keyword
https://read.qxmd.com/read/38543714/hbcab-positivity-as-a-risk-factor-for-missing-hiv-rna-undetectability-after-the-3tc-dtg-switch
#1
JOURNAL ARTICLE
Vincenzo Malagnino, Tiziana Mulas, Elisabetta Teti, Monica Basso, Mario Giobbia, Nicholas Geremia, Giuliana Battagin, Yasmine Abi Aad, Jean-Paul Vincensini, Marco Iannetta, Saverio Giuseppe Parisi, Loredana Sarmati, Karine Lacombe
Hepatitis B Core antibody (HBcAb) positivity is the surrogate marker of hepatitis B occult infection. This condition is not a contraindication for switching to two-drug (2DR) antiretroviral therapy; however, the removal of tenofovir may contribute to poor control of HBV replication. A multicentre retrospective cohort study investigated the impact of HBcAb positivity on HIV control in patients switching to a 2DR with Lamivudine and Dolutegravir (3TC-DTG). In this study, a comparison analysis was conducted between HBcAb-positive and -negative PLWH regarding HIV-RNA suppression, considering: (1): Target Not Detected (TND) < 20 cp/mL; (2) Target Detected (TD) < 20 cp/mL; and (3) Detectable > 20 cp/mL and <50 cp/mL and >50 copies/mL...
February 23, 2024: Viruses
https://read.qxmd.com/read/38540179/two-waves-of-specific-b-cell-memory-immunoreconstruction-observed-in-anti-hhv1-3-igg-kinetics-after-hematopoietic-stem-cell-transplantation
#2
JOURNAL ARTICLE
Przemyslaw Zdziarski, Andrzej Gamian
BACKGROUND: Humoral memory and specific antibody levels depend on the kind of antigen and individual immunofactors. The presence of IgM antibodies or a fourfold rise in specific IgG levels are generally accepted as diagnostic factors in the serology of acute viral infections. This basic model is not adequate for the herpes virome, especially after hematopoietic stem cell transplantation (HSCT), due to continuous, usually multifocal antigenic stimulation, various donor serostatuses, immunosuppression, and individual immunoreconstitution...
March 3, 2024: Biomedicines
https://read.qxmd.com/read/38531921/estimating-the-size-of-populations-at-risk-for-malaria-a-case-study-in-cattle-herders-and-agricultural-workers-in-northern-namibia
#3
JOURNAL ARTICLE
Francois Rerolle, Jerry O Jacobson, Cara Smith Gueye, Adam Bennett, Sidney Carrillo, Henry Ntuku, Jennifer L Smith
Cattle herders and agricultural workers have been identified has key high-risk populations for malaria in northern Namibia. Population size estimates for these groups are lacking but are important for planning, monitoring and evaluating the effectiveness of targeted strategies towards malaria elimination in the region. In this analysis, we extend population size estimation methods routinely used in HIV research, specifically social mapping and multiple source capture-recapture, to the context of malaria to estimate how many cattle herders and agricultural workers lived in two regions of northern Namibia over the course of the 2019-2020 malaria season...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530258/common-oral-conditions-a-review
#4
JOURNAL ARTICLE
Eric T Stoopler, Alessandro Villa, Mohammed Bindakhil, David L Ojeda Díaz, Thomas P Sollecito
IMPORTANCE: Dry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity. OBSERVATIONS: In a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis, dental caries, dysgeusia, masticatory/speech impairment, and oropharyngeal dysphagia...
March 26, 2024: JAMA
https://read.qxmd.com/read/38524687/determinants-of-metabolic-syndrome-among-patients-receiving-anti-retro-viral-treatment-in-a-tertiary-hospital-central-ethiopia-unmatched-case-control-study
#5
JOURNAL ARTICLE
Godana Jarso, Haji Aman, Abebe Megerso
PURPOSE: Scaling up antiretroviral treatment (ART) reduces morbidity and mortality among people living with HIV/AIDS (PLHA). This success is challenged by the constellation of interrelated metabolic disorders such as metabolic syndrome (MetS). Given the changing ART regimens and schedules, increasing patient age and methodological limitations, existing evidence regarding the determinants of MetS remains inconclusive. Therefore, in the current study, we aimed to identify the determinants of MetS in patients receiving ART at a tertiary hospital in central Ethiopia...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38523735/risk-factors-for-development-of-cirrhosis-in-chronic-viral-hepatitis-b-patients-who-had-persistent-viral-suppression-with-antiviral-therapy
#6
JOURNAL ARTICLE
Soe T Maung, Pakanat Decharatanachart, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
BACKGROUND AND AIMS: Chronic viral hepatitis B (CHB)-infected patients occasionally develop cirrhosis despite having persistent viral suppression with antiviral therapy. We aimed to identify risk factors for developing cirrhosis in hepatitis B virus (HBV)-suppressed patients. METHODS: We conducted a case-control study involving 120 noncirrhotic CHB-infected patients achieving viral suppression with antiviral treatment, with 40 cases developing cirrhosis and 80 age-, sex-, and Fibrosis-4 (FIB-4)-matched controls...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38522155/leishmania-and-hiv-co-infection-first-naturally-leishmania-strain-presenting-decreased-susceptibility-to-miltefosine-recovered-from-a-patient-in-portugal
#7
JOURNAL ARTICLE
Ana Isabel Pinto, Cátia Caldas, Nuno Santarém, Sara Luelmo, Inês Costa, Carlos Martins, Ricardo Monteiro, Sílvia Conde, Raquel Tavares, Anabela Cordeiro da Silva
BACKGROUND: In Europe, up to 70% of visceral leishmaniasis (VL) cases occurring in adults living with HIV. People living with HIV with VL co-infection often display persistent parasitemia, requiring chronic intermittent anti-Leishmania therapies. Consequently, frequent VL relapses and higher mortality rates are common in these individuals. As such, it is of paramount importance to understand the reasons for parasite persistence to improve infection management. METHODS: To outline possible causes for treatment failure in the context of HIV-VL, we followed a person living with HIV-VL co-infection for nine years in a 12-month period...
March 13, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38520030/peers-plus-mobile-app-for-treatment-in-hiv-path-protocol-for-a-randomized-controlled-trial-to-test-a-community-based-integrated-peer-support-and-mhealth-intervention-to-improve-viral-suppression-among-hispanic-and-black-people-living-with-hiv
#8
JOURNAL ARTICLE
Eileen V Pitpitan, Keith J Horvath, Jeannette Aldous, Jamila K Stockman, Thomas L Patterson, Megan Liang, Constantino Barrozo, Veronica Moore, Katherine Penninga, Laramie R Smith
BACKGROUND: Significant disparities continue to exist in the HIV care continuum, whereby Hispanic and Black people living with HIV (PLWH) are less likely to achieve viral suppression compared to their White counterparts. Studies have shown that intervention approaches that involve peer navigation may play an important role in supporting patients to stay engaged in HIV care. However, implementation may be challenging in real-world settings where there are limited resources to support peer navigators...
March 22, 2024: Trials
https://read.qxmd.com/read/38517865/aetiological-agents-of-pneumonia-among-hiv-and-non-hiv-infected-children-in-ghana-a-case-control-study
#9
JOURNAL ARTICLE
Michael Owusu, Eric Adu, Lotenna Elsie Kalu, Eugene Martey, Godfred Acheampong, Anthony Enimil, John Adabie Appiah, Augustina Badu-Peprah, Justice Sylverken, Augustina Angelina Sylverken, Samuel Blay Nguah, Emilie Westeel, Stephane Pouzol, Christian Drosten, Yaw Adu-Sarkodie
Pneumonia is the leading cause of death in children, however, the microbial aetiology of pneumonia is not well elucidated in low- and middle-income countries. Our study was aimed at determining the microbial aetiologies of childhood pneumonia and associated risk factors in HIV and non-HIV infected children. We conducted a case-control study that enrolled children with pneumonia as cases and non-pneumonia as controls from July 2017 to May 2020. Induced sputum and blood samples were investigated for microbial organisms using standard microbiological techniques...
2024: PloS One
https://read.qxmd.com/read/38511668/community-views-on-active-case-finding-for-tuberculosis-in-low-and-middle-income-countries-a-qualitative-evidence-synthesis
#10
REVIEW
Melissa Taylor, Nancy Medley, Susanna S van Wyk, Sandy Oliver
BACKGROUND: Active case finding (ACF) refers to the systematic identification of people with tuberculosis in communities and amongst populations who do not present to health facilities, through approaches such as door-to-door screening or contact tracing. ACF may improve access to tuberculosis diagnosis and treatment for the poor and for people remote from diagnostic and treatment facilities. As a result, ACF may also reduce onward transmission. However, there is a need to understand how these programmes are experienced by communities in order to design appropriate services...
March 21, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38496497/circulating-cd4-t-cells-in-people-with-hiv-and-history-of-pulmonary-tuberculosis-have-more-intact-hiv-dna
#11
Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Conce Alberto, Daniel W Fitzgerald, Jean W Pape, R Brad Jones, Kathryn Dupnik
BACKGROUND: The primary barrier to curing HIV infection is the pool of intact HIV proviruses integrated into host cell DNA throughout the bodies of people living with HIV (PLHIV), called the HIV reservoir. Reservoir size is impacted by the duration of HIV infection, delay in starting antiretroviral therapy (ART), and breakthrough viremia during ART. The leading infectious cause of death worldwide for PLHIV is TB, but we don't know how TB impacts the HIV reservoir. METHODS: We designed a case-control study to compare HIV provirus-containing CD4 in PLHIV with vs...
March 7, 2024: medRxiv
https://read.qxmd.com/read/38494484/factors-influencing-rapid-antiretroviral-therapy-initiation-in-jiulongpo-chongqing-china-a-retrospective-cohort-from-2018-to-2022
#12
JOURNAL ARTICLE
Cheng Chen, Hao Chen, Lingli Wu, Qin Gong, Jingchun He
BACKGROUND: Antiretroviral Therapy (ART) is pivotal in extending the lives of people living with HIV (PLWH) and minimizing transmission. Rapid ART initiation, defined as commencing ART within seven days of HIV diagnosis, is recommended for all PLWH. METHOD: A retrospective cohort study was conducted using data from the China Information System for Disease Control and Prevention. This study included PLWH diagnosed between January 2018 and December 2021 and treated by December 2022...
March 17, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38493080/effectiveness-of-human-immunodeficiency-virus-prevention-strategies-by-mapping-the-geographic-dispersion-pattern-of-human-immunodeficiency-virus-prevalence-in-nanning-china
#13
JOURNAL ARTICLE
Ping Cen, Guo Xu, Jianxun Wu, Jiao Qin, Jinfeng He, Xiaofang Deng, Xi Yang, Peng Lu, Mengni Nong, Junjun Jiang, Li Ye, Hongyang Tang, Bingyu Liang, Hao Liang
BACKGROUND: The Guangxi government initiated two rounds of the Guangxi AIDS Conquering Project (GACP) in 2010 (Phase I) and 2015 (Phase II) to control human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemics. However, the effectiveness of GACP in HIV prevention and treatment has rarely been reported. This study aimed to assess the effectiveness of the GACP implemented in Guangxi, China and provide data for strategy and praxis improvements to achieve Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95 targets...
March 16, 2024: BMC Public Health
https://read.qxmd.com/read/38489489/risk-of-stroke-among-hiv-patients-a-systematic-review-and-meta-analysis-of-global-studies-and-associated-comorbidities
#14
JOURNAL ARTICLE
Mostafa Hossam El Din Moawad, Mahmoud Mohamed Mohamed Shalaby, Esraa Hamouda, Amany Mahfouz, Adel Mouffokes, Heba Hamouda, Abdallah Abbas, Hussien Ahmed H Abdelgawad
BACKGROUND: Despite advancements in the management of HIV infection, the factors contributing to stroke development among HIV-positive individuals remain unclear. This systematic review and meta-analysis aim to identify and evaluate the relative risk factors associated with stroke susceptibility in the HIV population. METHODS: A comprehensive search was conducted in PubMed, Scopus, and Web of Science databases to identify studies investigating the risk of stroke development in HIV patients and assessing the role of different risk factors, including hypertension, diabetes, dyslipidemia, smoking, sex, and race...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/38481376/incident-hiv-associated-wasting-low-weight-is-associated-with-nearly-doubled-mortality-risk-in-the-modern-art-era
#15
JOURNAL ARTICLE
Michael B Wohlfeiler, Rachel Palmieri Weber, Laurence Brunet, Javeed Siddiqui, Michael Harbour, Amy L Phillips, Brooke Hayward, Jennifer S Fusco, Ricky Hsu, Gregory P Fusco
HIV-associated wasting (HIVAW) is an under-appreciated AIDS-defining illness, despite highly effective antiretroviral therapy (ART). We (a) assessed the association between incident HIVAW/low weight and all-cause mortality and (b) described virologic outcomes after people with HIV (PWH) experienced HIVAW/low weight while on ART. In the Observational Pharmaco-Epidemiology Research & Analysis (OPERA® ) cohort, PWH without prior HIVAW/low weight who were active in care in 2016-2020 were followed through death, loss to follow-up, or study end (31OCT2021)...
March 14, 2024: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/38477724/trends-in-vasectomy-and-sexually-transmitted-diseases-in-chile-findings-from-robust-national-databases
#16
JOURNAL ARTICLE
Daniela Toledo, Cinthya Urquidi, Alejandro Sepúlveda-Peñaloza, Rodrigo Leyton
A controversy about the increase or decline of vasectomy is emerging; however, the evidence is still scarce in Latin America. This ecological study analyzed the vasectomy and sexual transmitted diseases (STD) trends over a period of 10 years in Chile and determined if there is any relationship between them. We conducted a mixed ecological study using secondary and representative data on the number of vasectomies and STD cases from 2008 to 2017. Vasectomy rates were calculated for age-specific groups of men aged 20-59 years, and specific STD (HIV, chlamydia, gonorrhea, trichomoniasis, and syphilis) for the same period...
2024: Cadernos de Saúde Pública
https://read.qxmd.com/read/38461830/performance-of-a-stool-based-quantitative-pcr-assay-for-the-diagnosis-of-tuberculosis-in-adolescents-and-adults-a-multinational-prospective-diagnostic-accuracy-study
#17
JOURNAL ARTICLE
Alexander Kay, Anca Vasiliu, Lucia Carratala-Castro, Bariki Mtafya, Jose Euberto Mendez Reyes, Nontobeko Maphalala, Shilzia Munguambe, Durbbin Mulengwa, Tara Ness, Belen Saavedra, Jason Bacha, Gugu Maphalala, Rojelio Mejia, Godwin Mtetwa, Sozinho Acacio, Patricia Manjate, Edson Mambuque, Nosisa Shiba, Nokwanda Kota, Mangaliso Ziyane, Nyanda Elias Ntinginya, Christoph Lange, H Lester Kirchner, Andrew R DiNardo, Alberto L Garcia-Basteiro, Anna Maria Mandalakas
BACKGROUND: Despite increasing availability of rapid molecular tests for the diagnosis of tuberculosis in high-burden settings, many people with tuberculosis are undiagnosed. Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with high tuberculosis burdens. METHODS: We undertook a prospective diagnostic accuracy study in Eswatini, Mozambique, and Tanzania from Sept 21, 2020, to Feb 2, 2023, to compare the diagnostic accuracy for tuberculosis of a novel stool qPCR test with the current diagnostic standard for Mycobacterium tuberculosis DNA detection from sputum and stool, Xpert-MTB/RIF Ultra (Xpert Ultra)...
March 7, 2024: The Lancet. Microbe
https://read.qxmd.com/read/38455701/hhv8-positive-multicentric-castleman-s-disease-and-thrombotic-thrombocytopenic-purpura-among-hiv-positive-patients
#18
JOURNAL ARTICLE
Roxane Pasquer, Yannick Dieudonné, Pauline Decours, Olivier Hinschberger, Alina Nicolae, Martin Martinot
UNLABELLED: Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38443751/correlates-of-early-breastfeeding-cessation-and-breastmilk-expression-in-uganda-a-case-control-study
#19
JOURNAL ARTICLE
Yu Du, Carolyn Onyango-Makumbi, Bhavneet Walia, Maxie Owor, Phillipa Musoke, Arthur H Owora
OBJECTIVE: To identify the correlates of early breastfeeding (BF) cessation and breastmilk expression (BE) among mothers 12 months after childbirth. METHODS: We used a case-control study design to compare characteristics between mothers who stopped BF and expressed breastmilk 12 months after childbirth in Uganda. BF practices were determined in 12-month follow-up interviews using an adapted World Health Organization infant feeding questionnaire. Univariate and bivariate logistic regression models identified correlates of early BF cessation and BE as distinct but related outcomes...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38438963/causal-effects-of-gut-microbiome-on-hiv-infection-a-two-sample-mendelian-randomization-analysis
#20
JOURNAL ARTICLE
Kangjie Li, Cong Zhang, Jielian Deng, Haijiao Zeng, Yuan Zhang, Guichuan Lai, Xiaoni Zhong, Biao Xie
BACKGROUND: The causal association between gut microbiome and HIV infection remains to be elucidated. We conducted a two-sample mendelian randomization analysis to estimate the causality between gut microbiome and HIV infection. METHODS: Publicly released genome-wide association studies summary data were collected to perform the mendelian analysis. The GWAS summary data of gut microbiome was retrieved from the MiBioGen consortium, which contains 18 340 samples from 24 cohorts...
March 4, 2024: BMC Infectious Diseases
keyword
keyword
98327
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.