Andrea Da Porto, Debora Donnini, Fabio Vanin, Arianna Romanin, Martina Antonello, Paolo Toritto, Eleonora Varisco, Gabriele Brosolo, Cristiana Catena, Leonardo A Sechi, Giorgio Soardo
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver condition with significant risk of progression to steatohepatitis and cirrhosis. Therapeutic strategies in NAFLD include lifestyle changes mainly related to dietary interventions and use of drugs or nutritional components that could improve plasma lipid profiles and insulin sensitivity and decrease the local inflammatory response. In this study, we tested the effects of monacolin K, an inhibitor of HMCoA reductase. In a prospective, uncontrolled, open study, we treated 24 patients with NAFLD and mild hypercholesterolemia with 10 mg/day of monacolin K...
April 14, 2023: Nutrients