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https://www.readbyqxmd.com/read/27900388/data-driven-modeling-for-precision-medicine-in-pediatric-acute-liver-failure
#1
Ruben Zamora, Yoram Vodovotz, Qi Mi, Derek Barclay, Jinling Yin, Simon Horslen, David Rudnick, Kathleen M Loomes, Robert H Squires
Absence of early outcome biomarkers for Pediatric Acute Liver Failure (PALF) hinders medical and liver transplant decisions. We sought to define dynamic interactions among circulating inflammatory mediators to gain insights into PALF outcome sub-groups. Serum samples from 101 participants in the PALF study, collected over the first 7 days following enrollment, were assayed for 27 inflammatory mediators. Outcomes (Spontaneous survivors [S, n=61], Non-survivors [NS, n=12], and liver transplant patients [LTx, n=28]) were assessed at 21 days post-enrollment...
November 23, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27755215/fecal-hmgb1-reveals-microscopic-inflammation-in-adult-and-pediatric-patients-with-inflammatory-bowel-disease-in-clinical-and-endoscopic-remission
#2
Francesca Palone, Roberta Vitali, Salvatore Cucchiara, Maurizio Mennini, Alessandro Armuzzi, Daniela Pugliese, Renata DʼIncà, Brigida Barberio, Laura Stronati
BACKGROUND: Fecal high mobility group box 1 (HMGB1) has been suggested to be a novel noninvasive biomarker of gut inflammation. We aimed to assess the reliability of fecal HMGB1, compared with fecal calprotectin (FC), in detecting intestinal inflammation in pediatric and adult patients with inflammatory bowel disease (IBD) and to evaluate the accuracy of HMGB1 in identifying patients with IBD in clinical and endoscopic remission who still have histologic features of inflammation. METHODS: Stool samples from 85 children with IBD (49 Crohn's disease [CD] and 36 ulcerative colitis [UC] and 119 adults [57 Crohn's disease and 62 ulcerative colitis]) were analyzed for the study...
October 13, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27499050/high-mobility-group-box-1-and-tumor-growth-factor-%C3%AE-useful-biomarkers-in-pediatric-patients-receiving-peritoneal-dialysis
#3
Roberto Chimenz, Antonio Lacquaniti, Laura Colavita, Valeria Chirico, Claudia Fede, Michele Buemi, Carmelo Fede
BACKGROUND: Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role as precocious marker of peritoneum damage during peritonitis. Transforming growth factor (TGF)-β was correlated with peritoneal transport characteristics. METHODS: Six patients, treated by ambulatory PD, were enrolled...
August 8, 2016: Renal Failure
https://www.readbyqxmd.com/read/26693068/necrostatin-1-reduces-intestinal-inflammation-and-colitis-associated-tumorigenesis-in-mice
#4
Zhen-Yu Liu, Bo Wu, Yun-Shan Guo, Ying-Hui Zhou, Zhi-Guang Fu, Bao-Qing Xu, Jiang-Hua Li, Lin Jing, Jian-Li Jiang, Juan Tang, Zhi-Nan Chen
Necroptosis, a novel form of programmed cell death, was recently shown to be strongly associated with intestinal inflammation in mice and in pediatric patients with inflammatory bowel disease (IBD). Persistent inflammation of the colon is an important risk factor for colorectal cancer. Necrostatin-1 (Nec-1), known as a specific inhibitor of necroptosis, through preventing the receptor-interacting protein (RIP) 1 and RIP3 interaction. In the present study, the anti-inflammatory and antitumorigenic efficacy of necrostatin-1 was studied in mouse models of colitis and colitis-associated cancer (CAC)...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/25229960/-diagnostic-value-of-high-mobility-group-box-1-for-acute-appendicitis-in-children
#5
Jian-Fen Hu, Jiang-Yan Wu, Lin Zhang, Long-Gui Yang, Cai-Xia Long
OBJECTIVE: To evaluate the value of high mobility group box 1(HMGB1) in the diagnosis of pediatric acute appendicitis. METHODS: The children with acute abdomen who had a diagnosis of suspected acute appendicitis between January and July 2013 and 25 healthy children were enrolled in this study. Serum HMGB1 levels were measured using ELISA on admission. The patients were classified into 2 groups according to surgery confirmation or pathological results: appendicitis (n=28) and non-appendicitis (n=35)...
September 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/24927058/plasma-high-mobility-group-box-1-protein-reflects-fibrosis-in-pediatric-nonalcoholic-fatty-liver-disease
#6
Anna Alisi, Valerio Nobili, Sara Ceccarelli, Nadia Panera, Cristiano De Stefanis, Rita De Vito, Roberta Vitali, Giorgio Bedogni, Clara Balsano, Salvatore Cucchiara, Laura Stronati
Non-alcoholic fatty liver disease (NAFLD) affects 3-12% of the general pediatric population. HMGB1 protein is presently considered a potent inflammatory mediator in several liver diseases, even if its role in NAFLD is still unknown in clinical studies. Here we investigated the relationships between circulating HMGB1, TGF-β and MCP-1 and liver damage in pediatric NAFLD. HMGB1, TGF-β and MCP-1 plasma levels were measured in 110 obese children with biopsy-proven NAFLD and 40 age-matched obese controls. HMGB1, TGF-β and MCP-1, ALT, AST and cholesterol plasma levels were significantly higher in NAFLD than in control children...
July 2014: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/24809802/high-mobility-group-box-1-hmgb1-in-childhood-from-bench-to-bedside
#7
REVIEW
Valeria Chirico, Antonio Lacquaniti, Vincenzo Salpietro, Caterina Munafò, Maria Pia Calabrò, Michele Buemi, Teresa Arrigo, Carmelo Salpietro
UNLABELLED: High-mobility group box protein 1 (HMGB1) is a nonhistone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 activates the innate system and mediates a wide range of physiological and pathological responses. HMGB1 exerts these actions through differential engagement of multiple surface receptors, including Toll-like receptor (TLR)2, TLR4, and receptor for advanced glycation end products (RAGE)...
September 2014: European Journal of Pediatrics
https://www.readbyqxmd.com/read/24667615/cerebrospinal-fluid-mitochondrial-dna-a-novel-damp-in-pediatric-traumatic-brain-injury
#8
Thomas D Walko, R Aaron Bola, John D Hong, Alicia K Au, Michael J Bell, Patrick M Kochanek, Robert S B Clark, Rajesh K Aneja
Danger-associated molecular patterns (DAMPs) are nuclear or cytoplasmic proteins that are released from the injured tissues and activate the innate immune system. Mitochondrial DNA (mtDNA) is a novel DAMP that is released into the extracellular milieu subsequent to cell death and injury. We hypothesized that cell death within the central nervous system in children with traumatic brain injury (TBI) would lead to the release of mtDNA into the cerebrospinal fluid (CSF) and has the potential to predict the outcome after trauma...
June 2014: Shock
https://www.readbyqxmd.com/read/24236762/high-mobility-group-box-1-hmgb-1-and-serum-soluble-receptor-for-advanced-glycation-end-products-srage-in-children-affected-by-vernal-keratoconjunctivitis
#9
Anna Maria Zicari, Alessandra Zicari, Marcella Nebbioso, Emanuela Mari, Camilla Celani, Valeria Lollobrigida, Azzurra Cesoni Marcelli, Francesca Occasi, Marzia Duse
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic disease affecting conjunctiva even though the immunopathogenetic mechanisms underlying this inflammation are unclear. The aim of our study is to investigate serum levels of HMGB1 and circulating sRAGE in children affected by VKC before and after treatment with cyclosporine A (CsA) eye drops and in a group of healthy children. METHODS: Twenty-four children affected by VKC aged between 5 and 12 yrs of life were enrolled at the Department of Pediatrics, Division of Allergy and Immunology, 'Sapienza' University of Rome...
February 2014: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/22540160/cerebrospinal-fluid-levels-of-high-mobility-group-box-1-and-cytochrome-c-predict-outcome-after-pediatric-traumatic-brain-injury
#10
Alicia K Au, Rajesh K Aneja, Michael J Bell, Hülya Bayir, Keri Feldman, P David Adelson, Ericka L Fink, Patrick M Kochanek, Robert S B Clark
High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochrome c may in part reflect the degree of necrosis and apoptosis present after traumatic brain injury (TBI), where both are felt to contribute to cell death and neurological morbidity. Ventricular cerebrospinal fluid (CSF) was obtained from children admitted to the intensive care unit (ICU) after TBI (n=37)...
July 20, 2012: Journal of Neurotrauma
https://www.readbyqxmd.com/read/21862344/increased-levels-of-cytokines-and-high-mobility-group-box-1-are-associated-with-the-development-of-severe-pneumonia-but-not-acute-encephalopathy-in-2009-h1n1-influenza-infected-children
#11
Yoshinori Ito, Yuka Torii, Rieko Ohta, Masaki Imai, Shinya Hara, Yoshihiko Kawano, Tadashi Matsubayashi, Ayano Inui, Tetsushi Yoshikawa, Naoko Nishimura, Takao Ozaki, Tsuneo Morishima, Hiroshi Kimura
BACKGROUND: The 2009 A(H1N1) influenza virus has caused a large outbreak, and resulted in major complications of severe pneumonia and acute encephalopathy in the pediatric population in Japan. METHODS: This study examined six patients with acute encephalopathy, 34 patients with severe pneumonia, five patients with both pneumonia and encephalopathy, and 46 patients without severe complications. The concentrations of 27 cytokines were examined in the cerebrospinal fluid of patients with encephalopathy, and the levels of these cytokines, Cytochrome c, high-mobility group box 1 (HMGB1) were measured in the serum of all patients...
November 2011: Cytokine
https://www.readbyqxmd.com/read/21788990/fecal-hmgb1-is-a-novel-marker-of-intestinal-mucosal-inflammation-in-pediatric-inflammatory-bowel-disease
#12
Roberta Vitali, Laura Stronati, Anna Negroni, Giovanni Di Nardo, Maria Pierdomenico, Emanuela del Giudice, Paolo Rossi, Salvatore Cucchiara
OBJECTIVES: High-mobility group box 1 (HMGB1) is a nuclear protein with functions in the regulation of transcription. In inflammatory conditions, HMGB1 is actively secreted from immune cells in the extracellular matrix, where it behaves as a proinflammatory cytokine. The aim of the present study was to investigate the role of HMGB1 in pediatric inflammatory bowel disease (IBD). METHODS: We analyzed the stools of 19 children with Crohn's disease (CD), 21 with ulcerative colitis (UC), and 13 controls...
November 2011: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/21389264/netting-neutrophils-are-major-inducers-of-type-i-ifn-production-in-pediatric-systemic-lupus-erythematosus
#13
Gina S Garcia-Romo, Simone Caielli, Barbara Vega, John Connolly, Florence Allantaz, Zhaohui Xu, Marilynn Punaro, Jeanine Baisch, Cristiana Guiducci, Robert L Coffman, Franck J Barrat, Jacques Banchereau, Virginia Pascual
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of immune complexes. Genomic approaches have shown that human SLE leukocytes homogeneously express type I interferon (IFN)-induced and neutrophil-related transcripts. Increased production and/or bioavailability of IFN-α and associated alterations in dendritic cell (DC) homeostasis have been linked to lupus pathogenesis. Although neutrophils have long been shown to be associated with lupus, their potential role in disease pathogenesis remains elusive...
March 9, 2011: Science Translational Medicine
https://www.readbyqxmd.com/read/21244468/serum-concentrations-of-complement-anaphylatoxins-and-proinflammatory-mediators-in-patients-with-2009-h1n1-influenza
#14
Rieko Ohta, Yuka Torii, Masaki Imai, Hiroshi Kimura, Noriko Okada, Yoshinori Ito
Anaphylatoxins (C5a, C4a, and C3a) are fragments of activated complement and are leading mediators of the inflammatory response for controlling viral infection. However, an excessive response may increase the severity of infectious diseases. Serum concentrations of proinflammatory mediators, including cytokines, high-mobility group box 1 and anaphylatoxins, were measured in pediatric 2009 H1N1 influenza patients in order to investigate the pathology of this new influenza. The concentrations of all three anaphylatoxins were significantly enhanced by 2009 H1N1 influenza infection...
March 2011: Microbiology and Immunology
https://www.readbyqxmd.com/read/18090368/a-pilot-study-to-detect-high-mobility-group-box-1-and-heat-shock-protein-72-in-cerebrospinal-fluid-of-pediatric-patients-with-meningitis
#15
COMPARATIVE STUDY
Daolin Tang, Rui Kang, Lizhi Cao, Guoyuan Zhang, Yan Yu, Weimin Xiao, Haichao Wang, Xianzhong Xiao
OBJECTIVE: To determine whether cerebrospinal fluid (CSF) levels of high mobility group box 1 (HMGB1) or heat shock protein 72 (Hsp72) are elevated in patients with meningitis. DESIGN: Prospective study of four cohorts of patients. SETTING: Intensive care unit and infectious disease clinic of pediatrics at the Xiangya Hospital. PATIENTS: A total of 104 children (13 with bacterial meningitis, 38 with aseptic meningitis, 7 with tuberculous meningitis, and 46 without meningitis)...
January 2008: Critical Care Medicine
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