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multidrug resistant tuberculosis

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https://www.readbyqxmd.com/read/29785129/performance-of-the-abbott-realtime-mtb-rif-inh-resistance-assay-when-used-to-test-mycobacterium-tuberculosis-specimens-from-bangladesh
#1
Joshua Kostera, Gregor Leckie, Klara Abravaya, Hong Wang
Introduction: The Abbott RealTime MTB RIF/INH Resistance Assay (RT MTB RIF/INH) is an assay for the detection of rifampicin (RIF)- and/or isoniazid (INH)-resistant Mycobacterium tuberculosis (MTB). The assay can be used to test sputum, bronchial alveolar lavage, and N-Acetyl-L-Cysteine (NALC)/NaOH pellets prepared from these samples. The assay can be used in direct testing mode, or in reflex mode following a MTB positive result produced by its companion assay, Abbott RT MTB. Methods: In this study, the direct testing mode was used to test paired sputum and NALC/NaOH pellets prepared from sputum collected from Bangladesh TB patients...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29783081/recent-technological-advancements-in-tuberculosis-diagnostics-a-review
#2
REVIEW
Shagun Gupta, Vipan Kakkar
Early diagnosis and on-time effective treatment are indispensable for Tuberculosis (TB) control - a life threatening infectious communicable disease. The conventional techniques for diagnosing TB normally take two to three weeks. This delay in diagnosis and further increase in detection complexity due to the emerging risks of XDR-TB (Extensively drug Resistant-TB) and MDR-TB (Multidrug Resistant-TB) are evoking interest of researchers in the field of developing rapid TB detection techniques such as biosensing and other point-of-care (POC) techniques...
May 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29779778/identification-of-tb-e12-as-a-novel-ftsz-inhibitor-with-anti-tuberculosis-activity
#3
Yuan Lin, Hongjuan Zhang, Ningyu Zhu, Xia Wang, Yanxing Han, Minghua Chen, Jiandong Jiang, Shuyi Si
The global pandemic of multidrug-resistant (MDR) Mycobacterium tuberculosis (TB) drives for more effective anti-TB drugs with new drug target. Filamentous temperature sensitive protein Z (FtsZ), a GTP dependent prokaryotic cell division protein, forms a dynamic Z-ring in the center of the cell. Differences between bacterial FtsZ and eukaryotic tubulin make FtsZ a highly attractive drug target. In this study, we used phenotype screening of M. smegmatis and model screening targeting M. tuberculosis FtsZ (Mtb-FtsZ) to identify a hit compound TB-E12...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779772/dissecting-whole-genome-sequencing-based-online-tools-for-predicting-resistance-in-mycobacterium-tuberculosis-can-we-use-them-for-clinical-decision-guidance
#4
Rita Macedo, Alexandra Nunes, Isabel Portugal, Sílvia Duarte, Luís Vieira, João Paulo Gomes
Whole-genome sequencing (WGS)-based bioinformatics platforms for the rapid prediction of resistance will soon be implemented in the Tuberculosis (TB) laboratory, but their accuracy assessment still needs to be strengthened. Here, we fully-sequenced a total of 54 multidrug-resistant (MDR) and five susceptible TB strains and performed, for the first time, a simultaneous evaluation of the major four free online platforms (TB Profiler, PhyResSE, Mykrobe Predictor and TGS-TB). Overall, the sensitivity of resistance prediction ranged from 84...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779771/genetic-diversity-of-mycobacterium-tuberculosis-isoniazid-monoresistant-and-multidrug-resistant-in-rio-grande-do-sul-a-tuberculosis-high-burden-state-in-brazil
#5
Leonardo Souza Esteves, Elis Regina Dalla Costa, Sidra Ezidio Gonçalves Vasconcellos, Andrei Vargas, Sérgio Luis Montego Ferreira Junior, Maria Laura Halon, Marta Osorio Ribeiro, Rodrigo Rodenbusch, Harrison Magdinier Gomes, Philip N Suffys, Maria Lucia R Rossetti
Tuberculosis (TB) remains a major public health problem in the world and Brazil is among the countries with the highest incidence and prevalence rates, and Rio Grande do Sul, a Brazilian state, occupy a prominent position. Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) further aggravates this scenario, making it more difficult to treat and control the disease. Isoniazid monoresistance (IMR) may increase the risk of progression to MDR-TB and treatment failure. However, most drug resistance molecular tests only focus on detecting rifampicin (RIF) resistance...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779766/should-all-suspected-tuberculosis-cases-in-high-income-countries-be-tested-with-genexpert
#6
Venanzio Vella, Agnieszka Broda, Francis Drobniewski
In countries with a low incidence of multidrug-resistant tuberculosis (MDR-TB), universal testing with GeneXpert might not be always cost-effective. This study provides hospital managers in low MDR-TB incidence countries with criteria on when decentralised universal GeneXpert testing would make sense. The alternatives taken into consideration include: universal microbiological culture and drug susceptibility testing (DST) only (comparator); as above but with concurrent centralized GeneXpert in a referral laboratory vs a decentralized GeneXpert system in every hospital to test smear-positive cases only; as above but testing all samples with GeneXpert regardless of smear status...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29770053/tuberculosis-drug-resistance-in-canada-2006-2016
#7
V Gallant, J Vachon, W Siu
Background: Drug-resistant strains of tuberculosis (TB) pose a serious threat to TB prevention and control efforts. The Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) was created in 1998 to monitor emerging trends and patterns in TB drug resistance in Canada. Objective: To present a descriptive overview of TB drug resistance data collected through the CTBLSS for the years 2006 to 2016 in Canada, with a focus on 2016. Methods: The CTBLSS is an isolate-based surveillance system designed to collect data on TB drug resistance across Canada...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29765372/is-iqg-607-a-potential-metallodrug-or-metallopro-drug-with-a-defined-molecular-target-in-mycobacterium-tuberculosis
#8
REVIEW
Bruno L Abbadi, Valnês da Silva Rodrigues-Junior, Adilio da Silva Dadda, Kenia Pissinate, Anne D Villela, Maria M Campos, Luiz G de França Lopes, Cristiano V Bizarro, Pablo Machado, Eduardo H S Sousa, Luiz A Basso
The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents. INH is activated by the mycobacterial katG -encoded catalase-peroxidase, forming an acylpyridine fragment that is covalently attached to the C4 of NADH. This isonicotinyl-NAD adduct inhibits the activity of 2- trans -enoyl-ACP(CoA) reductase (InhA), which plays a role in mycolic acid biosynthesis. A metal-based INH analog, Na3 [FeII (CN)5 (INH)]·4H2 O, IQG-607, was designed to have an electronic redistribution on INH moiety that would lead to an intramolecular electron transfer to bypass KatG activation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29763750/genome-sequence-and-analysis-of-mycobacterium-tuberculosis-strain-swlpk
#9
Muhammad Ibrahim, Asma Muhammad Yar, Ghunva Zaman, Changhui Yan, Muhammad Khurshid, Habib Bokhari
OBJECTIVES: Multidrug resistant Mycobacterium tuberculosis poses a global threat, particularly in developing countries such as Pakistan. Genome sequencing, comparative genomic analysis, and drug resistance gene analysis, could be beneficial for understanding and monitoring M. tuberculosis disease severity in Pakistan by elucidating the biology of M. tuberculosis. METHODS: In this study, we sequenced, assembled, and annotated a draft genome of M. tuberculosis strain swlpk using the Illumina MiSeq 300PE throughput 2M system...
May 12, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29755957/molecular-targets-related-drug-resistance-mechanisms-in-mdr-xdr-and-tdr-mycobacterium-tuberculosis-strains
#10
REVIEW
H M Adnan Hameed, Md Mahmudul Islam, Chiranjibi Chhotaray, Changwei Wang, Yang Liu, Yaoju Tan, Xinjie Li, Shouyong Tan, Vincent Delorme, Wing W Yew, Jianxiong Liu, Tianyu Zhang
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis . Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29755542/design-synthesis-and-antitubercular-evaluation-of-novel-series-of-pyrazinecarboxamide-metal-complexes
#11
Mohsin Ali, Mansoor Ahmed, Saleem Hafiz, Mustafa Kamal, Majid Mumtaz, Seyed Abdulmajid Ayatollahi
The interest in the synthesis of metallic complexes of different drugs to make them more efficient in biological environment of the human body is seen for the last few decades. Wide range of metal complexes are already used in clinical practice which encourages additional research for innovating new metal based drugs, such as metal-mediated antibiotics, anti-parasitic, antiviral, antibacterial, and anticancer compounds. Tuberculosis has been known as one of the most disastrous disease putting burden on health system worldwide...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29742640/treatment-of-multidrug-resistant-tuberculosis-infection-in-children
#12
Andrea T Cruz, Anthony J Garcia-Prats, Jennifer Furin, James A Seddon
No abstract text is available yet for this article.
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29742052/clinical-and-drug-resistance-characteristics-of-new-pediatric-tuberculosis-cases-in-northern-china
#13
Ting Wang, Fang Dong, Qin-Jing Li, Qing-Qin Yin, Wen-Qi Song, Igor Mokrousov, Wei-Wei Jiao, A-Dong Shen
AIM: The aim of this study was to evaluate the clinical features and characteristics of drug resistance in newly diagnosed pediatric tuberculosis (TB) patients in northern China. METHODS: Mycobacterium tuberculosis isolates were collected from September 2010 to October 2016 at the Beijing Children's Hospital. Patients were divided into two groups (resistant to at least one drug and pan-susceptible) according to drug susceptibility testing (DST) results. RESULTS: A total of 132 new cases, mainly from northern China (87...
May 9, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29735562/impact-of-clofazimine-dosing-on-treatment-shortening-of-the-first-line-regimen-in-a-mouse-model-of-tuberculosis
#14
Nicole C Ammerman, Rosemary V Swanson, Elaine M Bautista, Deepak V Almeida, Vikram Saini, Till F Omansen, Haidan Guo, Yong Seok Chang, Si-Yang Li, Asa Tapley, Rokeya Tasneen, Sandeep Tyagi, Fabrice Betoudji, Chivonne Moodley, Bongani Ngcobo, Logan Pillay, Linda A Bester, Sanil D Singh, Richard E Chaisson, Eric Nuermberger, Jacques H Grosset
The anti-leprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment-shortening when added to the first-line regimen for drug-susceptible tuberculosis in a mouse model. However, clofazimine causes dose- and duration-dependent skin discoloration in patients, and the optimal clofazimine dosing strategy in the context of the first-line regimen is unknown. We utilized a well-established mouse model to systematically address the impact of duration, dose, and companion drugs on the treatment-shortening activity of clofazimine in the first-line regimen...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29721826/importance-of-differential-identification-of-mycobacterium-tuberculosis-strains-for-understanding-differences-in-their-prevalence-treatment-efficacy-and-vaccine-development
#15
REVIEW
Hansong Chae, Sung Jae Shin
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune response and to evade killing by drugs, resulting in the breakdown of BCG vaccine-conferred anti-TB immunity and development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Although genetic components of the genomes of the Mtb complex strains are highly conserved, showing over 99% similarity to other bacterial genera, recently accumulated evidence suggests that the genetic diversity of the Mtb complex strains has implications for treatment outcomes, development of MDR/XDR Mtb, BCG vaccine efficacy, transmissibility, and epidemiological outbreaks...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29714162/exhaled-nitric-oxide-is-not-a-biomarker-for-pulmonary-tuberculosis
#16
José W López, Maria-Cristina I Loader, Dan Smith, Dan Pastorius, Marjory Bravard, Luz Caviedes, Karina M Romero, Taryn Clark, William Checkley, Eduardo Ticona, Jon S Friedland, Robert H Gilman
To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60)...
April 30, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29712658/determination-of-mic-distribution-and-mechanisms-of-decreased-susceptibility-to-bedaquiline-among-clinical-isolates-of-mycobacterium-abscessus
#17
Bing Li, Meiping Ye, Qi Guo, Zhemin Zhang, Shiyi Yang, Wei Ma, Fangyou Yu, Haiqing Chu
Chemotherapeutic options are very limited against Mycobacterium abscessus infections. Bedaquiline, a new anti-tuberculosis drug, is effective for the treatment of multidrug-resistant TB. However, little data is available on bedaquiline in treating M. abscessus infections. In this study, we reported the in vitro susceptibility profile of M. abscessus clinical isolates to bedaquiline and investigated the potential molecular mechanisms of decreased susceptibility. A total of 197 M. abscessus clinical isolates were collected from sputum and bronchoalveolar fluid of patients with lung infections...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29709976/tuberculosis-disease-among-healthcare-workers-clinical-microbiological-characteristics-and-treatment-outcomes-at-chiang-mai-university-hospital-thailand
#18
Juthamas Inchai, Chalerm Liwsrisakun, Chaiwat Bumroongkit, Juntima Eauthrongchit, Pattraporn Tajareunmuang, Chaicharn Pothirat
Tuberculosis (TB) among healthcare workers (HCWs) highly impacts morbidity and TB transmission in hospital. A retrospective cohort study of TB among HCWs (HCW-TB) was conducted using a registered database from 2003 to 2016 at Chiang Mai University Hospital to determine clinical and microbiological characteristics and treatment outcomes of HCW-TB. Seventy-six cases of HCWs, 54 nurses (71.1%), 12 physicians (15.8%) and 10 paramedics (13.2%), were diagnosed with TB disease. Female to male ratio of 51:25, mean age of 37...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29697766/intermediate-susceptibility-dose-dependent-breakpoints-for-high-dose-rifampicin-isoniazid-and-pyrazinamide-treatment-in-multidrug-resistant-tuberculosis-programmes
#19
Marlanka A Zuur, Jotam G Pasipanodya, Dick van Soolingen, Tjip S van der Werf, Tawanda Gumbo, Jan-Willem C Alffenaar
Background: In infectious diseases, for some drugs, bacterial susceptibility is categorized as susceptible, intermediate-susceptible dose-dependent (ISDD), and resistant. The strategy is to use higher doses of first-line agents in the ISDD category, thereby preserving the use of these drugs. This system has not been applied to anti-tuberculosis drugs. Pharmacokinetics/pharmacodynamics (PK/PD) target exposures, in tandem with Monte Carlo experiments (MCE), recently identified susceptibility breakpoints of 0...
April 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29697293/benzothiazole-analogues-as-potential-anti-tb-agents-computational-input-and-molecular-dynamics
#20
Katharigatta N Venugopala, Mohammed A Khedr, Melendhran Pillay, Susanta K Nayak, Sandeep Chandrashekharappa, Bandar E Al Dhubiab, Sree Harsha, Mahesh Attimarad, Bharti Odhav
Biotin is very important for the survival of Mycobacterium tuberculosis. 7,8-Diamino pelargonic acid aminotransaminase (DAPA) is a transaminase enzyme involved in the biosynthesis of biotin. The benzothiazole title compounds were investigated for their in vitro anti-tubercular activity against two tubercular strains: H37Rv (ATCC 25177) and MDR-MTB (multidrug-resistant M. tuberculosis, resistant to isoniazid, rifampicin, and ethambutol) by an agar incorporation method. The possible binding mode and predicted affinity were computed using a molecular docking study...
April 26, 2018: Journal of Biomolecular Structure & Dynamics
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