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HIV case control study

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https://www.readbyqxmd.com/read/29682306/anti-m%C3%A3-llerian-hormone-levels-are-reduced-in-women-living-with-human-immunodeficiency-virus-compared-to-control-women-a-case-control-study-from-copenhagen-denmark
#1
EDITORIAL
Maria Wessman, Anne-Sofie Korsholm, Janne Gasseholm Bentzen, Anders Nyboe Andersen, Magnus Glindvad Ahlström, Terese Lea Katzenstein, Nina Weis
Objectives: Anti-müllerian hormone (AMH) is a marker of ovarian reserve. The purpose of this study was to compare AMH in women living with HIV with an age-matched control group of HIV-uninfected women, and to identify possible variables associated with decreasing AMH levels in women living with HIV. Methods: AMH was measured in frozen EDTA samples from 84 white women living with HIV, aged 20 -40 years, with fully suppressed HIV RNA viral loads for at least 6 months and no hepatitis B or C virus co-infection...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29677205/anemia-in-tuberculosis-cases-and-household-controls-from-tanzania-contribution-of-disease-coinfections-and-the-role-of-hepcidin
#2
Jerry Hella, Colin I Cercamondi, Francis Mhimbira, Mohamed Sasamalo, Nicole Stoffel, Marcel Zwahlen, Thomas Bodmer, Sebastien Gagneux, Klaus Reither, Michael B Zimmermann, Lorenz Risch, Lukas Fenner
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat outcomes. We studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among TB patients and household contacts. METHODS: We analyzed serum samples from 102 TB cases and 98 controls without TB, matched by age/sex, for hepcidin, iron, and inflammation parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29676453/risk-factors-for-burkitt-lymphoma-a-nested-case-control-study-in-the-uk-clinical-practice-research-datalink
#3
Parisa Karimi, Brenda M Birmann, Lesley A Anderson, Charlene M McShane, Shahinaz M Gadalla, Joshua N Sampson, Sam M Mbulaiteye
Burkitt lymphoma (BL) occurs as three subtypes: endemic BL, immunosuppression-related BL and sporadic BL. Descriptive studies of BL age-specific incidence patterns have suggested multimodal peaks near 10, 40 and 70 years of age, but the risk factors for BL at different ages are unknown. We investigated risk factors for BL in the United Kingdom among 156 BL cases and 608 matched BL-free controls identified in the Clinical Practice Research Datalink (CPRD) between 1992 and 2016. Associations with pre-diagnostic body mass index, cigarette smoking, alcohol consumption, hepatitis, Epstein-Barr virus (EBV), human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), malaria, allergic and autoimmune conditions, and prednisone use were evaluated...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#4
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29668812/reporting-of-hiv-infected-pregnant-women-estimates-from-a-brazilian-study
#5
Rosa Maria Soares Madeira Domingues, Valéria Saraceni, Maria do Carmo Leal
OBJECTIVE: To estimate the coverage of the reporting of cases of HIV-infected pregnant women, to estimate the increase in the coverage of the reporting with the routine search of data in other Brazilian health information systems, and to identify missed opportunities for identification of HIV-infected pregnant women in Brazilian maternity hospitals. METHODS: This is a descriptive study on the linkage of Brazilian databases with primary data from the "Nascer no Brasil" study and secondary database collection from national health information systems...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29666966/point-of-care-lung-ultrasound-for-diagnosis-of-pneumocystis-jirovecii-pneumonia-notes-from-the-field
#6
Maria Teresa Giordani, Francesca Tamarozzi, Daniel Kaminstein, Enrico Brunetti, Tom Heller
BACKGROUND: Thoracic ultrasound is helpful to evaluate lung pathology in patients with acute dyspnea. Several studies have demonstrated the efficacy of point-of-care ultrasound in patients with extrapulmonary TB and HIV co-infection. This retrospective, open-label case-control study explores the role of lung ultrasound in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV-positive patients. In particular, it highlights the potential role of specific sonographic features that may be unique to this population...
April 17, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29666343/interleukin-gene-polymorphisms-and-susceptibility-to-hiv-1-infection-a-meta-analysis
#7
Chrissa G Tsiara, Georgios K Nikolopoulos, Niki L Dimou, Katerina G Pantavou, Pantelis G Bagos, Benedicta Mensah, Michael Talias, Georgia G Braliou, Dimitra Paraskeva, Stefanos Bonovas, Angelos Hatzakis
Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case-control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29664037/provider-initiated-hiv-testing-counselling-in-incident-tuberculosis-cases-under-national-tb-programme-conditions-at-a-tertiary-care-teaching-hospital-in-tirupati-south-india
#8
Alladi Mohan, J Harikrishna, D Prabath Kumar, N Dinesh Kumar, Prerna S Sharma, B Siddhartha Kumar, K V S Sarma
Background & objectives: : As sparse published data are available regarding burden of human immunodeficiency virus (HIV) infection in incident tuberculosis (TB) cases at tertiary care teaching hospitals under National TB Programme conditions from India, the present study was designed to assess the proportion of referred registered TB patients who had actually undergone HIV testing and HIV-seropositivity in these. Methods: : This was a study of provider-initiated HIV testing and counselling in patients registered for the treatment under Revised National TB Control Programme (RNTCP) of Government of India at a tertiary care teaching hospital in Tirupati, south India, during 2012-2013...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29663358/a-case-control-study-of-hiv-infection-and-cancer-in-the-era-of-antiretroviral-therapy-in-rwanda
#9
Tharcisse Mpunga, Ariana Znaor, F Regis Uwizeye, Aline Uwase, Cyprien Munyanshongore, Silvia Franceschi, Gary M Clifford
The aim of our study was to assess the association between HIV infection and cancer risk in Rwanda approximately a decade after the introduction of antiretroviral therapy (cART). All persons seeking cancer care at Butaro Cancer Center of Excellence (BCCOE) in Rwanda from 2012 to 2016 were routinely screened for HIV, prior to being confirmed with or without cancer (cases and controls, respectively). Cases were coded according to ICD-O-3 and converted to ICD10. Associations between individual cancer types and HIV were estimated using adjusted unconditional logistic regression...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29661246/risk-factors-and-outcomes-for-the-q151m-and-t69-insertion-hiv-1-resistance-mutations-in-historic-uk-data
#10
Oliver T Stirrup, David T Dunn, Anna Tostevin, Caroline A Sabin, Anton Pozniak, David Asboe, Alison Cox, Chloe Orkin, Fabiola Martin, Patricia Cane
BACKGROUND: The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug resistance remains a substantial concern in many low and middle-income countries. The Q151M and T69 insertion (T69i) resistance mutations in the viral reverse transcriptase gene can reduce susceptibility to all nucleoside/tide analogue reverse transcriptase inhibitors, motivating the present study to investigate the risk factors and outcomes associated with these mutations...
April 16, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29659759/community-acquired-legionella-pneumonia-in-hiv-infected-adult-patients-a-matched-case-control-study
#11
Catia Cillóniz, Lucia Miguel-Escuder, María Luisa Pedro-Bonet, Vicenç Falcó, Yessica Lopez, Carolina García-Vidal, Albert Gabarrús, Asunción Moreno, Antoni Torres, José M Miró
We investigated whether the clinical presentations and outcomes (length of hospital stay [LOS], intensive care unit[ICU] admission, 30-day mortality) of Legionella pneumonia in HIV-infected patients were comparable to those without HIV infection.Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
April 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29658302/molecular-epidemiology-of-hiv-1-virus-in-puerto-rico-novel-cases-of-hiv-1-subtype-c-d-and-crf-24bg
#12
Pablo Lopez, Omayra De Jesus, Yasuhiro Yamamura, Nayra Rodriguez, Andrea Arias, Raphael Sanchez, Yadira Rodriguez, Vivian Tamayo-Agrait, Wilfredo Cuevas, Vanessa Rivera-Amill
Human immunodeficiency virus-1 (HIV-1) subtype B virus is the most prevalent subtype in Puerto Rico (PR), accounting for about 90% of infection in the island. Recently, other subtypes and circulating recombinant forms (CRF) including F (12_BF), A (01_BF), and CRF-39 BF-like have been identified. The purpose of this study is to assess the distribution of drug resistance mutations and subtypes in PR. A total of 846 nucleotide sequences from the period comprising 2013 through 2017 were obtained from our "HIV Genotyping" test file...
April 15, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29627814/a-systematic-review-of-interventions-by-healthcare-professionals-to-improve-management-of-non-communicable-diseases-and-communicable-diseases-requiring-long-term-care-in-adults-who-are-homeless
#13
Peter Hanlon, Lynsey Yeoman, Lauren Gibson, Regina Esiovwa, Andrea E Williamson, Frances S Mair, Richard Lowrie
OBJECTIVE: Identify, describe and appraise trials of interventions delivered by healthcare professionals to manage non-communicable diseases (NCDs) and communicable diseases that require long-term care or treatment (LT-CDs), excluding mental health and substance use disorders, in homeless adults. DESIGN: Systematic review of randomised controlled trials (RCTs), non-RCTs and controlled before-after studies. Interventions characterised using Effective Practice and Organisation of Care (EPOC) taxonomy...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29624071/four-gene-pan-african-blood-signature-predicts-progression-to-tuberculosis
#14
Sara Suliman, Ethan Thompson, Jayne Sutherland, January Weiner Rd, Martin O C Ota, Smitha Shankar, Adam Penn-Nicholson, Bonnie Thiel, Mzwandile Erasmus, Jeroen Maertzdorf, Fergal J Duffy, Philip C Hill, E Jane Hughes, Kim Stanley, Katrina Downing, Michelle L Fisher, Joe Valvo, Shreemanta K Parida, Gian van der Spuy, Gerard Tromp, Ifedayo M O Adetifa, Simon Donkor, Rawleigh Howe, Harriet Mayanja-Kizza, W Henry Boom, Hazel Dockrell, Tom H M Ottenhoff, Mark Hatherill, Alan Aderem, Willem A Hanekom, Thomas J Scriba, Stefan He Kaufmann, Daniel E Zak, Gerhard Walzl
RATIONALE: Contacts of tuberculosis (TB) patients constitute an important target population for preventative measures as they are at high risk of infection with Mycobacterium tuberculosis and progression to disease. OBJECTIVES: We investigated biosignatures with predictive ability for incident tuberculosis. METHODS: In a case-control study nested within the Grand Challenges 6-74 longitudinal HIV-negative African cohort of exposed household contacts, we employed RNA sequencing, polymerase chain reaction (PCR) and the Pair Ratio algorithm in a training/test set approach...
April 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29621966/the-epidemiology-of-urinary-tract-infections-in-hiv-positive-patients-at-a-tertiary-care-university-hospital-in-central-europe-2011-2016
#15
Romana Klasinc, Armin Rieger, Elisabeth Presterl, Thomas Wrba, Magda Diab-Elschahawi
OBJECTIVES: There is limited published data concerning recent epidemiology of urinary tract infections (UTI) in HIV-patients, thus we analysed independent risk factors for UTI in HIV positive individuals and antimicrobial resistance rates of E. coli to antimicrobial agents commonly used in UTI. To determine the prevalence of symptomatic urinary tract infections (UTI) in HIV-patients we performed a retrospective case-control study. METHODS: We included 313 HIV-patients, 101 with UTI and 212 age and gender matched controls, attending the HIV outpatient clinic at the Vienna University hospital (VUH) over a period from January 2011 to September 2016...
April 5, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#16
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29618649/brain-large-artery-lymphocytic-inflammation-and-human-immunodeficiency-virus-related-brain-arterial-remodeling
#17
Adele Shenoy, Andrew Dwork, Mitchell S V Elkind, Randolph Marshall, Susan Morgello, Jose Gutierrez
The pathogenesis of increased stroke risk in Human Immunodeficiency Virus (HIV) remains unclear. Our study investigated the relationship between adventitial and intimal CD3+ T cells and brain arterial remodeling that potentially contributes to HIV-related vasculopathy and stroke. Large brain arteries from 84 HIV+ cases and 78 HIV- cases were analyzed to determine interadventitial and luminal diameters, intimal and wall thickness, percentage stenosis, and presence of atherosclerosis. Immunohistochemical analysis was performed to detect and visually score CD3, a pan T cell marker, in the intima and adventitia...
April 4, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29608231/is-home-based-hiv-testing-universally-acceptable-findings-from-a-case-control-study-nested-within-the-hptn-071-popart-trial
#18
Kalpana Sabapathy, C Mulubwa, H Mathema, C Mubekapi-Musadaidzwa, A Schaap, G Hoddinott, James Hargreaves, Sian Floyd, Helen Ayles, Richard Hayes
OBJECTIVE: The HPTN 071 (PopART) trial is examining the impact of a package including universal testing and treatment on community-level HIV-incidence in Zambia and South Africa. We conducted a nested case-control study to examine factors associated with acceptance of home-based HIV testing and counselling (HB-HTC) delivered by Community HIV-care Providers (CHiPs) in PopART intervention communities. METHODS: Of 295,447 individuals who were offered testing, random samples of individuals who declined HB-HTC (cases) and accepted HB-HTC (controls), stratified by gender and community, were selected...
April 2, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29605829/home-based-care-and-perceived-quality-of-life-among-people-living-with-hiv-in-ho-chi-minh-city-viet-nam
#19
Quyen Thi Tu Bui, Deborah Bain Brickley, Van Thi Thu Tieu, Nancy K Hills
We conducted a cross-sectional study to examine the perceptions of quality of life among people living with HIV who received home-based care services administered through outpatient clinics in Ho Chi Minh City, Viet Nam. Data were collected from a sample of 180 consecutively selected participants (86 cases, 94 controls) at four outpatient clinics, all of whom were on antiretroviral therapy. Quality of life was evaluated using the WHOQOL-BREF instrument. In adjusted analysis, those who received home-based care services had a quality of life score 4...
March 31, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29601591/jail-an-unappreciated-medical-home-assessing-the-feasibility-of-a-strengths-based-case-management-intervention-to-improve-the-care-retention-of-hiv-infected-persons-once-released-from-jail
#20
Anne C Spaulding, Ana Drobeniuc, Paula M Frew, Tiffany L Lemon, Emeli J Anderson, Colin Cerwonka, Chava Bowden, John Freshley, Carlos Del Rio
BACKGROUND: Linkage to and retention in care for US persons living with HIV (PLWH) after release from jail usually declines. We know of no rigorously evaluated behavioral interventions that can improve this. We hypothesized that a strengths-based case management intervention that we developed for PLWH leaving jail would increase linkage/retention in care (indicated by receipt of laboratory draws) and a suppressed HIV viral load (VL) in the year following release. METHODS AND FINDINGS: We conducted a quasi-experimental feasibility study of our intervention for PLWH jailed in Atlanta...
2018: PloS One
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