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https://www.readbyqxmd.com/read/28654336/focal-therapy-for-prostate-cancer-with-in-bore-mr-guided-focused-ultrasound-two-year-follow-up-of-a-phase-i-trial-complications-and-functional-outcomes
#1
Kae Jack Tay, Christopher W S Cheng, Weber K O Lau, James Khoo, Choon Hua Thng, Jin Wei Kwek
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials and Methods Ethics approval was obtained from the centralized institutional review board for this prospective single-arm study, and patients provided informed consent. Patients with untreated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February 2013...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28653675/periprostatic-adipose-inflammation-is-associated-with-high-grade-prostate-cancer
#2
A Gucalp, N M Iyengar, X K Zhou, D D Giri, D J Falcone, H Wang, S Williams, M D Krasne, I Yaghnam, B Kunzel, P G Morris, L W Jones, M Pollak, V P Laudone, C A Hudis, H I Scher, P T Scardino, J A Eastham, A J Dannenberg
BACKGROUND: Obesity, a cause of subclinical inflammation, is associated with increased risk of high-grade prostate cancer (PC) and poor outcomes. Whether inflammation occurs in periprostatic white adipose tissue (WAT), and contributes to the negative impact of obesity on PC aggressiveness, is unknown. METHODS: In a single-center, cross-sectional design, men with newly diagnosed PC undergoing radical prostatectomy were eligible for study participation. The primary objective was to examine the prevalence of periprostatic WAT inflammation defined by the presence of crown-like structures (CLS-P) as detected by CD68 immunohistochemistry...
June 27, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28652121/high-intensity-focused-ultrasound-for-radio-recurrent-prostate-cancer-a-north-american-clinical-trial
#3
Tonye A Jones, Joseph Chin, David Mcleod, Jack Barkin, Allan Pantuck, Leonard S Marks
PURPOSE: To determine the safety and efficacy of whole-gland HIFU in men with radio-recurrent prostate cancer (CaP). MATERIALS AND METHODS: 100 men with clinically localized recurrence of CaP at least 2 years after EBRT received whole-gland HIFU in an open-label trial (2009 to 2012). Treatments were performed at 16 sites in the U.S. (14) and Canada (2). Primary endpoint was a combination of both PSA nadir ≤0.5 ng/ml and negative biopsy at 12 months. Validated questionnaires were used to monitor changes in urinary and sexual function...
June 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28651567/benefits-and-harms-of-prostate-cancer-screening-predictions-of-the-oncotyrol-prostate-cancer-outcome-and-policy-model
#4
Nikolai Mühlberger, Kristijan Boskovic, Murray D Krahn, Karen E Bremner, Willi Oberaigner, Helmut Klocker, Wolfgang Horninger, Gaby Sroczynski, Uwe Siebert
BACKGROUND: A recent recalibration of the ONCOTYROL Prostate Cancer Outcome and Policy (PCOP) Model, assuming that latent prostate cancer (PCa) detectable at autopsy might be detectable by screening as well, resulted in considerable worsening of the benefit-harm balance of screening. In this study, we used the recalibrated model to assess the effects of familial risk, quality of life (QoL) preferences, age, and active surveillance. METHODS: Men with average and elevated familial PCa risk were simulated in separate models, differing in familial risk parameters...
June 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28651247/a-prospective-comparison-of-selective-multiparametric-magnetic-resonance-imaging-fusion-targeted-and-systematic-transrectal-ultrasound-guided-biopsies-for-detecting-prostate-cancer-in-men-undergoing-repeated-biopsies
#5
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
INTRODUCTION: The aim of the study was to compare the prostate cancer (PCa) detection rate of systematic transrectal ultrasound-guided biopsies (TRUS-bx) and multiparametric-MRI targeted biopsies (mp-MRI-bx) in a repeat biopsy setting and evaluate the clinical significance following an "MRI-targeted-only" approach. MATERIALS AND METHODS: Patients with prior negative biopsies underwent prostatic multiparametric-MRI that was scored using the Prostate Imaging Reporting and Data System (PI-RADS) classification...
June 27, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28647216/characteristics-of-prostate-cancer-found-at-fifth-screening-in-the-european-randomized-study-of-screening-for-prostate-cancer-rotterdam-can-we-selectively-detect-high-grade-prostate-cancer-with-upfront-multivariable-risk-stratification-and-magnetic-resonance
#6
Arnout R Alberts, Ivo G Schoots, Leonard P Bokhorst, Frank-Jan H Drost, Geert J van Leenders, Gabriel P Krestin, Roy S Dwarkasing, Jelle O Barentsz, Fritz H Schröder, Chris H Bangma, Monique J Roobol
BACKGROUND: The harm of screening (unnecessary biopsies and overdiagnosis) generally outweighs the benefit of reducing prostate cancer (PCa) mortality in men aged ≥70 yr. Patient selection for biopsy using risk stratification and magnetic resonance imaging (MRI) may improve this benefit-to-harm ratio. OBJECTIVE: To assess the potential of a risk-based strategy including MRI to selectively identify men aged ≥70 yr with high-grade PCa. DESIGN, SETTING, AND PARTICIPANTS: Three hundred and thirty-seven men with prostate-specific antigen ≥3...
June 21, 2017: European Urology
https://www.readbyqxmd.com/read/28638800/prostatic-adenocarcinoma-oncocytic-variant-case-report-and-literature-review
#7
Matthew M Klairmont, Nadeem Zafar
The oncocytic variant of prostatic adenocarcinoma is exceptionally rare with only 4 cases reported in the English literature. Little is known about the clinical behavior of this variant of prostatic adenocarcinoma, because of the exceptionally low number of reported cases. The 2016 World Health Organization Classification of Tumors of Prostate does not recognize the oncocytic variant, again likely related to the exceptional paucity of reported cases. Here, we report the fifth case of the oncocytic variant of acinar type prostatic adenocarcinoma in an asymptomatic 64-year-old Caucasian American male with elevated serum prostate specific antigen (7...
June 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28630592/the-role-of-different-pi-rads-versions-in-prostate-multiparametric-magnetic-resonance-tomography-assessment
#8
Paulius Aliukonis, Tadas Letauta, Rūta Briedienė, Ieva Naruševičiūtė, Simona Letautienė
Background. Standardised Prostate Imaging Reporting and Data System (PI-RADS) guidelines for the assessment of prostate alterations were designed for the assessment of prostate pathology. Published by the ESUR in 2012, PI-RADS v1 was based on the total score of different MRI sequences with subsequent calculation. PI-RADS v2 was published by the American College of Radiology in 2015 and featured different assessment criteria for prostate peripheral and transitory zones. Aim. To assess the correlations of PI-RADS v1 and PI-RADS v2 with Gleason score values and to define their predictive values of the diagnosis of prostate cancer...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28625591/prognostic-significance-of-a-negative-confirmatory-biopsy-on-reclassification-among-men-on-active-surveillance
#9
Vishnu Ganesan, Charles Dai, Yaw A Nyame, Daniel J Greene, Nima Almassi, Daniel Hettel, Joseph Zabell, Hans Arora, Samuel Haywood, Alice Crane, Chad Reichard, Anna Zampini, Ahmed Elshafei, Robert J Stein, Khaled Fareed, J Stephen Jones, Michael Gong, Andrew J Stephenson, Eric A Klein, Ryan K Berglund
OBJECTIVE: To examine the association between absence of disease on confirmatory biopsy and risk of pathologic reclassification in men on active surveillance (AS). METHODS: Men with grade groups 1 and 2 disease on AS between 2002 and 2015 were identified who received a confirmatory biopsy within 1 year of diagnosis and ≥3 biopsies overall. The primary outcomes were pathologic reclassification by grade (any increase in primary Gleason pattern or Gleason score) or volume (>33% of sampled cores involved or increase in the number of cores with >50% involvement)...
June 15, 2017: Urology
https://www.readbyqxmd.com/read/28618395/erg-overexpression-plus-slc45a3-prostein-and-pten-expression-loss-strong-association-of-the-triple-hit-phenotype-with-an-aggressive-pathway-of-prostate-cancer-progression
#10
Silvia Hernández-Llodrà, Nuria Juanpere, Silvia de Muga, Marta Lorenzo, Joan Gil, Alba Font-Tello, Laia Agell, Raquel Albero-González, Laura Segalés, José Merino, Laia Serrano, Lluís Fumadó, Lluís Cecchini, Josep Lloreta Trull
TMPRSS2 and SLC45A3 rearrangements may coexist in the same tumor. ERG rearrangements and PTEN loss are concomitant events in prostate cancer (PrCa), and can cooperate in progression. We have reported that mRNA expression of TMPRSS2-ERG and SLC45A3-ERG rearrangements plus PTEN loss define an aggressive tumor subset. The aim of this study has been to validate these results by immunohistochemistry in a large cohort of tumors. ERG, SLC45A3 and PTEN immunostaining and their association with pathological features and PSA progression-free survival were analyzed in 220 PrCa (PSMAR-Biobank, Barcelona, Spain)...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614086/the-present-and-future-of-prostate-cancer-histopathology
#11
Jesse K McKenney
PURPOSE OF REVIEW: The present review describes recent changes in the histologic grading of prostatic adenocarcinoma and emerging data suggesting areas for further grade optimization. RECENT FINDINGS: The grading of prostatic adenocarcinoma has evolved over time, and optimization for active surveillance management has been one major driving force. Recent changes include adoption of the Grade Group system, which stratifies patients into one of five prognostic groups...
June 12, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28607597/psa-and-prostate-health-index-based-prostate-cancer-screening-in-a-hereditary-migration-complicated-population-implications-in-precision-diagnosis
#12
Mariyam Akizhanova, Elzira E Iskakova, Valdemir Kim, Xiao Wang, Roman Kogay, Aiym Turebayeva, Qinglei Sun, Ting Zheng, Shenghui Wu, Lixia Miao, Yingqiu Xie
Precision diagnosis requires specific markers for differential ethnic populations. Prostate-Specific Antigen (PSA) level (threshold of 4ng/ml) has been widely used to screen prostate cancer and as reference of pro-biopsy but false diagnosis frequently occurs. Prostate health Index (PHI) is a new diagnosis marker which combines PSA, free PSA and p2PSA4. Overall the PCa screening database is lacking in Kazakhstani patients. We analyzed the PSA levels and Gleason scores of 222 biopsies collected in 2015 in Almaty area, Kazakhstan approved by institutional ethics board...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28606276/-the-comparation-of-fusion-targeting-biopsy-and-systematic-biopsy-in-the-clinical-diagnosis-of-prostate-cancer-a-meta-analysis
#13
L J Zhang, B Wu, Z L Zha, H Zhao, W Yang, X H Chen, B Jiang, Y F Jiang, J L Yin
Objective: To systematically compare the differences in the detection rate of prostate cancer with fusion targeting biopsy and systemic biopsy. Methods: A computer-based search of PubMed, Medline, China Biomedical Literature Database and Wanfang database (from the beginning of establishment of library to October 2016) on the detection rate of prostate cancer by fusion targeting biopsy and systemic biopsy was performed manually.The inclusion and exclusion criteria were formulated by 2 reviewers, and the data were extracted and evaluated respectively...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28602051/yes-associated-protein-expression-is-correlated-to-the-differentiation-of-prostate-adenocarcinoma
#14
Myung-Giun Noh, Sung Sun Kim, Eu Chang Hwang, Dong Deuk Kwon, Chan Choi
Background: Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control pathway that regulates cell proliferation and stem cell functions. Abnormal regulation of YAP was reported in human cancers including liver, lung, breast, skin, colon, and ovarian cancer. However, the function of YAP is not known in prostate adenocarcinoma. The purpose of this study was to investigate the role of YAP in tumorigenesis, differentiation of the carcinoma, and prognosis of prostate adenocarcinoma...
June 9, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28595934/secular-trends-in-prostate-biopsy-criteria-and-outcomes-the-dartmouth-experience
#15
Lael Reinstatler, Cody Rissman, John D Seigne, Elias S Hyams
OBJECTIVE: To evaluate trends in prostate biopsy and prostate cancer diagnosis at a center with conservative baseline screening practices in the pre- and post-2012 era. More restrictive prostate-specific antigen (PSA) screening guidelines have led to lower rates of screening, biopsy and diagnosis of prostate cancer post-2012. It is not clear, however, how regions with low baseline screening rates (e.g. the Lebanon, NH hospital referral region centered on Dartmouth-Hitchcock Medical Center, with the lowest rate of screening among Medicare patients in 2012) have responded these guidelines...
June 5, 2017: Urology
https://www.readbyqxmd.com/read/28595267/cholesterol-uptake-and-regulation-in-high-grade-and-lethal-prostate-cancers
#16
Konrad H Stopsack, Travis A Gerke, Ove Andrén, Swen-Olof Andersson, Edward L Giovannucci, Lorelei A Mucci, Jennifer R Rider
Lethal prostate cancers have higher expression of squalene monooxygenase (SQLE), the second rate-limiting enzyme of cholesterol synthesis. Preclinical studies suggested that aberrant cholesterol regulators, receptors, and transporters contribute to cholesterol accumulation uniformly. We assessed their association with features of aggressive cancers. In the prospective prostate cancer cohorts within the Health Professional Follow-up Study, the Physicians' Health Study, and the Swedish Watchful Waiting Study, tumor mRNA expression profiling was performed...
June 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28592125/correlation-of-gankyrin-oncoprotein-overexpression-with-histopathological-grade-in-prostate-cancer
#17
M M Riahi, N S Sistani, P Zamani, K Abnous, K Jamialahmadi
Prostate cancer is the second most commonly diagnosed cancer among men worldwide. Identifying new prognostic and predictive biomarkers will help stratification of prostate cancer patients for a better treatment. Gankyrin is a novel oncoprotein which regulates cell cycle and protein degradation. Gankyrin overexpression correlated with the malignant phenotypes and promotes the tumorigenicity and metastasis in many cancers. However there are not any reports on the role of Gankyrin in prostate cancer. Therefore, this study was designed to investigate the expression of Gankyrin in prostate cancer and analyze its correlation with some clinicopathological characteristics...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28591934/long-term-adverse-effects-after-retropubic-and-robot-assisted-radical-prostatectomy-nationwide-population-based-study
#18
Jón Örn Fridriksson, Yasin Folkvaljon, Karl-Johan Lundström, David Robinson, Stefan Carlsson, Pär Stattin
BACKGROUND AND OBJECTIVES: Surgery for prostate cancer is associated with adverse effects. We studied long-term risk of adverse effects after retropubic (RRP) and robot-assisted radical prostatectomy (RARP). METHODS: In the National Prostate Cancer Register of Sweden, men who had undergone radical prostatectomy (RP) between 2004 and 2014 were identified. Diagnoses and procedures indicating adverse postoperative effects were retrieved from the National Patient Register...
June 7, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28590015/mucinous-adenocarcinoma-of-prostate-and-prostatic-adenocarcinoma-with-mucinous-components-a-clinicopathological-analysis-of-143-cases
#19
Hemamali Samaratunga, Brett Delahunt, John R Srigley, John Yaxley, Shulammite Johannsen, Geoffrey Coughlin, Troy Gianduzzo, Boon Kua, Imogen Patterson, John N Nacey, Lars Egevad
The clinical significance of mucinous prostatic adenocarcinoma remains uncertain. From 6440 cases of prostatic adenocarcinoma treated by radical prostatectomy and reported by Aquesta Uropathology from 2009 to 2014, mucinous components of 5-100% were found in 143 (2.2%). The mean age was 61.4 years, mean preoperative serum was PSA 7.8 ng/mL and clinical stage category was cT1 in 81% and cT2 in 19% of cases. Cases were graded using the 2014 International Society of Urological Pathology recommendation of grading the underlying architecture and Gleason scores were 3+4 in 13...
June 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28585137/risk-factors-of-perioperative-complications-in-patients-undergoing-radical-retropubic-prostatectomy-a-ten-year-experience
#20
Xiao-Jun Liu, Liang Liu, Kun Chang, Ding-Wei Ye, Yong-Fa Zheng, Xu-Dong Yao
Radical retropubic prostatectomy (RRP) has been one of the most effective treatments for prostate cancer. This study is designed to identify the related predictive risk factors for complications in patients following RRP. Between 2000 and 2012 in Department of Urology, Fudan University Shanghai Cancer Center, 421 cases undergoing RRP for localized prostate cancer by one surgeon were included in this retrospective analysis. We reviewed various risk factors that were correlated with perioperative complications, including patient characteristics [age, body mass index (BMI), co-morbidities], clinical findings (preoperative PSA level, Gleason score, clinical stage, pathological grade), and surgeon's own clinical practice...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
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