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intrauterine adhesions

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https://www.readbyqxmd.com/read/29626375/the-link-between-intrauterine-adhesions-and-induced-abortion-remains-a-challenge
#1
Angelo B Hooker
Termination of pregnancy (TOP) or induced abortion is one of the most performed interventions on women of reproductive age; it is estimated that 30-50% of women will undergo at least one TOP during their lifetime (Templeton et al. N Engl J Med 2011;365:2198-204). Intrauterine adhesion (IUA) are thought to develop following destruction of the basal layer of the endometrium; in the healing process opposing walls of the uterus adhere together (Schenker. Eur J Obstet Gynecol Reprod Biol 1996:65;109-113). There is a link between induced abortion and IUA, but data concerning the incidence of IUA are conflicting...
April 6, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#2
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568895/abnormal-expression-of-fibrosis-markers-estrogen-receptor-%C3%AE-and-stromal-derived-factor%C3%A2-1-chemokine-c%C3%A2-x%C3%A2-c-motif-receptor%C3%A2-4-axis-in-intrauterine-adhesions
#3
Qin Zhou, Xixi Wu, Jianguo Hu, Rui Yuan
Intrauterine adhesions (IUAs) are mainly derived from fibrous tissue formation following endometrial damage. The aim of the present study was to assess whether fibrosis markers, estrogen receptor (ER)α and the stromal derived factor (SDF)‑1/C‑X‑C chemokine receptor type 4 (CXCR‑4) axis are abnormally expressed in IUA endometrium. A total of 76 human endometrial biopsy samples (normal, n=20; mild‑to‑moderate IUAs, n=40; and severe IUAs, n=16) were employed, and Sprague‑Dawley rat IUA models at different time points were constructed...
March 22, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29532588/intrauterine-adhesions-following-an-induced-abortion-a-nationwide-cohort-study
#4
M Mentula, J Männistö, M Gissler, O Heikinheimo, M Niinimäki
OBJECTIVE: Intrauterine adhesions (IUA) are a problematic complication after abortion, but their incidence is unknown. Our objective was to assess the incidence of IUA following induced abortion and the risk factors for IUA. DESIGN: Retrospective cohort study. SETTING: A nationwide registry study. SAMPLE: All women undergoing induced abortion (n = 80 015) in Finland between 2000 and 2008. METHODS: The data were retrieved from the Finnish Abortion Registry and the Hospital Discharge Registry...
March 13, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29514160/efficacy-and-safety-of-hyaluronic-acid-gel-for-the-prevention-of-intrauterine-adhesion-a-meta-analysis-of-randomized-clinical-trials
#5
Huafang Liu, Yanli Xu, Nuo Yi, Wei Yi
BACKGROUND: The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). METHODS: PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. RESULTS: Six RCTs with a total of 564 patients met the inclusion criteria. The meta-analysis showed that, compared to no other treatment method, hyaluronic acid gel significantly reduced the rate of any IUA (risk ratio [RR] 0...
March 7, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29512784/transdermal-estrogen-gel-and-oral-aspirin-combination-therapy-improves-fertility-prognosis-via-the-promotion-of-endometrial-receptivity-in-moderate-to-severe-intrauterine-adhesion
#6
Yugang Chi, Ping He, Li Lei, Yi Lan, Jianguo Hu, Ying Meng, Lina Hu
Intrauterine adhesion (IUA) is one of the most common gynecological diseases in women of reproductive age. IUA, particularlyin moderate to severe forms, accounts for a large percentage of infertility cases. Clinically, the first‑line treatment strategy for IUA is transcervical resection of adhesion (TCRA), followed by adjuvant postoperative treatment. Estrogen is one of the classic chemotherapies used following TCRA and contributes to preventing re‑adhesion following surgery. However, estrogen has limited effects in promoting pregnancy, which is the ultimate goal for IUA management...
March 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29504823/a-cohort-study-comparing-4-mg-and-10-mg-daily-doses-of-postoperative-oestradiol-therapy-to-prevent-adhesion-reformation-after-hysteroscopic-adhesiolysis
#7
Linlin Liu, Xiaowu Huang, Enlan Xia, Xiaoyu Zhang, Tin-Chiu Li, Yuhuan Liu
This is a retrospective cohort study conducted in a national training centre for hysteroscopy between January 2012 and December 2014 to compare the clinical outcome of two doses of oestradiol valerate (4 mg and 10 mg daily) in the prevention of recurrence of adhesions after hysteroscopic adhesiolysis. A total of 176 women who suffered from Asherman syndrome with moderate to severe intrauterine adhesions were included: 91 subjects received a 10 mg daily dose of oestradiol and 85 subjects received a 4 mg daily dose of oestradiol in the postoperative period...
March 5, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29483785/the-effect-of-endometrial-thickness-on-pregnancy-outcome-in-patients-with-asherman-s-syndrome-post-hysteroscopic-adhesiolysis
#8
Saeed Baradwan, Dina Shafi, Amira Baradwan, Muhammad Salman Bashir, Dania Al-Jaroudi
Background: Hysteroscopic adhesiolysis anatomically restores the uterine cavity in cases of Asherman's syndrome (AS); however, the extent of endometrial fibrosis could determine the pregnancy outcome. Objectives: To determine whether endometrial thickness could influence pregnancy outcome of hysteroscopic adhesiolysis in women with a history of AS. Subjects and methods: This was a retrospective cohort study that included 41 women who attended Women's Specialized Hospital, King Fahad Medical City from December 2008 to December 2015, presented with a history of infertility or recurrent pregnancy loss, and were diagnosed with intrauterine adhesions and treated by hysteroscopic adhesiolysis...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29480850/functional-analysis-of-cell-free-rna-using-mid-trimester-amniotic-fluid-supernatant-in-pregnancy-with-the-fetal-growth-restriction
#9
Hee Young Cho, Yeonkyung Cho, Yun-Jeong Shin, Jieun Park, Sunghan Shim, Yongwook Jung, Sungshin Shim, Donghyun Cha
The prediction and monitoring of fetal growth restriction (FGR) fetuses has become with the use of ultrasound. However, these tools lack the fundamental evidence for the growth of fetus with FGR excluding pathogenic factors.Amniotic fluid samples were obtained from pregnant women for fetal karyotyping and genetic diagnosis at 16 to 19 weeks of gestation. For this study, 15 FGR and 9 control samples were selected, and cell-free fetal RNA was isolated from each supernatant of the amniotic fluid for microarray analysis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29456102/the-prognostic-capacity-of-transvaginal-hydrolaparoscopy-to-predict-non-ivf-conception
#10
Mianne van Kessel, Rachel Tros, Jur Oosterhuis, Walter H Kuchenbecker, Elly M Vernooij, Marlies Y Bongers, Ben Willem J Mol, Carolien A Koks
Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan-Meier analysis and fecundity rate ratios (FRR) were established...
February 5, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29454580/are-synechiae-a-complication-of-laparotomic-myomectomy
#11
Perrine Capmas, Anne-Gaelle Pourcelot, Hervé Fernandez
Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study took place in a teaching hospital from May 2009 to June 2014. It included all women aged 18-45 years who had laparotomic myomectomies (without diagnostic hysteroscopy at the time of surgery) for myomas and a postoperative diagnostic office hysteroscopy 6-8 weeks later...
February 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29393381/feasibility-analysis-of-treating-severe-intrauterine-adhesions-by-transplanting-menstrual-blood-derived-stem-cells
#12
Sheng-Xia Zheng, Jian Wang, Xue-Li Wang, Asim Ali, Li-Min Wu, Yu-Sheng Liu
Intrauterine adhesions (IUA) are associated with the loss of stem cells in the endometrium. Menstrual blood‑derived stem cells (MenSCs) can be isolated from the menstrual blood and differentiated into endometrial cells. To check the transplantation feasibility of MenSCs for the treatment of severe IUA, MenSCs were isolated from menstrual blood, cultured in Dulbecco's modified Eagle's medium (DMEM), identified by immunocytochemistry and flow cytometry, differentiated into endometrial cells in vitro, and finally transplanted into the axillary subcutaneous tissue of non‑obese diabetic/severe combined immunodeficiency (NOD‑SCID) mice to create endometrial tissue...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29386988/clinical-characteristic-and-intraoperative-findings-of-uterine-perforation-patients-in-using-of-intrauterine-devices-iuds
#13
Xin Sun, Min Xue, Xinliang Deng, Yun Lin, Ying Tan, Xueli Wei
Background: Intrauterine devices (IUDs) are the most popular form of contraception used worldwide; however, IUD is not risk-free. IUD migrations, especially uterine perforations, were frequently occurred in patients. The aim of this study was to investigate the clinical characteristics and intraoperative findings in patients with migrated IUDs. Results: 29 cases of uterine perforation associated with migrated IUDs and 69 control patients were followed between January 2008 to March 2015...
2018: Gynecological Surgery
https://www.readbyqxmd.com/read/29338827/risk-factors-of-intrauterine-adhesion-after-hysteroscopic-resection-of-endometrial-polyps
#14
Li Su, Lan You, Hong Ping Huang
Objective To analyze the risk factors of intrauterine adhesion (IUA) after hysteroscopic resection of endometrial polyps. Methods Totally 359 patients undergoing hysteroscopic resection of endometrial polyps from January 2013 to December 2016 were enrolled in this study. The clinical data of IUA group and non-IUA group were compared. Univariate analysis was performed to identify the risk factors of IUA,and multivariate Logistic regression analysis was further performed to get the independent risk factors. Results Of these 359 patients,IUA occured after operation in 56 patients (15...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29329377/endometrial-stem-cell-derived-g-csf-attenuates-endometrial-fibrosis-via-sonic-hedgehog-transcriptional-activator-gli2
#15
Xiaona Lin, Yanling Zhang, Yibin Pan, Shilin He, Yongdong Dai, Bingqing Zhu, Cheng Wei, Liaobing Xin, Wenzhi Xu, Chunsheng Xiang, Songying Zhang
Intrauterine adhesion (IUA) is characterized by endometrial fibrosis, which ultimately leads to menstrual abnormalities, infertility and recurrent miscarriages. The Shh/Gli2 pathway plays a critical role in tissue fibrogenesis and regeneration; Gli2 activation induces profibrogenic effects in various tissues, such as the liver and kidney. However, the role of Gli2 in endometrial fibrosis remains unknown. The purpose of this study was to test the hypothesis that activated Gli2 promotes endometrial fibrosis. Endometrial samples from moderate and severe IUA patients exhibited significantly enhanced expression of Gli2 compared with normal endometrial samples and mild IUA samples...
January 10, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29316041/bilateral-tubo-ovarian-abscesses-presenting-with-huge-pelvic-mass-after-repeated-intrauterine-inseminations-in-a-woman-with-severe-endometriosis
#16
Patsama Vichinsartvichai
A 32-year-old woman consulted for an evaluation of pelvic pain following intrauterine insemination (IUI). Vaginal and abdominal sonography, septic workup were performed and laparoscopic surgery was scheduled after failure to respond to a course of antibiotics. During laparoscopic surgery, bilateral tubo-ovarian abscesses arising on the endometriotic cysts of both ovaries were identified with a vast amount of brownish peritoneal fluid under the adhesion of the greater omentum. Bilateral ovarian cystectomy, right salpingectomy and lysis adhesion were performed...
April 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29287116/lung-microrna-deregulation-associated-with-impaired-alveolarization-in-rats-after-intrauterine-growth-restriction
#17
Pauline Dravet-Gounot, Cécile Morin, Sébastien Jacques, Florent Dumont, Fabiola Ely-Marius, Daniel Vaiman, Pierre-Henri Jarreau, Céline Méhats, Elodie Zana-Taïeb
Intrauterine growth restriction (IUGR) was recently described as an independent risk factor of bronchopulmonary dysplasia, the main respiratory sequelae of preterm birth. We previously showed impaired alveolarization in rat pups born with IUGR induced by a low-protein diet (LPD) during gestation. We conducted a genome-wide analysis of gene expression and found the involvement of several pathways such as cell adhesion. Here, we describe our unbiased microRNA (miRNA) profiling by microarray assay and validation by qPCR at postnatal days 10 and 21 (P10 and P21) in lungs of rat pups with LPD-induced lung-alveolarization disorder after IUGR...
2017: PloS One
https://www.readbyqxmd.com/read/29203342/effect-of-early-second-look-hysteroscopy-on-reproductive-outcomes-after-hysteroscopic-adhesiolysis-in-patients-with-intrauterine-adhesion-a-retrospective-study-in-china
#18
Wenzhi Xu, Yuxue Zhang, Yang Yang, Songying Zhang, Xiaona Lin
OBJECTIVE: The aim of this study was to assess the effect of early second-look hysteroscopy after hysteroscopic adhesiolysis for intrauterine adhesions (IUAs) on the pregnancy rate (PR) and live birth rate (LBR). STUDY DESIGN: It is a retrospective, observational study of 151 women were referred to our institution from January 2010 to January 2016. Operative hysteroscopy for treatment of IUAs and office hysteroscopic follow-up to assess IUAs. We investigated demographic characteristics, menstrual pattern, previous intrauterine surgery, reproductive history, ovarian preservation assessment, tubal patency examination, husband's semen test, obstetric parameters, and surgical variables to evaluate the effect of early second-look hysteroscopy after hysteroscopic adhesiolysis on the PR and LBR...
February 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29196267/intrauterine-exosomes-are-required-for-bovine-conceptus-implantation
#19
Kazuya Kusama, Keigo Nakamura, Rulan Bai, Kentaro Nagaoka, Toshihiro Sakurai, Kazuhiko Imakawa
Exosomes, extracellular vesicles, are present in uterine flushing fluids (UFs), which are involved in conceptus-endometrial interactions during peri-implantation periods. Despite several studies on intrauterine exosomes conducted, the roles conceptus and endometrial exosomes play during peri-implantation periods have not been well characterized. To investigate the effect of bovine intrauterine exosomes on conceptus implantation, exosomes isolated from bovine UFs during peri-implantation periods were subjected to global protein analysis...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29178172/anti-adhesion-therapy-following-operative-hysteroscopy-for-treatment-of-female-subfertility
#20
REVIEW
Jan Bosteels, Steven Weyers, Thomas M D'Hooghe, Helen Torrance, Frank J Broekmans, Su Jen Chua, Ben Willem J Mol
BACKGROUND: Observational evidence suggests a potential benefit with several anti-adhesion therapies in women undergoing operative hysteroscopy (e.g. insertion of an intrauterine device or balloon, hormonal treatment, barrier gels or human amniotic membrane grafting) for decreasing intrauterine adhesions (IUAs). OBJECTIVES: To assess the effectiveness of anti-adhesion therapies versus placebo, no treatment or any other anti-adhesion therapy, following operative hysteroscopy for treatment of female subfertility...
November 27, 2017: Cochrane Database of Systematic Reviews
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