Hao Xu, Chang Peng Chai, Huan Tang, Yuan Hui Su, Cheng Yu, Lu Li, Jian Feng Yi, Zhen Zhen Ye, Zheng Feng Wang, Jin Jing Hu, Wei Luo, Hui Zhang, Xin Miao, Wen Ce Zhou
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignant tumor of the biliary tract that is prone to recurrence and metastasis and is characterized by poor sensitivity to chemotherapy and overall prognosis. For these reasons, there is an urgent need to understand its pathological mechanisms and develop effective treatments. To address this challenge, the establishment of suitable preclinical models is critical. METHODS: Fresh ICC tissue samples were used for primary culture and subculture...
February 2024: World Journal of Oncology