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https://www.readbyqxmd.com/read/28263215/pituitary-adenoma-recurrence-suspected-on-central-hyperthyroidism-despite-empty-sella-and-confirmed-by-68-ga-dota-toc-pet-ct
#1
Mathieu Gauthé, Julie Sarfati, Nathalie Bourcigaux, Sophie Christin-Maitre, Jean-Noël Talbot, Françoise Montravers
Thyrotropin-secreting pituitary adenomas are very rare tumors, known to present overexpression of somatostatin receptor subtype 2 and which may consequently demonstrate abnormal uptake on Ga-DOTA-TOC PET/CT. A 67-year-old woman with a history of operated pituitary macroadenoma presented with symptoms of hyperthyroidism including a large goiter. Her serum thyroid hormone levels were in favor of central hyperthyroidism. Pituitary MRI depicted an empty sella but visualized an ambiguous lesion centered on the left sphenoidal sinus...
March 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195748/imaging-features-of-idiopathic-intracranial-hypertension-in-children
#2
Alexander J P W Hartmann, Bruno P Soares, Beau B Bruce, Amit M Saindane, Nancy J Newman, Valérie Biousse, Jason H Peragallo
Magnetic resonance imaging (MRI) signs of elevated intracranial pressure and idiopathic intracranial hypertension have been well characterized in adults but not in children. The MRIs of 50 children with idiopathic intracranial hypertension and 46 adults with idiopathic intracranial hypertension were reviewed for optic nerve head protrusion, optic nerve head enhancement, posterior scleral flattening, increased perioptic cerebrospinal fluid, optic nerve tortuosity, empty or partially empty sella, tonsillar herniation, enlargement of Meckel's cave meningoceles, and transverse venous sinus stenosis(TSS)...
January 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28129900/-atypical-and-rare-cardiac-revelation-about-sheehan-s-syndrome-a-report-of-three-cases
#3
N Bouznad, G El Mghari, M El Hattaoui, N El Ansari
Sheehan syndrome is a potentially serious complication in the postpartum period corresponding to ischemic necrosis of the anterior pituitary related to postpartum haemorrhage. We report three original observations showing an unusual mode of revelation of this syndrome. The first observation is that of a 46-year-old patient admitted initially to resuscitation for a recovered cardiorespiratory arrest, severe hypoglycemia and profound hyponatremia. The second is that of a 45-year-old patient, admitted for recurrent cardiac tamponade after pericardial and pleural puncture and pericardial drainage; clinical survey found signs of slight panhypopituitarism...
January 24, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28089836/delayed-csf-rhinorrhea-after-gamma-knife-radiosurgery-with-or-without-preceding-transsphenoidal-resection-for-pituitary-pathology
#4
Avital Perry, Christopher S Graffeo, William R Copeland, Kathryn M Van Abel, Matthew L Carlson, Bruce E Pollock, Michael J Link
BACKGROUND: Skull base cerebrospinal fluid (CSF) leak after gamma knife radiosurgery (GKRS) is a very rare complication. In patients who were treated with both GKRS and transsphenoidal resection (TSR) for pituitary lesions, early CSF leak occurs at a comparable rate to the general TSR population (4%). Delayed CSF leak occurring more than a year after TSR, GKRS, or dual therapy, is exceedingly rare. METHODS: Retrospective chart review and review of the literature RESULTS: We present two cases of delayed CSF leak following GKRS to treat pituitary adenoma...
January 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28018694/anterior-hypopituitarism-and-treatment-response-in-hunter-syndrome-a-comparison-of-two-patients
#5
Munier A Nour, Paola Luca, David Stephure, Xing-Chang Wei, Aneal Khan
Hypopituitarism is a clinically important diagnosis and has not previously been reported in Hunter syndrome. We contrast two cases with anatomic pituitary anomalies: one with anterior panhypopituitarism and the other with intact pituitary function. Patient 1, a 10-year-old boy with Hunter syndrome, was evaluated for poor growth and an ectopic posterior pituitary gland. Endocrine testing revealed growth hormone (GH) deficiency, secondary adrenal insufficiency, and tertiary hypothyroidism. An improvement in growth velocity with hormone replacement (GH, thyroxine, and corticosteroid) was seen; however, final adult height remained compromised...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27967223/visual-vignettes-persistent-headaches-with-apparent-empty-sella-syndrome
#6
Jeyakantha Ratnasingam, Kheng Chiew Chooi, Syahrizan Samsuddin, Sharmila Paramasivam, Luqman Ibrahim, Lee Ling Lim, Alexander Tan, Shireene Vethakkan
No abstract text is available yet for this article.
December 14, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27918153/enlargement-of-meckel-s-cave-in-patients-with-spontaneous-cerebrospinal-fluid-leaks
#7
Geoffrey P Aaron, Elisa Illing, Zachary Lambertsen, Miles Ritter, Erik H Middlebrooks, Joel Cure, Do-Yeon Cho, Kristen O Riley, Bradford A Woodworth
BACKGROUND: Spontaneous cerebrospinal fluid (CSF) leaks have imaging findings consistent with chronically elevated intracranial pressure, such as empty sella. Meckel's cave is a CSF-filled space that houses the trigeminal ganglion at the cranial base. Our objective in this study was to evaluate "dilated" Meckel's cave as a radiologic sign in patients with elevated intracranial pressure spontaneous CSF leaks and compare the dimensions with those from a control cohort. METHODS: Meckel's cave dimensions were measured in patients with spontaneous CSF leaks and documented elevated intracranial pressure...
December 5, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27809892/spontaneous-cerebrospinal-fluid-leak-of-the-sphenoid-sinus-mimicking-allergic-rhinitis-and-managed-successfully-by-a-ventriculoperitoneal-shunt-a-case-report
#8
Youssef Darouassi, Mohamed Mliha Touati, Mehdi Chihani, Ali Akhaddar, Haddou Ammar, Brahim Bouaity
BACKGROUND: Spontaneous cerebrospinal fluid leaks are rare but may lead to confusion with other diseases in patients without history of trauma. We report a rare case unusual for two reasons. First, our patient was put under antiallergic medication for months before the diagnosis of spontaneous cerebrospinal fluid leak of the sphenoid sinus. Second, our patient was managed successfully by a ventriculoperitoneal shunt. CASE PRESENTATION: Our patient was a nonobese 49-year-old Arab man without history of trauma or surgery who presented with rhinorrhea...
November 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27757566/tectal-glioma-presenting-with-clinical-triad-of-obesity-amenorrhea-and-central-cord-syndrome-with-radiological-pentad-of-hydrocephalus-empty-sella-suprapineal-diverticula-chiari-and-syrinx
#9
Sivashanmugam Dhandapani, Madhivanan Karthigeyan, Sushanta K Sahoo, Vivek Gupta
BACKGROUND: Tectal gliomas (TG) are slow-growing tumors and generally present with features of increased intracranial pressure. CASE DESCRIPTION: We describe an unusual case of a young girl who presented with clinical triad of obesity, primary amenorrhea and central cord syndrome. The radiology unveiled a pentad of hydrocephalus, empty sella, suprapineal recess diverticulum, secondary Chiari malformation and cervical syringomyelia, masking a relatively obscure tectal plate glioma...
February 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#10
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27642481/-etiological-diagnosis-of-central-diabetes-insipidus-about-41-cases
#11
Fatma Chaker, Melika Chihaoui, Meriem Yazidi, Hedia Slimane
The occurrence of polyuria-polydipsia syndrome with hypotonic urine requires careful diagnostic strategy. This study aims to evaluate diagnostic modalities for central diabetes insipidus. We conducted a retrospective study of 41 cases with central diabetes insipidus (CDI). Data were collected at the Department of Endocrinology, University Hospital La Rabta, Tunis, from 1990 to 2013. We identified the circumstances for detecting CDI, the abnormalities in anterior pituitary assessment and pituitary imaging. CDI occurred in the postoperative period in 20 patients...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27608705/extra-pontine-myelinolysis-in-a-case-of-pan-hypopituitarism-due-to-empty-sella-syndrome
#12
Vishal Anand Gupta, Niteen Karnik, Manish Itolikar, Ketan Vekariya
Rapid correction of hyponatremia is known to cause central pontine myelinolysis (CPM). It may concurrently involve other areas of brain as well, referred as extra-pontine myelinolysis (EPM). Isolated EPM however is a very rare occurrence. We present a case of EPM where the hyponatremia was secondary to hypothyroidism due to empty sella syndrome. Chronic hyponatremia should always be corrected slowly to avoid such osmotic myelinolysis syndromes (OMS).
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27585209/update-on-the-evaluation-of-pediatric-idiopathic-intracranial-hypertension
#13
REVIEW
Aubrey L Gilbert, Gena Heidary
PURPOSE OF REVIEW: Papilledema associated with idiopathic intracranial hypertension (IIH) may result in irreversible, progressive visual loss. The development of tools for the evaluation of pediatric patients with IIH is particularly relevant as many patients may not be able to comply with the detailed clinical evaluation utilized in adults for the treatment and management of this disease. The purpose of this review is to summarize relevant articles on the diagnostic tools used in evaluation and management of pediatric IIH...
November 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27468406/ectopic-acromegaly-arising-from-a-pituitary-adenoma-within-the-bony-intersphenoid-septum-of-a-patient-with-empty-sella-syndrome
#14
Audrey E Arzamendi, Kiarash Shahlaie, Richard E Latchaw, Mirna Lechpammer, Hasmik Arzumanyan
OBJECTIVE: To describe the work-up and treatment of rare ectopic acromegaly caused by a biopsy-proven somatotroph pituitary adenoma located within the bony intersphenoid septum of a patient with empty sella syndrome (ESS). METHODS: We report the presentation, clinical course, diagnostic work-up, and lesion localization and treatment challenges encountered in a 55-year-old patient, with a brief review of relevant literature. RESULTS: A 55-year-old African-American man presented with acromegaly and ESS...
July 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27464418/lhx4-gene-alterations-patient-report-and-review-of-the-literature
#15
REVIEW
Zoran Gucev, Velibor Tasic, Dijana Plaseska-Karanfilska, Marina Krstevska Konstantinova, Ana Stamatova, Marija Dimishkovska, Nevenka Laban, Momir Polenakovic
LHX4 mutations are rare in combined pituitary hormone deficiency, and even rarer in isolated GHD. We describe a 14 years old boy who was referred for investigation of short stature. Convergent strabismus, nystagmus was present. At the age of 5 years his gait was unstable. A progressive myopathy ensued. Tests of pituitary reserve showed partial IGHD (8.2 ng/ml). Other pituitary hormones were within normal range. Muscle biopsy showed congenital myopathy of undefined etiology. MRI of the brain revealed the empty sella syndrome...
June 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/27452372/testosterone-undecanoate-improves-lipid-profile-in-patients-with-type-1-diabetes-and-hypogonadotrophic-hypogonadism
#16
RANDOMIZED CONTROLLED TRIAL
Juan J Chillarón, Mercè Fernández-Miró, Mercè Albareda, Sara Fontserè, Cristina Colom, Lluís Vila, Juan Pedro-Botet, Juana A Flores Le-Roux
Testosterone deficiency (Td) has been associated with the metabolic syndrome. Few studies have evaluated this condition in type 1 diabetes (T1D). The primary aim of this study was to evaluate the effectiveness of testosterone undecanoate (TU) on insulin sensitivity, glycemic control, anthropometric parameters, blood pressure and lipid profile in patients with Td and T1D. We performed a randomized placebo-controlled multicenter study. INCLUSION CRITERIA: a) age ≥ 18 years; b) autoimmune diabetes; c) Td (total testosterone <10 nmol/L or calculated free testosterone <225 pmol/L and low/normal LH; d) ability to sign informed consent; e) comply with the study protocol...
September 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27408609/sellar-reconstruction-without-intrasellar-packing-after-endoscopic-surgery-of-pituitary-macroadenomas-is-better-than-its-reputation
#17
Mostafa Ismail, Abd Alla Fares, Balegh Abdelhak, Jean D'Haens, Olaf Michel
OBJECTIVES: Sellar reconstruction with intrasellar packing following endoscopic resection of pituitary macroadenomas remains a subject of clinical and radiological discussion particularly, when an intraoperative cerebrospinal fluid (CSF) leakage is absent. This study was conducted to contribute our experience with sellar reconstruction after a standard endoscopic surgery of pituitary macroadenomas without intraoperative CSF leakage to the ongoing discussion between techniques with and without intrasellar packing...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27394707/cabergoline-treatment-for-recurrent-cushing-s-disease-during-pregnancy
#18
Afif Nakhleh, Leonard Saiegh, Maria Reut, Mohammad Sheikh Ahmad, Irit Wirsansky Pearl, Carmela Shechner
OBJECTIVE: Cushing's disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing's disease. Evolving data concerning the safety of cabergoline use during pregnancy show no significant increase in the rate of complications during pregnancy or the postnatal period...
July 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27335524/psychosis-in-secondary-empty-sella-syndrome-following-a-russell-s-viper-bite
#19
Badr Ratnakaran, Varghese P Punnoose, Soumitra Das, Arjun Kartha
Hypopituitarism can present with psychiatric symptoms. We report a unique case of psychosis in clear consciousness in a case of hypopituitarism due to the secondary empty sella syndrome following a Russell's viper bite which was untreated and presented with psychotic symptoms for past 13 years following the snake bite. After the diagnosis of psychosis due to hypopituitarism was made, the patient was treated with levothyroxine and prednisolone supplements and his psychotic symptoms subsided without any psychotropic drugs...
May 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27295175/a-modification-of-endoscopic-endonasal-approach-for-management-of-encephaloceles-in-sphenoid-sinus-lateral-recess
#20
M N El-Tarabishi, S A Fawaz, S M Sabri, M M El-Sharnobi, Ahmed Sweed
Spontaneous cerebrospinal fluid leak with meningoencephaloceles in sphenoid sinus lateral recess is challenging. Transnasal visualization of this area is difficult, especially when large pneumatization is present. External approaches to this region involve aggressive surgery and are often associated with significant morbidity. The aim of this study is to assess the real effectiveness of a modification of the endoscopic endonasal approach for their management. This is a prospective case series study and was conducted at Otolaryngology department, Ain Shams University Hospitals, Cairo, Egypt...
December 2016: European Archives of Oto-rhino-laryngology
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