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https://www.readbyqxmd.com/read/29138647/nodding-syndrome-ns-and-onchocerca-volvulus-ov-in-northern-uganda
#1
David Kitara Lagoro, Denis Anywar Arony
Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. There are recent published information suggesting associations between Nodding Syndrome (NS) with cerebrospinal fluid (CSF) VGKC antibodies and serum leiomidin-1 antibody cross reacting with Onchocerca Volvulus (OV). These findings suggest a neuro-inflammatory cause of NS and they are important findings in the search for the cause of Nodding Syndrome...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29093790/perioperative-evaluation-of-respiratory-muscle-strength-after-scoliosis-correction-in-patients-with-duchenne-muscular-dystrophy
#2
Wataru Saito, Kosuke Mizuno, Gen Inoue, Takayuki Imura, Toshiyuki Nakazawa, Masayuki Miyagi, Eiki Shirasawa, Kentaro Uchida, Masashi Takaso
Study Design: Retrospective cohort study. Purpose: To investigate the effect of spinal correction on respiratory muscle strength in patients with Duchenne muscular dystrophy (DMD). Overview of Literature: Several studies have reported that scoliosis correction in patients with DMD does not improve pulmonary function. In these studies, pulmonary function was evaluated using the traditional spirometric values of percent vital capacity (%VC) and percent forced vital capacity (%FVC)...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29064472/genome-wide-association-studies-of-smooth-pursuit-and-antisaccade-eye-movements-in-psychotic-disorders-findings-from-the-b-snip-study
#3
R Lencer, L J Mills, N Alliey-Rodriguez, R Shafee, A M Lee, J L Reilly, A Sprenger, J E McDowell, S A McCarroll, M S Keshavan, G D Pearlson, C A Tamminga, B A Clementz, E S Gershon, J A Sweeney, J R Bishop
Eye movement deviations, particularly deficits of initial sensorimotor processing and sustained pursuit maintenance, and antisaccade inhibition errors, are established intermediate phenotypes for psychotic disorders. We here studied eye movement measures of 849 participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study (schizophrenia N=230, schizoaffective disorder N=155, psychotic bipolar disorder N=206 and healthy controls N=258) as quantitative phenotypes in relation to genetic data, while controlling for genetically derived ancestry measures, age and sex...
October 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28994268/classification-of-lacrimal-punctal-stenosis-and-its-related-histopathological-feature-in-patients-with-epiphora
#4
Mun Chong Hur, Sang Wook Jin, Mi Sook Roh, Woo Jin Jeong, Won Yeol Ryu, Yoon Hyung Kwon, Hee Bae Ahn
PURPOSE: To evaluate the classification of punctal stenosis based on the shape of the external punctum, clinical characteristics and histopathologic features. METHODS: Patients who experienced tearing and were diagnosed with punctal stenosis were evaluated in this study. Punctal stenosis was classified according to the shape of the lower external punctum, which included membranous type, slit type, horseshoe type, and pinpoint type. Tear meniscus height, 2% fluorescein dye disappearance test and lacrimal pathway irrigation were measured or performed...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28972982/feasibility-of-utilizing-the-sd-bioline-onchocerciasis-igg4-rapid-test-in-onchocerciasis-surveillance-in-senegal
#5
Yakou Dieye, Helen L Storey, Kelsey L Barrett, Emily Gerth-Guyette, Laura Di Giorgio, Allison Golden, Dunia Faulx, Michael Kalnoky, Marie Khemesse Ngom Ndiaye, Ngayo Sy, Malang Mané, Babacar Faye, Mamadou Sarr, Elhadji Mamadou Dioukhane, Roger B Peck, Philippe Guinot, Tala de Los Santos
As effective onchocerciasis control efforts in Africa transition to elimination efforts, different diagnostic tools are required to support country programs. Senegal, with its long standing, successful control program, is transitioning to using the SD BIOLINE Onchocerciasis IgG4 (Ov16) rapid test over traditional skin snip microscopy. The aim of this study is to demonstrate the feasibility of integrating the Ov16 rapid test into onchocerciasis surveillance activities in Senegal, based on the following attributes of acceptability, usability, and cost...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28969662/o-5s-quantitative-real-time-pcr-a-new-diagnostic-tool-for-laboratory-confirmation-of-human-onchocerciasis
#6
Solomon A Mekonnen, Marcus Beissner, Malkin Saar, Solomon Ali, Ahmed Zeynudin, Kassahun Tesfaye, Mulatu G Adbaru, Florian Battke, Sven Poppert, Michael Hoelscher, Thomas Löscher, Gisela Bretzel, Karl-Heinz Herbinger
BACKGROUND: Onchocerciasis is a parasitic disease caused by the filarial nematode Onchocerca volvulus. In endemic areas, the diagnosis is commonly confirmed by microscopic examination of skin snip samples, though this technique is considered to have low sensitivity. The available melting-curve based quantitative real-time PCR (qPCR) using degenerated primers targeting the O-150 repeat of O. volvulus was considered insufficient for confirming the individual diagnosis, especially in elimination studies...
October 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28809073/biocatalytic-stimuli-responsive-asymmetric-triblock-terpolymer-membranes-for-localized-permeability-gating
#7
Jennifer L Poole, Scott Donahue, David Wilson, Yuk Mun Li, Qi Zhang, Yibei Gu, Rachel Ferebee, Zhao Lu, Rachel Mika Dorin, Lawrence F Hancock, Larry Takiff, Ilhem F Hakem, Michael R Bockstaller, Ulrich Wiesner, Jeremy Walker
The functionalization with phosphotriesterase of poly(isoprene-b-styrene-b-4-vinylpyridine)-based nanoporous membranes fabricated by self-assembly and nonsolvent induced phase separation (SNIPS) is shown to enable dynamically responsive membranes capable of substrate-specific and localized gating response. Integration of the SNIPS process with macroporous nylon support layers yields mechanically robust textile-type films with high moisture vapor transport rates that display rapid and local order-of-magnitude modulation of permeability...
October 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28774318/important-progress-towards-elimination-of-onchocerciasis-in-the-west-region-of-cameroon
#8
Guy-Roger Kamga, Fanny N Dissak-Delon, Hugues C Nana-Djeunga, Benjamin D Biholong, Stephen Mbigha Ghogomu, Jacob Souopgui, Joseph Kamgno, Annie Robert
BACKGROUND: After more than a decade of community-directed treatment with ivermectin (CDTI) in the West Region of Cameroon, epidemiological evaluation conducted in 2011 showed that onchocerciasis endemicity was still high in some communities. The conceptual framework for onchocerciasis elimination recommends in such case, to conduct additional phase 1A surveys at intervals of three to four years. Therefore, to assess the progress made towards the elimination of onchocerciasis in the West CDTI projects, we conducted a cross-sectional survey in May 2015 in 15 unevaluated communities where the highest baseline endemicity level were found in 1996...
August 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28743265/the-predictive-value-of-respiratory-function-tests-for-non-invasive-ventilation-in-amyotrophic-lateral-sclerosis
#9
T B M Tilanus, J T Groothuis, J M C TenBroek-Pastoor, T B Feuth, Y F Heijdra, J P L Slenders, J Doorduin, B G Van Engelen, M J Kampelmacher, J Raaphorst
BACKGROUND: Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respiratory function tests, has shown room for improvement. It is currently unknown which respiratory function test predicts an appropriate timing of the initiation of NIV. METHODS: We analysed, retrospectively, serial data of five respiratory function tests: forced vital capacity (FVC), peak cough flow (PCF), maximum inspiratory and expiratory pressure (MIP and MEP) and sniff nasal inspiratory pressure (SNIP) in patients with ALS...
July 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28728441/ability-of-pulmonary-function-decline-to-predict-death-in-amyotrophic-lateral-sclerosis-patients
#10
Irina Enache, Cristina Pistea, Marie Fleury, Mickael Schaeffer, Monique Oswald-Mammosser, Andoni Echaniz-Laguna, Christine Tranchant, Nicolas Meyer, Anne Charloux
OBJECTIVES: Objectives were to evaluate the relative risk of death associated with lung function decline in patients with amyotrophic lateral sclerosis (ALS), and to examine the ability of ALS patients to perform volitional pulmonary function tests (PFTs). METHODS: The PFTs of 256 consecutive patients referred to the Strasbourg University Hospital ALS Centre over an eight-year period were reviewed. Slow vital capacity (VC), maximal inspiratory and expiratory pressures (MIP, MEP), sniff nasal inspiratory pressure (SNIP), and peak cough flow (PCF) were performed at diagnosis and then every four months...
July 20, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28722619/evaluation-of-onchocerciasis-transmission-in-tanzania-preliminary-rapid-field-results-in-the-tukuyu-focus-2015
#11
Heather N Paulin, Andreas Nshala, Akili Kalinga, Upendo Mwingira, Ryan Wiegand, Vitaliano Cama, Paul T Cantey
To compare diagnostic tests for onchocerciasis in a setting that has suppressed transmission, a randomized, age-stratified study was implemented in an area in Tanzania that had received 15 rounds of annual mass drug administration (MDA) with ivermectin. Study participants (N = 948) from 11 villages underwent a questionnaire, skin examination, skin snips, and blood draw. The burden of symptomatic disease was low. Ov-16 antibody rapid diagnostic test (RDT) results were positive in 38 (5.5%) participants, with 1 (0...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28670211/trend-analysis-of-journal-metrics-a-new-academic-library-service
#12
Peter Kokol
OBJECTIVE: Temporal trends in source normalized impact per paper (SNIP) values for the three top-ranking nursing journals were analyzed and compared to explore whether predicting future SNIP values based on trend analysis could be an innovative service provided by librarians. METHODS: The International Journal of Nursing Studies, Journal of Nursing Scholarship, and Journal of Advanced Nursing were the three top-ranked nursing journals according to 2015 SNIP values...
July 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28667981/full-area-covered-3d-profile-measurement-of-special-shaped-optics-based-on-a-new-prototype-non-contact-profiler
#13
Hui-Lin Du, Zhao-Zhong Zhou, Ze-Qing Sun, Bing-Feng Ju, Shaoning Xu, Anyu Sun
A new prototype non-contact profiler based on surface tracking has been specially developed. Surface tracking is carried out by a specially designed dual stage probe system with the aid of a four-Degree Of Freedom high-precision motion platform. The dual stage probe system keeps a short-range optical probe constantly tracking the surface by a self-developed voice coil motor servo, by which a wide measuring range of up to 10 mm is realized. The system performance evaluation including resolution, repeatability, and scanning speed proved the good capability of the new prototype non-contact profiler...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28662432/cathelicidin-augments-vdr-dependent-anti-leishmanial-immune-response-in-indian-post-kala-azar-dermal-leishmaniasis
#14
Sushmita Das, Abul Hasan Sardar, Kumar Abhishek, Ajay Kumar, Vidya Nand Rabidas, Pradeep Das
OBJECTIVES: Indian Post kala-azar dermal leishmaniasis (PKDL) is the cutaneous aftermath of visceral leishmaniasis (VL) caused by L. donovani. Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive. METHODS: Skin snips and blood-derived monocytes of PKDL patients (n=46), before (BT) and after (AT) chemotherapy, were used for this study...
June 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28641033/evaluation-of-planned-bicanalicular-nasolacrimal-tube-retention-in-treating-punctal-stenosis-or-occlusion-secondary-to-trachoma
#15
Rania A Ahmed, Ahmed M Kamal, Mohamed A Zayed
This article evaluates retaining bicanalicular silicone nasolacrimal tube in patients susceptible to restenosis after punctoplasty. Sixty-nine eyes (38 patients) suffering from epiphora due to stenosis or occlusion of both punctae were included in this prospective study. All had 3 snip punctoplasty and bicanalicular silicone nasolacrimal duct insertion. Cases associated with proximal canalicular stenosis or obstructions were excluded. Tolerance to tube presence until the time of loss or removal was evaluated using a score (0 to 2)...
August 2017: Orbit
https://www.readbyqxmd.com/read/28597339/the-clinical-behavior-of-sinonasal-inverted-papilloma-with-cellular-dysplasia-case-series-and-review-of-the-literature
#16
Ahmad Safadi, Daniel Yafit, Sara Abu-Ghanem, Omer J Ungar, Anat Wengier, Avraham Abergel, Dan M Fliss, Ilan Koren
The prognosis and recurrence rate of inverted papilloma (IP) with concomitant cellular dysplasia are not well-delineated. Demographic, clinical and imaging data of all patients who were surgically treated for sinonasal inverted papilloma (SNIP) in our center between 1996 and 2013 were reviewed. Data regarding the coexistence of dysplastic changes or malignancy within the resected tissues were also retrieved. After the exclusion of malignant cases and patients who were lost for follow-up, 92 patients were included in the study...
June 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28594857/noninvasive-assessment-of-respiratory-muscle-strength-and-activity-in-myotonic-dystrophy
#17
Morgana de Araújo Evangelista, Fernando Augusto Lavezzo Dias, Mário Emílio Teixeira Dourado Júnior, George Carlos do Nascimento, Antonio Sarmento, Lucien Peroni Gualdi, Andrea Aliverti, Vanessa Resqueti, Guilherme Augusto de Freitas Fregonezi
OBJECTIVE: To evaluate sensitivity/specificity of the maximum relaxation rate (MRR) of inspiratory muscles, amplitude of electromyographic activity of the sternocleidomastoid (SCM), scalene (SCA), parasternal (2ndIS) and rectus abdominis (RA) muscles; lung function and respiratory muscle strength in subjects with Myotonic dystrophy type 1 (DM1) compared with healthy subjects. DESIGN AND METHODS: Quasi-experimental observational study with control group. MRR of inspiratory muscles, lung function and amplitude of the electromyographic activity of SCM, SCA, 2ndIS and RA muscles during maximum inspiratory pressure (PImax), maximum expiratory pressure (PEmax) and sniff nasal inspiratory pressure (SNIP) tests were assessed in eighteen DM1 subjects and eleven healthy...
2017: PloS One
https://www.readbyqxmd.com/read/28579708/field-based-evidence-of-single-and-few-doses-of-annual-ivermectin-treatment-efficacy-in-eliminating-skin-microfilaria-load-after-a-decade-of-intervention
#18
Hudu O Osue
BACKGROUND: Impact assessment of community-based ivermectin treatment control of onchocerciasis is required to determine its effectiveness. This study was conducted to evaluate geographic coverage and demographic ivermectin treatment compliance. METHODS: The number of village dosage were obtained from the community based distributors. Bioclinical data of participants comprising gender, age, number of treatment received from inception and dosage were obtained. Each participant was subjected to physical examination for palpable nodule and other skin clinical signs and symptoms of onchocerciasis...
March 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28520769/optimal-method-for-assessment-of-respiratory-muscle-strength-in-neuromuscular-disorders-using-sniff-nasal-inspiratory-pressure-snip
#19
COMPARATIVE STUDY
Marta Kaminska, Francine Noel, Basil J Petrof
BACKGROUND: The ability to accurately determine respiratory muscle strength is vitally important in patients with neuromuscular disorders (NMD). Sniff nasal inspiratory pressure (SNIP), a test of inspiratory muscle strength, is easier to perform for many NMD patients than the more commonly used determination of maximum inspiratory pressure measured at the mouth (MIP). However, due to an inconsistent approach in the literature, the optimal technique to perform the SNIP maneuver is unclear...
2017: PloS One
https://www.readbyqxmd.com/read/28508467/keratitis-due-to-microfilariae-in-dogs-a-newly-recognized-disease
#20
Adriana Morales, Eduardo Perlmann, Aline Nayara Vechiato Abelha, Carlos Emilio Levy, Ana Carolina Almeida de Goes, Angélica M V Safatle
Parasitic agents have been associated with keratitis, but a diagnosis of parasitic keratitis has not been commonly made in domestic animals. The purpose of this study was to describe the clinical and histopathological findings in seven dogs with chronic keratitis caused by microfilariae diagnosed in Brazil. All dogs presented with superficial corneal opacities of varying degrees affecting the perilimbal and central regions of the cornea, with other opaque areas appearing as crystalline deposits and corneal vascularization...
May 15, 2017: Veterinary Ophthalmology
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