keyword
MENU ▼
Read by QxMD icon Read
search

HIV case control study

keyword
https://www.readbyqxmd.com/read/29439467/blood-mitochondrial-dna-content-in-hiv-exposed-uninfected-children-with-autism-spectrum-disorder
#1
Matthew A Budd, Kristina Calli, Lindy Samson, Jennifer Bowes, Anthony Y Y Hsieh, John C Forbes, Ari Bitnun, Joel Singer, Fatima Kakkar, Ariane Alimenti, Evelyn J Maan, M E Suzanne Lewis, Carole Gentile, Hélène C F Côté, Jason C Brophy
Long-term outcomes of perinatal exposure to maternal antiretroviral therapy in HIV-exposed uninfected (HEU) children are unknown. However, both HIV antiretroviral therapy and autism spectrum disorder (ASD) have been associated with mitochondrial alterations. Leukocyte mitochondrial DNA (mtDNA) content can serve as a marker for mitochondrial dysfunction. In this cross-sectional, nested case-control study, HEU children with ASD were matched approximately 1:3 on age, sex, and ethnicity to HEU children without ASD, HIV-unexposed uninfected (HUU) controls, and HUU children with ASD...
February 11, 2018: Viruses
https://www.readbyqxmd.com/read/29438413/spatial-overlap-links-seemingly-unconnected-genotype-matched-tb-cases-in-rural-uganda
#2
Gabriel Chamie, Midori Kato-Maeda, Devy M Emperador, Bonnie Wandera, Olive Mugagga, John Crandall, Michael Janes, Carina Marquez, Moses R Kamya, Edwin D Charlebois, Diane V Havlir
INTRODUCTION: Incomplete understanding of TB transmission dynamics in high HIV prevalence settings remains an obstacle for prevention. Understanding where transmission occurs could provide a platform for case finding and interrupting transmission. METHODS: From 2012-2015, we sought to recruit all adults starting TB treatment in a Ugandan community. Participants underwent household (HH) contact investigation, and provided names of social contacts, sites of work, healthcare and socializing, and two sputum samples...
2018: PloS One
https://www.readbyqxmd.com/read/29427049/favourable-outcome-in-a-child-with-symptomatic-diagnosis-of-glutaric-aciduria-type-1-despite-vertical-hiv-infection-and-minor-head-trauma
#3
Angeline Thomas, Els F M Dobbels, Priscilla E Springer, Christelle Ackermann, Mark F Cotton, Barbara Laughton
The first case of Glutaric aciduria Type 1(GA1) in an African child was reported in 2001. GA1 has a prevalence of 1:5000 in black South Africans. Although early diagnosis is essential for a favourable outcome, newborn screening is not routine in South Africa where an estimated 320,000 children have HIV infection. Neurodevelopmental delay and encephalopathy are complications of both HIV and GA1. In such a setting it is important to recognise that HIV and GA1 can occur simultaneously. We present an HIV-infected South African male child of Xhosa descent with macrocephaly who commenced combination antiretroviral therapy (ART) at 8 weeks of age in a clinical trial which included a neurodevelopmental sub-study...
February 9, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29424776/a-prospective-study-of-serum-microbial-translocation-biomarkers-and-risk-of-aids-related-non-hodgkin-lymphoma
#4
Marta Epeldegui, Larry Magpantay, Yu Guo, Gordana Halec, William G Cumberland, Priscilla K Yen, Bernard Macatangay, Joseph B Margolick, Anne F Rositch, Steven Wolinsky, Otoniel Martinez-Maza, Shehnaz K Hussain
: Chronic immune activation is a harbinger of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL), yet the underlying basis is unclear. Microbial translocation, the passage of microbial components from the gastrointestinal tract into the systemic circulation, is a source of systemic immune activation in HIV infection and may be an important contributor to the chronic B-cell activation and subsequent AIDS-NHL development. We measured biomarkers of microbial translocation including bacterial receptors/antibodies, intestinal barrier proteins, and macrophage activation-associated cytokines/chemokines, in serum from 200 HIV-infected men from the Multicenter AIDS Cohort Study prior to their AIDS-NHL diagnosis (mean = 3...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29424001/use-of-trimethoprim-sulfamethoxazole-during-pregnancy-and-risk-of-spontaneous-abortion-a-nested-case-control-study
#5
Flory T Muanda, Odile Sheehy, Anick Bérard
AIMS: Data available on the fetal safety of trimethoprim-sulfamethoxazole exposure during pregnancy remains scarce and inconclusive. A previous study assessing the link between use TMP-SMX exposure during pregnancy and the risk of spontaneous abortion (SA) did not control for protopathic bias and indication bias. METHODS: We conducted a nested control study (n= 77 429 pregnancies including 7039 cases of SA and 70 390 controls) within the Quebec Pregnancy Cohort...
February 8, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29420545/association-of-gene-polymorphism-of-sdf1-cxcr12-with-susceptibility-to-hiv-1-infection-and-aids-disease-progression-a-meta-analysis
#6
Jiwei Ding, Jianyuan Zhao, Jinming Zhou, Xiaoyu Li, Yanbin Wu, Mei Ge, Shan Cen
OBJECTIVES: Genetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies. METHODS: Articles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29396006/evaluation-of-the-association-between-the-concentrations-of-key-vaginal-bacteria-and-the-increased-risk-of-hiv-acquisition-in-african-women-from-five-cohorts-a-nested-case-control-study
#7
R Scott McClelland, Jairam R Lingappa, Sujatha Srinivasan, John Kinuthia, Grace C John-Stewart, Walter Jaoko, Barbra A Richardson, Krista Yuhas, Tina L Fiedler, Kishorchandra N Mandaliya, Matthew M Munch, Nelly R Mugo, Craig R Cohen, Jared M Baeten, Connie Celum, Julie Overbaugh, David N Fredricks
BACKGROUND: Disruptions of vaginal microbiota might increase women's susceptibility to HIV infection. Advances in molecular microbiology have enabled detailed examination of associations between vaginal bacteria and HIV acquisition. Therefore, this study aimed to evaluate the association between the concentrations of specific vaginal bacteria and increased risk of HIV acquisition in African women. METHODS: We did a nested case-control study of participants from eastern and southern Africa...
January 25, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29394247/health-and-socio-demographic-profile-of-women-of-reproductive-age-in-rural-communities-of-southern-mozambique
#8
Charfudin Sacoor, Beth Payne, Orvalho Augusto, Faustino Vilanculo, Ariel Nhacolo, Marianne Vidler, Prestige Tatenda Makanga, Khátia Munguambe, Tang Lee, Eusébio Macete, Peter von Dadelszen, Esperança Sevene
Reliable statistics on maternal morbidity and mortality are scarce in low and middle-income countries, especially in rural areas. This is the case in Mozambique where many births happen at home. Furthermore, a sizeable number of facility births have inadequate registration. Such information is crucial for developing effective national and global health policies for maternal and child health. The aim of this study was to generate reliable baseline socio-demographic information on women of reproductive age as well as to establish a demographic surveillance platform to support the planning and implementation of the Community Level Intervention for Pre-eclampsia (CLIP) study, a cluster randomized controlled trial...
2018: PloS One
https://www.readbyqxmd.com/read/29390909/colpocytological-abnormalities-in-hiv-infected-and-uninfected-pregnant-women-prevalence-persistence-and-progression
#9
Carmine Carriero, Fabiana Divina Fascilla, Paola Cramarossa, Achiropita Lepera, Stefano Bettocchi, Antonella Vimercati
In this retrospective case-control study, we analyse data of 48 HIV-positive pregnant patients, versus a control group of 99 HIV-negative pregnant women, followed as outpatients by our department from 2009 to 2014. The aims of the study were to investigate the prevalence, persistence and progression of cervical squamous intraepithelial lesions (SIL) in each group and to correlate colpo-cytological lesions to the socio-demographic and clinical-laboratory findings in the HIV + pregnant women. In our study we observed that immunosuppression, HPV infection and vaginal coinfections were predictive of cervical lesions...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29381125/talking-about-sex-in-pregnancy-reflections-from-the-field-in-urban-south-africa
#10
Langelihle Mlotshwa, Lenore Manderson, Charles Chasela, Sonja Merten
Qualitative research with close engagement in the field allows researchers and participants to build relationships and establish trust, enabling researchers to collect meaningful and sensitive information. Drawing on findings from a study conducted in an urban setting in South Africa, we discuss the challenges faced when interviewing pregnant women with HIV infection, retaining them in the study, and extending the study to include their partners. We discuss the dynamics of pregnancy and draw lessons from interviews concerned with personal, sensitive issues...
January 30, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29378042/vitamin-e-status-is-inversely-associated-with-risk-of-incident-tuberculosis-disease-among-household-contacts
#11
Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray
Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression. Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru...
January 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29370864/leishmaniasis-in-sri-lanka-spatial-distribution-and-seasonal-variations-from-2009-to-2016
#12
REVIEW
Lahiru Sandaruwan Galgamuwa, Samath D Dharmaratne, Devika Iddawela
BACKGROUND: Leishmaniasis is listed as one of the eight neglected tropical diseases by the World Health Organization and the number of cases in endemic areas has seen a sharp rise in the past decade. More alarmingly, reports have shown that leishmaniasis is spreading to non-endemic areas of the world due to co-infection with HIV. In Sri Lanka, leishmaniasis is considered as a notifiable disease from 2008 and has seen a rising trend of incidence since then. This is the first study describing the burden, seasonal variation and spatial distribution of leishmaniasis in Sri Lanka since the disease has been included as a notifiable disease...
January 25, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29370853/treatment-of-cervical-cancer-in-hiv-seropositive-women-from-developing-countries-a-protocol-for-a-systematic-review
#13
Witness Mapanga, Tsungai Chipato, Shingairai A Feresu
BACKGROUND: Cervical cancer has become the most common cancer affecting women in Africa. Significantly, 85% of these annual deaths occur in the developing world, with the majority being middle-aged women. Research has shown that in sub-Saharan Africa, cervical cancer trends are on the rise in the past two decades because of HIV and this has resulted in an increase in cervical cancer cases among young women. However, little or no information exists that has shown that any of the available treatment methods are more effective than others when it comes to treating cervical cancer in HIV-seropositive women...
January 25, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29370775/case-report-mechanisms-of-hiv-elite-control-in-two-african-women
#14
Yumna Moosa, Ramla F Tanko, Veron Ramsuran, Ravesh Singh, Mashudu Madzivhandila, Nonhlanhla Yende-Zuma, Melissa-Rose Abrahams, Philippe Selhorst, Kamini Gounder, Penny L Moore, Carolyn Williamson, Salim S Abdool Karim, Nigel J Garrett, Wendy A Burgers
BACKGROUND: The majority of people living with HIV require antiretroviral therapy (ART) for controlling viral replication, however there are rare HIV controllers who spontaneously and durably control HIV in the absence of treatment. Understanding what mediates viral control in these individuals has provided us with insights into the immune mechanisms that may be important to induce for a vaccine or functional cure for HIV. To date, few African elite controllers from high incidence settings have been described...
January 25, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29370196/lower-pre-art-intra-participant-hiv-1-pol-diversity-may-not-be-associated-with-virologic-failure-in-adults
#15
Mary F Kearney, Jonathan Spindler, Ann Wiegand, Wei Shao, Richard Haubrich, Sharon Riddler, Christina M Lalama, Michael D Hughes, John M Coffin, John W Mellors
BACKGROUND: Identifying pre-ART factors associated with the emergence of HIV-1 drug resistance is critical for optimizing strategies to prevent virologic failure. A previous study reported that lower pre-ART HIV-1 pol diversity was associated with higher risk of virologic failure in HIV-1-infected children. To investigate this association in adults, we measured HIV-1 diversity with deep sequencing in pre-ART samples from adults with well-characterized virologic outcomes in a study (A5142) of initial ART conducted by the AIDS Clinical Trials Group (ACTG)...
2018: PloS One
https://www.readbyqxmd.com/read/29368537/superior-efficacy-and-improved-renal-and-bone-safety-after-switching-from-a-tenofovir-disoproxil-fumarate-tdf-to-a-tenofovir-alafenamide-taf-based-regimen-through-96-weeks-of-treatment
#16
Edwin DeJesus, Bernard Haas, Sorana Segal-Mauer, Moti Ramgopal, Anthony Mills, Nicolas Margot, Ya-Pei Liu, Tariro Makadzange, Scott McCallister
BACKGROUND: We previously demonstrated superior efficacy and safety advantages in HIV-infected, virologically suppressed adults switched to a regimen containing tenofovir alafenamide (TAF) as compared with those remaining on a tenofovir disoproxil fumarate (TDF) regimen through week 48. We now report longer-term data through week 96. METHODS: In this randomized, active-controlled, multicenter, open-label, non-inferiority trial (ClinicalTrials.gov number NCT01815736), we randomized virologically suppressed (HIV-1 RNA <50 copies/mL) adults (2:1) to receive a once-daily, single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (TAF group) or to continue one of four TDF-containing regimens (TDF group) for 96 weeks...
January 25, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29351766/efficacy-and-safety-of-sofosbuvir-containing-regimens-in-patients-co-infected-with-chronic-hepatitis-c-virus-and-human-immunodeficiency-virus-a-meta-analysis
#17
Guotao Li, Ke Zang, Guoqiang Zhang, Danyan Zhu, Xiaozhao Deng
BACKGROUND: The treatment of hepatitis C virus (HCV) in HCV/human immunodeficiency virus (HIV) co-infected patients remains complex. This present meta-analysis evaluated the efficacy and safety of Sofosbuvir (SOF) for treatment in HCV/HIV co-infected patients using the most recent and available data. METHODS: A systematic search of the published data was conducted in PubMed Medline, EMBASE and Cochrane databases. Eligible studies were clinical trials, case-control studies or prospective cohort studies aiming at assessing the efficacy and safety of the SOF-containing regimens in patients co-infected with HCV and HIV...
January 19, 2018: Virology Journal
https://www.readbyqxmd.com/read/29338738/rapid-hiv-disease-progression-following-superinfection-in-an-hla-b-27-05-b-57-01-positive-transmission-recipient
#18
Jacqui Brener, Astrid Gall, Jacob Hurst, Rebecca Batorsky, Nora Lavandier, Fabian Chen, Anne Edwards, Chrissy Bolton, Reena Dsouza, Todd Allen, Oliver G Pybus, Paul Kellam, Philippa C Matthews, Philip J R Goulder
BACKGROUND: The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in < 3 years. RESULTS: The rapid progressor was the recipient within a known transmission pair, enabling virus sequences to be tracked from transmission...
January 16, 2018: Retrovirology
https://www.readbyqxmd.com/read/29324463/fractures-related-to-tenofovir-a-case-noncase-study-in-the-european-pharmacovigilance-database
#19
Montserrat G García, Unai Larrinaga-Torrontegui, Eduardo Eduardo Martinez, Unax Lertxundi, Itziar Palacios-Zabalza, Carmelo Aguirre
BACKGROUND: There is no clear consensus on the relationship between tenofovir (TDF) and fracture risk because the studies published so far present contradictory findings. STUDY QUESTION: Our objective was to detect, from the European pharmacovigilance database (EudraVigilance), a signal of fracture risk during TDF exposure in patients infected with HIV. METHODS: Herein, we analyze all the cases of fractures suspected to be related to TDF recorded in EudraVigilance between 2001 and November 10, 2016...
January 8, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29318120/beyond-morality-assessment-of-the-capacity-of-faith-based-organizations-fbos-in-responding-to-the-hiv-aids-challenge-in-southeastern-nigeria
#20
Eze Edlyne Anugwom, Kenechukwu Anugwom
Background: For the world can get rid of the HIV/AIDS pandemic by 2030, there is need for more to be done especially in the case of countries in Africa. In Nigeria, such efforts have included Faith-Based Organizations (FBOs) recognized as partners in the National Response Framework. However, the extent to which these FBOs contribute to efforts to control the pandemic will depend on their capacity. Therefore, this study aimed to ascertain the technical and managerial capacity of these FBOs to respond to the pandemic in Nigeria...
January 2018: Iranian Journal of Public Health
keyword
keyword
98327
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"