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https://www.readbyqxmd.com/read/27936236/an-evaluation-of-selected-populations-for-hiv-1-vaccine-cohort-development-in-nigeria
#1
Ogbonnaya S Njoku, Mark M Manak, Robert J O'Connell, Ashley L W Shutt, Jennifer A Malia, Richard A Heipertz, Sodsai Tovanabutra, Mark J Milazzo, Gideon Akindiran Akintunde, Abraham S Alabi, Aminu Suleiman, Amos A Ogundeji, Terfa S Kene, Robbie Nelson, Ojor R Ayemoba, Darrell E Singer, Merlin L Robb, Sheila A Peel, Nelson L Michael
Development of a globally effective HIV-1 vaccine will need to encompass Nigeria, one of the hardest hit areas, with an estimated 3.2 million people living with HIV. This cross-sectional Institutional Review Board (IRB) approved study was conducted in 2009-12 at four market sites and two highway settlements sites in Nigeria to identify and characterize populations at high risk for HIV; engage support of local stakeholders; and assess the level of interest in future vaccine studies. Demographic, HIV risk data were collected by structured interviewer-administered questionnaires...
2016: PloS One
https://www.readbyqxmd.com/read/27936146/performance-of-clinical-screening-algorithms-for-tuberculosis-intensified-case-finding-among-people-living-with-hiv-in-western-kenya
#2
Surbhi Modi, Joseph S Cavanaugh, Ray W Shiraishi, Heather L Alexander, Kimberly D McCarthy, Barbara Burmen, Hellen Muttai, Chad M Heilig, Allyn K Nakashima, Kevin P Cain
OBJECTIVE: To assess the performance of symptom-based screening for tuberculosis (TB), alone and with chest radiography among people living with HIV (PLHIV), including pregnant women, in Western Kenya. DESIGN: Prospective cohort study. METHODS: PLHIV from 15 randomly-selected HIV clinics were screened with three clinical algorithms [World Health Organization (WHO), Ministry of Health (MOH), and "Improving Diagnosis of TB in HIV-infected persons" (ID-TB/HIV) study], underwent chest radiography (unless pregnant), and provided two or more sputum specimens for smear microscopy, liquid culture, and Xpert MTB/RIF...
2016: PloS One
https://www.readbyqxmd.com/read/27936092/the-association-between-sexually-transmitted-infections-length-of-service-and-other-demographic-factors-in-the-u-s-military
#3
Robert Deiss, Richard J Bower, Edgie Co, Octavio Mesner, Jose L Sanchez, Jennifer Masel, Anuradha Ganesan, Grace E Macalino, Brian K Agan
BACKGROUND: Numerous studies have found higher rates of sexually transmitted infections (STIs) among military personnel than the general population, but the cumulative risk of acquiring STIs throughout an individual's military career has not been described. METHODS: Using ICD-9 diagnosis codes, we analyzed the medical records of 100,005 individuals from all service branches, divided in equal cohorts (n = 6,667) between 1997 and 2011. As women receive frequent STI screening compared to men, these groups were analyzed separately...
2016: PloS One
https://www.readbyqxmd.com/read/27935535/continuous-ambulatory-peritoneal-dialysis-in-patients-with-hiv-and-end-stage-renal-failure
#4
Kwazi C Ndlovu, Alain Assounga
♦ Background: This study aimed to evaluate the differences in continuous ambulatory peritoneal dialysis (CAPD)-related outcomes according to human immunodeficiency virus (HIV) status of end-stage renal failure patients. ♦ Methods: This prospective cohort study included 70 HIV-negative and 70 HIV-positive consecutive patients with renal failure who underwent dialysis with newly inserted Tenckhoff catheters between September 2012 and February 2015. Patients were followed up monthly at a central renal clinic for 1 year or until the primary endpoints of technique failure or death...
December 1, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27935534/representativeness-of-honeypot-trial-participants-to-australasian-pd-patients
#5
Lei Zhang, Sunil V Badve, Elaine M Pascoe, Elaine Beller, Alan Cass, Carolyn Clark, Janak de Zoysa, Nicole M Isbel, Xusheng Liu, Steven McTaggart, Alicia T Morrish, Geoffrey Playford, Anish Scaria, Paul Snelling, Liza A Vergara, Carmel M Hawley, David W Johnson
♦ Background: This study aimed to evaluate the differences in continuous ambulatory peritoneal dialysis (CAPD)-related outcomes according to human immunodeficiency virus (HIV) status of end-stage renal failure patients. ♦ Methods: This prospective cohort study included 70 HIV-negative and 70 HIV-positive consecutive patients with renal failure who underwent dialysis with newly inserted Tenckhoff catheters between September 2012 and February 2015. Patients were followed up monthly at a central renal clinic for 1 year or until the primary endpoints of technique failure or death...
December 1, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27931519/high-prevalence-of-hiv-chlamydia-and-gonorrhoea-among-men-who-have-sex-with-men-and-transgender-women-attending-trusted-community-centres-in-abuja-and-lagos-nigeria
#6
Babajide Keshinro, Trevor A Crowell, Rebecca G Nowak, Sylvia Adebajo, Sheila Peel, Charlotte A Gaydos, Cristina Rodriguez-Hart, Stefan D Baral, Melissa J Walsh, Ogbonnaya S Njoku, Sunday Odeyemi, Teclaire Ngo-Ndomb, William A Blattner, Merlin L Robb, Manhattan E Charurat, Julie Ake
INTRODUCTION: Sexually transmitted infection (STI) and HIV prevalence have been reported to be higher amongst men who have sex with men (MSM) in Nigeria than in the general population. The objective of this study was to characterize the prevalence of HIV, chlamydia and gonorrhoea in this population using laboratory-based universal testing. METHODS: TRUST/RV368 represents a cohort of MSM and transgender women (TGW) recruited at trusted community centres in Abuja and Lagos, Nigeria, using respondent-driven sampling (RDS)...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27931339/mobility-patterns-of-persons-at-risk-for-drug-resistant-tuberculosis-in-mumbai-india
#7
E Conners, R S Garfein, T C Rodwell, Z F Udwadia, D G Catanzaro
SETTING: Tuberculosis (TB) hospital in Mumbai, India. OBJECTIVE: To describe the mobility patterns of persons with suspected drug-resistant tuberculosis (DR-TB) and to assess whether there were significant differences in demographic or risk characteristics based on mobility. DESIGN: Observational cohort study of TB clinic patients at risk for DR-TB. RESULTS: Among 602 participants, 37% had ever moved from their place of birth; 14% were local movers (within state), and 23% were distant movers, between states or countries...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931335/clinical-characteristics-and-outcomes-of-tuberculosis-in-douala-cameroon-a-7-year-retrospective-cohort-study
#8
B H Mbatchou Ngahane, F Dahirou, C Tchieche, A Wandji, C Ngni, A Nana-Metchedjin, E Nyankiy, M L Endale Mangamba, C Kuaban
SETTING: Tuberculosis (TB) clinic, Douala Laquintinie Hospital, Douala, Cameroon. OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes. DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes. RESULTS: Of 8902 TB cases included, 5110 (57...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27930613/project-shikamana-baseline-findings-from-a-community-empowerment-based-combination-hiv-prevention-trial-among-female-sex-workers-in-iringa-tanzania
#9
Deanna Kerrigan, Jessie Mbwambo, Samuel Likindikoki, Sarah Beckham, Ard Mwampashi, Catherine Shembilu, Andrea Mantsios, Anna Leddy, Wendy Davis, Noya Galai
BACKGROUND: Community empowerment approaches have been found to be effective in responding to HIV among female sex workers (FSWs) in South Asia and Latin America. To date, limited rigorous evaluations of these approaches have been conducted in sub-Saharan Africa. METHODS: A phase II community randomized controlled trial is being conducted in Iringa, Tanzania, to evaluate the effectiveness of a community empowerment-based combination HIV prevention model (Project Shikamana) among a stratified sample of HIV-infected and HIV-uninfected FSWs...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930612/potential-impact-of-integrated-stigma-mitigation-interventions-in-improving-hiv-aids-service-delivery-and-uptake-for-key-populations-in-senegal
#10
Carrie E Lyons, Sosthenes Ketende, Daouda Diouf, Fatou M Drame, Benjamin Liestman, Karleen Coly, Cheikh Ndour, Gnilane Turpin, Souleymane Mboup, Karim Diop, Coumba Toure-Kane, Delivette Castor, Nafissatou Leye-Diouf, Stefan Baral
BACKGROUND: Men who have sex with men (MSM) and female sex workers (FSW) are consistently shown to have a higher burden of HIV compared with other adults in Senegal. This study, HIV Prevention 2.0, evaluates the impact of the 3-tiered integrated stigma mitigation interventions (ISMIs) approach to optimizing HIV service delivery for key populations in Senegal. METHODS: Baseline assessment includes a questionnaire and biological testing for HIV. A proportion of participants enrolled into a 24-month longitudinal cohort with questionnaires and biological testing every 3 months...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930403/has-the-phasing-out-of-stavudine-in-accordance-with-changes-in-who-guidelines-led-to-a-decrease-in-single-drug-substitutions-in-first-line-antiretroviral-therapy-for-hiv-in-sub-saharan-africa
#11
Alana T Brennan, Mary-Ann Davies, Jacob Bor, Gilles Wandeler, Kathryn Stinson, Robin Wood, Hans Prozesky, Frank Tanser, Geoffrey Fatti, Andrew Boulle, Izukanji Sikazwe, Kara Wools-Kaloustian, Constantin Yiannoutsos, Valériane Leroy, Nathalie de Rekeneire, Matthew P Fox
OBJECTIVE: We assessed the relationship between phasing out stavudine in first-line antiretroviral therapy (ART) in accordance with WHO 2010 policy and single-drug substitutions (SDS) (substituting the nucleoside reverse transcriptase inhibitor in first-line ART) in sub-Saharan Africa. DESIGN: Prospective cohort analysis (International epidemiological Databases to Evaluate AIDS-Multiregional) including ART-naive, HIV-infected patients aged at least 16 years, initiating ART between January 2005 and December 2012...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27927871/severity-of-respiratory-syncytial-virus-lower-respiratory-tract-infection-with-viral-coinfection-in-hiv-uninfected-children
#12
Natalie I Mazur, Louis Bont, Adam L Cohen, Cheryl Cohen, Anne von Gottberg, Michelle J Groome, Orienka Hellferscee, Kerstin Klipstein-Grobusch, Omphile Tschegofatso Mekgoe, Fathima Naby, Jocelyn Moyes, Stefano Tempia, Florette K Treurnicht, Marietje Venter, Sibongile Walaza, Nicole Wolter, Shabir A Madhi
BACKGROUND: Molecular diagnostics enable sensitive detection of respiratory viruses but their clinical significance remains unclear in pediatric lower respiratory tract infections (LRTI). We aimed to determine whether viral coinfections increased life-threatening disease in a large cohort. METHODS: Molecular testing was performed for respiratory viruses in nasopharyngeal aspirates collected from children aged <5 years within 24 hours of hospital admission during sentinel surveillance for Severe Acute Respiratory Illness (SARI) hospitalisation conducted in South Africa during February 2009-December 2013...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927863/longitudinal-viral-dynamics-in-semen-during-early-hiv-infection
#13
Sheldon R Morris, Mitchell Zhao, Davey R Smith, Milenka V Vargas, Susan J Little, Sara Gianella
BACKGROUND: Multiple viruses co-infect the male genital tract, influencing each other's replication and perhaps affecting HIV pathogenesis and disease progression. METHODS: This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San Diego Primary Infection Cohort and 67 seminal samples from HIV-negative healthy controls. Seminal HIV RNA and DNA from seven human herpesviruses (HHV) were measured by RT-PCR. Longitudinal shedding rates were determined by Kaplan-Meier survival analysis...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927856/the-long-term-mortality-of-tuberculosis-meningitis-patients-in-new-york-city-a-cohort-study
#14
Christopher Vinnard, Liza King, Sonal Munsiff, Aldo Crossa, Kentaro Iwata, Jotam Pasipanodya, Douglas Proops, Shama Ahuja
BACKGROUND: Tuberculosis meningitis (TBM) is the most devastating clinical presentation of infection with M. tuberculosis; delayed initiation of effective anti-tuberculosis (TB) therapy is associated with poor treatment outcomes. Our objective was to determine the relationship between drug resistance and 10-year mortality among TBM patients. METHODS: We conducted a retrospective cohort study of 324 patients with culture-confirmed TBM, susceptibility results reported for isoniazid and rifampin, and initiation of at least two anti-TB drugs, reported to the TB registry in New York City, NY (US) between January 1, 1992 and December 31, 2001...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927852/frequency-of-viremic-episodes-in-hiv-infected-women-initiating-antiretroviral-therapy-during-pregnancy-a-cohort-study
#15
Landon Myer, Lorna Dunning, Maia Lesosky, Nei-Yuan Hsiao, Tamsin Phillips, Greg Petro, Allison Zerbe, James A McIntyre, Elaine J Abrams
BACKGROUND: The numbers of HIV-infected women initiating antiretroviral therapy (ART) in pregnancy are increasing rapidly with global policy changes. There are widespread concerns about ART adherence during pregnancy and postpartum but few data on viral suppression (VS) over time in these populations. METHODS: We followed a cohort of 523 women in Cape Town, South Africa initiating ART in pregnancy (once daily tenofovir 300mg, emtracitabine 200mg and efavirenz 600mg) and achieving VS (<50 copies/mL)...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927190/cd4-cell-counts-and-presence-of-aids-in-hiv-positive-patients-entering-specialized-care-a-comparison-of-migrant-groups-in-the-german-clinsurv-hiv-cohort-study-1999-2013
#16
Nadine Zeitlmann, Barbara Gunsenheimer-Bartmeyer, Claudia Santos-Hövener, Christian Kollan, Matthias An der Heiden
BACKGROUND: Although early presentation to HIV-care is essential to ensure timely initiation of antiretroviral therapy, recent studies have shown that especially migrants present to HIV-care at a later stage of HIV-infection. Currently, thirty percent of all newly diagnosed HIV cases in Germany originate from abroad. So far it is unknown, which specific migrant groups in Germany are particularly at risk for late presentation to HIV-care. METHODS: We used data from the Clinical Surveillance of HIV Disease (ClinSurv) cohort, a multi-centre observational cohort (01/01/1999 and 31/07/2013) and included treatment-naïve patients with valid information on country of origin and date of enrolment...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27926762/association-of-arterial-and-lymph-node-inflammation-with-distinct-inflammatory-pathways-in-human-immunodeficiency-virus-infection
#17
Ahmed Tawakol, Amorina Ishai, Danny Li, Richard A P Takx, Sophia Hur, Yannick Kaiser, Miguel Pampaloni, Adam Rupert, Denise Hsu, Irini Sereti, Rémi Fromentin, Nicolas Chomont, Peter Ganz, Steven G Deeks, Priscilla Y Hsue
Importance: Human immunodeficiency virus (HIV) infection is associated with a high risk of cardiovascular disease and increased arterial inflammation. In HIV, inflammation is also increased within lymph nodes (LNs), tissues known to harbor the virus even among treated and suppressed individuals. Objective: To test the hypothesis that arterial inflammation is linked to HIV disease activity and to inflammation within HIV-infected tissues (LNs). Design, Setting, and Participants: For this case-control study, participants were recruited from the SCOPE (Observational Study of the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of individuals receiving care at San Francisco General Hospital and the San Francisco Veteran's Affairs Medical Center...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27925609/a-comparison-of-virological-suppression-and-rebound-between-indigenous-and-non-indigenous-persons-initiating-combination-antiretroviral-therapy-in-a-multisite-cohort-of-individuals-living-with-hiv-in-canada
#18
Anita C Benoit, Jaime Younger, Kerrigan Beaver, Randy Jackson, Mona Loutfy, Renée Masching, Tony Nobis, Earl Nowgesic, Doe O'Brien-Teengs, Wanda Whitebird, Art Zoccole, Mark Hull, Denise Jaworsky, Anita Rachlis, Sean Rourke, Ann N Burchell, Curtis Cooper, Robert Hogg, Marina B Klein, Nima Machouf, Julio Montaner, Chris Tsoukas, Janet Raboud, Building Bridges
BACKGROUND: This study compared time to virologic suppression and rebound between Indigenous and non-Indigenous individuals living with HIV in Canada initiating combination antiretroviral therapy (cART). METHODS: Data were from the Canadian Observational Cohort collaboration; 8 studies of treatment-naïve persons with HIV initiating cART after 1/1/2000. Fine and Gray models were used to estimate the effect of ethnicity on 1) time to virologic suppression (two consecutive viral loads (VLs) <50 copies/mL at least three months apart) after adjusting for the competing risk of death and 2) time until virologic rebound (two consecutive VLs >200 copies/mL at least three months apart) following suppression...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27925484/risk-factors-associated-with-repeated-hiv-testing-among-internet-using-men-who-have-sex-with-men
#19
Brent A Johnson, Jennie McKenney, Alexandra V Ricca, Eli S Rosenberg, Chang Liu, Akshay Sharma, Patrick S Sullivan
: Men who have sex with men (MSM) represent a disproportionately impacted risk group for HIV incidence among at-risk U.S. POPULATIONS: Few studies have identified risk factors associated with HIV testing frequency both within and outside of traditional health care settings. MSM enrolled in a prospective cohort were mailed at-home specimen collection kits and followed for a year. Incidence density rate ratios (IDRR) of testing were calculated, and generalized estimating equations were used to analyze the association between HIV testing and behavioral factors...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925409/more-improvement-than-progression-of-liver-fibrosis-following-antiretroviral-therapy-in-a-longitudinal-cohort-of-hiv-infected-patients-with-or-without-hbv-and-hcv-co-infections
#20
Yingying Ding, Song Duan, Runhua Ye, Yuecheng Yang, Shitang Yao, Jibao Wang, Dongdong Cao, Xing Liu, Lin Lu, Manhong Jia, Zunyou Wu, Na He
We examined the effect of combination antiretroviral therapy (cART) on liver fibrosis among HIV-infected patients with or without Hepatitis B (HBV) or C virus (HCV) co-infection. This was a retrospective cohort study of HIV-infected patients receiving cART during 2004-2016. Liver fibrosis was assessed using Fibrosis-4 (FIB-4) score with 3 classifications: Class 1, < 1.45; Class 2, 1.45-3.25; Class 3, > 3.25. Of 3,900 participants, 68.6% were HIV mono-infected, 5.3% were HIV/HBV co-infected, 23.8% were HIV/HCV co-infected and 2...
December 7, 2016: Journal of Viral Hepatitis
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