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G A P Cirrone, L Manti, D Margarone, G Petringa, L Giuffrida, A Minopoli, A Picciotto, G Russo, F Cammarata, P Pisciotta, F M Perozziello, F Romano, V Marchese, G Milluzzo, V Scuderi, G Cuttone, G Korn
Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12 C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12 C-ion clinical amenability...
January 18, 2018: Scientific Reports
N Rabhi, D Batani, G Boutoux, J-E Ducret, K Jakubowska, I Lantuejoul-Thfoin, C Nauraye, A Patriarca, A Saïd, A Semsoum, L Serani, B Thomas, B Vauzour
Responses of Fuji Imaging Plates (IPs) to proton have been measured in the range 1-200 MeV. Mono-energetic protons were produced with the 15 MV ALTO-Tandem accelerator of the Institute of Nuclear Physics (Orsay, France) and, at higher energies, with the 200-MeV isochronous cyclotron of the Institut Curie-Centre de Protonthérapie d'Orsay (Orsay, France). The experimental setups are described and the measured photo-stimulated luminescence responses for MS, SR, and TR IPs are presented and compared to existing data...
November 2017: Review of Scientific Instruments
Gloria Vilches-Freixas, Jean Michel Létang, Nicolas Ducros, Simon Rit
PURPOSE: Dual-energy computed tomography (DECT) has been presented as a valid alternative to single-energy CT to reduce the uncertainty of the conversion of patient CT numbers to proton stopping power ratio (SPR) of tissues relative to water. The aim of this work was to optimize DECT acquisition protocols from simulations of X-ray images for the treatment planning of proton therapy using a projection-based dual-energy decomposition algorithm. METHODS: We have investigated the effect of various voltages and tin filtration combinations on the SPR map accuracy and precision, and the influence of the dose allocation between the low-energy (LE) and the high-energy (HE) acquisitions...
July 4, 2017: Medical Physics
Lorenzo Torrisi, Nancy Restuccia, Irene Paterniti
BACKGROUND: Gold nanoparticles, 5-20 nm in diameter, were generated with a pulsed Nd: YAG laser at 1010 W/cm2 at solution concentrations ranging between 1-100 mg/ml. The incremental X-ray contrast imaging using gold nanoparticles was investigated and measured. The study was performed with the aim to enhance the massive absorption coefficient of X-ray radiation in the tumor for medical image quality and to improve traditional X-ray radiotherapy or proton therapy. A simulation of proton therapy improvement was conducted using a human ocular melanoma model, placed 3 cm behind the eye lens, and testing 60 MeV protons...
February 14, 2018: Recent Patents on Nanotechnology
Sha Li, Sébastien Penninckx, Linda Karmani, Anne-Catherine Heuskin, Kassandra Watillon, Riccardo Marega, Jerome Zola, Valentina Corvaglia, Geraldine Genard, Bernard Gallez, Olivier Feron, Philippe Martinive, Davide Bonifazi, Carine Michiels, Stéphane Lucas
The development of new modalities and protocols is of major interest to improve the outcome of cancer treatment. Given the appealing physical properties of protons and the emerging evidence of biological relevance of the use of gold nanoparticles (GNPs), the radiosensitization effects of GNPs (5 or 10 nm) have been investigated in vitro in combination with a proton beam of different linear energy transfer (LET). After the incubation with GNPs for 24 h, nanoparticles were observed in the cytoplasm of A431 cells exposed to 10 nm GNPs, and in the cytoplasm as well as the nucleus of cells exposed to 5 nm GNPs...
November 11, 2016: Nanotechnology
R Ferrand
The number of protontherapy facilities is still increasing rapidly with more than 30 ongoing projects and close to 60 currently under operation. Although the technology is now validated and robust, a proton facility cannot be considered as a standard radiation therapy equipment: its constraints in terms of building, services, project management are of paramount impact at the level of the hospital. Therefore, a protontherapy project must be carefully considered and prepared, which is mandatory for further fluid and efficient clinical operation...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
J Doyen, P-Y Bondiau, K Benezery, J Thariat, M Vidal, A Gérard, J Hérault, C Carrie, J-M Hannoun-Lévi
Purpose was to summarize results for proton therapy in cancer treatment. A systematic review has been done by selecting studies on the website (Medline) and using the following keywords: proton therapy, radiation therapy, cancer, chordoma, chondrosarcoma, uveal melanoma, retinoblastoma, meningioma, glioma, neurinoma, pituitary adenoma, medulloblastoma, ependymoma, craniopharyngioma and nasal cavity. There are several retrospective studies reporting results for proton therapy in cancer treatments in the following indications: ocular tumors, nasal tumors, skull-based tumors, pediatric tumors...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Lorenzo Torrisi
Au nanoparticles can be prepared inside biological solutions and incorporated in special molecules for their transport through blood, drugs and proteins up to the tumour sites or directly injected in their volume when it is possible. The Au nanoparticles are biocompatible and can be accepted locally in the organism also at relatively high concentrations. The use of Au nanoparticles injected in the tumour site enhances significantly the effective atomic number of the medium, depending on the used concentration, and consequently the proton and electron energy loss and the X-ray absorption coefficient determining an increment of the local absorbed dose during radiotherapy...
2015: Recent Patents on Nanotechnology
Jérôme Doyen, Alexander Tuan Falk, Vincent Floquet, Joël Hérault, Jean-Michel Hannoun-Lévi
PURPOSE: To review current evidence of the role of proton therapy (PT) in other tumors than skull base, sinusal/parasinusal, spinal and pediatric tumors; to determine medico-economic aspects raised by PT. MATERIAL AND METHODS: A systematic review on Medline was performed with the following keywords: proton therapy, proton beam, protontherapy, cancer; publications with comparison between PT and photon-therapy were also selected. RESULTS: In silico studies have shown superiority (better dose delivery to the target and/or to organs at risk) of PT toward photon-therapy in most of thoracic and abdominal malignant tumors...
February 2016: Cancer Treatment Reviews
A Laprie, Y Hu, C Alapetite, C Carrie, J-L Habrand, S Bolle, P-Y Bondiau, A Ducassou, A Huchet, A-I Bertozzi, Y Perel, É Moyal, J Balosso
BACKGROUND AND PURPOSE: Brain tumours are the most frequent solid tumours in children and the most frequent radiotherapy indications in paediatrics, with frequent late effects: cognitive, osseous, visual, auditory and hormonal. A better protection of healthy tissues by improved beam ballistics, with particle therapy, is expected to decrease significantly late effects without decreasing local control and survival. This article reviews the scientific literature to advocate indications of protontherapy and carbon ion therapy for childhood central nervous system cancer, and estimate the expected therapeutic benefits...
December 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
L Feuvret, V Calugaru, R Ferrand
Hadron therapy (including protons and ions) is still expanding worldwide, although still limited by the cost and thus the number of available facilities. If the historical indications remain eye melanomas, skull base tumours and paediatric tumours for protontherapy; and salivary glands, paranasal sinus and nasal cavity tumours, and soft tissue sarcomas for carbon ions, no conclusion can be drawn about the role of these modalities for other tumours, such as prostate, lung cancers. Since 2013, more than 100 clinical trials are on-going, including comparisons between advanced photons modalities, protontherapy and carbon ions therapy...
October 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
G Gambarini, V Regazzoni, E Artuso, D Giove, A Mirandola, M Ciocca
A study of the response of EBT3 films to protons has been carried out with the aim of finding a simple modality to achieve dose images in which the effect of the film sensitivity dependence on radiation LET is amended. Light transmittance images (around 630 nm) were acquired by means of a CCD camera and the difference of optical density was assumed as dosimeter response. The calibration of EBT3 film was performed by means of protons of 173.61 MeV. Some EBT3 films were exposed, in a solid-water phantom, to proton beams of three different energies (89...
October 2015: Applied Radiation and Isotopes
Lorenzo Torrisi
The insertion of gold nanoparticles in biological liquids, tissues and organs permits to increase the equivalent atomic number of the medium that, if used as target to be irradiated by ionizing radiation, permits an increment of the absorbed dose. No toxic nanoparticles, such as the Au, can be injected in the cancer tissues at different concentrations before using a localized treatment that uses energetic proton beams for radiotherapy. Due to the high density and atomic number of the used gold nanoparticles, the absorbed radiation dose can be increased to about a factor six per cent using relatively low concentration of nanoparticles injectable as solution in the tumor tissue...
2015: Recent Patents on Nanotechnology
M Khadige, D Peiffert, S Supiot
Prostate cancer radiotherapy has evolved from the old 2D technique to conformal, and then to intensity-modulated radiation therapy (IMRT) and stereotactic radiotherapy. At the same time, image-guidance (IGRT) is routinely used. New techniques such as protontherapy or carbontherapy are being developed with the objective of increased efficacy, decreased treatment duration, toxicity or cost. This review summarizes the evidence-based medicine of new technologies in the treatment of prostate cancer.
October 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
B George, D Bresson, S Bouazza, S Froelich, E Mandonnet, S Hamdi, M Orabi, M Polivka, A Cazorla, H Adle-Biassette, J-P Guichard, M Duet, E Gayat, F Vallée, C-H Canova, F Riet, S Bolle, V Calugaru, R Dendale, J-J Mazeron, L Feuvret, E Boissier, S Vignot, S Puget, C Sainte-Rose, K Beccaria
PURPOSES: To review in the literature, all the epidemiological, clinical, radiological, histological and therapeutic data regarding chordomas as well as various notochordal entities: ecchordosis physaliphora, intradural and intraparenchymatous chordomas, benign notochordal cell tumors, parachordomas and extra-axial chordomas. To identify different types of chordomas, including familial forms, associations with tuberous sclerosis, Ollier's disease and Maffucci's syndrome, forms with metastasis and seeding...
June 2014: Neuro-Chirurgie
M Saleh, J Zhang, C Benichou, C Hermsdorff, T Bourcier, A Sauer, C Speeg-Schatz, D Gaucher
PURPOSE: To report anatomical and functional results of choroidal melanoma treated by protontherapy between 2001 and 2011 and to compare these with data reported in the literature. METHODS: The present study is a retrospective review of the charts of patients presenting with choroidal melanoma, managed at Strasbourg University Medical Center between 2001 and 2011, and receiving protontherapy. Visual acuity and a complete ophthalmologic examination, including intraocular pressure, dilated fundus exam, and ultrasonography with measurement of the major diameter of the tumor, were performed prior to treatment and at various follow-up visits (every six months for five years, then once a year for ten years)...
September 2013: Journal Français D'ophtalmologie
M Berguiga, E Mameletzi, M Nicolas, D Rivier, F Majo
BACKGROUND: To evaluate the long-term efficacy of multilayer amniotic membrane transplantation for reconstruction of epithelium and stroma in non-traumatic corneal perforations (less than 2 mm) or deep ulcers with descemetocele. DESIGN: Retrospective, non-comparative, interventional case series. PATIENTS AND METHODS: Eleven consecutive patients with non-traumatic corneal perforations or deep corneal ulcers with descemetocele refractory to conventional treatments: herpetic or zoster keratitis (n = 4), Sjögren's syndrome (n = 2), rosacea (n = 1), hydrops (n = 1), mucous membrane pemphigoid (n = 1), bacterial keratitis (n = 1) and perforation after protontherapy for melanoma (n = 1)...
April 2013: Klinische Monatsblätter Für Augenheilkunde
G Vogin, M-C Biston, V Marchesi, M Amessis, L De Marzi, F Lacroix, A Leroy, F Gassa, S Zefkili, S Helfre
PURPOSE: Although radiosensitive, spinal locations of Ewing's sarcomas are challenging for the radiation oncologist due to poor radiation tolerance of the spinal cord. However, some favorable anatomical compartments - that may represent more than 20% - were associated with a better outcome and could benefit from a radiation dose escalation using the most recent radiation therapy techniques. MATERIALS AND METHODS: We performed a dose escalation study on one patient, declined in two scenarios: (1) a tumour located within a single vertebral body and (2) a locally advanced disease involving the vertebral foramen and paraspinal soft tissues...
February 2013: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Jihen Brour, Laurence Desjardins, Phuc Lehoang, Bahram Bodaghi, Livia Lumbroso-Lerouic, Remi Dendale, Nathalie Cassoux
PURPOSE: To determine the incidence and to discuss pathogenic mechanisms of sympathetic ophthalmia in patients treated for choroïdal melanoma. DESIGN: Retrospective. METHODS: We analyzed the clinical and pathological data of 4867 patients, treated for choroïdal melanoma at Institute Curie-Orsay, between 1998 and 2011. Were involved patients with uveitis of the adelphe eye filling clinical and angiographic criteria of sympathetic ophthalmia...
August 2012: Ocular Immunology and Inflammation
G Angellier, M Gautier, J Herault
PURPOSE: In protontherapy, accessories are used in order to adapt the beam to the surface and to the depth of the target. They are positioned close to the patient in order to avoid perturbation effects related to proton scattering. The level of contamination of the beam caused by these accessories may be assessed by examining the dose maps in parallel planes to the beam incidence. The EBT2 radiochromic film is a suitable tool for this task, as it can be cut into small pieces and immersed in water...
November 2011: Medical Physics
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