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HIV cohort study

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https://www.readbyqxmd.com/read/29912987/performance-of-point-of-care-birth-hiv-testing-in-primary-health-care-clinics-an-observational-cohort-study
#1
Bindiya Meggi, Lara Vojnov, Nedio Mabunda, Adolfo Vubil, Alcina Zitha, Ocean Tobaiwa, Chishamiso Mudenyanga, Dadirayi Mutsaka, Timothy Bollinger, Osvaldo Loquiha, Trevor F Peter, Ilesh V Jani
BACKGROUND: Failure to timely diagnose HIV in infants is a major barrier for scaling-up paediatric antiretroviral treatment (ART). WHO recommends birth testing for earlier diagnosis and to improve test coverage, but current diagnosis takes 2-3 weeks to complete, thereby limiting the ability of care givers to provide follow-on care, especially in low-resource settings. We evaluated the benefit of implementing rapid diagnosis of HIV at birth in primary health care maternity wards in Mozambique...
2018: PloS One
https://www.readbyqxmd.com/read/29912250/-lethality-analysis-in-patients-with-tuberculosis-diagnosis-in-a-high-complexity-hospital-in-cali-colombia
#2
M Alexandra Sánchez, Jessica Pino, Robinson Pacheco, José Fernando García
Background In 2016 tuberculosis (TB) was considered the ninth leading cause of death worldwide and the leading cause of a single infectious agent, with approximately 1.6 million deaths worldwide and a lethality of 15%. Over 95% of cases and deaths are in developing countries like Colombia. AIM: To describe the sociodemographic and clinical characteristics of patients who died during TB treatment in a high complexity hospital in Cali, Colombia. METHODS: We conducted an analytic retrospective cohort during 2007-2016 in Fundación Valle del Lili...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29907624/effect-of-rectal-douching-enema-on-rectal-gonorrhoea-and-chlamydia-among-a-cohort-of-men-who-have-sex-with-men-on-hiv-pre-exposure-prophylaxis
#3
Adiba Hassan, Jill S Blumenthal, Michael P Dube, Eric Ellorin, Katya Corado, David J Moore, Sheldon R Morris
OBJECTIVES: Rectal douching/enema (RD) is a common practice among men who have sex with men (MSM) in preparation for sex. RD can break down the rectal mucosal barrier and potentially affect the rectal microbiome. The objective of this study was to understand if RD is associated with acquiring rectal infections (RI) with rectal gonorrhoea (NG) and/or chlamydia (CT). METHODS: From 2013 to 2015, 395 adult HIV-uninfected MSM were enrolled in a randomised controlled study for pre-exposure prophylaxis (PrEP) adherence with routine sexual risk survey and testing...
June 15, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29907532/relationship-between-medication-synchronization-and-antiretroviral-adherence
#4
Emily Ghassemi, Jennifer Smith, Laura Owens, Charles Herring, Melissa Holland
OBJECTIVES: To compare antiretroviral adherence (measured as the proportion of days covered [PDC]) and change in viral load in insured, HIV-infected, adult outpatients enrolled and not enrolled in a medication synchronization program. METHODS: This was a multicenter, retrospective, pilot cohort study. Fifty-eight insured, HIV-infected, outpatients at least 18 years of age receiving antiretroviral therapy (ART) for at least 3 months as of August 2015 were included...
June 12, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29906660/prevalence-of-cervical-oral-and-anal-human-papillomavirus-infection-in-women-living-with-hiv-in-denmark-the-shade-cohort-study
#5
Kristina Thorsteinsson, Merete Storgaard, Terese L Katzenstein, Steen Ladelund, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Anne Gaardsting, Lars Nørregård Nielsen, Jesper Bonde, Anne-Mette Lebech
BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection...
May 25, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29906495/hiv-infection-across-aging-synergistic-effects-on-intrinsic-functional-connectivity-of-the-brain
#6
Anna R Egbert, Bharat Biswal, Keerthana Karunakaran, Agnieszka Pluta, Tomasz Wolak, Stephen Rao, Robert Bornstein, Bogna Szymańska, Andrzej Horban, Ewa Firląg-Burkacka, Marta Sobańska, Natalia Gawron, Przemysław Bieńkowski, Halina Sienkiewicz-Jarosz, Anna Ścińska-Bieńkowska, Emilia Łojek
The objective of the study was to examine additive and synergistic effects of age and HIV infection on resting state (RS) intra- and inter-network functional connectivity (FC) of the brain. We also aimed to assess relationships with neurocognition and determine clinical-, treatment-, and health-related factors moderating intrinsic brain activity in aging HIV-positive (HIV+) individuals. The current report presents data on 54 HIV+ individuals (age M = 41, SD = 12 years) stabilized on cART and 54 socio-demographically matched healthy (HIV-) comparators (age M = 43, SD = 12 years), with cohort education mean of 16 years (SD = 12)...
June 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29906263/maternal-peripartum-serum-ddt-e-and-urinary-pyrethroid-metabolite-concentrations-and-child-infections-at-2-years-in-the-vhembe-birth-cohort
#7
Jonathan Huang, Brenda Eskenazi, Riana Bornman, Stephen Rauch, Jonathan Chevrier
BACKGROUND: Indoor residual spraying (IRS) of insecticides, conducted in low- and middle-income countries to control malaria, may result in high exposure to dichlorodiphenyltrichloroethane (DDT), its breakdown product dichlorodiphenyldichloroethylene (DDE), or pyrethroids. Animal studies suggest in utero exposure to these chemicals may increase childhood infection frequency. OBJECTIVES: We investigated associations between maternal DDT/E and pyrethroid metabolite concentration and child infection associations in an IRS setting in which susceptibility factors are common and infections are leading causes of child morbidity and mortality...
June 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29905502/hiv-risk-characteristics-associated-with-violence-against-women-a-longitudinal-study-among-women-in-the-united-states
#8
Brooke E E Montgomery, Paula M Frew, James P Hughes, Jing Wang, Adaora A Adimora, Danielle F Haley, Irene Kuo, Larissa Jennings, Nabila El-Bassel, Sally L Hodder
BACKGROUND: Using data from HIV Prevention Trials Network 064, a multisite, observational cohort study conducted to estimate HIV incidence rates among women living in areas of high poverty and HIV prevalence in the United States, we examined the use of HIV risk characteristics to predict emotional abuse, physical violence, and forced sex. METHODS: Participants included 2099 women, 18-44 years of age, who reported unprotected vaginal or anal sex with a male partner and an additional personal or perceived male partner HIV risk characteristic in the past 6 months...
June 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29903710/analysis-of-drug-drug-interactions-among-patients-receiving-antiretroviral-regimens-using-data-from-a-large-open-source-prescription-database
#9
Nimish Patel, Peter Borg, Richard Haubrich, Ian McNicholl
PURPOSE: Results of a study of contraindicated concomitant medication use among recipients of preferred antiretroviral therapy (ART) regimens are reported. METHODS: A retrospective study was conducted to evaluate concomitant medication use in a cohort of previously treatment-naive, human immunodeficiency virus (HIV)-infected U.S. patients prescribed preferred ART regimens during the period April 2014-March 2015. Data were obtained from a proprietary longitudinal prescription database; elements retrieved included age, sex, and prescription data...
June 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29902251/comparison-of-two-screening-tests-for-hiv-associated-neurocognitive-disorder-suspected-japanese-patients-with-respect-to-cart-usage
#10
Kaoru Kami-Onaga, Masao Tateyama, Takeshi Kinjo, Gretchen Parrott, Daisuke Tominaga, Ai Takahashi-Nakazato, Hideta Nakamura, Daisuke Tasato, Kyoko Miyagi, Saori Maeda, Hirotaka Arae, Hitoshi Uehara, Kazuya Miyagi, Shusaku Haranaga, Jiro Fujita
In this study, we demonstrated the pervasiveness of HIV-associated neurocognitive disorders (HAND) among a selection of Japanese patients as well as evaluated and compared the Mini Mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS) for use as a screening tool among combination anti-retroviral therapy (cART)-naïve and cART experienced patients. The MMSE and the IHDS have both been used as HAND screening tests around the world with variable success. It has been reported the increased usage of cART the utility of these screening tests may have been diminished due to the decreased severity of impairment and the altered pattern of neurocognitive impairments in cART era HAND patients...
2018: PloS One
https://www.readbyqxmd.com/read/29902174/prognostic-value-of-quicksofa-as-a-predictor-of-28-day-mortality-among-febrile-adult-patients-presenting-to-emergency-departments-in-dar-es-salaam-tanzania
#11
Noémie Boillat-Blanco, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, Aline Mamin, Blaise Genton, Laurent Kaiser, Thierry Calandra, Valérie D'Acremont
BACKGROUND: Quick Sequential Organ Failure Assessment (qSOFA) is a three-item clinical instrument for bedside identification of sepsis patients at risk of poor outcome. qSOFA could be a valuable triage tool in emergency departments of low-income countries, yet its performance in resource-limited settings remains unknown. The prognostic accuracy of qSOFA for 28-day all-cause mortality in febrile adults treated at the EDs in a low-income country was evaluated. METHODS: Retrospective analysis of a prospective cohort study of consecutive patients (≥18 years) with fever (tympanic temperature ≥38°C and fever ≤7 days) who presented between July 2013 and May 2014 at four emergency departments in Dar es Salaam, Tanzania...
2018: PloS One
https://www.readbyqxmd.com/read/29901821/risk-of-diabetes-in-hiv-infected-patients-is-associated-with-cirrhosis-but-not-with-chronic-hcv-coinfection-in-a-french-nationwide-hiv-cohort
#12
A Provoost, M Dramé, L Cotte, L Cuzin, R Garraffo, D Rey, F Raffi, I Poizot-Martin, P Pugliese, F Bani-Sadr
BACKGROUND: Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections have been reportedly associated with a higher risk of diabetes mellitus (DM) but results are conflicting. AIMS: To determine whether there is an association between chronic HCV and the incidence of DM, and to study the role of factors such as cirrhosis, IFN-based HCV therapy, sustained virologic response (SVR) and chronic HBV infection among patients living with HIV (PLHIV) followed in a large French multicentre cohort in the combination antiretroviral therapy (cART) era...
June 14, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29901415/early-treatment-of-primary-hiv-infection-is-associated-with-decreased-mortality
#13
Angie Pinto, Patricia Grey, Ansari Shaik, David A Cooper, Anthony D Kelleher, Kathy Petoumenos
BACKGROUND: The aim of this study was to understand factors associated with increased mortality in a cohort of primary HIV infection (PHI) in New South Wales over three decades. METHODS: 602 patients with PHI were enrolled from 1984 to 2009. Probabilistic data linkage was performed to NSW Registry of births deaths and marriages, and Australian Bureau of Statistics mortality database. Mortality was measured by crude death rate. Pre highly active antiretroviral therapy (pre-HAART) era was defined as prior to 1 January 1997...
June 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29898396/co-evolution-of-hiv-envelope-and-apex-targeting-neutralizing-antibody-lineage-provides-benchmarks-for-vaccine-design
#14
Kimmo Rantalainen, Zachary T Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion, Jonathan L Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, Elise Landais, James C Paulson, Ian A Wilson, Andrew B Ward
Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a basis for understanding the co-evolutionary contest between HIV and the humoral immune system. Here, we describe the structural characterization of an apex-targeting antibody lineage and autologous clade A viral Env from a donor in the Protocol C cohort. Comparison of Ab-Env complexes at early and late time points reveals that, within the antibody lineage, the CDRH3 loop rigidifies, the bnAb angle of approach steepens, and surface charges are mutated to accommodate glycan changes...
June 12, 2018: Cell Reports
https://www.readbyqxmd.com/read/29897981/reduction-in-terminally-differentiated-t-cells-in-virologically-controlled-hiv-infected-aging-patients-on-long-term-antiretroviral-therapy
#15
Nicole E Behrens, Anne Wertheimer, Stephen A Klotz, Nafees Ahmad
Several studies have shown an increased accumulation of terminally differentiated T cells during HIV infection, suggestive of exhaustion/senescence, causing dysregulation of T cell homeostasis and function and rapid HIV disease progression. We have investigated whether long-term antiretroviral therapy (ART), which controls viremia and restores CD4 T cell counts, is correlated with reduction in terminally differentiated T cells, improved ratios of naïve to memory and function of T cells in 100 virologically controlled HIV-infected patients...
2018: PloS One
https://www.readbyqxmd.com/read/29895275/-late-for-testing-early-for-antiretroviral-therapy-less-likely-to-die-results-from-a-large-hiv-cohort-study-in-china-2006-2014
#16
Houlin Tang, Yurong Mao, Weiming Tang, Jing Han, Juan Xu, Jian Li
BACKGROUND: Timely HIV testing and initiation of antiretroviral therapy are two major determinants of survival for HIV-infected individuals. Our study aimed to explore the trend of late HIV/AIDS diagnoses and to assess the factors associated with these late diagnoses in China between 2006 and 2014. METHODS: We used data from the Chinese Comprehensive Response Information Management System of HIV/AIDS (CRIMS). All individuals who tested positive for HIV between 2006 and 2014 in China and were at least 15 years of age were included...
June 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29894408/long-term-topical-corticosteroid-use-and-risk-of-skin-cancer-a-systematic-review
#17
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
OBJECTIVE: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). INTRODUCTION: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29894382/transition-from-pediatric-to-adult-care-among-persons-with-perinatal-hiv-infection-in-new-york-city-2006-2015
#18
Qiang Xia, Bisrat Abraham, Dipal Shah, Chitra Ramaswamy, Sarah L Braunstein, Lucia V Torian
OBJECTIVE: To evaluate the transition process from pediatric to adult care among persons with perinatal HIV infection in New York City (NYC). DESIGN: A retrospective pre-post study and a matched exposed/unexposed nested cohort study. METHODS: Using data from the NYC HIV registry, a retrospective pre-post study was performed among persons who transitioned from pediatric to adult care to assess pre- and post-transition retention in care (≥1 CD4/viral load in a 12-month period), CD4 count, and viral suppression (≤200 copies/mL)...
June 11, 2018: AIDS
https://www.readbyqxmd.com/read/29893768/association-of-viral-suppression-with-lower-aids-defining-and-non-aids-defining-cancer-incidence-in-hiv-infected-veterans-a-prospective-cohort-study
#19
Lesley S Park, Janet P Tate, Keith Sigel, Sheldon T Brown, Kristina Crothers, Cynthia Gibert, Matthew Bidwell Goetz, David Rimland, Maria C Rodriguez-Barradas, Roger J Bedimo, Amy C Justice, Robert Dubrow
Background: Viral suppression is a primary marker of HIV treatment success. Persons with HIV are at increased risk for AIDS-defining cancer (ADC) and several types of non-AIDS-defining cancer (NADC), some of which are caused by oncogenic viruses. Objective: To determine whether viral suppression is associated with decreased cancer risk. Design: Prospective cohort. Setting: Department of Veterans Affairs. Participants: HIV-positive veterans (n = 42 441) and demographically matched uninfected veterans (n = 104 712) from 1999 to 2015...
June 12, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29893244/non-disclosed-men-who-have-sex-with-men-in-uk-hiv-transmission-networks-phylogenetic-analysis-of-surveillance-data
#20
Manon Ragonnet-Cronin, Stéphane Hué, Emma B Hodcroft, Anna Tostevin, David Dunn, Tracy Fawcett, Anton Pozniak, Alison E Brown, Valerie Delpech, Andrew J Leigh Brown
BACKGROUND: Patients who do not disclose their sexuality, including men who do not disclose same-sex behaviour, are difficult to characterise through traditional epidemiological approaches such as interviews. Using a recently developed method to detect large networks of viral sequences from time-resolved trees, we localised non-disclosed men who have sex with men (MSM) in UK transmission networks, gaining crucial insight into the behaviour of this group. METHODS: For this phylogenetic analysis, we obtained HIV pol sequences from the UK HIV Drug Resistance Database (UKRDB), a central repository for resistance tests done as part of routine clinical care throughout the UK...
June 2018: Lancet HIV
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