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intrauterine adhesions

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https://www.readbyqxmd.com/read/28434729/effects-of-intrauterine-infusion-of-escherichia-coli-lipopolysaccharide-on-uterine-mrna-gene-expression-and-peripheral-polymorphonuclear-leukocytes-in-jersey-cows-diagnosed-with-purulent-vaginal-discharge
#1
João G N Moraes, Luís G D Mendonça, Paula R B Silva, Alexandre A Scanavez, Klibs N Galvão, Michael A Ballou, Milli Worku, Ricardo C Chebel
The objectives of the current experiment were to investigate the effects of intrauterine treatment of cows with purulent vaginal discharge (PVD) using lipopolysaccharide (LPS) from Escherichia coli on uterine mRNA expression of genes related to inflammatory responses, peripheral polymorphonuclear leukocyte (PMN) function, hematological parameters, and blood concentrations of cortisol, haptoglobin, and progesterone (P4). Jersey cows (n = 3,084) were examined for PVD at 35 ± 6 d postpartum using the Metricheck device (Simcro, Hamilton, New Zealand)...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28421909/management-of-intra-abdominally-translocated-contraceptive-devices-is-surgery-the-only-way-to-treat-this-problem
#2
Mustafa Gazi Uçar, Fatih Şanlıkan, Tolgay Tuyan Ilhan, Ahmet Göçmen, Çetin Çelik
This study was a multi-centre retrospective review of patients with uterine perforation caused by intrauterine contraceptive devices (IUDs). A total of 15 patients were registered, in a seven year period. Among them, five were asymptomatic and the rest were symptomatic. Asymptomatic patients were managed conservatively, except in one case in which the patient requested surgery because she also wanted a tubal ligation. Symptomatic patients all underwent surgery. All the surgeries were elective and all the surgical procedures were initiated laparoscopically...
May 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28412850/assessment-of-hysteroscopic-role-in-management-of-women-with-recurrent-pregnancy-loss
#3
M Elsokkary, M Elshourbagy, K Labib, M Ali
OBJECTIVES: To assess the hysteroscopic value in the management of intrauterine lesion in women with recurrent pregnancy loss. METHODS: This study done in Ain Shams Maternity Hospital after the approval of the research Ethics Committee, during the period between August 2014 to December 2015 where 200 non-pregnant women with a history of three or more consecutive unexplained first and second trimester miscarriages before 20 weeks were recruited from recurrent miscarriage clinic...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28390688/prevalence-of-intrauterine-adhesions-after-the-application-of-hyaluronic-acid-gel-after-dilatation-and-curettage-in-women-with-at-least-one-previous-curettage-short-term-outcomes-of-a-multicenter-prospective-randomized-controlled-trial
#4
Angelo B Hooker, Robert de Leeuw, Peter M van de Ven, Erica A Bakkum, Andreas L Thurkow, Niels E A Vogel, Huib A A M van Vliet, Marlies Y Bongers, Mark H Emanuel, Annelies E M Verdonkschot, Hans A M Brölmann, Judith A F Huirne
OBJECTIVE: To examine whether intrauterine application of auto-crosslinked hyaluronic acid (ACP) gel, after dilatation and curettage (D&C), reduces the incidence of intrauterine adhesions (IUAs). DESIGN: Multicenter; women and assessors blinded prospective randomized trial. SETTING: University and university-affiliated teaching hospitals. PATIENT(S): A total of 152 women with a miscarriage of <14 weeks with at least one previous D&C for miscarriage or termination of pregnancy...
April 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28345485/the-effect-of-tamoxifen-on-thin-endometrium-in-patients-undergoing-frozen-thawed-embryo-transfer
#5
Hanni Ke, Jingjing Jiang, Mingdi Xia, Rong Tang, Yingying Qin, Zi-Jiang Chen
Tamoxifen has played a vital role in endocrine therapy for the treatment of estrogen receptor-positive breast cancer. We examined the effect of tamoxifen in patients with a thin endometrium in frozen-thawed embryo transfer (FET) cycles and compared the improvement in endometrial thickness (EMT) and pregnancy outcomes stratified by different etiologies of thin endometrium. A total of 226 women were recruited for a new tamoxifen protocol; all had an EMT of less than 7.5 mm in previous cycles, including natural cycle (NC), hormone replacement treatment (HRT), and ovulation induction (OI) cycles...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28285950/human-amniotic-mesenchymal-stromal-cell-transplantation-improves-endometrial-regeneration-in-rodent-models-of-intrauterine-adhesions
#6
Lu Gan, Hua Duan, Qian Xu, Yi-Qun Tang, Jin-Jiao Li, Fu-Qing Sun, Sha Wang
BACKGROUND AIMS: Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a valuable resource for transplantation therapy, could improve endometrial regeneration in rodent IUA models. METHODS: Forty female Sprague-Dawley rats were randomly assigned to five groups: normal, sham-operated, mechanical injury, hAMSC transplantation, and negative control group...
May 2017: Cytotherapy
https://www.readbyqxmd.com/read/28253866/expression-of-sox2-nanog-and-oct4-in-a-mouse-model-of-lipopolysaccharide-induced-acute-uterine-injury-and-intrauterine-adhesions
#7
Li Xiao, Yong Song, Wei Huang, Shiyuan Yang, Jing Fu, Xue Feng, Min Zhou
BACKGROUND: Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot, in that human endometrial stem cells have been isolated from the endometrium. Three transcription factors that play key roles in maintaining pluripotency and self-renewal in stem cells are sex-determining region Y-box2 (SOX2), Nanog homebox (NANOG), and octamer-binding protein (OCT4), which may be responsible for the damage or repair process of uterine endometrium...
March 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28251159/effects-of-aspirin-and-intrauterine-balloon-on-endometrial-repair-and-reproductive-prognosis-in-patients-with-severe-intrauterine-adhesion-a-prospective-cohort-study
#8
Yuqing Chen, Lixiang Liu, Yuanna Luo, Minghui Chen, Yang Huan, Ruili Fang
This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28170094/efficacy-of-freeze-dried-amnion-graft-following-hysteroscopic-adhesiolysis-of-severe-intrauterine-adhesions
#9
Lu Gan, Hua Duan, Fu-Qing Sun, Qian Xu, Yi-Qun Tang, Sha Wang
OBJECTIVE: To evaluate the efficacy of freeze-dried amnion graft for prevention of intrauterine adhesion (IUA) reformation after hysteroscopic adhesiolysis. METHODS: A prospective randomized controlled trial was conducted among 88 women with severe IUAs who underwent hysteroscopic adhesiolysis at Beijing Obstetrics and Gynecology Hospital between July 15, 2015, and July 1, 2016. All participants had a balloon inserted into the uterine cavity for 1 week. Sterilized freeze-dried amnion graft covered the balloon portion of the Foley catheter among patients allocated to the amnion group (n=44), whereas patients in the control group (n=44) did not receive the graft...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28153659/enoxaparin-for-the-prevention-of-preeclampsia-and%C3%A2-intrauterine-growth-restriction-in-women-with%C3%A2-a%C3%A2-history-%C3%A2-a%C3%A2-randomized-trial
#10
Katie M Groom, Lesley M McCowan, Laura K Mackay, Arier C Lee, Joanne M Said, Stefan C Kane, Susan P Walker, Thijs E van Mens, Natalie J Hannan, Stephen Tong, Larry W Chamley, Peter R Stone, Claire McLintock
BACKGROUND: Preeclampsia and small-for-gestational-age pregnancy are major causes of maternal and perinatal morbidity and mortality. Women with a previous pregnancy affected by these conditions are at an increased risk of recurrence in a future pregnancy. Past trials evaluating the effect of low-molecular-weight heparin for the prevention of recurrence of preeclampsia and small-for-gestational-age pregnancy have shown conflicting results with high levels of heterogeneity displayed when trials were compared...
March 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28148903/elevated-nf-%C3%AE%C2%BAb-signaling-in-asherman-syndrome-patients-and-animal-models
#11
Xiangzhen Wang, Nana Ma, Qiannan Sun, Chenlingzi Huang, Yanmei Liu, Xin Luo
Asherman syndrome (intrauterine adhesion) is often associated with menstrual abnormalities, infertility and recurrent miscarriage in female. Currently the molecular mechanism regulating the pathogenesis of Asherman syndrome is not known. Here we revealed that the inflammatory factor NF-κB expression is significantly elevated in the endometrial samples of Asherman syndrome patients. To further study the molecular mechanisms, we established an Asherman syndrome rat model and confirmed the important role of NF-κB in the pathogenesis of Asherman syndrome...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28034657/failure-of-physiologic-transformation-of-spiral-arteries-endothelial-and-trophoblast-cell-activation-and-acute-atherosis-in-the-basal-plate-of-the%C3%A2-placenta
#12
Carlos A Labarrere, Hector L DiCarlo, Elaine Bammerlin, James W Hardin, Yeon M Kim, Piya Chaemsaithong, David M Haas, Ghassan S Kassab, Roberto Romero
BACKGROUND: Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. There are striking parallels between preeclampsia and atherosclerotic disease, and between lesions of atherosis and atherosclerosis. Endothelial activation, identified by intercellular adhesion molecule-1 expression, is present in atherosclerotic-like lesions of heart transplantation, and is considered a manifestation of rejection...
December 27, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#13
Che-Ying Kuo, Hannah Baker, Melissa H Fries, James J Yoo, Peter C W Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations, and hysterectomy. These strategies can be classified into two broad categories as follows: (i) Transplantation of fresh or cryopreserved organs into the host and (ii) tissue engineering approaches that utilize a combination of cells, growth factors, and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
February 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27998009/endometriosis-associated-infertility-aspects-of-pathophysiological-mechanisms-and-treatment-options
#14
REVIEW
Tom Tanbo, Peter Fedorcsak
Endometriosis is a common condition in women of reproductive age. In addition to pain, endometriosis may also reduce fertility. The causes of infertility in women with endometriosis may range from anatomical distortions due to adhesions and fibrosis to endocrine abnormalities and immunological disturbances. In some cases, the various pathophysiological disturbances seem to interact through mechanisms so far not fully understood. Whether surgery should be offered as a treatment option in endometriosis-associated infertility has become controversial, partly due to its modest or undocumented effect...
December 20, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27979666/cesarean-scar-pregnancy-comparing-the-efficacy-and-tolerability-of-treatment-with-high-intensity-focused-ultrasound-and-uterine-artery-embolization
#15
Juhua Xiao, Zhen Shi, Jinshui Zhou, Jun Ye, Jianfang Zhu, Xin Zhou, Fang Wang, Shouhua Zhang
The aim of this study was to investigate the clinical efficacy of high-intensity focused ultrasound (HIFU) for the treatment of a cesarean scar pregnancy compared with uterine artery embolization (UAE) and intra-arterial methotrexate infusion combined with uterine curettage. In this retrospective cohort study, 31 patients were treated with HIFU (HIFU group), and 45 patients were treated with UAE (UAE group). We compared the treatment and recovery of the patients, including follow-up. After UAE treatment, serum levels of the β subunit of human chorionic gonadotropin declined significantly on the first day, and the residual lesions disappeared in 3-17 wk...
December 12, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27856386/reproductive-outcome-in-patients-with-intrauterine-adhesions-following-hysteroscopic-adhesiolysis-experience-from-the-largest-women-s-hospital-in-china
#16
Limei Chen, Hongwei Zhang, Qing Wang, Feng Xie, Shujun Gao, Yu Song, Jing Dong, Hua Feng, Kangyun Xie, Long Sui
STUDY OBJECTIVE: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs) DESIGN: Retrospective , cross-sectional study (Canadian Task Force classification II-2). SETTING: University tertiary referral center PATIENTS: Three hundred and fifty seven patients with mild, moderate, and severe IUAs underwent hysteroscopic adhesiolysis between January 2012 and December 2015 INTERVENTIONS: Hysteroscopic adhesiolysis in the outpatient analgesic setting for infertility and IUAs...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27823367/complications-associated-with-intrauterine-glass-marbles-in-five-mares
#17
Mariana Diel de Amorim, Tracey Chenier, Dawne Nairn, Jodyne Green, Stephen Manning, Claire Card
CASE DESCRIPTION 5 mares were evaluated because of reproductive complications following long-term (> 1 year) use of intrauterine glass marbles for estrus suppression. CLINICAL FINDINGS 3 mares had 1 intrauterine glass marble, and 2 mares had 2 intrauterine glass marbles. On examination, 2 mares had signs of chronic endometritis, and 3 had signs of pyometra. Marbles or glass shards adhered to the endometrium were identified by means of hysteroscopy in 3 of 5 mares. Five of 7 marbles had surface imperfections or were broken...
November 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27806819/secondary-infertility-due-to-retained-fetal-bones-diagnosed-via-saline-sonography
#18
Rubina Izhar, Samia Husain, Suhaima Tahir, Sonia Husain
Prolonged intrauterine retention of any fetal bones can lead to secondary infertility. The exact incidence remains unclear. This case report describes a 36-year woman with secondary infertility of eight years. Workup revealed echogenic foci partially embedded in endometrium on saline sonography. After ultrasound guided dilation and curettage, fetal bones were retrieved. Unexplained infertility can often be explained if before applying this label, uterine factor is also taken into account. When common causes like tubal blockage, male factor, and ovulatory dysfunction have been excluded, infrequent causes like polyps, adhesions, and in rare instances foreign bodies also should be looked for...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27792415/ultrasound-guided-transcervical-radiofrequency-ablation-for-symptomatic-uterine-adenomyosis
#19
Ning Hai, Qingxiang Hou, Xiaoping Ding, Xiangping Dong, Meijuan Jin
OBJECTIVE: To retrospectively evaluate the midterm outcomes of transvaginal ultrasound-guided radiofrequency ablation (RFA) for the treatment of symptomatic uterine adenomyosis. METHODS: 87 patients with symptomatic uterine adenomyosis, who met the inclusion criteria, were enrolled in our study from January 2013 to October 2015. All of the patients underwent transvaginal ultrasound-guided RFA and were followed up for 12 months. Assessment end points included uterus volume reduction rate, lesion regression rate, dysmenorrhoeal score, symptom severity score (SSS) and adverse events...
January 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27773811/prevalence-and-impact-of-chronic-endometritis-in-patients-with-intrauterine-adhesions-a-prospective-cohort-study
#20
Yuqing Chen, Lixiang Liu, Yuanna Luo, Minghui Chen, Yang Huan, Ruili Fang
STUDY OBJECTIVE: To evaluate the prevalence and impact of chronic endometritis (CE) in patients with intrauterine adhesions (IUAs). DESIGN: Prospective cohort study (Canadian Task Force classification II-2). SETTING: University-affiliated hospital. PATIENTS: Eighty-two women with moderate to severe IUAs. INTERVENTIONS: Transcervical resection of adhesions (TCRA) and endometrial biopsy were performed in all patients...
January 1, 2017: Journal of Minimally Invasive Gynecology
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