Jessica I Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L Avery, Emelia J Benjamin, Joshua C Bis, Jennifer A Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J F Loos, Ake Lu, Tara Matise, Kari E North, Sungshim L Park, Scott M Ratliff, Alex Reiner, Stephen S Rich, Jerome I Rotter, Jennifer A Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M Raffield, Charles Kooperberg
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation is an epigenetic modification in the DNA which plays a pivotal role in gene expression. In this study we evaluated differential DNA methylation patterns associated with blood CRP level to elucidate biological pathways and genetic regulatory mechanisms to improve the understanding of chronic inflammation...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society