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https://www.readbyqxmd.com/read/29416362/enriched-whole-genome-sequencing-identified-compensatory-mutations-in-the-rna-polymerase-gene-of-rifampicin-resistant-mycobacterium-leprae-strains
#1
Mallika Lavania, Itu Singh, Ravindra P Turankar, Anuj Kumar Gupta, Madhvi Ahuja, Vinay Pathak, Utpal Sengupta
Despite more than three decades of multidrug therapy (MDT), leprosy remains a major public health issue in several endemic countries, including India. The emergence of drug resistance in Mycobacterium leprae (M. leprae) is a cause of concern and poses a threat to the leprosy-control program, which might ultimately dampen the achievement of the elimination program of the country. Rifampicin resistance in clinical strains of M. leprae are supposed to arise from harboring bacterial strains with mutations in the 81-bp rifampicin resistance determining region (RRDR) of the rpoB gene...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29373159/single-ended-prediction-of-listening-effort-using-deep-neural-networks
#2
Rainer Huber, Melanie Krüger, Bernd T Meyer
The effort required to listen to and understand noisy speech is an important factor in the evaluation of noise reduction schemes. This paper introduces a model for Listening Effort prediction from Acoustic Parameters (LEAP). The model is based on methods from automatic speech recognition, specifically on performance measures that quantify the degradation of phoneme posteriorgrams produced by a deep neural net: Noise or artifacts introduced by speech enhancement often result in a temporal smearing of phoneme representations, which is measured by comparison of phoneme vectors...
December 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/29343086/percutaneous-nephrolithotomy-and-spina-bifida-complex-major-stone-surgery
#3
Stephen Mitchell, Pratik Gurung, Simon Choong, Timothy Morris, Daron Smith, Christopher Woodhouse, Timothy Philp
Background The incidence of spina bifida (SB) is approx 1:1000, and risk of stone disease is substantially raised in SB. This is the unique published study of the outcome of patients with SB undergoing percutaneous nephrolithotomy (PCNL) compared to a neurologically intact historically matched control group at the same institution. Patients and Method A series of 96 PCNLs in 13 SB and 50 non-SB control patients was analysed. The following measurements were recorded: (1) Co-morbidities; (2) Pre-operative: (renal function, American Society of Anesthesiologists (ASA) score); (3) Intra-operative: (anaesthesia time, number of tracks, stone free rate) and (4) Post-operative: (sepsis, intensive therapy unit (ITU) and total length of stay, transfusion rate, stone composition, rate of stone disease-related nephrectomy)...
January 17, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29326184/assessing-the-effectiveness-of-a-patient-centred-computer-based-clinic-intervention-health-e-you-salud-itu-to-reduce-health-disparities-in-unintended-pregnancies-among-hispanic-adolescents-study-protocol-for-a-cluster-randomised-control-trial
#4
Kathleen P Tebb, Felicia Rodriguez, Lance M Pollack, Sang Leng Trieu, Loris Hwang, Maryjane Puffer, Sally Adams, Elizabeth M Ozer, Claire D Brindis
INTRODUCTION: Teen pregnancy rates in the USA remain higher than any other industrialised nation, and pregnancies among Hispanic adolescents are disproportionately high. Computer-based interventions represent a promising approach to address sexual health and contraceptive use disparities. Preliminary findings have demonstrated that the Health-E You/Salud iTu, computer application (app) is feasible to implement, acceptable to Latina adolescents and improves sexual health knowledge and interest in selecting an effective contraceptive method when used in conjunction with a healthcare visit...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29313500/m-diabete-in-senegal-be-he-lthy-be-mobile-a-program-initiated-by-who-and-the-itu
#5
H Eskandar, S Pujari, I-K Dia, L Kleinebreil, S Meagher
The health-care systems of Africa must adapt to the exponential progression of nontransmissible diseases, diabetes in particular. How can we accelerate population awareness of the risk factors? How can we provide the minimal education necessary to all people with diabetes to limit its complications? The "Be He@lthy Be Mobile" initiative of WHO and the ITU (International Telecommunications Union) and its "m-Diabete" app in Senegal explore the conditions for establishing a large-scale patient-education program using texting and its potential health impact...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29305343/health-information-technology-usability-evaluation-scale-health-itues-for-usability-assessment-of-mobile-health-technology-validation-study
#6
Rebecca Schnall, Hwayoung Cho, Jianfang Liu
BACKGROUND: Mobile technology has become a ubiquitous technology and can be particularly useful in the delivery of health interventions. This technology can allow us to deliver interventions to scale, cover broad geographic areas, and deliver technologies in highly tailored ways based on the preferences or characteristics of users. The broad use of mobile technologies supports the need for usability assessments of these tools. Although there have been a number of usability assessment instruments developed, none have been validated for use with mobile technologies...
January 5, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29285343/non-invasive-assessment-of-patient-specific-aortic-haemodynamics-from-four-dimensional-flow-mri-data
#7
Lucian Itu, Dominik Neumann, Viorel Mihalef, Felix Meister, Martin Kramer, Mehmet Gulsun, Marcus Kelm, Titus Kühne, Puneet Sharma
We introduce a parameter estimation framework for automatically and robustly personalizing aortic haemodynamic computations from four-dimensional magnetic resonance imaging data. The framework is based on a reduced-order multiscale fluid-structure interaction blood flow model, and on two calibration procedures. First, Windkessel parameters of the outlet boundary conditions are personalized by solving a system of nonlinear equations. Second, the regional mechanical wall properties of the aorta are personalized by employing a nonlinear least-squares minimization method...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29240700/high-speed-video-system-for-micro-expression-detection-and-recognition
#8
Diana Borza, Radu Danescu, Razvan Itu, Adrian Darabant
Micro-expressions play an essential part in understanding non-verbal communication and deceit detection. They are involuntary, brief facial movements that are shown when a person is trying to conceal something. Automatic analysis of micro-expression is challenging due to their low amplitude and to their short duration (they occur as fast as 1/15 to 1/25 of a second). We propose a fully micro-expression analysis system consisting of a high-speed image acquisition setup and a software framework which can detect the frames when the micro-expressions occurred as well as determine the type of the emerged expression...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29201628/aluminum-doped-cesium-lead-bromide-perovskite-nanocrystals-with-stable-blue-photoluminescence-used-for-display-backlight
#9
Ming Liu, Guohua Zhong, Yongming Yin, Jingsheng Miao, Ke Li, Chengqun Wang, Xiuru Xu, Clifton Shen, Hong Meng
Bright and stable blue emitters with narrow full-width at half-maxima are particularly desirable for applications in television displays and related technologies. Here, this study shows that doping aluminum (Al3+) ion into CsPbBr3 nanocrystals (NCs) using AlBr3 can afford lead-halide perovskites NCs with stable blue photoluminescence. First, theoretical and experimental analyses reveal that the extended band gap and quantum confinement effect of elongated shape give rise to the desirable blueshifted emission...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29182799/inhaled-magnesium-sulfate-in-the-treatment-of-acute-asthma
#10
REVIEW
Rachel Knightly, Stephen J Milan, Rodney Hughes, Jennifer A Knopp-Sihota, Brian H Rowe, Rebecca Normansell, Colin Powell
BACKGROUND: Asthma exacerbations can be frequent and range in severity from mild to life-threatening. The use of magnesium sulfate (MgSO₄) is one of numerous treatment options available during acute exacerbations. While the efficacy of intravenous MgSO₄ has been demonstrated, the role of inhaled MgSO₄ is less clear. OBJECTIVES: To determine the efficacy and safety of inhaled MgSO₄ administered in acute asthma. SPECIFIC AIMS: to quantify the effects of inhaled MgSO₄ I) in addition to combination treatment with inhaled β₂-agonist and ipratropium bromide; ii) in addition to inhaled β₂-agonist; and iii) in comparison to inhaled β₂-agonist...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29176904/mobile-microscopy-as-a-screening-tool-for-oral-cancer-in-india-a-pilot-study
#11
Arunan Skandarajah, Sumsum P Sunny, Praveen Gurpur, Clay D Reber, Michael V D'Ambrosio, Nisheena Raghavan, Bonney Lee James, Ravindra D Ramanjinappa, Amritha Suresh, Uma Kandasarma, Praveen Birur, Vinay V Kumar, Honorius-Cezar Galmeanu, Alexandru Mihail Itu, Mihai Modiga-Arsu, Saskia Rausch, Maria Sramek, Manohar Kollegal, Gianluca Paladini, Moni Kuriakose, Lance Ladic, Felix Koch, Daniel Fletcher
Oral cancer is the most common type of cancer among men in India and other countries in South Asia. Late diagnosis contributes significantly to this mortality, highlighting the need for effective and specific point-of-care diagnostic tools. The same regions with high prevalence of oral cancer have seen extensive growth in mobile phone infrastructure, which enables widespread access to telemedicine services. In this work, we describe the evaluation of an automated tablet-based mobile microscope as an adjunct for telemedicine-based oral cancer screening in India...
2017: PloS One
https://www.readbyqxmd.com/read/29169905/fully-laparoscopic-left-hepatectomy-a-technical-reference-proposed-for-standard-practice-compared-to-the-open-approach-a-retrospective-propensity-score-model
#12
Roberto Valente, Robert Sutcliffe, Eric Levesque, Mara Costa, Nicola De' Angelis, Claude Tayar, Daniel Cherqui, Alexis Laurent
BACKGROUND: Laparoscopic left hemihepatectomy (LLH) may be an alternative to open (OLH). There are several original variations in the technical aspects of LLH, and no accepted standard. The aim of this study is to assess the safety and effectiveness of the technique developed at Henri Mondor Hospital since 1996. METHODS: The technique of LLH was conceived for safety and training of two mature generations of lead surgeons. The technique includes full laparoscopy, ventral approach to the common trunk, extrahepatic pedicle dissection, CUSA® parenchymal transection, division of the left hilar plate laterally to the Arantius ligament, and ventral transection of the left hepatic vein...
November 20, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29098002/serum-ferritin-a-backstage-weapon-in-diagnosis-of-dengue-fever
#13
Soumyabrata Roy Chaudhuri, Subhayan Bhattacharya, Mainak Chakraborty, Kingshuk Bhattacharjee
Aims: This retrospective study evaluates ferritin as a surrogate marker for dengue infection (NS1 and IgM negative stage) as opposed to other febrile illnesses of infective or inflammatory etiology (OFI). Methodology: Data of all patients admitted to medical ward and medical ITU during the dengue outbreak were collected. Patients admitted between 5 and 10 days of febrile illness without a diagnosis were included. Patients with NS1 positivity (Days 2-8) and/or positive IgM for dengue (Days 6-10) were considered to be dengue cases and those with other confirmed diagnoses were considered in the OFI group...
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/29097343/molecular-detection-of-multi-drug-resistant-mycobacterium-leprae-from-indian-leprosy-patients
#14
Mallika Lavania, Itu Singh, Ravindra P Turankar, Madhvi Ahuja, Vinay Pathak, Utpal Sengupta, Loretta Das, Archana Kumar, Joydeepa Darlong, Rajeev Nathan, Asha Maseey
OBJECTIVE: Emergence of multi drug resistant (MDR) organism for any infectious disease is a public health concern. Global efforts to control leprosy by intensive chemotherapy have led to a significant decrease in the number of registered patients. Currently recommended control measures for treating leprosy with MDT was designed to prevent the spread of dapsone resistant strains of Mycobacterium leprae. We report here the identification of MDR strains of M. leprae from relapsed leprosy patients from endemic regions in India...
October 30, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29092237/on-chip-free-beam-optics-on-a-polymer-based-photonic-integration-platform
#15
M Happach, D de Felipe, H Conradi, V N Friedhoff, E Schwartz, M Kleinert, W Brinker, C Zawadzki, N Keil, W Hofmann, M Schell
This paper presents on-chip free beam optics on polymer-based photonic components. Due to the circumstance that waveguide-based optics allows no direct beam access we use Gradient index (GRIN) lenses assembled into the chip to collimate the beam from the waveguides. This enables low loss power transmission over a length of 1432 µm. Even though the beam propagates through air it is possible to create a resonator with a wavelength shift of 0.002 nm/°C, hence the allowed deviations from the ITU-T grid (100 GHz) are met for ± 20 °C...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29073638/intratumoural-pd-l1-expression-is-associated-with-worse-survival-of-patients-with-epstein-barr-virus-associated-gastric-cancer
#16
An Na Seo, Byung Woog Kang, Oh Kyoung Kwon, Ki Bum Park, Seung Soo Lee, Ho Young Chung, Wansik Yu, Han Ik Bae, Seong Woo Jeon, Hyojeung Kang, Jong Gwang Kim
BACKGROUND: This study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (PD-L1) and programmed cell death protein ligand-2 (PD-L2), in patients with Epstein-Barr virus-associated gastric cancer (EBVaGC). METHODS: After reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, the expression status of PD-L1 and PD-L2 in 120 patients with EBVaGC identified by EBV-encoded RNA in situ hybridisation was retrospectively analysed using immunohistochemistry (IHC)...
December 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29060372/wearable-internet-of-things-from-human-activity-tracking-to-clinical-integration
#17
Poonam Kumari, Miguel Lopez-Benitez, Gyu Myoung Lee, Tae-Seong Kim, Atul S Minhas
Wearable devices for human activity tracking have been emerging rapidly. Most of them are capable of sending health statistics to smartphones, smartwatches or smart bands. However, they only provide the data for individual analysis and their data is not integrated into clinical practice. Leveraging on the Internet of Things (IoT), edge and cloud computing technologies, we propose an architecture which is capable of providing cloud based clinical services using human activity data. Such services could supplement the shortage of staff in primary healthcare centers thereby reducing the burden on healthcare service providers...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042090/the-natural-history-of-flail-chest-injuries
#18
Kamil Naidoo, Layth Hanbali, Peter Bates
PURPOSE: Flail chest (FC) injuries represent a significant burden on trauma services because of its high morbidity and mortality. Current gold standard conservative management strategies for FC, are now being challenged by renewed interest in surgical rib fixation. This retrospective epidemiological study sets out to evaluate FC patients, and quantify the natural history of this injury by studying the injury patterns, epidemiology and mortality of patients sustaining FC injuries admitted to a major trauma centre (MTC)...
October 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29022481/intra-and-interobserver-variability-of-intrapartum-transperineal-ultrasound-measurements-with-contraction-and-pushing
#19
José A Sainz, Ana Fernández-Palacín, Carlota Borrero, Adriana Aquise, Zenaida Ramos, José A García-Mejido
The aim of this study was to evaluate the inter- and intraobserver correlation of the different intrapartum-transperineal-ultrasound-parameters(ITU) (angle of progression (AoP), progression-distance (PD), head-direction (HD), midline-angle (MLA) and head-perineum distance (HPD)) with contraction and pushing. We evaluated 28 nulliparous women at full dilatation under epidural analgesia. We performed a transperineal ultrasound evaluating AoP and PD in the longitudinal plane, and MLA and HPD in the transverse plane...
October 12, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29021897/patient-outcome-of-emergency-laparotomy-improved-with-increasing-number-of-surgeons-on-call-in-a-university-hospital-audit-loop
#20
Anwar Hussain, Fahad Mahmood, Chui Teng, Sadaf Jafferbhoy, David Luke, Achilleas Tsiamis
AIM: Emergency laparotomy is a commonly performed high-mortality surgical procedure. The National Emergency Laparotomy Network (NELA) published an average mortality rate of 11.1% and a median length of stay equivalent to 16.3 days in patients undergoing emergency laparotomy. This study presents a completed audit loop after implementing the change of increasing the number of on-call surgeons in the general surgery rota of a university hospital. The aim of this study was to evaluate the outcomes of emergency laparotomy in a single UK tertiary centre after addition of one more consultant in the daily on-call rota...
November 2017: Annals of Medicine and Surgery
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