Petter Bjornstad, Gabriel Richard, Ye Ji Choi, Kristen L Nowak, Cortney Steele, Michel B Chonchol, Kristen J Nadeau, Timothy Vigers, Laura Pyle, Kalie Tommerdahl, Daniel H van Raalte, Allison Hilkin, Lynette Driscoll, Carissa Birznieks, Katharina Hopp, Wei Wang, Charles Edelstein, Robert G Nelson, Adriana V Gregory, Timothy L Kline, Denis Blondin, Berenice Gitomer
RATIONALE & OBJECTIVE: In this pilot study, we hypothesized that autosomal dominant polycystic kidney disease (ADPKD) is characterized by impaired kidney oxidative metabolism that associates with kidney size and cyst burden. STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: Twenty adults with ADPKD (31±6 years of age, 65% women, BMI: 26.8 [22.7, 30.4] kg/m2 , eGFR (2021 CKD-EPI Creatinine): 103±18 ml/min/1.73m2 , height-adjusted total kidney volume [HtTKV]: 731±370 ml/m, Mayo Classifications: 1B [5%], 1C [42%], 1D [21%], 1E [32%]) and 11 controls in normal weight category (NWC; 25±3 years of age, 45% women, BMI: 22...
April 13, 2024: American Journal of Kidney Diseases