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https://www.readbyqxmd.com/read/29161458/proton-pump-inhibitors-for-functional-dyspepsia
#1
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Ahmed Hassan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161254/lansoprazole-use-and-tuberculosis-incidence-in-the-united-kingdom-clinical-practice-research-datalink-a-population-based-cohort
#2
Tom A Yates, Laurie A Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Ian J Douglas
BACKGROUND: Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practice, lansoprazole can treat or prevent incident tuberculosis (TB) disease. METHODS AND FINDINGS: We studied a cohort of new users of lansoprazole, omeprazole, or pantoprazole from the United Kingdom Clinical Practice Research Datalink to determine whether lansoprazole users have a lower incidence of TB disease than omeprazole or pantoprazole users...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161036/visible-light-activated-asymmetric-%C3%AE-c-h-functionalization-of-acceptor-substituted-ketones-with-1-2-dicarbonyl-compounds
#3
Jiajia Ma, Anthony R Rosales, Xiaoqiang Huang, Klaus Harms, Radostan Riedel, Olaf Wiest, Eric Meggers
We report a visible-light-activated asymmetric β-C(sp(3))-H functionalization of 2-acyl imidazoles and 2-acylpyridines with 1,2-dicarbonyl compounds (typically α-ketoesters) catalyzed by a tailored stereogenic-at-rhodium Lewis acid catalyst. The C-C bond formation products are obtained in high yields (up to 99%) and with excellent stereoselectivities (up to >20:1 dr and up to >99% ee). Experimental and computational studies support a mechanism in which a photoactivated Rh-enolate transfers a single electron to the 1,2-dicarbonyl compound followed by proton transfer and a subsequent stereocontrolled radical-radical recombination...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29160955/synthesis-and-biological-evaluation-of-pyrrolo-2-1-f-1-2-4-triazine-c-nucleosides-with-a-ribose-2-deoxyribose-and-2-3-dideoxyribose-sugar-moiety
#4
Qingfeng Li, Eveline Lescrinier, Elisabetta Groaz, Leentje Persoons, Dirk Daelemans, Piet Herdewijn, Steven De Jonghe
The synthesis of hitherto unknown pyrrolo[2,1-f][1,2,4]triazine C-nucleosides is described. Structural variations (chlorine, bromine, iodine, and cyano) were introduced at position 7 of 4-aza-7,9-dideazaadenine. In addition, pyrrolo[2,1-f][1,2,4]triazine C-nucleosides bearing a 2'-deoxy-, 2',3'-dideoxy-, and 2',3'-dehydrodideoxyribose moiety were also prepared. Among these analogues, the pyrrolo[2,1-f][1,2,4]triazine C-ribonucleosides with either a proton or cyano at position 7 of the nucleobase displayed potent cytotoxic activity in a panel of different cancer cell lines...
November 21, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29160872/zinc-ii-cobalt-ii-and-manganese-ii-networks-with-phosphoserine-ligand-synthesis-crystal-structures-and-magnetic-and-proton-conductivity-properties
#5
J Vallejo, I R Salcedo, R M P Colodrero, A Cabeza, A Switlicka, J Cano, M Viciano-Chumillas
A series of zinc(ii), cobalt(ii) and manganese(ii) coordination networks with phosphoserine ligand (H3PSer) are synthesized and characterized. Whereas in compounds 1 and 2 with the general formula [M(HPser)]n [M = Zn (1) and Co (2)], the metal(ii) ion presents a tetrahedral geometry, in [Co(HPSer)(H2O)2]n (3) and [Mn(HPSer)(H2O)]n (4), the metal(ii) ions are in a distorted octahedral geometry. The 3D frameworks are formed by inorganic layers built up from MO4 or MO6 polyhedra and phosphate groups. These layers are linked by the carboxylate groups of the phosphoserine ligand...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29160776/proton-range-verification-in-homogeneous-materials-through-acoustic-measurements
#6
Wei Nie, Kevin C Jones, Scott Petro, Alireza Kassaee, Chandra M Sehgal, Stephen Avery
Clinical proton beam quality assurance (QA) requires a simple and accurate method to measure the proton beam Bragg peak (BP) depth. Protoacoustics, the measurement of the pressure waves emitted by thermal expansion resulting from proton dose deposition, may be used to obtain the depth of the BP in a phantom by measuring the time-of-flight (TOF) of the pressure wave. Rectangular and cylindrical phantoms of different materials (aluminum, lead, and polyethylene) were used for protoacoustic studies. Four different methods for analyzing the protoacoustic signals are compared...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160775/anatomical-robust-optimization-to-account-for-nasal-cavity-filling-variation-during-intensity-modulated-proton-therapy-a-comparison-with-conventional-and-adaptive-planning-strategies
#7
Steven van de Water, Francesca Albertini, Damien Charles Weber, Ben J M Heijmen, Mischa S Hoogeman, Antony John Lomax
The aim of this study is to develop an anatomical robust optimization method for intensity-modulated proton therapy (IMPT) that accounts for interfraction variations in nasal cavity filling, and to compare it with conventional single-field uniform dose (SFUD) optimization and online plan adaptation. We included CT data of five patients with tumors in the sinonasal region. Using the planning CT, we generated for each patient 25 'synthetic' CTs with varying nasal cavity filling. The robust optimization method available in our treatment planning system 'Erasmus-iCycle' was extended to also account for anatomical uncertainties by including (synthetic) CTs with varying patient anatomy as error scenarios in the inverse optimization...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160759/sensitivity-enhancement-of-aminoglycosides-in-hydrophilic-interaction-liquid-chromatography-with-tandem-mass-spectrometry-by-post-column-addition-of-trace-sodium-acetate-in-methanol
#8
Daichi Asakawa, Masako Uemura, Takanori Sakiyama, Testuo Yamano
The development of a sensitive and accurate analytical method for monitoring aminoglycosides in food, environmental, and clinical samples is needed for many purposes. This study found that the responses of sodiated and protonated aminoglycosides in hydrophilic interaction chromatography with tandem mass spectrometry were enhanced upon addition of sodium acetate in methanol (5 mg L(-1) at a flow rate of 0.2 mL min(-1)) as a post-column reagent. The sensitivities of sodiated spectinomycin, kanamycin, gentamicins, neomycin, and amikacin were significantly higher than those of the protonated molecules...
November 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29160686/human-hair-keratin-for-biocompatible-flexible-and-transient-electronic-devices
#9
Jieun Ko, Luong Thi Hieun Nguyen, Abhijith Surendran, Bee Yi Tan, Kee Woei Ng, Wei Lin Leong
Biomaterials have been attracting attention as a useful building block for biocompatible and bioresorbable electronics due to its non-toxic property and solution processabillity. In this work, we report the integration of biocompatible keratin from human hair as dielectric layer for organic thin-film transistors (TFTs), with high performance, flexibility and transient property. The keratin dielectric layer exhibited a high capacitance value above 1.27 μF/cm2 at 20 Hz due to the formation of electrical double layer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160593/xb-or-not-xb-that-is-the-question-the-interaction-modes-of-haloimidazolium-salts-in-solution
#10
Nils Schulz, Pandian Sokkar, Elric Engelage, Severin Schindler, Mate Erdelyi, Elsa Sanchez-Garcia, Stefan Matthias Huber
We performed a comparative study on the interaction mode of 2-haloimidazolium salts with anions in solution, particularly with regard to halogen bonding, hydrogen bonding and anion-π interactions. The syntheses and solid-state analyses of a series of sterically and electronically modified 2-haloimidazolium structures is presented. Detailed isothermal titration calorimetry (ITC) measurements, quantum mechanics/molecular mechanics (QM/MM MD), classical molecular dynamics simulations (MD) and free energy calculations together with NMR were used to elucidate the binding mode in solution...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29160376/eosinophilic-esophagitis-and-proton-pump-inhibitors-is-there-a-new-link
#11
Mauro Batista de Morais
No abstract text is available yet for this article.
December 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29160312/ph-dependent-spin-state-population-and-19-f-nmr-chemical-shift-via-remote-ligand-protonation-in-an-iron-ii-complex
#12
Alexandra I Gaudette, Agnes E Thorarinsdottir, T David Harris
An Fe(II) complex that features a pH-dependent spin state population, by virtue of a variable ligand protonation state, is described. This behavior leads to a highly pH-dependent (19)F NMR chemical shift with a sensitivity of 13.9(5) ppm per pH unit at 37 °C, thereby demonstrating the potential utility of the complex as a (19)F chemical shift-based pH sensor.
November 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29159915/performance-of-a-hybrid-monte-carlo-pencil-beam-dose-algorithm-for-proton-therapy-inverse-planning
#13
Ana María Barragán Montero, Kevin Souris, Daniel Sánchez Parcerisa, Edmond Sterpin, John Aldo Lee
PURPOSE: Analytical algorithms have a limited accuracy when modelling very heterogeneous tumor sites. This work addresses the performance of a hybrid dose optimizer that combines both Monte Carlo (MC) and pencil beam (PB) dose engines to get the best trade-off between speed and accuracy for proton therapy plans. METHODS: The hybrid algorithm calculates the optimal spot weights (w) by means of an iterative optimization process where the dose at each iteration is computed by using a precomputed dose influence matrix based on the conventional PB plus a correction term c obtained from a MC simulation...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159912/nickel-0-catalyzed-hydroarylation-of-styrenes-and-1-3-dienes-with-organoborons
#14
Qi-Lin Zhou, Li-Jun Xiao, Lei Cheng, Wei-Min Feng, Mao-Lin Li, Jian-Hua Xie
The Ni-catalyzed hydroarylation of styrenes and 1,3-dienes with organoborons has been developed. The reaction offers a highly selective approach to the diarylalkanes and allylarenes under redox-neutral condition. In this hydroarylation reaction, a new strategy that uses easily available proton of methanol to generate active catalyst species Ni-H was developed. The Ni-catalyzed hydroarylation, combining with a Ir-catalyzed C-H borylation, affords a very efficient and straightforward access to retinoic acid receptor agonist...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29159885/two-stage-ionoacoustic-range-verification-leveraging-monte-carlo-and-acoustic-simulations-to-stably-account-for-tissue-inhomogeneity-and-accelerator-specific-time-structure-a-simulation-study
#15
Sarah K Patch, Daniel E M Hoff, Tyler B Webb, Lee G Sobotka, Tianyu Zhao
PURPOSE: Range errors constrain treatment planning by limiting choice of ion beam angles and requiring large margins. Ionoacoustic range verification requires recovering the location of an acoustic source from low frequency signals. A priori information is applied to stably overcome resolution limits of inverse acoustic source imaging in this simulation study. In particular, the accuracy and robustness of ionoacoustic range verification for lateral and oblique delivery of high-energy protons to the prostate is examined...
November 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159784/g2a-as-a-threshold-regulator-of-inflammatory-hyperalgesia-modulates-chronic-hyperalgesia
#16
Yeu-Shiuan Su, Yu-Fen Huang, Jen Wong, Chia-Wei Lee, Wei-Shan Hsieh, Wei-Hsin Sun
Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the inflammatory site, is a major factor contributing to pain and hyperalgesia. The receptor G2 accumulation (G2A), expressed in neurons and immune cells, responds to protons or oxidized free fatty acids such as 9-hydroxyoctadecadienoic acid produced by injured cells or oxidative stresses...
November 21, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29159347/how-do-the-interfacial-properties-of-zwitterionic-sulfobetaine-micelles-differ-from-those-of-cationic-alkyl-quaternary-ammonium-micelles-an-excited-state-proton-transfer-study
#17
Aparajita Phukon, Kalyanasis Sahu
Zwitterionic surfactants (e.g. sulfobetaine), comprising both positive and negative groups in their headgroups, are essentially electro-neutral as monomers, but their micelles preferentially uptake anions similar to cationic surfactant micelles. How do the interfacial properties (e.g. interfacial hydration or headgroup packing) of a zwitterionic micelle differ from those of a cationic micelle? For this, we investigated excited-state proton transfer (ESPT) and fluorescence anisotropy decay of an interface-localized negative fluorophore, 8-hydroxypyrene-1,3,6-trisulphonate (HPTS), and its methyl analogue, 8-methoxypyrene-1,3,6-trisulfonate (MPTS), within the micellar interfaces...
November 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29159046/imaging-of-glia-activation-in-people-with-primary-lateral-sclerosis
#18
Sabrina Paganoni, Mohamad J Alshikho, Nicole R Zürcher, Paul Cernasov, Suma Babu, Marco L Loggia, James Chan, Daniel B Chonde, David Izquierdo Garcia, Ciprian Catana, Caterina Mainero, Bruce R Rosen, Merit E Cudkowicz, Jacob M Hooker, Nazem Atassi
Background: Glia activation is thought to contribute to neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role in primary lateral sclerosis (PLS) is unknown. Objectives: To localize and measure glia activation in people with PLS compared to healthy controls (HC). Methods: Ten participants with PLS and ten age-matched HCs underwent simultaneous magnetic resonance (MR) and proton emission tomography (PET)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159012/robust-planning-for-a-patient-treated-in-decubitus-position-with-proton-pencil-beam-scanning-radiotherapy
#19
Shikui Tang, Limin Song, Jared D Sturgeon, Chang Chang
A challenging case was reported for a patient treated in decubitus position with proton pencil beam scanning. A regular robust plan with the consideration of the uncertainties of translational alignment and range accuracy cannot ensure the target coverage as revealed in two verification computed tomography (CT) scans during the first week of the treatment. The irreproducibility of daily alignment and anatomical variations in such a position is mainly due to patient's roll. To mitigate the interfractional effect on the target coverage, a novel robust optimization against the patient's angular setup uncertainties was implemented to improve the plan quality by introducing two artificial CT image sets by rolling the planning CT three degrees in both clockwise and counter-clockwise directions and adding them into robust optimization scenarios, which was shown to be an effective and simple way to mitigate target dose degradation with respect to interfractional variations...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29159011/proton-therapy-for-malignant-pleural-mesothelioma-a-three-case-series-describing-the-clinical-and-dosimetric-advantages-of-proton-based-therapy
#20
Howard Lee, Jing Zeng, Stephen R Bowen, Ramesh Rengan
Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy (IMRT) with photon therapy to achieve loco-regional control following macroscopic complete resection is challenging. Intensity-modulated proton therapy (IMPT) has been shown to be a method for achieving higher therapeutic doses while limiting exposure to organs at risk (OARs), but patient outcomes after treatment have yet to be reported...
September 20, 2017: Curēus
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