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intrauterine adhesions

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https://www.readbyqxmd.com/read/29896250/diagnostic-value-of-detection-of-serum-%C3%AE-hcg-and-ct-igg-combined-with-transvaginal-ultrasonography-in-early-tubal-pregnancy
#1
Hongyan Xin, Wenlian Liu, Ping Li
The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while 55 subjects of normal intrauterine pregnancy were enrolled as the intrauterine pregnancy group. Transvaginal ultrasonography and quantitative detection of serum β-HCG and CT-IgG were performed for all patients, and the clinical examination results were analyzed and compared...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29883518/the-immunoproteasome-inhibitor-onx-0914-regulates-inflammation-and-expression-of-contraction-associated-proteins-in-myometrium
#2
Stella Liong, Ratana Lim, Caitlyn Nguyen-Ngo, Gillian Barker, Helena C Parkington, Martha Lappas
There is currently no effective treatments to prevent spontaneous preterm labour. The precise upstream biochemical pathways that regulate the transition between uterine quiescence during pregnancy and contractility during labour remain unclear. It is well known however that intrauterine inflammation, including infection, is commonly associated with preterm labour. In this study, we identified the immunoproteasome subunit low-molecular-mass protein (LMP)7 mRNA expression to be significantly upregulated in labouring human myometrium...
June 8, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29858908/a-multidisciplinary-approach-to-pregnancy-loss-the-pregnancy-loss-prevention-center
#3
Bruce K Young
Pregnancy loss is probably the most common problem faced by women worldwide. There are differences in the rates of early and late pregnancy loss based on geography among the developing compared with the developed nations of the world. Most physicians worldwide have different criteria for treating pregnancy loss. Although pregnancy loss is not a disease, it might be best approached with a medical evaluation in order to define the cause and offer specific treatment. This report describes the results obtained by a multi-disciplinary pregnancy loss prevention center in the initial 104 patients...
June 2, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29747214/intestinal-perforation-due-to-deep-infiltrating-endometriosis-during-pregnancy-case-report
#4
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29732749/creation-of-a-rabbit-model-for-intrauterine-adhesions-using-electrothermal-injury
#5
Xin-Xin Xu, Lian-Bao Cao, Zhe Wang, Zhen Xu, Bing-Qian Zhang, She-Ling Wu, Sha-Sha Qi, Lei Yan, Zi-Jiang Chen
The pathogenesis and therapeutic treatment of intrauterine adhesions (IUAs) remain unsolved, highlighting the need for stable and effective experimental animal models. In this study, uterine electrocoagulation of twenty-one female New Zealand White rabbits was carried out to establish an IUA model. As rabbits have two completely separate uterine horns, each rabbit had its own internal control: one uterine horn was given an electrothermal injury (Group A, n=21), and the contralateral uterine horn received no treatment and served as the control (Group B, n=21)...
May 2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29678756/new-crosslinked-hyaluronan-gel-for-the-prevention-of-intrauterine-adhesions-after-dilation-and-curettage-in-patients-with-delayed-miscarriage-a-prospective-multicenter-randomized-controlled-trial
#6
Xueying Li, Ling Wu, Yanfei Zhou, Xing Fan, Jufang Huang, Juhua Wu, Renxiu Yu, Jianying Lou, Mengjie Yang, Zhihong Yao, Min Xue
STUDY OBJECTIVES: To evaluate the efficacy of a new crosslinked hyaluronan (NCH) gel in reducing the formation of intrauterine adhesions (IUAs) after dilation and curettage (D&C). DESIGN: Randomized controlled trial (Canadian Task Force classification I). SETTINGS: Six hospitals for maternal and child healthcare in China. PATIENTS: A total of 300 patients were randomized to undergo D&C for delayed miscarriage without previous history of D&C...
April 17, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29626375/the-link-between-intrauterine-adhesions-and-induced-termination-of-pregnancy-remains-a-challenge
#7
A B Hooker
No abstract text is available yet for this article.
April 6, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#8
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568895/abnormal-expression-of-fibrosis-markers-estrogen-receptor-%C3%AE-and-stromal-derived-factor%C3%A2-1-chemokine-c%C3%A2-x%C3%A2-c-motif-receptor%C3%A2-4-axis-in-intrauterine-adhesions
#9
Qin Zhou, Xixi Wu, Jianguo Hu, Rui Yuan
Intrauterine adhesions (IUAs) are mainly derived from fibrous tissue formation following endometrial damage. The aim of the present study was to assess whether fibrosis markers, estrogen receptor (ER)α and the stromal derived factor (SDF)‑1/C‑X‑C chemokine receptor type 4 (CXCR‑4) axis are abnormally expressed in IUA endometrium. A total of 76 human endometrial biopsy samples (normal, n=20; mild‑to‑moderate IUAs, n=40; and severe IUAs, n=16) were employed, and Sprague‑Dawley rat IUA models at different time points were constructed...
July 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29532588/intrauterine-adhesions-following-an-induced-termination-of-pregnancy-a-nationwide-cohort-study
#10
M Mentula, J Männistö, M Gissler, O Heikinheimo, M Niinimäki
OBJECTIVE: Intrauterine adhesions (IUAs) are a problematic complication after termination of pregnancy, but their incidence is unknown. Our objective was to assess the incidence of IUAs following induced termination of pregnancy and the risk factors for IUAs. DESIGN: Retrospective cohort study. SETTING: A nationwide registry study. SAMPLE: All women undergoing induced termination of pregnancy (n = 80 015) in Finland between 2000 and 2008...
March 13, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29514160/efficacy-and-safety-of-hyaluronic-acid-gel-for-the-prevention-of-intrauterine-adhesion-a-meta-analysis-of-randomized-clinical-trials
#11
Huafang Liu, Yanli Xu, Nuo Yi, Wei Yi
BACKGROUND: The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). METHODS: PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. RESULTS: Six RCTs with a total of 564 patients met the inclusion criteria. The meta-analysis showed that, compared to no other treatment method, hyaluronic acid gel significantly reduced the rate of any IUA (risk ratio [RR] 0...
2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29512784/transdermal-estrogen-gel-and-oral-aspirin-combination-therapy-improves-fertility-prognosis-via-the-promotion-of-endometrial-receptivity-in-moderate-to-severe-intrauterine-adhesion
#12
Yugang Chi, Ping He, Li Lei, Yi Lan, Jianguo Hu, Ying Meng, Lina Hu
Intrauterine adhesion (IUA) is one of the most common gynecological diseases in women of reproductive age. IUA, particularlyin moderate to severe forms, accounts for a large percentage of infertility cases. Clinically, the first‑line treatment strategy for IUA is transcervical resection of adhesion (TCRA), followed by adjuvant postoperative treatment. Estrogen is one of the classic chemotherapies used following TCRA and contributes to preventing re‑adhesion following surgery. However, estrogen has limited effects in promoting pregnancy, which is the ultimate goal for IUA management...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29504823/a-cohort-study-comparing-4-mg-and-10-mg-daily-doses-of-postoperative-oestradiol-therapy-to-prevent-adhesion-reformation-after-hysteroscopic-adhesiolysis
#13
Linlin Liu, Xiaowu Huang, Enlan Xia, Xiaoyu Zhang, Tin-Chiu Li, Yuhuan Liu
This is a retrospective cohort study conducted in a national training centre for hysteroscopy between January 2012 and December 2014 to compare the clinical outcome of two doses of oestradiol valerate (4 mg and 10 mg daily) in the prevention of recurrence of adhesions after hysteroscopic adhesiolysis. A total of 176 women who suffered from Asherman syndrome with moderate to severe intrauterine adhesions were included: 91 subjects received a 10 mg daily dose of oestradiol and 85 subjects received a 4 mg daily dose of oestradiol in the postoperative period...
March 5, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29483785/the-effect-of-endometrial-thickness-on-pregnancy-outcome-in-patients-with-asherman-s-syndrome-post-hysteroscopic-adhesiolysis
#14
Saeed Baradwan, Dina Shafi, Amira Baradwan, Muhammad Salman Bashir, Dania Al-Jaroudi
Background: Hysteroscopic adhesiolysis anatomically restores the uterine cavity in cases of Asherman's syndrome (AS); however, the extent of endometrial fibrosis could determine the pregnancy outcome. Objectives: To determine whether endometrial thickness could influence pregnancy outcome of hysteroscopic adhesiolysis in women with a history of AS. Subjects and methods: This was a retrospective cohort study that included 41 women who attended Women's Specialized Hospital, King Fahad Medical City from December 2008 to December 2015, presented with a history of infertility or recurrent pregnancy loss, and were diagnosed with intrauterine adhesions and treated by hysteroscopic adhesiolysis...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29480850/functional-analysis-of-cell-free-rna-using-mid-trimester-amniotic-fluid-supernatant-in-pregnancy-with-the-fetal-growth-restriction
#15
Hee Young Cho, Yeonkyung Cho, Yun-Jeong Shin, Jieun Park, Sunghan Shim, Yongwook Jung, Sungshin Shim, Donghyun Cha
The prediction and monitoring of fetal growth restriction (FGR) fetuses has become with the use of ultrasound. However, these tools lack the fundamental evidence for the growth of fetus with FGR excluding pathogenic factors.Amniotic fluid samples were obtained from pregnant women for fetal karyotyping and genetic diagnosis at 16 to 19 weeks of gestation. For this study, 15 FGR and 9 control samples were selected, and cell-free fetal RNA was isolated from each supernatant of the amniotic fluid for microarray analysis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29456102/the-prognostic-capacity-of-transvaginal-hydrolaparoscopy-to-predict-non-ivf-conception
#16
Mianne van Kessel, Rachel Tros, Jur Oosterhuis, Walter H Kuchenbecker, Elly M Vernooij, Marlies Y Bongers, Ben Willem J Mol, Carolien A Koks
Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan-Meier analysis and fecundity rate ratios (FRR) were established...
May 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29454580/are-synechiae-a-complication-of-laparotomic-myomectomy
#17
Perrine Capmas, Anne-Gaelle Pourcelot, Hervé Fernandez
Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study took place in a teaching hospital from May 2009 to June 2014. It included all women aged 18-45 years who had laparotomic myomectomies (without diagnostic hysteroscopy at the time of surgery) for myomas and a postoperative diagnostic office hysteroscopy 6-8 weeks later...
April 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29393381/feasibility-analysis-of-treating-severe-intrauterine-adhesions-by-transplanting-menstrual-blood-derived-stem-cells
#18
Sheng-Xia Zheng, Jian Wang, Xue-Li Wang, Asim Ali, Li-Min Wu, Yu-Sheng Liu
Intrauterine adhesions (IUA) are associated with the loss of stem cells in the endometrium. Menstrual blood‑derived stem cells (MenSCs) can be isolated from the menstrual blood and differentiated into endometrial cells. To check the transplantation feasibility of MenSCs for the treatment of severe IUA, MenSCs were isolated from menstrual blood, cultured in Dulbecco's modified Eagle's medium (DMEM), identified by immunocytochemistry and flow cytometry, differentiated into endometrial cells in vitro, and finally transplanted into the axillary subcutaneous tissue of non‑obese diabetic/severe combined immunodeficiency (NOD‑SCID) mice to create endometrial tissue...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29386988/clinical-characteristic-and-intraoperative-findings-of-uterine-perforation-patients-in-using-of-intrauterine-devices-iuds
#19
Xin Sun, Min Xue, Xinliang Deng, Yun Lin, Ying Tan, Xueli Wei
Background: Intrauterine devices (IUDs) are the most popular form of contraception used worldwide; however, IUD is not risk-free. IUD migrations, especially uterine perforations, were frequently occurred in patients. The aim of this study was to investigate the clinical characteristics and intraoperative findings in patients with migrated IUDs. Results: 29 cases of uterine perforation associated with migrated IUDs and 69 control patients were followed between January 2008 to March 2015...
2018: Gynecological Surgery
https://www.readbyqxmd.com/read/29338827/risk-factors-of-intrauterine-adhesion-after-hysteroscopic-resection-of-endometrial-polyps
#20
Li Su, Lan You, Hong Ping Huang
Objective To analyze the risk factors of intrauterine adhesion (IUA) after hysteroscopic resection of endometrial polyps. Methods Totally 359 patients undergoing hysteroscopic resection of endometrial polyps from January 2013 to December 2016 were enrolled in this study. The clinical data of IUA group and non-IUA group were compared. Univariate analysis was performed to identify the risk factors of IUA,and multivariate Logistic regression analysis was further performed to get the independent risk factors. Results Of these 359 patients,IUA occured after operation in 56 patients (15...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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