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https://www.readbyqxmd.com/read/27848162/characterizing-the-spectrum-of-right-ventricular-remodelling-in-response-to-chronic-training
#1
Marta Sitges, Beatriz Merino, Constatine Butakoff, Maria Sanz de la Garza, Carles Paré, Silvia Montserrat, Barbara Vidal, Manel Azqueta, Georgia Sarquella, Josep Antoni Gutierrez, Ramon Canal, Josep Brugada, Bart H Bijnens
The significance and spectrum of reduced right ventricular (RV) deformation, reported in endurance athletes, is unclear. To comprehensively analyze the cardiac performance at rest of athletes, especially focusing on integrating RV size and deformation to unravel the underlying triggers of this ventricular remodelling. Hundred professional male athletes and 50 sedentary healthy males of similar age were prospectively studied. Conventional echocardiographic parameters of all four chambers were obtained, as well as 2D echo-derived strain (2DSE) in the left (LV) and in the RV free wall with separate additional analysis of the RV basal and apical segments...
November 15, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27847200/reduction-of-atrial-fibrillation-by-tanshinone-iia-in-chronic-heart-failure
#2
Zhifeng He, Changzheng Sun, Yi Xu, Dezhi Cheng
The aim of the present study was to confirm the effect of Tanshinone IIA (TAN) on the prevention of AF in chronic heart failure (CHF), and to elucidate the underlying electrophysiological mechanisms for the antiarrhythmic effects of TAN at the level of the atrium in an experimental model of CHF. In 10 female rabbits, CHF was induced by rapid ventricular pacing, leading to a significant decrease in ejection fraction in the presence of a dilated left ventricle and atrial enlargement. Twelve rabbits were sham-operated and served as controls...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27844058/western-high-fat-diet-consumption-during-adolescence-increases-susceptibility-to-traumatic-stress-while-selectively-disrupting-hippocampal-and-ventricular-volumes
#3
Priya Kalyan-Masih, Julio David Vega-Torres, Christina Miles, Elizabeth Haddad, Sabrina Rainsbury, Mohsen Baghchechi, Andre Obenaus, Johnny D Figueroa
Psychological trauma and obesity co-occur frequently and have been identified as major risk factors for psychiatric disorders. Surprisingly, preclinical studies examining how obesity disrupts the ability of the brain to cope with psychological trauma are lacking. The objective of this study was to determine whether an obesogenic Western-like high-fat diet (WD) predisposes rats to post-traumatic stress responsivity. Adolescent Lewis rats (postnatal day 28) were fed ad libitum for 8 weeks with either the experimental WD diet (41...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27827800/quantification-of-cerebral-lateral-ventricular-volume-in-cats-by-low-and-high-field-mri
#4
Paulina Przyborowska, Zbigniew Adamiak, Yauheni Zhalniarovich
OBJECTIVES: The aim of this study was to evaluate variations in lateral ventricles in the examined feline population with the use of quantitative analysis methods to determine whether sex or body weight influenced the size of the ventricles, and to identify any significant differences in the results of low- and high-field MRI. METHODS: Twenty healthy European Shorthair cats, aged 1-3 years, with body weight of 2.85-4.35 kg, were studied. MRI of brain structures was performed in a low- and a high-field MRI system...
November 8, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27818454/vidarabine-an-anti-herpes-virus-agent-protects-against-the-development-of-heart-failure-with-relatively-mild-side-effects-on-cardiac-function-in-a-canine-model-of-pacing-induced-dilated-cardiomyopathy
#5
Takashi Nakamura, Takayuki Fujita, Megumi Kishimura, Kenji Suita, Yuko Hidaka, Wenqian Cai, Masanari Umemura, Utako Yokoyama, Masami Uechi, Yoshihiro Ishikawa
BACKGROUND: In heart failure patients, chronic hyperactivation of sympathetic signaling is known to exacerbate cardiac dysfunction. In this study, the cardioprotective effect of vidarabine, an anti-herpes virus agent, which we identified as a cardiac adenylyl cyclase inhibitor, in dogs with pacing-induced dilated cardiomyopathy (DCM) was evaluated. In addition, the adverse effects of vidarabine on basal cardiac function was compared to those of the β-blocker, carvedilol.Methods and Results:Vidarabine and carvedilol attenuated the development of pacing-induced systolic dysfunction significantly and with equal effectiveness...
November 5, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27807020/miliary-tuberculosis-in-an-immunocompetent-male-with-a-fatal-outcome
#6
Louise Dunphy, Elizabeth Keating, T Parke
A man aged 33 years, born in Nepal, but resident in the UK for 7 years presented to the emergency department with a 4-day history of general malaise, fever (temperature 38.6°C) and a non-productive cough. His medical history was unremarkable and no high-risk behaviour was identified. Clinical examination confirmed decreased air entry bilaterally with bibasal crackles. He was tachycardic, with a heart rate of 120 bpm. Further investigation with a 12-lead ECG confirmed supraventricular tachycardia (SVT) which was terminated with vagal manoeuvres...
November 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27806176/abrupt-onset-of-refractory-heart-failure-associated-with-light-chain-amyloidosis-in-hypertrophic-cardiomyopathy
#7
Benedetta Tomberli, Francesco Cappelli, Federico Perfetto, Iacopo Olivotto
Importance: The natural history of hypertrophic cardiomyopathy (HCM) is complex and may include progressive heart failure and severe left ventricular dysfunction. When disease progression is abrupt, however, other coexisting diseases should be ruled out. This may be difficult in the case of amyloidosis, which classically mimics HCM. Results: We present an example of severe clinical deterioration in a patient with HCM due to superimposed amyloid light-chain amyloidosis...
November 2, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27797350/ecg-case-of-the-month-heart-failure-in-a-man-from-chile
#8
D Luke Glancy, Glenn A Cochran, Frederick R Helmcke
A 49-year-old man visiting New Orleans from Chile comes to the hospital complaining of exertional dyspnea for 2 months with the more recent onset of ankle edema. He is a slender man with a blood pressure of 91/60 mmHg, crackles at both lung bases, and markedly distended neck veins. His cardiac rhythm is irregular. A soft murmur of mitral regurgitation and a soft S-3 are heard at the left ventricular apex. All four pedal pulses are easily palpable. Epigastric tenderness is noted on palpation; although the patient has a history of peptic ulcer disease, the tenderness is probably due to an enlarged left lobe of his liver, the result of hepatic congestion from his heart failure...
September 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27776714/assessment-for-pulmonary-artery-hypertension-using-clinical-and-echocardiographic-criteria-in-patients-with-systemic-sclerosis
#9
Nadera Methia, Samia Latreche, Omar Ait Mokhtar, Jean-Jacques Monsuez, Salim Benkhedda
BACKGROUND: Prognosis of systemic sclerosis (SSc) is affected by pulmonary artery hypertension (PAH). METHODS: Among 202 patients (mean age: 46.1 ± 13.3 years; 177 women) with SSc, those with a tricuspid regurgitation (TR) jet maximal velocity at 2D-echocardiography (2DE) < 2.8m/second were not considered at high risk for PAH, whereas those with a TR velocity >3m/second or between 2.8 and 3m/second and associated with dyspnea were. RESULTS: Among 22 patients at risk, 15 (mean age: 50...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27774273/reversible-transition-from-a-hypertrophic-to-a-dilated-cardiomyopathy
#10
Frank Spillmann, Uwe Kühl, Sophie Van Linthout, Fernando Dominguez, Felicitas Escher, Heinz-Peter Schultheiss, Burkert Pieske, Carsten Tschöpe
We report the case of a 17-year-old female patient with known hypertrophic cardiomyopathy and a Wolff-Parkinson-White syndrome. She came to our department for further evaluation of a new diagnosed dilated cardiomyopathy characterized by an enlargement of the left ventricle and a fall in ejection fraction. Clinically, she complained about atypical chest pain, arrhythmic episodes with presyncopal events, and dyspnea (NYHA III) during the last 6 months. Non-invasive and invasive examinations including magnetic resonance imaging, electrophysiological examinations, and angiography did not lead to a conclusive diagnosis...
June 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27751702/prognostic-value-of-right-ventricular-dysfunction-markers-for-serious-adverse-events-in-acute-normotensive-pulmonary-embolism
#11
Anthony J Weekes, Angela K Johnson, Daniel Troha, Gregory Thacker, Jordan Chanler-Berat, Michael Runyon
BACKGROUND: Right ventricular dysfunction (RVD) in pulmonary embolism (PE) has been associated with increased morbidity. Tools for RVD identification are not well defined. The prognostic value of RVD markers to predict serious adverse events (SAE) during hospitalization is unclear. OBJECTIVE: Prospectively compare the incidence of SAE in normotensive emergency department patients with PE based upon RVD by goal-directed echocardiography (GDE), cardiac biomarkers, and right-to-left ventricle ratio by computed tomography (CT)...
October 14, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27720201/undersized-mitral-annuloplasty-increases-strain-in-the-proximal-lateral-left-ventricular-wall
#12
Joe Luis Pantoja, Ashley E Morgan, Eugene A Grossi, Morten O Jensen, Jonathan W Weinsaft, Robert A Levine, Liang Ge, Mark B Ratcliffe
BACKGROUND: Recurrence of mitral regurgitation (MR) after undersized mitral annuloplasty (MA) for ischemic MR is as high as 60%, with the recurrence rate likely due to continued dilation of the left ventricle (LV). To better understand the causes of recurrent MR, we studied the effect of undersized MA on strain in the LV wall. We hypothesize that the acute change in ventricular shape induced by MA will cause increased strain in regions nearest the mitral valve. METHODS: Finite element models were previously reported, based on cardiac magnetic resonance images of 5 sheep with mild to moderate ischemic MR...
October 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27694425/left-ventricular-apical-aneurysm-in-a-cat-with-primary-cardiomyopathy
#13
C Ramírez-Hernández, A Barbosa-Quintana, R Ramírez-Romero
A 13-year-old female Persian cat died suddenly after severe respiratory distress. At necropsy, the changes were compatible with congestive heart failure. The heart was enlarged with a flabby and puckered sac-like aneurysm at the apex of the left ventricle. The apical zone showed a thin muscular wall arising from the free wall of the left ventricle connected to a bulged saccular area through a wide communication. Microscopically, the wall of the aneurysm was composed of fibrous connective tissue with neovascularization and sparse atrophied myocardial cells at the margins...
September 30, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27692224/exercise-induced-atrial-remodeling-the-forgotten-chamber
#14
Antonello D'Andrea, Eduardo Bossone, Juri Radmilovic, Lucia Riegler, Enrica Pezzullo, Raffaella Scarafile, Maria Giovanna Russo, Maurizio Galderisi, Raffaele Calabrò
Cardiac changes in athletes involve the left ventricle and atrium. Mild left atrial enlargement is common among competitive athletes, possibly a physiologic adaptation to exercise conditioning. The prevalence of this remodeling and the association with supraventricular arrhythmias has not been systematically addressed. Echocardiography screens for patients with disease involving the left atrium. New techniques like speckle tracking can recognize early atrial dysfunction and assess left atrial myocardial function in patients with either physiologic or pathologic left ventricular hypertrophy...
November 2016: Cardiology Clinics
https://www.readbyqxmd.com/read/27684832/abdominal-obesity-and-structure-and-function-of-the-heart-in-healthy-male-koreans-the-arirang-study
#15
Jung-Woo Son, Joong Kyung Sung, Jun-Won Lee, Young Jin Youn, Min-Soo Ahn, Sung Gyun Ahn, Byung-Su Yoo, Seung-Hwan Lee, Junghan Yoon, Sang Baek Koh, Jang-Young Kim
Although central obesity is a more powerful predictor of cardiovascular disease (CVD) than general obesity, there is limited information on structural and functional changes of the heart in central obesity. Therefore, we evaluated the association between abdominal obesity and geometric and functional changes of the heart in healthy males. A total of 1460 healthy males aged 40 to 70 years without known CVD from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population were included...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27683406/impedance-to-retrograde-and-forward-flow-in-chronic-mitral-regurgitation-and-the-physiology-of-a-double-outlet-ventricle
#16
William H Gaasch, Sachin P Shah, Sherif B Labib, Theo E Meyer
OBJECTIVE: Mitral regurgitation (MR) is generally characterised as exhibiting a 'low impedance leak into the left atrium'. This notion is widely accepted without measured impedance data. The aim of this study was to define the impedance to retrograde and forward blood flow and to examine hydraulic (pressure-volume) and mechanical (stress-shortening) function in chronic severe MR. METHODS: A mathematical model of a double outlet ventricle was developed and the ratio of retrograde to forward impedance was plotted over a wide range of regurgitant fraction (RF)...
September 28, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27665331/cardiac-evaluation-in-children-with-hemangiomas
#17
İlkay Erdoğan, Faik Sarıalioğlu
OBJECTIVE: Hemangiomas are tumors most commonly encountered in pediatric patients, and are frequently treated with propranolol. However, there are currently no standard methods for evaluating cardiac function in patients prior to propranolol treatment. The present study was designed to aid in the evaluation of pretreatment cardiac and effects of propranolol on vital signs in pediatric hemangioma patients. METHODS: A pediatric oncology specialist and a pediatric cardiology specialist examined all patients prior to initiation of propranolol treatment...
September 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27610717/morphometric-documentation-of-a-high-prevalence-of-left-ventricular-dilated-cardiomyopathy-in-both-clinically-normal-and-cyanotic-mature-commercial-broiler-breeder-roosters-with-comparisons-to-market-age-broilers
#18
Floyd D Wilson, Danny L Magee, Kelli H Jones, Erica Baravik-Munsell, Timothy S Cummings, Robert W Wills, Lanny W Pace
Previous studies documented the common occurrence of transitory cyanosis and echocardiographic aortic insufficiency in mature commercial broiler breeder roosters. During further investigations, we observed a high prevalence of hearts exhibiting extensive dilation of the left ventricle chamber compatible with dilated left ventricular cardiomyopathy present in both cyanotic and normal subpopulations. We conducted quantitative studies focused on documentation of cardiac ventricle parameters by using simple gross morphometric methods performed on formalin-fixed hearts obtained from both clinically normal roosters and those exhibiting variable transitory cyanosis, echocardiographic aortic insufficiency, or both...
September 2016: Avian Diseases
https://www.readbyqxmd.com/read/27554423/qrs-complex-waveform-indicators-of-ventricular-activation-slowing-simulation-studies
#19
Ljuba Bacharova, Vavrinec Szathmary, Jana Svehlikova, Anton Mateasik, Milan Tysler
Diffuse or regional activation slowing in ventricular myocardium can result from different cardiac pathologies, such as left ventricular hypertrophy, ischemia or fibrosis. Altered ventricular activation sequence leads to deformations of the activation front and consequently to the changes in the QRS complex. Using a computer model we simulated the effect of slowed ventricular activation on the QRS waveform with a special interest in ECG changes which reproduce the ECG criteria of left ventricular hypertrophy (ECG-LVH)...
August 5, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27547471/noncompaction-and-dilated-cardiomyopathy-in-a-patient-with-schizophrenia
#20
Josef Finsterer, Claudia Stöllberger
Objectives. Psychosis and left ventricular hypertrabeculation (or noncompaction) (LVHT) have not been described in the same patient. Here we report a patient with a long-term history of schizophrenia who was later diagnosed with dilated cardiomyopathy (dCMP) and LVHT. Case Report. A 47-year-old Caucasian male developed nondifferentiated schizophrenia at the age of 26 y. Since the age of 33 y he was regularly drinking alcohol. At the age of 47 y he developed heart failure. Transthoracic echocardiography showed an enlarged left ventricle, reduced systolic function, and surprisingly LVHT in the apical segment...
2016: Case Reports in Cardiology
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