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Eisa Tahmasbpour, Mostafa Ghanei, Abolfazl Khor, Yunes Panahi
CONTEXT: Sulfur mustard (SM) is a strong alkylating toxicant that targets different organs, particularly human lung tissue. Change in genes expression is one of the molecular mechanisms of SM toxicity in damaged tissue. OBJECTIVE: The purpose of this investigation is to characterize the expression of cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LO), inducible nitric oxide synthase 2 (iNOS2), and surfactant protein D (SFTPD) in lungs of patients who exposed to SM...
March 14, 2018: Drug and Chemical Toxicology
Satyanarayana Achanta, Narendranath Reddy Chintagari, Marian Brackmann, Shrilatha Balakrishna, Sven-Eric Jordt
The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antidotes against SM are available. Recent studies demonstrated that Transient Receptor Potential Ankyrin 1 (TRPA1), a chemosensory cation channel in sensory nerves innervating the skin, is activated by SM and 2-chloroethyl ethyl sulfide (CEES), an SM analog, in vitro, suggesting it may promote vesicant injury...
March 10, 2018: Toxicology Letters
Frederik Helsen, Pieter De Meester, Alexander Van De Bruaene, Charlien Gabriels, Béatrice Santens, Mathias Claeys, Guido Claessen, Kaatje Goetschalckx, Roselien Buys, Marc Gewillig, Els Troost, Jens-Uwe Voigt, Piet Claus, Jan Bogaert, Werner Budts
BACKGROUND: To evaluate the relationship between right ventricular (RV) systolic dysfunction at rest and reduced exercise capacity in patients with a systemic RV (sRV). METHODS: All patients with congenitally corrected transposition of the great arteries (ccTGA) or complete TGA after atrial switch (TGA-Mustard/Senning) followed in our institution between July 2011 and September 2017 who underwent cardiac imaging within a six-month time period of cardiopulmonary exercise testing (CPET) were analyzed...
March 8, 2018: International Journal of Cardiology
Yuanlin Zhang, Yanlin Lv, Xuefei Wang, Aidong Peng, Kaiquan Zhang, Xiaoke Jie, Jijun Huang, Zhiyuan Tian
A newl type of fluorescent probe capable of detecting sulfur mustard (SM) simultant with concentration of 1.2 μM in solution and 0.5 ppm in gas phase has been developed. Owing to its molecular structure with thiocarbonyl component and two piperidyl moieties integrated into the xanthene molecular skeleton, this probe underwent a highly selective nucleophilic reaction with SM simultant and generated a thiopyronin derivative emitting intensive pink fluorescence. The distinct difference in electronic structure between the probe and thiopyronin derivative caused a marked shift of the absorbance band from 445 nm to 567 nm, which enabled an optimal wavelength propitious to excite the thiopyronin derivative but adverse to the probe...
March 12, 2018: Analytical Chemistry
Maria Isidoria Silva Gonzaga, Cheryl Mackowiak, André Quintão de Almeida, Alberto Wisniewski, Danyelle Figueiredo de Souza, Idamar da Silva Lima, Amanda Nascimento de Jesus
Copper contamination and toxicity in soils is a worldwide problem, especially in areas where copper-based fungicides are applied. Indian mustard (Brassica juncea L.) plants are used in phytoremediation and are also edible crops commonly cultivated in organic agricultural areas. Application of biochar to Cu contaminated soils may reduce Cu availability and uptake, thereby allowing for greater Indian mustard production. A (3 × 2) + 1) experiment in a randomized complete block design was used to evaluate the effect of three different biochars (coconut shell, orange bagasse and sewage sludge) and two application rates (30 and 60 t ha-1 ) on Cu uptake by Indian mustard during three successive growth cycles and Cu immobilization in soil, under greenhouse conditions...
March 5, 2018: Chemosphere
Mark Dennis, Irina Kotchetkova, Rachael Cordina, David S Celermajer
BACKGROUND: The atrial switch operation for transposition of the Great Arteries (TGA) (Mustard or Senning Procedure) provides excellent short-term survival. Significant long-term concerns exist for these patients, however, including the ability of the right ventricle to maintain systemic perfusion and the risk of arrhythmia. We seek to describe long-term mortality and morbidity of this group of adult patients. METHODS: Consecutive patients who had undergone an atrial switch procedure, who were aged over 16 years and who were followed up at our tertiary level adult congenital heart disease (ACHD) service in Sydney, Australia since 2000 were included...
October 31, 2017: Heart, Lung & Circulation
Tong Han, Kangtao Tian, Huaqi Pan, Yongxiang Liu, Fanxing Xu, Zhanlin Li, Takahiro Uchita, Ming Gao, Huiming Hua, Dahong Li
A series of novel conjugates of brefeldin A (11a-c, 12a-c and 13a-c) were obtained by introducing a variety of nitrogen mustards at 4-OH or 7-OH position to explore more efficacious and less toxic antitumor agents. The antiproliferative activities were tested against three cancer cell lines (HL-60, PC-3 and Bel-7402) and one multidrug resistant cell line Bel-7402/5-FU. Among them, compound 11a was the strongest derivative with IC50 values of 4.48, 9.37, 0.2 and 0.84 μM, respectively, and more potent than nitrogen mustards...
March 1, 2018: European Journal of Medicinal Chemistry
Maggie R Wagner, Thomas Mitchell-Olds
Phenotypic plasticity is thought to impact evolutionary trajectories by shifting trait values in a direction that is either favored by natural selection ("adaptive plasticity") or disfavored ("nonadaptive" plasticity). However, it is unclear how commonly each of these types of plasticity occurs in natural populations. To answer this question, we measured glucosinolate defensive chemistry and reproductive fitness in over 1,500 individuals of the wild perennial mustard Boechera stricta, planted in four common gardens across central Idaho, USA...
March 9, 2018: Evolution; International Journal of Organic Evolution
Surendra S Agrawal, Tapasya P Yallatikar, Pravina N Gurjar
Brassica nigra belonging to the family Brassicaceae (syn - black mustard) comprises of dried seeds and is widely cultivated in Mediterranean region and various other countries like India and Europe. B. nigra contains glycosinolates which undergoes hydrolysis in the presence of myrosinase enzyme yields allyl isothiocyante. The bitter taste and pungent odor is due to the isothiocyanates. B. Nigra shows various activities that are medically important such as anticancer, anti-bacterial, anti-fungal, anti-helminthic, protection against renal and hepatic toxicity and can also be used in diabetes treatment...
March 8, 2018: Current Drug Discovery Technologies
Ayan Das, Prithwi Ghosh, Sampa Das
Transgenic Brassica juncea plants expressing Colocasia esculenta tuber agglutinin (CEA) shows the non-allergenic nature of the expressed protein leading to enhanced mortality and reduced fecundity of mustard aphid-Lipaphis erysimi. Lipaphis erysimi (common name: mustard aphid) is the most devastating sucking insect pest of Indian mustard (Brassica juncea L.). Colocasia esculenta tuber agglutinin (CEA), a GNA (Galanthus nivalis agglutinin)-related lectin has previously been reported by the present group to be effective against a wide array of hemipteran insects in artificial diet-based bioassays...
March 8, 2018: Plant Cell Reports
Papaiah Sardaru, Laura Sinausía, Silvia López-González, Jelena Zindovic, Flora Sánchez, Fernando Ponz
Two different isolates of Turnip mosaic virus (UK 1 and JPN 1) belonging to different virus strains were tested on three different Brassica species, namely turnip (Brassica rapa L.), Indian mustard (Brassica juncea L.), and Ethiopian mustard (Brassica carinata A. Braun). Whereas all three hosts were readily infected by isolate UK 1, isolate JPN 1 was able to establish a visible systemic infection only in the first two. Ethiopian mustard plants showed no local or systemic symptoms, and no virus antigens could be detected by ELISA...
March 8, 2018: Molecular Plant Pathology
Eman M Mohi El-Deen, Eman K Abd El-Hameed
Synthesis of a series of novel 10-substituted-pyrido[3',2':4,5]thieno[3,2-b] quinoline derivatives 3-15, which contain a planar tetracyclic heteroring system, has been accomplished. The synthetic approaches for the target compounds included, condensation reaction of 10-amino derivatives 2 with triethyl orthoformate to give ethyl N-formimidate derivatives 3, which in turn reacted with different amines to give N-substituted formimidamide derivatives 4a,b. In addition, N-mustard derivative 6 was synthesized via treatment of 2,2'- azanediylbis(ethan-1-ol) derivative 5 with thionyl chloride...
May 2017: Acta Poloniae Pharmaceutica
Halina Jurkowska, Maria Wróbel, Dominika Szlęzak, Ewa Jasek-Gajda
The effect of 4-hydroxybenzyl isothiocyanate (HBITC), a natural H2 S-donor from white mustard seeds (Sinapis alba), on the proliferation of human neuroblastoma (SH-SY5Y) and glioblastoma (U87MG) cells was studied and some aspects of the mechanism of its activity were suggested. The inhibition of both SH-SY5Y and U87MG cell proliferation was associated with an increase in the thiosulfate level, the number of cells with the inactive form of Bcl-2 protein, and with a decrease of mitochondrial membrane potential...
March 5, 2018: Amino Acids
Mehdi Dehghani Firoozabadi, Mohammad Ali Sheikhi, Hossein Rahmani, Ahmad Ebadi, Amanollah Heidari, Behnam Gholizadeh, Khosrow Sharifi
Sulfur mustard (SM) is a toxic chemical agent that belongs to a class of vesicant compounds. In the 1980s it was used by the Iraqi army against Iranian forces. Sulfur mustard severely irritates the skin, eyes and lungs. The highest side effects seen in patients affected by this gas are pulmonary complications including different types of lung diseases such as bronchiolitis. It has also led to a certain type of chronic obstructive pulmonary disease called mustard lung. Similar extra-pulmonary, molecular and hormonal effects can be observed in these patients and patients with chronic obstructive pulmonary disease...
October 2017: Postȩpy Dermatologii i Alergologii
Patrícia Silva de Camargo, Carla Rigo Lima, Maria Luiza de Andrade E Rezende, Adriana Teresa Silva Santos, João Wagner Rodrigues Hernandez, Andréia Maria Silva
The purpose of this study was to analyze and compare intra and intergroup the immediate effect of the auricular and LR8 systemic acupuncture on the electromyographic activity of the trapezius with the trigger points. This is an experimental clinical trial; 40 people were split in 4 distinct groups (n = 10): GI mustard seed application in the auricular acupoint; GII bilateral needle application in the LR8 acupoint; GIII combination of the techniques; GIV/Control Group mustard seed application in an acupoint not linked to the muscle tension...
February 2018: Journal of Acupuncture and Meridian Studies
Katherine Cools, Leon A Terry
Brassica juncea mustard seed are used to make mustard paste or condiment. Mustard seed contains glucosinolates which are converted to isothiocyanates following cell disruption by the enzyme, myrosinase. Isothiocyanates are sulphur-containing compounds which give a pungent flavour to the mustard condiment. Three mustard seed cultivars from two seasons were processed into Dijon- and wholegrain-style mustard and glucosinolates and isothiocyanates analysed. Canadian cv. Centennial tended to contain higher glucosinolates compared with the French cv...
June 30, 2018: Food Chemistry
Tarek A Morsy, Ahmed E Kholif, Osama H Matloup, Amgad Abu Elella, Uchenna Y Anele, Joel S Caton
The experiments reported in this Research Paper aimed to study the effects of mustard and cumin seeds inclusion on feed utilisation, milk production, composition, and profile of milk fatty acids in lactating Damascus goats. The study was a completely randomised design with repeated measurements in time using fifteen goats (6 ± 2 d of lactation) divided into 3 treatments (5 goats per treatment). Goats were offered a control diet of berseem clover and concentrates (1 : 1 dry matter (DM) basis) or the control diet supplemented with either 10 g/d of dried mustard seeds (mustard treatment) or 10 g/d of cumin seeds (cumin treatment) for 12 weeks...
February 26, 2018: Journal of Dairy Research
Benoit I M M Hendrickx, Moustapha Hamdi, Assaf Zeltzer, Andrew Greensmith
BACKGROUND: Prominent ears are by far the most common congenital ear deformity. Many techniques have been described using one or a combination of 3 basic methods: cartilage cutting, cartilage weakening and pure cartilage shaping techniques. The ideal otoplasty technique should yield a natural correction of the deformity, with low recurrence rates and with little risk of complications. METHODS: A new cartilage shaping technique using closing wedge concentric microchondrectomies through an entirely posterior approach is presented...
February 19, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
P San Segundo-Acosta, M Garranzo-Asensio, C Oeo-Santos, A Montero-Calle, J Quiralte, J Cuesta-Herranz, M Villalba, R Barderas
Olive pollen and yellow mustard seeds are major allergenic sources with high clinical relevance. To aid with the identification of IgE-reactive components, the development of sensitive methodological approaches is required. Here, we have combined T7 phage display and protein microarrays for the identification of allergenic peptides and mimotopes from olive pollen and mustard seeds. The identification of these allergenic sequences involved the construction and biopanning of T7 phage display libraries of mustard seeds and olive pollen using sera from allergic patients to both biological sources together with the construction of phage microarrays printed with 1536 monoclonal phages from the third/four rounds of biopanning...
February 19, 2018: Journal of Immunological Methods
Joseph Gbenga Omole, Oladele Abiodun Ayoka, Quadri Kunle Alabi, Modinat Adebukola Adefisayo, Muritala Abiola Asafa, Babalola Olusegun Olubunmi, Benson Akinloye Fadeyi
BACKGROUND: Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties. OBJECTIVE: This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats...
January 2018: J Evid Based Integr Med
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