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https://www.readbyqxmd.com/read/29718725/bispecific-antibodies-anti-mpeg-anti-her2-for-active-tumor-targeting-of-docetaxel-dtx-loaded-mpegylated-nanocarriers-to-enhance-the-chemotherapeutic-efficacy-of-her2-overexpressing-tumors
#1
Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang, Ming-Thau Sheu
Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (Lsb MDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX. DTX-loaded mPEGylated Lsb MDDs formulations were prepared using lecithin/DSPE-PEG(2K or 5K) nanosuspensions to hydrate the thin film, and then they were subjected to ultrasonication. Two BsAbs (anti-mPEG/anti-DNS or anti-HER2) were simply mixed with the Lsb MDDs to form BsAbs-Lsb MDDs formulations, respectively, referred as the DNS-Lsb MDDs and HER2-Lsb MDDs...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29710288/the-drug-overdose-epidemic-and-deceased-donor-transplantation-in-the-united-states-a-national-registry-study
#2
Christine M Durand, Mary G Bowring, Alvin G Thomas, Lauren M Kucirka, Allan B Massie, Andrew Cameron, Niraj M Desai, Mark Sulkowski, Dorry L Segev
Background: The epidemic of drug overdose deaths in the United States has led to an increase in organ donors. Objective: To characterize donors who died of overdose and to analyze outcomes among transplant recipients. Design: Prospective observational cohort study. Setting: Scientific Registry of Transplant Recipients, 1 January 2000 to 1 September 2017. Participants: 138 565 deceased donors; 337 934 transplant recipients at 297 transplant centers...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29705213/multi-kinetic-release-of-benznidazole-loaded-multiparticulate-drug-delivery-systems-based-on-polymethacrylate-interpolyelectrolyte-complexes
#3
Mónica C García, Marisa Martinelli, Nicolás E Ponce, Liliana M Sanmarco, M Pilar Aoki, Rubén H Manzo, Alvaro F Jimenez-Kairuz
Interpolyelectrolyte complexes (IPEC) formulated as multiparticulate drug delivery systems (MDDS) are interesting carriers to improve drug' performance. Benznidazole (BZ) is the first-line drug for Chagas treatment; however, it presents side effects and toxicity, conditioning its efficacy and safety. The goal of this work was to obtain novel MDDS composed by IPEC based on different polymethacrylate carriers loaded with BZ and to investigate in vitro drug delivery performance for oral administration. Physicochemical characterizations were studied and preclinical studies in a murine model of acute Chagas disease were also performed...
April 26, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29614848/outcomes-of-mitochondrial-derived-diseases-a-single-center-experience
#4
Sahin Erdol, Halil Saglam
BACKGROUND: The purpose of this study is to help elucidate which part of the mitochondria is causing a problem through anamnesis, physical examination, and routine biochemical tests in the event of a suspected mitochondrial disease case. METHODS: The data were obtained retrospectively from the medical records of 75 cases; the mitochondrial-derived disease (MDD) cases were observed in our center from 2011 to 2017. RESULTS: The most commonly observed MDDs were oxidative phosphorylation disorders at 44%, followed by fatty acid oxidation disorder at 40%, pyruvate metabolism disorder at 12%, and ketone metabolism disorder at 4%, respectively...
March 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29569983/the-development-of-a-novel-high-precision-major-depressive-disorder-screening-system-using-transient-autonomic-responses-induced-by-dual-mental-tasks
#5
Takemi Matsui, Toshikazu Shinba, Guanghao Sun
12.6% of major depressive disorder (MDD) patients have suicide intent, while it has been reported that 43% of patients did not consult their doctors for MDD, automated MDD screening is eagerly anticipated. Recently, in order to achieve automated screening of MDD, biomarkers such as multiplex DNA methylation profiles or physiological method using near infra-red spectroscopy (NIRS) have been studied, however, they require inspection using 96-well DNA ELIZA kit after blood sampling or significant cost. Using a single-lead electrocardiography (ECG), we developed a high-precision MDD screening system using transient autonomic responses induced by dual mental tasks...
March 23, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29483889/perspective-stepping-stones-to-unraveling-the-pathophysiology-of-mal-de-debarquement-syndrome-with-neuroimaging
#6
Viviana Mucci, Yoon-Hee Cha, Floris L Wuyts, Angelique Van Ombergen
Mal de debarquement syndrome (MdDS) is a neurological condition typically characterized by a sensation of motion, which in most cases manifests after disembarking from a vehicle (e.g., boat, plane, and car). However, the same symptoms can also occur spontaneously. Two main theories of the pathophysiology of MdDS are briefly summarized here. In this perspective, we aimed to report the most recent findings on neuroimaging studies related to MdDS, as well as to suggest further potential research questions that could be addressed with the use of neuroimaging techniques...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29459843/hypothesis-the-vestibular-and-cerebellar-basis-of-the-mal-de-debarquement-syndrome
#7
Bernard Cohen, Sergei B Yakushin, Catherine Cho
The Mal de Debarquement syndrome (MdDS) generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary to the incessant sensation of movement. We previously suggested that the illness can be attributed to maladaptation of the velocity storage integrator in the vestibular system, but the actual neural mechanisms driving the MdDS are unknown...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29453169/randomized-eeg-functional-brain-networks-in-major-depressive-disorders-with-greater-resilience-and-lower-rich-club-coefficient
#8
Minghui Zhang, Haiyan Zhou, Liqing Liu, Lei Feng, Jie Yang, Gang Wang, Ning Zhong
OBJECTIVE: Some studies have shown that the functional electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) networks in those with major depressive disorders (MDDs) have an abnormal random topology. In this study we aimed to further investigate the characteristics of the randomized functional brain networks in MDDs by examining resting-state scalp-EEG data. METHODS: Based on the methods of independent component analysis (ICA) and graph theoretic analysis, the abnormalities in the power spectral density (PSD) functional brain networks were compared between 13 MDDs and 13 matched healthy controls (HCs)...
April 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29324522/how-does-repetitive-transcranial-magnetic-stimulation-influence-the-brain-in-depressive-disorders-a-review-of-neuroimaging-magnetic-resonance-imaging-studies
#9
Simon Taïb, Christophe Arbus, Anne Sauvaget, Marie Sporer, Laurent Schmitt, Antoine Yrondi
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) is a nonpharmacological technique used to stimulate the brain. It is a safe and proven alternative tool to treat resistant major depressive disorders (MDDs). Neuroimaging studies suggest a wide corticolimbic network is involved in MDDs. We researched observable changes in magnetic resonance imaging induced by rTMS to clarify the operational mechanism. METHODS: A systematic search of the international literature was performed using PubMed and Embase, using papers published up to January 1, 2017...
January 11, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29305644/mal-de-debarquement-syndrome-a-survey-on-subtypes-misdiagnoses-onset-and-associated-psychological-features
#10
V Mucci, J M Canceri, R Brown, M Dai, S Yakushin, S Watson, A Van Ombergen, V Topsakal, P H Van de Heyning, F L Wuyts, C J Browne
INTRODUCTION: Mal de Debarquement Syndrome (MdDS) is a neurological condition typically characterized by a sensation of motion, that persists longer than a month following exposure to passive motion (e.g., cruise, flight, etc.). The most common form of MdDS is motion triggered (MT). However, recently it has been acknowledged that some patients develop typical MdDS symptoms without an apparent motion trigger. These cases are identified here as spontaneous or other onset (SO) MdDS. This study aimed to address similarities and differences between the MdDS subtypes...
March 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29283101/the-reliability-and-validity-of-dokuz-eyl%C3%A3-l-university-meniere-s-disease-disability-scale
#11
Başak Mutlu, Günay Kırkım, Serpil Mungan Durankaya, Selhan Gürkan, Tahsin Oğuz Başokçu, Enis Alpin Güneri
OBJECTIVE: Ménière's Disease (MD) is a chronic, non-life threatening inner ear disease, with attacks of disabling vertigo, progressive hearing loss, and tinnitus as the major symptoms. All three symptoms, separately or in combination, cause great distress and have a considerable impact on the quality of life of the patients. The aims of this study were to develop a disease-specific quality of life survey for patients with MD and to analyze the relationships between the audiovestibular findings and the survey...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29185233/estimating-prevalence-and-healthcare-utilization-for-treatment-resistant-depression-in-japan-a-retrospective-claims-database-study
#12
Jörg Mahlich, Sunny Tsukazawa, Frank Wiegand
BACKGROUND: Major depressive disorders (MDDs) including treatment-resistant depression (TRD) are common disabling conditions, but data on their epidemiology in Japan are limited. This study investigated the incidence, epidemiology, and direct medical costs of TRD and pharmaceutically-treated depression (PTD) in Japan to increase our health economic understanding of this phenotype of MDD. METHODS: A retrospective cohort study from a private health insurance claims database estimated the 1-year incidence of PTD and TRD and described the health services used and direct medical costs associated with these conditions...
March 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29119929/mean-diffusivity-in-the-dopaminergic-system-and-neural-differences-related-to-dopaminergic-system
#13
Hikaru Takeuchi, Ryuta Kawashima
The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules. In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29060275/assessing-rtms-effects-in-mdds-cross-modal-comparison-between-resting-state-eeg-and-fmri-connectivity
#14
Yafen Chen, Chuang Li, Guofa Shou, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Han Yuan
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly explored for many neurological and neuropsychiatric conditions. However, the response rate is variable depending on baseline conditions. Optimizing rTMS protocols to improve treatment effects and response rates will depend on reliably assessing brain state conditions. In this regard, neural activity guided optimization has shown potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder called Mal de Debarquement Syndrome (MdDS), a motion perception disorder caused by entrainment to background motion...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29027838/the-role-of-appraisal-in-dysphoric-affect-reactivity-to-positive-laboratory-films-and-daily-life-events-in-depression
#15
Vanessa Panaite, Alana Whittington, Alexandra Cowden Hindash
Hedonic deficits are linked to protracted dysphoric affect (DA) in depression, a disorder characterised by emotion context insensitivity (ECI). Recent findings from daily life studies contradict the ECI view. This study longitudinally investigated DA across laboratory and daily life contexts and the conditions associated with discrepancies in DA reactivity. Thirty-three healthy controls and 41 adults with major depressive disorder (MDD) provided responses to neutral and positive (a) films viewed in the laboratory and (b) daily events recorded over the course of three days using ecological momentary assessment (EMA) methodology...
October 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28967282/resting-state-functional-connectivity-signature-of-treatment-effects-of-repetitive-transcranial-magnetic-stimulation-in-mal-de-debarquement-syndrome
#16
Han Yuan, Guofa Shou, Diamond Gleghorn, Lei Ding, Yoon-Hee Cha
Repetitive transcranial magnetic stimulation (rTMS) has been used in experimental protocols to treat mal de debarquement syndrome (MdDS), a neurological condition that represents a maladaptive brain state resulting from entrainment to external oscillating motion. Medical treatments and biomarkers for MdDS remain limited but neuromodulation with rTMS has shown evidence for therapeutic effects. This study took a neuroimaging approach to examine the neuromodulatory effect of rTMS on MdDS. Twenty individuals with MdDS underwent five daily treatments of rTMS over bilateral dorsolateral prefrontal cortex (DLPFC)...
November 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28752607/reproducibility-of-heart-rate-recovery-in-patients-with-intermittent-claudication
#17
Rafael Yokoyama Fecchio, Marcel Chehuen, Tiago Peçanha, Gabriel Grizzo Cucato, Luiz Augusto Riani Costa, Anthony Scott Leicht, Raphael Mendes Ritti-Dias, Nelson Wolosker, Cláudia Lúcia de Moraes Forjaz
BACKGROUND: Postexercise heart rate recovery (HRR) is a non-invasive tool for cardiac autonomic function assessment. Reproducibility of HRR has been established in healthy subjects; however, no study has evaluated this reproducibility in clinical populations who may present autonomic dysfunction. Patients with peripheral artery disease and intermittent claudication (IC) often present altered cardiac autonomic function and HRR could be an interesting tool for evaluating autonomic responses to interventions in this population...
July 28, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28682878/the-involvement-of-potassium-channel-ork1-in-short-term-memory-and-sleep-in-drosophila
#18
Xiaoyan Zhang, Yabin Zheng, Qingguo Ren, Hong Zhou
BACKGROUND: The sleep and cognitive dysfunction are common in major depressive disorders (MDDs). Recently, the 2-pore domain potassium channel twik-related K(+) channel 1 (TREK-1) has been identified to be closely related to the etiology of MDD. However, whether TREK-1 is involved in the regulation of sleep and cognition is still unknown. METHODS: The present study tried to dissect the role of outwardly rectifying K+ channel-1 (ORK1) (TREK-1 homolog in Drosophila) in sleep and cognition in Drosophila...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28529496/treatment-of-the-mal-de-debarquement-syndrome-a-1-year-follow-up
#19
Mingjia Dai, Bernard Cohen, Catherine Cho, Susan Shin, Sergei B Yakushin
The mal de debarquement syndrome (MdDS) is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS), or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1), and over 330 MdDS patients have now been treated. Here, we report the outcomes of 141 patients (122 females and 19 males) treated 1 year or more ago. We examine the patient's rocking frequency, body drifting, and nystagmus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28424045/a-modified-mediterranean-dietary-intervention-for-adults-with-major-depression-dietary-protocol-and-feasibility-data-from-the-smiles-trial
#20
Rachelle S Opie, Adrienne O'Neil, Felice N Jacka, Josephine Pizzinga, Catherine Itsiopoulos
BACKGROUND: The SMILES trial was the first randomized controlled trial (RCT) explicitly designed to evaluate a dietary intervention, conducted by qualified dietitians, for reducing depressive symptomatology in adults with clinical depression. OBJECTIVES: Here we detail the development of the prescribed diet (modified Mediterranean diet (ModiMedDiet)) for individuals with major depressive disorders (MDDs) that was designed specifically for the SMILES trial. We also present data demonstrating the extent to which this intervention achieved improvements in diet quality...
April 19, 2017: Nutritional Neuroscience
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