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https://www.readbyqxmd.com/read/29673386/risk-factors-and-short-term-outcomes-of-postoperative-pulmonary-complications-after-vats-lobectomy
#1
Paula J Agostini, Sebastian T Lugg, Kerry Adams, Tom Smith, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
BACKGROUND: Postoperative pulmonary complications (PPCs) are associated with poor outcomes following thoracotomy and lung resection. Video-assisted thoracoscopic surgery (VATS) for lobectomy is now frequently utilised as an alternative to thoracotomy, however patients remain at risk for development of PPC. There is little known of the short-term outcome associated with PPC following VATS lobectomy and if there are any potential risk factors that could be modified to prevent PPC development; our study aimed to investigate this...
April 12, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29666623/autoimmunity-to-tropomyosin-specific-peptides-induced-by-mycobacterium-leprae-in-leprosy-patients-identification-of-mimicking-proteins
#2
Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D Gupta, Utpal Sengupta
Background: It has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in all types of leprosy patients and their associations in type 1 reaction (T1R) group of leprosy. Objectives: In this study, we investigated the association of levels of autoantibodies and lymphoproliferation against myosin in leprosy patients across the spectrum and tried to find out the mimicking proteins or epitopes between host protein and protein/s of Mycobacterium leprae ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29625978/subgroup-characteristics-of-marine-methane-oxidizing-anme-2-archaea-and-their-syntrophic-partners-revealed-by-integrated-multimodal-analytical-microscopy
#3
Shawn E McGlynn, Grayson L Chadwick, Ariel O'Neill, Mason Mackey, Andrea Thor, Thomas J Deerinck, Mark H Ellisman, Victoria J Orphan
Phylogenetically diverse environmental ANME archaea and sulfate-reducing bacteria cooperatively catalyze the anaerobic oxidation of methane oxidation (AOM) in multi-celled consortia within methane seep environments. To better understand these cells and their symbiotic associations, we applied a suite of electron microscopy approaches including correlative<u>f</u>luorescence <u>i</u> n<u>s</u>itu <u>h</u>ybridization -<u>e</u>lectron<u>m</u>icroscopy (FISH-EM),<u>t</u>ransmission<u>e</u>lectron<u>m</u>icroscopy (TEM), and<u>s</u>erial<u>b</u>lock face scanning<u>e</u>lectron<u>m</u>icroscopy 3D reconstructions (SBEM)...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29601130/halogen-aromatic-%C3%AF-interactions-modulate-inhibitor-residence-time
#4
Christina Heroven, Victoria Georgi, Gaurav K Ganotra, Paul E Brennan, Finn Wolfreys, Rebecca C Wade, Amaury E Fernández-Montalván, Apirat Chaikuad, Stefan Knapp
Prolonged drug residence times may result in longer lasting drug efficacy, improved pharmacodynamic properties and "kinetic selectivity" over off-targets with fast drug dissociation rates. However, few strategies have been elaborated to rationally modulate drug residence time and thereby to integrate this key property into the drug development process. Here, we show that the interaction between a halogen moiety on an inhibitor and an aromatic residue in the target protein can significantly increase inhibitor residence time...
March 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29577793/can-we-predict-levator-ani-muscle-avulsion-in-instrumental-deliveries-through-intrapartum-transperineal-ultrasound
#5
José Antonio García-Mejido, Paloma de la Fuente, Adriana Aquise, Laura Castro, Ana Fernández-Palacín, José Antonio Sainz
INTRODUCTION: To determine whether intrapartum translabial ultrasound (ITU) is useful for the prediction of levator ani muscle (LAM) avulsions in instrumental deliveries (vacuum, forceps). MATERIAL AND METHODS: Prospective, observational study, including (1/2016 - 5/2016) 77 nulliparous women, with singleton pregnancies of ≥ 37 weeks of gestation and with cephalic presentation, who required vacuum or forceps instrumentation to complete the delivery. The ITU parameters evaluated were: Angle of Progression (AoP), Progression Distance (PD), Head Direction (HD) and Midline Angle (MLA), both at rest and with maternal push...
March 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29529977/routine-ct-scanning-of-patients-retrieved-to-a-tertiary-centre-on-veno-venous-extracorporeal-membrane-oxygenation-a-retrospective-risk-benefit-analysis
#6
Kate M Richmond, Katharine G Warburton, Simon J Finney, Sachin Shah, Benjamin A J Reddi
INTRODUCTION: Comprehensive clinical examination can be compromised in patients on veno-venous extracorporeal membrane oxygenation (VV-ECMO). Adjunctive diagnostic imaging strategies range from bedside imaging only to routine computed tomography (CT). The risk-benefit of either approach remains to be evaluated. Patients retrieved to the Royal Brompton Hospital (RBH) on VV-ECMO routinely undergo admission CT imaging of head, chest, abdomen and pelvis. This study aimed to identify how frequently changes in therapy or adverse events could be attributed to routine CT scanning...
March 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29517322/self-rostering-can-improve-work-life-balance-and-staff-retention-in-the-nhs
#7
Renee Barrett, Annie Holme
Renee Barrett, Staff Nurse, ITU, Great Ormond Street Hospital NHS Trust, renee.barrett@gosh.nhs.uk , and Annie Holme, Lecturer, King's College London, look at how e-rostering can benefit health organisations and staff.
March 8, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29499362/anaemia-in-patients-with-chronic-liver-disease-and-its-association-with-morbidity-and-mortality-following-liver-transplantation
#8
Oliver Collas, Francis P Robertson, Barry J Fuller, Brian R Davidson
Pre-operative anaemia and the need for intra-operative transfusion have been associated with increased morbidity and mortality following cardiac and major non-cardiac surgery. Anaemia is highly prevalent in patients with severe chronic liver disease. Whether this correlates with an altered morbidity and mortality following liver transplant has not been established. METHODS: Prospectively collected data was analysed for the period 1998-2012. Donor and recipient characteristics, blood profiles and complications were recorded...
February 27, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29494609/a-modified-artificial-neural-network-based-prediction-technique-for-tropospheric-radio-refractivity
#9
Shumaila Javeed, Khurram Saleem Alimgeer, Wajahat Javed, M Atif, Mueen Uddin
Radio refractivity plays a significant role in the development and design of radio systems for attaining the best level of performance. Refractivity in the troposphere is one of the features affecting electromagnetic waves, and hence the communication system interrupts. In this work, a modified artificial neural network (ANN) based model is applied to predict the refractivity. The suggested ANN model comprises three modules: the data preparation module, the feature selection module, and the forecast module...
2018: PloS One
https://www.readbyqxmd.com/read/29416362/enriched-whole-genome-sequencing-identified-compensatory-mutations-in-the-rna-polymerase-gene-of-rifampicin-resistant-mycobacterium-leprae-strains
#10
Mallika Lavania, Itu Singh, Ravindra P Turankar, Anuj Kumar Gupta, Madhvi Ahuja, Vinay Pathak, Utpal Sengupta
Despite more than three decades of multidrug therapy (MDT), leprosy remains a major public health issue in several endemic countries, including India. The emergence of drug resistance in Mycobacterium leprae (M. leprae) is a cause of concern and poses a threat to the leprosy-control program, which might ultimately dampen the achievement of the elimination program of the country. Rifampicin resistance in clinical strains of M. leprae are supposed to arise from harboring bacterial strains with mutations in the 81-bp rifampicin resistance determining region (RRDR) of the rpoB gene...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29373159/single-ended-prediction-of-listening-effort-using-deep-neural-networks
#11
Rainer Huber, Melanie Krüger, Bernd T Meyer
The effort required to listen to and understand noisy speech is an important factor in the evaluation of noise reduction schemes. This paper introduces a model for Listening Effort prediction from Acoustic Parameters (LEAP). The model is based on methods from automatic speech recognition, specifically on performance measures that quantify the degradation of phoneme posteriorgrams produced by a deep neural net: Noise or artifacts introduced by speech enhancement often result in a temporal smearing of phoneme representations, which is measured by comparison of phoneme vectors...
December 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/29343086/percutaneous-nephrolithotomy-and-spina-bifida-complex-major-stone-surgery
#12
Stephen Mitchell, Pratik Gurung, Simon Choong, Timothy Morris, Daron Smith, Christopher Woodhouse, Timothy Philp
Background The incidence of spina bifida (SB) is approx 1:1000, and risk of stone disease is substantially raised in SB. This is the unique published study of the outcome of patients with SB undergoing percutaneous nephrolithotomy (PCNL) compared to a neurologically intact historically matched control group at the same institution. Patients and Method A series of 96 PCNLs in 13 SB and 50 non-SB control patients was analysed. The following measurements were recorded: (1) Co-morbidities; (2) Pre-operative: (renal function, American Society of Anesthesiologists (ASA) score); (3) Intra-operative: (anaesthesia time, number of tracks, stone free rate) and (4) Post-operative: (sepsis, intensive therapy unit (ITU) and total length of stay, transfusion rate, stone composition, rate of stone disease-related nephrectomy)...
January 17, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29326184/assessing-the-effectiveness-of-a-patient-centred-computer-based-clinic-intervention-health-e-you-salud-itu-to-reduce-health-disparities-in-unintended-pregnancies-among-hispanic-adolescents-study-protocol-for-a-cluster-randomised-control-trial
#13
Kathleen P Tebb, Felicia Rodriguez, Lance M Pollack, Sang Leng Trieu, Loris Hwang, Maryjane Puffer, Sally Adams, Elizabeth M Ozer, Claire D Brindis
INTRODUCTION: Teen pregnancy rates in the USA remain higher than any other industrialised nation, and pregnancies among Hispanic adolescents are disproportionately high. Computer-based interventions represent a promising approach to address sexual health and contraceptive use disparities. Preliminary findings have demonstrated that the Health-E You/Salud iTu, computer application (app) is feasible to implement, acceptable to Latina adolescents and improves sexual health knowledge and interest in selecting an effective contraceptive method when used in conjunction with a healthcare visit...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29313500/m-diabete-in-senegal-be-he-lthy-be-mobile-a-program-initiated-by-who-and-the-itu
#14
H Eskandar, S Pujari, I-K Dia, L Kleinebreil, S Meagher
The health-care systems of Africa must adapt to the exponential progression of nontransmissible diseases, diabetes in particular. How can we accelerate population awareness of the risk factors? How can we provide the minimal education necessary to all people with diabetes to limit its complications? The "Be He@lthy Be Mobile" initiative of WHO and the ITU (International Telecommunications Union) and its "m-Diabete" app in Senegal explore the conditions for establishing a large-scale patient-education program using texting and its potential health impact...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29305343/health-information-technology-usability-evaluation-scale-health-itues-for-usability-assessment-of-mobile-health-technology-validation-study
#15
Rebecca Schnall, Hwayoung Cho, Jianfang Liu
BACKGROUND: Mobile technology has become a ubiquitous technology and can be particularly useful in the delivery of health interventions. This technology can allow us to deliver interventions to scale, cover broad geographic areas, and deliver technologies in highly tailored ways based on the preferences or characteristics of users. The broad use of mobile technologies supports the need for usability assessments of these tools. Although there have been a number of usability assessment instruments developed, none have been validated for use with mobile technologies...
January 5, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29285343/non-invasive-assessment-of-patient-specific-aortic-haemodynamics-from-four-dimensional-flow-mri-data
#16
Lucian Itu, Dominik Neumann, Viorel Mihalef, Felix Meister, Martin Kramer, Mehmet Gulsun, Marcus Kelm, Titus Kühne, Puneet Sharma
We introduce a parameter estimation framework for automatically and robustly personalizing aortic haemodynamic computations from four-dimensional magnetic resonance imaging data. The framework is based on a reduced-order multiscale fluid-structure interaction blood flow model, and on two calibration procedures. First, Windkessel parameters of the outlet boundary conditions are personalized by solving a system of nonlinear equations. Second, the regional mechanical wall properties of the aorta are personalized by employing a nonlinear least-squares minimization method...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29240700/high-speed-video-system-for-micro-expression-detection-and-recognition
#17
Diana Borza, Radu Danescu, Razvan Itu, Adrian Darabant
Micro-expressions play an essential part in understanding non-verbal communication and deceit detection. They are involuntary, brief facial movements that are shown when a person is trying to conceal something. Automatic analysis of micro-expression is challenging due to their low amplitude and to their short duration (they occur as fast as 1/15 to 1/25 of a second). We propose a fully micro-expression analysis system consisting of a high-speed image acquisition setup and a software framework which can detect the frames when the micro-expressions occurred as well as determine the type of the emerged expression...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29201628/aluminum-doped-cesium-lead-bromide-perovskite-nanocrystals-with-stable-blue-photoluminescence-used-for-display-backlight
#18
Ming Liu, Guohua Zhong, Yongming Yin, Jingsheng Miao, Ke Li, Chengqun Wang, Xiuru Xu, Clifton Shen, Hong Meng
Bright and stable blue emitters with narrow full-width at half-maxima are particularly desirable for applications in television displays and related technologies. Here, this study shows that doping aluminum (Al3+ ) ion into CsPbBr3 nanocrystals (NCs) using AlBr3 can afford lead-halide perovskites NCs with stable blue photoluminescence. First, theoretical and experimental analyses reveal that the extended band gap and quantum confinement effect of elongated shape give rise to the desirable blueshifted emission...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29182799/inhaled-magnesium-sulfate-in-the-treatment-of-acute-asthma
#19
REVIEW
Rachel Knightly, Stephen J Milan, Rodney Hughes, Jennifer A Knopp-Sihota, Brian H Rowe, Rebecca Normansell, Colin Powell
BACKGROUND: Asthma exacerbations can be frequent and range in severity from mild to life-threatening. The use of magnesium sulfate (MgSO₄) is one of numerous treatment options available during acute exacerbations. While the efficacy of intravenous MgSO₄ has been demonstrated, the role of inhaled MgSO₄ is less clear. OBJECTIVES: To determine the efficacy and safety of inhaled MgSO₄ administered in acute asthma. SPECIFIC AIMS: to quantify the effects of inhaled MgSO₄ I) in addition to combination treatment with inhaled β₂-agonist and ipratropium bromide; ii) in addition to inhaled β₂-agonist; and iii) in comparison to inhaled β₂-agonist...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29176904/mobile-microscopy-as-a-screening-tool-for-oral-cancer-in-india-a-pilot-study
#20
Arunan Skandarajah, Sumsum P Sunny, Praveen Gurpur, Clay D Reber, Michael V D'Ambrosio, Nisheena Raghavan, Bonney Lee James, Ravindra D Ramanjinappa, Amritha Suresh, Uma Kandasarma, Praveen Birur, Vinay V Kumar, Honorius-Cezar Galmeanu, Alexandru Mihail Itu, Mihai Modiga-Arsu, Saskia Rausch, Maria Sramek, Manohar Kollegal, Gianluca Paladini, Moni Kuriakose, Lance Ladic, Felix Koch, Daniel Fletcher
Oral cancer is the most common type of cancer among men in India and other countries in South Asia. Late diagnosis contributes significantly to this mortality, highlighting the need for effective and specific point-of-care diagnostic tools. The same regions with high prevalence of oral cancer have seen extensive growth in mobile phone infrastructure, which enables widespread access to telemedicine services. In this work, we describe the evaluation of an automated tablet-based mobile microscope as an adjunct for telemedicine-based oral cancer screening in India...
2017: PloS One
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