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https://www.readbyqxmd.com/read/28432463/malignant-transformation-of-sinonasal-inverted-papilloma-and-related-genetic-alterations-a-systematic-review
#1
REVIEW
M Re, F M Gioacchini, A Bajraktari, M Tomasetti, S Kaleci, C Rubini, A Bertini, G Magliulo, E Pasquini
Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation...
April 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28413139/evaluation-of-extensor-mechanism-in-revision-knee-arthroplasty
#2
Vadym Zhamilov, Vasfi Karatosun, Serpil Kalkan, Bayram Unver, Izge Gunal
BACKGROUND: The success of revision total knee arthroplasty depends on adequate exposure that does not produce complications. The purpose of this study was to compare the results of revision total knee arthroplasty between V-Y quadricepsplasty (QP) and quadriceps snip (QS) approaches. METHODS: In the study, 92 knees with follow-up of 12-108 months which were operated by using QP (55) and QS (37) were evaluated retrospectively. Measurements were taken by using universal transparent goniometer, also varus valgus deformities, knee flexion angles, instability, Hospital for Special Surgery and Lower Extremity Functional Scale scores, functional condition of the knee and activity levels of the patients were evaluated cross-sectionally...
March 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28390849/cognitive-burden-of-anticholinergic-medications-in-psychotic-disorders
#3
Seenae Eum, S Kristian Hill, Leah H Rubin, Ryan M Carnahan, James L Reilly, Elena I Ivleva, Sarah K Keedy, Carol A Tamminga, Godfrey D Pearlson, Brett A Clementz, Elliot S Gershon, Matcheri S Keshavan, Richard S E Keefe, John A Sweeney, Jeffrey R Bishop
BACKGROUND: Patients with psychotic disorders are often treated with numerous medications, many of which have anticholinergic activity. We assessed cognition in relation to the cumulative anticholinergic burden of multiple drugs included in treatment regimens of participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. METHOD: Clinically stable participants with schizophrenia (n=206), schizoaffective disorder (n=131), and psychotic bipolar disorder (n=146) were examined...
April 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28383616/-new-bibliometric-indicators-for-the-scientific-literature-an-evolving-panorama
#4
G La Torre, I Sciarra, M Chiappetta, A Monteduro
INTRODUCTION: Bibliometrics is a science which evaluates the impact of the scientific work of a journal or of an author, using mathematical and statistical tools. Impact Factor (IF) is the first bibliometric parameter created, and after it many others have been progressively conceived in order to go beyond its limits. Currently bibliometric indexes are used for academic purposes, among them to evaluate the eligibility of a researcher to compete for the National Scientific Qualification, in order to access to competitive exams to become professor...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28348042/hearing-on-the-fly-the-effects-of-wing-position-on-noctuid-moth-hearing
#5
Shira D Gordon, Elizabeth Klenschi, James F C Windmill
The ear of the noctuid moth has only two auditory neurons, A1 and A2, which function in detecting predatory bats. However, the noctuid's ears are located on the thorax behind the wings. Therefore, since these moths need to hear during flight, it was hypothesized that wing position may affect their hearing. The wing was fixed in three different positions: up, flat, and down. An additional subset of animals was measured with freely moving wings. In order to negate any possible acoustic shadowing or diffractive effects, all wings were snipped, leaving the proximal most portion and the wing hinge intact...
March 27, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28302080/population-based-study-of-the-incidence-of-congenital-hip-dysplasia-in-preterm-infants-from-the-survey-of-neonates-in-pomerania-snip
#6
A E Lange, J Lange, Till Ittermann, M Napp, Paul-Christian Krueger, H Bahlmann, R Kasch, M Heckmann
BACKGROUND: Some etiological factors involved in developmental dysplasia of the hip (DDH) occur in the last trimester of pregnancy, which could result in a decreased incidence of DDH in preterm infants. The aim of this study was to compare the incidence of DDH between preterm and term infants. METHODS: Ultrasound of the hip joint was performed in 2,534 term infants and 376 preterm infants within the population-based Survey of Neonates in Pomerania (SNiP) study. RESULTS: A total of 42 (1...
March 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28298176/semi-automated-tip-snip-cloning-of-restriction-fragments-into-and-out-of-plasmid-polylinkers
#7
Ichiro Matsumura
Synthetic biologists rely on semi-synthetic recombinant plasmids, but DNA synthesis is constrained by practical limits on length, accuracy, and sequence composition. Cloned DNA parts can be assembled into longer constructs via subcloning, but conventional methods are labor-intensive. One-pot recombination reactions are more convenient but harder to troubleshoot, and those that depend on PCR to create fragments with compatible ends necessitate re-sequencing. The Tip Snip protocol described here enables the subcloning of an insert from one plasmid polylinker into another without PCR or gel purification steps...
March 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28286912/the-23rd-scientific-conference-of-the-society-on-neuroimmune-pharmacology
#8
Marcus Kaul
The 23rd Scientific Conference of the Society on Neuroimmune Pharmacology (SNIP) will take place in Philadelphia, PA, USA, from March 29 to April 1, 2017. The conference will present a selection of the latest and most advanced research in the intersecting areas of neuroscience, immunology, pharmacology and its translational aspects.
April 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28264583/crispr-mediated-knockout-of-cybb-in-nsg-mice-establishes-a-model-of-chronic-granulomatous-disease-for-human-stem-cell-gene-therapy-transplants
#9
Colin L Sweeney, Uimook Choi, Chengyu Liu, Sherry Koontz, Seung-Kwon Ha, Harry L Malech
Chronic granulomatous disease (CGD) is characterized by defects in the production of microbicidal reactive oxygen species (ROS) by phagocytes. Testing of gene and cell therapies for the treatment of CGD in human hematopoietic cells requires preclinical transplant models. The use of the lymphocyte-deficient NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl/)SzJ (NSG) mouse strain for human hematopoietic cell xenografts to test CGD therapies is complicated by the presence of functional mouse granulocytes capable of producing ROS for subsequent bacterial and fungal killing...
March 6, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28247489/inorganic-snip-type-double-helices-in-main-group-chemistry
#10
Maximilian Baumgartner, Richard Weihrich, Tom Nilges
Inspired by the synthesis of the first atomic-scale double helix semiconductor SnIP this study deals with the question if more atomistic, inorganic double helix compounds are accessible. With the aid of quantum chemical calculations we have identified 31 candidates by a homoatomic substitution in MXPn, varying the group 4 M-element from Si to Pb, the group 7 X-element from F to I and replacing the pnictide (Pn) phosphorus by arsenic. The double-helical structure of SnIP has been used as the starting model for all candidates and the electronic structure and vibrational spectra were determined within the Framework of Density Functional Theory (DFT)...
March 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28225656/school-nurse-evaluation
#11
Vickie H Southall, Janet B Wright, Tia Campbell, Margaret K Bassett, Julie A Strunk, Suzanne E Trotter
Evaluation of one's school nurse practice is one standard in the school nurse's scope and standards of professional practice. The Virginia School Nurse Institute Partnership (SNIP) identified the need to develop a concise self-evaluation tool that school nurses and their nurse and non-nurse employers could use to appropriately document a school nurse's practice. The purpose of this article is to provide a self-evaluation tool that the school nurse and his or her employers can use to evaluate professional school nurse practice...
March 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28142345/total-knee-arthroplasty-conversion-for-patients-with-ankylosed-knees
#12
Hee-June Kim, Jong-Uk Mun, Kwang-Hwan Kim, Hee-Soo Kyung
INTRODUCTION: The purpose of this study was to evaluate the results of total knee arthroplasty for patients with ankylosed knees. METHODS: We evaluated seven patients (10 knees) who underwent total knee arthroplasties for ankylosed knees from 1995 to 2008. There were two men and five women, with a mean age of 44.1 years (42-48 years). The mean follow-up period was 10.2 years (1-19.5 years). A rectus snip was performed in all cases, and V-Y quadricepsplasty was used in one case of severe quadriceps contracture...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28034767/interruption-of-the-transmission-of-onchocerca-volvulus-in-the-kashoya-kitomi-focus-western-uganda-by-long-term-ivermectin-treatment-and-elimination-of-the-vector-simulium-neavei-by-larviciding
#13
T Lakwo, R Garms, J Wamani, E M Tukahebwa, E Byamukama, A W Onapa, E Tukesiga, J Katamanywa, S Begumisa, P Habomugisha, D Oguttu, E Byamukama, F Richards, T R Unnasch, M Katabarwa
Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate(®), EC500) against Simulium neavei were conducted...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/27926918/evaluation-of-lymphatic-filariasis-and-onchocerciasis-in-three-senegalese-districts-treated-for-onchocerciasis-with-ivermectin
#14
Nana O Wilson, Alioune Badara Ly, Vitaliano A Cama, Paul T Cantey, Daniel Cohn, Lamine Diawara, Abdel Direny, Mawo Fall, Karla R Feeser, LeAnne M Fox, Achille Kabore, Amadou F Seck, Ngayo Sy, Daouda Ndiaye, Christine Dubray
In Africa, onchocerciasis and lymphatic filariasis (LF) are co-endemic in many areas. Current efforts to eliminate both diseases are through ivermectin-based mass drug administration (MDA). Years of ivermectin distribution for onchocerciasis may have interrupted LF transmission in certain areas. The Kédougou region, Senegal, is co-endemic for LF and onchocerciasis. Though MDA for onchocerciasis started in 1988, in 2014 albendazole had not yet been added for LF. The objective of this study was to assess in an integrated manner the LF and onchocerciasis status in the three districts of the Kédougou region after ≥10 years of ivermectin-based MDA...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27906100/an-isothermal-dna-amplification-method-for-detection-of-onchocerca-volvulus-infection-in-skin-biopsies
#15
Ole Lagatie, Michelle Merino, Linda Batsa Debrah, Alexander Y Debrah, Lieven J Stuyver
BACKGROUND: Diagnostic procedures for the diagnosis of infection with the nematode parasite Onchocerca volvulus are currently based on the microscopic detection of microfilariae in skin biopsies. Alternative approaches based on amplification of parasitic DNA in these skin biopsies are currently being explored. Mostly this is based on the detection of the O-150 repeat sequence using PCR based techniques. METHODS: An isothermal, loop-mediated amplification method has been designed using the mitochondrial O...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27842567/still-mesoendemic-onchocerciasis-in-two-cameroonian-community-directed-treatment-with-ivermectin-projects-despite-more-than-15-years-of-mass-treatment
#16
Guy-Roger Kamga, Fanny N Dissak-Delon, Hugues C Nana-Djeunga, Benjamin D Biholong, Stephen Mbigha-Ghogomu, Jacob Souopgui, Honorat G M Zoure, Michel Boussinesq, Joseph Kamgno, Annie Robert
BACKGROUND: After more than a decade of community-directed treatment with ivermectin (CDTI) in Centre and Littoral Regions of Cameroon, onchocerciasis endemicity was still high in some communities according to the 2011 epidemiological evaluations. Some corrective measures were undertaken to improve the CDTI process and therefore reduce the burden of the disease. The objective of the present study was to assess the progress made towards the elimination of onchocerciasis in the Centre 1 and Littoral 2 CDTI projects where the worst performances were found in 2011...
November 14, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27814962/neural-complexity-as-a-potential-translational-biomarker-for-psychosis
#17
Brandon Hager, Albert C Yang, Roscoe Brady, Shashwath Meda, Brett Clementz, Godfrey D Pearlson, John A Sweeney, Carol Tamminga, Matcheri Keshavan
BACKGROUND: The adaptability of the human brain to the constantly changing environment is reduced in patients with psychotic disorders, leading to impaired cognitive functions. Brain signal complexity, which may reflect adaptability, can be readily quantified via resting-state functional magnetic resonance imaging (fMRI) signals. We hypothesized that resting-state brain signal complexity is altered in psychotic disorders, and is correlated with cognitive impairment. METHODS: We assessed 156 healthy controls (HC) and 330 probands, including 125 patients with psychotic bipolar disorder (BP), 107 patients with schizophrenia (SZ), 98 patients with schizoaffective disorder (SAD) and 230 of their unaffected first-degree relatives (76 BPR, 79 SADR, and 75 SZR) from four sites of the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27789186/novel-gene-brain-structure-relationships-in-psychotic-disorder-revealed-using-parallel-independent-component-analyses
#18
Neeraj Tandon, Pranav Nanda, Jaya L Padmanabhan, Ian T Mathew, Shaun M Eack, Balaji Narayanan, Shashwath A Meda, Sarah E Bergen, Gualbert Ruaño, Andreas Windemuth, Mohan Kocherla, Tracey L Petryshen, Brett Clementz, John Sweeney, Carol Tamminga, Godfrey Pearlson, Matcheri S Keshavan
BACKGROUND: Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap with regard to symptoms, structural and functional brain abnormalities, and genetic risk factors. Neurobiological pathways connecting genes to clinical phenotypes across the spectrum from schizophrenia to psychotic bipolar disorder remain largely unknown. METHODS: We examined the relationship between structural brain changes and risk alleles across the psychosis spectrum in the multi-site Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) cohort...
April 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/27751623/phrenic-nerve-stimulation-is-more-sensitive-than-ultrasound-measurement-of-diaphragm-thickness-in-assessing-early-als-progression
#19
COMPARATIVE STUDY
Susana Pinto, Pedro Alves, Michael Swash, Mamede de Carvalho
AIMS OF THE STUDY: To compare the assessment of respiratory decline with conventional tests, measurement of diaphragm compound muscle action potential (CMAP) to phrenic nerve stimulation and diaphragm thickness to ultrasound (US) investigation in amyotrophic lateral sclerosis (ALS) patients followed for a short period of time. PATIENTS AND METHODS: We evaluated in 40 consecutive ALS patients, the clinical functional scale (ALSFRS-R), forced vital capacity (FVC), maximal voluntary ventilation (MVV), maximal inspiratory (MIP) and expiratory (MEP) pressures, sniff nasal inspiratory pressure (SNIP), Diaphragm-CMAP (latency and amplitude) and diaphragm US (maximal and minimal diaphragm thickness during full inspiration and expiration, respectively)...
February 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/27698270/onchocerciasis-elimination-from-africa-one-step-in-northern-sudan
#20
James W Kazura
Onchocerciasis is one of the two filarial helminth "neglected tropical diseases" (the other being lymphatic filariasis) that has been targeted for geographically local elimination followed by global eradication. The last known areas of Onchocerca volvulus transmission in the Americas have recently been reported to be eliminated. In contrast, achieving metrics for interruption of O. volvulus transmission in Africa, thus removing the requirement for continued monitoring and mass drug administration (MDA) with ivermectin, has been more challenging...
October 3, 2016: American Journal of Tropical Medicine and Hygiene
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