Lalit K Beura, Sara E Hamilton, Kevin Bi, Jason M Schenkel, Oludare A Odumade, Kerry A Casey, Emily A Thompson, Kathryn A Fraser, Pamela C Rosato, Ali Filali-Mouhim, Rafick P Sekaly, Marc K Jenkins, Vaiva Vezys, W Nicholas Haining, Stephen C Jameson, David Masopust
Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immune system, which may account for failures to translate disease treatments from bench to bedside...
April 28, 2016: Nature