Tairan Zhong, Haiming Wu, Jiehua Hu, Yun Liu, Yundan Zheng, Nan Li, Zhenghua Sun, Xing-Feng Yin, Qing-Yu He, Xuesong Sun
Single-nucleotide polymorphism (SNP) is one of the core mechanisms that respond to antibiotic resistance of Escherichia coli (E. coli), which is a major issue in environmental pollution. A specific type of SNPs, synonymous SNPs, have been generally considered as the "silent" SNPs since they do not change the encoded amino acid. However, the impact of synonymous SNPs on mRNA splicing, nucleo-cytoplasmic export, stability, and translation was gradually discovered in the last decades. Figuring out the mechanism of synonymous SNPs in regulating antibiotic resistance is critical to improve antimicrobial therapy strategies in clinics and biological treatment strategies of antibiotic-resistant E...
February 20, 2024: Journal of Hazardous Materials