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https://www.readbyqxmd.com/read/28226436/optimizing-rtms-treatment-of-a-balance-disorder-with-eeg-neural-synchrony-and-functional-connectivity
#1
Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Han Yuan, Yoon-Hee Cha, Diamond Urbano, Lei Ding, Guofa Shou
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for its potential treatment effects across diverse mental disorders. However, the treatment effect is elusive and the rate of positive responders is not high, which make it in great demand of optimizing rTMS protocols to improve the treatment effects and the rate. In this regard, neural activity guided optimization has indicated great potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28007644/association-between-htr1b-alleles-and-suicidal-ideation-in-individuals-with-major-depressive-disorder
#2
Wei-Tsung Kao, Ming-Chang Yang, For-Wey Lung
Serotonin receptors, also known as 5-hydroxytryptamine receptors (HTRs), play a role in individuals' vulnerability to major depressive disorders (MDDs) and/or suicide attempts. In the first part of the study, we recruited 789 Taiwanese participants, which included 285 MDD patients, 191 MDD patients with a history of suicide attempts (MS), and 313 controls. The three groups were genotyped to identify HTR single nucleotide polymorphisms (SNPs) and we analyzed the correlations among the three groups. In the second part of the study, which involved a functional test of HTR1B allelic and haplotype variants, another 113 MDD patients were recruited...
December 19, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27919003/altered-patterns-of-directed-connectivity-within-the-reading-network-of-dyslexic-children-and-their-relation-to-reading-dysfluency
#3
Gojko Žarić, João M Correia, Gorka Fraga González, Jurgen Tijms, Maurtis W van der Molen, Leo Blomert, Milene Bonte
Reading is a complex cognitive skill subserved by a distributed network of visual and language-related regions. Disruptions of connectivity within this network have been associated with developmental dyslexia but their relation to individual differences in the severity of reading problems remains unclear. Here we investigate whether dysfunctional connectivity scales with the level of reading dysfluency by examining EEG recordings during visual word and false font processing in 9-year-old typically reading children (TR) and two groups of dyslexic children: severely dysfluent (SDD) and moderately dysfluent (MDD) dyslexics...
February 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/27730651/management-of-mal-de-debarquement-syndrome-as-vestibular-migraines
#4
Yaser Ghavami, Yarah M Haidar, Kasra N Ziai, Omid Moshtaghi, Jay Bhatt, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: Mal de debarquement syndrome (MdDS) is a balance disorder that typically starts after an extended exposure to passive motion, such as a boat or plane ride. Management is typically supportive (e.g. physical therapy), and symptoms that persist beyond 6 months have been described as unlikely to remit. This study was conducted to evaluate the response of patients with MdDS to management with migraine prophylaxis, including lifestyle changes and medical therapy. STUDY DESIGN: Prospective review...
October 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27660449/the-interactive-effects-of-ketamine-and-magnesium-upon-depressive-like-pathology
#5
Sara Razmjou, Darcy Litteljohn, Chris Rudyk, Shuaib Syed, Melanie Clarke, Rowan Pentz, Zach Dwyer, Shawn Hayley
Approximately one-third of patients with major depressive disorders (MDDs) are resistant to current treatment methods, and the majority of cases relapse at some point during therapy. This has resulted in novel treatments being adopted, including subanesthetic doses of ketamine, which affects aberrant neuroplastic circuits, glutamatergic signaling, and the production of brain-derived neurotrophic factor. Ketamine rapidly relieves depressive symptoms in treatment-resistant major depressive disorder patients with effects that last for up to 2 weeks even after a single administration...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27638086/mal-de-d%C3%A3-barquement-syndrome
#6
REVIEW
T C Hain, M Cherchi
Mal de débarquement syndrome (MdDS) is typified by a prolonged rocking sensation - for a month or longer - that begins immediately following a lengthy exposure to motion. The provoking motion is usually a sea voyage. About 80% of MdDS sufferers are women, and most of them are middle-aged. MdDS patients are troubled by more migraine headaches than controls. Unlike dizziness caused by vestibular disorders or motion sickness, the symptoms of MdDS usually improve with re-exposure to motion. The long duration of symptoms - a month or more - distinguishes MdDS from land-sickness...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27540294/exercise-is-medicine-for-patients-with-major-depressive-disorders-but-only-if-the-pill-is-taken
#7
Markus Gerber, Edith Holsboer-Trachsler, Uwe Pühse, Serge Brand
Major depressive disorders (MDDs) are a widespread and burdensome mental illness associated with a high comorbidity with other conditions and a significantly reduced life expectancy compared to the general population. Therefore, targeted actions are needed to improve physical health in people with MDDs, in addition to ongoing efforts to enhance psychological well-being. Meanwhile, the positive effects of exercise training on the treatment of MDDs are well documented, while compelling evidence exists that exercise interventions can improve cardiorespiratory fitness in clinically meaningful ways...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27484677/optimization-of-routine-monitoring-of-workers-exposed-to-plutonium-aerosols
#8
Estelle Davesne, Benoit Quesne, Antoine De Vita, Eric Chojnacki, Eric Blanchardon, Didier Franck
In case of incidental confinement failure, mixed oxide (MOX) fuel preparation may expose workers to plutonium aerosols. Due to its potential toxicity, occupational exposure to plutonium compounds should be kept as low as reasonably achievable. To ensure the absence of significant intake of radionuclides, workers at risk of internal contamination are monitored by periodic bioassay planned in a routine monitoring programme. From bioassay results, internal dose may be estimated. However, accurate dose calculation relies on known exposure conditions, which are rarely available when the exposure is demonstrated by routine monitoring only...
October 2016: Annals of Occupational Hygiene
https://www.readbyqxmd.com/read/27478503/joint-analysis-of-multiple-high-dimensional-data-types-using-sparse-matrix-approximations-of-rank-1-with-applications-to-ovarian-and-liver-cancer
#9
Gordon Okimoto, Ashkan Zeinalzadeh, Tom Wenska, Michael Loomis, James B Nation, Tiphaine Fabre, Maarit Tiirikainen, Brenda Hernandez, Owen Chan, Linda Wong, Sandi Kwee
BACKGROUND: Technological advances enable the cost-effective acquisition of Multi-Modal Data Sets (MMDS) composed of measurements for multiple, high-dimensional data types obtained from a common set of bio-samples. The joint analysis of the data matrices associated with the different data types of a MMDS should provide a more focused view of the biology underlying complex diseases such as cancer that would not be apparent from the analysis of a single data type alone. As multi-modal data rapidly accumulate in research laboratories and public databases such as The Cancer Genome Atlas (TCGA), the translation of such data into clinically actionable knowledge has been slowed by the lack of computational tools capable of analyzing MMDSs...
2016: BioData Mining
https://www.readbyqxmd.com/read/27428086/cortisol-dhea-ratio-and-hippocampal-volume-a-pilot-study-in-major-depression-and-healthy-controls
#10
Rowen O Jin, Sara Mason, Synthia H Mellon, Elissa S Epel, Victor I Reus, Laura Mahan, Rebecca L Rosser, Christina M Hough, Heather M Burke, Susanne G Mueller, Owen M Wolkowitz
Structural imaging studies investigating the relationship between hippocampal volume (HCV) and peripheral measures of glucocorticoids (GCs) have produced conflicting results in both normal populations and in individuals with MDD, raising the possibility of other modulating factors. In preclinical studies, dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS; together abbreviated, DHEA(S)) have been shown to antagonize the actions of GCs on the central nervous system. Therefore, considering the relationship of HCV to both of these hormones simultaneously may be important, although it has rarely been done in human populations...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27427515/clinical-impact-of-the-interstitial-lung-disease-multidisciplinary-service
#11
Helen E Jo, Ian N Glaspole, Kovi C Levin, Samuel R McCormack, Annabelle M Mahar, Wendy A Cooper, Rhoda Cameron, Samantha J Ellis, Alice M Cottee, Susanne E Webster, Lauren K Troy, Paul J Torzillo, Peter Corte, Karen M Symons, Nicole Taylor, Tamera J Corte
BACKGROUND AND OBJECTIVE: Multidisciplinary discussions (MDDs) have been shown to improve diagnostic accuracy in interstitial lung disease (ILD) diagnosis. However, their clinical impact on patient care has never been clearly demonstrated. We describe the effect that an ILD multidisciplinary service has upon the diagnosis and management of patients with suspected ILD. METHODS: Patients at two specialized centres with suspected ILD underwent ILD multidisciplinary team review (ILD-MDT) (standard ILD clinic visit and diagnostic review at ILD-MDD)...
July 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27382293/effect-of-adjuvant-sleep-hygiene-psychoeducation-and-lorazepam-on-depression-and-sleep-quality-in-patients-with-major-depressive-disorders-results-from-a-randomized-three-arm-intervention
#12
Alireza Rahimi, Mohammad Ahmadpanah, Farshid Shamsaei, Fatemeh Cheraghi, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
BACKGROUND: Sleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP-LOR). METHODS: A total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27364694/mean-diffusivity-of-basal-ganglia-and-thalamus-specifically-associated-with-motivational-states-among-mood-states
#13
Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima
Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions...
June 30, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27199505/rumination-and-cognitive-distraction-in-major-depressive-disorder-an-examination-of-respiratory-sinus-arrhythmia
#14
Joelle LeMoult, K Lira Yoon, Jutta Joormann
Difficulty regulating emotions following stressful events is a hallmark of Major Depressive Disorder (MDD). Although individuals' ability to regulate their emotions is believed to have direct consequences for both emotional and physical wellbeing, few studies have examined the cardiovascular effects of different emotion regulation strategies in MDD. To the best of our knowledge, the current study is the first to examine the effects of two emotion regulation strategies, cognitive distraction and rumination, on both self-reported sadness and respiratory sinus arrhythmia (RSA) in individuals with MDD and healthy controls (CTLs)...
March 2016: Journal of Psychopathology and Behavioral Assessment
https://www.readbyqxmd.com/read/27176615/double-blind-sham-controlled-crossover-trial-of-repetitive-transcranial-magnetic-stimulation-for-mal-de-debarquement-syndrome
#15
Yoon-Hee Cha, Choi Deblieck, Allan D Wu
OBJECTIVE: To determine whether the chronic rocking dizziness that occurs in Mal de Debarquement Syndrome (MdDS) can be suppressed with repetitive transcranial magnetic stimulation (rTMS) beyond the treatment period. METHODS: We performed a prospective randomized double-blind sham controlled crossover trial of 5-days of rTMS utilizing high frequency (10 Hz) stimulation over the left dorsolateral prefrontal cortex (DLPFC). RESULTS: Eight right-handed women (44...
July 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27121431/expected-emotional-usefulness-and-emotional-preference-in-individuals-with-major-depressive-disorder
#16
Sunkyung Yoon, Seung-Hwan Lee, Hyang Sook Kim
OBJECTIVE: Previous studies indicate that emotion regulation problems in major depressive disorder (MDD) may be caused by difficulties in preferring useful emotions according to their goals. We investigated expected emotional usefulness and emotional preference in individuals with MDD (MDDs) and healthy controls (HCs). METHODS: Participants were given an interpersonal scenario with two different goals (confrontation and collaboration) and rated their willingness to participate in emotion-provoking activities and the expected usefulness of a particular emotion...
May 31, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27117283/randomized-single-blind-sham-controlled-trial-of-adjunctive-home-based-tdcs-after-rtms-for-mal-de-debarquement-syndrome-safety-efficacy-and-participant-satisfaction-assessment
#17
Yoon-Hee Cha, Diamond Urbano, Nicole Pariseau
BACKGROUND: Mal de debarquement syndrome is a medically refractory disorder characterized by chronic rocking dizziness that occurs after exposure to passive motion. Repetitive transcranial magnetic stimulation (rTMS) can acutely suppress the rocking dizziness but treatment options that extend the benefit of rTMS are needed. OBJECTIVES: 1) To determine whether transcranial direct current stimulation (tDCS) added after rTMS can extend the benefit of rTMS; 2) to determine whether participants can safely perform tDCS at home...
July 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27107553/modeling-structural-transitions-from-the-periplasmic-open-state-of-lactose-permease-and-interpretations-of-spin-label-experiments
#18
Xiaohong Zhuang, Jeffery B Klauda
Lactose permease of E. coli (LacY) is a secondary active transporter (SAT) that belongs to the major facilitator superfamily (MFS). Experimental structures of the cytoplasmic-open and more recently occluded-like structure have been determined, however, the crystal structure of LacY in the periplasmic-open state is still not available. The periplasmic-open LacY structure is important for understanding complete proton/sugar transport process of LacY as well as other similar SAT proteins. Previously, a structural model of periplasmic-open LacY has been obtained through a two-step hybrid implicit-explicit (IM-EX) simulation method (JMB404: 506)...
July 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27070410/serum-bdnf-levels-before-and-after-the-development-of-mood-disorders-a-case-control-study-in-a-population-cohort
#19
K Ihara, H Yoshida, P B Jones, M Hashizume, Y Suzuki, H Ishijima, H K Kim, T Suzuki, M Hachisu
Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case-control study nested in a cohort of 1276 women aged 75-84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history)...
April 12, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26796237/neural-connectivity-of-alexithymia-specific-association-with-major-depressive-disorder
#20
Nerissa S P Ho, Michael M C Wong, Tatia M C Lee
BACKGROUND: Alexithymia has been frequently associated with major depression disorders (MDD). Yet little is known about the exact relationship of alexithymia and MDD. In order to explore this subject matter, the neural connectivity associated with alexithymia in people with MDD and matched nonclinical controls were compared. METHODS: Twenty-two females diagnosed with first-episode MDD and twenty-one matched nonclinical controls were MRI brain-scanned with diffusion-tensor-imaging and resting-state-functional-imaging methods, and self-reported the Chinese 20-item Toronto Alexithymia Scale...
March 15, 2016: Journal of Affective Disorders
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