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https://www.readbyqxmd.com/read/27906614/development-of-new-forms-of-self-injurious-behavior-following-total-dental-extraction-in-lesch-nyhan-disease
#1
Livia Gisbert de la Cuadra, Rosa J Torres, Luis M Beltrán, Arantxa Sánchez, Juan G Puig
We report two Lesch-Nyhan Disease (LND) patients who developed new forms of self-injurious behavior following total dental extraction. Patients 1 and 2 were submitted to total teeth extraction at the age of 13 and 8 years, respectively, due to continuous self-biting, not prevented by mouth guards. Severity of dystonia was markedly reduced and quality of life improved. After 12 and 17 months, respectively, patient 1 started rubbing one foot against other and scratching toenails with his hands, and patient 2 stuck his legs and feet against hard objects...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27217100/the-role-of-anxiety-in-vulnerability-for-self-injurious-behaviour-studies-in-a-rodent-model
#2
X Yuan, D P Devine
Self-injurious behaviour (SIB) is a debilitating characteristic that is highly prevalent in autism and other neurodevelopmental disorders. Pathological anxiety is also common, and there are reports of comorbid anxiety and self-injury in some children. We have investigated potential interactions between anxiety and self-injury, using a rat model of pemoline-induced self-biting. In one experiment, rats were pre-screened for trait anxiety by measuring expression of anxiety-related behaviour on the elevated plus maze and open field emergence test...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27179999/a-double-blind-placebo-controlled-crossover-trial-of-the-selective-dopamine-d1-receptor-antagonist-ecopipam-in-patients-with-lesch-nyhan-disease
#3
Tanya Khasnavis, Rosa J Torres, Barbara Sommerfeld, Juan Garcia Puig, Richard Chipkin, H A Jinnah
Lesch-Nyhan disease (LND) is a genetic disorder that has characteristic metabolic, neurologic, and behavioral features. There are multiple behavioral problems including impulsivity, aggressiveness, and severe recurrent self-injurious behavior (SIB). This last behavior varies considerably across subjects and may encompass self-biting, self-hitting, scratching, head banging, and other injurious actions. Current treatments for SIB involve behavioral extinction, sedatives, physical restraints, and removal of teeth...
July 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26922636/a-clinical-trial-of-safety-and-tolerability-for-the-selective-dopamine-d1-receptor-antagonist-ecopipam-in-patients-with-lesch-nyhan-disease
#4
Tanya Khasnavis, Gail Reiner, Barbara Sommerfeld, William L Nyhan, Richard Chipkin, H A Jinnah
Lesch-Nyhan disease (LND) is an inherited metabolic disorder characterized by the overproduction of uric acid and distinct behavioral, cognitive, and motor abnormalities. The most challenging clinical problem is self-injurious behavior (SIB), which includes self-biting, self-hitting, self-abrasion, and other features. Currently, these behaviors are managed by behavioral extinction, sedatives, physical restraints, and removal of teeth. More effective treatments are needed. Pre-clinical studies have led to the hypothesis that D1-dopamine receptor antagonists may provide useful treatments for SIB in LND...
April 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26659907/management-of-bite-wounds-in-children-and-adults-an-analysis-of-over-5000-cases-at-a-level-i-trauma-centre
#5
Manuela Jaindl, Gerhard Oberleitner, Georg Endler, Christiane Thallinger, Florian M Kovar
BACKGROUND: Bite wounds are among the commonest types of trauma to which man is the subject. They account for 5 % of the total traumatic wounds evaluated in the emergency department (ED) and approximately 1 % of all the ED visits. Early estimation of infection risk, adequate antibiotic therapy and if indicated surgical treatment are the cornerstones of successful cure of bite wounds. METHODS: A total of 5248 consecutive trauma patients were collected prospectively and analysed retrospectively over a period of 15 years in this study at a level I trauma centre, Department of Trauma Surgery, Medical University of Vienna, Austria...
May 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/26125804/correlation-analysis-between-single-nucleotide-polymorphism-of-drd1-gene-and-stereotyped-behavior-of-blue-fox
#6
Z Y Liu, E J Ren, H X Ba, Q Wu, H W Zhu, X M Xing, F H Yang
This study was performed to investigate the correlation between stereotyped behavior of the blue fox and single nucleotide polymorphisms (SNPs) of the DRD1 gene. We choose the DRD1 gene as a major gene for investigating the correlation of gene polymorphism and self-biting disease by means of direct sequencing. Part of the DRD1 gene exon of the blue fox was cloned; the length of the whole sequence was 864 bp. Four SNPs were detected and analyzed by the chi-square analysis; the results showed that the gene polymorphism of T206C in the DRD1 gene had a significant correlation with self-biting (P < 0...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25462502/stereotyped-behaviors-predicting-self-injurious-behavior-in-individuals-with-intellectual-disabilities
#7
Lucy Barnard-Brak, Johannes Rojahn, David M Richman, Steven R Chesnut, Tianlan Wei
We examined the relation between stereotyped behavior and self-injurious behavior (SIB) for 1871 individuals with intellectual disabilities who had a score of >0 on the Behavior Problem Inventory (BPI-01; Rojahn et al., 2001). We report three main findings: First, structural equation modeling techniques (SEM) revealed that the BPI-01stereotyped behavior subscale scores predicted BPI-01 SIB subscale scores. Second, when stereotyped behavior was modeled as a predictor of SIB, mixture-modeling techniques revealed two groups of individuals: one in which stereotyped behavior was a strong, statistically significant predictor of SIB (69% of the sample), and another one in which stereotyped behavior was not a predictor of SIB (31%)...
November 11, 2014: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/25419535/consequences-of-delayed-dental-extraction-in-lesch-nyhan-disease
#8
Emily M Goodman, Rosa J Torres, Juan G Puig, H A Jinnah
Patients with Lesch-Nyhan disease (LND) often engage in self-injurious biting. This problem requires difficult management choices, sometimes including removal of the teeth. Although many health care professionals are reluctant to remove teeth in a child because of the permanent negative cosmetic consequences of the edentulous state, disfigurement of the face and tongue from self-biting can be worse. We analyzed the records of 5 LND patients who used mouth guards to spare the teeth. Success was variable, and dental extraction ultimately was required in 4 cases...
September 2014: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/24748827/the-association-between-self-injurious-behaviors-and-autism-spectrum-disorders
#9
REVIEW
Noha F Minshawi, Sarah Hurwitz, Jill C Fodstad, Sara Biebl, Danielle H Morriss, Christopher J McDougle
A key area of concern in children with autism spectrum disorders (ASDs) are self-injurious behaviors (SIBs). These are behaviors that an individual engages in that may cause physical harm, such as head banging, or self-biting. SIBs are more common in children with ASD than those who are typically developing or have other neurodevelopmental disabilities. Therefore, it is important that clinicians who work with children with ASD have a solid understanding of SIB. The purpose of this paper is to review the research on the epidemiology of SIB in children with ASD, factors that predict the presence of SIB in this population, and the empirically supported behavioral treatments available...
2014: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/24323406/abnormal-behavior-and-associated-risk-factors-in-captive-baboons-papio-hamadryas-spp
#10
Corrine K Lutz, Priscilla C Williams, R Mark Sharp
Abnormal behavior, ranging from motor stereotypies to self-injurious behavior, has been documented in captive nonhuman primates, with risk factors including nursery rearing, single housing, and veterinary procedures. Much of this research has focused on macaque monkeys; less is known about the extent of and risk factors for abnormal behavior in baboons. Because abnormal behavior can be indicative of poor welfare, either past or present, the purpose of this study was to survey the presence of abnormal behavior in captive baboons and to identify potential risk factors for these behaviors with an aim of prevention...
April 2014: American Journal of Primatology
https://www.readbyqxmd.com/read/24303739/-orthodontic-silicone-positioner-for-the-treatment-of-oral-symptoms-in-amyotrophic-lateral-sclerosis-als-patients
#11
N Yavnai, D Aizenbud
ALS is considered a neurodegenerative disorder caused by progressive death of specific neuronal populations within the gray matter of the central nervous system. The cause of cell death is unknown and patients with ALS will live 3 to 5 years from disease onset. A common cause of death is neuromuscular respiratory failure or cardiac arrhythmias due to insufficient oxygen. The patients develop multiple symptoms and the focus of management is to maintain their quality of life. Orofacial manifestations in ALS are secondary to motor deficits, resulting in dysphagia, muscle spasticity, rigidity and tremor of the orofacial musculature, which can induce soft tissue trauma and sialorrhea...
July 2013: Journal of the Israel Dental Association
https://www.readbyqxmd.com/read/23640705/risk-factors-for-stereotypic-behavior-and-self-biting-in-rhesus-macaques-macaca-mulatta-animal-s-history-current-environment-and-personality
#12
Daniel H Gottlieb, John P Capitanio, Brenda McCowan
Captive rhesus macaques sometimes exhibit undesirable abnormal behaviors, such as motor stereotypic behavior (MSB) and self-abuse. Many risk factors for these behaviors have been identified but the list is far from comprehensive, and large individual differences in rate of behavior expression remain. The goal of the current study was to determine which experiences predict expression of MSB and self-biting, and if individual differences in personality can account for additional variation in MSB expression. A risk factor analysis was performed utilizing data from over 4,000 rhesus monkeys at the California National Primate Research Center...
October 2013: American Journal of Primatology
https://www.readbyqxmd.com/read/22244737/self-injury-in-people-with-intellectual-disability-and-epilepsy-a-matched-controlled-study
#13
Serafino Buono, Fabio Scannella, Maria Bernadette Palmigiano, Maurizio Elia, Mike Kerr, Santo Di Nuovo
We aimed to identify the presence of self-injurious behavior in a sample of 158 people with intellectual disability and epilepsy as compared with a control sample consisting of 195 people with intellectual disability without epilepsy. The Italian Scale for the Assessment of self-injurious behaviors was used to describe self-injurious behavior in both groups. The groups were matched for ID degree: mild/moderate (20 and 20 respectively), severe/profound (45 in both samples) and unknown (4 in both samples). Seventy-four percent of the first sample were diagnosed with symptomatic partial epilepsy...
April 2012: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/21462233/early-social-experience-affects-behavioral-and-physiological-responsiveness-to-stressful-conditions-in-infant-rhesus-macaques-macaca-mulatta
#14
Ina Rommeck, John P Capitanio, Sarah C Strand, Brenda McCowan
Studies on early development have demonstrated the profound effects of early social experience on the behavioral development and physiology of young rhesus macaques. Given these relationships, we hypothesized that rhesus macaques exposed to different nursery-rearing conditions may develop unique biobehavioral profiles. If this is true, the assessment of temperament may allow us to pinpoint successful rearing environments, thus improving the overall health of nonhuman primates that are raised in captive environments...
July 2011: American Journal of Primatology
https://www.readbyqxmd.com/read/21078074/effective-treatment-of-self-injurious-oral-trauma-in-lesch-nyhan-syndrome-a-case-report
#15
Aristidis Arhakis, Nikolaos Topouzelis, Eleni Kotsiomiti, Nikolaos Kotsanos
Lesch-Nyhan syndrome (LNS) is an X-linked disorder originating from deficiency of the enzyme hypoxanthine guanine phosphoribosyl transferase. It is characterized by neurological manifestations, including the dramatic symptom of compulsive self-mutilation, which results in destruction of oral and perioral tissues. Several drug trials have been administered to improve the severe self-destructive behaviour, with questionable effectiveness. Invasive treatment approaches, such as extraction of teeth and orthognathic surgery, have been suggested with variable success...
December 2010: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/20568078/floating-limb-behaviors-and-self-biting-are-associated-in-laboratory-monkeys
#16
Kathy L Bentson, Carolyn M Crockett, Kimberly L Wahl, Erik P Runeson, Rita U Bellanca, Grace H Lee, Jinhee P Thom, Heather B Montgomery, Monica H Yi, Julia G S McComas, James C Ha
Early descriptions of floating limb behaviors in monkeys were associated with isolation rearing, a practice that ended more than two decades ago. The present authors named various forms of behaviors in which a leg is elevated for no apparent reason: "Floating Limb Suite" (FLS). Floating limb behaviors, identified in laboratory monkeys at the Washington National Primate Research Center (WaNPRC), consist of two subcategories distinguished by whether monkeys seem to react to the elevated leg or ignore it. Given the past association of isolation rearing with both self-biting (SB) and floating limb, the investigators predicted that SB and FLS would be associated in monkeys not reared in isolation...
August 2010: American Journal of Primatology
https://www.readbyqxmd.com/read/20514183/functional-analysis-and-treatment-of-self-injury-in-a-captive-olive-baboon
#17
Nicole R Dorey, Jesús Rosales-Ruiz, Richard Smith, Bryan Lovelace
Self-injurious behavior (SIB), such as self-biting and head banging, has been reported to occur in approximately 10% of captive, individually housed nonhuman primates. Accounts of the etiology of SIB in primates range from ecological to physiological. However, to date, no research has examined the possible influence of social consequences delivered by handlers and keepers in the maintenance of SIB in this population. The current study investigated the effects of social contact as a potentially reinforcing consequence for the SIB displayed by an olive baboon (Papio hamadryas anubis)...
2009: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/20059554/tph2-5-and-3-regulatory-polymorphisms-are-differentially-associated-with-hpa-axis-function-and-self-injurious-behavior-in-rhesus-monkeys
#18
G-L Chen, M A Novak, J S Meyer, B J Kelly, E J Vallender, G M Miller
Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is linked to numerous behavioral traits. We have previously characterized the functionality of polymorphisms (especially 2051A>C) in 3'-untranslated region (3'-UTR) of rhesus monkey TPH2 (rhTPH2). This study further assessed the functionality of additional polymorphisms (-1605T>C, -1491Tn, -1485(AT)n, -1454A>G, -1325In>Del and -363T>G) in rhTPH2 5'-flanking region (5'-FR), and evaluated the effects of rhTPH2 5' and 3' genotypes on central serotonin turnover, hypothalamic-pituitary-adrenal (HPA) axis function and self-injurious behavior (SIB) in 32 unrelated adult male monkeys of Indian origin...
April 2010: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/19837095/the-anxiogenic-drug-fg7142-increases-self-injurious-behavior-in-male-rhesus-monkeys-macaca-mulatta
#19
Christine A Major, Brian J Kelly, Melinda A Novak, Matthew D Davenport, Karen M Stonemetz, Jerrold S Meyer
AIMS: Self-injurious behavior (SIB), which is deliberate infliction of self-injury without suicidal intent, is a significant human health problem. SIB is not unique to humans but is also manifested in a small percentage of captive macaques, typically as self-directed biting. Although the onset and maintenance of SIB have been linked to increased anxiety in both humans and nonhuman primates, no previous studies have directly tested the anxiety-SIB hypothesis. Here, we determined whether rhesus monkeys increase their self-directed biting following a challenge with the anxiogenic compound N-methyl-beta-carboline-3-carboxamide (FG7142)...
November 18, 2009: Life Sciences
https://www.readbyqxmd.com/read/19653949/the-effects-of-four-nursery-rearing-strategies-on-infant-behavioral-development-in-rhesus-macaques-macaca-mulatta
#20
COMPARATIVE STUDY
Ina Rommeck, Daniel H Gottlieb, Sarah C Strand, Brenda McCowan
Nursery rearing is the single most important risk factor in the development of severe forms of abnormal behavior, such as self-biting, in rhesus macaques. This practice is common in research laboratories and typically involves continuous pair housing of infants without maternal contact. We examined the effects of variation in peer socialization on the behavioral development of rhesus infants by exposing 32 newborn infants to 4 different socialization routines: continuously paired; intermittently paired; continuously paired rotationally (partners rotated within the group once a week); and intermittently paired rotationally...
July 2009: Journal of the American Association for Laboratory Animal Science: JAALAS
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