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Heart failure, diastolic failure, systolic failure

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https://www.readbyqxmd.com/read/29236226/evaluation-of-left-ventricular-diastolic-function-state-of-the-art-after-35%C3%A2-years-with-doppler-assessment
#1
REVIEW
Otto A Smiseth
Left ventricular (LV) diastolic function can be evaluated by echocardiographic indices of LV relaxation/restoring forces, diastolic compliance, and filling pressure. By using a combination of indices, diastolic function can be graded and LV filling pressure estimated with high feasibility and good accuracy. Evaluation of diastolic function is of particular importance in patients with unexplained exertional dyspnea or other symptoms or signs of heart failure which cannot be attributed to impaired LV systolic function and to assess filling pressure in patients with heart failure and reduced LV ejection fraction...
December 13, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/29236195/measures-of-subclinical-cardiac-dysfunction-and-increased-filling-pressures-associate-with-pulmonary-arterial-pressure-in-the-general-population-results-from-the-population-based-rotterdam-study
#2
Ryan J Billar, Maarten J G Leening, Daphne Merkus, Guy G O Brusselle, Albert Hofman, Bruno H Ch Stricker, H Ardeschir Ghofrani, Oscar H Franco, Henning Gall, Janine F Felix
Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available...
December 13, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29230826/evolution-of-biventricular-loading-condition-in-pediatric-lvad-patient-a-prospective-and-observational-study
#3
Arianna Di Molfetta, Roberta Iacobelli, Sergio Filippelli, Giorgia Grutter, Gianluigi Perri, Francesca Iodice, Luciano Pasquini, Paolo Guccione, Antonio Amodeo
The aim of this study was to describe the echocardiographic trend of left ventricular (LV) and right ventricular (RV) function after implantation of a pulsatile flow left ventricular assist device (LVAD) in children. From 2013 to 2016, we prospectively evaluated 13 consecutive pediatric Berlin Heart EXCOR LVAD patients. Clinical and echocardiographic data were collected at baseline, within 24 h after implantation and monthly until LVAD explant. Median age and weight at the implantation was 8 (4-23) months and 5 (4...
December 12, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29228231/novel-echocardiographic-method-to-assess-left-ventricular-chamber-stiffness-and-elevated-end-diastolic-pressure-based-on-time-velocity-integral-measurements-of-pulmonary-venous-and-transmitral-flows
#4
Kazunori Okada, Sanae Kaga, Rika Abiko, Michito Murayama, Takuma Hioka, Masahiro Nakabachi, Shinobu Yokoyama, Hisao Nishino, Ayako Ichikawa, Ayumu Abe, Mutsumi Nishida, Naoya Asakawa, Shingo Tsujinaga, Taichi Hayashi, Hiroyuki Iwano, Satoshi Yamada, Nobuo Masauzi, Taisei Mikami
Aims: The detection of increased left ventricular (LV) chamber stiffness may play an important role in assessing cardiac patients with potential but not overt heart failure. A non-invasive method to estimate it is not established. We investigated whether the echocardiographic backward/forward flow volume ratio from the left atrium (LA) during atrial contraction reflects the LV chamber stiffness. Methods and results: We studied 62 patients who underwent cardiac catheterization and measured their left ventricular end-diastolic pressure (LVEDP) and pressure increase during atrial contraction (ΔPa) from the LV pressure waveform...
December 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29228101/spironolactone-and-resistant-hypertension-in-heart-failure-with-preserved-ejection-fraction
#5
P Rossignol, B Claggett, J Liu, O Vardeny, B Pitt, F Zannad, S Solomon
Background: Recent evidence suggests that the mineralocorticoid receptor antagonist spironolactone should be the preferred fourth line antihypertensive treatment in resistant hypertension (RHTN). Whether spironolactone improves blood pressure (BP) control in heart failure with preserved ejection fraction (HFpEF) and RHTN is unknown. Methods: We identified patients with RHTN, defined as baseline systolic blood pressure (SBP) between 140 and 160 mmHg on 3 or more medications, in the Americas cohort of the TOPCAT trial, in which patients with HFpEF were randomized to spironolactone vs...
December 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29221219/the-paradox-of-the-first-cycle-of-chemotherapy-transient-improvement-of-contractility-and-diastolic-function-after-the-first-cycle-of-anthracycline-based-chemotherapy-a-prospective-clinical-trial
#6
Paweł Stachowiak, Andrzej Wojtarowicz, Marta Milchert-Leszczyńska, Krzysztof Safranow, Michał Falco, Robert Kaliszczak, Zdzisława Kornacewicz-Jach
Aims: Breast cancer is the most common cancer among women, and anthracyclines are the most commonly administered drugs for these patients. Cardiotoxicity is one of the complications, which limits the success of this therapy. Very few studies have evaluated anthracycline toxicities within the first few hours after the first infusion, and the majority of published studies were performed in animal models. The present study aimed to evaluate changes in echocardiographic parameters in women with breast cancer 24 hours after receiving the first dose of an anthracycline...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217757/novel-mitochondria-targeting-peptide-in-heart-failure-treatment-a-randomized-placebo-controlled-trial-of-elamipretide
#7
Melissa A Daubert, Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S Douglas, Christopher O'Connor, Sidney Goldstein, James E Udelson, Hani N Sabbah
BACKGROUND: Mitochondrial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in heart failure management. Elamipretide is a novel tetrapeptide that increases mitochondrial energy; however, its safety, tolerability, and therapeutic effect on cardiac structure and function have not been studied in heart failure with reduced ejection fraction. METHODS AND RESULTS: In this double-blind, placebo-controlled, ascending-dose trial, patients with heart failure with reduced ejection fraction (ejection fraction, ≤35%) were randomized to either a single 4-hour infusion of elamipretide (cohort 1 [n=8], 0...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29216977/noninvasive-cardiac-imaging-and-the-prediction-of-heart-failure-progression-in%C3%A2-preclinical-stage-a-b-subjects
#8
REVIEW
Fei Fei Gong, Duncan J Campbell, David L Prior
Heart failure (HF) continues to grow as a cause of morbidity and mortality in our community and presents a significant public health problem, predominantly in individuals ≥65 years of age. Early intervention in asymptomatic HF subjects (Stage A/B) at risk of progression to symptomatic HF (Stage C/D) may provide an opportunity to halt this epidemic. The ability of cardiac imaging to assess cardiac structure and function permits early identification of those at increased risk of developing symptomatic HF. Systolic, diastolic, and structural left ventricular parameters each predict symptomatic HF, but no single parameter has sufficient sensitivity for screening to identify individuals with Stage A/B HF who are at increased risk of disease progression...
December 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29216285/myocardial-adaption-to-hi-r-t-in-previously-untrained-men-with-a-randomized-longitudinal-cardiac-mr-imaging-study-physical-adaptions-in-untrained-on-strength-and-heart-trial-push-trial
#9
Michael Scharf, Derya Oezdemir, Axel Schmid, Wolfgang Kemmler, Simon von Stengel, Matthias S May, Michael Uder, Michael M Lell
OBJECTIVE: Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance) training (HI(R)T) induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI) study. MATERIALS AND METHODS: 80 untrained middle-aged men were randomly assigned to a HI(R)T-group (n = 40; 43...
2017: PloS One
https://www.readbyqxmd.com/read/29211855/a-rabbit-model-of-progressive-chronic-right-ventricular-pressure-overload
#10
Sara Roldan Ramos, Guido Pieles, Wei Hui, Cameron Slorach, Andrew N Redington, Mark K Friedberg
OBJECTIVES: Right ventricular (RV) failure from increased pressure loading is a frequent consequence of acquired and congenital heart diseases. However, the mechanisms involved in their pathophysiology are still unclear, and few data exist on RV pressure-loading models and early versus late effects on RV and left ventricular responses. We characterized a rabbit model of chronic RV pressure overload and early-late effects on biventricular function. METHODS: Twenty-one New Zealand white rabbits were randomized into 3 groups: (i) sham, (ii) pulmonary artery (PA) banding (PAB) for 3 weeks (PAB3W) and (iii) PAB for 6 weeks (PAB6W)...
December 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29209225/cxl-1020-a-novel-nitroxyl-hno-prodrug-is-more-effective-than-milrinone-in-models-of-diastolic-dysfunction-a-cardiovascular-therapeutic-an-efficacy-and-safety-study-in-the-rat
#11
Steve R Roof, Yukie Ueyama, Reza Mazhari, Robert L Hamlin, J Craig Hartman, Mark T Ziolo, John E Reardon, Carlos L Del Rio
The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. This study investigated the load-independent safety and efficacy of CXL-1020 in two rodent (rat) models of diastolic heart failure and explored potential drug interactions with common HF background therapies. In vivo left-ventricular hemodynamics/pressure-volume relationships assessed before/during a 30 min IV infusion of CXL-1020 demonstrated acute load-independent positive inotropic, lusitropic, and vasodilatory effects in normal rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29206857/z-disc-protein-chapb-induces-cardiomyopathy-and-contractile-dysfunction-in-the-postnatal-heart
#12
Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali
AIMS: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease...
2017: PloS One
https://www.readbyqxmd.com/read/29204655/blood-pressure-trajectories-in-the-20-years-before-death
#13
João Delgado, Kirsty Bowman, Alessandro Ble, Jane Masoli, Yang Han, William Henley, Scott Welsh, George A Kuchel, Luigi Ferrucci, David Melzer
Importance: There is mixed evidence that blood pressure (BP) stabilizes or decreases in later life. It is also unclear whether BP trajectories reflect advancing age, proximity to end of life, or selective survival of persons free from hypertension. Objective: To estimate individual patient BP for each of the 20 years before death and identify potential mechanisms that may explain trajectories. Design, Study, and Participants: We analyzed population-based Clinical Practice Research Datalink primary care and linked hospitalization electronic medical records from the United Kingdom, using retrospective cohort approaches with generalized linear mixed-effects modeling...
December 4, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29203160/myocardial-strain-may-predict-exercise-tolerance-in-patients-with-reduced-and-mid-range-ejection-fraction
#14
Elias Tsougos, George Angelidis, Elias Gialafos, Chara Tzavara, Vaios Tzifos, Ioannis Tsougos, Panagiotis Georgoulias
BACKGROUND: Conventional echocardiographic parameters, such as rest ejection fraction, perform poorly regarding the prediction of exercise tolerance in heart failure. The aim of the present study was to evaluate the contribution of hemodynamic instability in the observed lower functional capacity, investigating the role of left ventricular strain for the prediction of stress test duration in obese hypertensive patients with reduced ejection fraction. METHODS: Sixty-one patients with reduced ejection fraction underwent treadmill exercise echocardiography...
December 1, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29202543/-experts-consensus-on-the-management-of-the-right-heart-function-in-critically-ill-patients
#15
X T Wang, D W Liu, H M Zhang, Y Long, X D Guan, H B Qiu, K J Yu, J Yan, H Zhao, Y Q Tang, X Ding, X C Ma, W Du, Y Kang, B Tang, Y H Ai, H W He, D C Chen, H Chen, W Z Chai, X Zhou, N Cui, H Wang, X Rui, Z J Hu, J G Li, Y Xu, Y Yang, B Ouyan, H Y Lin, Y M Li, X Y Wan, R L Yang, Y Z Qin, Y G Chao, Z Y Xie, R H Sun, Z Y He, D F Wang, Q Q Huang, D P Jiang, X Y Cao, R G Yu, X Wang, X K Chen, J F Wu, L N Zhang, M G Yin, L X Liu, S W Li, Z J Chen, Z Luo
To establish the experts consensus on the right heart function management in critically ill patients. The panel of consensus was composed of 30 experts in critical care medicine who are all members of Critical Hemodynamic Therapy Collaboration Group (CHTC Group). Each statement was assessed based on the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) principle. Then the Delphi method was adopted by 52 experts to reassess all the statements. (1) Right heart function is prone to be affected in critically illness, which will result in a auto-exaggerated vicious cycle...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29194868/narrowing-filtered-qrs-duration-on-signal-averaged-electrocardiogram-predicts-outcomes-in-cardiac-resynchronization-therapy-patients-with-nonischemic-heart-failure
#16
Atsushi Suzuki, Tsuyoshi Shiga, Daigo Yagishita, Yoshimi Yagishita-Tagawa, Kotaro Arai, Yuji Iwanami, Koichiro Ejima, Kyomi Ashihara, Morio Shoda, Nobuhisa Hagiwara
BACKGROUND: To evaluate the impact of changes in the filtered QRS duration (fQRS) on signal-averaged electrocardiograms (SAECGs) from pre- to postimplantation on the clinical outcomes in nonischemic heart failure (HF) patients under cardiac resynchronization therapy (CRT). METHODS: We studied 103 patients with nonischemic HF and sinus rhythm who underwent CRT implantation. SAECGs were obtained within 1 week before and 1 week after implantation and narrowing fQRS was defined as a decrease in fQRS from pre- to postimplantation...
November 30, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29193576/adaptive-servo-ventilation-for-central-sleep-apnoea-in-systolic-heart-failure-results-of-the-major-substudy-of-serve-hf
#17
Martin R Cowie, Holger Woehrle, Karl Wegscheider, Eik Vettorazzi, Susanne Lezius, Wolfgang Koenig, Frank Weidemann, Gillian Smith, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad, Helmut Teschler
AIMS: The SERVE-HF trial investigated the impact of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with systolic heart failure. A preplanned substudy was conducted to provide insight into mechanistic changes underlying the observed effects of ASV, including assessment of changes in left ventricular function, ventricular remodelling, and cardiac, renal and inflammatory biomarkers. METHODS AND RESULTS: In a subset of the 1325 randomised patients, echocardiography, cardiac magnetic resonance imaging (cMRI) and biomarker analysis were performed at baseline, and 3 and 12 months...
November 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29185443/a-feline-hfpef-model-with-pulmonary-hypertension-and-compromised-pulmonary-function
#18
Markus Wallner, Deborah M Eaton, Remus M Berretta, Giulia Borghetti, Jichuan Wu, Sandy T Baker, Eric A Feldsott, Thomas E Sharp, Sadia Mohsin, Mark A Oyama, Dirk von Lewinski, Heiner Post, Marla R Wolfson, Steven R Houser
Heart Failure with preserved Ejection Fraction (HFpEF) represents a major public health problem. The causative mechanisms are multifactorial and there are no effective treatments for HFpEF, partially attributable to the lack of well-established HFpEF animal models. We established a feline HFpEF model induced by slow-progressive pressure overload. Male domestic short hair cats (n = 20), underwent either sham procedures (n = 8) or aortic constriction (n = 12) with a customized pre-shaped band. Pulmonary function, gas exchange, and invasive hemodynamics were measured at 4-months post-banding...
November 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29184539/effects-on-subclinical-heart-failure-in-type-2-diabetic-subjects-on-liraglutide-treatment-vs-glimepiride-both-in-combination-with-metformin-a-randomized-open-parallel-group-study
#19
Thomas Nyström, Irene Padro Santos, Fredric Hedberg, Johan Wardell, Nils Witt, Yang Cao, Leif Bojö, Bo Nilsson, Johan Jendle
Objective: We aimed to investigate the effect of liraglutide treatment on heart function in type 2 diabetes (T2D) patients with subclinical heart failure. Methods: Randomized open parallel-group trial. 62 T2D patients (45 male) with subclinical heart failure were randomized to either once daily liraglutide 1.8 mg, or glimepiride 4 mg, both add on to metformin 1 g twice a day. Mitral annular systolic (s') and early diastolic (e') velocities were measured at rest and during bicycle ergometer exercise, using tissue Doppler echocardiography...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29174250/assessment-of-right-ventriclular-systolic-function-prior-to-cardiac-resynchronization-therapy-does-it-make-any-difference
#20
Mohamed A Abdelhamid, Mazen T Ghanem, Ayman M Abdelmotaleb
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with advanced heart failure (HF). Nearly 30% of candidates are inadequate responders. The benefit of patients with right sided heart failure from CRT is still a matter of debate. We examined the effect of CRT on right ventricular (RV) dimensions and overall systolic function and whether RV function prior to CRT could have an impact on CRT response. METHODS: 94 patients with a mean age of 53...
November 2017: Indian Heart Journal
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