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https://www.readbyqxmd.com/read/28430165/treatments-for-latrodectism-a-systematic-review-on-their-clinical-effectiveness
#1
REVIEW
Nicole M Ryan, Nicholas A Buckley, Andis Graudins
Latrodectism or envenomation by widow-spiders is common and clinically significant worldwide. Alpha-latrotoxin is the mammalian-specific toxin in the venom that results in toxic effects observed in humans. Symptoms may be incapacitating and include severe pain that can persist for days. The management of mild to moderate latrodectism is primarily supportive while severe cases have variously been treated with intravenous calcium, muscle relaxants, widow-spider antivenom and analgesic opioids. The object of this systematic review is to examine the literature on the clinical effectiveness of past and current treatments for latrodectism...
April 21, 2017: Toxins
https://www.readbyqxmd.com/read/28429751/preclinical-study-of-raav2-strail-pharmaceutical-efficacy-biodistribution-and-safety-in-animals
#2
Q Ru, W Li, X Wang, S Zhang, L Chen, Y Zhang, Y Ge, Y Zu, Y Liu, D Zheng
The recombinant sTRAIL has been in clinical trial for various human malignancies. However, the half-life time of sTRAIL is very short, which might be an important factor influencing its clinical efficacy for cancer therapy. We previously reported the recombinant adeno-associated virus (AAV)-encoding sTRAIL95-281-mediated sTRAIL expression in vivo up to 8 months and suppressed tumor growth markedly in mouse xenografts. In the present study, we further evaluated the clinical potency for cancer gene therapy and the safety in mouse and non-human primates...
April 21, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28429629/developing-indicators-of-appropriate-and-inappropriate-end-of-life-care-in-people-with-alzheimer-s-disease-cancer-or-chronic-obstructive-pulmonary-disease-for-population-level-administrative-databases-a-rand-ucla-appropriateness-study
#3
Robrecht De Schreye, Dirk Houttekier, Luc Deliens, Joachim Cohen
BACKGROUND: A substantial amount of aggressive life-prolonging treatments in the final stages of life has been reported for people with progressive life-shortening conditions. Monitoring appropriate and inappropriate end-of-life care is an important public health challenge and requires validated quality indicators. AIM: To develop indicators of appropriate and inappropriate end-of-life care for people with cancer, chronic obstructive pulmonary disease or Alzheimer's disease, measurable with population-level administrative data...
April 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28429207/organizational-and-welfare-mode-of-breast-centers-network-a-survey-of-sicilian-radiologists
#4
Maria Adele Marino, Orazio Pennisi, Annalisa Donia, Carmelo Sofia, Claudio Guerra, Carmelo Privitera, Placido Romeo
The European Society of Breast Cancer Specialists has created quality indicators for breast units to establish the minimum standards of care for patients. In Italy, each region differs, indeed, in terms of health care and services warranted to patients suffering from breast cancer. Since Sicilian Regional Administration today is still disregarding implementation of the provisions contained in the proposal of the Ministry of Health entitled "Guidelines on Organizational and Health Care Methods of Breast Centers Network" in November 2015 the Sicilian Regional Group of the Italian Society of Radiology (SIRM) decided to carry out a survey to see the position of the Sicilian Healthcare System and define the gap to bridge over...
April 20, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28428878/immunization-dropout-rate-and-data-quality-among-children-12-23-months-of-age-in-ghana
#5
Benjamin Baguune, Joyce Aputere Ndago, Martin Nyaaba Adokiya
BACKGROUND: Immunization against diseases is one of the most important public health interventions with cost effective means to preventing childhood morbidity, mortality and disability. However, a proportion of children particularly in Africa are not fully immunized with the recommended vaccines. Thus, many children are still susceptible to the Expanded Program on Immunization (EPI) targeted diseases. The objective of this study was to determine the immunization dropout rate and data quality among children aged 12-23 months in Techiman Municipality, Ghana...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28428122/challenges-in-the-management-of-chagas-disease-in-latin-american-migrants-in-europe
#6
REVIEW
B Monge-Maillo, R López-Vélez
 Chagas disease (CD) is endemic in Latin America. Due to migration, the infection has crossed borders and it is estimated that 68 000-120 000 people with CD are currently living in Europe and 30% of them may develop visceral involvement. However, up to 90% of CD cases in Europe remain undiagnosed. The challenges which have to be overcome in CD are related to screening, diagnostic tools and therapeutic management in non-endemic countries. AIMS : The aim of this review is to highlight how healthcare management for Latin American migrants with CD in Europe may be improved...
April 17, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28427875/easl-2017-clinical-practice-guidelines-on-the-management-of-hepatitis-b-virus-infection
#7
Pietro Lampertico, Kosh Agarwal, Thomas Berg, Maria Buti, Harry L A Janssen, George Papatheodoridis, Fabien Zoulim, Frank Tacke
Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors including vaccination policies and migration. This Clinical Practice Guideline presents updated recommendations for the optimal management of HBV infection. Chronic HBV infection can be classified into five phases: (I) HBeAg-positive chronic infection, (II) HBeAg-positive chronic hepatitis, (III) HBeAg-negative chronic infection, (IV) HBeAg-negative chronic hepatitis and (V) HBsAg-negative phase...
April 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28427448/capture-recapture-methodology-to-study-rare-conditions-using-surveillance-data-for-fragile-x-syndrome-and-muscular-dystrophy
#8
Michael G Smith, Julie Royer, Joshua Mann, Suzanne McDermott, Rodolfo Valdez
BACKGROUND: Rare conditions can be catastrophic for families and the implications for public health can be substantial. Our study compared basic surveillance through active medical record review with a linked administrative data file to assess the number of cases of two rare conditions, fragile X syndrome (FXS) and muscular dystrophy (MD) in a population. METHODS: Two methods of data collection were used to collect information from five counties comprising two standard metropolitan statistical areas of South Carolina...
April 21, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28427137/-bibliometric-analysis-of-scientific-articles-on-epidemiological-study-of-burns-in-china
#9
W F Cheng, Z A Shen, D X Zhao, D W Li, Y R Shang
Objective: To analyze the current status of epidemiological study of burns in China, and to explore the related strategies. Methods: Retrospective or cross-sectional scientific articles in Chinese or English on epidemiological study of burns in China published from January 2005 to December 2015 were systemically retrieved from 4 databases. The databases include PubMed, Embase, China Biology Medicine disc, and Chinese Journals Full-text Database. From the results retrieved, data with regard to publication year, journal distribution, number of institutions participated in the study, affiliation of the first author and its location, and admission time span and age of patients in all the scientific articles were collected...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28427070/practical-lessons-from-protocol-t-for-the-management-of-diabetic-macular-edema
#10
Lekha Mukkamala, Neelakshi Bhagat, Marco Zarbin
PURPOSE: To review the results of Diabetic Retinopathy Clinical Research Network Protocol T, as applied to clinical practice. METHODS: Review of major publications reporting the results of Protocol T, a randomized single-masked (in year-1 only), multicenter clinical trial comparing aflibercept, bevacizumab, and ranibizumab as treatment option for center-involving diabetic macular edema (DME). The main outcome measures were change in visual acuity (VA), central subfield thickness (CST) on optical coherence tomography, cost effectiveness, burden of care, and safety...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28426309/lgbtq-health-surveillance-data%C3%A2-%C3%A2-power
#11
Randall L Sell
Despite decades of research and advocacy, sexual and gender minorities are still not equitably included in health research and surveillance in the United States. In 1990, as I was beginning graduate school, I wrote on a piece of paper "Data = Power." This was my take on ACT UP's (AIDS Coalition to Unleash Power) "Silence = Death." I created this personal motto because I had been working in the late 1980s on evaluations of some of the earliest federally funded HIV/AIDS prevention programs while attending ACT UP's first demonstration at the Food and Drug Administration in 1988 and attending its action to "Storm the NIH" (National Institutes of Health) in 1990...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28426306/machine-learning-for-social-services-a-study-of-prenatal-case-management-in-illinois
#12
Ian Pan, Laura B Nolan, Rashida R Brown, Romana Khan, Paul van der Boor, Daniel G Harris, Rayid Ghani
OBJECTIVES: To evaluate the positive predictive value of machine learning algorithms for early assessment of adverse birth risk among pregnant women as a means of improving the allocation of social services. METHODS: We used administrative data for 6457 women collected by the Illinois Department of Human Services from July 2014 to May 2015 to develop a machine learning model for adverse birth prediction and improve upon the existing paper-based risk assessment. We compared different models and determined the strongest predictors of adverse birth outcomes using positive predictive value as the metric for selection...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28426297/note-from-the-editor-in-chief-who-wants-to-exclude-older-lgbt-persons-from-public-health-surveillance
#13
Alfredo Morabia
It is sobering to publish Sell's call for every federal survey to include questions about sexual orientation and gender identity precisely when the Trump Administration excludes such questions from the proposed 2017 National Survey of Older Americans Act Participants (NSOAAP) conducted by the Administration for Community Living (ACL) in the Department of Health and Human Services. In particular, NSOAAP question DE1a, introduced in 2014, asked "Which of the following best represents how you think of yourself? Lesbian or Gay; Straight, that is, not lesbian or gay; Bisexual; Something else; Refused; Don't know...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28425681/schedules-of-controlled-substances-temporary-placement-of-six-synthetic-cannabinoids-5f-adb-5f-amb-5f-apinaca-adb-fubinaca-mdmb-chmica-and-mdmb-fubinaca-into-schedule-i-temporary-scheduling-order
#14
(no author information available yet)
The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], and their optical, positional, and geometric isomers, salts, and salts of isomers into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act...
April 10, 2017: Federal Register
https://www.readbyqxmd.com/read/28425480/efficient-cns-targeting-in-adult-mice-by-intrathecal-infusion-of-single-stranded-aav9-gfp-for-gene-therapy-of-neurological-disorders
#15
K Bey, C Ciron, L Dubreil, J Deniaud, M Ledevin, J Cristini, V Blouin, P Aubourg, M-A Colle
Adeno-associated virus (AAV) gene therapy constitutes a powerful tool for the treatment of neurodegenerative diseases. While AAVs are generally administered systemically to newborns in preclinical studies of neurological disorders, in adults the maturity of the blood-brain barrier (BBB) must be considered when selecting the route of administration. Delivery of AAVs into the cerebrospinal fluid (CSF) represents an attractive approach to target the central nervous system (CNS) and bypass the BBB. In this study, we investigated the efficacy of intra-CSF delivery of a single-stranded (ss) AAV9-CAG-GFP vector in adult mice via intracisternal (iCist) or intralumbar (it-Lumb) administration...
April 20, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28425000/medical-care-screening-and-regularization-of-sub-saharan-irregular-migrants-affected-by-hepatitis-b-in-france-and-italy
#16
Cecilia Santilli
Both in France and in Italy hepatitis B is present mostly among the migrant population coming from sub-Saharan Africa and mainly among those migrants having a poor socio-economic background. This article is aimed at assaying the impact of public policies adopted by France and Italy for migrants' health on the treatment of migrants with HBV. The article is based on semi-structured interviews conducted with 30 immigrant adults taken into care by two associations dealing with medical, psychological and social issues of immigrants applying for a residence permit, mainly asylum seekers...
April 20, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28422962/docosahexaenoic-acid-blocks-progression-of-western-diet-induced-nonalcoholic-steatohepatitis-in-obese-ldlr-mice
#17
Kelli A Lytle, Carmen P Wong, Donald B Jump
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a major public health concern in western societies. Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, is characterized by hepatic steatosis, inflammation, oxidative stress and fibrosis. NASH is a risk factor for cirrhosis and hepatocellular carcinoma. NASH is predicted to be the leading cause of liver transplants by 2020. Despite this growing public health concern, there remain no Food and Drug Administration (FDA) approved NASH treatments...
2017: PloS One
https://www.readbyqxmd.com/read/28422621/historic-leadership-one-courageous-school-nurse-s-heroic-journey-part-3
#18
Ellen F Johnsen, Katherine J Pohlman
School nursing practice establishes itself in the midst of both education and nursing philosophies, ethics, standards, laws, and regulations. Treading these two worlds is difficult at times and requires that a school nurse possess a strong foundational knowledge base, seek professional collaboration, and navigate conflicting professional demands in order to promote student and public safety. This article is Part 3 of a four-part series that recounts the inspiring story of a school nurse, Ellen Johnsen, who did just that back in the 1980s in Broken Arrow, Oklahoma...
May 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28421883/ctsa-institution-responses-to-proposed-common-rule-changes-did-they-get-what-they-wanted
#19
Suzanne M Rivera, Lisa Nichols, Lois Brako, Genevieve Croft, Toni Russo, Tara Tran
In 2015, the U.S. Department of Health and Human Services (HHS) and 15 other federal departments and agencies proposed revisions to the Federal Policy for the Protection of Human Subjects. In this Notice of Proposed Rulemaking (NPRM), the departments sought to strengthen, modernize, and make more effective human subjects regulations while reducing administrative burden, delay, and ambiguity. We reviewed public comments from National Institutes of Health (NIH)-funded Clinical and Translational Science Awards (CTSA) institutions on key provisions of the NPRM to understand how the proposed changed were received at research-intensive institutions...
April 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28421776/drugs-via-enteral-feeding-tubes-in-inpatients-dispersion-analysis-and-safe-use-of-dispensers
#20
Milena Pontes Portela Beserra, Cristiani Lopes Capistrano Gonçalves De Oliveira, Mileyde Ponte Portela, Marcos Venícios de Oliveira Lopes, Marta Maria de França Fonteles
OBJECTIVE: This study aimed to improve knowledge about drug administration through enteral feeding tubes (EFTs) in order to minimize efficacy and safety problems. MATERIAL AND METHODS: The study was performed in a public secondary care hospital with level II accreditation by the National Accreditation Organization (Organização Nacional de Acreditação ONA), in Fortaleza, Ceará, north-eastern Brazil. RESULTS: One hundred and eight oral solid medications that could be administered through EFTs and were not available in liquid forms were evaluated via transformation of their solid dosage forms into liquid forms...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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