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microneedle hpv

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https://www.readbyqxmd.com/read/25785935/vaccination-with-human-papillomavirus-pseudovirus-encapsidated-plasmids-targeted-to-skin-using-microneedles
#1
Rhonda C Kines, Vladimir Zarnitsyn, Teresa R Johnson, Yuk-Ying S Pang, Kizzmekia S Corbett, John D Nicewonger, Anu Gangopadhyay, Man Chen, Jie Liu, Mark R Prausnitz, John T Schiller, Barney S Graham
Human papilloma virus-like particles (HPV VLP) serve as the basis of the current licensed vaccines for HPV. We have previously shown that encapsidation of DNA expressing the model antigen M/M2 from respiratory syncytial virus (RSV) in HPV pseudovirions (PsV) is immunogenic when delivered intravaginally. Because the HPV capsids confer tropism for basal epithelium, they represent attractive carriers for vaccination targeted to the skin using microneedles. In this study we asked: 1) whether HPV16 VLP administered by microneedles could induce protective immune responses to HPV16 and 2) whether HPV16 PsV-encapsidated plasmids delivered by microneedles could elicit immune responses to both HPV and the antigen delivered by the transgene...
2015: PloS One
https://www.readbyqxmd.com/read/19175177/-the-effect-of-hpv16e7-dna-vaccine-transdermal-delivery-with-microneedle-array
#2
Hui Gao, Jin-Chun Pan, Bing Chen, Zheng-Feng Xue, Hou-Da Li
OBJECTIVE: To study the effects of DNA vaccine transdermal delivery with microneedle array. METHODS: The pcDNA3.1-HPV16E7 recombinant vector acting as gene vaccine was established. The infiltration quantity of pcDNA3.1-HPV16E7 getting across the microchannels generated by microneedle arrays in vitro was observed. 30 BALB/c mice were divided into 3 groups (experimental group, in vain plasmid group, negative control). Each group had 10 mice. Then immunized BALB/c mice with a dose of 200 microg with microneedle array every two weeks...
September 2008: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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