keyword
MENU ▼
Read by QxMD icon Read
search

gleason grades

keyword
https://www.readbyqxmd.com/read/29223469/oncological-and-functional-outcomes-of-elderly-men-treated-with-hifu-vs-minimally-invasive-radical-prostatectomy-a-propensity-score-analysis
#1
Paolo Capogrosso, Eric Barret, Rafael Sanchez-Salas, Igor Nunes-Silva, François Rozet, Marc Galiano, Eugenio Ventimiglia, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Xavier Cathelineau
AIM: To assess outcomes of whole gland high-intensity focused ultrasound (HIFU) as compared with minimally-invasive radical prostatectomy (MIRP) in elderly patients. MATERIALS & METHODS: Patients aged ≥70 years with, cT1-cT2 disease, biopsy Gleason score (GS) 3 + 3 or 3 + 4 and preoperative PSA ≤10 ng/mL were submitted to either whole-gland HIFU or MIRP. Propensity-score matching analysis was performed to ensure the baseline equivalence of groups. Follow-up visits were routinely performed assessing PSA and urinary function according to the International Continence Score (ICS) and the International Prostatic Symptoms Score (IPSS) questionnaires...
December 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#2
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29220213/clinical-application-of-biparametric-mri-texture-analysis-for-detection-and-evaluation-of-high-grade-prostate-cancer-in-zone-specific-regions
#3
Xiang-Ke Niu, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng, Xin Li
OBJECTIVE: The purpose of this study was to investigate the performance of biparametric MRI texture analysis (TA) in detecting and evaluating high-grade prostate cancer in zone-specific regions. MATERIALS AND METHODS: A retrospective study included 184 consecutively registered biopsy-naive patients in whom prostate cancer was suspected who were undergoing multiparametric prostate MRI. MR images were scored and evaluated by two readers using the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and biparametric MRI TA in separate sessions...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29212392/multi-parametric-magnetic-resonance-imaging-monitoring-patients-in-active-surveillance-for-prostate-cancer-a-prospective-cohort-study
#4
Maria Carlsen Elkjær, Morten Heebøll Andersen, Søren Høyer, Bodil Ginnerup Pedersen, Michael Borre
OBJECTIVES: To evaluate the use of multi-parametric magnetic resonance imaging (mpMRI) and mpMRI guided biopsies (MRGB) for monitoring an active surveillance (AS) prostate cancer cohort. MATERIALS AND METHODS: One year after initial diagnostic TRUS guided biopsy (TRUS-bx), baseline mpMRI, and enrolment in an AS program patients underwent a one year follow-up comprising the usual TRUS-bx and an mpMRI. Prostate MRI lesions were scored on the five-point PIRADS scale version 2...
December 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29211393/the-impact-of-metformin-use-on-the-risk-of-prostate-cancer-after-prostate-biopsy-in-patients-with-high-grade-intraepithelial-neoplasia
#5
Lucio Dell'Atti, Andrea B Galosi
PURPOSE: We report our experience on metformin use in diabetic patients and its impact on prostate cancer (PCa) after a high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosis. MATERIALS AND METHODS: We retrospectively analyzed 551 patients with a diagnosis of HGPIN without PCa in a first prostate biopsy. The cohort of the study consisted of 456 nondiabetic subjects, and 95 diabetic patients. Among the patients with diabetes 44 were treated with metformin, and 51 with other antidiabetic drugs...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29211355/tumor-marker-%C3%AE-fetoprotein-receptor-does-not-discriminate-between-benign-prostatic-disease-and-prostate-cancer
#6
Tomaž Smrkolj, Borut Gubina, Jure Bizjak, Kristina Kumer, Teja Fabjan, Joško Osredkar
BACKGROUND: The α-fetoprotein receptor (RECAF) is a proposed novel tumor marker for detecting several different types of tumors, including prostate cancer (PCa). OBJECTIVES: The aim of the study was to evaluate RECAF in discriminating benign prostatic conditions from PCa and to compare it with prostate-specific antigen (PSA). MATERIAL AND METHODS: A total of 64 patients with elevated serum PSA levels and/or abnormal digital rectal examination of the prostate referred to a tertiary center for transrectal ultrasound (TRUS) biopsy of the prostate were prospectively enrolled in the study from January 2009 to April 2010...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29207031/prl%C3%A2-3-increases-the-aggressive-phenotype-of-prostate-cancer-cells-in%C3%A2-vitro-and-its-expression-correlates-with-high-grade-prostate-tumors-in-patients
#7
Donna R Edwards, Krzysztof Moroz, Haitao Zhang, David Mulholland, Asim B Abdel-Mageed, Debasis Mondal
The increased expression of phosphatase of regenerating liver-3 (PRL‑3) has been shown to be associated with the aggressive and metastatic phenotype of different solid tumors. However, it is not known whether PRL‑3 plays a similar role in the progression of prostate cancer (PCa). In this study, immunoblot analysis of androgen receptor (AR)-positive PCa lines (LNCaP and LNCaP‑SF) revealed the constitutive cytoplasmic expression of PRL‑3, and stimulation with R1881 (AR agonist) rapidly increased the nuclear translocation of PRL‑3...
November 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#8
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29202848/downregulation-of-mir-141-3p-promotes-bone-metastasis-via-activating-nf-%C3%AE%C2%BAb-signaling-in-prostate-cancer
#9
Shuai Huang, Qingde Wa, Jincheng Pan, Xinsheng Peng, Dong Ren, Yan Huang, Xiao Chen, Yubo Tang
BACKGROUND: Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved in the progression and metastasis of several human cancer types. However, the clinical significance and biological roles of miR-141-3p in bone metastasis of PCa are still unclear. METHODS: miR-141-3p expression was examined in 89 non-bone metastatic and 52 bone metastatic PCa tissues by real-time PCR...
December 4, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29199015/contemporary-prognostic-indicators-for-prostate-cancer-incorporating-international-society-of-urological-pathology-recommendations
#10
REVIEW
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
November 30, 2017: Pathology
https://www.readbyqxmd.com/read/29196529/no-association-of-waist-circumference-and-prostate-cancer-in-the-cancer-prevention-study-ii-nutrition-cohort
#11
Victoria L Stevens, Eric J Jacobs, Maret L Maliniak, Alpa V Patel, Susan M Gapstur
Background: The relationship between excess body weight and prostate cancer risk is unclear. However, some evidence suggests that waist circumference, which provides a measure of central adiposity, may be positively associated with more advanced stages or grades of prostate cancer.Methods: The association between waist circumference and prostate cancer was investigated among 46,094 men enrolled in the Cancer Prevention Study II Nutrition Cohort, of whom 5,711 were diagnosed with this cancer between 1997 and 2013...
December 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29196209/pathologic-outcomes-of-gleason-6-favorable-intermediate-risk-prostate-cancer-treated-with-radical-prostatectomy-implications-for-active-surveillance
#12
David D Yang, Brandon A Mahal, Vinayak Muralidhar, Marie E Vastola, Ninjin Boldbaatar, Shelby A Labe, Michelle D Nezolosky, Peter F Orio, Martin T King, Neil E Martin, Kent W Mouw, Quoc-Dien Trinh, Paul L Nguyen
BACKGROUND: The safety of active surveillance (AS) for Gleason 6 favorable intermediate-risk (FIR) prostate cancer is unknown. To provide guidance, we examined the incidence and predictors of upgrading or upstaging for Gleason 6 FIR patients treated with radical prostatectomy. PATIENTS AND METHODS: We identified 2807 men in the National Cancer Database diagnosed from 2010 to 2012 with Gleason 6 FIR disease (<50% positive biopsy cores [PBC] with either prostate-specific antigen [PSA] of 10-20 ng/mL or cT2b-T2c disease) treated with radical prostatectomy...
November 9, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29194902/metastatic-prostate-cancer-incidence-in-australia-after-amendment-to-prostate-specific-antigen-screening-guidelines
#13
Sabin Smith, Philippe Wolanski
BACKGROUND: To compare the incidence of newly diagnosed metastatic prostate cancer at an Australian facility pre- and post-publication of the United States Preventive Services Task Force (USPSTF) guidelines and subsequent amendment of the Royal Australian College of General Practitioners Preventive Activities in General Practice guidelines. METHODS: A retrospective analysis was undertaken by patients with newly diagnosed prostate cancer following transrectal ultrasound-guided biopsy between 2009 and 2014...
November 30, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29190707/hypofractionated-stereotactic-boost-in-intermediate-risk-prostate-carcinoma-preliminary-results-of-a-multicenter-phase-ii-trial-ckno-pro
#14
David Pasquier, Philippe Nickers, Didier Peiffert, Philippe Maingon, Pascal Pommier, Thomas Lacornerie, Geoffrey Martinage, Emmanuelle Tresch, Eric Lartigau
PURPOSE: Dose escalation may improve curability in intermediate-risk prostate carcinoma. A multicenter national program was developed to assess toxicity and tumor response with hypofractionated stereotactic boost after conventional radiotherapy in intermediate-risk prostate cancer. METHODS AND MATERIAL: Between August 2010 and April 2013, 76 patients with intermediated-risk prostate carcinoma were included in the study. A first course delivered 46 Gy by IMRT (68...
2017: PloS One
https://www.readbyqxmd.com/read/29188201/significant-prognostic-difference-between-grade-group-4-and-5-in-the-2014-international-society-of-urological-pathology-grading-system-for-high-grade-prostate-cancer-with-bone-metastasis
#15
Yasutaka Yamada, Shinichi Sakamoto, Jun Shimazaki, Masahiro Sugiura, Yoshiyasu Amiya, Makoto Sasaki, Takayuki Shima, Akira Komiya, Noriyuki Suzuki, Koichiro Akakura, Tomohiko Ichikawa, Hiroomi Nakatsu
Background: To investigate prognostic difference between Gleason Score (GS) 8 and 9-10, as the 2014 International Society of Urological Pathology Gleason Grading Systems proposed, in patients with prostate cancer (PCa) with bone metastasis. Materials and methods: We retrospectively reviewed data on 106 patients with GS 8-10 between 2006 and 2016. All patients received androgen deprivation therapy immediately. We validated biochemical recurrence, PCa-specific survival, and overall survival, and analyzed the predictive value for overall survival...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29187874/albumin-and-fibrinogen-combined-prognostic-grade-predicts-prognosis-of-patients-with-prostate-cancer
#16
Yanqing Wang, Wei Chen, Chuanyi Hu, Xiaofei Wen, Jiahua Pan, Fan Xu, Yinjie Zhu, Xiaoguang Shao, Xun Shangguan, Liancheng Fan, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue
Background: The nutritional status and systemic inflammation are thought to be associated with outcome in multiple types of cancer. The objective of this study was to determine the prognostic value of pretreatment albumin and fibrinogen combined prognostic grade (AFPG) in prostate cancer (PCa). Methods: 462 prostate cancer patients who had undergone androgen deprivation therapy (ADT) as first-line therapy at four cencters were retrospectively analyzed. The serum albumin levels and plasma fibrinogen levels were measured at the time of diagnosis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29187467/diagnostic-performance-of-multiparametric-magnetic-resonance-imaging-and-fusion-targeted-biopsy-to-detect-significant-prostate-cancer
#17
Manuela A Hoffmann, Kasra Taymoorian, Christian Ruf, Arnd Gerhards, Karlheinz Leyendecker, Thomas Stein, Frank M Jakobs, Mathias Schreckenberger
BACKGROUND/AIM: Multiparametric magnetic resonance imaging combined with ultrasound-fusion-targeted biopsy of the prostate intends to increase diagnostic precision, which has to be clarified. PATIENTS AND METHODS: We performed multiparametric magnetic resonance imaging followed by ultrasound-fusion-guided perineal biopsy in 99 male patients with elevated prostate-specific-antigen and previous negative standard biopsy-procedures. RESULTS: In 33/99 patients (33%) no malignancy could be confirmed by histopathology...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29180249/tumor-necrosis-in-radical-prostatectomies-with-high-grade-prostate-cancer-is-associated-with-multiple-poor-prognostic-features-and-a-high-prevalence-of-residual-disease
#18
Andres M Acosta, Mohamed R H Al Rasheed, Garth H Rauscher, Erica Vormittag, Khin Su Mon, Asma Sharif, Andre Kajdacsy-Balla, Gayatry Mohapatra
The Gleason Grading System and the recently defined Grade Groups are strong, well-established predictors of outcome in prostate cancer. Each Gleason score, however, is the result of a sum of categories (Gleason Patterns or GP) that are intrinsically heterogeneous, as each individual pattern encompasses several tumor morphologies. While the prognostic value of specific morphologic components of GP4 has recently been demonstrated, the significance of the different patterns of GP5 is largely unknown. We reviewed 344 consecutive prostatectomies performed at the Hospital of the University of Illinois at Chicago between 2011 and 2016, and selected 56 cases with primary or secondary GP5 with archival material available for review...
November 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29165567/impact-of-the-pathologist-on-prostate-biopsy-diagnosis-and-immunohistochemical-stain-usage-within-a-single-institution
#19
Mit D Shah, Anil V Parwani, Debra L Zynger
Objectives: To determine whether pathologists in a tertiary care institution vary in diagnosis and immunohistochemical stain usage in prostate biopsy specimens. Methods: Men who underwent prostate needle biopsies between 2008 and 2013 were included. Results: In total, 1,777 prostate biopsy specimens diagnosed by nine pathologists showed variation in diagnostic reporting (atypical small acinar proliferation, 2.0%-8.0%; high-grade prostatic intraepithelial neoplasia, 2...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29163712/combinations-of-elevated-tissue-mirna-17-92-cluster-expression-and-serum-prostate-specific-antigen-as-potential-diagnostic-biomarkers-for-prostate-cancer
#20
Sujuan Feng, Xiaosong Qian, Han Li, Xiaodong Zhang
The aim of the present study was to investigate the effectiveness of the miR-17-92 cluster as a disease progression marker in prostate cancer (PCa). Reverse transcription-quantitative polymerase chain reaction analysis was used to detect the microRNA (miR)-17-92 cluster expression levels in tissues from patients with PCa or benign prostatic hyperplasia (BPH), in addition to in PCa and BPH cell lines. Spearman correlation was used for comparison and estimation of correlations between miRNA expression levels and clinicopathological characteristics such as the Gleason score and prostate-specific antigen (PSA)...
December 2017: Oncology Letters
keyword
keyword
98250
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"