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Thobois S

C Laurencin, T Danaila, E Broussolle, S Thobois
In 2000, a French consensus conference proposed guidelines for the treatment of Parkinson's disease (PD). Since then, new drugs have been concocted, new studies have been published and clinicians have become aware of some drug-induced adverse effects that were little known in the past. This has led us to reconsider the recommendations published 16 years ago. Thus, the aim of the present review is to present the recent data related to the different medications and non-pharmacological approaches available for PD, with a special focus on early-stage PD...
August 2016: Revue Neurologique
C Laurencin, L Rascle, F Cotton, C Grosset-Janin, E Bernard, C Depienne, S Vukusic, S Thobois
We describe a patient with SPG11 hereditary spastic paraplegia (HSP), who developed walking disorder in childhood. He presented three episodes of subacute gait disorders worsening between the age of 20 and 22 years. Brain and spinal MRI revealed multiple T2 hypersignal lesions, consistent with inflammatory lesions. Surprisingly, CSF analysis showed neither oligoclonal bands nor increased IgG index. He was dramatically improved by intravenous methylprednisolone. A relapsing-remitting multiple sclerosis (MS) was suspected...
June 2016: Revue Neurologique
S Thobois
No abstract text is available yet for this article.
March 2015: Movement Disorders: Official Journal of the Movement Disorder Society
Isabelle Rieu, Magaly Aya Kombo, Stéphane Thobois, Philippe Derost, Pierre Pollak, Jing Xie, Bruno Pereira, Marie Vidailhet, Pierre Burbaud, Jean Pascal Lefaucheur, Jean Jacques Lemaire, Patrick Mertens, Stephan Chabardes, Emmanuel Broussolle, Franck Durif
OBJECTIVE: To assess the efficacy of epidural motor cortex stimulation (MCS) on dystonia, spasticity, pain, and quality of life in patients with dystonia secondary to a focal basal ganglia (BG) lesion. METHODS: In this double-blind, crossover, multicenter study, 5 patients with dystonia secondary to a focal BG lesion were included. Two quadripolar leads were implanted epidurally over the primary motor (M1) and premotor cortices, contralateral to the most dystonic side...
January 14, 2014: Neurology
W M M Schuepbach, J Rau, K Knudsen, J Volkmann, P Krack, L Timmermann, T D Hälbig, H Hesekamp, S M Navarro, N Meier, D Falk, M Mehdorn, S Paschen, M Maarouf, M T Barbe, G R Fink, A Kupsch, D Gruber, G-H Schneider, E Seigneuret, A Kistner, P Chaynes, F Ory-Magne, C Brefel Courbon, J Vesper, A Schnitzler, L Wojtecki, J-L Houeto, B Bataille, D Maltête, P Damier, S Raoul, F Sixel-Doering, D Hellwig, A Gharabaghi, R Krüger, M O Pinsker, F Amtage, J-M Régis, T Witjas, S Thobois, P Mertens, M Kloss, A Hartmann, W H Oertel, B Post, H Speelman, Y Agid, C Schade-Brittinger, G Deuschl
BACKGROUND: Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease. METHODS: In this 2-year trial, we randomly assigned 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) to undergo neurostimulation plus medical therapy or medical therapy alone...
February 14, 2013: New England Journal of Medicine
S Thobois, B Ballanger, A Poisson, E Broussolle
Parkinson's disease is mainly considered as a motor disorder defined by a motor triad. However, various non-motor manifestations may be encountered in Parkinson's disease, including hyposmia, pain, fatigue, sleep disorders, cognitive and behavioral disorders. The pathophysiology of these signs is complex, not univocal and remains poorly understood. Functional imaging techniques either by positron emission tomography, single photon emission tomography or functional magnetic resonance imaging provide an invaluable opportunity to better understand the pathophysiology of these signs...
August 2012: Revue Neurologique
A Poisson, P Krack, S Thobois, C Loiraud, G Serra, C Vial, E Broussolle
The geste antagoniste is a voluntary maneuver that temporarily reduces the severity of dystonic posture or movements. It is a classical feature of focal and particularly cervical dystonia. However, the precise historical aspects of geste antagoniste still remain obscure. The goals of this review were (1) to clarify the origin of the geste antagoniste sign; (2) to identify the factors that led to its diffusion in the international literature; (3) to follow the evolution of that term across the twentieth century...
August 2012: Journal of Neurology
L Abouaf, M Panouillères, S Thobois, V Majerova, A Vighetto, D Pélisson, C Tilikete
INTRODUCTION: Voluntary or reactive saccades predominate in rapid eye movements. Their goal is to preserve an active and optimal visual perception of the environment. Saccades cannot be guided once launched. Oculomotor plasticity, or saccadic adaptation, is still partially unknown, in particular the role played by the basal ganglia. New neuro-ophthalmological rehabilitation techniques require understanding the neurophysiological basis and demonstrating the neuronal structures involved in this plasticity...
April 2012: Journal Français D'ophtalmologie
D Adamec, J Xie, A Poisson, E Broussolle, S Thobois
Xeroderma pigmentosum (XP) is an uncommon inherited dermatological disorder characterized by a high degree of skin photosensitivity with development of carcinomas at an early age. Neurological manifestations may be encountered in XP but few detailed descriptions have been provided. Here we describe a sister and a brother presenting chorea, dystonia, myoclonus, ataxia and polyneuropathy related to XP.
November 2011: Revue Neurologique
P Devic, G Androdias-Condemine, N Streichenberger, F Berger, J Honnorat, E Broussolle, S Thobois
No abstract text is available yet for this article.
January 2012: QJM: Monthly Journal of the Association of Physicians
S Thobois, C Ardouin, E Schmitt, E Lhommée, H Klinger, J Xie, C Lagrange, A Kistner, M Aya Kombo, V Fleury, A Poisson, V Fraix, E Broussolle, P Pollak, P Krack
INTRODUCTION: Behavioral changes in Parkinson's disease are complex and their pathophysiology is not yet fully understood. The dopaminergic system seems to play a major role and most of the behavioral disorders in Parkinson's disease can be classified into either hypodopaminergic if related to the disease itself or hyperdopaminergic if related to dopaminergic treatment. STATE OF THE ART: Subthalamic stimulation, which enables withdrawal of dopaminergic medication at an advanced stage in the disease, provides a model for the study of certain nonmotor, dopamine-sensitive symptoms...
October 2010: Revue Neurologique
E Bernard, E Broussolle, S Thobois
INTRODUCTION: Initial manifestations of Huntington's disease (HD) are varied and chorea is not always the first motor symptom. CASE REPORT: We report the case of a 44-year-old woman, with a family history of HD, who presented isolated head and upper limbs tremor for 4 years. Genetic testing confirmed the diagnosis of HD and no cause of secondary postural tremor was found. Propanolol was introduced with success. CONCLUSION: This kind of presentation is unusual and has mostly been reported in the juvenile form of HD...
October 2010: Revue Neurologique
J Gan, J Xie-Brustolin, H Gervais-Bernard, A E Vallet, E Broussolle, S Thobois
Head tremor is very unusual in Parkinson's disease (PD). Five PD patients presenting a head tremor during the disease evolution have recently been reported. Here we describe a 74 year-old woman with a pure head resting tremor. The tremor was responsive to levodopa and had a 4.7 Hz frequency. A [(123)I]FP-CIT SPECT imaging confirmed a reduction of tracer uptake in the right striatum consistent with PD, that should be confirmed by long-term follow-up.
April 15, 2009: Journal of the Neurological Sciences
E Lohmann, S Thobois, S Lesage, E Broussolle, S Tezenas du Montcel, M-J Ribeiro, P Remy, A Pelissolo, B Dubois, L Mallet, P Pollak, Y Agid, A Brice
OBJECTIVE: To establish phenotype-genotype correlations in early-onset Parkinson disease (EOPD), we performed neurologic, neuropsychological, and psychiatric evaluations in a series of patients with and without parkin mutations. BACKGROUND: Parkin (PARK2) gene mutations are the major cause of autosomal recessive parkinsonism. The usual clinical features are early-onset typical PD with a slow clinical course, an excellent response to low doses of levodopa, frequent treatment-induced dyskinesias, and the absence of dementia...
January 13, 2009: Neurology
S Thobois, P Remy
No abstract text is available yet for this article.
March 2008: Revue Neurologique
E Roze, E Apartis, F Clot, N Dorison, S Thobois, L Guyant-Marechal, C Tranchant, P Damier, D Doummar, N Bahi-Buisson, N André-Obadia, D Maltete, A Echaniz-Laguna, Y Pereon, Y Beaugendre, S Dupont, T De Greslan, C P Jedynak, G Ponsot, J C Dussaule, A Brice, A Dürr, M Vidailhet
OBJECTIVE: To clarify the clinical and neurophysiologic spectrum of myoclonus-dystonia patients with mutations of the SGCE gene. METHODS: We prospectively studied 41 consecutive patients from 22 families with documented mutations of the SGCE gene. The patients had a standardized interview, neurologic examination, and detailed neurophysiologic examination, including surface polymyography, long-loop C-reflex studies, and EEG jerk-locked back averaging. RESULTS: We noted a homogeneous electrophysiologic pattern of myoclonus of subcortical origin with short jerks (mean 95 msec, range 25 to 256 msec) at rest, during action, and during posture; there were no features of cortical hyperexcitability (specifically no abnormal C-reflex response and no short-latency premyoclonic potential on back-averaging studies)...
March 25, 2008: Neurology
B Ballanger, P Baraduc, E Broussolle, D Le Bars, M Desmurget, S Thobois
BACKGROUND: In patients with Parkinson's disease (PD), motor performance may be dramatically improved in urgent and stressful situations. OBJECTIVE: The aim of this PET H(2)(15)O study was to determine the changes in brain activation pattern related to this unconscious increase in motor speed observed in the context of urgency in patients with PD. METHODS: Eight right-handed patients with PD, who had been off medication for at least 12 hours, without tremor, were enrolled...
October 2008: Journal of Neurology, Neurosurgery, and Psychiatry
David W Carmichael, Serge Pinto, Patricia Limousin-Dowsey, Stephane Thobois, Philip J Allen, Louis Lemieux, Tarek Yousry, John S Thornton
We investigated safety issues and potential experimental confounds when performing functional magnetic resonance imaging (fMRI) investigations in human subjects with fully implanted, active, deep brain stimulation (DBS) systems. Measurements of temperature and induced voltage were performed in an in vitro arrangement simulating bilateral DBS during magnetic resonance imaging (MRI) using head transmit coils in both 1.5 and 3.0 T MRI systems. For MRI sequences typical of an fMRI study with coil-averaged specific absorption rates (SARs) less than 0...
August 15, 2007: NeuroImage
M Ulla, S Thobois, J-J Lemaire, A Schmitt, P Derost, E Broussolle, P-M Llorca, F Durif
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra...
December 2006: Journal of Neurology, Neurosurgery, and Psychiatry
F Godinho, S Thobois, M Magnin, M Guenot, G Polo, I Benatru, J Xie, A Salvetti, L Garcia-Larrea, E Broussolle, P Mertens
OBJECTIVES: 1 - To assess the anatomical localization of the active contacts of deep brain stimulation targeted to the subthalamic nucleus (STN) in Parkinson's disease patients. 2 - To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologically-defined borders of the STN and the stereotactic theoretical target. METHODS: Twenty-eight patients underwent bilateral high-frequency stimulation of the STN (HFS-STN)...
October 2006: Journal of Neurology
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