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Jecko Thachil, Theodore E Warkentin
A low platelet count is a frequently encountered haematological abnormality in patients treated in intensive treatment units (ITUs). Although severe thrombocytopenia (platelet count <20 × 10(9) /l) can be associated with bleeding, even moderate-degree thrombocytopenia is associated with organ failure and adverse prognosis. The aetiology for thrombocytopenia in ITU is often multifactorial and correcting one aetiology may not normalise the low platelet count. The classical view for thrombocytopenia in this setting is consumption associated with thrombin-mediated platelet activation, but other concepts, including platelet adhesion to endothelial cells and leucocytes, platelet aggregation by increased von Willebrand factor release, red cell damage and histone release, and platelet destruction by the complement system, have recently been described...
December 16, 2016: British Journal of Haematology
Lucian Calmac, Rodica Niculescu, Elisabeta Badila, Emma Weiss, Daniela Penes, Diana Zamfir, Lucian Itu, Laszlo Lazar, Marius Carp, Alexandru Itu, Constantin Suciu, Tiziano Passerini, Puneet Sharma, Bogdan Georgescu, Dorin Comaniciu
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
Jure Tuta, Matjaz B Juric
This paper presents a novel method for indoor localization, developed with the main aim of making it useful for real-world deployments. Many indoor localization methods exist, yet they have several disadvantages in real-world deployments-some are static, which is not suitable for long-term usage; some require costly human recalibration procedures; and others require special hardware such as Wi-Fi anchors and transponders. Our method is self-calibrating and self-adaptive thus maintenance free and based on Wi-Fi only...
December 6, 2016: Sensors
Amar Bhat, Maryam Asghar, Gagandeep Raulia, Amit Keiran John Mandal
Each year in the UK, it is estimated that more than 100,000 people are admitted to hospital with sepsis and around 37,000 people will die as a result of the condition. We present an audit, re-audit and the implications these have had on the management of severe sepsis using the Sepsis Six, ultimately through actively promoting teamwork to initiate the protocol. This led to a significant improvement in management, decreasing admissions to the intensive care unit (ITU), length of stay in hospital and the number of patient deaths...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
Hamid Moghaddasi, Samad Sajjadi, Mehran Kamkarhaghighi
INTRODUCTION: Any information which is generated and saved needs to be protected against accidental or intentional losses and manipulations if it is to be used by the intended users in due time. As such, information managers have adopted numerous measures to achieve data security within data storage systems, along with the spread of information technology. BACKGROUND: The "data security models" presented thus far have unanimously highlighted the significance of data security management...
2016: Open Medical Informatics Journal
Miyuki Muramoto, Kiyotake Ichizuka, Junichi Hasegawa, Masamitsu Nakamura, Satoshi Dohi, Hiroshi Saito, Masaaki Nagatsuka
PURPOSE: To clarify whether intrapartum transperineal ultrasound (ITU) can be used to evaluate uterine contraction intensity, and whether the intensity is associated with the duration of the second stage. METHODS: A prospective observational study was performed involving 86 women with a normal singleton term fetus and more than three contractions every 10 min. ITU was performed for contractile and non-contractile periods of labor at the beginning of the second stage, and one representative "angle of progression (AoP)" image was selected for each period...
November 10, 2016: Journal of Medical Ultrasonics
Patrick P Iannone, Alan H Gnauck
We demonstrate distributed Raman amplification compatible with the wavelength plans and rates defined in ITU's specification for TWDM PON. We report downstream and upstream gains of 9.8 dB and 8.6dB, respectively, for a 42-km, 8-wavelength TWDM PON with 80-Gb/s symmetric capacity and 1:128 split. Raman gain and system performance are also reported for 21-km and 10-km feeder lengths.
October 31, 2016: Optics Express
Radu Danescu, Razvan Itu, Andra Petrovai
The driving environment is complex and dynamic, and the attention of the driver is continuously challenged, therefore computer based assistance achieved by processing image and sensor data may increase traffic safety. While active sensors and stereovision have the advantage of obtaining 3D data directly, monocular vision is easy to set up, and can benefit from the increasing computational power of smart mobile devices, and from the fact that almost all of them come with an embedded camera. Several driving assistance application are available for mobile devices, but they are mostly targeted for simple scenarios and a limited range of obstacle shapes and poses...
October 17, 2016: Sensors
Satendra Pal Singh, Minseuk Kim, Woon Bae Park, Jin-Woong Lee, Kee-Sun Sohn
A solid-state combinatorial chemistry approach, which used the A-Ge-O (A = Li, K, Rb) system doped with a small amount of Mn(4+) as an activator, was adopted in a search for novel red-emitting phosphors. The A site may have been composed of either a single alkali metal ion or of a combination of them. This approach led to the discovery of a novel phosphor in the above system with the chemical formula Li3RbGe8O18:Mn(4+). The crystal structure of this novel phosphor was solved via direct methods, and subsequent Rietveld refinement revealed a trigonal structure in the P3̅1m space group...
October 17, 2016: Inorganic Chemistry
Carla Olmo, Amparo Marco, Xavier Armengol, Raquel Ortells
The toxicity of Bacillus thuringiensis var. israelensis on zooplanktonic microcrustaceans was evaluated using individuals collected in coastal wetlands where this larvicide has been used for mosquito control over the last decades. We tested five zooplankton species that coexist with mosquito larvae: two copepods (both nauplii and adults of Tropocyclops prasinus and Acantocyclops americanus), and three cladocerans (Ceriodaphnia reticulata, Chydorus sphaericus, and Daphnia cf. pulex). Our experiments included seven replicates of six concentrations (Bti Vectobac12AS 1200 Bti ITU/mg): 0, 5, 25, 50, 250, and 500 mg L(-1)...
December 2016: Ecotoxicology
Thomas C Hall, Dilraj K Bilku, Christopher P Neal, Jill Cooke, Helena L Fisk, Philip C Calder, Ashley R Dennison
BACKGROUND: Death from sepsis in the intensive therapy unit (ITU) is frequently preceded by the development of multiple organ failure as a result of uncontrolled inflammation. Treatment with omega-3 (n-3) fatty acids (FAs), principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been demonstrated to attenuate the effects of uncontrolled inflammation and may be clinically beneficial in reducing mortality from organ dysfunction. Fish oil (FO) is a source of EPA and DHA...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Weixia Gao, Fenghong Liu, Wei Zhang, Yufen Quan, Yulei Dang, Jun Feng, Yanyan Gu, Shufang Wang, Cunjiang Song, Chao Yang
Poly-γ-glutamic acid (γ-PGA) is an important natural biopolymer that is used widely in fields of foods, medicine, cosmetics, and agriculture. Several B. amyloliquefaciens LL3 mutants were constructed to improve γ-PGA synthesis via single or multiple marker-less in-frame deletions of four gene clusters (itu, bae, srf, and fen) encoding antibiotic substances. γ-PGA synthesis by the Δsrf mutant showed a slight increase (4.1 g/L) compared with that of the wild-type strain (3.3 g/L). The ΔituΔsrf mutant showed increased γ-PGA yield from 3...
August 18, 2016: MicrobiologyOpen
N D Ritchie, S C Irvine, A Helps, F Robb, B L Jones, R A Seaton
INTRODUCTION: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam antibiotics and promotion of agents associated with a lower risk of CDI such as gentamicin. While the introduction of restrictive antibiotic guidance has been associated with improvements in CDI and antimicrobial resistance, evidence of the effect on outcome following severe infection is lacking...
August 13, 2016: QJM: Monthly Journal of the Association of Physicians
Munjal M Acharya, Janet E Baulch, Theresa A Lusardi, Barrett D Allen, Nicole N Chmielewski, Al Anoud D Baddour, Charles L Limoli, Detlev Boison
Clinical radiation therapy for the treatment of CNS cancers leads to unintended and debilitating impairments in cognition. Radiation-induced cognitive dysfunction is long lasting; however, the underlying molecular and cellular mechanisms are still not well established. Since ionizing radiation causes microglial and astroglial activation, we hypothesized that maladaptive changes in astrocyte function might be implicated in radiation-induced cognitive dysfunction. Among other gliotransmitters, astrocytes control the availability of adenosine, an endogenous neuroprotectant and modulator of cognition, via metabolic clearance through adenosine kinase (ADK)...
2016: Frontiers in Molecular Neuroscience
Ahsan Rao, Amna Suliman, Sabine Vuik, Paul Aylin, Ara Darzi
INTRODUCTION: Aim of the study was to compare various outcomes of dementia patients with elderly patients without dementia by conducting a systematic review of previous population-based studies. METHODS: The relevant studies were retrieved from search of electronic databases. RESULTS: The pooled data from included 11 studies consisted of outcomes of 1,044,131 dementia patients compared to 9,639,027 elderly patients without dementia. Meta-analysis showed that the mortality in dementia patients was 15...
September 2016: Archives of Gerontology and Geriatrics
D Bendel, H Gardner, M Outram
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Geon Koh, Kyung Hoon Hwang, Haejun Lee, Seog Gyun Kim, Beom Koo Lee
PURPOSE: To determine whether treatment response in patients with knee pain could be predicted using uptake patterns on single-photon emission computed tomography/computed tomography (SPECT/CT) images. METHODS: Ninety-five patients with knee pain who had undergone SPECT/CT were included in this retrospective study. Subjects were divided into three groups: increased focal uptake (FTU), increased irregular tracer uptake (ITU), and no tracer uptake (NTU). A numeric rating scale (NRS-11) assessed pain intensity...
June 2016: Nuclear Medicine and Molecular Imaging
Nathaniel T Berry, Laurie Wideman, Edgar W Shields, Claudio L Battaglini
Multisport events continue to grow in popularity among recreational, amateur, and professional athletes around the world. This study aimed to determine the compounding effects of the initial run and cycling legs of an International Triathlon Union (ITU) Duathlon simulation on maximal oxygen uptake (VO2max), ventilatory threshold (VT) and running economy (RE) within a thermoneutral, laboratory controlled setting. Seven highly trained multisport athletes completed three trials; Trial-1 consisted of a speed only VO2max treadmill protocol (SOVO2max) to determine VO2max, VT, and RE during a single-bout run; Trial-2 consisted of a 10 km run at 98% of VT followed by an incremental VO2max test on the cycle ergometer; Trial-3 consisted of a 10 km run and 30 km cycling bout at 98% of VT followed by a speed only treadmill test to determine the compounding effects of the initial legs of a duathlon on VO2max, VT, and RE...
June 2016: Journal of Sports Science & Medicine
Itu Singh, Mallika Lavania, Astha Nigam, Ravindra P Turankar, Madhvi Ahuja, Annamma S John, Utpal Sengupta
No abstract text is available yet for this article.
March 2016: Leprosy Review
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