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Amber Kempton, Matt Cefalu, Cody Justice, Tesla Baich, Mohamed Derbala, Benjamin Canan, Paul M L Janssen, Peter J Mohler, Sakima A Smith
Background: Left ventricular assist devices (LVADs) have revolutionized and improved the care of the sickest heart failure (HF) patients, and it is imperative that they receive appropriate ventricular unloading. Assessing this critical parameter with current methodologies (labs, imaging) is usually suboptimal in this patient population. Hence it is imperative to elucidate the molecular underpinnings involved in ventricular unloading. We have previously identified the cytoskeletal protein βII spectrin as an essential nodal protein involved in post-translational targeting and βII spectrin protein levels are significantly altered in multiple forms of human and animal HF...
January 2018: Heliyon
Jill Alexander, Jim Richards, Obed Attah, Sam Cheema, Joanna Snook, Chloe Wisdell, Karen May, James Selfe
Delayed effects of a 20-min crushed ice application on knee joint position sense assessed by a functional task during a re-warming period. INTRODUCTION: The effect of cryotherapy on joint positioning presents conflicting debates as to whether individuals are at an increased risk of injury when returning to play following cryotherapy application at the lower limb. OBJECTIVES: The aim of this study was to investigate whether a 20 min application of crushed ice at the knee affects knee joint kinematics immediately post and up to 20 mins post ice removal, during a small knee bend...
March 6, 2018: Gait & Posture
Damien J Lazar, Jonathan D Lichtenstein, David J Tybor
Background: Ultimate Frisbee (ultimate) is a fast-growing, popular sport played nationally by over 4 million athletes. While several studies have examined injury rates in ultimate, no work has investigated the prevalence of concussions specifically or players' knowledge and management of those injuries. Purpose: To estimate the lifetime prevalence of concussions in ultimate and to assess players' knowledge of concussions as well as their concussion management behaviors...
March 2018: Orthopaedic Journal of Sports Medicine
Lisa Wagels, Mikhail Votinov, Thilo Kellermann, Albrecht Eisert, Cordian Beyer, Ute Habel
Testosterone affects human social behavior in various ways. While testosterone effects are generally associated with muscular strength and aggressiveness, human studies also point towards enhanced status-seeking motives after testosterone administration. The current study tested the causal influence of exogenous testosterone on male behavior during a competitive provocation paradigm. In this double blind, randomized, placebo (PL)-controlled study, 103 males were assigned to a PL or testosterone group receiving a colorless PL or testosterone gel...
2018: Frontiers in Behavioral Neuroscience
Pablo A Cortes, Francisco Bozinovic, Pierre U Blier
Mammalian torpor is a phenotype characterized by a controlled decline of metabolic rate, generally followed by a reduction in body temperature. During arousal from torpor, both metabolic rate and body temperature rapidly returns to resting levels. Metabolic rate reduction experienced by torpid animals is triggered by active suppression of mitochondrial respiration, which is rapidly reversed during rewarming process. In this study, we analyzed the changes in the maximal activity of key enzymes related to electron transport system (complexes I, III and IV) in six tissues of torpid, arousing and euthermic Chilean mouse-opossums (Thylamys elegans)...
March 15, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Caitlin Sandman, Benjamin Krainin, Jamie Roper
BACKGROUND: Type II diabetes mellitus (DM) is an increasingly prevalent cause of morbidity and mortality among U.S. adults, with increasing prevalence in emergency department (ED) visits. Multiple medications, such as exenatide, a glucagon-like peptide-1 agonist, have been developed in the past decade to combat this growing problem. This medication is well documented to cause gastrointestinal upset and skin nodules at the injection site. However, currently no documented cases exist regarding manipulation of injection nodules causing increased absorption or reports demonstrating an increase in adverse drug reactions...
March 15, 2018: Journal of Emergency Medicine
Enda King, Andrew Franklyn-Miller, Chris Richter, Eamon O'Reilly, Mark Doolan, Kieran Moran, Siobhan Strike, Éanna Falvey
BACKGROUND: Clinical assessments and rehabilitation in athletic groin pain (AGP) have focused on specific anatomical structures and uniplanar impairments rather than whole body movement. OBJECTIVE: To examine the effectiveness of rehabilitation that targeted intersegmental control in patients with AGP and to investigate post rehabilitation changes in cutting biomechanics. METHODS: Two hundred and five patients with AGP were rehabilitated focusing on clinical assessment of intersegmental control, linear running and change of direction mechanics in this prospective case series...
March 17, 2018: British Journal of Sports Medicine
Cindy Lin, Ellen Casey, Daniel Herman, Nicole Katz, Adam Tenforde
Common sports injuries include bone stress injuries (BSI), anterior cruciate ligament injuries (ACL), and concussions. Less commonly recognized are the specific sex differences in epidemiology, risk factors, and outcomes of these conditions by sex. An understanding of these factors can improve their clinical management, from prescribing appropriate prehabilitation to guiding post injury rehabilitation and return to play. This narrative review summarizes the sex differences in the diagnosis and management of BSI, ACL injuries, and concussions...
March 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
C Kajetanek, O Benoît, B Granger, F Menegaux, N Chereau, H Pascal-Mousselard, F Khiami
BACKGROUND: Surgery for athletic pubalgia usually consists in abdominal wall repair combined with routine bilateral adductor tenotomy. We currently confine the surgical procedure to the injured structure(s) (abdominal wall only, adductor tendon only, or both) to limit morbidity and expedite recovery. Outcomes of this à la carte approach are unclear. The objectives of this retrospective study were to determine the return to play (RTP) time, evaluate the potential influence of injury location, and assess the frequency of recurrence or contralateral involvement...
March 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Laurel D Sarfan, Meghan W Cody, Elise M Clerkin
Although social anxiety symptoms are robustly linked to biased self-evaluations across time, the mechanisms of this relation remain unclear. The present study tested three maladaptive emotion regulation strategies - state post-event processing, state experiential avoidance, and state expressive suppression - as potential mediators of this relation. Undergraduate participants (N = 88; 61.4% Female) rated their social skill in an impromptu conversation task and then returned to the laboratory approximately two days later to evaluate their social skill in the conversation again...
March 16, 2018: Cognition & Emotion
Hossein Zanjanian, Hamid Abdolabadi, Mohammad Hossein Niksokhan, Amin Sarang
Allocating water to organizational stakeholders poses a vital challenge to water managers. Organizations which benefit from water as the primary factor input attempt to achieve their objectives using cost-effective and quick-return strategies, such as increasing the water rights. In such circumstances, lack of water probably results in the conflict. Recognizing the management approaches, organizational priorities, and the stakeholders' influence power can play a dominant role in analyzing the future of such conflicts...
March 10, 2018: Journal of Environmental Management
Cui Zhang, Liang Li, Yuanda Jiang, Cuicui Wang, Baoming Geng, Yanqiu Wang, Jianling Chen, Fei Liu, Peng Qiu, Guangjie Zhai, Ping Chen, Renfu Quan, Jinfu Wang
Bone formation is linked with osteogenic differentiation of mesenchymal stem cells (MSCs) in the bone marrow. Microgravity in spaceflight is known to reduce bone formation. In this study, we used a real microgravity environment of the SJ-10 Recoverable Scientific Satellite to examine the effects of space microgravity on the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs). hMSCs were induced toward osteogenic differentiation for 2 and 7 d in a cell culture device mounted on the SJ-10 Satellite...
March 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Juliana Vieira Dias, Celine Gloaguen, Dimitri Kereselidze, Line Manens, Karine Tack, Teni G Ebrahimian
A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on functional and molecular responses of human aorta endothelial cells (HAoECs). Human aorta endothelial cells were continuously irradiated at LDR (6 mGy/h) for 15 days and analyzed at time points when the cumulative dose reached 0...
January 2018: Dose-response: a Publication of International Hormesis Society
James Rafferty, Craig Ranson, Giles Oatley, Mohamed Mostafa, Prabhat Mathema, Tom Crick, Isabel S Moore
OBJECTIVES: To investigate concussion injury rates, the likelihood of sustaining concussion relative to the number of rugby union matches and the risk of subsequent injury following concussion. METHODS: A four-season (2012/2013-2015/2016) prospective cohort study of injuries in professional level (club and international) rugby union. Incidence (injuries/1000 player-match-hours), severity (days lost per injury) and number of professional matches conferring a large risk of concussion were determined...
March 12, 2018: British Journal of Sports Medicine
Elif Turgut, Volga Bayrakci Tunay
OBJECTIVE: Kerlan-Jobe Orthopaedic Clinic Shoulder and Elbow Score (KJOC-SES) is a subjective assessment tool to measure functional status of the upper extremities in overhead athletes. The aim was to translate and culturally adapt the KJOC-SES and to evaluate the psychometric properties of the Turkish version (KJOC-SES-Tr) in overhead athletes. METHODS: The forward and back-translation method was followed. One hundred and twenty-three overhead athletes completed the KJOC-SES-Tr, the Disabilities of the Arm, Shoulder, and Hand (DASH), and the American Shoulder and Elbow Surgeons Evaluation Form (ASES)...
March 9, 2018: Acta Orthopaedica et Traumatologica Turcica
Zaira S Chaudhry, Steven M Raikin, Marc I Harwood, Meghan E Bishop, Michael G Ciccotti, Sommer Hammoud
BACKGROUND: Although most anterior tibial stress fractures heal with nonoperative treatment, some may require surgical management. To our knowledge, no systematic review has been conducted regarding surgical treatment strategies for the management of chronic anterior tibial stress fractures from which general conclusions can be drawn regarding optimal treatment in high-performance athletes. PURPOSE: This systematic review was conducted to evaluate the surgical outcomes of anterior tibial stress fractures in high-performance athletes...
December 1, 2017: American Journal of Sports Medicine
Stephanie M Merwin, Chelsey Barrios, Victoria C Smith, Edward P Lemay, Lea R Dougherty
This study examined the impact of parent-child attunement of morning cortisol on parenting and child outcomes in dyads with and without parental depression. Participants included 142 parent-child dyads (3-5 years-old) who provided morning cortisol samples at Wave 1, and 98 dyads returned for the 3-year follow-up at Wave 2. Results indicated that for parents with a history of depression and for female children, stronger attunement predicted increases in parental hostility from Wave 1 to Wave 2. For females only, stronger attunement was related to children's depressive symptoms at Wave 1 and Wave 2...
March 12, 2018: Developmental Psychobiology
S Rebekah Burket, Yelena Sapozhnikova, Shan S Chung, Bryan W Brooks
Aquaculture, which is growing 3-5 times faster than terrestrial agriculture, will play an important role to meet future global food production needs. However, over 80% of global sewage production is returned to the environment untreated or poorly treated. In developing nations, these non-traditional waters of diverse quality are being recycled for aquaculture, yet chemical residues are differentially studied. Here, we examined pharmaceuticals, pesticides, PCBs, PBDEs, PAHs and flame retardants in marine bivalves using isotope dilution LC-MS/MS and low pressure (LP)GC-MS/MS...
March 10, 2018: Journal of Agricultural and Food Chemistry
Xiaobing Jiang, Yinsheng Chen, Zhihuan Zhou, Liping Luo, Wanming Hu, Huirong Zheng, Zhe Zhu, Jian Wang, Zhongping Chen
BACKGROUND: The pineal gland has been demonstrated to be involved in the development of mood and psychotic disorders. However, few studies have looked at the relationship between pineal region tumors and psychiatric disorders. Intracranial epidermoid cysts usually arise in cerebellopontine angle area, and are extremely rare in the pineal region. The case of pineal epidermoid cyst presenting as schizophrenia has never been reported before. CASE PRESENTATION: We described the case of a 23-year old man who presented to hospital with symptoms suggestive of schizophrenia...
March 7, 2018: World Neurosurgery
Jing-Jing Liu, Guo-Chang Zhang, In Iok Kong, Eun Ju Yun, Jia-Qi Zheng, Dae-Hyuk Kweon, Yong-Su Jin
The probiotic yeast Saccharomyces boulardii has been extensively studied for preventing and treating diarrheal diseases and is now commercially available in some countries. S. boulardii displays notable phenotypes, such as high optimal growth temperature, high tolerance against acidic conditions, and the inability to form ascospores, which differentiate S. boulardii from S. cerevisiae The majority of prior studies stated that S. boulardii exhibits sluggish or halted galactose utilization. Nonetheless, molecular mechanisms underlying inefficient galactose uptake have yet to be elucidated...
March 9, 2018: Applied and Environmental Microbiology
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