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intrauterine adhesions

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https://www.readbyqxmd.com/read/29203342/effect-of-early-second-look-hysteroscopy-on-reproductive-outcomes-after-hysteroscopic-adhesiolysis-in-patients-with-intrauterine-adhesion-a-retrospective-study-in-china
#1
Wenzhi Xu, Yuxue Zhang, Yang Yang, Songying Zhang, Xiaona Lin
OBJECTIVE: The aim of this study was to assess the effect of early second-look hysteroscopy after hysteroscopic adhesiolysis for intrauterine adhesions (IUAs) on the pregnancy rate (PR) and live birth rate (LBR). STUDY DESIGN: It is a retrospective, observational study of 151 women were referred to our institution from January 2010 to January 2016. Operative hysteroscopy for treatment of IUAs and office hysteroscopic follow-up to assess IUAs. We investigated demographic characteristics, menstrual pattern, previous intrauterine surgery, reproductive history, ovarian preservation assessment, tubal patency examination, husband's semen test, obstetric parameters, and surgical variables to evaluate the effect of early second-look hysteroscopy after hysteroscopic adhesiolysis on the PR and LBR...
December 1, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29196267/intrauterine-exosomes-are-required-for-bovine-conceptus-implantation
#2
Kazuya Kusama, Keigo Nakamura, Rulan Bai, Kentaro Nagaoka, Toshihiro Sakurai, Kazuhiko Imakawa
Exosomes, extracellular vesicles, are present in uterine flushing fluids (UFs), which are involved in conceptus-endometrial interactions during peri-implantation periods. Despite several studies on intrauterine exosomes conducted, the roles conceptus and endometrial exosomes play during peri-implantation periods have not been well characterized. To investigate the effect of bovine intrauterine exosomes on conceptus implantation, exosomes isolated from bovine UFs during peri-implantation periods were subjected to global protein analysis...
November 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29178172/anti-adhesion-therapy-following-operative-hysteroscopy-for-treatment-of-female-subfertility
#3
REVIEW
Jan Bosteels, Steven Weyers, Thomas M D'Hooghe, Helen Torrance, Frank J Broekmans, Su Jen Chua, Ben Willem J Mol
BACKGROUND: Observational evidence suggests a potential benefit with several anti-adhesion therapies in women undergoing operative hysteroscopy (e.g. insertion of an intrauterine device or balloon, hormonal treatment, barrier gels or human amniotic membrane grafting) for decreasing intrauterine adhesions (IUAs). OBJECTIVES: To assess the effectiveness of anti-adhesion therapies versus placebo, no treatment or any other anti-adhesion therapy, following operative hysteroscopy for treatment of female subfertility...
November 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29157289/vitamin-c-plus-hydrogel-facilitates-bone-marrow-stromal-cell-mediated-endometrium-regeneration-in-rats
#4
Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu, Yuqing Chen
BACKGROUND: Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drugs appears disappointing, cell therapy has emerged as an alternative choice for endometrium regeneration. The aim of this study is to investigate whether the combination of hydrogel Pluronic F-127 (PF-127), Vitamin C (Vc), and a bone marrow stromal cell (BMSC) mixture could be a feasible strategy to improve the endometrial regeneration in a mechanical damage model of IUA in rats...
November 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#5
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29133764/advanced-role-of-hippo-signaling-in-endometrial-fibrosis-implications-for-intrauterine-adhesion
#6
REVIEW
Hai-Yan Zhu, Tian-Xiang Ge, Yi-Bin Pan, Song-Ying Zhang
OBJECTIVE: Intrauterine adhesion (IUA) is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-β (TGF-β) signaling pathways to form an intricate network governing the development of fibrosis...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#7
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/29038040/hysteroscopic-intrauterine-adhesiolysis-using-a-blunt-spreading-dissection-technique-with-a-double-action-forceps
#8
Huan Huang, Chunxia Cheng, Grace Johnson, Ruoyi Wang, Min Xue, Aiqian Zhang, Dabao Xu, Xiaoming Guan
STUDY OBJECTIVE: To demonstrate step by step the technique of hysteroscopic adhesiolysis (HA) by means of a blunt spreading technique using double action forceps to dissect and restore the layer between the anterior and posterior uterine walls in a patient with severe intrauterine adhesions (IUA), particularly in cases in which the endometrial lining is obscured on ultrasound imaging and the endometrial cavity is completely occluded on hysteroscopy. DESIGN: Step-by-step explanation of the technique using videos and pictures (educative video) (Canadian Task Force Classification III)...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29026991/trichomonas-vaginalis-clinical-isolates-cytoadherence-and-adherence-to-polystyrene-intrauterine-device-and-vaginal-ring
#9
Odelta Dos Santos, Graziela Vargas Rigo, Alexandre José Macedo, Tiana Tasca
The parasitism by Trichomonas vaginalis is complex and in part is mediated by cytoadherence accomplished via five surface proteins named adhesins and a glycoconjugate called lipophosphoglycan (TvLPG). In this study, we evaluated the ability of T. vaginalis isolates to adhere to cells, plastic (polystyrene microplates), intrauterine device (IUD), and vaginal ring. Of 32 T. vaginalis isolates, 4 (12.5%) were strong adherent. The T. vaginalis isolates TV-LACM6 and TV-LACM14 (strong polystyrene-adherent) were also able to adhere to IUD and vaginal ring...
December 2017: Parasitology Research
https://www.readbyqxmd.com/read/29024798/hysteroscopic-management-of-asherman-s-syndrome-special-issue-report-on-uterine-surgery-in-the-journal-of-minimally-invasive-gynecology
#10
Zaraq Khan, Jeffrey M Goldberg
In developed countries, Asherman's Syndrome is almost always the result of a prior intrauterine operative trauma. This is often asymptomatic but may result in hypo- or amenorrhea and can contribute to infertility and pregnancy complications. We will review their etiology, clinical implications, and the systems which have been proposed to classify their extent. The numerous methods reported for performing lysis of intrauterine adhesions will be summarized along with the clinical results. Current strategies to prevent recurrence of intrauterine adhesions have not been conclusively shown to be clinically effective but the potential for endometrial regeneration using stem cells is an exciting modality under investigation...
October 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28972429/assessment-of-risk-factors-of-intrauterine-adhesions-in-patients-with-induced-abortion-and-the-curative-effect-of-hysteroscopic-surgery
#11
Xiaoliang Mo, Guirong Qin, Zhoulin Zhou, Xiaoli Jiang
OBJECTIVE: To explore the risk factors for intrauterine adhesions in patients with artificial abortion and clinical efficacy of hysteroscopic dissection. METHODS: 1500 patients undergoing artificial abortion between January 2014 and June 2015 were enrolled into this study. The patients were divided into two groups with or without intrauterine adhesions. Univariate and Multiple logistic regression were conducted to assess the effects of multiple factors on the development of intrauterine adhesions following induced abortion...
October 3, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28939480/hysteroscopic-removal-of-retained-products-of-conception-implanted-over-a-focal-area-of-adenomyosis-a-case-report
#12
Luis Alonso, Laura Nieto, Jose Carugno
STUDY OBJECTIVE: To describe a technique for hysteroscopic removal of retained products of conception (RPOC) implanted over an area of adenomyosis. DESIGN: A case report (Canadian Task Force classification III). SETTING: RPOC is an unfortunate complication that may occur after the resolution of a normal pregnancy; it is more common after early pregnancy termination or spontaneous miscarriage [1]. Immediate consequences of RPOC include persistent vaginal bleeding, abdominal pain, pelvic infection, fever, and dilated cervix...
September 20, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28893657/the-effect-of-adjuvant-treatment-to-prevent-and-treat-intrauterine-adhesions-a-network-meta-analysis-of-randomized-controlled-trials
#13
REVIEW
Yu Yan, Dongmei Xu
Intrauterine adhesions (IUA) can lead to partial or complete closure of the uterine cavity, which may result in symptoms including abnormal menstruation, infertility, and pelvic pain. A network meta-analysis was performed to assess the effect of adjuvant therapy on the prevention and treatment of intrauterine adhesions. We searched electronic databases, including PubMed, EmBase, and the Cochrane Library, up to May 5, 2017 without language restrictions. The primary outcomes in the present analysis were the rate of IUAs for prevention and the rate of IUA recurrence for treatment...
September 8, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28883083/neupogen-and-mesenchymal-stem-cells-are-the-novel-therapeutic-agents-in-regeneration-of-induced-endometrial-fibrosis-in-experimental-rats
#14
Dina Sabry, Abeer Mostafa, Samar Marzouk, Walaa Ibrahim, Hanan H M Ali, Aymen Hassan, Ashraf Shamaa
Endometrial fibrosis is the presence of intrauterine adhesions (IUAs) after any uterine surgery or curettage and it results in infertility and recurrent pregnancy loss. We evaluated the role of human mesenchymal stem cells (hMSCs) as a therapeutic agent of endometrial fibrosis. We also compared the effect of MSCs with the effect of estrogen and neupogen either each alone or as a combined therapy with MSCs. This experimental study was performed on 84 albino rats which were divided into seven groups (n=12 rats/group) as follows, group1: normal control rats, group 2: induced fibrosis, group 3: induced fibrosis that received oral estrogen, group 4: induced fibrosis that received hMSCs, group 5: induced fibrosis that received hMSCs and estrogen, group 6: induced fibrosis that received neupogen, and group 7: induced fibrosis that received hMSCs and neupogen...
October 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28832907/complications-in-operative-hysteroscopy-is-prevention-possible
#15
Mee Kristine Aas-Eng, Anton Langebrekke, Gernot Hudelist
Operative hysteroscopy in a hospital setting has revolutionized surgical treatment of benign uterine disorders. It is minimally invasive, cost- and time-effective, and may spare patients major surgical interventions. Operative hysteroscopy in a day-case hospital setting is regarded as a safe and well-tolerated procedure with low complication rates. However, prevention of adverse events is crucial in daily practice to optimize patient care. Complications in operative hysteroscopy can be divided into early complications, including bleeding, uterine perforation, infection and fluid overload, or late complications and suboptimal outcomes, such as incomplete resection and intrauterine adhesions...
August 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28809108/dual-regulations-of-thermosensitive-heparin-poloxamer-hydrogel-using-%C3%AE%C2%B5-polylysine-bioadhesivity-and-controlled-kgf-release-for-enhancing-wound-healing-of-endometrial-injury
#16
He-Lin Xu, Jie Xu, Bi-Xin Shen, Si-Si Zhang, Bing-Hui Jin, Qun-Yan Zhu, De-Li ZhuGe, Xue-Qing Wu, Jian Xiao, Ying-Zheng Zhao
Hydrogel was not only used as an effective support matrix to prevent intrauterine adhesion after endometrial injury but also served as scaffold to sustain release of some therapeutics, especially growth factor. However, because of the rapid turnover of the endometrial mucus, the poor retention and bad absorption of therapeutic agents in damaged endometrial cavity were two important factors hindering their pharmacologic effect. Herein, a mucoadhesive hydrogel was described by using heparin-modified poloxamer (HP) as the matrix material and ε-polylysine (EPL) as functional excipient...
August 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28807808/safety-and-efficacy-of-amnion-graft-in-preventing-reformation-of-intrauterine-adhesions
#17
Xuebing Peng, TinChiu Li, Yuting Zhao, Yan Guo, Enlan Xia
STUDY OBJECTIVE: To determine the safety and efficacy of amnion grafts in preventing the recurrence of intrauterine adhesions after hysteroscopic adhesiolysis in women with severe intrauterine adhesions. DESIGN: A retrospective matched cohort study including 120 patients treated during 62 months (Canadian Task Force classification II-2). SETTING: A tertiary referral center. PATIENTS: A total of 120 patients who underwent intrauterine adhesiolysis for severe intrauterine adhesions: 40 patients in the treatment group and 80 patients in the control group matched for age and adhesion scores...
November 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28723687/small-intestine-submucosa-is-a-potential-material-for-intrauterine-adhesions-treatment-in-a-rat-model
#18
Desheng Kong, Lin Zhang, Xin Xu, Jingkun Zhang, Yanan Li, Xianghua Huang
OBJECTIVE: To study whether small intestine submucosa (SIS) could be a treatment option for preventing the formation of intrauterine adhesions (IUAs). METHODS: The IUAs model was established by mechanical curettage and infectious injury in a rat model. One uterine horn of the rat model was treated with the transplantation of SIS (SIS group) and the other one was left without any treatment (control group). The endometrium was evaluated with endometrial thickness, number of glands and fibrosis area...
July 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28603474/aagl-practice-report-practice-guidelines-on-intrauterine-adhesions-developed-in-collaboration-with-the-european-society-of-gynaecological-endoscopy-esge
#19
(no author information available yet)
No abstract text is available yet for this article.
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28602478/short-term-copper-intrauterine-device-placement-improves-the-implantation-and-pregnancy-rates-in-women-with-repeated-implantation-failure
#20
Xiaoyan Mao, Jie Zhang, Qiuju Chen, Yanping Kuang, Shaozhen Zhang
OBJECTIVE: To study if hysteroscopy and short-term copper intrauterine device placement (Cu-IUD) improves the pregnancy rates of women with repeated implantation failure (RIF) undergoing frozen-thawed embryo transfer (FET). DESIGN: Retrospective study. SETTING: Medical university hospital. PATIENT(S): Infertile women with at least two implantation failures with the use of at least one good-quality embryo. INTERVENTION(S): All patients received operative hysteroscopy in the follicular cycle, and if endometrial polyps, polypoid endometrium, or intrauterine adhesions were found they were removed...
July 2017: Fertility and Sterility
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