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https://www.readbyqxmd.com/read/28738169/behavior-of-sulfur-mustard-in-sand-concrete-and-asphalt-matrices-evaporation-degradation-and-decontamination
#1
Hyunsook Jung, Seungki Choi
The evaporation, degradation, and decontamination of sulfur mustard on environmental matrices including sand, concrete, and asphalt are described. A specially designed wind tunnel and thermal desorber in combination with gas chromatograph (GC) produced profiles of vapor concentration obtained from samples of the chemical agent deposited as a drop on the surfaces of the matrices. The matrices were exposed to the chemical agent at room temperature, and the degradation reactions were monitored and characterized...
July 24, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28737434/defining-the-timing-of-25-oh-d-rescue-following-nitrogen-mustard-exposure
#2
Lopa M Das, Amy M Binko, Zachary P Traylor, Lori Duesler, Kurt Q Lu
OBJECTIVE: Mass exposure to alkylating agents such as nitrogen mustard (NM), whether accidental or intentional as during warfare, are known to cause systemic toxicity and severe blistering from cutaneous exposure. Thus, establishing the timing and appropriate dose of any potential drug designed to reverse or impede these toxicities is critical for wound repair and survival. Our previous data demonstrates that a single intraperitoneal injection of low-dose 25-hydroxyvitamin D3 (25(OH)D) given as early as 1 hour following NM exposure is sufficient to rescue mice from pancytopenia and death...
July 24, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28730300/health-related-quality-of-life-in-paediatric-patients-with-congenital-heart-defects-association-with-the-type-of-heart-defect-and-the-surgical-technique
#3
A Heusch, H J Kahl, K O Hensel, G Calaminus
The aim of the study was to investigate the impact of a number of surgical interventions for a various congenital cardiac defects (CHDs) on self-reported HRQoL. METHODS: Patients who had received corrective surgery of several congenital heart defects (surgical VSD closure, Fallot, TGA after atrial or arterial switch or Fontan-type circulation for univentricular AV-connection) were interviewed in the office of their home peadiatric cardiologist. HRQoL in children along 7 dimensions was assessed using a standardised questionnaire (PEDQoL); information on the medical case history of each respondent was also collected...
July 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28724198/direct-and-topoisomerase-ii-mediated-dna-damage-by-bis-3-chloropiperidines-the-importance-of-being-an-earnest-g
#4
Alice Sosic, Ivonne Zuravka, Nina-Katharina Schmitt, Angelica Miola, Richard Göttlich, Dan Fabris, Barbara Gatto
Bis-3-chloropiperidines are a new class of DNA-active compounds capable of alkylating nucleobases and inducing strand cleavage. In this report, we investigated the reactivity of these mustard-based agents with both single- and double-stranded DNA constructs. Polyacrylamide gel electrophoresis (PAGE) and electrospray ionization mass spectrometry (ESI-MS) were employed to obtain valuable insights into their mechanism at the molecular level and to investigate their time- and concentration-dependence. The results revealed the preferential formation of mono- and bifunctional adducts at nucleophilic guanine sites...
July 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28720507/formation-and-degradation-of-nitrogen-mustard-induced-mgmt-dna-crosslinking-in-16hbe-cells
#5
Jin Cheng, Feng Ye, Guorong Dan, Yuanpeng Zhao, Jiqing Zhao, Zhongmin Zou
N-methyl-2,2-di(chloroethyl)amine (HN2) is a kind of bifunctional alkyltating agent, which can react with nucleophilic groups in DNA and/or protein to form HN2-bridged crosslinking of target molecules, such as DNA-protein crosslinkings (DPC). O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA damage repair enzyme which solely repairs alkyl adduct on DNA directly. However, MGMT was detected to act as a protein cross-linked with DNA via alkylation in presence of HN2, and unexpectedly turned into a DNA damage enhancer in the form of MGMT-DNA cross-link (mDPC)...
July 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28716702/how-to-perform-transconduit-and-transbaffle-puncture-in-patients-who-have-previously-undergone-the-fontan-or-mustard-operation
#6
Jae-Sun Uhm, Nam Kyun Kim, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
No abstract text is available yet for this article.
July 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28710962/discovery-of-potent-molecular-chimera-cm358-to-treat-human-metastatic-melanoma
#7
Y Gilad, H Tuchinsky, G Ben-David, R Minnes, A Gancz, H Senderowitz, G Luboshits, M A Firer, G Gellerman
The resistance of cancer cells to chemotherapeutic agents, whether through intrinsic mechanisms or developed resistance, motivates the search for new chemotherapeutic strategies. In the present report, we demonstrate a facile synthetic strategy towards the discovery of new anti-cancer substances. This strategy is based on simple covalent coupling between known anti-cancer drugs, which results in novel 'chimeric' small molecules. One of these novel compounds, CM358, is the product of an amide bond formation between the known Topoisomerase II (Topo II) inhibitor amonafide (AM) and the known DNA mustard alkylator chlorambucil (CLB)...
June 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28709569/selected-active-naturals-for-atopic-dermatitis-atopic-dermatitis-part-1
#8
Nanette B Silverberg
The desire for naturally derived agents is a growing trend for patients, physicians, and pharmaceutical companies. Studies indicate that complementary and alternative medicine is often used by patients and parents of children with atopic dermatitis, not necessarily with beneficial results. A half-dozen natural agents (ie, topical agents: coconut oil, colloidal oatmeal, sunflower oil, mustard oil, glycerin, and oral Chinese herbal therapy) are discussed because they have become popular for their expected activity in the therapy of atopic dermatitis...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28702918/assessment-of-potential-health-risk-of-fluoride-consumption-through-rice-pulses-and-vegetables-in-addition-to-consumption-of-fluoride-contaminated-drinking-water-of-west-bengal-india
#9
Piyal Bhattacharya, Alok Chandra Samal, Suman Banerjee, Jagadish Pyne, Subhas Chandra Santra
A study was conducted in fluoride-affected Bankura and Purulia districts of West Bengal to assess the potential health risk from fluoride exposure among children, teenagers, and adults due to consumption of rice, pulses, and vegetables in addition to drinking water and incidental ingestion of soil by children. Higher mean fluoride contents (13-63 mg/kg dry weight) were observed in radish, carrot, onion bulb, brinjal, potato tuber, cauliflower, cabbage, coriander, and pigeon pea. The combined influence of rice, pulses, and vegetables to cumulative estimated daily intake (EDI) of fluoride for the studied population was found to be 9...
July 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28689216/concentration-of-alpha-fetoprotein-and-%C3%AE-eta-human-chorionic-gonadotropin-tumor-markers-in-sulfur-mustard-exposed-veterans
#10
Mohammad Rafiee, Yunes Panahi, Mohammad Yousef Alikhani, Hassan Rafieemehr, Alireza Saadat, Mohammad Abbasi
No abstract text is available yet for this article.
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28686257/an-alkylating-immobilization-linker-for-immunochemical-epigenetic-assessment
#11
Takaaki Kurinomaru, Naoshi Kojima, Ryoji Kurita
A bifunctional linker molecule containing nitrogen mustard and a cyclic disulfide group has been developed for the covalent immobilization of intact DNA, which allows quantitative analysis of epigenomic modification in immobilized DNA using SPR-based immune sensing.
July 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28670246/relationship-of-serum-levels-of-interleukin-6-interleukin-8-and-c-reactive-protein-with-forced-expiratory-volume-in-first-second-in-patients-with-mustard-lung-and-chronic-obstructive-pulmonary-diseases-systematic-review-and-meta-analysis
#12
Alireza Shahriary, Yunes Panahi, Saeed Shirali, Hossein Rahmani
INTRODUCTION: The chronic systemic inflammation is a result of releasing inflammatory cytokines from the cells relating to the body immunity system and chronic activation of the innate immunity system. AIM: To evaluate the relationship among serum levels of interleukin 6 (IL-6), interleukin 8 (IL-8), C-reactive protein (CRP) with forced expiratory volume in 1(st) s (FEV1) in patients with mustard lung (ML) and chronic obstructive pulmonary diseases (COPD). MATERIAL AND METHODS: A published literature search was performed through SID, web of science, ISI, Science Direct, Scopus, Medline, and PubMed databases for articles published in English...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28667758/tgf-%C3%AE-and-th17-cells-related-injuries-in-patients-with-sulfur-mustard-exposure
#13
REVIEW
Yunes Panahi, Mostafa Ghanei, Saeed Hassani, Amirhossein Sahebkar
Sulfur mustard (SM) is a vesicating agent that has been employed as a chemical warfare agent. High-dose exposure to sulfur mustard may lead to the damage of rapidly proliferating cells of bone marrow and, therefore, suppression of the immune system. This may be continued as dysfunction of the immune system, and ultimately result in secondary immune disorders. Studies have suggested a role for T cells in SM-induced lung injury. Moreover, observations from animal studies indicate a delayed-type hypersensitivity (DTH) response after skin exposure to SM, providing an understanding that SM can stimulate specific T cell-mediated immune responses...
July 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28666523/reconstruction-techniques-of-choice-for-the-facial-cosmetic-units
#14
F Russo, M Linares, M E Iglesias, J L Martínez-Amo, F Cabo, J Tercedor, R Costa-Vieira, T Toledo-Pastrana, J M Ródenas, V Leis
BACKGROUND AND OBJECTIVES: A broad range of skin flaps can be used to repair facial surgical defects after the excision of a tumor. The aim of our study was to develop a practical guideline covering the most useful skin grafts for each of the distinct facial cosmetic units. MATERIAL AND METHODS: This was a multicenter study in which 10 dermatologists with extensive experience in reconstructive surgery chose their preferred technique for each cosmetic unit. The choice of flaps was based on personal experience, taking into account factors such as suitability of the reconstruction technique for the specific defect, the final cosmetic result, surgical difficulty, and risk of complications...
June 27, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28663125/characterization-of-three-serotonin-receptors-from-the-small-white-butterfly-pieris-rapae
#15
Yi-Xiang Qi, Miao Jin, Xu-Yang Ni, Gong-Yin Ye, Youngseok Lee, Jia Huang
Serotonin (5-hydroxytryptamine, 5-HT) plays a key role in modulating diverse physiological processes and behaviors in both protostomes and deuterostomes. These functions are mediated through the binding of serotonin to its receptors, which are recognized as potential insecticide targets. We investigated the sequence, pharmacology and tissue distribution of three 5-HT receptors (Piera5-HT1A, Piera5-HT1B, Piera5-HT7) from the small white butterfly Pieris rapae, an important pest of cultivated cabbages and other mustard family crops...
June 27, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28658983/melphalan-hydrochloride-for-the-treatment-of-multiple-myeloma
#16
Fabrizio Esma, Marco Salvini, Rossella Troia, Mario Boccadoro, Alessandra Larocca, Chiara Pautasso
Multiple myeloma (MM) is an incurable disease characterized by clonal plasma cell proliferation and overproduction of monoclonal paraprotein, hypercalcemia, renal failure, anemia, osteolytic bone lesions, and infections. Melphalan, a nitrogen mustard, is an alkylating agent synthesized in 1953, and it has been used in multiple myeloma therapy for fifty years. Although novel agents have been introduced in the past few decades improving prognosis of the disease, melphalan still maintains a crucial role in the treatment of MM acting both as cytotoxic agent through damage to DNA, and as immunostimulatory drug by inhibiting Interleukin-6, as well as interaction with dendritic cells, and immunogenic effects in tumor microenvironment...
August 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28657650/a-review-on-symptoms-treatments-protocols-and-proteomic-profile-in-sulfur-mustard-exposed-victims
#17
Amir Hossein Abdolghaffari, Yunes Panahi, Amirhossein Sahebkar
Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apoptosis and inflammation. Sulfur mustard penetrated body organs and induces long term eye, skin, lung, gastrointestinal, urogenital damages and can cause carcinogenic and mutagenic consequences. Currently there is no definitive treatment protocol for SM exposed patients...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28655650/mechanical-wounding-promotes-local-and-long-distance-response-in-the-halophyte-cakile-maritima-through-the-involvement-of-the-ros-and-rns-metabolism
#18
Hayet Houmani, Marta Rodríguez-Ruiz, José M Palma, Francisco J Corpas
Mechanical wounding in plants, which are capable of generating defense responses possibly associated with nitro-oxidative stress, can be caused by (a)biotic factors such as rain, wind, herbivores and insects. Sea rocket (Cakile maritima L.), a halophyte plant belonging to the mustard family Brassicaceae, is commonly found on sandy coasts throughout Europe. Using 7-day-old Cakile maritima L. seedlings, mechanical wounding was induced in hypocotyls by pinching with a striped-tip forceps; after 3 h, several biochemical parameters were analyzed in both the damaged and unwounded organs (green cotyledons and roots)...
June 24, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28653852/chemical-warfare-agents-detoxification-properties-of-zirconium-metal-organic-frameworks-by-synergistic-incorporation-of-nucleophilic-and-basic-sites
#19
Rodrigo Gil-San-Millan, Elena López-Maya, Morgan Hall, Natalia M Padial, Gregory W Peterson, Jared B DeCoste, L Marleny Rodríguez-Albelo, J Enrique Oltra, Elisa Barea, Jorge A R Navarro
The development of protective self-detoxifying materials is an important societal challenge to counteract risk of attacks employing highly toxic chemical warfare agents (CWAs). In this work, we have developed bifunctional zirconium metal-organic frameworks (MOFs) incorporating variable amounts of nucleophilic amino residues by means of formation of the mixed ligand [Zr6O4(OH)4(bdc)6(1-x)(bdc-NH2)6x] (UiO-66-xNH2) and [Zr6O4(OH)4(bpdc)6(1-x)(bpdc-(NH2)2)6x] (UiO-67-x(NH2)2) systems where bdc = benzene-1,4-dicarboxylate; bdc-NH2= benzene-2-amino-1,4-dicarboxylate; bpdc = 4,4'-biphenyldicarboxylate; bpdc-(NH2)2 = 2,2'-diamino-4,4'-biphenyldicarboxylate and x = 0, 0...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653831/detoxification-of-a-sulfur-mustard-simulant-using-a-bodipy-functionalized-zirconium-based-metal-organic-framework
#20
Ahmet Atilgan, Timur Islamoglu, Ashlee J Howarth, Joseph T Hupp, Omar K Farha
Effective detoxification of chemical warfare agents is a global necessity. As a powerful photosensitizer, a halogenated BODIPY ligand is postsynthetically appended to the Zr6 nodes of the metal-organic framework (MOF), NU-1000, to enhance singlet oxygen generation from the MOF. The BODIPY/MOF material is then used as a heterogeneous photocatalyst to produce singlet oxygen under green LED irradiation. The singlet oxygen selectively detoxifies the sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES), to the less toxic sulfoxide derivative (2-chloroethyl ethyl sulfoxide, CEESO) with a half-life of approximately 2 min...
July 17, 2017: ACS Applied Materials & Interfaces
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