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https://www.readbyqxmd.com/read/28213888/transfusion-in-critical-care-a-uk-regional-audit-of-current-practice
#1
J O M Plumb, M G Taylor, E Clissold, M P W Grocott, R Gill
A consistent message within critical care publications has been that a restrictive transfusion strategy is non-inferior, and possibly superior, to a liberal strategy for stable, non-bleeding critically ill patients. Translation into clinical practice has, however, been slow. Here, we describe the degree of adherence to UK best practice guidelines in a regional network of nine intensive care units within Wessex. All transfusions given during a 2-month period were included (n = 444). Those given for active bleeding or within 24 h of major surgery, trauma or gastrointestinal bleeding were excluded (n = 148)...
February 18, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28213593/randomised-double-blind-parallel-group-placebo-controlled-study-to-evaluate-the-analgesic-efficacy-and-safety-of-vvz-149-injections-for-postoperative-pain-following-laparoscopic-colorectal-surgery
#2
Srdjan S Nedeljkovic, Darin J Correll, Xiaodong Bao, Natacha Zamor, Jose L Zeballos, Yi Zhang, Mark J Young, Johanna Ledley, Jessica Sorace, Kristen Eng, Carlyle P Hamsher, Rajivan Maniam, Jonathan W Chin, Becky Tsui, Sunyoung Cho, Doo H Lee
INTRODUCTION: In spite of advances in understanding and technology, postoperative pain remains poorly treated for a significant number of patients. In colorectal surgery, the need for developing novel analgesics is especially important. Patients after bowel surgery are assessed for rapid return of bowel function and opioids worsen ileus, nausea and constipation. We describe a prospective, double-blind, parallel group, placebo-controlled randomised controlled trial testing the hypothesis that a novel analgesic drug, VVZ -149, is safe and effective in improving pain compared with providing opioid analgesia alone among adults undergoing laparoscopic colorectal surgery...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28213493/development-of-the-critical-care-pharmacotherapy-trials-network
#3
Seth R Bauer, Prasad E Abraham, Jeffrey F Barletta, Gretchen M Brophy, Brian L Erstad, Jeffrey P Gonzales, Curtis E Haas, Robert MacLaren, Eric W Mueller, Keith M Olsen, Ishaq Lat
PURPOSE: The development of the Critical Care Pharmacotherapy Trials Network (CCPTN) as a model for practice-based pharmacotherapy research is described. SUMMARY: The CCPTN was formed in 2010 as a collaborative research network dedicated to scientific investigation in the field of critical care pharmacotherapy. The CCPTN organizational structure is consistent with many professional pharmacy and interdisciplinary organizations and organized into 3 primary domains: executive committee, working committees, and network membership...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28212883/nonlinear-relationship-between-extreme-temperature-and-mortality-in-different-temperature-zones-a-systematic-study-of-122-communities-across-the-mainland-of-china
#4
Chenzhi Wang, Zhao Zhang, Maigeng Zhou, Lingyan Zhang, Peng Yin, Wan Ye, Yi Chen
BACKGROUND: Numerous previous studies have reported that human health risk is extremely sensitive to temperature. Very few studies, however, have characterized the relationship between temperature and mortality in different temperature zones due to the previous conclusions deduced from a regional or administrative division. A research covers different temperature zones was indispensable to have a comprehensive understanding of regional ambient temperature effect on public health. METHODS: Based on the mortality dataset and meteorological variables of 122 communities in China from 2007 to 2012, a distributed lag nonlinear model (DLNM) was utilized to estimate the temperature effect on non-accidental mortality at the community level...
February 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28212062/community-health-agency-administrators-access-to-public-health-data-for-program-planning-evaluation-and-grant-preparation
#5
Sandra D Lane, Donna M Cashman, Robert H Keefe, Lutchmie Narine, Bradford Ducre, Sharon Chesna, Meghan Hall, David Oliver
The Affordable Care Act mandates that public health data be made available for community agency use. Having access to such data allows community agencies to tailor interventions, evaluations, and funding requests more effectively. This study, jointly undertaken by Syracuse University faculty and students with the New York State Perinatal Association, sought to understand community agencies' access to requests for governmental data, as well as to identify areas for improving data access. Results from this survey of administrators from 43 agencies in New York State found that only one-half of their requests for data were successful...
February 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28211119/cross-sectional-study-of-emergency-department-presentation-triage-categories-at-goondiwindi-hospital-and-their-effect-on-the-treatment-of-acute-emergencies
#6
Ashraf Saleh
OBJECTIVE: The objective of this study was to investigate the number and proportion of non-acute presentations to a district hospital emergency department in Goondiwindi, a rural Queensland town, both in the treatment of emergency cases and potential barriers patients have in seeing a medical practitioner in the general practice setting. DESIGN: Occasions of service to Goondiwindi Hospital were collated from administrative records according to Australasian Triage Scale categories and analysed by Student's t-test for monthly variations in triage category presentations...
February 17, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28210655/cost-of-outpatient-arthroscopic-anterior-cruciate-ligament-reconstruction-among-commercially-insured-patients-in-the-united-states-2005-2013
#7
Mackenzie M Herzog, Stephen W Marshall, Jennifer L Lund, Virginia Pate, Jeffrey T Spang
BACKGROUND: Despite the significance of anterior cruciate ligament (ACL) injuries, these conditions have been under-researched from a population-level perspective. It is important to determine the economic effect of these injuries in order to document the public health burden in the United States. PURPOSE: To describe the cost of outpatient arthroscopic ACL reconstruction and health care utilization among commercially insured beneficiaries in the United States. STUDY DESIGN: Economic and decision analysis; Level of evidence, 3...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28210454/managing-patients-taking-edoxaban-in-dentistry
#8
REVIEW
Adrian Curto, Daniel Curto, Jorge Sanchez
BACKGROUND: Anticoagulation therapy is used in several conditions to prevent or treat thromboembolism. A new group of oral anticoagulants with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. The Food and Drug Administration has approved edoxaban, dabigatran, rivaroxaban and apixaban. Their advantages include: predictable pharmacokinetics, drug interactions and limited food, rapid onset of action and short half-life...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209996/transient-cannabinoid-receptor-2-blockade-during-immunization-heightens-intensity-and-breadth-of-antigen-specific-antibody-responses-in-young-and-aged-mice
#9
Emmanuel Dotsey, Irina Ushach, Egest Pone, Rie Nakajima, Algis Jasinskas, Donovan A Argueta, Andrea Dillon, Nicholas DiPatrizio, Huw Davies, Albert Zlotnik, Peter D Crompton, Philip L Felgner
The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there is a gap in our understanding of the physiological factors that mediate innate and adaptive immune response to vaccines. The endocannabinoid (eCB) system is a critical modulator of homeostasis in vertebrates. Our results indicate that macrophages and dendritic cells produce the endocannabinoid, 2-arachidonoyl-sn-glycerol (2-AG) upon antigen activation...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208151/bacillus-calmette-gu%C3%A3-rin-confers-neuroprotection-in-a-murine-model-of-japanese-encephalitis
#10
Sahil Kulkarni, Sandeepan Mukherjee, Anupama Pandey, Ritwik Dahake, Usha Padmanabhan, Abhay S Chowdhary
OBJECTIVE: Japanese encephalitis (JE) is a debilitating disease caused by infection with the JE virus (JEV; family: Flaviviridae), which leaves neurological sequelae in survivors but more often leads to mortality. Neurodegeneration caused by inflammation is the primary pathology behind the clinical manifestation of encephalitis caused by JEV. Bacillus Calmette-Guérin (BCG) has been used in immunoprophylaxis for tuberculosis and in the adjuvant therapy of many malignancies, and has exhibited neuroprotective activities in experimental models of Parkinson and Alzheimer disease...
February 17, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28207688/transmission-of-zika-virus-haiti-october-12-2015-september-10-2016
#11
Ito Journel, Lesly L Andrécy, Dudley Metellus, Jean S Pierre, Rose Murka Faublas, Stanley Juin, Amber M Dismer, David L Fitter, Daniel Neptune, Marie José Laraque, Salomon Corvil, Manise Pierre, Josiane Buteau, Donald Lafontant, Roopal Patel, Jean Frantz Lemoine, David W Lowrance, Macarthur Charles, Jacques Boncy, Paul Adrien
Zika virus disease is caused by infection with a flavivirus with broad geographic distribution and is most frequently transmitted by the bite of an infected mosquito. The disease was first identified in the World Health Organization's Region of the Americas in 2015 and was followed by a surge in reported cases of congenital microcephaly in Brazil; Zika virus disease rapidly spread to the rest of the region and the Caribbean (1), including Haiti. Infection with the virus is associated with adverse fetal outcomes (1) and rare neurologic complications in adults...
February 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28207335/housing-assistance-programs-and-adult-health-in-the-united-states
#12
Andrew Fenelon, Patrick Mayne, Alan E Simon, Lauren M Rossen, Veronica Helms, Patricia Lloyd, Jon Sperling, Barry L Steffen
OBJECTIVES: To examine whether access to housing assistance is associated with better health among low-income adults. METHODS: We used National Health Interview Survey data (1999-2012) linked to US Department of Housing and Urban Development (HUD) administrative records (1999-2014) to examine differences in reported fair or poor health and psychological distress. We used multivariable models to compare those currently receiving HUD housing assistance (public housing, housing choice vouchers, and multifamily housing) with those who will receive housing assistance within 2 years (the average duration of HUD waitlists) to account for selection into HUD assistance...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28207078/emerging-infectious-diseases-animals-and-future-epidemics
#13
Herbert L DuPont
Emerging and reemerging infections have become prevalent in the United States since the 1970s, causing illness, death, and fear among the public. The published literature was reviewed to offer a perspective on risk factors for disease acquisition and to allow a prediction of the next microbial assault after Ebola and Zika. Four well-integrated factors likely will contribute simultaneously: animals colonized or infected by pathogens capable of human transmission, microbes recurrently changing their virulence, a growing number of susceptible people, and climatic and environmental factors encouraging disease transmission...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28206993/hemodynamic-effects-of-sodium-bicarbonate-administration
#14
A C Katheria, M K Brown, K Hassan, D M Poeltler, D A Patel, V K Brown, J B Sauberan
OBJECTIVE: To describe the hemodynamic changes that occur with sodium bicarbonate (NaHCO3) administration in premature neonates. STUDY DESIGN: This retrospective study included premature neonates 23 to 31+6 weeks of gestational age who underwent continuous cardiac and cerebral monitoring as participants in prospective trials at our institution, and who received NaHCO3 infused over 30 min in the first 24 h of life. Blood pressure (BP), heart rate, cardiac output (CO), SpO2 and cerebral oximetry (StO2) were captured every 2 s...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28202928/hospitalizations-due-to-selected-infections-caused-by-opportunistic-premise-plumbing-pathogens-oppp-and-reported-drug-resistance-in-the-united-states-older-adult-population-in-1991-2006
#15
Elena N Naumova, Alexander Liss, Jyotsna S Jagai, Irmgard Behlau, Jeffrey K Griffiths
The Flint Water Crisis-due to changes of water source and treatment procedures-has revealed many unsolved social, environmental, and public health problems for US drinking water, including opportunistic premise plumbing pathogens (OPPP). The true health impact of OPPP, especially in vulnerable populations such as the elderly, is largely unknown. We explored 10(8) claims in the largest US national uniformly collected data repository to determine rates and costs of OPPP-related hospitalizations. In 1991-2006, 617,291 cases of three selected OPPP infections resulted in the elderly alone of $0...
December 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28202925/public-health-aspects-of-the-world-s-largest-mass-gathering-the-2013-kumbh-mela-in-allahabad-india
#16
Satchit Balsari, P Gregg Greenough, Dhruv Kazi, Aaron Heerboth, Shraddha Dwivedi, Jennifer Leaning
India's Kumbh Mela remains the world's largest and longest mass gathering. The 2013 event, where participants undertook a ritual bath, hosted over 70 million Hindu pilgrims during 55 days on a 1936 hectare flood plain at the confluence of the Yamuna and Ganga Rivers. On the holiest bathing days, the population surged. Unlike other religious, cultural, and sports mass gatherings, the Kumbh Mela's administration cannot estimate or limit the participant number. The event created serious and uncommon public health challenges: initiating crowd safety measures where population density and mobility directly contact flowing bodies of water; providing water, sanitation, and hygiene to a population that frequently defecates in the open; and establishing disease surveillance and resource use measures within a temporary health delivery system...
December 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28202557/association-between-quantity-and-duration-of-snowfall-and-risk-of-myocardial-infarction
#17
Nathalie Auger, Brian J Potter, Audrey Smargiassi, Marianne Bilodeau-Bertrand, Clément Paris, Tom Kosatsky
BACKGROUND: Although aggregate data suggest a link between snowfall and myocardial infarction (MI), individual risk has yet to be assessed. We evaluated the association between quantity and duration of snowfall and the risk of MI using nonaggregated administrative health data. METHODS: We used a case-crossover study design to investigate the association between snowfall and hospital admission or death due to MI in the province of Quebec, Canada, between November and April during 1981-2014...
February 13, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28202262/cognitive-and-behavioral-effects-of-new-antiepileptic-drugs-in-pediatric-epilepsy
#18
REVIEW
Romina Moavero, Marta Elena Santarone, Cinzia Galasso, Paolo Curatolo
BACKGROUND: In pediatric epilepsy, neurodevelopmental comorbidities could be sometimes even more disabling than seizures themselves, therefore it is crucial for the clinicians to understand how to benefit these children, and to choose the proper antiepileptic drug for the treatment of epilepsy associated to a specific neurodevelopmental disorder. Aim of this paper is to discuss the potential impact on cognition and behavior of new and newest AEDs and to guide the choice of the clinicians for a targeted use in epilepsy associated with specific neurodevelopmental disorders...
February 12, 2017: Brain & Development
https://www.readbyqxmd.com/read/28197292/chlorthalidone-plus-amiloride-reduces-the-central-systolic-blood-pressure-in-stage-1-hypertension-patients
#19
Leticia Aparecida Barufi Fernandes, Elizabeth do Espirito Santo Cestario, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Flavio Danni Fuchs
BACKGROUND: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the importance of adequate control of the central compared to peripheral blood pressure...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28196951/understanding-repeated-non-attendance-in-health-services-a-pilot-analysis-of-administrative-data-and-full-study-protocol-for-a-national-retrospective-cohort
#20
Andrea E Williamson, David A Ellis, Philip Wilson, Ross McQueenie, Alex McConnachie
INTRODUCTION: Understanding the causes of low engagement in healthcare is a pre-requisite for improving health services' contribution to tackling health inequalities. Low engagement includes missing healthcare appointments. Serially (having a pattern of) missing general practice (GP) appointments may provide a risk marker for vulnerability and poorer health outcomes. METHODS AND ANALYSIS: A proof of concept pilot using GP appointment data and a focus group with GPs informed the development of missed appointment categories: patients can be classified based on the number of appointments missed each year...
February 14, 2017: BMJ Open
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