keyword
https://read.qxmd.com/read/38458586/enhanced-degradation-of-enoxacin-using-ferrihydrite-catalyzed-heterogeneous-photo-fenton-process
#21
JOURNAL ARTICLE
Lin Tian, Liting Wang, Shikun Wei, Liwen Zhang, Deming Dong, Zhiyong Guo
The ferrihydrite-catalyzed heterogeneous photo-Fenton reaction shows great potential for environmental remediation of fluoroquinolone (FQs) antibiotics. The degradation of enoxacin, a model of FQ antibiotics, was studied by a batch experiment and theoretical calculation. The results revealed that the degradation efficiency of enoxacin reached 89.7% at pH 3. The hydroxyl radical (∙OH) had a significant impact on the degradation process, with a cumulative concentration of 43.9 μmol L-1 at pH 3...
March 6, 2024: Environmental Research
https://read.qxmd.com/read/38458537/changes-in-antimicrobial-resistance-of-escherichia-coli-isolated-from-community-associated-urinary-tract-infection-before-and-during-the-covid-19-pandemic-in-india
#22
JOURNAL ARTICLE
Shwetha Venugopal, Sneha Chunchanur, Rajashree Panigrahy, Vibhor Tak, Manish Yadav, Akanksha Chauhan, Himabindhu Ks, Jayapriya R, Swati Pundir, Satyendra Bhatt, Birasen Behera, Sumanth M, Ambica R, Susmita Chaudhuri, Sarita Mohapatra
PURPOSE: Impact of COVID-19 pandemic on antimicrobial resistance (AMR) is largely studied in healthcare settings, there is a need to understand the fluctuations in AMR during pandemic at the community level. Urinary tract infection (UTI) being one of the most common infections in the community, AMR profile of Community-acquired UTI (CA-UTI) is considered representative AMR at the community level. PATIENTS AND METHODS: The study was taken in cohort of patients with clinical diagnosis of CA-UTI...
March 6, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38452175/multidrug-resistant-and-carbapenemase-gene-carrying-acinetobacter-colistiniresistens-isolated-from-bloodstream-infection
#23
JOURNAL ARTICLE
Hae-Sun Chung, Chorong Hahm, Min-Kyung So, Miae Lee
In this study, we investigated the antimicrobial susceptibility and molecular characteristics of antimicrobial resistance of Acinetobacter colistiniresistens strains isolated from the bloodstream using whole-genome sequencing. Clinical isolates identified as Acinetobacter baumannii and showing colistin resistance at the time of detection were collected. Antimicrobial susceptibility was determined using the VITEK2 system (bioMérieux) and Sensititre system (Thermo Fisher Scientific). Species identification and antimicrobial resistance gene searches were performed through whole-genome sequencing...
March 7, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38450165/pan-genome-analysis-of-streptococcus-suis-serotype-2-highlights-genes-associated-with-virulence-and-antibiotic-resistance
#24
JOURNAL ARTICLE
You Zhou, Teng Tu, Xueping Yao, Yan Luo, Zexiao Yang, Meishen Ren, Ge Zhang, Yuanyuan Yu, Aiping Lu, Yin Wang
Streptococcus suis serotype 2 (SS2) is a Gram-positive bacterium. It is a common and significant pathogen in pigs and a common cause of zoonotic meningitis in humans. It can lead to sepsis, endocarditis, arthritis, and pneumonia. If not diagnosed and treated promptly, it has a high mortality rate. The pan-genome of SS2 is open, and with an increasing number of genes, the core genome and accessory genome may exhibit more pronounced differences. Due to the diversity of SS2, the genes related to its virulence and resistance are still unclear...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38448824/polycystic-intrahepatic-infection-caused-by-enterococcus-casseliflavus-a-case-report-and-literature-review
#25
JOURNAL ARTICLE
Senyin Xu, Bin Huang, Youjun Cao, Zhongyong Zhong, Jiazhen Yin
BACKGROUND: Enterococcus casseliflavus is a rare pathogenic bacterium that is characterized by vancomycin resistance and can lead to multiple infections in the human body. This report describes a rare case of polycystic intrahepatic infection with E. casseliflavus which necessitated antibiotic treatment and surgical intervention involving cystic drainage. CASE PRESENTATION: A 59-year-old woman, a long-term hemodialysis patient, was hospitalized due to a 5-day history of fever, abdominal pain, and diarrhea, which were possibly caused by the ingestion of contaminated food...
March 6, 2024: BMC Nephrology
https://read.qxmd.com/read/38448785/antimicrobial-prophylaxis-protocol-based-on-rectal-swab-culture-before-prostate-biopsy-to-prevent-infectious-complications-a-prospective-randomized-comparative-study
#26
JOURNAL ARTICLE
A Bouzouita, A Rehaiem, A Saadi, S Zaghbib, M Chakroun, H Ayed, A Ferjani, A Derouiche, I Boutiba-Ben Boubaker, M R Ben Slama
PURPOSE: To evaluate the benefit of targeted antibiotic prophylaxis (TAP) based on rectal swab culture in comparison with standard empiric antimicrobial prophylaxis in patients undergoing transrectal ultrasound-guided needle biopsy of the prostate (TRUS-BP), as well as to assess rate of fecal carriage of Fluoroquinolone-resistant Enterobacterales FQRE. PATIENTS AND METHODS: We prospectively analyzed data that randomized 157 patients within two groups: (G1) TAP according to rectal swab performed 10 days before PB; (G2): empirical antibiotic prophylaxis with ciprofloxacin...
March 7, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38447237/hydroxyl-containing-triazine-based-conjugated-microporous-polymers-for-solid-phase-extraction-of-fluoroquinolone-antibiotics-in-the-environment-and-food-samples
#27
JOURNAL ARTICLE
Lu-Shu Meng, Xiao-Li Wang, Xia Wang, Lei Ji, Lei-Lei Wang, Ya-Qi Cai, Ru-Song Zhao
Fluoroquinolones (FQs) are a category of broadly used antibiotics. Development of an effective and sensitive approach for determination of trace FQs in environmental and food samples is still challenging. Herein, the hydroxyl-containing triazine-based conjugated microporous polymers (CMPs-OH) was constructed and served as SPE absorbent for the efficient enrichment of FQs. Based on DFT simulations, the excellent enrichment capacity between CMPs-OH and FQs was contributed by hydrogen bonding and π-π interactions...
February 28, 2024: Food Chemistry
https://read.qxmd.com/read/38442815/age-and-sex-differences-in-pharmaceutical-contamination-in-a-keystone-scavenger
#28
JOURNAL ARTICLE
Guillermo Blanco, Martina Carrete, Isabel Navas, Antonio J García-Fernández
Pharmaceutical contaminants have a recognized negative impact on wildlife health. However, there are still many knowledge gaps on the factors influencing exposure and metabolic processing of compound mixtures as a function of season and individual characteristics such as age and sex. We evaluated age and sex differences in a set of seventeen compounds, including eleven antibiotics, five NSAIDs and caffeine, evaluated by HPLC-MS-TOF analysis in griffon vultures (Gyps fulvus) from central Spain. Pharmaceutical cocktails (up to 10 compounds simultaneously) were found in all individuals...
March 3, 2024: Environmental Research
https://read.qxmd.com/read/38438500/in-vitro-and-ex-vivo-activity-of-the-fluoroquinolone-dc-159a-against-mycobacteria
#29
JOURNAL ARTICLE
Belén R Imperiale, María B Mancino, Roberto D Moyano, Silvia de la Barrera, Nora S Morcillo
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistant tuberculosis (MDR-TB) cases. Besides, non-tuberculous mycobacteria (NTM) are highly resistant to several drugs and the emergence of fluoroquinolone (FQ) resistant M. tuberculosis (Mtb) is also a global concern making treatments difficult and with variable outcome. The aim of this study was to evaluate the activity of the FQ, DC-159a, against Mtb and NTM and to explore the cross-resistance with the currently used FQs...
March 4, 2024: Journal of Antibiotics
https://read.qxmd.com/read/38438028/ecotoxicity-of-the-fluoroquinolone-antibiotic-delafloxacin-to-the-water-flea-simocephalus-vetulus-and-its-offspring-under-the-influence-of-calcium-modulation
#30
JOURNAL ARTICLE
Tan-Duc Nguyen, Tomoaki Itayama, Quang Vinh Tran, Thanh-Son Dao, Muhammad Shahid Iqbal, Thanh Luu Pham
Delafloxacin (DFX), one of the latest additions to the fluoroquinolone antibiotics, is gaining heightened recognition in human therapy due to its potential antibacterial efficacy in a wide range of applications. Concerns have arisen regarding its presence in the environment and its potential interactions with multivalent metals, such as calcium (Ca). The present study investigated the trans- and multigenerational effects of environmentally projected concentrations of DFX (100-400 μg DFX L-1 ) on individual- and population-level responses of parental S...
March 2, 2024: Science of the Total Environment
https://read.qxmd.com/read/38432089/two-synonymous-single-nucleotide-polymorphisms-promoting-fluoroquinolone-resistance-of-escherichia-coli-in-the-environment
#31
JOURNAL ARTICLE
Tairan Zhong, Haiming Wu, Jiehua Hu, Yun Liu, Yundan Zheng, Nan Li, Zhenghua Sun, Xing-Feng Yin, Qing-Yu He, Xuesong Sun
Single-nucleotide polymorphism (SNP) is one of the core mechanisms that respond to antibiotic resistance of Escherichia coli (E. coli), which is a major issue in environmental pollution. A specific type of SNPs, synonymous SNPs, have been generally considered as the "silent" SNPs since they do not change the encoded amino acid. However, the impact of synonymous SNPs on mRNA splicing, nucleo-cytoplasmic export, stability, and translation was gradually discovered in the last decades. Figuring out the mechanism of synonymous SNPs in regulating antibiotic resistance is critical to improve antimicrobial therapy strategies in clinics and biological treatment strategies of antibiotic-resistant E...
February 20, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38431823/relation-of-streptococcus-pyogenes-tonsillitis-isolate-to-antimicrobial-agents-and-its-infection-treatment
#32
JOURNAL ARTICLE
Daryna B Pylypiv, Boris M Sharga, Olexandr A Rishko, Vitalii Leshak, Elena Karbovanets
We reported the case of tonsillitis treatment in a 17-years-old boy with use of chemical non-antibiotic preparations, plant derived products and antibiotic benzathine phenoxymethylpenicillin. The antimicrobial agents for treatment were selected on the basis of their activity against a disease agent, the group A β-hemolytic strain Streptococcus pyogenes BS1 isolated from a patient. The bacterium was susceptible in vitro to β-lactams, with largest zones conditioned by penicillin G and benzathine phenoxymethylpenicillin discs, to fluoroquinolones and to cephems, with exception of cefazolin...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38428833/antibiotic-prescribing-patterns-for-urinary-tract-infections-and-pneumonia-by-prescriber-type-and-specialty-in-nursing-home-care-2016-2018
#33
JOURNAL ARTICLE
Joe B B Silva, Melissa R Riester, Andrew R Zullo
OBJECTIVE: To identify whether differences in antibiotic prescribing practices by prescriber type and specialization in nursing home (NH) care exist for urinary tract infection (UTI) and pneumonia. DESIGN: Retrospective cohort. SETTING AND PARTICIPANTS: This national study included antibiotic dispensings to traditional Medicare beneficiaries aged ≥65 years with UTI or pneumonia infections residing long-term (≥100 days) in US NHs between 2016 and 2018...
February 27, 2024: Journal of the American Medical Directors Association
https://read.qxmd.com/read/38428041/how-should-we-activate-ferrate-vi-fe-iv-and-fe-v-tell-different-stories-about-fluoroquinolone-transformation-and-toxicity-changes
#34
JOURNAL ARTICLE
Zhongjuan Wang, Ye Du, Tong Liu, Jie Li, Chuan-Shu He, Yang Liu, ZhaoKun Xiong, Bo Lai
Many studies have investigated activation of ferrate (Fe(VI)) to produce reactive high-valent iron intermediates to enhance the oxidation of micropollutants. However, the differences in the risk of pollutant transformation caused by Fe(IV) and Fe(V) have not been taken seriously. In this study, Fe(VI)-alone, Fe3+ /Fe(VI), and NaHCO3 /Fe(VI) processes were used to oxidize fluoroquinolone antibiotics to explore the different effects of Fe(IV) and Fe(V) on product accumulation and toxicity changes. The contribution of Fe(IV) to levofloxacin degradation was 99...
March 1, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38426065/first-report-of-coexistence-of-blakpc-2-and-blandm-1-in-carbapenem-resistant-clinical-isolates-of-klebsiella-aerogenes-in-brazil
#35
JOURNAL ARTICLE
Saulo Henrique Rodrigues, Gustavo Dantas Nunes, Gabriela Guerrera Soares, Roumayne Lopes Ferreira, Marcelo Silva Folhas Damas, Pedro Mendes Laprega, Rebecca Elizabeth Shilling, Leslie Camelo Campos, Andrea Soares da Costa, Iran Malavazi, Anderson Ferreira da Cunha, Maria-Cristina da Silva Pranchevicius
Klebsiella aerogenes is an important opportunistic pathogen with the potential to develop resistance against last-line antibiotics, such as carbapenems, limiting the treatment options. Here, we investigated the antibiotic resistance profiles of 10 K. aerogenes strains isolated from patient samples in the intensive-care unit of a Brazilian tertiary hospital using conventional PCR and a comprehensive genomic characterization of a specific K. aerogenes strain (CRK317) carrying both the bla KPC-2 and bla NDM-1 genes simultaneously...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38423242/fluoroquinolones-upregulate-insulin-like-growth-factor-binding-protein-3-inhibit-cell-growth-and-insulin-like-growth-factor-signaling
#36
JOURNAL ARTICLE
Chih-Ling Chung, Chun-Lin Chen
Fluoroquinolones (FQs), commonly known for their antibiotic properties, exhibit additional pharmacological potential with anti-proliferative effects on various malignant cell types and immunomodulatory responses. Despite these observed effects, the precise mechanisms of action remain elusive. This study elucidates the biological impact of FQs on insulin-like growth factor-binding protein 3 (IGFBP-3) productions in a p53-dependent manner. Cultured cells and mouse models treated with FQs demonstrated increased IGFBP-3 mRNA expression and protein secretion...
February 27, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38421944/intoxication-of-antibiotic-persisters-by-host-rns-inactivates-their-efflux-machinery-during-infection
#37
JOURNAL ARTICLE
Séverin Ronneau, Charlotte Michaux, Rachel T Giorgio, Sophie Helaine
The host environment is of critical importance for antibiotic efficacy. By impacting bacterial machineries, stresses encountered by pathogens during infection promote the formation of phenotypic variants that are transiently insensitive to the action of antibiotics. It is assumed that these recalcitrant bacteria-termed persisters-contribute to antibiotic treatment failure and relapsing infections. Recently, we demonstrated that host reactive nitrogen species (RNS) transiently protect persisters against the action of β-lactam antibiotics by delaying their regrowth within host cells...
February 2024: PLoS Pathogens
https://read.qxmd.com/read/38421718/prediction-of-antibiotic-resistance-in-patients-with-a-urinary-tract-infection-algorithm-development-and-validation
#38
JOURNAL ARTICLE
Nevruz İlhanlı, Se Yoon Park, Jaewoong Kim, Jee An Ryu, Ahmet Yardımcı, Dukyong Yoon
BACKGROUND: The early prediction of antibiotic resistance in patients with a urinary tract infection (UTI) is important to guide appropriate antibiotic therapy selection. OBJECTIVE: In this study, we aimed to predict antibiotic resistance in patients with a UTI. Additionally, we aimed to interpret the machine learning models we developed. METHODS: The electronic medical records of patients who were admitted to Yongin Severance Hospital, South Korea were used...
February 29, 2024: JMIR Medical Informatics
https://read.qxmd.com/read/38420252/multilevel-pre-extensively-drug-resistant-tubercular-spondylodiscitis-underdiagnosed-or-overlooked-a-case-report
#39
Tanmay Avhad, S Subith, Vanksha Shrivastava, Syed Zafar, Arif Chaudhary
INTRODUCTION: Pre-extensively drug-resistant tuberculosis (TB) is characterized by resistance to either a fluoroquinolone (FQ) or a second-line injectable but not both. The urgent need for prompt diagnosis and targeted treatment is emphasized. This report aims to spotlight a case of spinal TB with insufficient assessment, resulting in delayed definitive treatment and an oversight contributing to heightened morbidity. CASE REPORT: An 18-year-old female who was initially diagnosed to have multidrug-resistant TB leading to a 2-year treatment which eventually resulted in multifocal involvement of the spine revealing TB relapse with FQ resistance, categorized as pre-extensively drug-resistant TB...
February 2024: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/38417863/dissemination-of-urinary-escherichia-coli-phylogroup-b2-in-provincial-and-community-hospitals-in-uthai-thani-central-thailand
#40
JOURNAL ARTICLE
Chanihcha Anudit, Pornthip Saraisuwan, Chantana Kimterng, Chanakan Puangmanee, Nicharee Bamphensin, Anusak Kerdsin
Escherichia coli is a Gram-negative bacterium that prominently causes a variety of clinical infections in humans, such as diarrhea, sepsis, and urinary tract infection. This bacterium is a common multidrug-resistant threat in community and hospital settings worldwide. This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin...
February 29, 2024: Japanese Journal of Infectious Diseases
keyword
keyword
98332
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.