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https://www.readbyqxmd.com/read/29036474/casanova-a-multiclass-support-vector-machine-model-for-the-classification-of-human-sperm-motility-patterns
#1
Summer G Goodson, Sarah White, Alicia M Stevans, Sanjana Bhat, Chia-Yu Kao, Scott Jaworski, Tamara R Marlowe, Martin Kohlmeier, Leonard McMillan, Steven H Zeisel, Deborah A O'Brien
The ability to accurately monitor alterations in sperm motility is paramount to understanding multiple genetic and biochemical perturbations impacting normal fertilization. Computer-aided sperm analysis (CASA) of human sperm typically reports motile percentage and kinematic parameters at the population level, and uses kinematic gating methods to identify subpopulations such as progressive or hyperactivated sperm. The goal of this study was to develop an automated method that classifies all patterns of human sperm motility during in vitro capacitation following the removal of seminal plasma...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29029210/lesinurad-monotherapy-in-gout-patients-intolerant-to-a-xanthine-oxidase-inhibitor-a-6-month-phase-3-clinical-trial-and-extension-study
#2
Anne-Kathrin Tausche, Rieke Alten, Nicola Dalbeth, Jeff Kopicko, Maple Fung, Scott Adler, Nihar Bhakta, Chris Storgard, Scott Baumgartner, Kenneth Saag
Objective: To investigate the efficacy and safety of lesinurad, a selective uric acid reabsorption inhibitor, in a 6 month, phase 3 clinical trial and extension study. Methods: Patients with gout who cannot take a xanthine oxidase inhibitor (XOI) and have serum uric acid (sUA) ⩾6.5 mg/dl were randomized to receive oral lesinurad (400 mg daily) or placebo. The primary endpoint was the proportion of patients with sUA <6.0 mg/dl at month 6. Safety assessments included treatment-emergent adverse events (TEAEs) and laboratory data...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/29021776/sex-differences-in-rt-pa-utilization-at-hospitals-treating-stroke-the-national-inpatient-sample
#3
Amelia K Boehme, Brendan G Carr, Scott Eric Kasner, Karen C Albright, Michael J Kallan, Mitchell S V Elkind, Charles C Branas, Michael T Mullen
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US. METHODS: Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs. RESULTS: There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29016948/tertiary-care-clinical-experience-with-intravenous-lidocaine-infusions-for-the-treatment-of-chronic-pain
#4
Eli Iacob, Emily E Hagn, Jill Sindt, Shane Brogan, Scott C Tadler, Konrad S Kennington, Bradford D Hare, Christina E Bokat, Gary W Donaldson, Akiko Okifuji, Scott R Junkins
Objective: To evaluate the safety of and long-term pain relief due to intravenous lidocaine infusion for the treatment of chronic pain in a tertiary pain management clinic. Design: Retrospective chart review. Methods: Medical records were reviewed from 233 adult chronic pain patients who underwent one to three lidocaine infusions. The initial lidocaine challenge consisted of 1,000 mg/h administered intravenously for up to 30 minutes until infusion was complete, full pain resolution, the patient requested to stop, side effects (SEs) became intolerable, and/or if there were any safety concerns...
July 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28988793/the-combined-roles-of-nonsomatic-depressive-symptomatology-neurocognitive-function-and-current-substance-use-in-medication-adherence-in-adults-living-with-hiv-infection
#5
Travis M Scott, Desiree Byrd, Miguel Arce Rentería, Kelly Coulehan, Caitlin Miranda, Armando Fuentes, Monica Rivera Mindt
Depression, global neurocognitive (GNC) function, and substance use disorders (SUDs) are each associated with medication adherence in persons living with HIV (PLWH). Because somatic symptoms can inflate depression scores in PLWH, the role of nonsomatic depressive symptomatology (NSDS) should be considered in adherence. However, the combined roles of NSDS, GNC function, and current SUDs in predicting combined antiretroviral therapy (cART) adherence remain poorly understood. Forty PLWH (70% Latina/o; 30% non-Hispanic White) completed psychiatric/SUD, neurocognitive, and self-report cART adherence evaluations...
August 23, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28987236/associations-of-cord-blood-metabolites-with-perinatal-characteristics-newborn-anthropometry-and-cord-blood-hormones-in-project-viva
#6
Wei Perng, Sheryl L Rifas-Shiman, Scott McCulloch, Leda Chatzi, Christos Mantzoros, Marie-France Hivert, Emily Oken
CONTEXT: Metabolomics has emerged as a powerful tool to characterize biomarkers and elucidate physiological processes underlying adverse health outcomes. Little is known of these relationships during gestation and infancy, which are critical period for development of metabolic disease risk. OBJECTIVES: To identify cord blood metabolite patterns associated with birth size; and to investigate relations of the birth size-associated metabolite patterns, and a branched chain amino acid (BCAA) metabolite pattern with a range of newborn and perinatal characteristics...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28985868/clinical-and-socioeconomic-factors-associated-with-negative-pediatric-appendicitis
#7
Genia Dubrovsky, Josh Rouch, Nhan Huynh, Scott Friedlander, Yang Lu, Steven L Lee
BACKGROUND: Misdiagnosing appendicitis may lead to unnecessary surgery. The study evaluates the risk factors for negative appendectomies, as well as the clinical and socioeconomic consequences of negative appendectomy across three states. MATERIALS AND METHODS: Data were obtained from the California, New York, and Florida State Inpatient Databases 2005-2011. Patients (<18 years) who underwent nonincidental appendectomies (n = 156,660) were evaluated with hierarchical and multivariate negative binomial regression analyses on outcomes including hospital cost, length of stay (LOS), and associated morbidity...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28983501/regional-variation-in-the-predictive-validity-of-self-rated-health-for-mortality
#8
Edward R Berchick, Scott M Lynch
Self-rated health (SRH) is a commonly used measure for assessing general health in surveys in the United States. However, individuals from different parts of the United States may vary in how they assess their health. Geographic differences in health care access and in the prevalence of illnesses may make it difficult to discern true regional differences in health when using SRH as a health measure. In this article, we use data from the 1986 and 1989-2006 National Health Interview Survey Linked Mortality Files and estimate Cox regression models to examine whether the relationship between SRH and five-year all-cause mortality differs by Census region...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/28978542/consumption-of-whole-eggs-promotes-greater-stimulation-of-postexercise-muscle-protein-synthesis-than-consumption-of-isonitrogenous-amounts-of-egg-whites-in-young-men
#9
Stephan van Vliet, Evan L Shy, Sidney Abou Sawan, Joseph W Beals, Daniel Wd West, Sarah K Skinner, Alexander V Ulanov, Zhong Li, Scott A Paluska, Carl M Parsons, Daniel R Moore, Nicholas A Burd
Background: Protein in the diet is commonly ingested from whole foods that contain various macro- and micronutrients. However, the effect of consuming protein within its natural whole-food matrix on postprandial protein metabolism remains understudied in humans.Objective: We aimed to compare the whole-body and muscle protein metabolic responses after the consumption of whole eggs with egg whites during exercise recovery in young men.Design: In crossover trials, 10 resistance-trained men [aged 21 ± 1 y; 88 ± 3 kg; body fat: 16% ± 1% (means ± SEMs)] received primed continuous l-[ring-(2)H5]phenylalanine and l-[1-(13)C]leucine infusions and performed a single bout of resistance exercise...
October 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28977669/stable-breathing-in-patients-with-obstructive-sleep-apnea-is-associated-with-increased-effort-but-not-lowered-metabolic-rate
#10
Camila M de Melo, Luigi Taranto-Montemurro, James P Butler, David P White, Stephen H Loring, Ali Azarbarzin, Melania Marques, Philip J Berger, Andrew Wellman, Scott A Sands
Study objectives: In principle, if metabolic rate were to fall during sleep in a patient with obstructive sleep apnea (OSA), ventilatory requirements could be met without increased respiratory effort thereby favoring stable breathing. Indeed, most patients achieve periods of stable flow-limited breathing without respiratory events for periods during the night for reasons that are unclear. Thus, we tested the hypothesis that in patients with OSA, periods of stable breathing occur when metabolic rate (VO2) declines...
July 23, 2017: Sleep
https://www.readbyqxmd.com/read/28976850/safety-and-immunogenicity-of-an-anti-zika-virus-dna-vaccine-preliminary-report
#11
Pablo Tebas, Christine C Roberts, Kar Muthumani, Emma L Reuschel, Sagar B Kudchodkar, Faraz I Zaidi, Scott White, Amir S Khan, Trina Racine, Hyeree Choi, Jean Boyer, Young K Park, Sylvie Trottier, Celine Remigio, Diane Krieger, Susan E Spruill, Mark Bagarazzi, Gary P Kobinger, David B Weiner, Joel N Maslow
Background Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection. Methods In this phase 1, open-label clinical trial, we evaluated the safety and immunogenicity of a synthetic, consensus DNA vaccine (GLS-5700) encoding the ZIKV premembrane and envelope proteins in two groups of 20 participants each. The participants received either 1 mg or 2 mg of vaccine intradermally, with each injection followed by electroporation (the use of a pulsed electric field to introduce the DNA sequence into cells) at baseline, 4 weeks, and 12 weeks...
October 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28973620/effect-of-genotype-guided-warfarin-dosing-on-clinical-events-and-anticoagulation-control-among-patients-undergoing-hip-or-knee-arthroplasty-the-gift-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Brian F Gage, Anne R Bass, Hannah Lin, Scott C Woller, Scott M Stevens, Noor Al-Hammadi, Juan Li, Tomás Rodríguez, J Philip Miller, Gwendolyn A McMillin, Robert C Pendleton, Amir K Jaffer, Cristi R King, Brandi DeVore Whipple, Rhonda Porche-Sorbet, Lynnae Napoli, Kerri Merritt, Anna M Thompson, Gina Hyun, Jeffrey L Anderson, Wesley Hollomon, Robert L Barrack, Ryan M Nunley, Gerard Moskowitz, Victor Dávila-Román, Charles S Eby
Importance: Warfarin use accounts for more medication-related emergency department visits among older patients than any other drug. Whether genotype-guided warfarin dosing can prevent these adverse events is unknown. Objective: To determine whether genotype-guided dosing improves the safety of warfarin initiation. Design, Setting, and Patients: The randomized clinical Genetic Informatics Trial (GIFT) of Warfarin to Prevent Deep Vein Thrombosis included patients aged 65 years or older initiating warfarin for elective hip or knee arthroplasty and was conducted at 6 US medical centers...
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28968152/induction-of-prp-sc-specific-systemic-and-mucosal-immune-responses-in-white-tailed-deer-with-an-oral-vaccine-for-chronic-wasting-disease
#13
Ryan Taschuk, Erin Scruten, Murray Woodbury, Neil Cashman, Andrew Potter, Philip Griebel, Suresh K Tikoo, Scott Napper
The ongoing epidemic of chronic wasting disease (CWD) within cervid populations indicates the need for novel approaches for disease management. A vaccine that either reduces susceptibility to infection or reduces shedding of prions by infected animals, or a combination of both, could be of benefit for disease control. The development of such a vaccine is challenged by the unique nature of prion diseases and the requirement for formulation and delivery in an oral format for application in wildlife settings. To address the unique nature of prions, our group targets epitopes, termed disease specific epitopes (DSEs), whose exposure for antibody binding depends on disease-associated misfolding of PrP(C) into PrP(Sc)...
September 3, 2017: Prion
https://www.readbyqxmd.com/read/28967377/intrinsic-disorder-within-akap79-fine-tunes-anchored-phosphatase-activity-toward-substrates-and-drug-sensitivity
#14
Patrick J Nygren, Sohum Mehta, Devin K Schweppe, Lorene K Langeberg, Jennifer L Whiting, Chad R Weisbrod, James E Bruce, Jin Zhang, David Veesler, John D Scott
Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins. Structural analysis by negative-stain electron microscopy (EM) reveals an ensemble of dormant AKAP79-PP2B configurations varying in particle length from 160-240 Å. A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies...
October 2, 2017: ELife
https://www.readbyqxmd.com/read/28966443/clinical-uptake-of-antimicrobial-stewardship-recommendations-following-nanosphere-verigene-blood-culture-gram-negative-reporting
#15
Aaron Belknap, Daniel S Grosser, Daniel A Hale, Benjamin J Lang, Peter Colley, Raul Benavides, Neelam Dhiman
We performed a retrospective chart review of patients to determine if the Verigene Gram-negative blood culture (BC-GN) results would lead to earlier deescalation of empiric therapy for inpatients with GN bacteremia with Citrobacter spp., Enterobacter spp., Klebsiella spp., and Escherichia coli to appropriate targeted coverage. A total of 899 records were reviewed from April 2014 to February 2016 from three institutions within the Baylor Scott & White Health network. The cases were reviewed for initial antibiotic coverage, timing of Verigene results, change in antibiotic coverage, and how these changes related to the timing of Verigene results...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28965766/differentiation-of-human-pluripotent-stem-cells-into-functional-lung-alveolar-epithelial-cells
#16
Anjali Jacob, Michael Morley, Finn Hawkins, Katherine B McCauley, J C Jean, Hillary Heins, Cheng-Lun Na, Timothy E Weaver, Marall Vedaie, Killian Hurley, Anne Hinds, Scott J Russo, Seunghyi Kook, William Zacharias, Matthias Ochs, Katrina Traber, Lee J Quinton, Ana Crane, Brian R Davis, Frances V White, Jennifer Wambach, Jeffrey A Whitsett, F Sessions Cole, Edward E Morrisey, Susan H Guttentag, Michael F Beers, Darrell N Kotton
Lung alveoli, which are unique to air-breathing organisms, have been challenging to generate from pluripotent stem cells (PSCs) in part because there are limited model systems available to provide the necessary developmental roadmaps for in vitro differentiation. Here we report the generation of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, from human PSCs. Using multicolored fluorescent reporter lines, we track and purify human SFTPC+ alveolar progenitors as they emerge from endodermal precursors in response to stimulation of Wnt and FGF signaling...
October 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28963163/cemented-total-hip-arthroplasty-following-acetabular-fracture
#17
C E H Scott, D MacDonald, M Moran, T O White, J T Patton, J F Keating
AIMS: To evaluate the outcomes of cemented total hip arthroplasty (THA) following a fracture of the acetabulum, with evaluation of risk factors and comparison with a patient group with no history of fracture. PATIENTS AND METHODS: Between 1992 and 2016, 49 patients (33 male) with mean age of 57 years (25 to 87) underwent cemented THA at a mean of 6.5 years (0.1 to 25) following acetabular fracture. A total of 38 had undergone surgical fixation and 11 had been treated non-operatively; 13 patients died at a mean of 10...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28959147/the-american-urological-association-s-prostate-cancer-screening-guideline-which-cancers-will-be-missed-in-average-risk-men-aged-40-to-54-years
#18
Thomas E Moody, Curtis L Spraitzar, Elizabeth Eisenhart, Scott Tully
To determine the impact of the American Urological Association's (AUA) guideline for early detection of prostate cancer that recommends against routine screening in men aged 40 to 54 years at average risk (eg, white men without a family history of prostate cancer), we undertook a study of 973 men who previously underwent a prostate biopsy at Urology Centers of Alabama (UCA) over the 5-year period from 2010 to 2014. We retrospectively reviewed the results of the prostate biopsies performed by urologists at UCA-and, where applicable, the final surgical pathology results and compared the results by race and family history...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28957318/use-of-rhodamine-b-to-mark-the-body-and-seminal-fluid-of-male-aedes-aegypti-for-mark-release-recapture-experiments-and-estimating-efficacy-of-sterile-male-releases
#19
Brian J Johnson, Sara N Mitchell, Christopher J Paton, Jessica Stevenson, Kyran M Staunton, Nigel Snoad, Nigel Beebe, Bradley J White, Scott A Ritchie
BACKGROUND: Recent interest in male-based sterile insect technique (SIT) and incompatible insect technique (IIT) to control Aedes aegypti and Aedes albopictus populations has revealed the need for an economical, rapid diagnostic tool for determining dispersion and mating success of sterilized males in the wild. Previous reports from other insects indicated rhodamine B, a thiol-reactive fluorescent dye, administered via sugar-feeding can be used to stain the body tissue and seminal fluid of insects...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28951270/survival-outcomes-prognostication-in-glioblastoma-diagnosed-patients
#20
Damir Nizamutdinov, Jad A Dandashi, Eileen M Stock, Eliana A Vasquez, Ying Mao, Samantha Dayawansa, Jun Zhang, Erxi Wu, Ekokobe Fonkem, Jason H Huang
OBJECTIVE: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor with most dismal survival rates. This study aims to examine the prognostic value of primary tumor sites and race on survival outcomes. METHODS: Patient data obtained from the Scott & White Hospital Brain Tumor Registry (1976 to 2013) were stratified according to sex, age, race, primary tumor site, vital status, and survival rate. RESULTS: Of the 645 patients, 580 (89...
September 23, 2017: World Neurosurgery
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