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HIV case control study

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https://www.readbyqxmd.com/read/28445088/predicting-the-need-for-third-line-antiretroviral-therapy-by-identifying-patients-at-high-risk-for-failing-second-line-antiretroviral-therapy-in-south-africa
#1
Dorina Onoya, Cornelius Nattey, Eric Budgell, Liudmyla van den Berg, Mhairi Maskew, Denise Evans, Kamban Hirasen, Lawrence C Long, Matthew P Fox
Although third-line antiretroviral therapy (ART) is available in South Africa's public sector, its cost is substantially higher than first and second line. Identifying risk factors for failure on second-line treatment remains crucial to reduce the need for third-line drugs. We conducted a case-control study including 194 adult patients (≥18 years; 70 cases and 124 controls) who initiated second-line ART in Johannesburg, South Africa. Unconditional logistic regression was used to assess predictors of virologic failure (defined as 2 consecutive viral load measures ≥1000 copies/mL, ≥3 months after switching to second line)...
April 26, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28444513/in-vitro-fertilization-when-men-women-or-both-partners-are-positive-for-hiv-a-case-control-study
#2
Pauline Vankerkem, Yannick Manigart, Annick Delvigne, Lieveke Ameye, Deborah Konopnicki, Chloë Shaw-Jackson, Serge Rozenberg, Candice Autin
PURPOSE: The aim of this study was to compare the outcomes of in vitro fertilization (IVF) for couples where one or both partners were positive for the human immunodeficiency virus (HIV) to matched control couples. METHODS: A matched case-control retrospective study was performed. Data for 104 couples where the woman was HIV-positive; for 90 couples where the man was HIV-positive; and for 33 couples where both partners were HIV-positive were prospectively analyzed in comparison to matched controls treated in our center during the same period...
April 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#3
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438187/prevention-of-cervical-cancer-in-hiv-seropositive-women-from-developing-countries-a-systematic-review-protocol
#4
Witness Mapanga, Ahmed Elhakeem, Shingairai A Feresu, Fresier Maseko, Tsungai Chipato
BACKGROUND: Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However, the literature on cervical cancer prevention in seropositive women in developing countries has not been reviewed. The aim of this study is to systematically review cervical cancer prevention modalities available for HIV-seropositive women in developing countries. METHODS/DESIGN: This protocol was developed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and the systematic review will be reported in accordance with the PRISMA guidelines...
April 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28437431/factors-associated-with-acquired-anti-ifn-%C3%AE-autoantibody-in-patients-with-nontuberculous-mycobacterial-infection
#5
Pakpoom Phoompoung, Nasikarn Ankasekwinai, Manop Pithukpakorn, Suporn Foongladda, Pinklow Umrod, Bhoom Suktitipat, Surakameth Mahasirimongkol, Sasisopin Kiertiburanakul, Yupin Suputtamongkol
BACKGROUND: The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody to Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors of this syndrome remain unknown. METHOD: We performed an unmatched case control study among patients with NTM diseases who were diagnosed and treated at Siriraj Hospital, Bangkok, Thailand...
2017: PloS One
https://www.readbyqxmd.com/read/28420266/lessons-learned-from-the-field-testing-of-healthy-love-an-hiv-prevention-intervention-for-black-women
#6
Carla A Galindo, Tai E Few, Brandy Daniels, Carolyn P Parks, Dázon D Diallo, L Nyrobi N Moss, Aisha L Wilkes, G Chezia Carraway
BACKGROUND: Healthy Love is a brief, highly interactive, single-session, group-level HIV prevention intervention designed for African American women that is effective at reducing sex risk behaviors and increasing condom use and HIV testing among participants. The Centers for Disease Control and Prevention, through a contract, developed a user-friendly intervention package that would allow organizations to adopt and implement Healthy Love with fidelity. METHOD: Training and implementation materials were developed to support original research protocols, and piloted and revised to conduct field-testing with case study agencies (CSAs)...
May 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28419277/prevention-of-tb-using-rifampicin-plus-isoniazid-reduces-nevirapine-concentrations-in-hiv-exposed-infants
#7
Helen McIlleron, Paolo Denti, Silvia Cohn, Fildah Mashabela, Jennifer D Hoffmann, Saba Shembe, Regina Msandiwa, Lubbe Wiesner, Sithembiso Velaphi, Sanjay G Lala, Richard E Chaisson, Neil Martinson, Kelly E Dooley
Background: Newborns of HIV-infected mothers are given daily doses of nevirapine to prevent HIV-1 acquisition. Infants born to mothers with TB should also receive TB preventive therapy. TB preventive regimens include isoniazid for 6 months or rifampicin plus isoniazid for 3 months (RH preventive therapy). The effect of concomitant RH preventive therapy on nevirapine concentrations in infants is unknown. Patients and methods: Tshepiso was a prospective case-control cohort study of pregnant HIV-infected women with and without TB whose newborn infants received standard doses of nevirapine for HIV prophylaxis...
April 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28414762/transcriptional-networks-are-associated-with-resistance-to-mycobacterium-tuberculosis-infection
#8
Chetan Seshadri, Nafiseh Sedaghat, Monica Campo, Glenna Peterson, Richard D Wells, Gregory S Olson, David R Sherman, Catherine M Stein, Harriet Mayanja-Kizza, Ali Shojaie, W Henry Boom, Thomas R Hawn
RATIONALE: Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV. OBJECTIVES: To compare the early transcriptional response of M.tb-infected monocytes between Ugandan household contacts of tuberculosis patients who demonstrate clinical resistance to M.tb infection (cases) and matched controls with latent tuberculosis infection. METHODS: Cases (n = 10) and controls (n = 18) were selected from a long-term household contact study in which cases did not convert their tuberculin skin test (TST) or develop tuberculosis over two years of follow up...
2017: PloS One
https://www.readbyqxmd.com/read/28414260/retention-in-hiv-care-and-viral-suppression-individual-and-neighborhood-level-predictors-of-racial-ethnic-differences-florida-2015
#9
Diana M Sheehan, Kristopher P Fennie, Daniel E Mauck, Lorene M Maddox, Spencer Lieb, Mary Jo Trepka
The objective of this study was to estimate racial/ethnic differences in retention in HIV care and viral suppression and to identify related individual and neighborhood determinants. Florida HIV surveillance records of cases aged ≥13 years diagnosed during the years 2000-2014 were analyzed. Retention in care was defined as evidence of ≥2 or more laboratory tests, receipts of prescription, or clinical visits at least 3 months apart during 2015. Viral load suppression was defined as a viral load of <200 copies/mL for the last test in 2015...
April 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28413168/prevalence-of-hiv-hbv-and-hcv-and-related-risk-factors-amongst-male-homeless-people-in-lorestan-province-the-west-of-iran
#10
Amin Doosti-Irani, Hamid Mokhaeri, Ali Chegini Sharafi, Mohammad Reza Aghasadeghi, Morteza Hajimiragha, Mohammad Saki, Mohammad Hassan Kayedi, Ehsan Mostafavi
BACKGROUND: Homeless people are at a higher risk of blood-born infectious diseases. The aim of this study was to estimate the prevalence of HIV, HBV, HCV and related risk factors among male homeless people. STUDY DESIGN: A cross-sectional study. METHODS: This study was conducted in Khorramabad City, western Iran from January to June 2015. A pre-designed validated questionnaire was used to collect the data on behavioral and other potential risk factors...
March 11, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28410692/treatment-outcome-of-extrapulmonary-tuberculosis-under-revised-national-tuberculosis-control-programme
#11
J J Cherian, I Lobo, A Sukhlecha, U Chawan, N A Kshirsagar, B L Nair, L Sawardekar
BACKGROUND: Extrapulmonary tuberculosis (EPTB) constitutes 15-20% of tuberculosis cases in India. Earlier studies have evaluated treatment outcomes of EPTB with little information on outcomes of individual site of EPTB. AIMS: The objective was to study the outcome of Directly Observed Treatment Short course (DOTS) treatment of EPTB in different organ systems under Revised National Tuberculosis Control Programme. METHODS: Multi-centric retrospectives record review was carried out in three states in India...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28409005/plasma-sphingolipids-in-hiv-associated-chronic-obstructive-pulmonary-disease
#12
Shane Hodgson, Timothy J Griffin, Cavan Reilly, Stephen Harvey, Bruce A Witthuhn, Brian J Sandri, Ken M Kunisaki, Chris H Wendt
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity in persons living with HIV (PLWH) and HIV appears to uniquely cause COPD, independent of smoking. The mechanisms by which HIV leads to COPD are not clear. The objective of this study was to identify metabolomic biomarkers and potential mechanistic pathways of HIV-associated COPD (HIV-COPD). METHODS: We performed case-control metabolite profiling via mass spectrometry in plasma from 38 individuals with HIV-COPD (cases), comparing to matched controls with/without HIV and with/without COPD...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28407044/health-insurance-type-and-control-of-hypertension-among-us-women-living-with-and-without-hiv-infection-in-the-women-s-interagency-hiv-study
#13
Christina Ludema, Stephen R Cole, Joseph J Eron, G Mark Holmes, Kathryn Anastos, Jennifer Cocohoba, Marge H Cohen, Hannah L F Cooper, Elizabeth T Golub, Seble Kassaye, Deborah Konkle-Parker, Lisa Metsch, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Health care access is an important determinant of health. We assessed the effect of health insurance status and type on blood pressure control among US women living with (WLWH) and without HIV. METHODS: We used longitudinal cohort data from the Women's Interagency HIV Study (WIHS). WIHS participants were included at their first study visit since 2001 with incident uncontrolled blood pressure (BP) (i.e., BP ≥140/90 and at which BP at the prior visit was controlled (i...
April 12, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28406806/improved-hiv-and-tb-knowledge-and-competence-among-mid-level-providers-in-a-cluster-randomized-trial-of-one-on-one-mentorship-for-task-shifting
#14
Sarah Naikoba, Kaggwa Dan Senjovu, Pallen Mugabe, Carey McCarthy, Patricia L Riley, Damazo Trevor Kadengye, Shona Dalal
INTRODUCTION: Health worker shortages pose a challenge to the scale-up of HIV care and treatment in Uganda. Training mid-level providers (MLP) in the provision of HIV and TB treatment can expand existing health workforce capacity and access to HIV services. METHODS: We conducted a cluster-randomized trial of, on-site clinical mentorship for HIV and TB care at 10 health facilities in rural Uganda. Twenty MLP and were randomly assigned to an intervention of eight hours a week of one on one mentorship, every six weeks over a nine month period; and another twenty to the control of no clinical mentorship...
April 12, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28406423/epidemiological-aspects-of-genital-ulcers-at-the-sti-center-of-the-national-institute-of-public-hygiene-abidjan-c%C3%A3-te-d-ivoire-2008-to-2010
#15
D Z Gakoué, I Tiembré
Genital ulcers are among the seven syndromes of sexually transmitted infections (STIs) identified in Côte d'Ivoire. Ulcerative STIs present a public health problem because of their frequency and their role in the spread of HIV. Our objective was to investigate the epidemiological characteristics of genital ulcers observed in the STI center of the National Institute of Public Hygiene in Abidjan. This cross-sectional, descriptive and analytical study examined cases seen at the center in 2008 through 2010. We retrospectively reviewed all files of clients aged 10 and older who sought care for the first time at the STI center and received a clinical diagnosis, confirmed by the laboratory, of a STI...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28404854/autologous-stem-cell-transplantation-disrupts-adaptive-immune-responses-during-rebound-shiv-viremia
#16
Daniel B Reeves, Christopher W Peterson, Hans-Peter Kiem, Joshua T Schiffer
Primary HIV-1 infection induces a virus-specific adaptive/cytolytic immune response that impacts plasma viral load setpoint and rate of progression to AIDS. Combination antiretroviral therapy (cART) suppresses plasma viremia to undetectable levels that rebound upon cART treatment interruption. Following cART withdrawal, the memory component of the virus-specific adaptive immune response may improve viral control compared to primary infection. Here, using primary infection and treatment interruption data from macaques infected with simian/human immunodeficiency virus (SHIV), we observe lower peak viral load but unchanged viral setpoint during viral rebound...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28404135/incidence-risk-factors-and-prevention-of-hepatitis-c-reinfection-a-population-based-cohort-study
#17
Nazrul Islam, Mel Krajden, Jean Shoveller, Paul Gustafson, Mark Gilbert, Jane A Buxton, Jason Wong, Mark W Tyndall, Naveed Zafar Janjua
BACKGROUND: People remain at risk of reinfection with hepatitis C virus (HCV), even after clearance of the primary infection. We identified factors associated with HCV reinfection risk in a large population-based cohort study in British Columbia, Canada, and examined the association of opioid substitution therapy and mental health counselling with reinfection. METHODS: We obtained data from the British Columbia Hepatitis Testers Cohort, which includes all individuals tested for HCV or HIV at the British Columbia Centre for Disease Control Public Health Laboratory during 1990-2013 (when data were available)...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403825/disparities-in-hiv-and-syphilis-prevalence-and-risk-factors-between-older-male-clients-with-and-without-steady-sex-partners-in-southwestern-rural-china
#18
Li Chen, Jenny H His, Xinghua Wu, Zhiyong Shen, Huaxiang Lu, Huanhuan Chen, Hui Huang, Heng Zhang, Yuhua Ruan, Yiming Shao, Zhenzhu Tang
BACKGROUND: Heterosexual intercourse accounted for 93% of reported HIV cases in Guangxi, and Guangxi had 10% of China's total number of reported HIV cases. Older men are particularly vulnerable to STIs, for example, 46% of Guangxi's HIV cases were men over 50 years of age. As this is an under-studied population in China, effective prevention and control policies have yet to be developed. Thus, the aim of this study was to use a large-scale cross-sectional survey to understand the demographic and behavior factors associated with HIV and syphilis infections among older male clients of female sex workers (FSWs) in a high epidemic area of rural Guangxi, China...
April 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28403272/examining-hiv-viral-load-in-a-matched-cohort-of-hiv-positive-individuals-with-and-without-psoriasis
#19
Jashin J Wu, Kathleen E Gilbert, Michael Batech, Iviensan F Manalo, William J Towner, Rui André Saraiva Raposo, Douglas F Nixon, Wilson Liao
<p>BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients.</p> <p>OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis.</p> <p>METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28399800/tst-positivity-in-household-contacts-of-tuberculosis-patients-a-case-contact-study-in-malawi
#20
Jonas Hector, Suzanne T Anderson, Gertrude Banda, Mercy Kamdolozi, Laura F Jefferys, Doris Shani, Natalie J Garton, Agnes Mwale, Annie Jobe, Geraint R Davies, Derek J Sloan
BACKGROUND: Screening household contacts of active tuberculosis (TB) patients is recommended for TB control. Due to resource constraints this rarely occurs in lower income countries. Demographic and clinical features of index cases may influence the likelihood of onwards TB transmission. It has also been proposed that accumulation of intracellular lipid bodies within M. tuberculosis cells may also enhance bacterial transmissibility. This study explored whether clinical and bacteriological observations recorded at baseline in TB cases in Malawi could help identify those with the highest risk of onwards transmission, to prioritise contact tracing...
April 11, 2017: BMC Infectious Diseases
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