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https://www.readbyqxmd.com/read/29229000/changes-in-specific-substance-involvement-scores-among-sbirt-recipients-in-an-hiv-primary-care-setting
#1
Carol Dawson-Rose, Jessica E Draughon, Yvette Cuca, Roland Zepf, Emily Huang, Bruce A Cooper, Paula J Lum
BACKGROUND: Substance use is common among people living with HIV (PLHIV) and is associated with worse outcomes along the HIV care continuum. One potentially effective clinic-based approach to addressing unhealthy substance use is screening, brief intervention, and referral to treatment (SBIRT). METHODS: We conducted a two-arm randomized trial to examine the effects of a self-administered, computerized SBIRT intervention compared to a clinician-administered SBIRT intervention in an HIV primary clinic...
December 12, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#2
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29209922/altered-brain-morphometry-in-7-year-old-hiv-infected-children-on-early-art
#3
Emmanuel C Nwosu, Frances C Robertson, Martha J Holmes, Mark F Cotton, Els Dobbels, Francesca Little, Barbara Laughton, Andre van der Kouwe, Ernesta M Meintjes
Even with the increased roll out of combination antiretroviral therapy (cART), paediatric HIV infection is associated with neurodevelopmental delays and neurocognitive deficits that may be accompanied by alterations in brain structure. Few neuroimaging studies have been done in children initiating ART before 2 years of age, and even fewer in children within the critical stage of brain development between 5 and 11 years. We hypothesized that early ART would limit HIV-related brain morphometric deficits at age 7...
December 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29174315/workshop-report-nucleic-acid-delivery-devices-for-hiv-vaccines-workshop-proceedings-national-institute-of-allergy-and-infectious-diseases-bethesda-maryland-usa-may-21-2015
#4
Bruce G Weniger, Ian E Anglin, Tina Tong, Michael Pensiero, Jeffrey K Pullen
On May 21st, 2015, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on delivery devices for nucleic acid (NA) as vaccines in order to review the landscape of past and future technologies for administering NA (e.g., DNA, RNA, etc.) as antigen into target tissues of animal models and humans. Its focus was on current and future applications for preventing and treating human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) disease, among other infectious-disease priorities...
November 21, 2017: Vaccine
https://www.readbyqxmd.com/read/29133803/microbial-diversity-of-genital-ulcers-of-hsv-2-seropositive-women
#5
Supriya D Mehta, Ashish K Pradhan, Stefan J Green, Ankur Naqib, Elijah Odoyo-June, Charlotte A Gaydos, Sheila Barry, Alan Landay, Robert C Bailey
We measured the microbial community structure of genital ulcers in women. Swabs from clinically detected ulcers were tested for HSV-2 and Treponema pallidum by polymerase chain reaction (PCR). HSV-2 and T. pallidum were detected by serum antibody testing. Microbial community structure was characterized by high-throughput 16 s rRNA gene amplicon sequencing. Multiple group testing and Elastic net and Lasso regressions identified taxa associated with differences in factors of interest. Among 49 ulcer specimens from 49 HSV-2 seropositive women, by PCR HSV-2 was recovered from 28 (57%) specimens and T...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123514/assessment-of-the-combined-effect-of-epstein-barr-virus-and-plasmodium-falciparum-infections-on-endemic-burkitt-lymphoma-using-a-multiplex-serological-approach
#6
Ruth Aguilar, Delphine Casabonne, Cristina O'Callaghan-Gordo, Marta Vidal, Joseph J Campo, Nora Mutalima, Evelina Angov, Sheetij Dutta, Deepak Gaur, Chetan E Chitnis, Virander Chauhan, Angelika Michel, Silvia de Sanjosé, Tim Waterboer, Manolis Kogevinas, Rob Newton, Carlota Dobaño
Epstein-Barr virus (EBV) is a necessary cause of endemic Burkitt lymphoma (eBL), while the role of Plasmodium falciparum in eBL remains uncertain. This study aimed to generate new hypotheses on the interplay between both infections in the development of eBL by investigating the IgG and IgM profiles against several EBV and P. falciparum antigens. Serum samples collected in a childhood study in Malawi (2005-2006) from 442 HIV-seronegative children (271 eBL cases and 171 controls) between 1.4 and 15 years old were tested by quantitative suspension array technology against a newly developed multiplex panel combining 4 EBV antigens [Z Epstein-Barr replication activator protein (ZEBRA), early antigen-diffuse component (EA-D), EBV nuclear antigen 1, and viral capsid antigen p18 subunit (VCA-p18)] and 15 P...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29117791/implementing-generalized-additive-models-to-estimate-the-expected-value-of-sample-information-in-a-microsimulation-model-results-of-three-case-studies
#7
Dustin J Rabideau, Pamela P Pei, Rochelle P Walensky, Amy Zheng, Robert A Parker
BACKGROUND: The expected value of sample information (EVSI) can help prioritize research but its application is hampered by computational infeasibility, especially for complex models. We investigated an approach by Strong and colleagues to estimate EVSI by applying generalized additive models (GAM) to results generated from a probabilistic sensitivity analysis (PSA). METHODS: For 3 potential HIV prevention and treatment strategies, we estimated life expectancy and lifetime costs using the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) model, a complex patient-level microsimulation model of HIV progression...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29095554/patients-perceptions-of-their-doctors-notes-and-after-visit-summaries-a-mixed-methods-study-of-patients-at-safety-net-clinics
#8
Brittaney M Belyeu, Jared W Klein, Lisa M Reisch, Sue Peacock, Natalia V Oster, Joann G Elmore, Sara L Jackson
BACKGROUND: Patients are increasingly offered electronic access to their doctors' notes, and many consistently receive paper After-Visit Summaries. Specific feedback from patients about notes and summaries are lacking, particularly within safety-net settings. DESIGN: A mixed methods study SETTING AND PARTICIPANTS: Patients with poorly controlled diabetes attending two urban safety-net primary care clinics in Washington State. METHODS: Patients read their own most recent clinic note and After-Visit Summary, then completed a brief survey followed by a focus group discussion (3 groups in a large general medicine teaching clinic and 1 in an HIV/AIDS clinic) about their perceptions of the clinic note and After-Visit Summary...
November 2, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29081993/is-more-research-always-needed-estimating-optimal-sample-sizes-for-trials-of-retention-in-care-interventions-for-hiv-positive-east-africans
#9
Jennifer Uyei, Lingfeng Li, R Scott Braithwaite
INTRODUCTION: Given the serious health consequences of discontinuing antiretroviral therapy, randomised control trials of interventions to improve retention in care may be warranted. As funding for global HIV research is finite, it may be argued that choices about sample size should be tied to maximising health. METHODS: For an East African setting, we calculated expected value of sample information and expected net benefit of sampling to identify the optimal sample size (greatest return on investment) and to quantify net health gains associated with research...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29059424/hiv-care-initiation-a-teachable-moment-for-smoking-cessation
#10
Damon J Vidrine, Summer G Frank, Micah J Savin, Andrew J Waters, Yisheng Li, Sixia Chen, Faith E Fletcher, Roberto C Arduino, Ellen R Gritz
Introduction: Tobacco use among persons living with HIV represents an important risk factor for poor treatment outcomes, morbidity, and mortality. Thus, efforts designed to inform the development of appropriate smoking cessation programs for this population remains a public health priority. To address this need, a study was conducted to longitudinally assess the relationship between intention to quit smoking and cessation over the 12 month period following initiation of HIV care. Methods: Patients initiating HIV care at a large inner city safety net clinic were enrolled (n=378) in a 12-month prospective study...
September 25, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29040209/inherited-and-acquired-clinical-phenotypes-associated-with-neuroendocrine-tumors
#11
Rory E Nicholaides, M Teresa de la Morena
PURPOSE OF REVIEW: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. RECENT FINDINGS: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs) arising in other immunocompromised states...
December 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28986656/sustainability-of-statewide-rapid-hiv-testing-in-labor-and-delivery
#12
Lynn M Yee, Emily S Miller, Anne Statton, Laurie D Ayala, Sarah Deardorff Carter, Ann Borders, Amy E Wong, Yolanda Olszewski, Mardge H Cohen, Patricia M Garcia
The objective was to assess sustainability of a statewide program of HIV rapid testing (RT) for pregnant women presenting for delivery with unknown HIV status. This is a population-based retrospective cohort study of women delivered in Illinois hospitals (2012-15). Deidentified data on RT metrics from state-mandated surveillance reports were compared using descriptive statistics and non-parametric tests of trend. Over 95% of the 608,408 women delivered had documented HIV status at presentation. The rate of undocumented HIV status rose from 4...
October 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28957381/a-group-randomized-trial-using-an-appointment-system-to-improve-adherence-to-art-at-reproductive-and-child-health-clinics-implementing-option-b-in-tanzania
#13
RANDOMIZED CONTROLLED TRIAL
Dennis Ross-Degnan, John Chalker, Jafary Liana, Mwikemo Deborah Kajoka, Richard Valimba, Suleiman Kimatta, Angel Dillip, Catherine Vialle-Valentin, Martha Embrey, Rachel Lieber, Keith Johnson
INTRODUCTION: In October 2013, Tanzania adopted Option B+ under which HIV-positive pregnant women are initiated on antiretroviral therapy in reproductive and child health clinics at diagnosis. Studies have shown that adherence and retention to antiretroviral treatment can be problematic. METHODS: We implemented a group randomized controlled trial in 24 reproductive and child health clinics in eight districts in Mbeya region. The trial tested the impact of implementing paper-based appointment tracking and community outreach systems on the rate of missed appointments and number of days covered by dispensed antiretroviral medications among women previously established on antiretroviral therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28920117/hiv-haart-associated-oxidative-stress-is-detectable-by-metabonomics
#14
REVIEW
Aurelia A Williams, Lungile J Sitole, Debra Meyer
Chronic human immunodeficiency virus (HIV) infection, separately and in combination with highly active antiretroviral therapy (HAART) is closely associated with oxidative stress (OS). Most studies demonstrating redox imbalances in HIV-infected individuals have done so using conventional biochemical methodologies. The limited simultaneous detection of multiple OS markers within one sample is a major drawback of these methodologies and can be addressed through the use of metabonomics. HIV-metabonomic studies utilizing biofluids from HAART cohorts as the investigative source, are on the increase...
October 24, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28900756/systematic-review-of-interventions-for-depression-for-people-living-with-hiv-in-africa
#15
REVIEW
Sarah M Lofgren, Noeline Nakasujja, David R Boulware
Depression interventions for individuals with HIV/AIDS in Africa are being increasingly evaluated. MEDLINE was searched using key terms: depression, Africa, and HIV, to identify depression interventions for HIV-infected adults in Africa. Perinatal women were excluded. Results were extracted and relative change in depression scores for interventions and net effect calculated. The MEDLINE search yielded 18 articles. Six of seven studies evaluating feasibility were positive, and seven of seven studies evaluating acceptability were also positive...
September 12, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28893794/effects-of-hiv-1-tat-and-methamphetamine-on-blood-brain-barrier-integrity-and-function-in-vitro
#16
Sulay Patel, Crystal R Leibrand, Preetha Palasuberniam, Pierre-Olivier Couraud, Babette Weksler, Fay M Jahr, Joseph L McClay, Kurt F Hauser, MaryPeace McRae
Human immunodeficiency (HIV) infection results in neurocognitive deficits in about one half of infected individuals. Despite systemic effectiveness, restricted antiretroviral penetration across the blood-brain barrier (BBB) is a major limitation in fighting CNS-localized infection. Drug abuse exacerbates HIV-induced cognitive and pathologic CNS changes. This study's purpose was to investigate the effects of the HIV-1 protein, Tat, and methamphetamine on factors affecting drug penetration across an in vitro BBB model...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28891715/-where-it-falls-apart-barriers-to-retention-in-hiv-care-in-latino-immigrants-and-migrants
#17
Julie H Levison, Laura M Bogart, Iman F Khan, Dianna Mejia, Hortensia Amaro, Margarita Alegría, Steven Safren
Latino immigrants in the United States are disproportionately affected by HIV. Barriers to consistent attendance (retention) in HIV primary care constrain opportunities for HIV treatment success, but have not been specifically assessed in this population. We conducted semistructured interviews with 37 HIV-infected Latinos (aged ≥18 years and born in Puerto Rico or a Latin American Spanish-speaking country) and 14 HIV providers in metropolitan Boston (total n = 51). The Andersen Model of Healthcare Utilization informed a semistructured interview guide, which bilingual research staff used to explore barriers to HIV care...
September 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28876296/neighborhood-health-care-access-and-sexually-transmitted-infections-among-women-in-the-southern-united-states-a-cross-sectional-multilevel-analysis
#18
Danielle F Haley, Andrew Edmonds, Nadya Belenky, DeMarc A Hickson, Catalina Ramirez, Gina M Wingood, Hector Bolivar, Elizabeth Golub, Adaora A Adimora
INTRODUCTION: The United States has experienced an increase in reportable sexually transmitted infections (STIs) while simultaneously experiencing a decline in safety net services for STI testing and treatment. This multilevel study assessed relationships between neighborhood-level access to health care and STIs among a predominantly Human Immunodeficiency Virus (HIV)-seropositive cohort of women living in the south. METHODS: This cross-sectional multilevel analysis included baseline data from HIV-seropositive and HIV-seronegative women enrolled in the Women's Interagency HIV Study sites in Alabama, Florida, Georgia, Mississippi, and North Carolina between 2013 and 2015 (N = 666)...
August 2, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28799997/epidemiology-of-ischemic-heart-disease-in-hiv
#19
Virginia A Triant, Steven K Grinspoon
PURPOSE OF REVIEW: The purpose of this review is to summarize and synthesize recent data on the risk of ischemic heart disease (IHD) in HIV-infected individuals. RECENT FINDINGS: Recent studies in the field demonstrate an increasing impact of cardiovascular disease (CVD) on morbidity and mortality in HIV relative to AIDS-related diagnoses. Studies continue to support an approximately 1.5 to two-fold increased risk of IHD conferred by HIV, with specific risk varying by sex and virologic/immunologic status...
November 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28777261/orphanhood-and-self-esteem-an-18-year-longitudinal-study-from-an-hiv-affected-area-in-tanzania
#20
Joachim De Weerdt, Kathleen Beegle, Stefan Dercon
BACKGROUND: The HIV epidemic exacerbated the prevalence of prime-aged adult death in many parts of sub-Saharan Africa, resulting in increased rates of orphanhood. Little is known about whether this will coincide with adverse psychosocial well-being in adulthood for those who were orphaned at childhood. METHODS: We studied a cohort of 1108 children from Kagera, a region of Tanzania that was heavily affected by HIV early in the epidemic. During the baseline data collection in 1991-1994, these children were aged 0-16 years and had both parents alive...
November 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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