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microneedle hpv

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https://www.readbyqxmd.com/read/29687566/intralesional-bleomycin-injection-vs-microneedling-assisted-topical-bleomycin-spraying-in-treatment-of-plantar-warts
#1
Mohamed R Al-Naggar, Ahmad S Al-Adl, Ali R Rabie, Mahmoud R Abdelkhalk, Mohamed L Elsaie
BACKGROUND: Warts, or verrucae, are benign epithelial profilerations of skin and mucosa caused by infection with HPV and poses a challenge to treat. OBJECTIVE: To compare between single and microneedling-assisted multipuncture techniques of intralesional application in treatment of plantar warts. METHODS: The study included 60 Patients who were divided into two groups (A&B). Each group consisted of (30) patients. Group (A) subjects received intralesional bleomycin with a single injection using syringe needle...
April 23, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29174441/hollow-microneedle-mediated-micro-injections-of-a-liposomal-hpv-e7-43-63-synthetic-long-peptide-vaccine-for-efficient-induction-of-cytotoxic-and-t-helper-responses
#2
Koen van der Maaden, Jeroen Heuts, Marcel Camps, Maria Pontier, Anton Terwisscha van Scheltinga, Wim Jiskoot, Ferry Ossendorp, Joke Bouwstra
Recent studies have shown that intradermal vaccination has great potential for T cell-mediated cancer immunotherapy. However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a digitally controlled hollow microneedle injection system (DC-hMN-iSystem) with an ultra-low dead volume was developed to perform micro-injections (0.25-10μL) into skin in an automated manner. A synthetic long peptide derived from human papilloma virus formulated in cationic liposomes, which was used as a therapeutic cancer vaccine, was administered intradermally by using the DC-hMN-iSystem...
January 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27979747/dna-vaccination-for-cervical-cancer-a-novel-technology-platform-of-rala-mediated-gene-delivery-via-polymeric-microneedles
#3
Ahlam A Ali, Cian M McCrudden, Joanne McCaffrey, John W McBride, Grace Cole, Nicholas J Dunne, Tracy Robson, Adrien Kissenpfennig, Ryan F Donnelly, Helen O McCarthy
HPV subtypes (16, 18) are associated with the development of cervical cancer, with oncoproteins E6 and E7 responsible for pathogenesis. The goal of this study was to evaluate our 'smart system' technology platform for DNA vaccination against cervical cancer. The vaccination platform brings together two main components; a peptide RALA which condenses DNA into cationic nanoparticles (NPs), and a polymeric polyvinylpyrrolidone (PVP) microneedle (MN) patch for cutaneous delivery of the loaded NPs. RALA condensed E6/E7 DNA into NPs not exceeding 100nm in diameter, and afforded the DNA protection from degradation in PVP...
April 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/25785935/vaccination-with-human-papillomavirus-pseudovirus-encapsidated-plasmids-targeted-to-skin-using-microneedles
#4
Rhonda C Kines, Vladimir Zarnitsyn, Teresa R Johnson, Yuk-Ying S Pang, Kizzmekia S Corbett, John D Nicewonger, Anu Gangopadhyay, Man Chen, Jie Liu, Mark R Prausnitz, John T Schiller, Barney S Graham
Human papilloma virus-like particles (HPV VLP) serve as the basis of the current licensed vaccines for HPV. We have previously shown that encapsidation of DNA expressing the model antigen M/M2 from respiratory syncytial virus (RSV) in HPV pseudovirions (PsV) is immunogenic when delivered intravaginally. Because the HPV capsids confer tropism for basal epithelium, they represent attractive carriers for vaccination targeted to the skin using microneedles. In this study we asked: 1) whether HPV16 VLP administered by microneedles could induce protective immune responses to HPV16 and 2) whether HPV16 PsV-encapsidated plasmids delivered by microneedles could elicit immune responses to both HPV and the antigen delivered by the transgene...
2015: PloS One
https://www.readbyqxmd.com/read/19175177/-the-effect-of-hpv16e7-dna-vaccine-transdermal-delivery-with-microneedle-array
#5
Hui Gao, Jin-Chun Pan, Bing Chen, Zheng-Feng Xue, Hou-Da Li
OBJECTIVE: To study the effects of DNA vaccine transdermal delivery with microneedle array. METHODS: The pcDNA3.1-HPV16E7 recombinant vector acting as gene vaccine was established. The infiltration quantity of pcDNA3.1-HPV16E7 getting across the microchannels generated by microneedle arrays in vitro was observed. 30 BALB/c mice were divided into 3 groups (experimental group, in vain plasmid group, negative control). Each group had 10 mice. Then immunized BALB/c mice with a dose of 200 microg with microneedle array every two weeks...
September 2008: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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