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https://www.readbyqxmd.com/read/29047198/evaluation-of-narrow-band-ultraviolet-b-phototherapy-in-the-treatment-of-chronic-actinic-dermatitis-in-chinese-patients
#1
Li Ma, Qiaoan Zhang, Yue Hu, Xiaoqun Luo
Few studies have been conducted in chronic actinic dermatitis (CAD) treated with narrowband ultraviolet B (NB UVB) phototherapy, especially in Asian patients. We aim to evaluate the efficacy and safety of NB UVB phototherapy in Chinese patients with CAD. 19 CAD patients of Fitzpatrick skin phototype IV received NB UVB phototherapy in spring and treatments were given 3 times weekly with incremental dose and maintenance therapy was given twice weekly for 3-4 weeks. The mean initial, endpoint, and cumulative dose of NB UVB was 0...
October 19, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29042838/dose-banding-of-intravenous-piperacillin-tazobactam-in-pediatric-surgical-inpatients
#2
Indrajit S Karande, Zoy Goff, Jacqueline Kewley, Shailender Mehta, Thomas Snelling
BACKGROUND: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals. OBJECTIVES: To evaluate whether use of dose-banding for IV piperacillin-tazobactam results in acceptable dose variation from standard practice of individualized prescription of 100 mg/kg in children...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29037848/molecular-mechanism-of-mercury-induced-reproductive-impairments-in-banded-gourami-trichogaster-fasciata
#3
Rajkumar Guchhait, Ankit Chatterjee, Shreyasi Gupta, Manashi Debnath, Dilip Mukherjee, Kousik Pramanick
Mercury is one of the key pollutants responsible for the degradation of natural aquatic ecosystems. Among the different forms of mercury that exist in the environment, mercuric chloride (HgCl2) is the dominant pollutant for freshwater environments as it is used as an ingredient in antiseptics, disinfectants and preservatives, insecticides, batteries and in metallurgical and photographic operations. Pollutant may exert their action on organisms or populations by affecting their normal endocrine function as well as reproduction...
October 14, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29036379/photoluminescence-thermoluminescence-and-optically-stimulated-luminescence-studies-in-zinc-based-fluoropervoskites
#4
Milind Jog, R R Patil, Yogesh More, Munish Kumar, M S Kulkarni, S V Moharil
The optically stimulated luminescence, thermoluminescence and photoluminescence in various Cu and Ag doped zinc based fluoropervoskites are studied. In all the samples, photoluminescence of Cu+ and Ag+ is observed which could be attributed to 3d94 s1←→3d10 and 4d95 s1←→5d10 transitions, respectively. The observed emission is double humped and the main emission band shifts to the lower wavelength side with increasing ionic size of the alkali ion. All the studied fluoropervoskites show reasonable OSL sensitivity...
September 28, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29034394/a-calibrated-uv-led-based-light-source-for-water-purification-and-characterisation-of-photocatalysis
#5
A Sergejevs, C T Clarke, D W E Allsopp, J Marugan, A Jaroenworaluck, W Singhapong, P Manpetch, R Timmers, C Casado, C R Bowen
Photocatalysis has a potential to become a cost effective industrial process for water cleaning. One of the most studied photocatalysts is titanium dioxide which, as a wide band gap semiconductor, requires ultraviolet (UV) light for its photoactivation. This is at the wavelengths where the efficiency of present-day light emitting diodes (LEDs) decreases rapidly, which presents a challenge in the use of UV-LEDs for commercially viable photocatalysis. There is also a need for accurate photocatalysis measurement of remediation rates of water-borne contaminants for determining optimum exposure doses in industrial applications...
October 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29027238/a-deep-convolutional-neural-network-using-directional-wavelets-for-low-dose-x-ray-ct-reconstruction
#6
Eunhee Kang, Junhong Min, Jong Chul Ye
PURPOSE: Due to the potential risk of inducing cancer, radiation exposure by X-ray CT devices should be reduced for routine patient scanning. However, in low-dose X-ray CT, severe artifacts typically occur due to photon starvation, beam hardening, and other causes, all of which decrease the reliability of the diagnosis. Thus, a high-quality reconstruction method from low-dose X-ray CT data has become a major research topic in the CT community. Conventional model-based de-noising approaches are, however, computationally very expensive, and image-domain de-noising approaches cannot readily remove CT-specific noise patterns...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/29024685/cardiac-pathologic-findings-in-three-unusual-cases-of-sudden-cardiac-death-related-to-anorexiant-drugs
#7
Ornella Leone, Valentina Agostini, Alberto Foà, Bruna Cerbelli, Cira Rosaria Tiziana di Gioia, Mariarosaria Aromatario, Costantino Ciallella, Joaquin Lucena, Giulia d'Amati
Amphetamine congeners can be prescribed as anorexiant drugs, despite their potential side effects, including cardiac toxicity. However, the morphologic features of cardiac damage related to protracted use of these compounds are unknown. We provide a detailed description of cardiac autopsy findings in three cases of sudden death associated with protracted use of high-doses of phendimetrazine and/or phenylpropanolamine or bupropion prescribed as anorexiants, in association with other compounds. The main cardiac findings were similar in all three cases: i) mild-moderate hypertrophy of the left ventricle and/or the septum; ii) myocardial non-ischemic scarring (mid-mural and/or sub-epicardial) appearing as discrete foci or with a band/like morphology; iii) mild-moderate intramural small vessel disease, in absence of significant epicardial coronary artery stenosis; iv) acute/recent inflammatory lesions consistent with toxic myocarditis...
October 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/29018123/characterization-of-inner-and-outer-membrane-proteins-from-francisella-tularensis-strains-lvs-and-schu-s4-and-identification-of-potential-subunit-vaccine-candidates
#8
Deborah M B Post, Bram Slütter, Birgit Schilling, Aroon T Chande, Jed A Rasmussen, Bradley D Jones, Alexandria K D'Souza, Lorri M Reinders, John T Harty, Bradford W Gibson, Michael A Apicella
Francisella tularensis is the causative agent of tularemia and a potential bioterrorism agent. In the present study, we isolated, identified, and quantified the proteins present in the membranes of the virulent type A strain, Schu S4, and the attenuated type B strain, LVS (live vaccine strain). Spectral counting of mass spectrometric data showed enrichment for membrane proteins in both strains. Mice vaccinated with whole LVS membranes encapsulated in poly (lactic-co-glycolic acid) (PLGA) nanoparticles containing the adjuvant polyinosinic-polycytidylic acid [poly(I·C)] showed significant protection against a challenge with LVS compared to the results seen with naive mice or mice vaccinated with either membranes or poly(I·C) alone...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28993219/involvement-of-posterior-cingulate-cortex-in-ketamine-induced-psychosis-relevant-behaviors-in-rats
#9
Jingyi Ma, L Stan Leung
The involvement of posterior cingulate cortex (PCC) on ketamine-induced psychosis relevant behaviors was investigated in rats. Bilateral infusion of muscimol, a GABAA receptor agonist, into the PCC significantly antagonized ketamine-induced deficit in prepulse inhibition of a startle reflex (PPI), deficit in gating of hippocampal auditory evoked potentials, and behavioral hyperlocomotion in a dose dependent manner. Local infusion of ketamine directly into the PCC also induced a PPI deficit. Systemic injection of ketamine (3mg/kg,s...
October 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28984755/clinical-and-imaging-features-of-spinal-cord-type-of-neuro-beh%C3%A3-et-disease-a-case-report-and-systematic-review
#10
REVIEW
Hui-Miao Liu, Ci Dong, Yong-Zhi Zhang, Ya-Yun Tian, Hong-Xu Chen, Sai Zhang, Na Li, Ping Gu
RATIONAL: To investigate the clinical and MRI characteristics of spinal cord nerve Behçet's disease. PATIENT CONCERNS: One patient with spinal cord nerve Behçet's disease was admitted to our hospital at October 20, 2015. DIAGNOSE: Spinal cord nerve Behçet's disease. INTERVENTIONS: Retrospective analysis was performed on such case as well as 16 cases of spinal cord nerve Behçet's disease reported in China or abroad...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28973696/neurodevelopment-and-thyroid-hormone-synthesis-inhibition-in-the-rat-quantitative-understanding-within-the-adverse-outcome-pathway-framework
#11
Iman Hassan, Hisham El-Masri, Patricia A Kosian, Jermaine Ford, Sigmund J Degitz, Mary E Gilbert
Adequate levels of thyroid hormones (TH) are needed for proper brain development, deficiencies may lead to adverse neurological outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between developmental exposures and decline in serum TH resulting in neurodevelopmental impairment is poorly understood. The present study developed a quantitative adverse outcome pathway (qAOP) where serum thyroxin (T4) reduction following inhibition of thyroperoxidase in the thyroid gland are described and related to deficits in fetal brain TH and the development of a brain malformation, subcortical band heterotopia...
August 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28957443/a-glycosylated-recombinant-subunit-candidate-vaccine-consisting-of-ehrlichia-ruminantium-major-antigenic-protein1-induces-specific-humoral-and-th1-type-cell-responses-in-sheep
#12
Bonto Faburay, Jodi McGill, Frans Jongejan
Heartwater, or cowdriosis, is a tick-borne disease of domestic and wild ruminants that is endemic in the Caribbean and sub-Saharan Africa. The disease is caused by an intracellular pathogen, Ehrlichia ruminantium and may be fatal within days of the onset of clinical signs with mortality rates of up to 90% in susceptible hosts. Due to the presence of competent tick vectors in North America, there is substantial risk of introduction of heartwater with potentially devastating consequences to the domestic livestock industry...
2017: PloS One
https://www.readbyqxmd.com/read/28955224/cost-utility-analysis-of-lipegfilgrastim-compared-to-pegfilgrastim-for-the-prophylaxis-of-chemotherapy-induced-neutropenia-in-patients-with-stage-ii-iv-breast-cancer
#13
Esse I H Akpo, Irshaad R Jansen, Edith Maes, Steven Simoens
Background: Lipegfilgrastim (Lonquex®) has demonstrated to be non-inferior to pegfilgrastim (Neulasta®) in reducing the duration of severe neutropenia (SN) in patients with stage II-IV breast cancer. Compared to pegfilgrastim, lipegfilgrastim also demonstrated statistically significant lower time to ANC recovery in cycles 1-3, lower incidence of SN in cycle 2 and lower depth of absolute neutrophil count (ANC) nadir in cycles 2 and 3. The aim of this study was to quantify the cost utility of lipegfilgrastim compared to pegfilgrastim in stage II-IV breast cancer patients, taking the perspective of the Belgian payer over a lifetime horizon...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28954811/preclinical-characterization-of-r-3-3s-4s-3-fluoro-4-4-hydroxyphenyl-piperidin-1-yl-1-4-methylbenzyl-pyrrolidin-2-one-bms-986169-a-novel-intravenous-glutamate-n-methyl-d-aspartate-2b-glun2b-receptor-negative-allosteric-modulator-with-potential-in-major-depressive
#14
Linda J Bristow, Jyoti Gulia, Michael R Weed, Bettadapura N Srikumar, Yu-Wen Li, John D Graef, Pattipati S Naidu, Charulatha Sanmathi, Jayant Aher, Tanmaya Bastia, Mahesh Paschapur, Narasimharaju Kalidindi, Kuchibholta Vijaya Kumar, Thaddeus Molski, Rick Pieschl, Alda Fernandes, Jeffrey M Brown, Digavalli V Sivarao, Kimberly Newberry, Mark Bookbinder, Joseph Polino, Deborah Keavy, Amy Newton, Eric Shields, Jean Simmermacher, James Kempson, Jianqing Li, Huiping Zhang, Arvind Mathur, Raja Reddy Kallem, Meenakshee Sinha, Manjunath Ramarao, Reeba K Vikramadithyan, Srinivasan Thangathirupathy, Jayakumar Warrier, Joanne J Bronson, Richard E Olson, John E Macor, Charlie F Albright, Dalton King, Lorin A Thompson, Lawrence R Marcin, Michael Sinz
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), and the phosphate prodrug (BMS-986163), were identified from a drug discovery effort focused on the development of novel, intravenous, glutamate N-methyl-D-aspartate 2B receptor (GluN2B) negative allosteric modulators for treatment resistant depression (TRD). BMS-986169 showed high binding affinity for the GluN2B subunit allosteric modulatory site (Ki = 4.03-6.3 nM) and selectively inhibited GluN2B receptor function in Xenopus oocytes expressing human N-methyl-D-aspartate receptor subtypes (IC50 = 24...
September 27, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28954790/did-the-accuracy-of-oral-amoxicillin-dosing-of-children-improve-after-british-national-formulary-dose-revisions-in-2014-national-cross-sectional-survey-in-england
#15
Olivia Rann, Mike Sharland, Paul Long, Ian C K Wong, Anthony A Laverty, Alex Bottle, Charlotte I Barker, Julia Bielicki, Sonia Saxena
OBJECTIVES: Inaccurate antibiotic dosing can lead to treatment failure, fuel antimicrobial resistance and increase side effects. The British National Formulary for Children (BNFC) guidance recommends oral antibiotic dosing according to age bands as a proxy for weight. Recommended doses of amoxicillin for children were increased in 2014 'after widespread concerns of under dosing'. However, the impact of dose changes on British children of different weights is unknown, particularly given the rising prevalence of childhood obesity in the UK...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28952637/ultraviolet-phototoxicity-of-upconversion-nanoparticles-illuminated-with-near-infrared-light
#16
K E Mironova, D A Khochenkov, A N Generalova, V V Rocheva, N V Sholina, A V Nechaev, V A Semchishen, S M Deyev, A V Zvyagin, E V Khaydukov
Recently introduced upconversion nanoparticles (UCNPs) have pushed the depth of photodynamic therapy (PDT) treatment to the centimetre range by converting deeply-penetrating near-infrared (NIR) radiation to visible radiation for photoexcitation of PDT drugs. Here we demonstrate that the direct exposure of the cancer tissue to phototoxic ultraviolet radiation generated by NIR-photoexcited UCNPs enabled successful PDT. To this aim, core/shell UCNPs of the formula NaYF4:Yb(3+)Tm(3+)/NaYF4 featuring an enhanced band in the ultraviolet UV-A and UV-B spectral bands were rationally designed and synthesised...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28936710/cloning-expression-purification-and-bioactivity-evaluation-of-a-thrombin-like-enzyme-from-deinagkistrodon-acutus-venom-gland-library
#17
An Li, Chuan Zhang, Jie Wang, Junjie Wang, Hailong Jiang, Jianzhong Li, Xingyuan Ma, Wen Zhang, Yiming Lu
OBJECTIVES: To identify a new member of serine proteases from Deinagkistrodon acutus via phage display technique and appraise its biocatalytic activities. RESULTS: A novel thrombin-like enzyme gene was cloned by screening the phage display library of D. acutus venom gland. The gene has a 783 bp ORF encoding 260 amino acids. A recombinant enzyme expression vector was constructed and the fused protein was expressed in Escherichia coli. The protein was purified showing a single band of approx...
September 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28919752/zinc-oxide-nanoparticles-induce-apoptosis-and-autophagy-in-human-ovarian-cancer-cells
#18
Ding-Ping Bai, Xi-Feng Zhang, Guo-Liang Zhang, Yi-Fan Huang, Sangiliyandi Gurunathan
BACKGROUND: Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products such as paint, surface coating, and cosmetics, and recently, they have been explored in biologic and biomedical applications. Therefore, this study was undertaken to investigate the effect of ZnO NPs on cytotoxicity, apoptosis, and autophagy in human ovarian cancer cells (SKOV3). METHODS: ZnO NPs with a crystalline size of 20 nm were characterized with various analytical techniques, including ultraviolet-visible spectroscopy, X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, and atomic force microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28917695/the-impact-of-gabaergic-drugs-on-tms-induced-brain-oscillations-in-human-motor-cortex
#19
Isabella Premoli, Til O Bergmann, Matteo Fecchio, Mario Rosanova, Andrea Biondi, Paolo Belardinelli, Ulf Ziemann
Brain responses to transcranial magnetic stimulation (TMS) as measured with electroencephalography (EEG) have so far been assessed either by TMS-evoked EEG potentials (TEPs), mostly reflecting phase-locked neuronal activity, or time-frequency-representations (TFRs), reflecting oscillatory power arising from a mixture of both evoked (i.e., phase-locked) and induced (i.e., non-phase-locked) responses. Single-pulse TMS of the human primary motor cortex induces a specific pattern of oscillatory changes, characterized by an early (30-200 ms after TMS) synchronization in the α- and β-bands over the stimulated sensorimotor cortex and adjacent lateral frontal cortex, followed by a late (200-400 ms) α- and β-desynchronization over the stimulated and contralateral sensorimotor cortex...
September 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#20
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
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