Aniqa Shahid, Signe MacLennan, Bradley R Jones, Hanwei Sudderuddin, Zhong Dang, Kyle Cobarrubias, Maggie C Duncan, Natalie N Kinloch, Michael J Dapp, Nancie M Archin, Margaret A Fischl, Igho Ofotokun, Adaora Adimora, Stephen Gange, Bradley Aouizerat, Mark H Kuniholm, Seble Kassaye, James I Mullins, Harris Goldstein, Jeffrey B Joy, Kathryn Anastos, Zabrina L Brumme
Characterizing the genetically diverse HIV sequences that persist in the reservoir despite antiretroviral therapy (ART) is critical to cure efforts. Our observations confirm that proviruses persisting in blood on ART, which are largely genetically defective, broadly reflect the extent of within-host HIV evolution pre-ART. Moreover, on-ART clonal expansion is not appreciably accompanied by the loss of distinct proviral lineages. In fact, on-ART proviral genetic composition remained stable in all but one participant, in whom, after 12 years on ART, proviruses dating to around near ART initiation had been preferentially eliminated...
January 12, 2024: Journal of Virology