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multidrug resistant tuberculosis

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https://www.readbyqxmd.com/read/28919720/text-messaging-to-decrease-tuberculosis-treatment-attrition-in-tb-hiv-coinfection-in-uganda
#1
Sabine M Hermans, Sawsan Elbireer, Harriet Tibakabikoba, Bas J Hoefman, Yukari C Manabe
BACKGROUND: Low tuberculosis (TB) treatment completion rates in sub-Saharan Africa are an important driver of multidrug resistance. Mobile technology-based interventions have been shown to improve adherence to antiretroviral therapy in sub-Saharan Africa. We aimed to test the effect of a short-message service (SMS) intervention on loss to follow-up (LFU). MATERIALS AND METHODS: In this quasi-experimental study, all adult, literate, HIV-infected patients with mobile phone access diagnosed with TB between November 2010 and October 2011 in an urban clinic in Uganda were eligible to receive adherence and appointment reminders and educational quizzes during the first 8 weeks of TB treatment...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28911366/lophomonas-blattarum-co-infection-in-a-patient-with-multidrug-resistant-tuberculosis
#2
Chaman Thakur, S Verma, R S Negi, V Kumar, S Gupta, V Sharma
No abstract text is available yet for this article.
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911354/drug-resistance-patterns-among-extra-pulmonary-tuberculosis-cases-in-a-tertiary-care-centre-in-north-india
#3
S K Sharma, J Chaubey, B K Singh, R Sharma, A Mittal, A Sharma
BACKGROUND: xtra-pulmonary tuberculosis (EPTB) is a growing public health concern, and data on drug resistance are limited. MATERIAL AND METHODS: Specimens from 2468 clinically diagnosed EPTB patients received at the Intermediate Reference Laboratory (IRL) of a tertiary centre in India were subjected to Ziehl-Neelsen staining, Xpert® MTB/RIF testing, liquid culture and drug susceptibility testing (DST) using automated BACTEC MGIT™ 960™. Line-probe assay (LPA) was performed on all culture-positive isolates...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911353/persistently-high-early-mortality-despite-rapid-diagnostics-for-drug-resistant-tuberculosis-cases-in-south-africa
#4
K Schnippel, C Firnhaber, N Ndjeka, F Conradie, L Page-Shipp, R Berhanu, E Sinanovic
OBJECTIVE: To describe the timing and predictors of mortality among multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) patients reported in the South African electronic drug-resistant TB register (EDRweb), 2012-2014. DESIGN: We present time-to-event survival analysis and Cox proportional hazards regression. Identity numbers were matched to the National Vital Statistics Register. RESULTS: Of the 20 653 patients included in the analysis (median age 35 years, interquartile range 28-43), over half were male (n = 10 944, 53...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28905529/who-treatment-guidelines-for-drug-resistant-tuberculosis-2016-update-applicability-in-south-korea
#5
REVIEW
Doosoo Jeon
Despite progress made in tuberculosis control worldwide, the disease burden and treatment outcome of multidrug-resistant tuberculosis (MDR-TB) patients have remained virtually unchanged. In 2016, the World Health Organization released new guidelines for the management of MDR-TB. The guidelines are intended to improve detection rate and treatment outcome for MDR-TB through novel, rapid molecular testing and shorter treatment regimens. Key changes include the introduction of a new, shorter MDR-TB treatment regimen, a new classification of medicines and updated recommendations for the conventional MDR-TB regimen...
September 1, 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28904673/mutations-in-rpob-and-katg-genes-of-multidrug-resistant-mycobacterium-tuberculosis-undetectable-using-genotyping-diagnostic-methods
#6
Faustinos Tatenda Takawira, Racheal Shamiso Dube Mandishora, Zephaniah Dhlamini, Ellen Munemo, Babill Stray-Pedersen
INTRODUCTION: Tuberculosis remains the leading causes of death worldwide with frequencies of mutations in rifampicin and isoniazid resistant Mycobacterium tuberculosis isolates varying according to geographical location. There is limited information in Zimbabwe on specific antibiotic resistance gene mutation patterns in MTB and hence, increased rate of discordant results and mortality due to inappropriate antibiotic prescriptions. The rpoB and katG genes molecular markers are used for detecting rifampicin and isoniazid resistance respectively...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904562/proceedings-from-the-cih-lmu-5th-infectious-diseases-symposium-2016-drug-resistant-tuberculosis-old-disease-new-challenge
#7
Celso Khosa, Krutarth Patel, Karlygash Abdiyeva, Nurkeldi Turebekov, Bettina Prüller, Norbert Heinrich
The 5th CIH(LMU) Infectious Disease Symposium, Munich, Germany, March 12, 2016 brought together Tuberculosis Experts from developed and low middle-income countries to discuss the control of drug resistance Tuberculosis. The meeting featured 9 presentations: Tuberculosis history and current scenario, Tuberculosis and migration - current scenario in Germany, Mechanism of Tuberculosis resistance development, Epidemiology of resistance - transmission vs. new generation of resistance, The impact of diagnostic in patients beyond - sensitivity and specificity, The Bangladesh regimen - new hope trough old drugs, New drugs and regimens - an overview on studies and Multi and Extensively Drug Resistant Tuberculosis from Europe...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28902596/evaluation-of-a-rapid-molecular-drug-susceptibility-test-for-tuberculosis
#8
Yingda L Xie, Soumitesh Chakravorty, Derek T Armstrong, Sandra L Hall, Laura E Via, Taeksun Song, Xing Yuan, Xiaoying Mo, Hong Zhu, Peng Xu, Qian Gao, Myungsun Lee, Jongseok Lee, Laura E Smith, Ray Y Chen, Joon Sung Joh, YoungSoo Cho, Xin Liu, Xianglin Ruan, Lili Liang, Nila Dharan, Sang-Nae Cho, Clifton E Barry, Jerrold J Ellner, Susan E Dorman, David Alland
Background Fluoroquinolones and second-line injectable drugs are the backbone of treatment regimens for multidrug-resistant tuberculosis, and resistance to these drugs defines extensively drug-resistant tuberculosis. We assessed the accuracy of an automated, cartridge-based molecular assay for the detection, directly from sputum specimens, of Mycobacterium tuberculosis with resistance to fluoroquinolones, aminoglycosides, and isoniazid. Methods We conducted a prospective diagnostic accuracy study to compare the investigational assay against phenotypic drug-susceptibility testing and DNA sequencing among adults in China and South Korea who had symptoms of tuberculosis...
September 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28893776/mycobacterium-tuberculosis-subculture-results-in-loss-of-potentially-clinically-relevant-heteroresistance
#9
John Z Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E Colman, Renee Penaloza, Christopher Allender, Darrin Lemmer, Robin M Warren, David M Engelthaler
Multidrug-resistant tuberculosis is a major public health dilemma. Heteroresistance, the co-existence of drug-resistant and drug-susceptible strains, or multiple drug-resistant strains with discrete haplotypes, may affect accurate diagnosis and institution of effective treatment. Subculture, or passage of cells onto fresh growth medium, is utilized to preserve M. tuberculosis cell lines and is universally employed in TB diagnostics. The impact of such passages, typically performed in the absence of drug, on drug-resistant subpopulations is hypothesized to vary according to the competitive costs of genotypic resistance-associated variants...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28893611/emerging-peak-on-the-phylogeographic-landscape-of-mycobacterium-tuberculosis-in-west-asia-definitely-smoke-likely-fire
#10
Igor Mokrousov, Egor Shitikov, Yuriy Skiba, Sergey Kolchenko, Ekaterina Chernyaeva, Anna Vyazovaya
To date, a major attention was justly given to the global lineages of Mycobacterium tuberculosis. Here, we demonstrated an importance of the minor ones, on an example of intriguing and underestimated NEW-1 family that belongs to Euro-American lineage (lineage 4). Analysis of the global WGS/NGS datasets (5715 strains) identified 2235 strains of Lineage 4 and 66 strains of sublineage L4.5. This latter is marked with RD122 genomic deletion and includes NEW-1 family. Phylogenomic analysis confirmed a separate position of the NEW-1 family that we tentatively designate L4...
September 8, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28884143/use-of-genotype-mtbdrplus-assay-for-diagnosis-of-multidrug-resistant-tuberculosis-in-nepal
#11
Elina Maharjan, Narayan Dutt Pant, Sanjeev Neupane, Jyoti Amatya, Bhawana Shrestha
The main aims of this study were to study the patterns of mutations in rpoB, katG, and inhA genes in Mycobacterium tuberculosis strains isolated from patients from Nepal and to evaluate the performance of genotype MTBDRplus assay, taking conventional drug susceptibility testing as gold standard for diagnosis of MDR-TB. A total of 69 Mycobacterium tuberculosis strains isolated from 73 smear positive sputum samples from patients suspected of suffering from multidrug-resistant tuberculosis were used in our study...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28883399/antibiotic-treatment-for-tuberculosis-induces-a-profound-dysbiosis-of-the-microbiome-that-persists-long-after-therapy-is-completed
#12
Matthew F Wipperman, Daniel W Fitzgerald, Marc Antoine Jean Juste, Ying Taur, Sivaranjani Namasivayam, Alan Sher, James M Bean, Vanni Bucci, Michael S Glickman
Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world's population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial specific antibiotics, and treatment of multidrug resistant TB is longer. The widespread use of this regimen makes this one of the largest exposures of humans to antimicrobials, yet the effects of TB treatment on intestinal microbiome composition and long-term stability are unknown...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879163/diagnostic-system-strengthening-for-drug-resistant-tuberculosis-in-nigeria-impact-and-challenges
#13
Gambo Aliyu, Nicholas Ezati, Mosunmola Iwakun, Sam Peters, Alash'le Abimiku
BACKGROUND: The increasing prevalence of drug-resistant tuberculosis and the threat of extensively-drug-resistant tuberculosis in HIV hotspots have made the detection and treatment of drug-resistant tuberculosis in the sub-Saharan Africa setting a global public health priority. OBJECTIVE: We sought to examine the impact and challenges of tuberculosis diagnostic capacity development for the detection of drug-resistant tuberculosis and bio-surveillance using a modular biosafety level 3 (BSL-3) laboratory in Nigeria...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28875168/ceftazidime-avibactam-has-potent-sterilizing-activity-against-highly-drug-resistant-tuberculosis
#14
Devyani Deshpande, Shashikant Srivastava, Moti Chapagain, Gesham Magombedze, Katherine R Martin, Kayle N Cirrincione, Pooi S Lee, Thearith Koeuth, Keertan Dheda, Tawanda Gumbo
There are currently many patients with multidrug-resistant and extensively drug-resistant tuberculosis. Ongoing transmission of the highly drug-resistant strains and high mortality despite treatment remain problematic. The current strategy of drug discovery and development takes up to a decade to bring a new drug to clinical use. We embarked on a strategy to screen all antibiotics in current use and examined them for use in tuberculosis. We found that ceftazidime-avibactam, which is already used in the clinic for multidrug-resistant Gram-negative bacillary infections, markedly killed rapidly growing, intracellular, and semidormant Mycobacterium tuberculosis in the hollow fiber system model...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28869400/azide-alkyne-cycloaddition-en-route-to-4-aminoquinoline-ferrocenylchalcone-conjugates-synthesis-and-anti-tb-evaluation
#15
Amandeep Singh, Albertus Viljoen, Laurent Kremer, Vipan Kumar
AIM: Tuberculosis is responsible for 9.6 million infections and 1.5 million deaths in 2015. The development of multidrug-resistant and extensively drug-resistant strains has impeded the development of effective antitubercular therapy. Results/methodology: The present manuscript describes the synthesis of a series of 4-aminoquinoline-ferrocenylchalcone conjugates via Cu-promoted Huisgen's azide-alkyne cycloaddition reaction and evaluation of their antitubercular activities against mc(2)6230 strain of Mycobacterium tuberculosis...
September 4, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28869227/a-study-on-beijing-genotype-in-the-clinical-isolates-of-pulmonary-drug-resistant-tuberculosis
#16
Ankit Kumar, Ajay Kumar Verma, Surya Kant, Ved Prakash, Anand Srivastava, Kanchan Srivastava, Amita Jain, Kishore K Srivastava
BACKGROUND: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). AIM: The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas. MATERIALS AND METHODS: It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28869226/inconsistency-in-the-reporting-of-antitubercular-drug-susceptibility-tests-in-an-endemic-region
#17
Avinandan Saha, Preyas J Vaidya, Vinod B Chavhan, Kamlesh V Pandey, Arvind H Kate, Prashant N Chhajed
BACKGROUND: Individualized treatment for multidrug-resistant tuberculosis (MDR TB) is associated with improved outcomes. Therapy needs to be tailored to drug susceptibility testing (DST) results. We present our observations on the inconsistency in DST reporting in an endemic region with a high prevalence of MDR TB. METHODS: We retrospectively analyzed 118 DST reports from 10 different laboratories. OBSERVATIONS: Of 118 patients, only 79 (67%) had DST reports with results to all first-line drugs, a fluoroquinolone (excluding ciprofloxacin), all aminoglycosides, and a polypeptide...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28858250/solution-nmr-studies-of-mycobacterium-tuberculosis-proteins-for-antibiotic-target-discovery
#18
REVIEW
Do-Hee Kim, Sung-Min Kang, Bong-Jin Lee
Tuberculosis is an infectious disease caused by Mycobacteriumtuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR)...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28856604/in-silico-drug-design-of-thiolactomycin-derivatives-against-mtb-kasa-enzyme-to-inhibit-multidrug-resistance-of-mycobacterium-tuberculosis
#19
D Ruban Durairaj, P Shanmughavel
Tuberculosis (TB) is a leading infectious disease which kills a huge number of people every year over a decade, caused by Mycobacterium tuberculosis. The conventional drugs in the market are no longer effective due to the increasing mycobacterial resistance to antibiotics. Hence, the need of finding efficient drugs to solve this multiple drug resistant factor is becoming an immediate issue. The first-line drugs in current practice for the treatment of TB emphasize on mycolic acid, which protects the bacteria from an immune response generated by the host...
August 30, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28854957/a-systematic-synthesis-of-direct-costs-to-treat-and-manage-tuberculosis-disease-applied-to-california-2015
#20
Peter Oh, Lisa Pascopella, Pennan M Barry, Jennifer M Flood
BACKGROUND: The cost of treating and managing cases of active tuberculosis (TB) disease-from diagnosis to treatment completion-is needed by agencies working on public health budgets, resource allocation and cost-effectiveness analysis. Although components of TB costs have been published in the United States (US), no recent study has assessed overall costs for TB care and potential gaps. To systematically review the US literature for costs of treating and managing cases of active TB disease, adjust these costs to current (2015) values, and assess gaps...
August 30, 2017: BMC Research Notes
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