation of structural and functional arterial remodeling might be important for assessment of cardiovascular risk in postmenopausal women. MATERIALS AND METHODS: The study included 162 early postmenopausal women with postmenopausal syndrome...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29766282/parameters-of-pulse-wave-velocity-determinants-and-reference-values-assessed-in-the-population-based-study-life-adult
#6
Daniel Baier, Andrej Teren, Kerstin Wirkner, Markus Loeffler, Markus Scholz
AIMS AND BACKGROUND: Parameters of arterial stiffness such as pulse wave velocity (PWV) were recently proposed as independent risk factors of cardiovascular events. We analyse three PWV parameters in the large population-based study LIFE-Adult to identify risk factors, normal and reference values. METHODS AND RESULTS: Brachial-ankle (ba), brachial-femoral (bf) and carotid-femoral (cf) PWV assessment was performed using Vicorder device. 8509 participants aged 19-80 were analysed...
May 15, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29765328/long-term-consumption-of-cuban-policosanol-lowers-central-and-brachial-blood-pressure-and-improves-lipid-profile-with-enhancement-of-lipoprotein-properties-in-healthy-korean-participants
#7
Suk-Jeong Kim, Dhananjay Yadav, Hye-Jeong Park, Jae-Ryong Kim, Kyung-Hyun Cho
Metabolic syndrome is closely associated with higher risk of hypertension, cardiovascular disease (CVD), diabetes and stroke. The aim of the present study was to investigate the long-term effects of policosanol supplementation on blood pressure (BP) and the lipid profile in healthy Korean participants with pre-hypertension (systolic 120-139 mmHg, diastolic 85-89 mmHg). This randomized, double-blinded, and placebo-controlled trial included 84 healthy participants who were randomly assigned to three groups receiving 10 mg of policosanol, 20 mg of policosanol, or placebo for 24 weeks...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29763373/oral-glucose-challenge-impairs-skeletal-muscle-microvascular-blood-flow-in-healthy-people
#8
Ryan D Russell, Donghua Hu, Timothy Greenaway, James E Sharman, Stephen Rattigan, Stephen M Richards, Michelle A Keske
Skeletal muscle microvascular (capillary) blood flow increases in the post-prandial state or during insulin infusion due to dilation of pre-capillary arterioles to augment glucose disposal. This effect occurs independent of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict pre-capillary arterioles, and causes muscle insulin resistance in vivo. We hypothesize that acute hyperglycemia impairs post-prandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761317/high-sodium-intake-and-sodium-to-potassium-ratio-may-be-linked-to-subsequent-increase-in-vascular-damage-in-adults-aged-40-years-and-older-the-korean-multi-rural-communities-cohort-mrcohort
#9
Sukyoung Jung, Mi Kyung Kim, Jinho Shin, Bo Youl Choi, Young-Hoon Lee, Dong Hoon Shin, Min-Ho Shin
PURPOSE: Subclinical vascular damage is a chronic intermediate process in cardiovascular disease (CVD) and high sodium (Na) has been regarded as an adverse factor in subclinical vascular health; however, the longitudinal relationship between Na intake and subclinical vascular damage has not been studied. We aimed to evaluate the longitudinal relationship of dietary Na intake and sodium to potassium ratio (Na:K) with brachial-ankle pulse wave velocity (baPWV) and carotid intima media thickness (cIMT) in healthy adults aged 40 years and older in Korea...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29761091/increase-in-the-arterial-velocity-pulse-index-of-patients-with-peripheral-artery-disease
#10
Naotaka Murata, Kazuki Shiina, Jun Yamashita, Nobuhiro Tanaka, Taishiro Chikamori, Akira Yamashina, Hirofumi Tomiyama
Background: Recently, a simple parameter calculated from the brachial pressure waveform recorded using an oscillometric device (arterial velocity pulse index [AVI]: ratio of the forward/reflected pressure wave amplitudes) has become available to assess the pathophysiological abnormalities associated with vascular damage. Peripheral artery disease (PAD) represents one of the disease entities associated with the advanced stages of atherosclerotic vascular damage. The present study was conducted to examine whether an increase in the AVI might be influenced by the presence of PAD...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29761086/aortic-brachial-pulse-wave-velocity-ratio-a-measure-of-arterial-stiffness-gradient-not-affected-by-mean-arterial-pressure
#11
REVIEW
Catherine Fortier, Marie-Pier Desjardins, Mohsen Agharazii
Background: Aortic stiffness, measured by carotid-femoral pulse wave velocity (cf-PWV), is used for the prediction of cardiovascular risk. This mini-review describes the nonlinear relationship between cf-PWV and operational blood pressure, presents the proposed methods to adjust for this relationship, and discusses a potential place for aortic-brachial PWV ratio (a measure of arterial stiffness gradient) as a blood pressure-independent measure of vascular aging. Summary: PWV is inherently dependent on the operational blood pressure...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29761083/lower-heart-rate-variability-is-associated-with-lower-pulse-pressure-amplification-role-of-obesity
#12
Nicola Di Daniele, Manfredi Tesauro, Alberto Mascali, Valentina Rovella, Angelo Scuteri
Background: Heart rate variability (HRV), pulse pressure amplification, and obesity represent risk factors for cardiovascular events. The aims of the present study are (1) to explore the impact of HRV on pulse pressure amplification and (2) to investigate whether the association between HRV and pulse pressure amplification differs in obese and lean subjects. Methods: A total of 342 patients (age 61 ± 11 years) were enrolled. HRV was analyzed concerning both the frequency and time domain as well as concerning the HRV triangular index...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29760461/arterial-stiffness-not-systolic-blood-pressure-increases-with-age-in-native-papuan-populations
#13
Akio Ishida, Michiko Fujisawa, Eva Garcia Del Saz, Kiyohito Okumiya, Yumi Kimura, Indrajaya Ida Bagus Manuaba, Marthen Ferry Kareth, Andreas Lallo Rantetampang, Yusuke Ohya, Kozo Matsubayashi
Systolic blood pressure (SBP) and arterial stiffness are closely related and may behave reciprocally as cause or effect, interacting in a vicious cycle. Both SBP and arterial stiffness increase with age in populations in most developed countries. However, the age-related increase in SBP appears to be absent in indigenous populations, partially because of their lifelong low-sodium and high-potassium diets, whereas age-related arterial stiffening in these populations remains to be determined. We performed a field survey of the indigenous population of Soroba, a small village located in the central highlands of Papua, Indonesia...
May 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29756465/hand-use-at-home-questionnaire-validity-and-reliability-in-children-with-neonatal-brachial-plexus-palsy-or-unilateral-cerebral-palsy
#14
Menno van der Holst, Yvonne Geerdink, Pauline Aarts, Duco Steenbeek, Willem Pondaag, Rob Ghh Nelissen, Alexander Ch Geurts, Thea Pm Vliet Vlieland
OBJECTIVE: To investigate construct validity and test-retest reliability of the parent-rated Hand-Use-at-Home questionnaire (HUH) in children with neonatal brachial plexus palsy or unilateral cerebral palsy. DESIGN AND SUBJECTS: For this cross-sectional study, children with neonatal brachial plexus palsy or unilateral cerebral palsy, aged 3-10 years, were eligible. MAIN MEASURES: The HUH, Pediatric Outcome Data Collection Instrument Upper Extremity Scale (neonatal brachial plexus palsy only), and Children's Hand-Use Experience Questionnaire (unilateral cerebral palsy only) were completed...
May 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29754930/new-assessment-of-endothelial-function-measured-by-short-time-flow-mediated-vasodilation-comparison-with-conventional-flow-mediated-vasodilation-measurement
#15
Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Haruki Hashimoto, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Farina Mohamad Yusoff, Shinji Kishimoto, Ayumu Nakashima, Kensuke Noma, Tomohiro Kawaguchi, Takeo Matsumoto, Yukihito Higashi
BACKGROUND: Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interventions and cardiovascular events. To shorten and simplify the measurement of FMD, we have developed a novel technique named short time FMD (stFMD). We investigated the validity of stFMD for assessment of endothelial function compared with conventional FMD...
May 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754863/relationships-of-anxiety-and-depression-with-cardiovascular-health-in-youth-with-normal-weight-to-severe-obesity
#16
Amy C Gross, Alexander M Kaizer, Justin R Ryder, Claudia K Fox, Kyle D Rudser, Donald R Dengel, Aaron S Kelly
OBJECTIVE: To evaluate the relationships of depression and anxiety symptoms with cardiovascular disease (CVD) risk factors and measures of vascular health in youth. Major depressive disorder and bipolar disorder are considered CVD risk factors in youth. STUDY DESIGN: Participants (n = 202) were 8- to 18-year-olds from a cross-sectional study evaluating cardiovascular health across a wide range of body mass index values (normal weight to severe obesity). CVD risk measurement included blood pressure, fasting lipids, glucose, insulin, carotid artery intima-media thickness, compliance and distensibility, brachial artery flow-mediated dilation, carotid-radial artery pulse wave velocity, body fat percentage, and a metabolic syndrome cluster score...
May 10, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29754460/prognostic-evaluation-of-the-elastic-properties-of-the-ascending-aorta-in-dilated-cardiomyopathy
#17
Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Davide Fabbricatore, Francesco Prati, Mattia Pagnoni, Marco Metra
BACKGROUND: Nowadays there is an increased interest in the role of aortic stiffness in the pathophysiology of heart failure (HF), since it is a major determinant of left ventricular (LV) performance. We aimed at assessing the predictive value of the aortic stiffness parameters, measured by echocardiography, in patients affected by non-ischemic dilated cardiomyopathy (DCM) regarding three end-points: death, HF rehospitalization, combined death or HF rehospitalization in a long-term follow-up...
May 13, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29754137/unusual-cause-of-brachial-palsy-with-diaphragmatic-palsy
#18
Vishal Gupta, Aakash Pandita, Astha Panghal, Neha Hassan
We report a preterm neonate born with respiratory distress. The neonate was found to have diaphragmatic palsy and brachial palsy. The neonate was born by caesarean section and there was no history of birth trauma. On examination, there was bilateral congenital talipes equinovarus and a scar was present on the forearm. The mother had a history of chickenpox during the 16 weeks of pregnancy for which no treatment was sought. On investigation, PCR for varicella was found to be positive in the neonate.
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29751719/-panax-notoginseng-extract-combined-with-alprostadil-in-treatment-of-arteriosclerosis-obliterans-meta-analysis
#19
(no author information available yet)
To evaluate the clinical efficacy of Panax notoginseng extract combined with alprostadil in the treatment of arteriosclerosis occlusion and investigate its effects on the degree of atherosclerosis. CNKI, Wanfang, VIP journal database, Chinese biomedical literature database(CBM), PubMed, the Cochrane Library and Science Citation Index(SCI) database were searched between inception to December 2017 for relevant studies. Two researchers independently screened and extracted the literature in strict accordance with the inclusion criteria and exclusion criteria...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29749701/the-relationship-of-renal-function-to-segmental-vascular-stiffness-ankle-brachial-index-and-peripheral-artery-disease
#20
Yueh-Hung Lin, Kuo-Tzu Sung, Cheng-Ting Tsai, Pei-Chen Wu, Yau-Huei Lai, Chi-In Lo, Fa-Chang Yu, Hsu-Ping Wu, Wei-Ran Lan, Jen-Yuan Kuo, Charles Jia-Yin Hou, Chi-Hsuan Yen, Ming-Cheng Peng, Ta-Chuan Hung, Chung-Lieh Hung, Edward Lai, Hung-I Yeh
The authors consecutively assessed various arterial pulse-wave velocity (PWV) indices and ankle-brachial index (ABI) by an automatic device (VP2000, OMRON Health Care Co. Ltd., Kyota, Japan) in outpatients with ≥ 1 cardiovascular risk. PAD was defined as ABI ≤ 0.9. Among 2309 outpatients (mean age 62.4 years), worse renal function was associated with higher brachial-ankle PWV, heart-carotid PWV, heart-femoral PWV (hf-PWV), and lower ABI (all P < .001). Multivariate regression models showed independent associations between lower eGFR, lower ABI (Coef: 0...
May 11, 2018: Journal of Clinical Hypertension
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