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HIV cohort study

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https://www.readbyqxmd.com/read/29683843/benefits-and-harms-of-lung-cancer-screening-in-hiv-infected-individuals-with-cd4-%C3%A2-500-a-simulation-study
#1
Chung Yin Kong, Keith Sigel, Steven D Criss, Deirdre F Sheehan, Matthew Triplette, Michael J Silverberg, Claudia I Henschke, Amy Justice, R Scott Braithwaite, Juan Wisnivesky, Kristina Crothers
OBJECTIVE: Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals. DESIGN: We modified an existing simulation model, the Lung Cancer Policy Model, for HIV-infected patients...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683841/monotypic-low-level-hiv-viremias-during-art-are-associated-with-disproportionate-production-of-x4-virions-and-systemic-immune-activation
#2
Marta E Bull, Caroline Mitchell, Jaime Soria, Sheila Styrchak, Corey Williams-Wietzikoski, Jillian Legard, Jennifer Mckernan-Mullin, Kelli Kraft, Frankline Onchiri, Joshua Stern, Sarah Holte, Kevin J Ryan, Edward P Acosta, Alberto La Rosa, Robert W Coombs, Eduardo Ticona, Lisa M Frenkel
OBJECTIVE: During effective antiretroviral therapy (ART), low-level plasma viremias (LLV) (HIV RNA >30-1000 copies/ml) can be detected intermittently. We hypothesized that systemic inflammation is associated with LLV either as the cause or result of the production of virions from clonally expanded cells. METHODS: Prospective cohort study of HIV-infected ART-naïve Peruvians enrolled prior to ART and followed for 2 years. Plasma HIV RNA and peripheral blood mononuclear cell (PBMC) HIV DNA concentrations were quantified pre-ART from individuals whose plasma HIV RNA was ART-suppressed...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683252/decreasing-rates-of-acute-myocardial-infarction-in-people-living-with-hiv-a-nationwide-cohort-study-in-spain-2004-2015
#3
M Masiá, S Padilla, J A García, J I Bernardino, A A Campins, V Asensi, F Gutiérrez
OBJECTIVES: Contemporary data from country-wide cohorts are needed to reveal trends in the occurrence of acute myocardial infarction (AMI) in people living with HIV (PLWH). We analysed time trends in the standardized incidence rate (sIR) of AMI in PLWH in Spain from 2004 to 2015, and compared them with trends in the general population. METHODS: A longitudinal study in a nationwide contemporary multicentre HIV-infected cohort was carried out. Data on all incident AMI events were collected, and age- and sex-standardized IRs calculated...
April 23, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29682399/retention-in-differentiated-care-multiple-measures-analysis-for-a-decentralized-hiv-care-and-treatment-program-in-north-central-nigeria
#4
Patricia A Agaba, Becky L Genberg, Atiene S Sagay, Oche O Agbaji, Seema T Meloni, Nancin Y Dadem, Grace O Kolawole, Prosper Okonkwo, Phyllis J Kanki, Norma C Ware
Objective: Differentiated care refers collectively to flexible service models designed to meet the differing needs of HIV-infected persons in resource-scarce settings. Decentralization is one such service model. Retention is a key indicator for monitoring the success of HIV treatment and care programs. We used multiple measures to compare retention in a cohort of patients receiving HIV care at "hub" (central) and "spoke" (decentralized) sites in a large public HIV treatment program in north central Nigeria...
2018: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/29682296/intensification-of-antiretroviral-treatment-with-raltegravir-for-pregnant-women-living-with-hiv-at-high-risk-of-vertical-transmission
#5
EDITORIAL
Thanyawee Puthanakit, Nattawan Thepnarong, Surasith Chaithongwongwatthana, Suvaporn Anugulruengkitt, Orawan Anunsittichai, Tuangtip Theerawit, Sasiwimol Ubolyam, Chitsanu Pancharoen, Praphan Phanuphak
Objectives:  The rate of vertical HIV transmission for women at high risk of HIV transmission stands at approximately 7.6%. In the present study we describe infant infection rates in women who had received raltegravir (RAL) intensification during pregnancy to a standard three-drug antiretroviral (ART) regimen in Thailand. Methods:  This prospective cohort study enrolled HIV-1-positive pregnant women at high risk of vertical transmission, as defined by (1) ART initiation at a gestational age (GA) ≥32 weeks or (2) HIV-1 RNA >1000 copies/mL at GA of 32-38 weeks while on ART...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681168/hiv-associated-cognitive-disorders-in-perinatally-infected-children-and-adolescents-a-novel-composite-cognitive-domains-score
#6
Nicole J Phillips, Jacqueline Hoare, Dan J Stein, Landon Myer, Heather J Zar, Kevin G F Thomas
Accurate assessment of HIV-associated cognitive disorders in perinatally infected children and adolescents is challenging. Assessments of general intellectual functioning, or global cognition, may not provide information regarding domain-specific strengths and weaknesses, and may therefore fail to detect, impaired trajectories of development within particular cognitive domains. We compare the efficacy of global cognitive scores to that of composite cognitive domain scores in detecting cognitive disorders in a sample of perinatally HIV-infected children, and a demographically matched HIV negative control group, drawn from the Cape Town Adolescent Antiretroviral Cohort (CTAAC) study...
April 22, 2018: AIDS Care
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#7
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29678963/correction-of-estimates-of-retention-in-care-among-a-cohort-of-hiv-positive-patients-in-uganda-in-the-period-before-starting-art-a-sampling-based-approach
#8
Patience Nyakato, Agnes N Kiragga, Andrew Kambugu, John Bradley, Kathy Baisley
OBJECTIVE: The aim of this study was to use a sampling-based approach to obtain estimates of retention in HIV care before initiation of antiretroviral treatment (ART), corrected for outcomes in patients who were lost according to clinic registers. DESIGN: Retrospective cohort study of HIV-positive individuals not yet eligible for ART (CD4 >500). SETTING: Three urban and three rural HIV care clinics in Uganda; information was extracted from the clinic registers for all patients who had registered for pre-ART care between January and August 2015...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678160/the-increasing-burden-and-complexity-of-multi-morbidity-and-polypharmacy-in-geriatric-hiv-patients-a-cross-sectional-study-of-people-aged-65-74-years-and-more-than-75-years
#9
G Guaraldi, A Malagoli, A Calcagno, C Mussi, B M Celesia, F Carli, S Piconi, G V De Socio, A M Cattelan, G Orofino, A Riva, E Focà, S Nozza, G Di Perri
BACKGROUND: Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to compare prevalence and risk factors of individual non-communicable diseases (NCD), multi-morbidity (MM) and polypharmacy (PP) amongst HIV positive and HIV negative controls at enrolment into the GEPPO cohort...
April 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29678121/the-relationship-between-adverse-neighborhood-socioeconomic-context-and-hiv-continuum-of-care-outcomes-in-a-diverse-hiv-clinic-cohort-in-the-southern-united-states
#10
Peter F Rebeiro, Chanelle J Howe, William B Rogers, Sally S Bebawy, Megan Turner, Asghar Kheshti, Catherine C McGowan, Stephen P Raffanti, Timothy R Sterling
Retention in care and viral suppression are critical to delaying HIV progression and reducing transmission. Neighborhood socioeconomic context (NSEC) may affect HIV care receipt. We therefore assessed NSEC's impact on retention and viral suppression in a diverse HIV clinical cohort. HIV-positive adults with ≥1 visit at the Vanderbilt Comprehensive Care Clinic and 5-digit ZIP code tabulation area (ZCTA) information between 2008 and 2012 contributed. NSEC z-score indices used neighborhood-level socioeconomic indicators for poverty, education, labor-force participation, proportion of males, median age, and proportion of residents of black race by ZCTA...
April 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29677628/circulating-metabolomic-profile-can-predict-dyslipidemia-in-hiv-patients-undergoing-antiretroviral-therapy
#11
Esther Rodríguez-Gallego, Josep Gómez, Pere Domingo, Sara Ferrando-Martínez, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Miguel López-Dupla, Raúl Beltrán-Debón, Verónica Alba, Montserrat Vargas, Alfonso J Castellano, Manuel Leal, Yolanda María Pacheco, Ezequiel Ruiz-Mateos, Félix Gutiérrez, Francesc Vidal, Anna Rull
BACKGROUND AND AIMS: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. METHODS: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months...
April 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29672699/less-severe-but-prolonged-course-of-acute-hepatitis-a-in-hiv-positive-patients-than-hiv-negative-patients-during-an-outbreak-a-multicenter-observational-study
#12
Yu-Lin Lee, Guan-Jhou Chen, Nan-Yu Chen, Bo-Huang Liou, Ning-Chi Wang, Yuan-Ti Lee, Chia-Jui Yang, Yu-Shan Huang, Hung-Jen Tang, Shie-Shian Huang, Yi-Chun Lin, Chien-Yu Cheng, Chen-Hsiang Lee, Tun-Chieh Chen, Ting-Shu Wu, Chun-Eng Liu, Po-Liang Lu, Chien-Ching Hung
Background: This multicenter retrospective cohort study aimed to compare the clinical presentations and evolution of acute hepatitis A (AHA) between HIV-positive patients and HIV-negative counterparts during the AHA outbreak. Methods: Information on demographics, clinical presentations, serial laboratory data, and abdominal imaging were collected from the medical records of the patients with AHA at the 14 designated hospitals for HIV care around Taiwan between May 2015 and May 2017...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29672628/derivation-and-internal-validation-of-a-mortality-risk-index-for-aged-people-living-with-hiv-the-dat-aids-score
#13
Maxime Hentzien, Cyrille Delpierre, Pascal Pugliese, Clotilde Allavena, Christine Jacomet, Marc-Antoine Valantin, André Cabié, Lise Cuzin, David Rey, Firouzé Bani-Sadr, Moustapha Dramé
OBJECTIVE: The objective was to develop a multivariable prognostic index for overall mortality over a five-year span integrating classical HIV biomarkers and comorbidities in people living with HIV (PLHIV) aged 60 or older. DESIGN: Prospective multicenter cohort study from the French Dat'AIDS cohort. METHODS: All HIV-1 infected patients aged 60 years or older on 1st January 2008 were included. Sociodemographic data, CD4 cell count, CD4 nadir, HIV viral load, history of comorbidities, hepatitis co-infections and laboratory parameters at baseline were considered as potential prognostic variables...
2018: PloS One
https://www.readbyqxmd.com/read/29672542/attrition-when-providing-antiretroviral-treatment-at-cd4-counts-500cells-%C3%AE-l-at-three-government-clinics-included-in-the-hptn-071-popart-trial-in-south-africa
#14
Peter Bock, Geoffrey Fatti, Nathan Ford, Karen Jennings, James Kruger, Colette Gunst, Françoise Louis, Nelis Grobbelaar, Kwame Shanaube, Sian Floyd, Ashraf Grimwood, Richard Hayes, Helen Ayles, Sarah Fidler, Nulda Beyers
INTRODUCTION: WHO recommends antiretroviral treatment (ART) for all HIV-positive individuals. This study evaluated the association between baseline CD4 count and attrition in a cohort of HIV positive adults initiating ART at three department of health (DOH) clinics routinely providing ART at baseline CD4 counts >500cells/μL for the HPTN 071 (PopART) trial. METHODS: All clients attending the DOH clinics were managed according to standard care guidelines with the exception that those starting ART outside of pertinent local guidelines signed research informed consent...
2018: PloS One
https://www.readbyqxmd.com/read/29670480/the-association-between-male-circumcision-and-condom-use-behavior-a-meta-analysis
#15
Steven Ndugwa Kabwama, Derrick Ssewanyana, Gabriele Berg-Beckhoff
Introduction: The protective benefit of male circumcision against spreading HIV is well established. Aim: The objective of this Meta-analysis was to investigate behavioral risk compensation measured as the change in condom use behavior in light of knowledge of the benefits of circumcision. Material and Methods: A systematic search was conducted from 6 bibliographic databases for studies that quantitatively assessed a link between male circumcision and condom use behavior...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29668748/mdr-tb-patients-in-kwazulu-natal-south-africa-cost-effectiveness-of-5-models-of-care
#16
Marian Loveday, Kristina Wallengren, Tarylee Reddy, Donela Besada, James C M Brust, Anna Voce, Harsha Desai, Jacqueline Ngozo, Zanele Radebe, Iqbal Master, Nesri Padayatchi, Emmanuelle Daviaud
BACKGROUND: South Africa has a high burden of MDR-TB, and to provide accessible treatment the government has introduced different models of care. We report the most cost-effective model after comparing cost per patient successfully treated across 5 models of care: centralized hospital, district hospitals (2), and community-based care through clinics or mobile injection teams. METHODS: In an observational study five cohorts were followed prospectively. The cost analysis adopted a provider perspective and economic cost per patient successfully treated was calculated based on country protocols and length of treatment per patient per model of care...
2018: PloS One
https://www.readbyqxmd.com/read/29668628/predictors-of-mortality-in-adults-on-treatment-for-human-immunodeficiency-virus-associated-tuberculosis-in-botswana-a-retrospective-cohort-study
#17
Ley Muyaya Muyaya, Taryn Young, Marian Loveday
Mortality in patients with human immunodeficiency virus (HIV)-associated tuberculosis (TB) is high, particularly in sub-Saharan Africa. This study aimed to compare mortality and predictors of mortality in those who were antiretroviral therapy (ART) naïve to those with prior ART exposure.This retrospective cohort study was conducted in Serowe/Palapye District, Botswana, a predominantly urban district with a large burden of HIV-associated TB with a high case fatality. Between January 1, 2013 and December 31, 2013, patients confirmed with HIV-associated TB were enrolled and followed up...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667531/is-tobacco-use-associated-with-neurocognitive-dysfunction-in-individuals-with-hiv
#18
Billy Tsima, Sarah Jane Ratcliffe, Robert Schnoll, Ian Frank, Dennis Larry Kolson, Robert Gross
INTRODUCTION: The prevalence of HIV-associated neurocognitive disorders continues to rise despite the widespread use of antiretroviral therapy. We aimed to define the risk of neurocognitive dysfunction among smokers relative to nonsmokers. METHODS: We conducted a retrospective cohort study including HIV-infected adults ages 21 to 65 years. The Mental Alternation Test (MAT) was the primary outcome. The odds of cognitive impairment were compared using random-effects logistic regression to adjust for potential confounders...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#19
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29666966/point-of-care-lung-ultrasound-for-diagnosis-of-pneumocystis-jirovecii-pneumonia-notes-from-the-field
#20
Maria Teresa Giordani, Francesca Tamarozzi, Daniel Kaminstein, Enrico Brunetti, Tom Heller
BACKGROUND: Thoracic ultrasound is helpful to evaluate lung pathology in patients with acute dyspnea. Several studies have demonstrated the efficacy of point-of-care ultrasound in patients with extrapulmonary TB and HIV co-infection. This retrospective, open-label case-control study explores the role of lung ultrasound in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV-positive patients. In particular, it highlights the potential role of specific sonographic features that may be unique to this population...
April 17, 2018: Critical Ultrasound Journal
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