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https://www.readbyqxmd.com/read/28453432/multiregional-radiogenomic-assessment-of-prostate-microenvironments-with-multiparametric-mr-imaging-and-dna-whole-exome-sequencing-of-prostate-glands-with-adenocarcinoma
#1
Neema Jamshidi, Daniel J Margolis, Steven Raman, Jiaoti Huang, Robert E Reiter, Michael D Kuo
Purpose To assess the underlying genomic variation of prostate gland microenvironments of patients with prostate adenocarcinoma in the context of colocalized multiparametric magnetic resonance (MR) imaging and histopathologic assessment of normal and abnormal regions by using whole-exome sequencing. Materials and Methods Six patients with prostate adenocarcinoma who underwent robotic prostatectomy with whole-mount preservation of the prostate were identified, which enabled spatial mapping between preoperative multiparametric MR imaging and the gland...
April 28, 2017: Radiology
https://www.readbyqxmd.com/read/28445160/association-between-mmp2-1306-c-t-polymorphism-and-prostate-cancer-susceptibility-a-meta-analysis-based-on-3906-subjects
#2
Kaiping Zhang, Xianguo Chen, Jun Zhou, Cheng Yang, Meng Zhang, Min Chao, Li Zhang, Chaozhao Liang
Numerous investigations have addressed the correlation between MMP2-1306C/T polymorphism and prostate cancer (PCa) susceptibility. However, these conclusions were controversial. Thus, we conducted this current meta-analysis based on six studies from PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI) up to October 21st, 2016. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations. Additionally, different subgroup analyses and publication bias tests were performed...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443144/modern-day-prostate-cancer-is-not-meaningfully-associated-with-lower-urinary-tract-symptoms-analysis-of-a-propensity-score-matched-cohort
#3
Amar Bhindi, Bimal Bhindi, Girish S Kulkarni, Robert J Hamilton, Ants Toi, Theodorus H van der Kwast, Andrew Evans, Alexandre R Zlotta, Antonio Finelli, Neil E Fleshner
INTRODUCTION: We sought to determine if prostate cancer (PCa) is associated with worse lower urinary tract symptoms (LUTS) than matched benign prostates, with attention to cancer characteristics, in a contemporary cohort. METHODS: Using a single-institution database (January 1, 2009-June 30, 2013), men diagnosed with PCa on biopsy and controls with negative biopsies were matched 1:1 on age, prostate volume, and a propensity score predicting the probability of PCa diagnosis...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28442277/prostate-brachytherapy-either-alone-or-in-combination-with-external-beam-radiation-is-associated-with-longer-overall-survival-in-men-with-favorable-pathologic-group-4-gleason-score-8-prostate-cancer
#4
Matthew W Jackson, Arya Amini, Bernard L Jones, Brian Kavanagh, Paul Maroni, Steven J Frank, Usama Mahmood, Rajat J Kudchadker, Thomas J Pugh
PURPOSE: Conventional prostate cancer risk stratification results in considerable heterogeneity within each prognostic group. Men with pathologic grade Group 4 (Gleason score 8) but otherwise low-risk features have been identified as a favorable subset of high-risk prostate cancer. Given recent randomized data supporting improved cancer outcome with brachytherapy in intermediate- and high-risk prostate cancer, we sought to evaluate brachytherapy utilization and overall survival (OS) for these patients...
April 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28440322/does-mpmri-improve-clinical-criteria-in-selecting-men-with-prostate-cancer-for-active-surveillance
#5
K J Tay, R T Gupta, J Holtz, R K Silverman, E Tsivian, A Schulman, J W Moul, T J Polascik
BACKGROUND: Active surveillance (AS) has excellent short to medium term outcomes in well-selected prostate cancer patients. Traditional biopsy-based selection criteria have been criticized for inaccurate determination of cancer grade and extent. We evaluated the incremental benefit of multiparametric magnetic resonance imaging (mpMRI) in patient selection using various AS criteria. METHODS: We retrospectively evaluated men who received mpMRI before radical prostatectomy between 2011 and 2014...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28440321/association-of-comorbid-disease-burden-at-diagnosis-with-higher-tumor-grade-in-men-with-non-metastatic-prostate-cancer
#6
T J Daskivich, C J Dru, D Skarecky, T Ahlering, S J Freedland
BACKGROUND: While older age is associated with higher tumor grade, it is unknown whether comorbid disease burden has a similar, independent association. We sought to evaluate the impact of comorbid disease burden on tumor grade at diagnosis as indicated by biopsy Gleason score. METHODS: We conducted an observational cohort study of 1260 men newly diagnosed with non-metastatic prostate cancer from 1998 to 2004 at two Veterans Affairs Medical Centers. Multivariable ordinal and multinomial logistic regression were used to evaluate the association between Charlson Comorbidity Index score and biopsy Gleason score...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28438628/diagnostic-accuracy-of-64-cu-psma-pet-ct-for-primary-lymph-node-staging-of-intermediate-to-high-risk-prostate-cancer-our-preliminary-experience
#7
Francesco Cantiello, Vincenzo Gangemi, Giuseppe Lucio Cascini, Ferdinando Calabria, Marco Moschini, Matteo Ferro, Gennaro Musi, Salvatore Butticè, Andrea Salonia, Alberto Briganti, Rocco Damiano
OBJECTIVE: To assess the diagnostic accuracy of (64)Copper Prostate-Specific Membrane Antigen ((64)Cu PSMA) positron emission tomography/computed tomography (PET/CT) in the primary lymph node (LN) staging of a selected cohort of intermediate-high risk Prostate Cancer (PCa) patients. MATERIALS AND METHODS: An observational prospective study was performed in 23 patients with intermediate-high risk PCa, who underwent (64)Cu-PSMA PET/CT for local and lymph nodal staging before laparoscopic radical prostatectomy (LRP) with an extended pelvic LN dissection...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28436357/prostate-cancer-detection-following-diagnosis-of-atypical-small-acinar-proliferation
#8
Kyle J Ericson, Hannah C Wenger, Alexandre M Rosen, Kyle J Kiriluk, Glenn S Gerber, Gladell P Paner, Scott E Eggener
INTRODUCTION: To report the incidence and characteristics of cancer following a diagnosis of atypical small acinar proliferation (ASAP) and comment on current clinical practice recommendations. MATERIALS AND METHODS: We reviewed patients that underwent prostate biopsy between 2008 and 2013 at a single institution. Men with ASAP without previous cancer were included. Clinicopathologic features including prostate-specific antigen (PSA), presence of ASAP or cancer, tumor volume, number of involved cores, and Gleason score were analyzed in men that received a repeat prostate biopsy...
April 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28421726/selection-criteria-for-active-surveillance-of-patients-with-prostate-cancer-in-korea-a-multicenter-analysis-of-pathology-after-radical-prostatectomy
#9
Chang Wook Jeong, Sung Kyu Hong, Seok Soo Byun, Seong Soo Jeon, Seong Il Seo, Hyun Moo Lee, Hanjong Ahn, Dong Deuk Kwon, Hong Koo Ha, Tae Gyun Kwon, Jae Seung Chung, Cheol Kwak, Hyung Jin Kim
Purpose: Korean patients with prostate cancer (PC) typically present with a more aggressive disease than patients in Western populations. Consequently, it is unclear if the current criteria for active surveillance (AS) can safely be applied to Korean patients. Therefore, this study was conducted to define appropriate selection criteria for AS for patients with PC in Korea. Materials and Methods: We conducted a multicenter retrospective study of 2126 patients with low risk PC who actually underwent radical prostatectomy...
April 14, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28420168/comparative-study-of-blood-based-biomarkers-%C3%AE-2-3-sialic-acid-psa-and-phi-for-high-risk-prostate-cancer-detection
#10
Montserrat Ferrer-Batallé, Esther Llop, Manel Ramírez, Rosa Núria Aleixandre, Marc Saez, Josep Comet, Rafael de Llorens, Rosa Peracaula
Prostate Specific Antigen (PSA) is the most commonly used serum marker for prostate cancer (PCa), although it is not specific and sensitive enough to allow the differential diagnosis of the more aggressive tumors. For that, new diagnostic methods are being developed, such as PCA-3, PSA isoforms that have resulted in the 4K score or the Prostate Health Index (PHI), and PSA glycoforms. In the present study, we have compared the PHI with our recently developed PSA glycoform assay, based on the determination of the α2,3-sialic acid percentage of serum PSA (% α2,3-SA), in a cohort of 79 patients, which include 50 PCa of different grades and 29 benign prostate hyperplasia (BPH) patients...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28417979/longitudinal-assessment-of-urinary-pca3-for-predicting-prostate-cancer-grade-reclassification-in-favorable-risk-men-during-active-surveillance
#11
J J Tosoian, H D Patel, M Mamawala, P Landis, S Wolf, D J Elliott, J I Epstein, H B Carter, A E Ross, L J Sokoll, C P Pavlovich
BACKGROUND: To assess the utility of urinary prostate cancer antigen 3 (PCA3) as both a one-time and longitudinal measure in men on active surveillance (AS). METHODS: The Johns Hopkins AS program monitors men with favorable-risk prostate cancer with serial PSA, digital rectal examination (DRE), prostate magnetic resonance imaging and prostate biopsy. Since 2007, post-DRE urinary specimens have also been routinely obtained. Men with multiple PCA3 measures obtained over ⩾3 years of monitoring were included...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28415720/the-function-of-oxytocin-a-potential-biomarker-for-prostate-cancer-diagnosis-and-promoter-of-prostate-cancer
#12
Huan Xu, Shi Fu, Qi Chen, Meng Gu, Juan Zhou, Chong Liu, Yanbo Chen, Zhong Wang
PURPOSE: To measure the level of oxytocin in serum and prostate cancer (PCa) tissue and study its effect on the proliferation of PCa cells. RESULTS: Oxytocin level in serum was significantly increased in PCa patients compared with the no-carcinoma individuals. Additionally, the levels of oxytocin and its receptor were also elevated in the PCa tissue. However, no significant difference existed among the PCa of various Gleason grades. Western blot analysis confirmed the previous results and revealed an increased expression level of APPL1...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415558/family-with-sequence-similarity-13c-fam13c-overexpression-is-an-independent-prognostic-marker-in-prostate-cancer
#13
Christoph Burdelski, Laura Borcherding, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Ronald Simon, Christina Möller-Koop, Philipp Weigand, Sarah Minner, Alexander Haese, Hans Uwe Michl, Maria Christina Tsourlakis, Frank Jacobsen, Andrea Hinsch, Corinna Wittmer, Patrick Lebok, Stefan Steurer, Jakob R Izbicki, Guido Sauter, Till Krech, Franziska Büscheck, Till Clauditz, Thorsten Schlomm, Waldemar Wilczak
FAM13C, a gene with unknown function is included in several mRNA signatures for prostate cancer aggressiveness. To understand the impact of FAM13C on prognosis and its relationship to molecularly defined subsets, we analyzed FAM13C expression by immunohistochemistry on a tissue microarray containing 12,400 prostate cancer specimens. Results were compared to phenotype, ERG status, genomic deletions of 3p, 5q, 6q and PTEN, and biochemical recurrence. FAM13C was detectable in cell nuclei of cancerous and non-neoplastic prostate cells...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#14
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28408337/is-bmi-the-best-adiposity-measure-for-prostate-cancer-risk-results-from-a-va-biopsy-cohort
#15
Lourdes Guerrios-Rivera, Lauren Howard, Jennifer Frank, Amanda De Hoedt, Devon Beverly, Delores J Grant, Cathrine Hoyo, Stephen J Freedland
OBJECTIVES: To test multiple adiposity measures and prostate cancer (PC) risk in men undergoing prostate biopsy. We hypothesized that BMI, body fat and waist circumference would be highly correlated and all would be associated with aggressive PC, but not overall risk. SUBJECTS AND METHODS: A case (483) -control (496) study among men undergoing prostate biopsy from 2007-2016 was conducted at the Durham Veterans Affairs Medical Center. Anthropometric measurements and self-reported were taken...
April 10, 2017: Urology
https://www.readbyqxmd.com/read/28399576/local-tumor-control-and-dna-pk-activity-of-peripheral-blood-lymphocytes-in-prostate-cancer-patients-receiving-radiotherapy
#16
Masanori Someya, Tomokazu Hasegawa, Masakazu Hori, Yoshihisa Matsumoto, Kensei Nakata, Naoya Masumori, Koh-Ichi Sakata
Repair of DNA damage is critical for genomic stability, and DNA-dependent protein kinase (DNA-PK) has an important role in repairing double-strand breaks. We examined whether the DNA-PK activity of peripheral blood lymphocytes (PBLs) was related to biochemical (prostate-specific antigen: PSA) relapse and radiation toxicity in prostate cancer patients who have received radiotherapy. A total of 69 patients with localized adenocarcinoma of the prostate participated in this study. Peripheral blood was collected 2 years or later after radiotherapy and centrifuged, then DNA-PK activity was measured by a filter binding assay...
March 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28396184/focal-laser-ablation-of-prostate-cancer-feasibility-of-mri-us-fusion-for-guidance
#17
Shyam Natarajan, Tonye A Jones, Alan M Priester, Rory Geoghegan, Patricia Lieu, Merdie Delfin, Ely Felker, Daniel J A Margolis, Anthony Sisk, Allan Pantuck, Warren Grundfest, Leonard S Marks
PURPOSE: Focal laser ablation (FLA) is a potential treatment for some men with prostate cancer (CaP). As currently practiced, FLA is performed by radiologists in a MRI unit (in-bore). We evaluated the safety and feasibility of performing FLA in a urology clinic (out-of-bore), using magnetic resonance imaging-ultrasound (MRI/US) fusion for guidance. MATERIALS AND METHODS: 11 men with intermediate risk CaP were enrolled in this prospective, IRB-approved pilot study...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28395285/characteristics-of-prostate-cancer-by-opportunistic-screening-in-korean-men-with-a-prostate-specific-antigen-level-less-than-4-0-ng-per-milliliter
#18
Hoon Choi, Seok Cho, Jae Hyun Bae, Sang Eun Lee, Sung Kyu Hong, Du Geon Moon, Jun Cheon, Seok-Soo Byun, Jae Young Park
Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. METHODS: A total of 1,680 men with PSA ≤4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. RESULTS: PCa was diagnosed in 331 (19.6%) and 99 of these 331 cancers (14.9%) had a Gleason score of 7 or higher...
April 11, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28395050/gleason-grading-biochemical-failure-and-prostate-cancer-specific-death
#19
Robin T Vollmer
Objectives: To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods: If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-specific death after biochemical failure is symbolized as P(PSD | BF), then the rules of probability provide a way to estimate P(PSD) as P(PSD) = P(PSD | BF) * P(BF) Using this model and data from the literature for P(PSD | BF) and P(BF), I estimate here values of P(PSD) for the five newly described Gleason grade groups...
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28394754/luminal-water-imaging-a-new-mr-imaging-t2-mapping-technique-for-prostate-cancer-diagnosis
#20
Shirin Sabouri, Silvia D Chang, Richard Savdie, Jing Zhang, Edward C Jones, S Larry Goldenberg, Peter C Black, Piotr Kozlowski
Purpose To assess the feasibility of luminal water imaging, a quantitative T2-based magnetic resonance (MR) imaging technique, for the detection and grading of prostate cancer (PCa). Materials and Methods Eighteen patients with biopsy-proven PCa provided informed consent to be included in this institutional human ethics board-approved prospective study between January 2015 and January 2016. Patients underwent 3.0-T MR imaging shortly before radical prostatectomy. T2 distributions were generated with a regularized non-negative least squares algorithm from multiecho spin-echo MR imaging data...
April 10, 2017: Radiology
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