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Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
Hamid Moghaddasi, Samad Sajjadi, Mehran Kamkarhaghighi
INTRODUCTION: Any information which is generated and saved needs to be protected against accidental or intentional losses and manipulations if it is to be used by the intended users in due time. As such, information managers have adopted numerous measures to achieve data security within data storage systems, along with the spread of information technology. BACKGROUND: The "data security models" presented thus far have unanimously highlighted the significance of data security management...
2016: Open Medical Informatics Journal
Miyuki Muramoto, Kiyotake Ichizuka, Junichi Hasegawa, Masamitsu Nakamura, Satoshi Dohi, Hiroshi Saito, Masaaki Nagatsuka
PURPOSE: To clarify whether intrapartum transperineal ultrasound (ITU) can be used to evaluate uterine contraction intensity, and whether the intensity is associated with the duration of the second stage. METHODS: A prospective observational study was performed involving 86 women with a normal singleton term fetus and more than three contractions every 10 min. ITU was performed for contractile and non-contractile periods of labor at the beginning of the second stage, and one representative "angle of progression (AoP)" image was selected for each period...
November 10, 2016: Journal of Medical Ultrasonics
Patrick P Iannone, Alan H Gnauck
We demonstrate distributed Raman amplification compatible with the wavelength plans and rates defined in ITU's specification for TWDM PON. We report downstream and upstream gains of 9.8 dB and 8.6dB, respectively, for a 42-km, 8-wavelength TWDM PON with 80-Gb/s symmetric capacity and 1:128 split. Raman gain and system performance are also reported for 21-km and 10-km feeder lengths.
October 31, 2016: Optics Express
Radu Danescu, Razvan Itu, Andra Petrovai
The driving environment is complex and dynamic, and the attention of the driver is continuously challenged, therefore computer based assistance achieved by processing image and sensor data may increase traffic safety. While active sensors and stereovision have the advantage of obtaining 3D data directly, monocular vision is easy to set up, and can benefit from the increasing computational power of smart mobile devices, and from the fact that almost all of them come with an embedded camera. Several driving assistance application are available for mobile devices, but they are mostly targeted for simple scenarios and a limited range of obstacle shapes and poses...
October 17, 2016: Sensors
Satendra Pal Singh, Minseuk Kim, Woon Bae Park, Jin-Woong Lee, Kee-Sun Sohn
A solid-state combinatorial chemistry approach, which used the A-Ge-O (A = Li, K, Rb) system doped with a small amount of Mn(4+) as an activator, was adopted in a search for novel red-emitting phosphors. The A site may have been composed of either a single alkali metal ion or of a combination of them. This approach led to the discovery of a novel phosphor in the above system with the chemical formula Li3RbGe8O18:Mn(4+). The crystal structure of this novel phosphor was solved via direct methods, and subsequent Rietveld refinement revealed a trigonal structure in the P3̅1m space group...
October 17, 2016: Inorganic Chemistry
Carla Olmo, Amparo Marco, Xavier Armengol, Raquel Ortells
The toxicity of Bacillus thuringiensis var. israelensis on zooplanktonic microcrustaceans was evaluated using individuals collected in coastal wetlands where this larvicide has been used for mosquito control over the last decades. We tested five zooplankton species that coexist with mosquito larvae: two copepods (both nauplii and adults of Tropocyclops prasinus and Acantocyclops americanus), and three cladocerans (Ceriodaphnia reticulata, Chydorus sphaericus, and Daphnia cf. pulex). Our experiments included seven replicates of six concentrations (Bti Vectobac12AS 1200 Bti ITU/mg): 0, 5, 25, 50, 250, and 500 mg L(-1)...
September 17, 2016: Ecotoxicology
Thomas C Hall, Dilraj K Bilku, Christopher P Neal, Jill Cooke, Helena L Fisk, Philip C Calder, Ashley R Dennison
BACKGROUND: Death from sepsis in the intensive therapy unit (ITU) is frequently preceded by the development of multiple organ failure as a result of uncontrolled inflammation. Treatment with omega-3 (n-3) fatty acids (FAs), principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been demonstrated to attenuate the effects of uncontrolled inflammation and may be clinically beneficial in reducing mortality from organ dysfunction. Fish oil (FO) is a source of EPA and DHA...
September 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Weixia Gao, Fenghong Liu, Wei Zhang, Yufen Quan, Yulei Dang, Jun Feng, Yanyan Gu, Shufang Wang, Cunjiang Song, Chao Yang
Poly-γ-glutamic acid (γ-PGA) is an important natural biopolymer that is used widely in fields of foods, medicine, cosmetics, and agriculture. Several B. amyloliquefaciens LL3 mutants were constructed to improve γ-PGA synthesis via single or multiple marker-less in-frame deletions of four gene clusters (itu, bae, srf, and fen) encoding antibiotic substances. γ-PGA synthesis by the Δsrf mutant showed a slight increase (4.1 g/L) compared with that of the wild-type strain (3.3 g/L). The ΔituΔsrf mutant showed increased γ-PGA yield from 3...
August 18, 2016: MicrobiologyOpen
Neil D Ritchie, Sharon C Irvine, Helps Alieen, Robb Fiona, Brian L Jones, R Andrew Seaton
INTRODUCTION: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam antibiotics and promotion of agents associated with a lower risk of CDI such as gentamicin. Whilst the introduction of restrictive antibiotic guidance has been associated with improvements in CDI and antimicrobial resistance evidence of the effect on outcome following severe infection is lacking...
August 13, 2016: QJM: Monthly Journal of the Association of Physicians
Munjal M Acharya, Janet E Baulch, Theresa A Lusardi, Barrett D Allen, Nicole N Chmielewski, Al Anoud D Baddour, Charles L Limoli, Detlev Boison
Clinical radiation therapy for the treatment of CNS cancers leads to unintended and debilitating impairments in cognition. Radiation-induced cognitive dysfunction is long lasting; however, the underlying molecular and cellular mechanisms are still not well established. Since ionizing radiation causes microglial and astroglial activation, we hypothesized that maladaptive changes in astrocyte function might be implicated in radiation-induced cognitive dysfunction. Among other gliotransmitters, astrocytes control the availability of adenosine, an endogenous neuroprotectant and modulator of cognition, via metabolic clearance through adenosine kinase (ADK)...
2016: Frontiers in Molecular Neuroscience
Ahsan Rao, Amna Suliman, Sabine Vuik, Paul Aylin, Ara Darzi
INTRODUCTION: Aim of the study was to compare various outcomes of dementia patients with elderly patients without dementia by conducting a systematic review of previous population-based studies. METHODS: The relevant studies were retrieved from search of electronic databases. RESULTS: The pooled data from included 11 studies consisted of outcomes of 1,044,131 dementia patients compared to 9,639,027 elderly patients without dementia. Meta-analysis showed that the mortality in dementia patients was 15...
September 2016: Archives of Gerontology and Geriatrics
D Bendel, H Gardner, M Outram
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Geon Koh, Kyung Hoon Hwang, Haejun Lee, Seog Gyun Kim, Beom Koo Lee
PURPOSE: To determine whether treatment response in patients with knee pain could be predicted using uptake patterns on single-photon emission computed tomography/computed tomography (SPECT/CT) images. METHODS: Ninety-five patients with knee pain who had undergone SPECT/CT were included in this retrospective study. Subjects were divided into three groups: increased focal uptake (FTU), increased irregular tracer uptake (ITU), and no tracer uptake (NTU). A numeric rating scale (NRS-11) assessed pain intensity...
June 2016: Nuclear Medicine and Molecular Imaging
Nathaniel T Berry, Laurie Wideman, Edgar W Shields, Claudio L Battaglini
Multisport events continue to grow in popularity among recreational, amateur, and professional athletes around the world. This study aimed to determine the compounding effects of the initial run and cycling legs of an International Triathlon Union (ITU) Duathlon simulation on maximal oxygen uptake (VO2max), ventilatory threshold (VT) and running economy (RE) within a thermoneutral, laboratory controlled setting. Seven highly trained multisport athletes completed three trials; Trial-1 consisted of a speed only VO2max treadmill protocol (SOVO2max) to determine VO2max, VT, and RE during a single-bout run; Trial-2 consisted of a 10 km run at 98% of VT followed by an incremental VO2max test on the cycle ergometer; Trial-3 consisted of a 10 km run and 30 km cycling bout at 98% of VT followed by a speed only treadmill test to determine the compounding effects of the initial legs of a duathlon on VO2max, VT, and RE...
June 2016: Journal of Sports Science & Medicine
Itu Singh, Mallika Lavania, Astha Nigam, Ravindra P Turankar, Madhvi Ahuja, Annamma S John, Utpal Sengupta
No abstract text is available yet for this article.
March 2016: Leprosy Review
Mallika Lavania, Abu Hena, Hasanoor Reja, Astha Nigam, Nibir Kumar Biswas, Itu Singh, Ravindra P Turankar, Ud Gupta, Senthil Kumar, Latika Rewaria, Pradip K R Patra, Utpal Sengupta, Basudeb Bhattacharya
BACKGROUND: Rifampicin is the major drug in the treatment of leprosy. The rifampicin resistance of Mycobacterium leprae results from a mutation in the rpoB gene, encoding the β subunit of RNA polymerase. As M. leprae is a non-cultivable organism observation of its growth using mouse food-pad (MFP) is the only Gold Standard assay used for confirmation of "in-vivo" drug resistance. OBJECTIVE: Any mutation at molecular level has to be verified by MFP assay for final confirmation of drug resistance in leprosy...
March 2016: Leprosy Review
Lucian Itu, Puneet Sharma, Constantin Suciu, Florin Moldoveanu, Dorin Comaniciu
We propose a hierarchical parameter estimation framework for performing patient-specific hemodynamic computations in arterial models which use structured tree boundary conditions. A calibration problem is formulated at each stage of the hierarchical framework, which seeks the fixed point solution of a nonlinear system of equations. Common hemodynamic properties, like resistance and compliance, are estimated at the first stage in order to match the objectives given by clinical measurements of pressure and/or flow rate...
May 18, 2016: International Journal for Numerical Methods in Biomedical Engineering
Dominik Neumann, Tommaso Mansi, Lucian Itu, Bogdan Georgescu, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Ali Amr, Jan Haas, Hugo Katus, Benjamin Meder, Stefan Steidl, Joachim Hornegger, Dorin Comaniciu
Personalization is the process of fitting a model to patient data, a critical step towards application of multi-physics computational models in clinical practice. Designing robust personalization algorithms is often a tedious, time-consuming, model- and data-specific process. We propose to use artificial intelligence concepts to learn this task, inspired by how human experts manually perform it. The problem is reformulated in terms of reinforcement learning. In an off-line phase, Vito, our self-taught artificial agent, learns a representative decision process model through exploration of the computational model: it learns how the model behaves under change of parameters...
April 21, 2016: Medical Image Analysis
J L Gálvez San Román, C Jiménez Hidalgo, M M Portillo Cano, M O García Sánchez, C Navarro Bustos, A Julián-Jiménez, M Martínez Ortiz de Zárate, J González del Castillo
BACKGROUND: The aim of this paper is to determine both the prevalence of urinary tract infection (UTI) in the emergency department (ED) and the most relevant epidemiological changes in the last decade, as well as the profile and management of these patients. METHODS: Descriptive cross-sectional analysis at 49 Spanish ED during 12 months. All patients with infections and UTI diagnosis were included. All patients attended to in ED during the study were recorded as well...
2016: Anales del Sistema Sanitario de Navarra
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