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https://www.readbyqxmd.com/read/28647723/a-retrospective-cohort-study-of-high-impact-users-among-patients-with-cerebrovascular-conditions
#1
Ahsan Rao, Alice Jones, Alex Bottle, Ara Darzi, Paul Aylin
OBJECTIVE: To apply group-based trajectory modelling (GBTM) to the hospital administrative data to evaluate, model and visualise trends and changes in the frequency of long-term hospital care use of the subgroups of patients with cerebrovascular conditions. DESIGN: A retrospective cohort study of patients with cerebrovascular conditions. SETTINGS: Secondary care of all patients with cerebrovascular conditions admitted to English National Hospital Service hospitals...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28629433/smoking-and-timing-of-cessation-on-postoperative-pulmonary-complications-after-curative-intent-lung-cancer-surgery
#2
Sebastian T Lugg, Theofano Tikka, Paula J Agostini, Amy Kerr, Kerry Adams, Maninder S Kalkat, Richard S Steyn, Pala B Rajesh, Ehab Bishay, David R Thickett, Babu Naidu
BACKGROUND: Smoking is a risk factor for postoperative pulmonary complications (PPC) following non-small cell lung cancer (NSCLC) surgery. The optimal timing for preoperative smoking cessation has not been identified. Our study aimed to observe the impact of preoperative smoking cessation on PPC incidence and other postoperative outcomes including long-term survival. METHODS: A prospective study included consecutive patients following resection for NSCLC in a regional thoracic centre over a 4-year period (2010-2014)...
June 19, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28628968/performance-trends-in-age-group-triathletes-in-the-olympic-distance-triathlon-at-the-world-championships-2009-2014
#3
Martin Wonerow, Christoph Alexander Rüst, Pantelis Theodoros Nikolaidis, Thomas Rosemann, Beat Knechtle
Performance trends in elite triathletes competing in age group classes have been investigated for Ironman triathlon in ‘Ironman Hawaii’ but not for short distance triathletes competing at international level in events such as the Olympic distance triathlon at the World Championships. The aim of the present study was to evaluate participation and performance trends of age group triathletes competing in the Olympic distance triathlon at the International Triathlon Union (ITU) World Championships 2009-2014...
June 30, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28562077/medical-student-perceptions-of-clinical-neurosurgery-teaching-in-an-undergraduate-medical-school-curriculum
#4
James Knight, Lauren Stroud, Thomas Geyton, Anthony Stead, Hannah R Cock
AIM: The aim of this study was to evaluate undergraduate medical student perceptions as to the value of different types of neurosurgical teaching to their general neuroscience education, delivered in the penultimate year of a U.K medical school. METHODS: We surveyed penultimate-year medical students at St George's Hospital Medical School, University of London (SGUL), who were undertaking their clinical neuroscience attachment from August 2014 to July 2015. A questionnaire comprising closed Likert scale questions and an open question inviting participants to comment freely was used to assess student perception about the value of Neurosurgical sessions within their overall neuroscience education...
May 31, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28501815/can-the-prehospital-national-early-warning-score-identify-patients-most-at-risk-from-subsequent-deterioration
#5
Joanna Shaw, Rachael T Fothergill, Sophie Clark, Fionna Moore
INTRODUCTION: The National Early Warning Score (NEWS) aids the early recognition of those at risk of becoming critically ill. NEWS has been recommended for use by ambulance services, but very little work has been undertaken to date to determine its suitability. This paper examines whether a prehospital NEWS derived from ambulance service clinical observations is associated with the hospital ED disposition. METHODS: Prehospital NEWS was retrospectively calculated from the ambulance service clinical records of 287 patients who were treated by the ambulance service and transported to hospital...
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28490285/a-comparative-study-of-short-term-outcomes-of-colorectal-cancer-surgery-in-the-elderly-population
#6
Clarence Yen, Constantinos Simillis, Mariam Choudhry, Sarah Mills, Oliver Warren, Paris P Tekkis, Christos Kontovounisios
BACKGROUND: Colorectal Cancer (CRC) is a disease of the elderly, and with an ageing population, oncological surgical procedures for CRC in the elderly is expected to increase. However, the balance between surgical benefits and risks associated with age and comorbidities in elderly patients is obscure. MATERIALS AND METHODS: A retrospective database of consecutive patients who received CRC surgery was used to compare short-term surgical and oncological outcomes between patients aged ≥75 and <75 years old undergoing CRC resection...
May 11, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28460211/controversies-about-cervical-cancer-screening-a-qualitative-study-of-roma-women-s-non-participation-in-cervical-cancer-screening-in-romania
#7
Trude Andreassen, Elisabete Weiderpass, Florian Nicula, Ofelia Suteu, Andreea Itu, Minodora Bumbu, Aida Tincu, Giske Ursin, Kåre Moen
Romania has Europe's highest incidence and mortality of cervical cancer. While a free national cervical cancer-screening programme has been in operation since 2012, participation in the programme is low, particularly in minority populations. The aim of this study was to explore Roma women's (non)participation in the programme from women's own perspectives and those of healthcare providers and policy makers. We carried out fieldwork for a period of 125 days in 2015/16 involving 144 study participants in Cluj and Bucharest counties...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28439965/identifying-signatures-of-positive-selection-in-pigmentation-genes-in-two-south-asian-populations
#8
Manjari Jonnalagadda, Neeraj Bharti, Yatish Patil, Shantanu Ozarkar, Sunitha Manjari K, Rajendra Joshi, Heather Norton
OBJECTIVES: Skin pigmentation is a polygenic trait showing wide phenotypic variations among global populations. While numerous pigmentation genes have been identified to be under positive selection among European and East populations, genes contributing to phenotypic variation in skin pigmentation within and among South Asian populations are still poorly understood. The present study uses data from the Phase 3 of the 1000 genomes project focusing on two South Asian populations-GIH (Gujarati Indian from Houston, Texas) and ITU (Indian Telugu from UK), so as to decode the genetic architecture involved in adaptation to ultraviolet radiation in South Asian populations...
April 24, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28372117/automatic-loudness-control-in-short-form-content-for-broadcasting
#9
Leandro da S Pires, Maurílio N Vieira, Hani C Yehia
During the early years of the International Telecommunication Union (ITU) loudness calculation standard for sound broadcasting [ITU-R (2006), Rec. BS Series, 1770], the need for additional loudness descriptors to evaluate short-form content, such as commercials and live inserts, was identified. This work proposes a loudness control scheme to prevent loudness jumps, which can bother audiences. It employs short-form content audio detection and dynamic range processing methods for the maximum loudness level criteria...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28329213/postoperative-pulmonary-complications-and-rehabilitation-requirements-following-lobectomy-a-propensity-score-matched-study-of-patients-undergoing-video-assisted-thoracoscopic-surgery-versus-thoracotomy%C3%A2
#10
Paula Agostini, Sebastian T Lugg, Kerry Adams, Nelia Vartsaba, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
OBJECTIVES: : Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open thoracotomy due to its minimally invasive approach and associated benefits. However, the effects of the VATS approach on postoperative pulmonary complications (PPC), rehabilitation and physiotherapy requirements are unclear; our study aimed to use propensity score matching to investigate this. METHODS: Between January 2012 and January 2016 all consecutive patients undergoing lobectomy via thoracotomy or VATS were prospectively observed...
June 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28221665/totally-percutaneous-versus-surgical-cut-down-femoral-artery-access-for-elective-bifurcated-abdominal-endovascular-aneurysm-repair
#11
REVIEW
Madelaine Gimzewska, Alexander Ir Jackson, Su Ern Yeoh, Mike Clarke
BACKGROUND: Abdominal aortic aneurysms (AAAs) are a vascular condition with significant risk attached, particularly if they rupture. It is, therefore, critical to identify and repair these as an elective procedure before they rupture and require emergency surgery. Repair has traditionally been an open surgical technique that required a large incision across the abdomen. Endovascular abdominal aortic aneurysm repairs (EVARs) are now a common alternative. In this procedure, the common femoral artery is exposed via a cut-down approach and a graft introduced to the aneurysm in this way...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28220780/bacterial-infections-change-natural-history-of-cirrhosis-irrespective-of-liver-disease-severity
#12
Elena Dionigi, Matteo Garcovich, Mauro Borzio, Gioacchino Leandro, Avik Majumdar, Aikaterini Tsami, Vasiliki Arvaniti, Davide Roccarina, Massimo Pinzani, Andrew K Burroughs, James O'Beirne, Emmanuel A Tsochatzis
OBJECTIVES: We assessed the prognostic significance of infections in relation to current prognostic scores and explored if infection could be considered per se a distinct clinical stage in the natural history of cirrhosis. METHODS: We included consecutive patients with cirrhosis admitted to a tertiary referral liver unit for at least 48 h over a 2-year period. Diagnosis of infection was based on positive cultures or strict established criteria. We used competing risk analysis and propensity score matching for data analysis...
April 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28187033/prognostic-significance-of-stromal-versus-intratumoral-infiltrating-lymphocytes-in-different-subtypes-of-breast-cancer-treated-with-cytotoxic-neoadjuvant-chemotherapy
#13
Thaer Khoury, Vidya Nagrale, Mateusz Opyrchal, Xuan Peng, Dan Wang, Song Yao
BACKGROUND: The aim of the study was to investigate if there were differences in associations of stromal versus intratumoral tumor infiltrating lymphocytes (TILs) with pathology complete response (pCR) among breast cancer (BC) subtypes treated with neoadjuvant therapy. MATERIALS AND METHODS: The hematoxylin and eosin slides of BC-core biopsy consecutive cases (n=331) were reviewed from a single institution between 2000 and 2014. TIL-stroma (TIL-str) was scored from 0% to 100%...
February 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28149251/a-major-burn-injury-in-a-liver-transplant-patient
#14
I Delikonstantinou, B Philp, D Kamel, D Barnes, P Dziewulski
Immunosuppressive therapy may aggravate the clinical course of a burned patient, primarily affecting wound healing and thus complicating permanent wound coverage. We hereby present the successful management of a 48-year-old female liver transplant recipient with a major burn injury, aiming to elucidate the effects of the patient's immunosuppression on surgical treatment. After admission to the Burns ITU, the patient underwent serial debridement of the burn and coverage with cryopreserved allografts. Despite immunosuppression, no prolonged survival of the allo-epidermis was documented...
September 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28112001/comparison-of-single-microphone-noise-reduction-schemes-can-hearing-impaired-listeners-tell-the-difference
#15
Rainer Huber, Thomas Bisitz, Timo Gerkmann, Jürgen Kiessling, Hartmut Meister, Birger Kollmeier
OBJECTIVE: The perceived qualities of nine different single-microphone noise reduction (SMNR) algorithms were to be evaluated and compared in subjective listening tests with normal hearing and hearing impaired (HI) listeners. DESIGN: Speech samples added with traffic noise or with party noise were processed by the SMNR algorithms. Subjects rated the amount of speech distortions, intrusiveness of background noise, listening effort and overall quality, using a simplified MUSHRA (ITU-R, 2003 ) assessment method...
January 23, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/27982413/how-do-we-approach-thrombocytopenia-in-critically-ill-patients
#16
REVIEW
Jecko Thachil, Theodore E Warkentin
A low platelet count is a frequently encountered haematological abnormality in patients treated in intensive treatment units (ITUs). Although severe thrombocytopenia (platelet count <20 × 10(9) /l) can be associated with bleeding, even moderate-degree thrombocytopenia is associated with organ failure and adverse prognosis. The aetiology for thrombocytopenia in ITU is often multifactorial and correcting one aetiology may not normalise the low platelet count. The classical view for thrombocytopenia in this setting is consumption associated with thrombin-mediated platelet activation, but other concepts, including platelet adhesion to endothelial cells and leucocytes, platelet aggregation by increased von Willebrand factor release, red cell damage and histone release, and platelet destruction by the complement system, have recently been described...
April 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/27969893/tct-527-a-data-driven-approach-combining-image-based-anatomical-features-and-resting-state-measurements-for-the-functional-assessment-of-coronary-artery-disease
#17
Lucian Calmac, Rodica Niculescu, Elisabeta Badila, Emma Weiss, Daniela Penes, Diana Zamfir, Lucian Itu, Laszlo Lazar, Marius Carp, Alexandru Itu, Constantin Suciu, Tiziano Passerini, Puneet Sharma, Bogdan Georgescu, Dorin Comaniciu
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27929453/a-self-adaptive-model-based-wi-fi-indoor-localization-method
#18
Jure Tuta, Matjaz B Juric
This paper presents a novel method for indoor localization, developed with the main aim of making it useful for real-world deployments. Many indoor localization methods exist, yet they have several disadvantages in real-world deployments-some are static, which is not suitable for long-term usage; some require costly human recalibration procedures; and others require special hardware such as Wi-Fi anchors and transponders. Our method is self-calibrating and self-adaptive thus maintenance free and based on Wi-Fi only...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27927811/improving-multidisciplinary-severe-sepsis-management-using-the-sepsis-six%C3%A2
#19
Amar Bhat, Maryam Asghar, Gagandeep Raulia, Amit Keiran John Mandal
Each year in the UK, it is estimated that more than 100,000 people are admitted to hospital with sepsis and around 37,000 people will die as a result of the condition. We present an audit, re-audit and the implications these have had on the management of severe sepsis using the Sepsis Six, ultimately through actively promoting teamwork to initiate the protocol. This led to a significant improvement in management, decreasing admissions to the intensive care unit (ITU), length of stay in hospital and the number of patient deaths...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27897967/an-observational-study-of-donor-ex-vivo-lung-perfusion-in-uk-lung-transplantation-develop-uk
#20
Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
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