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https://www.readbyqxmd.com/read/29119929/mean-diffusivity-in-the-dopaminergic-system-and-neural-differences-related-to-dopaminergic-system
#1
Hikaru Takeuchi, Ryuta Kawashima
The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules. In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29060275/assessing-rtms-effects-in-mdds-cross-modal-comparison-between-resting-state-eeg-and-fmri-connectivity
#2
Yafen Chen, Chuang Li, Guofa Shou, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Han Yuan
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly explored for many neurological and neuropsychiatric conditions. However, the response rate is variable depending on baseline conditions. Optimizing rTMS protocols to improve treatment effects and response rates will depend on reliably assessing brain state conditions. In this regard, neural activity guided optimization has shown potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder called Mal de Debarquement Syndrome (MdDS), a motion perception disorder caused by entrainment to background motion...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29027838/the-role-of-appraisal-in-dysphoric-affect-reactivity-to-positive-laboratory-films-and-daily-life-events-in-depression
#3
Vanessa Panaite, Alana Whittington, Alexandra Cowden Hindash
Hedonic deficits are linked to protracted dysphoric affect (DA) in depression, a disorder characterised by emotion context insensitivity (ECI). Recent findings from daily life studies contradict the ECI view. This study longitudinally investigated DA across laboratory and daily life contexts and the conditions associated with discrepancies in DA reactivity. Thirty-three healthy controls and 41 adults with major depressive disorder (MDD) provided responses to neutral and positive (a) films viewed in the laboratory and (b) daily events recorded over the course of three days using ecological momentary assessment (EMA) methodology...
October 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28967282/resting-state-functional-connectivity-signature-of-treatment-effects-of-repetitive-transcranial-magnetic-stimulation-in-mal-de-debarquement-syndrome
#4
Han Yuan, Guofa Shou, Diamond Gleghorn, Lei Ding, Yoon-Hee Cha
Repetitive transcranial magnetic stimulation (rTMS) has been used in experimental protocols to treat mal de debarquement syndrome (MdDS), a neurological condition that represents a maladaptive brain state resulting from entrainment to external oscillating motion. Medical treatments and biomarkers for MdDS remain limited but neuromodulation with rTMS has shown evidence for therapeutic effects. This study took a neuroimaging approach to examine the neuromodulatory effect of rTMS on MdDS. Twenty individuals with MdDS underwent five daily treatments of rTMS over bilateral dorsolateral prefrontal cortex (DLPFC)...
November 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28752607/reproducibility-of-heart-rate-recovery-in-patients-with-intermittent-claudication
#5
Rafael Yokoyama Fecchio, Marcel Chehuen, Tiago Peçanha, Gabriel Grizzo Cucato, Luiz Augusto Riani Costa, Anthony Scott Leicht, Raphael Mendes Ritti-Dias, Nelson Wolosker, Cláudia Lúcia de Moraes Forjaz
BACKGROUND: Postexercise heart rate recovery (HRR) is a non-invasive tool for cardiac autonomic function assessment. Reproducibility of HRR has been established in healthy subjects; however, no study has evaluated this reproducibility in clinical populations who may present autonomic dysfunction. Patients with peripheral artery disease and intermittent claudication (IC) often present altered cardiac autonomic function and HRR could be an interesting tool for evaluating autonomic responses to interventions in this population...
July 28, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28682878/the-involvement-of-potassium-channel-ork1-in-short-term-memory-and-sleep-in-drosophila
#6
Xiaoyan Zhang, Yabin Zheng, Qingguo Ren, Hong Zhou
BACKGROUND: The sleep and cognitive dysfunction are common in major depressive disorders (MDDs). Recently, the 2-pore domain potassium channel twik-related K(+) channel 1 (TREK-1) has been identified to be closely related to the etiology of MDD. However, whether TREK-1 is involved in the regulation of sleep and cognition is still unknown. METHODS: The present study tried to dissect the role of outwardly rectifying K+ channel-1 (ORK1) (TREK-1 homolog in Drosophila) in sleep and cognition in Drosophila...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28529496/treatment-of-the-mal-de-debarquement-syndrome-a-1-year-follow-up
#7
Mingjia Dai, Bernard Cohen, Catherine Cho, Susan Shin, Sergei B Yakushin
The mal de debarquement syndrome (MdDS) is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS), or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1), and over 330 MdDS patients have now been treated. Here, we report the outcomes of 141 patients (122 females and 19 males) treated 1 year or more ago. We examine the patient's rocking frequency, body drifting, and nystagmus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28424045/a-modified-mediterranean-dietary-intervention-for-adults-with-major-depression-dietary-protocol-and-feasibility-data-from-the-smiles-trial
#8
Rachelle S Opie, Adrienne O'Neil, Felice N Jacka, Josephine Pizzinga, Catherine Itsiopoulos
BACKGROUND: The SMILES trial was the first randomized controlled trial (RCT) explicitly designed to evaluate a dietary intervention, conducted by qualified dietitians, for reducing depressive symptomatology in adults with clinical depression. OBJECTIVES: Here we detail the development of the prescribed diet (modified Mediterranean diet (ModiMedDiet)) for individuals with major depressive disorders (MDDs) that was designed specifically for the SMILES trial. We also present data demonstrating the extent to which this intervention achieved improvements in diet quality...
April 19, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28268279/optimizing-rtms-treatment-of-a-balance-disorder-with-eeg-neural-synchrony-and-functional-connectivity
#9
Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for its potential treatment effects across diverse mental disorders. However, the treatment effect is elusive and the rate of positive responders is not high, which make it in great demand of optimizing rTMS protocols to improve the treatment effects and the rate. In this regard, neural activity guided optimization has indicated great potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226436/optimizing-rtms-treatment-of-a-balance-disorder-with-eeg-neural-synchrony-and-functional-connectivity
#10
Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Han Yuan, Yoon-Hee Cha, Diamond Urbano, Lei Ding, Guofa Shou
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for its potential treatment effects across diverse mental disorders. However, the treatment effect is elusive and the rate of positive responders is not high, which make it in great demand of optimizing rTMS protocols to improve the treatment effects and the rate. In this regard, neural activity guided optimization has indicated great potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28007644/association-between-htr1b-alleles-and-suicidal-ideation-in-individuals-with-major-depressive-disorder
#11
Wei-Tsung Kao, Ming-Chang Yang, For-Wey Lung
Serotonin receptors, also known as 5-hydroxytryptamine receptors (HTRs), play a role in individuals' vulnerability to major depressive disorders (MDDs) and/or suicide attempts. In the first part of the study, we recruited 789 Taiwanese participants, which included 285 MDD patients, 191 MDD patients with a history of suicide attempts (MS), and 313 controls. The three groups were genotyped to identify HTR single nucleotide polymorphisms (SNPs) and we analyzed the correlations among the three groups. In the second part of the study, which involved a functional test of HTR1B allelic and haplotype variants, another 113 MDD patients were recruited...
December 19, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27919003/altered-patterns-of-directed-connectivity-within-the-reading-network-of-dyslexic-children-and-their-relation-to-reading-dysfluency
#12
Gojko Žarić, João M Correia, Gorka Fraga González, Jurgen Tijms, Maurtis W van der Molen, Leo Blomert, Milene Bonte
Reading is a complex cognitive skill subserved by a distributed network of visual and language-related regions. Disruptions of connectivity within this network have been associated with developmental dyslexia but their relation to individual differences in the severity of reading problems remains unclear. Here we investigate whether dysfunctional connectivity scales with the level of reading dysfluency by examining EEG recordings during visual word and false font processing in 9-year-old typically reading children (TR) and two groups of dyslexic children: severely dysfluent (SDD) and moderately dysfluent (MDD) dyslexics...
February 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/27730651/management-of-mal-de-debarquement-syndrome-as-vestibular-migraines
#13
Yaser Ghavami, Yarah M Haidar, Kasra N Ziai, Omid Moshtaghi, Jay Bhatt, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: Mal de debarquement syndrome (MdDS) is a balance disorder that typically starts after an extended exposure to passive motion, such as a boat or plane ride. Management is typically supportive (e.g. physical therapy), and symptoms that persist beyond 6 months have been described as unlikely to remit. This study was conducted to evaluate the response of patients with MdDS to management with migraine prophylaxis, including lifestyle changes and medical therapy. STUDY DESIGN: Prospective review...
July 2017: Laryngoscope
https://www.readbyqxmd.com/read/27660449/the-interactive-effects-of-ketamine-and-magnesium-upon-depressive-like-pathology
#14
Sara Razmjou, Darcy Litteljohn, Chris Rudyk, Shuaib Syed, Melanie Clarke, Rowan Pentz, Zach Dwyer, Shawn Hayley
Approximately one-third of patients with major depressive disorders (MDDs) are resistant to current treatment methods, and the majority of cases relapse at some point during therapy. This has resulted in novel treatments being adopted, including subanesthetic doses of ketamine, which affects aberrant neuroplastic circuits, glutamatergic signaling, and the production of brain-derived neurotrophic factor. Ketamine rapidly relieves depressive symptoms in treatment-resistant major depressive disorder patients with effects that last for up to 2 weeks even after a single administration...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27638086/mal-de-d%C3%A3-barquement-syndrome
#15
REVIEW
T C Hain, M Cherchi
Mal de débarquement syndrome (MdDS) is typified by a prolonged rocking sensation - for a month or longer - that begins immediately following a lengthy exposure to motion. The provoking motion is usually a sea voyage. About 80% of MdDS sufferers are women, and most of them are middle-aged. MdDS patients are troubled by more migraine headaches than controls. Unlike dizziness caused by vestibular disorders or motion sickness, the symptoms of MdDS usually improve with re-exposure to motion. The long duration of symptoms - a month or more - distinguishes MdDS from land-sickness...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27540294/exercise-is-medicine-for-patients-with-major-depressive-disorders-but-only-if-the-pill-is-taken
#16
Markus Gerber, Edith Holsboer-Trachsler, Uwe Pühse, Serge Brand
Major depressive disorders (MDDs) are a widespread and burdensome mental illness associated with a high comorbidity with other conditions and a significantly reduced life expectancy compared to the general population. Therefore, targeted actions are needed to improve physical health in people with MDDs, in addition to ongoing efforts to enhance psychological well-being. Meanwhile, the positive effects of exercise training on the treatment of MDDs are well documented, while compelling evidence exists that exercise interventions can improve cardiorespiratory fitness in clinically meaningful ways...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27484677/optimization-of-routine-monitoring-of-workers-exposed-to-plutonium-aerosols
#17
Estelle Davesne, Benoit Quesne, Antoine De Vita, Eric Chojnacki, Eric Blanchardon, Didier Franck
In case of incidental confinement failure, mixed oxide (MOX) fuel preparation may expose workers to plutonium aerosols. Due to its potential toxicity, occupational exposure to plutonium compounds should be kept as low as reasonably achievable. To ensure the absence of significant intake of radionuclides, workers at risk of internal contamination are monitored by periodic bioassay planned in a routine monitoring programme. From bioassay results, internal dose may be estimated. However, accurate dose calculation relies on known exposure conditions, which are rarely available when the exposure is demonstrated by routine monitoring only...
October 2016: Annals of Occupational Hygiene
https://www.readbyqxmd.com/read/27478503/joint-analysis-of-multiple-high-dimensional-data-types-using-sparse-matrix-approximations-of-rank-1-with-applications-to-ovarian-and-liver-cancer
#18
Gordon Okimoto, Ashkan Zeinalzadeh, Tom Wenska, Michael Loomis, James B Nation, Tiphaine Fabre, Maarit Tiirikainen, Brenda Hernandez, Owen Chan, Linda Wong, Sandi Kwee
BACKGROUND: Technological advances enable the cost-effective acquisition of Multi-Modal Data Sets (MMDS) composed of measurements for multiple, high-dimensional data types obtained from a common set of bio-samples. The joint analysis of the data matrices associated with the different data types of a MMDS should provide a more focused view of the biology underlying complex diseases such as cancer that would not be apparent from the analysis of a single data type alone. As multi-modal data rapidly accumulate in research laboratories and public databases such as The Cancer Genome Atlas (TCGA), the translation of such data into clinically actionable knowledge has been slowed by the lack of computational tools capable of analyzing MMDSs...
2016: BioData Mining
https://www.readbyqxmd.com/read/27428086/cortisol-dhea-ratio-and-hippocampal-volume-a-pilot-study-in-major-depression-and-healthy-controls
#19
Rowen O Jin, Sara Mason, Synthia H Mellon, Elissa S Epel, Victor I Reus, Laura Mahan, Rebecca L Rosser, Christina M Hough, Heather M Burke, Susanne G Mueller, Owen M Wolkowitz
Structural imaging studies investigating the relationship between hippocampal volume (HCV) and peripheral measures of glucocorticoids (GCs) have produced conflicting results in both normal populations and in individuals with MDD, raising the possibility of other modulating factors. In preclinical studies, dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS; together abbreviated, DHEA(S)) have been shown to antagonize the actions of GCs on the central nervous system. Therefore, considering the relationship of HCV to both of these hormones simultaneously may be important, although it has rarely been done in human populations...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27427515/clinical-impact-of-the-interstitial-lung-disease-multidisciplinary-service
#20
Helen E Jo, Ian N Glaspole, Kovi C Levin, Samuel R McCormack, Annabelle M Mahar, Wendy A Cooper, Rhoda Cameron, Samantha J Ellis, Alice M Cottee, Susanne E Webster, Lauren K Troy, Paul J Torzillo, Peter Corte, Karen M Symons, Nicole Taylor, Tamera J Corte
BACKGROUND AND OBJECTIVE: Multidisciplinary discussions (MDDs) have been shown to improve diagnostic accuracy in interstitial lung disease (ILD) diagnosis. However, their clinical impact on patient care has never been clearly demonstrated. We describe the effect that an ILD multidisciplinary service has upon the diagnosis and management of patients with suspected ILD. METHODS: Patients at two specialized centres with suspected ILD underwent ILD multidisciplinary team review (ILD-MDT) (standard ILD clinic visit and diagnostic review at ILD-MDD)...
November 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
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