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Elisa Ferro, Giuseppa Visalli, Maria Angela La Rosa, Basilia Piraino, Rosa Civa, Gaetano Randazzo Papa, Angela Di Pietro
In previously reported studies, we observed significantly high genotoxicity biomarkers in regularly transfused thalassaemic patients, thus, in this study, we better investigated the genotoxic effect of iron overload and of thalassaemia complications, including their drug treatments. The assessment was performed in 64 regularly transfused thalassaemic patients using cytokinesis-block micronucleus and comet assays. All patients were splenectomised and undergoing iron chelation therapy. To reduce hypoxia-induced oxidative damage, the patients with haemoglobin levels <9...
December 8, 2016: Mutagenesis
Banu Torun Acar, Erkan Duman, Saban Simsek
BACKGROUND: To evaluate the clinical outcomes after the implantation of a new trifocal diffractive intraocular lens (IOL) combined with Enhanced depth of focus (EDOF) technology. METHODS: The study enrolled 80 eyes of 40 patients who underwent cataract surgery with bilateral implantation of a diffractive trifocal IOL (Reviol Tri-ED) designed with a combination of enhanced depth of focus. Mean age was 52.09 ± 11.32 years (range from 45 to 70 years). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), corrected intermediate visual acuity (CIVA), uncorrected near visual acuity (UNVA), corrected near visual acuity (CNVA), keratometry (K), and manifest refraction spherical equivalent (MRSE) were evaluated pre- and postoperatively...
November 29, 2016: BMC Ophthalmology
Elisa Ferro, Giuseppa Visalli, Maria Angela La Rosa, Rosa Civa, Gaetano Randazzo Papa, Domenico Giuseppe D'Ascola, Gaetano Roccamo, Basilia Piraino, Carmelo Salpietro, Angela Di Pietro
OBJECTIVES: Redox imbalance and genotoxic damage are commonly observed in β thalassaemic patients. The aim of this study was to assess the role of anaemia in oxidative and genotoxic damage in regularly transfused thalassaemic patients, undergoing iron chelation therapy. METHODS: We studied the relationships of haematological, biochemical and clinical parameters with oxidative (reactive oxygen species and 8-oxo-7,8-dihydro-2'-deoxyguanosine) and genotoxic biomarkers (Comet assay and cytokinesis-block micronucleus test) in blood samples from 105 patients...
November 1, 2016: Hematology (Amsterdam, Netherlands)
Jovan Nikolic, Ahmet Civas, Zoé Lama, Cécile Lagaudrière-Gesbert, Danielle Blondel
Stress granules (SGs) are membrane-less dynamic structures consisting of mRNA and protein aggregates that form rapidly in response to a wide range of environmental cellular stresses and viral infections. They act as storage sites for translationally silenced mRNAs under stress conditions. During viral infection, SG formation results in the modulation of innate antiviral immune responses, and several viruses have the ability to either promote or prevent SG assembly. Here, we show that rabies virus (RABV) induces SG formation in infected cells, as revealed by the detection of SG-marker proteins Ras GTPase-activating protein-binding protein 1 (G3BP1), T-cell intracellular antigen 1 (TIA-1) and poly(A)-binding protein (PABP) in the RNA granules formed during viral infection...
October 2016: PLoS Pathogens
Chris Paget
BACKGROUND: Cytokine modulators (adalimumab, infliximab, etanercept, anakinra, canakinumab, rituximab, tocilizumab and abatacept) are high-cost biologics used primarily in paediatrics to treat patients with juvenile idiopathic arthritis.1 Funding mechanisms are unreliable and inconsistent hence appropriate dose rounding is a key cost-saving measure.2 However, there is a lack of evidence-based guidance for dose rounding in paediatrics.3 AIMS AND OBJECTIVES: Determine if 100% of inpatient cytokine modulator prescriptions in rheumatology are dose rounded up or down to the nearest whole vial, pen or syringe if within 5 or 10% of the dose for patients less or more than 10 kg respectively...
September 2016: Archives of Disease in Childhood
Rudy M M A Nuijts, Soraya M R Jonker, Robert A Kaufer, Ruth Lapid-Gortzak, Javier Mendicute, Cristina Peris Martinez, Stefanie Schmickler, Thomas Kohnen
PURPOSE: To assess the clinical visual outcomes of bilateral implantation of Restor +2.5 diopter (D) multifocal intraocular lenses (IOLs) and contralateral implantation of a Restor +2.5 D multifocal IOL in the dominant eye and Restor +3.0 D multifocal IOL in the fellow eye. SETTING: Multicenter study at 8 investigative sites. DESIGN: Prospective randomized parallel-group patient-masked 2-arm study. METHODS: This study comprised adults requiring bilateral cataract extraction followed by multifocal IOL implantation...
February 2016: Journal of Cataract and Refractive Surgery
Laurynas Čivas, Vytautas Kesminas, S Mažeika P Sullivan
Further resolving physicochemical-fish associations would be of considerable benefit to advancing both scientific research and monitoring programs in the Baltic states. We collected 3 years of coordinated hydrogeomorphic, water-chemistry, and fish assemblage data at 11 study reaches along the Nevėžis River of central Lithuania and assessed their relative influence on fish assemblages. Of the 23 fish species surveyed in the Nevėžis River, omnivorous and tolerant species were most common. Both water chemistry and physical, hydrogeomorphic characteristics emerged as predictors of fish assemblage descriptors...
February 2016: Environmental Monitoring and Assessment
Hiroaki Kawano, Naohiro Ohshita, Kimiko Katome, Takako Kadota, Michiko Kinoshita, Yayoi Matsuoka, Yasuo M Tsutsumi, Shinji Kawahito, Katsuya Tanaka, Shuzo Oshita
BACKGROUND: We investigated the effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery. METHODS: Patients were randomly divided into three groups: those maintained with sevoflurane (Group S, n=42), propofol (Group P, n=42), or combined propofol and sevoflurane (Group PS, n=42). We assessed complete response (no postoperative nausea and vomiting and no rescue antiemetic use), incidence of nausea and vomiting, nausea severity score, vomiting frequency, rescue antiemetic use, and postoperative pain at 2 and 24h after surgery...
January 2016: Brazilian Journal of Anesthesiology
Muhittin Karaman, Murat Budakoglu, Damla Uca Avci, Emre Ozelkan, Ali Bulbul, Melda Civas, Suat Tasdelen
The changes in wetlands that occur through natural processes, as well as through industrialization and agricultural activities, are decreasing and even annihilating the living spaces of endemic species. Acigöl (Denizli, Turkey), which is a suitable habitat for flamingos (Phoenicopterus ruber), is a lake that is affected by seasonal anomalies as a result of being shallow. Acigöl, which is fed by precipitation, groundwater and the springs that occur along tectonic faults, has no water output other than evaporation and industrial activities...
January 2015: Journal of Environmental Biology
J D Hecq, M Godet, J Jamart, B Bihin, L Galanti
BACKGROUND: Other injectable preparations than parenteral nutrition admixture and injectable cytotoxic drugs could be prepared by Centralised IntraVenous Admixture Service (CIVAS) if the Long-term stability of the drugs is known. However, this information is not always available. PURPOSE: To develop a program of chemical drug stability analysis in collaboration between Hospital Pharmacy, Medical Laboratory and Scientific Support Unit to determine the long-term stability of largely used injectable anti-infectious and non-anti-infectious drugs...
September 2015: Journal de Pharmacie de Belgique
C Czoski Murray, M Twiddy, D Meads, S Hess, J Wright, E D Mitchell, C Hulme, S Dodd, H Gent, A Gregson, K McLintock, D K Raynor, K Reynard, P Stanley, R Vincent, J Minton
INTRODUCTION: Outpatient parenteral antimicrobial therapy (OPAT) is used to treat a wide range of infections, and is common practice in countries such as the USA and Australia. In the UK, national guidelines (standards of care) for OPAT services have been developed to act as a benchmark for clinical monitoring and quality. However, the availability of OPAT services in the UK is still patchy and until quite recently was available only in specialist centres. Over time, National Health Service (NHS) Trusts have developed OPAT services in response to local needs, which has resulted in different service configurations and models of care...
August 21, 2015: BMJ Open
J-P Bibring, Y Langevin, J Carter, P Eng, B Gondet, L Jorda, S Le Mouélic, S Mottola, C Pilorget, F Poulet, M Vincendon
The structure and composition of cometary constituents, down to their microscopic scale, are critical witnesses of the processes and ingredients that drove the formation and evolution of planetary bodies toward their present diversity. On board Rosetta's lander Philae, the Comet Infrared and Visible Analyser (CIVA) experiment took a series of images to characterize the surface materials surrounding the lander on comet 67P/Churyumov-Gerasimenko. Images were collected twice: just after touchdown, and after Philae finally came to rest, where it acquired a full panorama...
July 31, 2015: Science
J-D Hecq, M Godet, J Jamart, L Galanti
OBJECTIVE: Microwave freeze-thaw treatment (MFTT) of injectable drugs can support the development of centralized intravenous admixtures services (CIVAS). The aim of the review is to collect information and results about this method. METHODS: A systematic review of the scientific literature about injectable drug stability studies was performed. The data are presented in a table and describe name of the drug, producer, final concentration, temperature and time of freezing storage, type of microwave oven, thawing power, method of dosage and results after treatment or final long-term storage at 5±3 °C...
November 2015: Annales Pharmaceutiques Françaises
Nabil D Sulaiman, Hossam Hamdy
BACKGROUND: This paper describes an assessment approach of clinical competencies which widens the number of problems and tasks evaluated using videos and images. METHOD: Clinical Image and Video Assessment (CIVA) was used to assess clinical reasoning and decision making of final year medical students. Forty to fifty clinical videos and images supported by rich text vignette and reviewed by subject matter experts were selected based on examination blueprints for analysis...
2013: BMC Medical Education
Elisa Ferro, Giuseppa Visalli, Rosa Civa, Maria Angela La Rosa, Gaetano Randazzo Papa, Barbara Baluce, Domenico Giuseppe D'Ascola, Basilia Piraino, Carmelo Salpietro, Angela Di Pietro
Chronic anemia and tissue hypoxia increase intestinal iron absorption and mitochondrial impairment in thalassemic patients. Regular blood transfusions improve hemoglobin levels but determine an iron overload that induces reactive oxygen species (ROS) overproduction. The aim of this study was to assess cellular oxidative damage by detection of ROS, lipid peroxidation, 8-oxo-dG, and mitochondrial transmembrane potential (Δψ(m)) in transfused and untransfused thalassemic patients. We have also evaluated genotoxicity by CBMN and comet assay...
November 15, 2012: Free Radical Biology & Medicine
Stéphanie Berthouzoz, Lina Berger, Pascal Bonnabry, André Pannatier
Injectable drugs are high-risk products and their reconstitution in hospital wards is a potential source of errors. Thus, in order to secure the reconstitution process and thereby improve safety, the pharmacy department of Lausanne University Hospital is focusing on developing ready-to-use forms (CIVAS). These preparations are compounded in controlled clean rooms and are analyzed prior to release. In the intensive care unit, amiodarone 12.5 mg/mL in glucose 5% is one of the high-risk preparations, which has led the pharmacy to develop a ready-to-use solution...
2012: Chimia
J-D Hecq, J Jamart, L Galanti
INTRODUCTION: Microwave freeze-thaw treatment (MFTT) of injectable drugs can support the development of centralized intravenous admixtures services (CIVAS). The aim of this review is to collect information about the stability of cytotoxic and hazardous drugs after this treatment. METHODS: The scientific literature about drug stability studies was reviewed. The data describe the name of the drug, the manufacturer, the final concentration, the temperature and time of freezing storage, type of microwave oven, the thawing power, the measurement, the method and the results after treatment and final long-term storage at 5±3°C...
July 2012: Annales Pharmaceutiques Françaises
Pierre Génin, Rongtuan Lin, John Hiscott, Ahmet Civas
BACKGROUND: Induction of Type I Interferon (IFN) genes constitutes an essential step leading to innate immune responses during virus infection. Sendai virus (SeV) infection of B lymphoid Namalwa cells transiently induces the transcriptional expression of multiple IFN-A genes. Although transcriptional activation of IFN-A genes has been extensively studied, the mechanism responsible for the attenuation of their expression remains to be determined. PRINCIPAL FINDINGS: In this study, we demonstrate that virus infection of Namalwa cells induces transient recruitment of HDAC3 (histone deacetylase 3) to IFN-A promoters...
2012: PloS One
Sharon M Civa
No abstract text is available yet for this article.
September 2011: Caring: National Association for Home Care Magazine
Yuya Koike, Kenji Takizawa, Yukihisa Ogawa, Atsuko Fujikawa, Misako Yoshimatsu, Yasuo Nakajima
PURPOSE: To evaluate the efficacy of cement injection under vacuum aspiration (CIVAS) of cleft contents in percutaneous vertebroplasty for osteoporotic vertebral compression fractures with an intravertebral cleft. MATERIALS AND METHODS: From April 2008 to October 2010, vertebroplasty for single-level osteoporotic vertebral compression fractures with clefts was performed in 34 patients (seven women, 27 men; mean age, 77 y) with CIVAS and in 41 patients (three women, 38 men; mean age, 77 y) by conventional injection (control group)...
December 2011: Journal of Vascular and Interventional Radiology: JVIR
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