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https://www.readbyqxmd.com/read/29346028/biophysics-model-of-heavy-ion-degradation-of-neuron-morphology-in-mouse-hippocampal-granular-cell-layer-neurons
#1
Murat Alp, Francis A Cucinotta
Exposure to heavy-ion radiation during cancer treatment or space travel may cause cognitive detriments that have been associated with changes in neuron morphology and plasticity. Observations in mice of reduced neuronal dendritic complexity have revealed a dependence on radiation quality and absorbed dose, suggesting that microscopic energy deposition plays an important role. In this work we used morphological data for mouse dentate granular cell layer (GCL) neurons and a stochastic model of particle track structure and microscopic energy deposition (ED) to develop a predictive model of high-charge and energy (HZE) particle-induced morphological changes to the complex structures of dendritic arbors...
January 18, 2018: Radiation Research
https://www.readbyqxmd.com/read/29310707/development-of-ahmite1-markers-through-genome-wide-analysis-in-peanut-arachis-hypogaea-l
#2
M Gayathri, Kenta Shirasawa, R K Varshney, M K Pandey, R S Bhat
OBJECTIVE: In peanut, the DNA polymorphism is very low despite enormous phenotypic variations. This limits the use of genomics-assisted breeding to enhance peanut productivity. This study aimed to develop and validate new AhMITE1 and cleaved amplified polymorphic sequences (CAPS) markers. RESULTS: In total, 2957 new AhMITE1 markers were developed in addition to identifying 465 already reported markers from the whole genome re-sequencing data (WGRS) of 33 diverse genotypes of peanut...
January 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29289559/geographical-distribution-and-species-identification-of-human-filariasis-and-onchocerciasis-in-bioko-island-equatorial-guinea
#3
Thuy-Huong Ta, Laura Moya, Justino Nguema, Pilar Aparicio, María Miguel Oteo, Gema Cenzual, Isabel Canorea, Marta Lanza, Agustín Benito, James Lee Crainey, José Miguel Rubio
Human filariae are vector-borne parasites and the causative agents of various diseases, including human onchocerciasis and lymphatic filariasis. Onchocerciasis causes a spectrum of cutaneous and ophthalmologic manifestations (including blindness) and has long been a major public health problem in Bioko Island (Equatorial Guinea). Bioko Island has been included in the WHO's Onchocerciasis Control Program since 1987. In Bioko Island, the specificity and sensitivity of clinical Onchocerca volvulus diagnosis is key...
December 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29275076/dermatological-manifestations-in-onchocerciasis-a-retrospective-study-of-400-imported-cases
#4
Sabino Puente, German Ramirez-Olivencia, Mar Lago, Mercedes Subirats, Eugenio Perez-Blazquez, Fernando Bru, Teresa Garate, Belén Vicente, Moncef Belhassen-Garcia, Antonio Muro
INTRODUCTION: Onchocerciasis is caused by Onchocerca volvulus and mainly leads to pruritus and skin and visual disorders, including blindness. Seventeen million people are infected in 38 countries; 31 of these are in sub-Saharan Africa, six in Latin America and one on the Arabian Peninsula. More than 99% of cases occur in sub-Saharan Africa where 120 million people are at risk of infection. Eye disorders have been well-documented; however, skin disorders have not been described accurately...
December 20, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29194104/comparison-of-outcomes-of-3-snip-punctoplasty-versus-simple-punctal-dilatation-with-monocanalicular-intubation-for-acquired-punctal-stenosis
#5
Swati Singh, Mohammad Javed Ali, Ashik Mohamed
PURPOSE: To evaluate and compare the outcomes of invasive (rectangular 3-snip punctoplasty) versus minimally invasive (punctal dilatation with monocanalicular intubation) treatment modalities for the management of acquired punctal stenosis. METHODS: A retrospective, comparative, interventional case series was performed on 60 eyes of 36 patients with acquired punctal stenosis. Patients were categorized in 2 groups based on the intervention as 3-snip punctoplasty (group A) and punctal dilatation with monocanalicular intubation (group B)...
November 15, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29185236/an-automated-system-combining-safety-signal-detection-and-prioritization-from-healthcare-databases-a-pilot-study
#6
Mickael Arnaud, Bernard Bégaud, Frantz Thiessard, Quentin Jarrion, Julien Bezin, Antoine Pariente, Francesco Salvo
INTRODUCTION: Signal detection from healthcare databases is possible, but is not yet used for routine surveillance of drug safety. One challenge is to develop methods for selecting signals that should be assessed with priority. AIM: The aim of this study was to develop an automated system combining safety signal detection and prioritization from healthcare databases and applicable to drugs used in chronic diseases. METHODS: Patients present in the French EGB healthcare database for at least 1 year between 2005 and 2015 were considered...
November 28, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29162988/suture-assisted-punctoplasty
#7
Amun Sachdev, Suresh R Sagili
Purpose: To describe a surgical technique in which a suture, instead of forceps, is used to improve access for the introduction of scissors and more easily achieve an appropriately-sized punctoplasty. Materials and Methods: In this technique, a new modification of the 2-snip punctoplasty, a 6-0 polyglactin 910 suture is passed through the posterior wall of the punctum to apply traction. A video of the technique is provided. Results: This technique improves the surgical field of view and eases access for introduction of Vannas scissors into the punctum to perform the punctoplasty...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/29138647/nodding-syndrome-ns-and-onchocerca-volvulus-ov-in-northern-uganda
#8
David Kitara Lagoro, Denis Anywar Arony
Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. There are recent published information suggesting associations between Nodding Syndrome (NS) with cerebrospinal fluid (CSF) VGKC antibodies and serum leiomidin-1 antibody cross reacting with Onchocerca Volvulus (OV). These findings suggest a neuro-inflammatory cause of NS and they are important findings in the search for the cause of Nodding Syndrome...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29093790/perioperative-evaluation-of-respiratory-muscle-strength-after-scoliosis-correction-in-patients-with-duchenne-muscular-dystrophy
#9
Wataru Saito, Kosuke Mizuno, Gen Inoue, Takayuki Imura, Toshiyuki Nakazawa, Masayuki Miyagi, Eiki Shirasawa, Kentaro Uchida, Masashi Takaso
Study Design: Retrospective cohort study. Purpose: To investigate the effect of spinal correction on respiratory muscle strength in patients with Duchenne muscular dystrophy (DMD). Overview of Literature: Several studies have reported that scoliosis correction in patients with DMD does not improve pulmonary function. In these studies, pulmonary function was evaluated using the traditional spirometric values of percent vital capacity (%VC) and percent forced vital capacity (%FVC)...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29064472/genome-wide-association-studies-of-smooth-pursuit-and-antisaccade-eye-movements-in-psychotic-disorders-findings-from-the-b-snip-study
#10
R Lencer, L J Mills, N Alliey-Rodriguez, R Shafee, A M Lee, J L Reilly, A Sprenger, J E McDowell, S A McCarroll, M S Keshavan, G D Pearlson, C A Tamminga, B A Clementz, E S Gershon, J A Sweeney, J R Bishop
Eye movement deviations, particularly deficits of initial sensorimotor processing and sustained pursuit maintenance, and antisaccade inhibition errors, are established intermediate phenotypes for psychotic disorders. We here studied eye movement measures of 849 participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study (schizophrenia N=230, schizoaffective disorder N=155, psychotic bipolar disorder N=206 and healthy controls N=258) as quantitative phenotypes in relation to genetic data, while controlling for genetically derived ancestry measures, age and sex...
October 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28994268/classification-of-lacrimal-punctal-stenosis-and-its-related-histopathological-feature-in-patients-with-epiphora
#11
Mun Chong Hur, Sang Wook Jin, Mi Sook Roh, Woo Jin Jeong, Won Yeol Ryu, Yoon Hyung Kwon, Hee Bae Ahn
PURPOSE: To evaluate the classification of punctal stenosis based on the shape of the external punctum, clinical characteristics and histopathologic features. METHODS: Patients who experienced tearing and were diagnosed with punctal stenosis were evaluated in this study. Punctal stenosis was classified according to the shape of the lower external punctum, which included membranous type, slit type, horseshoe type, and pinpoint type. Tear meniscus height, 2% fluorescein dye disappearance test and lacrimal pathway irrigation were measured or performed...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28972982/feasibility-of-utilizing-the-sd-bioline-onchocerciasis-igg4-rapid-test-in-onchocerciasis-surveillance-in-senegal
#12
Yakou Dieye, Helen L Storey, Kelsey L Barrett, Emily Gerth-Guyette, Laura Di Giorgio, Allison Golden, Dunia Faulx, Michael Kalnoky, Marie Khemesse Ngom Ndiaye, Ngayo Sy, Malang Mané, Babacar Faye, Mamadou Sarr, Elhadji Mamadou Dioukhane, Roger B Peck, Philippe Guinot, Tala de Los Santos
As effective onchocerciasis control efforts in Africa transition to elimination efforts, different diagnostic tools are required to support country programs. Senegal, with its long standing, successful control program, is transitioning to using the SD BIOLINE Onchocerciasis IgG4 (Ov16) rapid test over traditional skin snip microscopy. The aim of this study is to demonstrate the feasibility of integrating the Ov16 rapid test into onchocerciasis surveillance activities in Senegal, based on the following attributes of acceptability, usability, and cost...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28969662/o-5s-quantitative-real-time-pcr-a-new-diagnostic-tool-for-laboratory-confirmation-of-human-onchocerciasis
#13
Solomon A Mekonnen, Marcus Beissner, Malkin Saar, Solomon Ali, Ahmed Zeynudin, Kassahun Tesfaye, Mulatu G Adbaru, Florian Battke, Sven Poppert, Michael Hoelscher, Thomas Löscher, Gisela Bretzel, Karl-Heinz Herbinger
BACKGROUND: Onchocerciasis is a parasitic disease caused by the filarial nematode Onchocerca volvulus. In endemic areas, the diagnosis is commonly confirmed by microscopic examination of skin snip samples, though this technique is considered to have low sensitivity. The available melting-curve based quantitative real-time PCR (qPCR) using degenerated primers targeting the O-150 repeat of O. volvulus was considered insufficient for confirming the individual diagnosis, especially in elimination studies...
October 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28809073/biocatalytic-stimuli-responsive-asymmetric-triblock-terpolymer-membranes-for-localized-permeability-gating
#14
Jennifer L Poole, Scott Donahue, David Wilson, Yuk Mun Li, Qi Zhang, Yibei Gu, Rachel Ferebee, Zhao Lu, Rachel Mika Dorin, Lawrence F Hancock, Larry Takiff, Ilhem F Hakem, Michael R Bockstaller, Ulrich Wiesner, Jeremy Walker
The functionalization with phosphotriesterase of poly(isoprene-b-styrene-b-4-vinylpyridine)-based nanoporous membranes fabricated by self-assembly and nonsolvent induced phase separation (SNIPS) is shown to enable dynamically responsive membranes capable of substrate-specific and localized gating response. Integration of the SNIPS process with macroporous nylon support layers yields mechanically robust textile-type films with high moisture vapor transport rates that display rapid and local order-of-magnitude modulation of permeability...
October 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28774318/important-progress-towards-elimination-of-onchocerciasis-in-the-west-region-of-cameroon
#15
Guy-Roger Kamga, Fanny N Dissak-Delon, Hugues C Nana-Djeunga, Benjamin D Biholong, Stephen Mbigha Ghogomu, Jacob Souopgui, Joseph Kamgno, Annie Robert
BACKGROUND: After more than a decade of community-directed treatment with ivermectin (CDTI) in the West Region of Cameroon, epidemiological evaluation conducted in 2011 showed that onchocerciasis endemicity was still high in some communities. The conceptual framework for onchocerciasis elimination recommends in such case, to conduct additional phase 1A surveys at intervals of three to four years. Therefore, to assess the progress made towards the elimination of onchocerciasis in the West CDTI projects, we conducted a cross-sectional survey in May 2015 in 15 unevaluated communities where the highest baseline endemicity level were found in 1996...
August 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28743265/the-predictive-value-of-respiratory-function-tests-for-non-invasive-ventilation-in-amyotrophic-lateral-sclerosis
#16
T B M Tilanus, J T Groothuis, J M C TenBroek-Pastoor, T B Feuth, Y F Heijdra, J P L Slenders, J Doorduin, B G Van Engelen, M J Kampelmacher, J Raaphorst
BACKGROUND: Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respiratory function tests, has shown room for improvement. It is currently unknown which respiratory function test predicts an appropriate timing of the initiation of NIV. METHODS: We analysed, retrospectively, serial data of five respiratory function tests: forced vital capacity (FVC), peak cough flow (PCF), maximum inspiratory and expiratory pressure (MIP and MEP) and sniff nasal inspiratory pressure (SNIP) in patients with ALS...
July 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28728441/ability-of-pulmonary-function-decline-to-predict-death-in-amyotrophic-lateral-sclerosis-patients
#17
Irina Enache, Cristina Pistea, Marie Fleury, Mickael Schaeffer, Monique Oswald-Mammosser, Andoni Echaniz-Laguna, Christine Tranchant, Nicolas Meyer, Anne Charloux
OBJECTIVES: Objectives were to evaluate the relative risk of death associated with lung function decline in patients with amyotrophic lateral sclerosis (ALS), and to examine the ability of ALS patients to perform volitional pulmonary function tests (PFTs). METHODS: The PFTs of 256 consecutive patients referred to the Strasbourg University Hospital ALS Centre over an eight-year period were reviewed. Slow vital capacity (VC), maximal inspiratory and expiratory pressures (MIP, MEP), sniff nasal inspiratory pressure (SNIP), and peak cough flow (PCF) were performed at diagnosis and then every four months...
July 20, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28722619/evaluation-of-onchocerciasis-transmission-in-tanzania-preliminary-rapid-field-results-in-the-tukuyu-focus-2015
#18
Heather N Paulin, Andreas Nshala, Akili Kalinga, Upendo Mwingira, Ryan Wiegand, Vitaliano Cama, Paul T Cantey
To compare diagnostic tests for onchocerciasis in a setting that has suppressed transmission, a randomized, age-stratified study was implemented in an area in Tanzania that had received 15 rounds of annual mass drug administration (MDA) with ivermectin. Study participants (N = 948) from 11 villages underwent a questionnaire, skin examination, skin snips, and blood draw. The burden of symptomatic disease was low. Ov-16 antibody rapid diagnostic test (RDT) results were positive in 38 (5.5%) participants, with 1 (0...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28670211/trend-analysis-of-journal-metrics-a-new-academic-library-service
#19
Peter Kokol
OBJECTIVE: Temporal trends in source normalized impact per paper (SNIP) values for the three top-ranking nursing journals were analyzed and compared to explore whether predicting future SNIP values based on trend analysis could be an innovative service provided by librarians. METHODS: The International Journal of Nursing Studies, Journal of Nursing Scholarship, and Journal of Advanced Nursing were the three top-ranked nursing journals according to 2015 SNIP values...
July 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28667981/full-area-covered-3d-profile-measurement-of-special-shaped-optics-based-on-a-new-prototype-non-contact-profiler
#20
Hui-Lin Du, Zhao-Zhong Zhou, Ze-Qing Sun, Bing-Feng Ju, Shaoning Xu, Anyu Sun
A new prototype non-contact profiler based on surface tracking has been specially developed. Surface tracking is carried out by a specially designed dual stage probe system with the aid of a four-Degree Of Freedom high-precision motion platform. The dual stage probe system keeps a short-range optical probe constantly tracking the surface by a self-developed voice coil motor servo, by which a wide measuring range of up to 10 mm is realized. The system performance evaluation including resolution, repeatability, and scanning speed proved the good capability of the new prototype non-contact profiler...
June 2017: Review of Scientific Instruments
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