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Rainer W Friedrich, Anastasios Moressis, Thomas Frank
No abstract text is available yet for this article.
February 2014: Nature Neuroscience
Rainer W Friedrich
High-resolution tracing of projections from the olfactory bulb to its cortical targets revealed coarse topography and stereotopy in some areas but highly distributed, combinatorial connectivity in others. These results provide a basis for understanding innate and associative olfactory processing and perception.
June 7, 2011: Current Biology: CB
M I Sweeney, M E Lyon
The objective of this study was to compare the neurotoxic effects of acute malathion exposure with the potential blood coagulation effects. We administered various doses of malathion to Wistar rats by i.p. injection, and then we assessed the effects on blood coagulation screening tests and activity in the open field locomotor test. The activated partial thromboplastin time (APTT), but not the prothrombin time (PT), was significantly prolonged by up to 6.6 seconds (38% of the preinjection value) after the administration of malathion (3-75 mg/kg; 1-25% of the LD50)...
1999: Journal of Environmental Pathology, Toxicology and Oncology
G I Elmer, A Brockington, D A Gorelick, F I Carrol, K C Rice, D Matecka, S R Goldberg, R B Rothman
Repeated administration of cocaine will cross-sensitize the locomotor response to a variety of psychomotor stimulants. The ability of cocaine to cross-sensitize the locomotor effects of other psychomotor stimulants provides information relevant to the pharmacological mechanisms underlying the sensitization process. The purpose of the current experiment was to investigate the ability of cocaine to cross-sensitize the locomotor effects of several dopamine uptake blockers with unique pharmacological profiles. Cocaine (40 mg/kg, IP) or saline was administered prior to a locomotor session on day one...
April 1996: Pharmacology, Biochemistry, and Behavior
K A Moore, A H Lichtman, A Poklis, J F Borzelleca
Methamphetamine is a popular drug of abuse, readily synthesized in clandestine laboratories. Illicitly obtained methamphetamine is frequently impure, containing various purposefully added diluents and adulterants, as well as impurities of manufacture and origin. Few impurities have been studied in vivo and limited information exists concerning their pharmacology/toxicology. One such impurity of manufacture is alpha-benzyl-N-methylphenethylamine (BNMPA). Acute toxicity and spontaneous activity (locomotor) studies were conducted with this compound alone and in combination with S(+)-methamphetamine (METH) in male, ICR mice...
August 1995: Drug and Alcohol Dependence
J P Yevich, J S New, W G Lobeck, P Dextraze, E Bernstein, D P Taylor, F D Yocca, M S Eison, D L Temple
A series of 1-(pyrimidin-2-yl)piperazine derivatives were prepared and evaluated in receptor binding assays and in in vivo behavioral paradigms as potential atypical antipsychotic agents. Compound 16 (BMS 181100 (formerly BMY 14802)) emerged as the lead compound from within the series on the basis of its good activity and duration of action in the inhibition of both conditioned avoidance responding and apomorphine-induced stereotopy in the rat. Compound 16 not only failed to induce catalepsy in the rat but was quite effective in reversing the cataleptic effect of neuroleptic agents, thus indicating a low propensity for causing extrapyramidal side effects...
November 27, 1992: Journal of Medicinal Chemistry
F A Collins, D L Murphy, A L Reiss, K B Sims, J G Lewis, L Freund, F Karoum, D Zhu, I H Maumenee, S E Antonarakis
Norrie disease is a rare X-linked recessive disorder characterized by blindness from infancy. The gene for Norrie disease has been localized to Xp11.3. More recently, the genes for monoamine oxidase (MAOA, MAOB) have been mapped to the same region. This study evaluates the clinical, biochemical, and neuropsychiatric data in an affected male and 2 obligate heterozygote females from a single family with a submicroscopic deletion involving Norrie disease and MAO genes. The propositus was a profoundly retarded, blind male; he also had neurologic abnormalities including myoclonus and stereotopy-habit disorder...
January 1, 1992: American Journal of Medical Genetics
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