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https://www.readbyqxmd.com/read/29244096/treatment-of-pulmonary-tuberculosis-past-and-present
#1
Dmitry Borisovich Giller, Boris Dmitrievich Giller, Galina Vitalievna Giller, Galina Vladimirovna Shcherbakova, Anuar Bahtibaevich Bizhanov, Inga Igorevna Enilenis, Aleksey Aleksandrovich Glotov
OBJECTIVES: Surgical interventional has been key in the treatment of tuberculosis (TB) for a long time. Its importance diminished after the emergence of chemotherapy. However, the spread of rapid multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB has led us to return to surgery to treat TB. Today, every second patient in Russia with destructive TB has either MDR or XDR TB, which is the reason for the low efficacy of conservative treatment. In 2015, treatment with drugs resulted in clinical recovery in only 29...
December 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29238270/treatment-of-latent-tuberculosis-infection
#2
REVIEW
Patrick Tang, James Johnston
The treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) elimination in regions that have a low incidence of TB. However, the decision to treat individuals with LTBI must consider the limitations of current diagnostic tests for LTBI, the risk of developing active TB disease, the potential adverse effects from chemoprophylactic therapy, and the importance of treatment adherence. When an individual has been diagnosed with LTBI and active TB has been ruled out, this is followed by an evaluation of the risks and benefits of LTBI treatment within the context of the regional epidemiology of TB and public health priorities...
2017: Current Treatment Options in Infectious Diseases
https://www.readbyqxmd.com/read/29229108/infection-control-genetic-assessment-of-drug-resistance-and-drug-susceptibility-testing-in-the-current-management-of-multidrug-extensively-resistant-tuberculosis-m-xdr-tb-in-europe-a-tuberculosis-network-european-trialsgroup-tbnet-study
#3
Graham H Bothamley, Christoph Lange
AIM: Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. METHODS: TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29212699/rapid-microarray-based-detection-of-rifampicin-isoniazid-and-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-using-a-single-cartridge
#4
Juliane Havlicek, Beatrice Dachsel, Peter Slickers, Sönke Andres, Patrick Beckert, Silke Feuerriegel, Stefan Niemann, Matthias Merker, Ines Labugger
Rapid and robust identification of mutations in Mycobacterium tuberculosis complex (MTBC) strains mediating multidrug and extensively drug-resistant (M/XDR) phenotypes is crucial to combat the MDR tuberculosis (TB) epidemic. Currently available molecular TB drug susceptibility tests are either restricted to single targets/drugs (i.e. Xpert MTB/RIF) or aid the risk of cross-contaminations due to the design limitations of the open platform (i.e. line probe assays).With a good understanding of the technical and commercial boundaries we designed a test cartridge with an introduction of dried reagents, based on an oligonucleotide array, which has the ability to identify MTBC strains resistant to isoniazid, rifampicin and the fluoroquinolones...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29201659/mental-disorders-and-drug-alcohol-use-in-patients-commencing-extensively-drug-resistant-tuberculosis-treatment
#5
J Scuffell, D Boccia, F Garcia Velarde, S R Leon, G Raviola, L Lecca, J T Galea
Mental disorders and alcohol/drug use worsen treatment outcomes for multidrug-resistant tuberculosis (TB), but data are lacking for extensively drug-resistant (XDR) TB. We investigated the association of baseline mental disorders and alcohol/drug use on XDR-TB treatment outcomes in a retrospective study of 53 XDR-TB Peruvian patients during 2010-2012. Logistic regression estimated the odds ratios for unfavourable XDR-TB treatment outcomes. Overall treatment success was 25%. Mental disorders and drug/alcohol use were found in respectively 22...
September 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29184888/targeting-dna-replication-and-repair-for-the-development-of-novel-therapeutics-against-tuberculosis
#6
REVIEW
Michael A Reiche, Digby F Warner, Valerie Mizrahi
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious disease which results in approximately 10 million incident cases and 1.4 million deaths globally each year, making it the leading cause of mortality from infection. An effective frontline combination chemotherapy exists for TB; however, this regimen requires the administration of four drugs in a 2 month long intensive phase followed by a continuation phase of a further 4 months with two of the original drugs, and is only effective for the treatment of drug-sensitive TB...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29183553/childhood-multidrug-resistant-tuberculosis-in-the-european-union-and-european-economic-area-an-analysis-of-tuberculosis-surveillance-data-from-2007-to-2015
#7
Csaba Ködmön, Martin van den Boom, Phillip Zucs, Marieke Johanna van der Werf
BackgroundConfirming tuberculosis (TB) in children and obtaining information on drug susceptibility is essential to ensure adequate treatment. We assessed whether there are gaps in diagnosis and treatment of multidrug-resistant (MDR) TB in children in the European Union and European Economic Area (EU/EEA), quantified the burden of MDR TB in children and characterised cases. Methods: We analysed surveillance data from 2007 to 2015 for paediatric cases younger than 15 years. Results: In that period, 26 EU/EEA countries reported 18,826 paediatric TB cases of whom 4,129 (21...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29175351/prevalence-associated-factors-outcomes-and-transmission-of-extensively-drug-resistant-tuberculosis-among-multidrug-resistant-tuberculosis-patients-in-s%C3%A3-o-paulo-brazil-a-cross-sectional-study
#8
Juliana Failde Gallo, Juliana Maira Watanabe Pinhata, Vera Simonsen, Vera Maria Neder Galesi, Lucilaine Ferrazoli, Rosângela Siqueira de Oliveira
OBJECTIVES: This study aimed to describe the prevalence, associated factors, treatment outcomes and transmission of extensively drug-resistant tuberculosis (XDR-TB) in the state of São Paulo, Brazil, in the period of 2011 to 2013. METHODS: Drug susceptibility testing to 1st and 2nd line drugs was performed by BACTEC™ MGIT™ 960 and molecular typing, by RFLP-IS6110. Clinical, epidemiological and demographic data were obtained from surveillance information systems for TB...
November 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29174699/neoteric-advancement-in-tb-drugs-and-an-overview-on-the-anti-tubercular-role-of-peptides-through-computational-approaches
#9
REVIEW
Ameer Khusro, Chirom Aarti, Alberto Barbabosa-Pliego, Abdelfattah Z M Salem
Tuberculosis (TB) is a devastating threat to human health whose treatment without the emergence of drug resistant Mycobacterium tuberculosis (M. tuberculosis) is the million-dollar question at present. The pathogenesis of M. tuberculosis has been extensively studied which represents unique defence strategies by infecting macrophages. Several anti-tubercular drugs with varied mode of action and administration from diversified sources have been used for the treatment of TB that later contributed to the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB)...
November 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29174549/identification-and-characterization-of-potential-druggable-targets-among-hypothetical-proteins-of-extensively-drug-resistant-mycobacterium-tuberculosis-xdr-kzn-605-through-subtractive-genomics-approach
#10
Reaz Uddin, Quratulain Nehal Siddiqui, Syed Sikander Azam, Bibi Saima, Abdul Wadood
Among the resistant isolates of tuberculosis (TB), the multidrug resistance tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) are the areas of growing concern for which the front-line antibiotics are no more effective. As a result, the search of new therapeutic targets against TB is an imperative need of time. On the other hand, the target identification is an a priori step in drug discovery based research. Furthermore, the availability of the complete proteomic data of extensively drug resistant Mycobacterium tuberculosis (XDR-MTB) made it possible to carry out in silico analysis for the discovery of new drug targets...
November 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29133554/what-is-resistance-impact-of-phenotypic-versus-molecular-drug-resistance-testing-on-multi-and-extensively-drug-resistant-tuberculosis-therapy
#11
Jan Heyckendorf, Sönke Andres, Claudio U Köser, Ioana D Olaru, Thomas Schön, Erik Sturegård, Patrick Beckert, Viola Schleusener, Thomas A Kohl, Doris Hillemann, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Stefan Niemann, Christoph Lange, Matthias Merker
Rapid and accurate drug-susceptibility testing (DST) is essential for the treatment of multi- and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST) using BACTEC 960 MGIT or Löwenstein-Jensen to construct M/XDR-TB treatment regimens for a cohort of 25 consecutive M/XDR-TB patients and 15 possible anti-TB drugs.Genotypic DST results from Cepheid GeneXpert MTB/RIF (Xpert) and line probe assays (LPAs: Hain GenoType MTBDRplus 2.0 and MTBDRsl 2...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29129484/detection-of-resistance-to-fluoroquinolones-and-injectable-drugs-among-antituberculosis-drugs-by-allele-specific-primer-extension-on-a-microsphere-based-platform
#12
Kyungjong Kim, Jeong Seong Yang, Hee Baeg Choi, Seung Heon Lee
Molecular drug susceptibility testing (DST) for antituberculosis drugs is important for improving the efficacy of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) treatment. In this study, we developed a molecular high-throughput assay system based on allele-specific primer extension (ASPE) and MagPlex-TAG microspheres, referred to here as TAG-ASPE, which can detect mutations related to resistance to injectable second-line drugs and fluoroquinolones. Target genes were amplified by multiplex PCR using DNA from H37Rv and 190 clinical Mycobacterium tuberculosis strains and extended by ASPE using 22 ASPE primers...
November 9, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29094039/host-directed-therapeutic-strategies-for-tuberculosis
#13
REVIEW
Afsal Kolloli, Selvakumar Subbian
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality in humans worldwide. Currently, the standard treatment for TB involves multiple antibiotics administered for at least 6 months. Although multiple antibiotics therapy is necessary to prevent the development of drug resistance, the prolonged duration of treatment, combined with toxicity of drugs, contributes to patient non-compliance that can leads to the development of drug-resistant Mtb (MDR and XDR) strains...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29093504/mycobacterial-genomic-dna-from-used-xpert-mtb-rif-cartridges-can-be-utilised-for-accurate-second-line-genotypic-drug-susceptibility-testing-and-spoligotyping
#14
Rouxjeane Venter, Brigitta Derendinger, Margaretha de Vos, Samantha Pillay, Tanya Dolby, John Simpson, Natasha Kitchin, Ashley Ruiters, Paul D van Helden, Robin M Warren, Grant Theron
Xpert MTB/RIF (Xpert) is a widely-used test for tuberculosis (TB) and rifampicin-resistance. Second-line drug susceptibility testing (DST), which is recommended by policymakers, typically requires additional specimen collection that delays effective treatment initiation. We examined whether cartridge extract (CE) from used Xpert TB-positive cartridges was, without downstream DNA extraction or purification, suitable for both genotypic DST (MTBDRplus, MTBDRsl), which may permit patients to rapidly receive a XDR-TB diagnosis from a single specimen, and spoligotyping, which could facilitate routine genotyping...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092043/emerging-resistant-clones-of-mycobacterium-tuberculosis-in-a-spatiotemporal-context
#15
Anna Vyazovaya, Klavdia Levina, Viacheslav Zhuravlev, Piret Viiklepp, Marge Kütt, Igor Mokrousov
Objectives: We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by enhanced interaction with the EU since 1991. Methods: The study sample included M. tuberculosis isolates from patients newly diagnosed with TB in 2014 in North Estonia (including the capital Tallinn)...
October 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29066216/performance-of-the-genotype-mtbdrsl-assay-for-the-detection-second-line-anti-tuberculosis-drug-resistance
#16
Young Seok Lee, Bo Young Lee, Kyung-Wook Jo, Tae Sun Shim
The rapid detection of drug-resistant tuberculosis (TB) is important to improve treatment outcomes and prevent disease transmission. The GenoType MTBDRsl assay (MTBDRsl assay) was developed to detect fluoroquinolone (FQ) and second-line injectable drug (SLID) resistance. The aim of this study was to evaluate the performance and clinical utility of MTBDRsl assay. We retrospectively reviewed patient medical records with MTBDRsl assay data between December 2011 and February 2017. MTBDRsl assay results were compared with that of phenotypic drug susceptibility testing...
October 20, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29061759/in-vitro-activity-and-mic-of-sitafloxacin-against-mdr-xdr-tb-isolated-in-thailand
#17
Manoon Leechawengwongs, Therdsak Prammananan, Sarinya Jaitrong, Pamaree Billamas, Nampueng Makhao, Nongnard Thamnongdee, Arirat Thanormchat, Arisa Phurattanakornkul, Somcharn Rattanarangsee, Chate Ratanajaraya, Areeya Disratthakit, Angkana Chaiprasert
Later-generation of fluoroquinolones (FQs) have been shown to be more active against drug-resistant Mycobacterium tuberculosis strains than early-generation FQs such as ofloxacin. Sitafloxacin (STFX) is a fourth-generation fluoroquinolone with in vitro activity against a broad range of bacteria, including M. tuberculosis This study aimed to determine the in vitro activity of STFX against all groups of drug-resistant strains, including multidrug-resistant tuberculosis (MDR-TB); MDR-TB with quinolone-resistance (pre-XDR); and extensively drug-resistant (XDR) strains...
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29050768/single-nucleotide-polymorphisms-in-efflux-pumps-genes-in-extensively-drug-resistant-mycobacterium-tuberculosis-isolates-from-pakistan
#18
Akbar Kanji, Rumina Hasan, Asho Ali, Ambreen Zaver, Ying Zhang, Kehkashan Imtiaz, Wanliang Shi, Taane G Clark, Ruth McNerney, Jody Phelan, Shoaib Rao, Samreen Shafiq, Zahra Hasan
It is challenging to understand mechanisms of drug resistance in Mycobacterium tuberculosis (MTB) due to the large variability in resistance associated genes. Efflux pump genes contribute to drug resistance and thus add to this complexity. Efflux pump gene protein superfamilies have been characterized by genome analysis of drug resistant strains and through in vitro transcriptional studies. However, there is limited information regarding efflux pump genes in extensively drug resistant (XDR) tuberculosis (TB) isolates...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29041901/prevalence-of-drug-resistant-pulmonary-tuberculosis-in-india-systematic-review-and-meta-analysis
#19
Vishal Goyal, Vijay Kadam, Prashant Narang, Vikram Singh
BACKGROUND: Drug-resistant pulmonary tuberculosis (DR-TB) is a significant public health issue that considerably deters the ongoing TB control efforts in India. The purpose of this review was to investigate the prevalence of DR-TB and understand the regional variation in resistance pattern across India from 1995 to 2015, based on a large body of published epidemiological studies. METHODS: A systematic review of published studies reporting prevalence of DR-TB from biomedical databases (PubMed and IndMed) was conducted...
October 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29040413/bilateral-cavitary-multidrug-or-extensively-drug-resistant-tuberculosis-role-of-surgery
#20
Galina Yu Marfina, Kirill B Vladimirov, Armen O Avetisian, Anna A Starshinova, Grigorii G Kudriashov, Evgenii G Sokolovich, Piotr K Yablonskii
OBJECTIVES: Cavitary disease and bilateral lesions are among the risk factors for poor outcome of pulmonary tuberculosis (TB). Our aim was to explore the value and limits of surgery in patients with advanced TB. METHODS: A retrospective study of 57 consecutive patients who underwent thoracic surgery for culture-positive bilateral cavitary pulmonary TB was performed. Forty-four (77.2%) patients were men and 13 (22.8%) patients were women; their ages were in the range of 18-61 years...
October 10, 2017: European Journal of Cardio-thoracic Surgery
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