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https://www.readbyqxmd.com/read/28635651/effects-of-tetrodotoxin-in-mouse-models-of-visceral-pain
#1
Rafael González-Cano, Miguel Ángel Tejada, Antonia Artacho-Cordón, Francisco Rafael Nieto, José Manuel Entrena, John N Wood, Cruz Miguel Cendán
Visceral pain is very common and represents a major unmet clinical need for which current pharmacological treatments are often insufficient. Tetrodotoxin (TTX) is a potent neurotoxin that exerts analgesic actions in both humans and rodents under different somatic pain conditions, but its effect has been unexplored in visceral pain. Therefore, we tested the effects of systemic TTX in viscero-specific mouse models of chemical stimulation of the colon (intracolonic instillation of capsaicin and mustard oil) and intraperitoneal cyclophosphamide-induced cystitis...
June 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28624757/implementation-of-a-disability-management-policy-in-a-large-healthcare-employer-a-quasi-experimental-mixed-methods-evaluation
#2
Cameron A Mustard, Kathryn Skivington, Morgan Lay, Marni Lifshen, Jacob Etches, Andrea Chambers
OBJECTIVE: This study describes the process and outcomes of the implementation of a strengthened disability management policy in a large Canadian healthcare employer. Key elements of the strengthened policy included an emphasis on early contact, the training of supervisors and the integration of union representatives in return-to-work (RTW) planning. DESIGN: The study applied mixed methods, combining a process evaluation within the employer and a quasi-experimental outcome evaluation between employers for a 3-year period prior to and following policy implementation in January 2012...
June 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28624590/maleic-acid-assisted-improvement-of-metal-chelation-and-antioxidant-metabolism-confers-chromium-tolerance-in-brassica-juncea-l
#3
Jubayer Al Mahmud, Mirza Hasanuzzaman, Kamrun Nahar, Anisur Rahman, Md Shahadat Hossain, Masayuki Fujita
Chromium (Cr) is a highly toxic environmental pollutant that negatively affects plant growth and development. Thus, remediating Cr from soil or increasing plant tolerance against Cr stress is urgent. Organic acids are recognized as agents of phytoremediation and as exogenous protectants, but using maleic acid (MA) to attain these results has not yet been studied. Therefore, our study investigated the effects of MA on Cr uptake and mitigation of Cr toxicity. We treated 8-d-old Indian mustard (Brassica juncea L...
June 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28618783/pulsed-light-emitting-diodes-for-higher-phytochemical-level-in-microgreens
#4
Viktorija Vaštakaitė, Akvilė Viršilė, Aušra Brazaitytė, Giedrė Samuolienė, Julė Jankauskienė, Algirdas Novičkovas, Pavelas Duchovskis
A novel research of pulsed LED lighting versus continuous lighting was conducted by analyzing phytochemicals levels in microgreens. Red pak choi (Brassica rapa var. chinensis), mustard (Brassica juncea L.) and tatsoi (Brassica rapa var. rosularis) were grown indoors under HPS lamps supplemented with monochromatic (455 nm, 470 nm, 505 nm, 590 nm and 627 nm) LEDs (total PPFD 200±10 µmol m(-2) s(-1); 16 h day(-1)). For pulsed light treatments, the frequencies at 2 Hz, 32 Hz, 256 Hz, and 1024 Hz with a duty cycle of 50% of monochromatic LEDs were applied...
June 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28617525/characterization-of-high-exopolysaccharide-producing-lactobacillus-strains-isolated-from-mustard-pickles-for-potential-probiotic-applications
#5
Jing-Yao Huang, Cheng-Yen Kao, We-Sin Liu, Tony J Fang
The aim of this study was to characterize high exopolysaccharide (EPS)-producing lactic acid bacteria (LAB) isolated from mustard pickles in Taiwan for potential probiotic applications. Among 39 collected LAB strains, four most productive EPS-producing strains were selected for further analysis. Comparative analyses of 16S rDNA genes rpoA and pheS sequences demonstrated that these strains were members of Lactobacillus plantarum-group (LPG). NCD 2, NLD 4, SLC 13, and NLD 16 showed survival rates of 95.83% ± 0...
June 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28614189/a-dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#6
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl-isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, 90%) and vehicle (paraffin) were applied for 5 min to 3x3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28597760/late-onset-pulmonary-arterial-hypertension-in-repaired-d-transposition-of-great-arteries-an-uncommon-complication
#7
Janani Baskaran, Kimara S March, Thenappan Thenappan
Late-onset pulmonary arterial hypertension (PAH) is a rare but fatal complication in patients with childhood surgical repair of dextro-transposition of great arteries (D-TGA), especially with the Mustard and Senning procedures. The pathogenic mechanisms of PAH in patients with repaired D-TGA are not well understood and treatment is not standardized. In this manuscript, we present a case of late-onset PAH in an adult D-TGA patient after Mustard repair and discuss the pathogenic mechanisms, diagnosis, and treatment of pulmonary hypertension in repaired D-TGA...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28582373/ocular-surface-changes-after-sulfur-mustard-exposure-in-rabbits-monitored-by-impression-cytology
#8
Shlomit Dachir, Hila Gutman, Ariel Gore, Liat Cohen, Maayan Cohen, Adina Amir, Vered Horwitz, Tamar Kadar
PURPOSE: Ocular injuries after exposure to sulfur mustard (SM) are characterized by acute corneal erosion and inflammation of the anterior segment that may be followed by delayed corneal neovascularization and epithelial defects, associated with limbal stem cell deficiency in part of the exposed eyes. This study aimed to further clarify the mechanism of the late injury by monitoring SM-induced cytological alterations in the ocular surface, in relation to the clinical symptoms, using impression cytology (IC)...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28582310/clinical-outcome-and-patients-satisfaction-study-after-otoplasty-using-hybrid-techniques-in-adult-patients
#9
Ji Yun Choi, Shin Chul Jung, Jonathan M Sykes
OBJECTIVES: There are limited data on the effect of otoplasty on health-related quality of life (HRQoL) in prominent ears. There are no data on the effect of otoplasty on Glasgow Benefit Inventory (GBI) of otoplasty using hybrid techniques in adult patients. METHODS: This study involved 28 patients who underwent otoplasty using combined procedures. We chose the GBI because it is a sensitive tool for detecting changes in health status following an intervention. Patients older than 13 years received the GBI, being retrospective well-validated questionnaires for measuring the effect of otorhinolaryngologic interventions, and particularly plastic surgery procedures, on HRQoL...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28581555/investigation-of-mechanisms-involved-in-postprandial-glycemia-and-insulinemia-attenuation-with-dietary-fibre-consumption
#10
Nikolay Repin, Brittney A Kay, Steve W Cui, Amanda J Wright, Alison M Duncan, H Douglas Goff
This work examines the mechanisms involved in the attenuation of postprandial glycemic and insulinemic responses associated with soluble dietary fibre (SDF) consumption. The effect of SDF, including yellow mustard mucilage, soluble flaxseed gum and fenugreek gum on in vitro amylolysis and maltose transport was studied. Furthermore, a human clinical trial was conducted to investigate the effect of SDF consumption on postprandial glycemic and insulinemic responses and gastric emptying, as estimated based on the absorption of paracetamol...
June 5, 2017: Food & Function
https://www.readbyqxmd.com/read/28573399/development-of-pr-genes-panel-for-screening-aphid-tolerant-cultivars-in-brassica-juncea
#11
R Sandeep Raj, Sonal V Thakur, Vora Shebhan Hussen, Madhvi N Joshi, Shradha Nand Tyagi, Snehal B Bagatharia
The exorbitant yield loss incurred by Indian farmers every year (10-90%) in rapeseed-mustard (Brassica juncea) is chiefly attributed to the progressive infestation of mustard fields by Lipaphis erysimi (Kalt.), a major insect pest belonging to the family of Homoptera. Currently there are no successful tolerant cultivars developed by conventional means in Brassica juncea with systemic plant responses in the form of direct or indirect defenses against aphid attack. Lack of specific methods for screening large numbers of genotypes required in breeding for selection of tolerant cultivars in mustard is one of the main causes of slow progress in developing resistant varieties of Brassica juncea...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28567239/bendamustine-and-its-role-in-the-treatment-of-unfit-patients-with-chronic-lymphocytic-leukaemia-a-perspective-review
#12
REVIEW
Othman Al-Sawaf, Paula Cramer, Valentin Goede, Michael Hallek, Natali Pflug
With a median age of 72 years at first diagnosis, chronic lymphocytic leukaemia (CLL) is a disease of the elderly. At this age, many patients cannot bear an intensive chemoimmunotherapy like fludarabine, cyclophosphamide and rituximab (FCR), and therapeutic decisions are commonly complicated by a high burden of accompanying comorbidities. Clinical trials, on the other hand, are mostly designed to include a far healthier and younger trial population, with a median age in most studies well below 70 years, leading to an insufficient reflection of clinical reality...
June 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/28562000/atomistic-approach-toward-selective-photocatalytic-oxidation-of-a-mustard-gas-simulant-a-case-study-with-heavy-chalcogen-containing-pcn-57-analogues
#13
Subhadip Goswami, Claire E Miller, Jenna L Logsdon, Cassandra T Buru, Yi-Lin Wu, David N Bowman, Timur Islamoglu, Abdullah M Asiri, Christopher J Cramer, Michael R Wasielewski, Joseph T Hupp, Omar K Farha
Here we describe the synthesis of two Zr-based benzothiadiazole- and benzoselenadiazole-containing metal-organic frameworks (MOFs) for the selective photocatalytic oxidation of the mustard gas simulant, 2-chloroethyl ethyl sulfide (CEES). The photophysical properties of the linkers and MOFs are characterized by steady-state absorption and emission, time-resolved emission, and ultrafast transient absorption spectroscopy. The benzoselenadiazole-containing MOF shows superior catalytic activity compared to that containing benzothiadiazole with a half-life of 3...
June 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28545160/-99m-tc-labeled-ngr-chlorambucil-conjugate-99m-tc-hynic-clb-c-ngr-for-targeted-chemotherapy-and-molecular-imaging
#14
Kusum Vats, Drishty Satpati, Rohit Sharma, Chandan Kumar, Haladhar D Sarma, Ashutosh Dash
Targeted delivery of chemotherapeutic drug at the tumor site enhances the efficacy with minimum systemic exposure. Towards this, drugs conjugated with peptides having affinity towards a particular molecular target are recognized as affective agents for targeted chemotherapy. Thus, in the present study, tumor-homing asparagine-glycine-arginine (NGR) peptide ligand was conjugated to DNA alkylating nitrogen mustard, chlorambucil (CLB). The peptide-drug conjugate (PDC), CLB-c(NGR), was radiolabeled with (99m) Tc-HYNIC core to trace its pharmacokinetics and biodistribution pattern...
May 25, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28542210/drosophila-dna-polymerase-theta-utilizes-both-helicase-like-and-polymerase-domains-during-microhomology-mediated-end-joining-and-interstrand-crosslink-repair
#15
Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey
Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB repair pathway named microhomology-mediated end joining (MMEJ) and is also a critical component for bypass or repair of ICLs in several organisms. Pol θ contains both polymerase and helicase-like domains that are tethered by an unstructured central region. While the role of the polymerase domain in promoting MMEJ has been studied extensively both in vitro and in vivo, a function for the helicase-like domain, which possesses DNA-dependent ATPase activity, remains unclear...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28540025/erratum-clinical-practice-guidelines-for-prevention-diagnosis-and-management-of-early-and-delayed-onset-ocular-injuries-due-to-mustard-gas-exposure
#16
(no author information available yet)
[This corrects the article on p. 65 in vol. 12, PMID: 28299009.].
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28537535/ethephon-increases-photosynthetic-nitrogen-use-efficiency-proline-and-antioxidant-metabolism-to-alleviate-decrease-in-photosynthesis-under-salinity-stress-in-mustard
#17
Noushina Iqbal, Shahid Umar, Tasir S Per, Nafees A Khan
Salinity is a serious threat to plant growth and development worldwide reducing agricultural productivity each year. Ethylene is an important phytohormone that affects plants performance under normal and abiotic stress conditions. In this study, role of ethylene was investigated in mitigating salinity stress (100 mM NaCl) effects on photosynthesis in mustard plants subjected to different nitrogen (N; 5 and 10 mM) levels. Plants under salinity stress exhibited marked increase in proline and reduced glutathione (GSH) content and activity of antioxidant enzymes...
May 24, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28530540/novel-n-mustard-benzimidazoles-benzothiazoles-hybrids-synthesis-and-anticancer-evaluation
#18
Dilip P Detroja, Tai-Lin Chen, Yi-Wen Lin, Tsai-Yi Yen, Ming-Hsi Wu, Tung-Hu Tsai, Krunal Maheriya, Rajesh Kakadiya, Te-Chang Lee, Anamik Shah, Tsann-Long Su
BACKGROUND: Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. OBJECTIVE: The purpose of this study is to design and synthesize compounds with a more favorable pharmacokinetic profile. METHODS: We synthesized a series of hybrid molecules comprising a phenyl N-mustard moiety and benzothiazole or benzimidazole scaffold linked via an ureido linker and evaluated their antitumor activity and plasma stability...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28528053/transcatheter-mustard-revision-using-endovascular-graft-prostheses
#19
Diego Porras, Dimitrios Mitsouras, Michael Steigner, Andreas A Giannopoulos, Tatiana Kelil, Audrey C Marshall, Matthew T Menard
We describe the use of percutaneously inserted, transcatheter endovascular graft prostheses to exclude large Mustard baffle leaks in a high-surgical-risk patient. We used 3-dimensional-printed models to determine feasibility and to plan the procedure. Telescoping thoracic and abdominal graft extensions were placed in the inferior and superior limbs of the systemic venous pathways. An atrial septal defect occluder device was also used to close a separate leak not covered by the endovascular graft prostheses...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527994/purification-and-characterization-of-a-protease-resistant-phytase-of-aspergillus-oryzae-sbs50-whose-properties-make-it-exceptionally-useful-as-a-feed-supplement
#20
Sapna, Bijender Singh
An extracellular phytase of Aspergillus oryzae SBS50 was purified to homogeneity using ammonium sulphate precipitation, ion-exchange and gel filtration chromatography. Purified phytase has a monomeric molecular mass of ∼80kDa exhibiting its optimal activity at pH 5.0 and 50°C with a T 1/2 of 300min at 50°C. Phytase of A. oryzae displayed broad substrate specificity with Vmax and Km values of 58.82μmol/ml/min and 1.14mM, respectively, for calcium phytate. Purity and homogeneity of the phytase was confirmed by high performance liquid chromatography and MALDI-TOF analysis revealed the identification of a peptide showing homology with acid phosphatase of Aspergillus oryzae RIB40...
May 17, 2017: International Journal of Biological Macromolecules
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