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https://www.readbyqxmd.com/read/28821391/clinical-decision-support-to-effeciently-identify-patients-eligible-for-advanced-heart-failure-therapies
#1
R Scott Evans, Abdallah G Kfoury, Benjamin D Horne, James F Lloyd, Jose Benuzillo, Kismet D Rasmusson, Colleen Roberts, Donald L Lappé
BACKGROUND: Patients who need and receive timely advanced heart failure (HF) therapies have better long-term survival. However, many of these patients are not identified and referred as soon as possible. METHODS: A clinical decision support (CDS) application sent secure email notifications to HF patients' providers when they transitioned to advanced disease. Patients identified with CDS in 2015 were compared to control patients from 2013-14. Kaplan-Meier methods and Cox regression were used in this intention-to-treat analysis to compare differences between visits to specialized heart facilities and survival...
August 15, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28815879/calibrated-imaging-reveals-altered-grey-matter-metabolism-related-to-white-matter-microstructure-and-symptom-severity-in-multiple-sclerosis
#2
Nicholas A Hubbard, Monroe P Turner, Minhui Ouyang, Lyndahl Himes, Binu P Thomas, Joanna L Hutchison, Shawheen Faghihahmadabadi, Scott L Davis, Jeremy F Strain, Jeffrey Spence, Daniel C Krawczyk, Hao Huang, Hanzhang Lu, John Hart, Teresa C Frohman, Elliot M Frohman, Darin T Okuda, Bart Rypma
Multiple sclerosis (MS) involves damage to white matter microstructures. This damage has been related to grey matter function as measured by standard, physiologically-nonspecific neuroimaging indices (i.e., blood-oxygen-level dependent signal [BOLD]). Here, we used calibrated functional magnetic resonance imaging and diffusion tensor imaging to examine the extent to which specific, evoked grey matter physiological processes were associated with white matter diffusion in MS. Evoked changes in BOLD, cerebral blood flow (CBF), and oxygen metabolism (CMRO2 ) were measured in visual cortex...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28800894/examining-unanswered-questions-about-the-home-environment-and-childhood-obesity-disparities-using-an-incremental-mixed-methods-longitudinal-study-design-the-family-matters-study
#3
Jerica M Berge, Amanda Trofholz, Allan Tate, Maureen Beebe, Angela Fertig, Michael Miner, Scott Crow, Kathleen A Culhane-Pera, Shannon Pergament, Dianne Neumark-Sztainer
There are disparities in the prevalence of childhood obesity for children from low-income and minority households. Mixed-methods studies that examine home environments in an in-depth manner are needed to identify potential mechanisms driving childhood obesity disparities that have not been examined in prior research. The Family Matters study aims to identify risk and protective factors for childhood obesity in low-income and minority households through a two-phased incremental, mixed-methods, and longitudinal approach...
August 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28798746/automated-analysis-of-flow-cytometry-data-to-reduce-inter-lab-variation-in-the-detection-of-major-histocompatibility-complex-multimer-binding-t-cells
#4
Natasja Wulff Pedersen, P Anoop Chandran, Yu Qian, Jonathan Rebhahn, Nadia Viborg Petersen, Mathilde Dalsgaard Hoff, Scott White, Alexandra J Lee, Rick Stanton, Charlotte Halgreen, Kivin Jakobsen, Tim Mosmann, Cécile Gouttefangeas, Cliburn Chan, Richard H Scheuermann, Sine Reker Hadrup
Manual analysis of flow cytometry data and subjective gate-border decisions taken by individuals continue to be a source of variation in the assessment of antigen-specific T cells when comparing data across laboratories, and also over time in individual labs. Therefore, strategies to provide automated analysis of major histocompatibility complex (MHC) multimer-binding T cells represent an attractive solution to decrease subjectivity and technical variation. The challenge of using an automated analysis approach is that MHC multimer-binding T cell populations are often rare and therefore difficult to detect...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28796444/the-michigan-risk-score-to-predict-peripherally-inserted-central-catheter-associated-thrombosis
#5
Vineet Chopra, Scott Kaatz, Anna Conlon, David Paje, Paul J Grant, Mary A M Rogers, Steven J Bernstein, Sanjay Saint, Scott A Flanders
BACKGROUND: Peripherally inserted central catheters (PICCs) are associated with upper extremity deep vein thrombosis (DVT). We developed a score to predict risk of PICC-related thrombosis. METHODS: Using data from the Michigan Hospital Medicine Safety consortium, image-confirmed upper-extremity DVT cases were identified. A logistic, mixed effects model with hospital-specific random intercepts was used to identify factors associated with PICC-DVT. Points were assigned to each predictor, stratifying patients into four classes of risk...
August 10, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28783808/recrudescence-of-deficits-after-stroke-clinical-and-imaging-phenotype-triggers-and-risk-factors
#6
Mehmet A Topcuoglu, Esen Saka, Scott B Silverman, Lee H Schwamm, Aneesh B Singhal
Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon. Objective: To investigate the clinical features, triggers, and risk factors for PSR. Design, Setting, and Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. The study used the Massachusetts General Hospital Research Patient Data Repository to identify patients for the period January 1, 2000, to November 30, 2015, who had a primary or secondary diagnosis of cerebrovascular disease, who underwent magnetic resonance imaging of the brain at least once, and whose inpatient or outpatient clinician note or discharge summary stated the term recrudescence...
August 7, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28774790/recovery-and-assessment-of-leukocytes-from-lr-express-filters
#7
Abby K Wegehaupt, Ellen K Roufs, Cory R Hewitt, Marisela L Killian, Oxana Gorbatenko, Cynthia M Anderson, M Scott Killian
Leukocytes, or white blood cells, are used for a variety of investigational purposes and they offer advantages over laboratory-adapted cell lines. Leukocytes that are typically discarded by blood banks during the collection of red blood cells, platelets, and plasma can often be obtained for research use. However, the available leukocytes are frequently contained within a blood filtration device, such as the Terumo LR Express (TLRE) filter. In this study, procedures were evaluated for the ability to elute viable leukocytes from TLRE filters...
July 31, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28766127/metabolic-profiling-of-gestational-diabetes-in-obese-women-during-pregnancy
#8
Sara L White, Dharmintra Pasupathy, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Annette L Briley, Paul T Seed, Paul Welsh, Lucilla Poston
AIMS/HYPOTHESIS: Antenatal obesity and associated gestational diabetes (GDM) are increasing worldwide. While pre-existing insulin resistance is implicated in GDM in obese women, the responsible metabolic pathways remain poorly described. Our aim was to compare metabolic profiles in blood of obese pregnant women with and without GDM 10 weeks prior to and at the time of diagnosis by OGTT. METHODS: We investigated 646 women, of whom 198 developed GDM, in this prospective cohort study, a secondary analysis of UK Pregnancies Better Eating and Activity Trial (UPBEAT), a multicentre randomised controlled trial of a complex lifestyle intervention in obese pregnant women...
August 1, 2017: Diabetologia
https://www.readbyqxmd.com/read/28765264/anti-inflammatory-effects-of-exercise-training-in-adipose-tissue-do-not-require-fgf21
#9
Jay Wayne Porter, Joe Lee Rowles, Justin A Fletcher, Terese M Zidon, Nathan C Winn, Leighton T McCabe, Young-Min Park, James W Perfield, John P Thyfault, R Scott Rector, Jaume Padilla, Victoria Vieira-Potter
Exercise enhances insulin sensitivity; it also improves adipocyte metabolism and reduces adipose tissue inflammation through poorly-defined mechanisms. Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone-like protein whose insulin-sensitizing properties are predominantly mediated via receptor signaling in adipose tissue (AT). Recently, FGF21 has also been demonstrated to have anti-inflammatory properties. Meanwhile, an association between exercise and increased circulating FGF21 levels has been reported in some, but not all studies...
August 1, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28760886/intrinsic-disorder-in-the-partitioning-protein-korb-persists-after-cooperative-complex-formation-with-operator-dna-and-kora
#10
Eva I Hyde, Phillip Callow, Karthik Rajasekar, Peter Timmins, Trushar Patel, Giuliano Siligardi, Rohanah Hussain, Scott White, Christopher M Thomas, David J Scott
The ParB protein, KorB, from the RK2 plasmid is required for DNA partitioning and transcriptional repression. It acts co-operatively with other proteins, including the repressor KorA. Like many multifunctional proteins, KorB contains regions of intrinsically disordered structure, existing in a large ensemble of interconverting conformations. Using NMR spectroscopy, circular dichroism, and small angle neutron scattering, we have studied KorB selectively within its binary complexes with KorA and DNA, and within the ternary KorA/KorB/DNA complex...
July 31, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28747255/adjuvant-gemcitabine-docetaxel-chemotherapy-for-stage-i-uterine-leiomyosarcoma-trends-and-survival-outcomes
#11
Ramey D Littell, Lue-Yen Tucker, Tina Raine-Bennett, Ted E Palen, Eve Zaritsky, Romain Neugebauer, Julia Embry-Schubert, Scott E Lentz
OBJECTIVE: To assess recent trends of administering adjuvant gemcitabine-docetaxel (GD) chemotherapy for Stage I uterine leiomyosarcoma, and to compare disease-free and overall survival between women who received and did not receive adjuvant GD chemotherapy. METHODS: All patients diagnosed with Stage I uterine leiomyosarcoma in a California-Colorado population-based health plan inclusive of 2006-2013 were included in a retrospective cohort. Adjuvant GD chemotherapy rates, clinico-pathologic characteristics and survival estimates were assessed...
July 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28743195/examining-the-relationship-between-post-traumatic-stress-disorder-and-social-participation-among-veterans-with-spinal-cord-injuries-and-disorders
#12
Bella Etingen, Sara M Locatelli, Scott Miskevics, Sherri L LaVela
PURPOSE: The objectives of this study were to examine differences in social participation among Veterans with spinal cord injuries/disorders with and without post-traumatic stress disorder, and determine if lower social participation was independently associated with having post-traumatic stress disorder. METHODS: A cross-sectional mailed national survey was sent to a national sample of Veterans with spinal cord injuries/disorders who received prior-year Veterans Affairs healthcare...
July 26, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28737649/race-age-and-geography-impact-hepatitis-c-genotype-distribution-in-the-united-states
#13
Stuart C Gordon, Sheri Trudeau, Jia Li, Yueren Zhou, Loralee B Rupp, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Mei Lu
GOALS: To determine the impact of geography and patient characteristics on hepatitis C virus (HCV) genotype and subtype distribution in a large sample of patients under routine clinical care BACKGROUND:: HCV genotype impacts disease course and response to treatment. Although several studies have reported genotype distribution within specific US populations, there are no comprehensive descriptions in large, geographically diverse cohorts. STUDY: Using data from the Chronic Hepatitis Cohort Study, we present the distribution of HCV genotypes (GT) and subtypes (ST) among a racially diverse cohort of over 8000 HCV-infected patients from four large US health systems...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28735037/injection-drug-use-and-overdose-among-young-adults-who-use-prescription-opioids-non-medically
#14
Elliott J Liebling, Traci C Green, Scott E Hadland, Brandon D L Marshall
INTRODUCTION: Non-medical prescription opioid (NMPO) use is a critical public health problem in the United States, with 2.1 million new initiates annually. Young adult NMPO users are at high risk for initiating injection drug use. We assessed correlates of injection drug use among young adult NMPO users in Rhode Island, a state heavily impacted by opioid overdose. METHODS: We used data from the Rhode Island Young Adult Prescription Drug Study (RAPiDS), which recruited 199 residents aged 18-29 who reported past-30-day NMPO use (65...
July 18, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28733645/hdac3-is-a-molecular-brake-of-the-metabolic-switch-supporting-white-adipose-tissue-browning
#15
Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W Hiebert, Maurizio Crestani
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellular energy metabolism, but their role in white adipose tissue physiology remains incompletely understood. Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and function. Selective ablation of Hdac3 in fat switches the metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and β-oxidation that potentiates WAT oxidative capacity and ultimately supports browning...
July 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28729889/differential-methylation-at-mhc-in-cd4-t-cells-is-associated-with-multiple-sclerosis-independently-of-hla-drb1
#16
Vicki E Maltby, Rodney A Lea, Katherine A Sanders, Nicole White, Miles C Benton, Rodney J Scott, Jeannette Lechner-Scott
BACKGROUND: Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA methylation is an epigenetic mechanism that can influence gene expression and has the potential to mediate the effects of environmental factors on MS. In a previous study, we found a differentially methylation region (DMR) at MHC HLA-DRB1 that was associated within relapsing-remitting MS (RRMS) patients in CD4(+) T cells...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28727540/community-based-preclinical-patient-navigation-for-colorectal-cancer-screening-among-older-black-men-recruited-from-barbershops-the-mister-b-trial
#17
Helen Cole, Hayley S Thompson, Marilyn White, Ruth Browne, Chau Trinh-Shevrin, Scott Braithwaite, Kevin Fiscella, Carla Boutin-Foster, Joseph Ravenell
OBJECTIVES: To test the effectiveness of a preclinical, telephone-based patient navigation intervention to encourage colorectal cancer (CRC) screening among older Black men. METHODS: We conducted a 3-parallel-arm, randomized trial among 731 self-identified Black men recruited at barbershops between 2010 and 2013 in New York City. Participants had to be aged 50 years or older, not be up-to-date on CRC screening, have uncontrolled high blood pressure, and have a working telephone...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28724735/dual-function-of-the-pectoral-girdle-for-feeding-and-locomotion-in-white-spotted-bamboo-sharks
#18
Ariel L Camp, Bradley Scott, Elizabeth L Brainerd, Cheryl D Wilga
Positioned at the intersection of the head, body and forelimb, the pectoral girdle has the potential to function in both feeding and locomotor behaviours-although the latter has been studied far more. In ray-finned fishes, the pectoral girdle attaches directly to the skull and is retracted during suction feeding, enabling the ventral body muscles to power rapid mouth expansion. However, in sharks, the pectoral girdle is displaced caudally and entirely separate from the skull (as in tetrapods), raising the question of whether it is mobile during suction feeding and contributing to suction expansion...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28722628/serologic-evidence-of-various-arboviruses-detected-in-white-tailed-deer-odocoileus-virginianus-in-the-united-states
#19
Kerri Pedersen, Eryu Wang, Scott C Weaver, Paul C Wolf, Adam R Randall, Kyle R Van Why, Amelia P A Travassos Da Rosa, Thomas Gidlewski
White-tailed deer (Odocoileus virginianus) are an abundant mammal with a wide geographic distribution in the United States, which make them good sentinels for monitoring arboviral activity across the country. Exposure to various arboviruses has been detected in white-tailed deer, typically in conjunction with another diagnostic finding. To better assess the exposure of white-tailed deer to seven arboviruses, we tested 1,508 sera collected from 2010 to 2016 for antibodies to eastern equine encephalitis (2.5%), Powassan (4...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721200/protein-bound-polyphenols-create-ghost-band-artifacts-during-chemiluminescence-based-antigen-detection
#20
Nathalie Plundrich, Mary Ann Lila, Edward Foegeding, Scott Laster
Antigen detection during Western blotting commonly utilizes a horseradish peroxidase-coupled secondary antibody and enhanced chemiluminescent substrate. We utilized this technique to examine the impact of green tea-derived polyphenols on the binding of egg white protein-specific IgE antibodies from allergic human plasma to their cognate antigens. Our experiments unexpectedly showed that green tea-derived polyphenols, when stably complexed with egg white proteins, caused hyperactivation of horseradish peroxidase resulting in the appearance of white "ghost" bands...
2017: F1000Research
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