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Amir Ghaferi

Lindsey A Muir, Nicki A Baker, Alexandra R Washabaugh, Christopher K Neeley, Carmen G Flesher, Jennifer B DelProposto, Lynn M Geletka, Amir A Ghaferi, Jonathan F Finks, Kanakadurga Singer, Oliver A Varban, Carey N Lumeng, Robert W O'Rourke
Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects...
January 27, 2017: Adipocyte
Nicki A Baker, Lindsey A Muir, Alexandra R Washabaugh, Christopher K Neeley, Sophie Yu-Pu Chen, Carmen G Flesher, John Vorwald, Jonathan F Finks, Amir A Ghaferi, Michael W Mulholland, Oliver A Varban, Carey N Lumeng, Robert W O'Rourke
Context: The role of the extracellular matrix (ECM) in regulating adipocyte metabolism in the context of metabolic disease is poorly defined. Objective: The objective of this study was to define the metabolic phenotype of adipocytes associated with human diabetes (DM) and the role of the ECM in regulating adipocyte metabolism. Design: Adipose tissues from obese patients were studied in standard 2-dimensional (2D) cell culture and an in vitro model of decellularized adipose tissue ECM repopulated with human adipocytes, and results were correlated with DM status...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
Hassaan Abdel Khalik, Haley Stevens, Arthur M Carlin, Amanda Stricklen, Rachel Ross, Carl Pesta, Jonathan F Finks, Andrew Ibrahim, Amir A Ghaferi
OBJECTIVE: The aim of this study was to explore the efficacy of current bariatric perioperative measures at reducing emergency department (ED) visits following bariatric surgery in the state of Michigan. SUMMARY OF BACKGROUND DATA: Many ED visits following bariatric surgery do not result in readmission and may be preventable. Little research exists evaluating the efficacy of perioperative measures aimed at reducing ED visits in this population. Therefore, understanding the driving factors behind these preventable ED visits may be a fruitful approach to prevention...
March 16, 2017: Annals of Surgery
Ryan Macht, Ruth Cassidy, Howard Cabral, Lewis E Kazis, Amir Ghaferi
BACKGROUND: Several patient and surgical characteristics have been identified as risk factors for readmission after bariatric surgery, but there is a paucity of information on how organizational factors influence this metric. OBJECTIVE: To evaluate the association between readmissions and several organizational factors, including compliance with best practices to reduce unplanned hospital visits, major complication rates, and the emergency department-sourced readmission (EDSR) rate...
January 2, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Jason C Pradarelli, Mark A Healy, Nicholas H Osborne, Amir A Ghaferi, Justin B Dimick, Hari Nathan
Importance: Treating surgical complications presents a major challenge for hospitals striving to deliver high-quality care while reducing costs. Costs associated with rescuing patients from perioperative complications are poorly characterized. Objective: To evaluate differences across hospitals in the costs of care for patients surviving perioperative complications after major inpatient surgery. Design, Setting, and Participants: Retrospective cohort study using claims data from the Medicare Provider Analysis and Review files...
December 21, 2016: JAMA Surgery
Jennifer F Waljee, Amir Ghaferi, Ruth Cassidy, Oliver Varban, Jonathan Finks, Kevin C Chung, Noelle E Carlozzi, Justin B Dimick
OBJECTIVE: To evaluate the extent to which patient-reported outcomes (PROs) (eg, health-related quality of life) are distinct from clinical outcomes following bariatric surgery. BACKGROUND: Hospital quality measurement often focuses on traditional clinical outcomes (eg, complications). However, PROs may provide a unique perspective regarding performance, particularly for common, low-risk procedures. METHODS: We used data from 11,420 patients who underwent bariatric surgery (2008-2012) from the Michigan Bariatric Surgery Collaborative (39 hospitals)...
October 2016: Annals of Surgery
Andrew M Ibrahim, Amir A Ghaferi, Jyothi R Thumma, Justin B Dimick
OBJECTIVE: To examine the relationship between hospital outcomes and expenditures in patients undergoing bariatric surgery in the United States. BACKGROUND: As one of the most common surgical procedures in the United States, bariatric surgery is a major focus of policy reforms aimed at reducing surgical costs. These policy mechanisms have made it imperative to understand the potential cost savings of quality-improvement initiatives. METHODS: We performed a retrospective review of 38,374 Medicare beneficiaries undergoing bariatric surgery between 2011 and 2013...
September 6, 2016: Annals of Surgery
Oliver A Varban, Caprice C Greenberg, Jon Schram, Amir A Ghaferi, Joythi R Thumma, Arthur M Carlin, Justin B Dimick
BACKGROUND: Recent data establish a strong link between peer video ratings of surgical skill and clinical outcomes with laparoscopic gastric bypass. Whether skill for one bariatric procedure can predict outcomes for another related procedure is unknown. METHODS: Twenty surgeons voluntarily submitted videos of a standard laparoscopic gastric bypass procedure, which was blindly rated by 10 or more peers using a modified version of the Objective Structured Assessment of Technical Skills...
November 2016: Surgery
Amir A Ghaferi, Marilyn Woodruff, Jenna Arnould
No abstract text is available yet for this article.
August 1, 2016: JAMA Surgery
Amir A Ghaferi, Christopher R Friese
No abstract text is available yet for this article.
June 1, 2016: JAMA Surgery
Jason C Pradarelli, Oliver A Varban, Amir A Ghaferi, Matthew Weiner, Arthur M Carlin, Justin B Dimick
BACKGROUND: Laparoscopic sleeve gastrectomy has surpassed gastric bypass and laparoscopic adjustable gastric banding recently as the most common weight-loss procedure. Previously, substantial concerns existed regarding variation in perioperative safety with bariatric surgery. This study aimed to assess rates of perioperative complications for laparoscopic sleeve gastrectomy across hospitals and in relation to procedure volume within the Michigan Bariatric Surgery Collaborative. STUDY DESIGN: We analyzed 8,693 patients who underwent laparoscopic sleeve gastrectomy from 2013 through 2014 across 40 hospitals in the Michigan Bariatric Surgery Collaborative...
April 2016: Surgery
Kyle H Sheetz, Justin B Dimick, Amir A Ghaferi
OBJECTIVE: To determine the effect of hospital characteristics on failure to rescue after high-risk surgery in Medicare beneficiaries. SUMMARY BACKGROUND DATA: Reducing failure to rescue events is a common quality target for US hospitals. Little is known about which hospital characteristics influence this phenomenon and more importantly by how much. METHODS: We identified 1,945,802 Medicare beneficiaries undergoing 1 of six high-risk general or vascular operations between 2007 and 2010...
April 2016: Annals of Surgery
Myura Nagendran, Justin B Dimick, Andrew A Gonzalez, John D Birkmeyer, Amir A Ghaferi
BACKGROUND: A large body of research suggests that hospitals with intensive care units staffed by board-certified intensivists have lower mortality rates than those that do not. OBJECTIVE: To determine whether hospitals can reduce their mortality by adopting an intensivist staffing model. DESIGN: Retrospective, longitudinal study using 2003-2010 Medicare data and the Leapfrog Group Hospital surveys. SETTING AND PATIENTS: In total, 2,916,801 Medicare patients at 488 US hospitals...
January 2016: Medical Care
Jennifer F Waljee, Amir Ghaferi, Jonathan F Finks, Ruth Cassidy, Oliver Varban, Arthur Carlin, Noelle Carlozzi, Justin Dimick
BACKGROUND: Although there is growing interest in applying patient-reported outcomes (PROs) toward surgical quality, the extent to which PROs vary across hospitals following surgical procedures is unknown. OBJECTIVES: We examined variation in PROs, specifically health-related quality of life (HRQOL), across hospitals performing bariatric surgery. RESEARCH DESIGN: A retrospective cohort study. SUBJECTS: The Michigan Bariatric Surgery Collaborative is a statewide consortium of 39 hospitals performing laparoscopic gastric bypass, gastric banding, or sleeve gastrectomy (n=11,420 patients between 2008 and 2012)...
November 2015: Medical Care
Amir A Ghaferi, Carol Lindsay-Westphal
No abstract text is available yet for this article.
March 2016: JAMA Surgery
Christopher R Friese, Rong Xia, Amir Ghaferi, John D Birkmeyer, Mousumi Banerjee
Hospital executives pursue external recognition to improve market share and demonstrate institutional commitment to quality of care. The Magnet Recognition Program of the American Nurses Credentialing Center identifies hospitals that epitomize nursing excellence, but it is not clear that receiving Magnet recognition improves patient outcomes. Using Medicare data on patients hospitalized for coronary artery bypass graft surgery, colectomy, or lower extremity bypass in 1998-2010, we compared rates of risk-adjusted thirty-day mortality and failure to rescue (death after a postoperative complication) between Magnet and non-Magnet hospitals matched on hospital characteristics...
June 2015: Health Affairs
Justin B Dimick, Amir A Ghaferi
No abstract text is available yet for this article.
February 3, 2015: JAMA: the Journal of the American Medical Association
Amir A Ghaferi, Justin B Dimick
No abstract text is available yet for this article.
May 2015: Annals of Surgery
Kyle H Sheetz, Justin B Dimick, Amir A Ghaferi
IMPORTANCE: Hospitals' care intensity varies widely across the United States. Payers and policy makers have become focused on promoting quality, low-cost, efficient health care. OBJECTIVE: To evaluate whether increased hospital care intensity (HCI) is associated with improved outcomes following major surgery. DESIGN, SETTING, AND PARTICIPANTS: Using national Medicare data in this retrospective cohort study, we identified 706,520 patients at 2544 hospitals who underwent 1 of 7 major cardiovascular, orthopedic, or general surgical operations...
December 2014: JAMA Surgery
Andrew A Gonzalez, Zaid M Abdelsattar, Justin B Dimick, Shantanu Dev, John D Birkmeyer, Amir A Ghaferi
OBJECTIVES: To determine if mortality varies by time-to-readmission (TTR). BACKGROUND: Although readmissions reduction is a national health care priority, little progress has been made toward understanding why only some readmissions lead to adverse outcomes. METHODS: In this retrospective cross-sectional cohort analysis, we used 2005-2009 Medicare data on beneficiaries undergoing colectomy, lung resection, or coronary artery bypass grafting (n = 1,033,255) to created 5 TTR groups: no 30-day readmission (n = 897,510), less than 6 days (n = 44,361), 6 to 10 days (n = 31,018), 11 to 15 days (n = 20,797), 16 to 20 days (n = 15,483), or more than 21 days (n = 24,086)...
July 2015: Annals of Surgery
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