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https://www.readbyqxmd.com/read/28329164/large-animal-model-of-functional-tricuspid-regurgitation-in-pacing-induced-end-stage-heart-failure
#1
Marcin Malinowski, Alistair G Proudfoot, David Langholz, Lenora Eberhart, Michael Brown, Hans Schubert, Jeremy Wodarek, Tomasz A Timek
OBJECTIVES: Functional tricuspid regurgitation (FTR) is common in patients with advanced heart failure and frequently complicates left ventricular assist device implantation yet remains poorly understood. We set out to establish large animal model of FTR that could serve as a research platform to investigate the pathogenesis of FTR associated with end-stage heart failure. METHODS: : Through right thoracotomy, ten adult sheep underwent implantation of pacemaker with epicardial LV lead, five sonomicrometry crystals on the right ventricle, and left and right ventricular telemetry pressure sensors during a beating heart off-pump procedure...
February 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28326451/application-of-endoscopic-third-ventriculostomy-for-treating-hydrocephalus-correlated-chiari-type-i-malformation-in-a-single-chinese-neurosurgery-centre
#2
Yiping Wu, Chuzhong Li, Xuyi Zong, Xinsheng Wang, Songbai Gui, Caiping Gu, Yazhuo Zhang
The correlation between hydrocephalus and Chiari type I malformation (CIM) has been debated since Chiari's first descriptions of CIM but some studies have shown that CIM and hydrocephalus (HCP) could cause symptoms/disease of each other or vice versa. Recent research has found that treatment focused on hydrocephalus with ventricle enlargement also provides alleviation of CIM and even of syringomyelia. However, the lack of consensus among previous studies left unanswered the question of how endoscopic third ventriculostomy (ETV) addresses CIM and why it fails...
March 22, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28320172/neuropathological-findings-from-an-autopsied-case-showing-posterior-reversible-encephalopathy-syndrome-like-neuroradiological-findings-associated-with-premedication-including-tacrolimus-for-autologous-peripheral-blood-stem-cell-transplantation
#3
Yuichi Hayashi, Akio Kimura, Hiroshi Nakamura, Maya Mimuro, Yasushi Iwasaki, Akira Hara, Mari Yoshida, Takashi Inuzuka
Posterior reversible encephalopathy syndrome (PRES) is diagnosed based on neuroradiological findings. Typically, PRES is reversible and presents with a good outcome; however, fatal outcomes have been reported. We report an autopsied case showing PRES-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation in a 28-year-old woman with a 2-year history of acute myeloid sarcoma/acute myeloid leukemia. Neurological examination revealed disturbed consciousness, muscle weakness in all extremities, and bilaterally diminished tendon reflexes...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28295525/advantages-and-pitfalls-of-pocket-ultrasound-vs-daily-chest-radiography-in-the-coronary-care-unit-a-single-user-experience
#4
Colin T Phillips, Warren J Manning
BACKGROUND: Pocket ultrasonography may enhance patient diagnosis and care. We sought to assess pocket ultrasound in detecting common conditions in the coronary care unit (CCU) compared to portable daily chest radiography (CXR) and conventional transthoracic echocardiography (TTE). METHODS: An experienced pocket ultrasound user performed a pocket ultrasound examination for interstitial edema, pneumonia, central line seen in the right ventricle, pleural and pericardial effusions, left atrial enlargement, and cardiomegaly...
March 14, 2017: Echocardiography
https://www.readbyqxmd.com/read/28247428/predictors-and-prognostic-significance-of-atrial-fibrillation-developed-during-dobutamine-stress-echocardiography-a%C3%A2-propensity-score-matched-comparison
#5
Yuba Acharya, Sahil Agrawal, Junu Bhattarai, Vlad Cotarlan, Jamshid Shirani
AIMS: Atrial fibrillation (AF) uncommonly occurs during dobutamine stress echocardiography (DSE). We aimed to characterize the predictors and long-term prognostic significance of AF during DSE. METHODS: The clinical, echocardiographic, and outcome data of patients in sinus rhythm who developed AF during DSE were reviewed and compared to a propensity score-matched group of controls. RESULTS: Atrial fibrillation developed in 73 (1% of 7026) patients (age 70±10 years, 58% men)...
March 2017: Echocardiography
https://www.readbyqxmd.com/read/28238149/the-occurrence-of-atrial-fibrillation-in-dialysis-patients-and-its-association-with-left-atrium-volume-before-and-after-dialysis
#6
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Jacek Rysz
PURPOSE: Atrial fibrillation is a serious problem, especially in patients on dialysis. The prevalence of AF in this group of patients is higher than in general population and associated with increased mortality. The aim of this study was to assess the risk of the occurrence of atrial fibrillation related to intradialysis hypotension and left atrium volume enlargement associated with dialysis. The influence of dialysis session on: E/E', V LA, E/A, E', V RA and the width of inferior vena cava of RV was analyzed...
February 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28229989/prenatal-diagnosis-of-right-dominant-heart-in-fetuses-a-tertiary-center-experience-over-a-7-year-period
#7
Juan Feng, Mei Zhu, Hao Liang, Qiao Li
BACKGROUND: Right dominant heart (RDH) in fetuses can occur with a number of cardiac as well as noncardiac anomalies. Analysis of the enlargement of the right cardiac chamber in the fetus remains a major challenge for sonographers and echocardiographers. The aim of this study was to report the experience with prenatal diagnosis of RDH in the fetuses over a 7-year period. METHODS: Fetuses with prenatal diagnosis of RDH from July 2009 to July 2016 were evaluated in two different categories: according to the gestational age, Group I (n = 154, second trimester) and Group II (n = 298, third trimester); and according to the fetal echocardiography diagnosis, Group A (n = 452, abnormal cardiac structure) and Group B (n = 90, normal cardiac structure)...
March 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28156163/post-infarct-sleep-disruption-and-its-relation-to-cardiac-remodeling-in-a-rat-model-of-myocardial-infarction
#8
Marjan Aghajani, Mahdieh Faghihi, Alireza Imani, Mohammad Reza Vaez Mahdavi, Abbas Shakoori, Tayebeh Rastegar, Hoda Parsa, Saman Mehrabi, Fatemeh Moradi, Ehsan Kazemi Moghaddam
Sleep disruption after myocardial infarction (MI) by affecting ubiquitin-proteasome system (UPS) is thought to contribute to myocardial remodeling and progressive worsening of cardiac function. The aim of current study was to test the hypothesis about the increased risk of developing heart failure due to experience of sleep restriction (SR) after MI. Male Wistar rats (n = 40) were randomly assigned to four experimental groups: (1) Sham, (2) MI, (3) MI and SR (MI + SR) (4) Sham and SR (Sham + SR). MI was induced by permanent ligation of left anterior descending coronary artery...
February 3, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28155693/numerical-simulation-of-closure-performance-for-neo-aortic-valve-for-arterial-switch-operation
#9
Zhaoyong Gu, Youlian Pan, Aike Qiao, Xingjian Hu, Nianguo Dong, Xiaofeng Li, Yinglong Liu, Deguang Shang
BACKGROUND: Modeling neo-aortic valve for arterial switch surgical planning to simulate the neo-aortic valve closure performance. METHODS: We created five geometrical models of neo-aortic valve, namely model A, model B, model C, model D and model E with different size of sinotubular junction or sinus. The nodes at the ends of aorta and left ventricle duct fixed all the degrees of freedom. Transvalvular pressure of normal diastolic blood pressure of 54 mmHg was applied on the neo-aortic valve cusps...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28149413/left-atrial-enlargement-in-young-high-level-endurance-athletes-another-sign-of-athlete-s-heart
#10
Wojciech Król, Ilona Jędrzejewska, Marcin Konopka, Krystyna Burkhard-Jagodzińska, Andrzej Klusiewicz, Andrzej Pokrywka, Jolanta Chwalbińska, Dariusz Sitkowski, Mirosław Dłużniewski, Artur Mamcarz, Wojciech Braksator
Enlargement of the left atrium is perceived as a part of athlete's heart syndrome, despite the lack of evidence. So far, left atrial size has not been assessed in the context of exercise capacity. The hypothesis of the present study was that LA enlargement in athletes was physiological and fitness-related condition. In addition, we tried to assess the feasibility and normal values of left atrial strain parameters and their relationship with other signs of athlete's heart. The study group consisted of 114 international-level rowers (17...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28065377/prognostic-value-of-computed-tomography-pulmonary-angiography-indices-in-patients-with-cancer-related-pulmonary-embolism-data-from-a-multicenter-cohort-study
#11
MULTICENTER STUDY
Juana María Plasencia-Martínez, Alberto Carmona-Bayonas, David Calvo-Temprano, Paula Jiménez-Fonseca, Francisco Fenoy, Mariana Benegas, Marcelo Sánchez, Carme Font, Diego Varona, David Martínez de la Haza, Jesús Pueyo, Mercè Biosca, Maite Antonio, Carmen Beato, Pilar Solís, Laura Fáez, Irma de Al Haba, Susana Hernández-Muñiz, Olga Madridano, Mar Martín, Eduardo Castañón, Avinash Ramchandani, Pablo Marchena, Manuel Sánchez-Cánovas, María Ángeles Vicente, Mari José Martínez, Ángela Fernández-Plaza, Lourdes Martínez-Encarnación, Alejandro Puerta, Ángel Domínguez, Daniel Rodríguez, Gema Marín, Remedios Otero, Fernando Sánchez-Lasheras, Vicente Vicente
OBJECTIVE: To analyze the prognostic value of pulmonary artery obstruction versus right-ventricle (RV) dysfunction radiologic indices in cancer-related pulmonary embolism (PE). METHODS: We enrolled 303 consecutive patients with paraneoplastic PE, evaluated by computed tomography pulmonary angiography (CTPA) between 2013 and 2014. The primary outcome measure was serious complications at 15days. Multivariate analyses were conducted by using binary logistic and robust regressions...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28056870/anti-n-methyl-d-aspartate-receptor-nmdar-antibody-encephalitis-presents-in-atypical-types-and-coexists-with-neuromyelitis-optica-spectrum-disorder-or-neurosyphilis
#12
Kaiyu Qin, Wenqing Wu, Yuming Huang, Dongmei Xu, Lei Zhang, Bowen Zheng, Meijuan Jiang, Cheng Kou, Junhua Gao, Wurong Li, Jinglin Zhang, Sumei Wang, Yanfei Luan, Chaoling Yan, Dan Xu, Xinmei Zheng
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases of anti-NMDAR encephalitis with incomplete forms, 3 cases of which were accompanied by neuromyelitis optica spectrum disorder or neurosyphilis respectively. CASE PRESENTATION: A 33-year-old man presented with dysarthria, movement disorder and occasional seizures...
January 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28054710/atypical-surface-ecg-complicating-the-diagnosis-of-bundle-branch-reentry-tachycardia
#13
Christopher Reithmann, Bernhard Herkommer, Thomas Remp, Michael Fiek
BACKGROUND: Typical left bundle branch block (LBBB) during ventricular tachycardia (VT) is a diagnostic criterion of bundle branch reentry tachycardia (BBRT) with activation of the right bundle in the anterograde direction. METHODS AND RESULTS: Eleven patients (seven male, 60 ± 12 years) with nonischemic cardiomyopathy (left ventricular ejection fraction 37 ± 16%) presenting with BBRT were successfully treated by ablation of the right bundle. Among them, five patients had atypical surface electrocardiograms (ECGs) differing from a typical LBBB during the VT...
February 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28013288/structural-cerebral-abnormalities-and-neurodevelopmental-status-in-single-ventricle-congenital-heart-disease-before-fontan-procedure
#14
Walter Knirsch, Kristina Nadine Mayer, Ianina Scheer, Ruth Tuura, Dietmar Schranz, Andreas Hahn, Kristina Wetterling, Ingrid Beck, Beatrice Latal, Bettina Reich
OBJECTIVES: Neonates with single ventricle congenital heart disease are at risk for structural cerebral abnormalities. Little is known about the further evolution of cerebral abnormalities until Fontan procedure. METHODS: Between August 2012 and July 2015, we conducted a prospective cross-sectional two centre study using cerebral magnetic resonance imaging (MRI) and neuro-developmental outcome assessed by the Bayley-III. Forty-seven children (31 male) were evaluated at a mean age of 25...
December 23, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28002328/chronic-disseminated-intravascular-coagulation-induced-by-left-atrial-thrombus-in-a-patient-with-giant-normal-heart-a-case-report
#15
Qianqian Shao, Ran Tian, Xu Zhang, Xin Gao, Jinzhi Lai, Zhuang Tian, Xiaowei Yan, Shuyang Zhang
INTRODUCTION: We herein describe a patient with chronic disseminated intravascular coagulation (DIC) induced by a giant thrombus in the left atrium.A 63-year-old woman was admitted to our hospital for evaluation of extensive mucocutaneous hemorrhage, especially at the sites of venipuncture, on May 21, 2015. Considering her long history of rheumatic heart disease and atrial fibrillation and her mitral valve replacement performed several years previously, we strongly suspected that the bleeding was closely related to postoperative over-anticoagulation of warfarin...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27848162/characterizing-the-spectrum-of-right-ventricular-remodelling-in-response-to-chronic-training
#16
Marta Sitges, Beatriz Merino, Constatine Butakoff, Maria Sanz de la Garza, Carles Paré, Silvia Montserrat, Barbara Vidal, Manel Azqueta, Georgia Sarquella, Josep Antoni Gutierrez, Ramon Canal, Josep Brugada, Bart H Bijnens
The significance and spectrum of reduced right ventricular (RV) deformation, reported in endurance athletes, is unclear. To comprehensively analyze the cardiac performance at rest of athletes, especially focusing on integrating RV size and deformation to unravel the underlying triggers of this ventricular remodelling. Hundred professional male athletes and 50 sedentary healthy males of similar age were prospectively studied. Conventional echocardiographic parameters of all four chambers were obtained, as well as 2D echo-derived strain (2DSE) in the left (LV) and in the RV free wall with separate additional analysis of the RV basal and apical segments...
November 15, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27847200/reduction-of-atrial-fibrillation-by-tanshinone-iia-in-chronic-heart-failure
#17
Zhifeng He, Changzheng Sun, Yi Xu, Dezhi Cheng
The aim of the present study was to confirm the effect of Tanshinone IIA (TAN) on the prevention of AF in chronic heart failure (CHF), and to elucidate the underlying electrophysiological mechanisms for the antiarrhythmic effects of TAN at the level of the atrium in an experimental model of CHF. In 10 female rabbits, CHF was induced by rapid ventricular pacing, leading to a significant decrease in ejection fraction in the presence of a dilated left ventricle and atrial enlargement. Twelve rabbits were sham-operated and served as controls...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27844058/western-high-fat-diet-consumption-during-adolescence-increases-susceptibility-to-traumatic-stress-while-selectively-disrupting-hippocampal-and-ventricular-volumes
#18
Priya Kalyan-Masih, Julio David Vega-Torres, Christina Miles, Elizabeth Haddad, Sabrina Rainsbury, Mohsen Baghchechi, Andre Obenaus, Johnny D Figueroa
Psychological trauma and obesity co-occur frequently and have been identified as major risk factors for psychiatric disorders. Surprisingly, preclinical studies examining how obesity disrupts the ability of the brain to cope with psychological trauma are lacking. The objective of this study was to determine whether an obesogenic Western-like high-fat diet (WD) predisposes rats to post-traumatic stress responsivity. Adolescent Lewis rats (postnatal day 28) were fed ad libitum for 8 weeks with either the experimental WD diet (41...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27827800/quantification-of-cerebral-lateral-ventricular-volume-in-cats-by-low-and-high-field-mri
#19
Paulina Przyborowska, Zbigniew Adamiak, Yauheni Zhalniarovich
OBJECTIVES: The aim of this study was to evaluate variations in lateral ventricles in the examined feline population with the use of quantitative analysis methods to determine whether sex or body weight influenced the size of the ventricles, and to identify any significant differences in the results of low- and high-field MRI. METHODS: Twenty healthy European Shorthair cats, aged 1-3 years, with body weight of 2.85-4.35 kg, were studied. MRI of brain structures was performed in a low- and a high-field MRI system...
November 8, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27818454/vidarabine-an-anti-herpes-virus-agent-protects-against-the-development-of-heart-failure-with-relatively-mild-side-effects-on-cardiac-function-in-a-canine-model-of-pacing-induced-dilated-cardiomyopathy
#20
Takashi Nakamura, Takayuki Fujita, Megumi Kishimura, Kenji Suita, Yuko Hidaka, Wenqian Cai, Masanari Umemura, Utako Yokoyama, Masami Uechi, Yoshihiro Ishikawa
BACKGROUND: In heart failure patients, chronic hyperactivation of sympathetic signaling is known to exacerbate cardiac dysfunction. In this study, the cardioprotective effect of vidarabine, an anti-herpes virus agent, which we identified as a cardiac adenylyl cyclase inhibitor, in dogs with pacing-induced dilated cardiomyopathy (DCM) was evaluated. In addition, the adverse effects of vidarabine on basal cardiac function was compared to those of the β-blocker, carvedilol.Methods and Results:Vidarabine and carvedilol attenuated the development of pacing-induced systolic dysfunction significantly and with equal effectiveness...
November 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
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