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https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#1
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938622/profiling-cancer-related-gene-mutations-in-oral-squamous-cell-carcinoma-from-japanese-patients-by-targeted-amplicon-sequencing
#2
Takafumi Nakagaki, Miyuki Tamura, Kenta Kobashi, Ryota Koyama, Hisayo Fukushima, Tomoko Ohashi, Masashi Idogawa, Kazuhiro Ogi, Hiroyoshi Hiratsuka, Takashi Tokino, Yasushi Sasaki
Somatic mutation analysis is a standard practice in the study of human cancers to identify mutations that cause therapeutic sensitization and resistance. We performed comprehensive genomic analyses that used PCR target enrichment and next-generation sequencing on Ion Proton semiconductor sequencers. Forty-seven oral squamous cell carcinoma (OSCC) samples and their corresponding noncancerous tissues were used for multiplex PCR amplification to obtain targeted coverage of the entire coding regions of 409 cancer-related genes (covered regions: 95...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938598/proton-pump-inhibitors-increase-the-chemosensitivity-of-patients-with-advanced-colorectal-cancer
#3
Xiaoyu Wang, Chun Liu, Jiaqi Wang, Yue Fan, Zhenghua Wang, Yuanyuan Wang
Changes in pH can alter the uptake of chemotherapy drugs. Proton pump inhibitors (PPIs) may therefore increase the chemosensitivity of cancer cells and cytotoxicity of chemotherapeutic drugs by increasing their uptake. We investigated the chemosensitizing potential of PPIs in colorectal cancer (CRC). Our in vitro data show that the PPI pantoprazole increases the chemosensitivity of CRC HT29 and RKO cells to fluorouracil (5-FU). Our in vivo data demonstrate that pantoprazole also increases the ability of 5-FU to inhibit CRC tumor growth in mice...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938170/aromatic-hydrazones-derived-from-nicotinic-acid-hydrazide-as-fluorimetric-ph-sensing-molecules-structural-analysis-by-computational-and-spectroscopic-methods-in-solid-phase-and-in-solution
#4
T Benković, A Kenđel, J Parlov-Vuković, D Kontrec, V Chiş, S Miljanić, N Galić
Structural analyses of aroylhydrazones were performed by computational and spectroscopic methods (solid state NMR, 1 and 2D NMR spectroscopy, FT-IR (ATR) spectroscopy, Raman spectroscopy, UV-Vis spectrometry and spectrofluorimetry) in solid state and in solution. The studied compounds were N'-(2,3-dihydroxyphenylmethylidene)-3-pyridinecarbohydrazide (1), N'-(2,5-dihydroxyphenylmethylidene)-3-pyridinecarbohydrazide (2), N'-(3-chloro-2-hydroxy-phenylmethylidene)-3-pyridinecarbohydrazide (3), and N'-(2-hydroxy-4-methoxyphenyl-methylidene)-3-pyridinecarbohydrazide (4)...
September 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28938135/bang-bang-optimal-control-of-large-spin-systems-enhancement-of-13-c-13-c-singlet-order-at-natural-abundance
#5
Deepak Khurana, T S Mahesh
Using a bang-bang optimal control technique, we transfer polarization from a set of abundant high-γ nuclei directly to singlet order of a low-γ spin-pair. This approach is analogous to algorithmic cooling (AC) procedure used in quantum state purification. Specifically, we apply this method for enhancing the singlet order in a natural abundant (13)C- (13)C spin pair by exploiting nine equivalent protons of an 11-spin system. Compared to the standard method not involving polarization transfer, we find an enhancement of singlet order by about 3...
September 14, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28938134/long-lived-states-detect-interactions-between-small-molecules-and-diamagnetic-metal-ions
#6
Cristina Stavarache, Anamaria Hanganu, Anca Paun, Codruta Paraschivescu, Mihaela Matache, Paul R Vasos
Long-lived states of nuclear spin order were used for the first time to probe interactions between molecules and diamagnetic metal ions. Proton spin states with lifetimes twice as long as the spin-lattice relaxation time constants of the same nuclei were promoted on the methoxyphenyl and tolyl substituents of a 1,3,4-oxadiazole derivative. The transient interaction of this oxadiazole derivative with silver(I) ions significantly speeds up the relaxation rate constants of proton long-lived states. The interactions between silver and organic compounds lead to the formation of coordination polymers that can be used for the preparation of bio-compatible materials...
September 6, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28937775/operando-phonon-studies-of-the-protonation-mechanism-in-highly-active-hydrogen-evolution-reaction-pentlandite-catalysts
#7
Ioannis Zegkinoglou, Ali Zendegani, Ilya Sinev, Sebastian Kunze, Hemma Mistry, Hyo Sang Jeon, Jiyong Zhao, Michael Y Hu, E Ercan Alp, Stefan Piontek, Mathias Smialkowski, Ulf-Peter Apfel, Fritz Körmann, Jorg Neugebauer, Tilmann Hickel, Beatriz Roldan Cuenya
Synthetic pentlandite (Fe4.5Ni4.5S8) is a promising electrocatalyst for hydrogen evolution, demonstrating high current densities, low overpotential and remarkable stability in bulk form. The depletion of sulfur from the surface of this catalyst during the electrochemical reaction has been proposed to be beneficial for its catalytic performance, but the role of sulfur vacancies and the mechanism determining the reaction kinetics are still unknown. We have performed electrochemical operando studies of the vibrational dynamics of pentlandite under hydrogen evolution reaction conditions using 57Fe nuclear resonant inelastic X-ray scattering...
September 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28937771/urinary-metabolic-phenotyping-of-women-with-lower-urinary-tract-symptoms
#8
Rhiannon Bray, Stefano Cacciatore, Beatriz Jimenez, Rufus Cartwright, Alex Digesu, Ruwan Fernando, Elaine Holmes, Jeremy Kirk Nicholson, Phillip R Bennett, David A MacIntyre, Vik Khullar
Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynaecology clinics (cases; n=176) and healthy control women attending general gynecology clinics (n=36)...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28937164/a-capped-trigonal-pyramidal-molybdenum-hydrido-complex-and-an-unusually-mild-sulfur-carbon-bond-cleavage-reaction
#9
Robert H Morris
DFT calculations reveal that a reported molybdenum hydride complex has an unprecedented geometry with the molybdenum in the base of trigonal pyramid defined by three thiolate ligands with a phosphine ligand on the apex and a hydride capping a PS2 face. This complex reacts with methanol to produce a sulfido complex by a new reaction: the protonation of an ipso carbon of a thiolate ligand by coordinated methanol.
September 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28937021/optimized-high-dose-amoxicillin-proton-pump-inhibitor-dual-therapies-fail-to-achieve-high-cure-rates-in-china
#10
Jia-Li Hu, Jun Yang, Yin-Bin Zhou, Ping Li, Ran Han, Dian-Chun Fang
Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylori infection. Rabeprazole dosages for H. pylori eradication were also evaluated. PATIENTS AND METHODS: Treatment-naive and H...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937019/failure-of-optimized-dual-proton-pump-inhibitor-amoxicillin-therapy-what-now
#11
EDITORIAL
David Y Graham, Hong Lu, Akiko Shiotani
No abstract text is available yet for this article.
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936896/fat-fraction-mapping-using-magnetic-resonance-imaging-insight-into-pathophysiology
#12
Timothy J P Bray, Manil D Chouhan, Shonit Punwani, Alan Bainbridge, Margaret A Hall-Craggs
Adipose cells have traditionally been viewed as a simple, passive energy storage depot for triglycerides. However, in recent years it has become clear that adipose cells are highly physiologically active and have a multitude of endocrine, metabolic, haematological and immune functions. Changes in the number or size of adipose cells may be directly implicated in disease (for example, in the metabolic syndrome), but may also be linked to other pathological processes such as inflammation, malignant infiltration or infarction...
September 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936867/anisotropic-dye-adsorption-and-anhydrous-proton-conductivity-in-smectic-liquid-crystal-networks-the-role-of-cross-link-density-order-and-orientation
#13
Ting Liang, Huub P C van Kuringen, Dirk J Mulder, Shuai Tan, Yong Wu, Zandrie Borneman, Kitty Nijmeijer, Albertus P H J Schenning
In this work the decisive role of rigidity, orientation and order in the smectic liquid crystalline network on the anisotropic proton and adsorbent properties is reported. The rigidity in the hydrogen-bonded polymer network has been altered by changing the cross-link density, the order by using different mesophases (smectic, nematic and isotropic phases) while the orientation of the mesogens was controlled by alignment layers. Adding more cross-linker improved the integrity of the polymer films. For the proton conduction, an optimum was found in the amount of cross-linker and the smectic organization results in the highest anhydrous proton conduction...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28936768/untrapping-kinetically-trapped-ions-the-role-of-water-vapor-and-ion-source-activation-conditions-on-the-gas-phase-protomer-ratio-of-benzocaine-revealed-by-ion-mobility-mass-spectrometry
#14
Hanxue Xia, Athula B Attygalle
The role of water vapor in transforming the thermodynamically preferred species of protonated benzocaine to the less favored protomer was investigated using helium-plasma ionization (HePI) in conjunction with ion-mobility mass spectrometry (IM-MS). The IM arrival-time distribution (ATD) recorded from a neat benzocaine sample desorbed to the gas phase by a stream of dry nitrogen and ionized by HePI showed essentially one peak for the O-protonated species. However, when water vapor was introduced to the enclosed ion source, within a span of about 150 ms the ATD profile changed completely to one dominated by the N-protonated species...
September 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28936701/low-energy-collisions-of-protonated-enantiopure-amino-acids-with-chiral-target-gases
#15
K Kulyk, O Rebrov, M Ryding, R D Thomas, E Uggerud, M Larsson
Here we report on the gas-phase interactions between protonated enantiopure amino acids (L- and D-enantiomers of Met, Phe, and Trp) and chiral target gases [(R)- and (S)-2-butanol, and (S)-1-phenylethanol] in 0.1-10.0 eV low-energy collisions. Two major processes are seen to occur over this collision energy regime, collision-induced dissociation and ion-molecule complex formation. Both processes were found to be independent of the stereo-chemical composition of the interacting ions and targets. These data shed light on the currently debated mechanisms of gas-phase chiral selectivity by demonstrating the inapplicability of the three-point model to these interactions, at least under single collision conditions...
September 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28936524/proton-conduction-in-alkali-metal-ion-exchanged-porous-ionic-crystals
#16
Sayaka Uchida, Reina Hosono, Ryo Eguchi, Ryosuke Kawahara, Ryota Osuga, Junko N Kondo, Mitsuhiro Hibino, Noritaka Mizuno
Proton conduction in alkali metal ion-exchanged porous ionic crystals A2[Cr3O(OOCH)6(etpy)3]2[α-SiW12O40]·nH2O [I-A(+)] (A = Li, Na, K, Cs, etpy = 4-ethylpyridine) is investigated. Single crystal and powder X-ray diffraction measurements show that I-A(+) possesses analogous one-dimensional channels where alkali metal ions (A(+)) and water of crystallization exist. Impedance spectroscopy and water diffusion measurements of I-A(+) show that proton conductivities are low (10(-7)-10(-6) S cm(-1)) under low relative humidity (RH), and protons mostly migrate as H3O(+) with H2O as vehicles (vehicle mechanism)...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28936515/lysosomal-tracking-with-a-cationic-naphthalimide-using-multiphoton-fluorescence-lifetime-imaging-microscopy
#17
Meng Li, Haobo Ge, Vincenzo Mirabello, Rory L Arrowsmith, Gabriele Kociok-Köhn, Stanley W Botchway, Weihong Zhu, Sofia I Pascu, Tony D James
A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(iii) chloride, and maintains this property in living cancer cells. The emission response to Fe(iii) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.
September 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28936487/platelet-dense-granules-begin-to-selectively-accumulate-mepacrine-during-proplatelet-formation
#18
Hayley A Hanby, Jialing Bao, Ji-Yoon Noh, Danuta Jarocha, Mortimer Poncz, Mitchell J Weiss, Michael S Marks
Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as ADP and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activation, adhesion, and stabilization at sites of vascular damage. DGs are thought to fully mature within megakaryocytes (MKs) prior to platelet formation. Here we challenge this notion by exploiting vital fluorescent dyes to distinguish mildly acidic DGs from highly acidic compartments by microscopy in platelets and MKs...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/28935885/non-diffracting-multi-%C3%AF-electron-vortex-beams-balancing-their-electron-electron-interactions
#19
Maor Mutzafi, Ido Kaminer, Gal Harari, Mordechai Segev
The wave-like nature of electrons has been known for almost a century, but only in recent years has the ability to shape the wavefunction of EBeams (Electron-Beams) become experimentally accessible. Various EBeam wavefunctions have been demonstrated, such as vortex, self-accelerating, Bessel EBeams etc. However, none has attempted to manipulate multi-electron beams, because the repulsion between electrons rapidly alters the beam shape. Here, we show how interference effects of the quantum wavefunction describing multiple electrons can be used to exactly balance both the repulsion and diffraction-broadening...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935239/te-dependent-diffusion-imaging-teddi-distinguishes-between-compartmental-t2-relaxation-times
#20
Jelle Veraart, Dmitry S Novikov, Els Fieremans
Biophysical modeling of macroscopic diffusion-weighted MRI (dMRI) signal in terms of microscopic cellular parameters holds the promise of quantifying the integrity of white matter. Unfortunately, even fairly simple multi-compartment models of proton diffusion in the white matter do not provide a unique, biophysically plausible solution. Here we report a nontrivial diffusion MRI signal dependence on echo time (TE) in human white matter in vivo. We demonstrate that such TE dependence originates from compartment-specific T2 values and that it is a promising "orthogonal measure" able to break the degeneracy in parameter estimation, and to yield important relaxation metrics robustly...
September 18, 2017: NeuroImage
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