keyword
MENU ▼
Read by QxMD icon Read
search

gleason grades

keyword
https://www.readbyqxmd.com/read/29034282/differentiation-of-prostate-cancer-lesions-in-the-transition-zone-by-diffusion-weighted-mri
#1
Jie Bao, Ximing Wang, Chunhong Hu, Jianquan Hou, Fenglin Dong, Lingchuan Guo
OBJECTIVE: To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS: Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm(2)) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analyses were performed by outlining entire-tumor regions of interest (ROIs)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29034236/prognostic-value-of-the-new-prostate-cancer-international-society-of-urological-pathology-grade-groups
#2
Anne Offermann, Silke Hohensteiner, Christiane Kuempers, Julika Ribbat-Idel, Felix Schneider, Finn Becker, Marie Christine Hupe, Stefan Duensing, Axel S Merseburger, Jutta Kirfel, Markus Reischl, Verena Lubczyk, Rainer Kuefer, Sven Perner
Gleason grading is the best independent predictor for prostate cancer (PCa) progression. Recently, a new PCa grading system has been introduced by the International Society of Urological Pathology (ISUP) and is recommended by the World Health Organization (WHO). Following studies observed more accurate and simplified grade stratification of the new system. Aim of this study was to compare the prognostic value of the new grade groups compared to the former Gleason Grading and to determine whether re-definition of Gleason Pattern 4 might reduce upgrading from prostate biopsy to radical prostatectomy (RP) specimen...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29034221/atypical-small-acinar-proliferation-and-two-or-more-cores-of-high-grade-intraepithelial-neoplasia-on-a-previous-prostate-biopsy-are-significant-predictors-of-cancer-during-a-transperineal-template-guided-saturation-biopsy-aimed-at-sampling-one-core-for-each
#3
Yasushi Nakai, Nobumichi Tanaka, Makito Miyake, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The objective of this study was to evaluate whether high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) predict prostate cancer (PCa) during repeat transperineal template saturation biopsy with a high number of cores per prostate volume in patients with persistent clinical suspicion of PCa who underwent at least one previous negative transrectal ultrasound (TRUS)-guided biopsy. METHODS: We retrospectively evaluated 135 consecutive patients with persistent clinical suspicion of PCa, despite a set of negative TRUS-guided biopsies and increasing prostate-specific antigen levels; abnormal findings on digital rectal examination, TRUS, or magnetic resonance imaging; previous biopsy showing HGPIN; and previous biopsy showing atypical glands...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29032296/most-gleason-8-biopsies-are-downgraded-on-prostatectomy-does-4-4-7
#4
Ted Gansler, Stacey Fedewa, Robert Qi, Chun Chieh Lin, Ahmedin Jemal, Judd W Moul
PURPOSE: Non-representative biopsy sampling of prostate cancers with a biopsy Gleason score of 8 can adversely influence decisions regarding androgen deprivation among men receiving primary radiation therapy. The frequency of and factors associated with downgrading of Gleason 8 biopsies at prostatectomy are not well known. MATERIALS AND METHODS: Records from the National Cancer Database (a hospital-based registry in the United States) of 72,556 men with prostate cancer diagnosed 2010-2013, including 5,474 with Gleason 8 biopsies and no other high progression-risk criteria (per National Comprehensive Cancer Network guidelines)...
October 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29029032/foxa1-expression-is-a-strong-independent-predictor-of-early-psa-recurrence-in-erg-negative-prostate-cancers-treated-by-radical-prostatectomy
#5
Maria Christina Tsourlakis, Agapi Eleftheriadou, Annegret Stender, Philipp Weigand, Katharina Grupp, Claudia Hube-Magg, Martina Kluth, Cornelia Schroeder, Stefan Steurer, Andrea Hinsch, Andreas Luebke, Alexander Angerer, Corinna Wittmer, Emily Friedrich, Cosima Göbel, Franziska Büscheck, Hans Heinzer, Markus Graefen, Ronald Simon, Guido Sauter, Waldemar Wilczak, Sarah Minner, Thorsten Schlomm, Frank Jacobsen
FOXA1 is a transcription factor involved in androgen signaling with relevance for lineage specific gene expression of the prostate. The expression was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancer specimens. Results were compared to tumor phenotype, biochemical recurrence, androgen receptor expression, ERG status and other recurrent genomic alterations. FOXA1 expression was detectable in 97.6% of 8,227 interpretable cancers and considered strong in 28.5%, moderate in 46...
September 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29024425/multicentre-evaluation-of-magnetic-resonance-imaging-supported-transperineal-prostate-biopsy-in-biopsy-na%C3%A3-ve-men-with-suspicion-of-prostate-cancer
#6
N L Hansen, T Barrett, C Kesch, L Pepdjonovic, D Bonekamp, R O'Sullivan, F Distler, A Warren, C Samel, B Hadaschik, J Grummet, C Kastner
OBJECTIVES: To analyse the detection rates of primary MRI-fusion transperineal prostate biopsy using combined targeted and systematic core distribution in three tertiary referral centres. PATIENTS AND METHODS: Multicentre, prospective outcome study of 807 consecutive biopsy-naïve patients having undergone MRI-guided transperineal prostate biopsy as the first diagnostic intervention between 10/2012 and 05/2016. MRI was reported following PI-RADS criteria. 236 patients had 18-24 systematic transperineal biopsies only, and 571 patients underwent additional targeted biopsies either by MRI-fusion or cognitive targeting if PI-RADS ≥3 lesions were present...
October 11, 2017: BJU International
https://www.readbyqxmd.com/read/29023572/computer-aided-detection-in-prostate-cancer-diagnostics-a-promising-alternative-to-biopsy-a-retrospective-study-from-104-lesions-with-histological-ground-truth
#7
Anika Thon, Ulf Teichgräber, Cornelia Tennstedt-Schenk, Stathis Hadjidemetriou, Sven Winzler, Ansgar Malich, Ismini Papageorgiou
BACKGROUND: Prostate cancer (PCa) diagnosis by means of multiparametric magnetic resonance imaging (mpMRI) is a current challenge for the development of computer-aided detection (CAD) tools. An innovative CAD-software (Watson Elementary™) was proposed to achieve high sensitivity and specificity, as well as to allege a correlate to Gleason grade. AIM/OBJECTIVE: To assess the performance of Watson Elementary™ in automated PCa diagnosis in our hospital´s database of MRI-guided prostate biopsies...
2017: PloS One
https://www.readbyqxmd.com/read/29019329/implications-of-observer-variation-in-gleason-scoring-of-prostate-cancer-on-clinical-management-a-collaborative-audit
#8
A Harbias, E Salmo, A Crump
BACKGROUND: Prostate cancer is the most frequently diagnosed cancer in men. Histological tumour grade is a strong predictor of outcome and helps determine what treatment options are offered. There are numerous studies on Inter-observer agreement/variability on prostate cancer grading. In this study, we were looking to establish if disconcordance between pathologists when grading prostate cancer, could affect treatment options offered to men. METHODS: In Greater Manchester West Cancer Sector, all prostate cancer biopsies undergo a central review by three pathologists with a special interest in urological pathology prior to referral for treatment at specialist centres...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29019021/analysis-of-histological-findings-obtained-combining-us-mp-mri-fusion-guided-biopsies-with-systematic-us-biopsies-mp-mri-role-in-prostate-cancer-detection-and-false-negative
#9
Eliodoro Faiella, Domiziana Santucci, Federico Greco, Giulia Frauenfelder, Viola Giacobbe, Giovanni Muto, Bruno Beomonte Zobel, Rosario Francesco Grasso
AIMS AND OBJECTIVES: To evaluate the diagnostic accuracy of mp-MRI correlating US/mp-MRI fusion-guided biopsy with systematic random US-guided biopsy in prostate cancer diagnosis. MATERIALS AND METHODS: 137 suspected prostatic abnormalities were identified on mp-MRI (1.5T) in 96 patients and classified according to PI-RADS score v2. All target lesions underwent US/mp-MRI fusion biopsy and prostatic sampling was completed by US-guided systematic random 12-core biopsies...
October 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28990727/magnetic-resonance-imaging-of-the-prostate-and-targeted-biopsy-comparison-of-pirads-and-gleason-grading
#10
Matthew Bastian-Jordan
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) of the prostate has become integral in the investigation of suspected prostate cancer. Regions of interest are graded using the PIRADS scoring system, and in our institution, lesions graded as PIRADS 3-5 undergo sampling by MRI-guided biopsy. Limited data currently exists on PIRADS grading and biopsy results. METHODS: Retrospective review of 343 MRI-guided biopsies (MRGB) performed between April 2013 and December 2016 was conducted...
October 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28986510/combined-18-f-fluciclovine-pet-mri-shows-potential-for-detection-and-characterization-of-high-risk-prostate-cancer
#11
Mattijs Elschot, Kirsten M Selnæs, Elise Sandsmark, Brage Krüger-Stokke, Øystein Størkersen, Guro F Giskeødegård, May-Britt Tessem, Siver A Moestue, Helena Bertilsson, Tone F Bathen
The objective of this study is to investigate if quantitative imaging features derived from combined (18)F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for detection and characterization of primary prostate cancer. Methods: Twenty-eight (28) patients diagnosed with high-risk prostate cancer underwent simultaneous (18)F-Fluciclovine PET/MRI before radical prostatectomy. Volumes-of-interest (VOIs) of prostate tumors, benign prostatic hyperplasia (BPH) nodules, prostatitis, and healthy tissue were delineated on T2-weighted images using histology as a reference...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28977109/low-serum-testosterone-is-a-predictor-of-high-grade-disease-in-patients-with-prostate-cancer
#12
George A M Lins de Albuquerque, Giuliano B Guglielmetti, João Arthur B A Barbosa, José Pontes, Arnaldo J C Fazoli, Maurício D Cordeiro, Rafael F Coelho, Paulo Afonso de Carvalho, Fábio P Gallucci, Guilherme P Padovani, Rubens Park, José Cury, Henrique Nonemacher, Miguel Srougi, William C Nahas
OBJECTIVE: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. METHOD: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens...
August 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28975495/evaluation-of-tumor-morphologies-and-association-with-biochemical-recurrence-after-radical-prostatectomy-in-grade-group-5-prostate-cancer
#13
Trevor A Flood, Nicola Schieda, Jordan Sim, Rodney H Breau, Chris Morash, Eric C Belanger, Susan J Robertson
We assessed Gleason pattern 5 (GP5) and other prostatic adenocarcinoma (PCa) morphologies to determine their association with biochemical recurrence (BCR). A search for grade group 5 PCa with radical prostatectomy (RP) yielded 49 patients. RPs were reviewed for %GP5 and morphologies (sheets, single cells, cords, small solid cylinders, solid medium to large nests with rosette-like spaces [SMLNRS], comedonecrosis, cribriform glands, glomerulations, intraductal carcinoma of the prostate [IDC-P], and prostatic ductal adenocarcinoma [PDCa])...
October 3, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28974201/effects-of-increasing-the-psa-cutoff-to-perform-additional-biomarker-tests-before-prostate-biopsy
#14
Tobias Nordström, Jan Adolfsson, Henrik Grönberg, Martin Eklund
BACKGROUND: Multi-step testing might enhance performance of the prostate cancer diagnostic pipeline. Using PSA >1 ng/ml for first-line risk stratification and the Stockholm 3 Model (S3M) blood-test >10% risk of Gleason Score > 7 prostate cancer to inform biopsy decisions has been suggested. We aimed to determine the effects of changing the PSA cutoff to perform reflex testing with S3M and the subsequent S3M cutoff to recommend prostate biopsy while maintaining the sensitivity to detect Gleason Score ≥ 7 prostate cancer...
October 3, 2017: BMC Urology
https://www.readbyqxmd.com/read/28972962/igf-1r-associates-with-adverse-outcomes-after-radical-radiotherapy-for-prostate-cancer
#15
Tamara Aleksic, Clare Verrill, Richard J Bryant, Cheng Han, Andrew Ross Worrall, Laurent Brureau, Stephane Larré, Geoff S Higgins, Fahad Fazal, Ahmad Sabbagh, Syed Haider, Francesca M Buffa, David Cole, Valentine M Macaulay
BACKGROUND: Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We previously reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionising radiation. Here we tested the clinical relevance of these findings. METHODS: We assessed associations between IGF-1R and clinical outcomes by immunohistochemistry in diagnostic biopsies of 136 men treated with 55-70 Gy external beam radiotherapy for prostate cancer, comparing results with publicly available transcriptional data in surgically treated patients...
October 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28972698/prognostic-value-of-urinary-pca3-during-active-surveillance-of-low-risk-prostate-cancer-in-patients-receiving-5%C3%AE-reductase-inhibitors
#16
Vincent Fradet, Paul Toren, Molière Nguile-Makao, Michele Lodde, Jérome Lévesque, Caroline Léger, André Caron, Alain Bergeron, Tal Ben-Zvi, Louis Lacombe, Frédéric Pouliot, Rabi Tiguert, Thierry Dujardin, Yves Fradet
OBJECTIVES: To determine the clinical performance of the urinary PCA3 test to predict the risk of Gleason grade re-classification among men receiving a 5α-reductase inhibitor during active surveillance for prostate cancer. PATIENTS AND METHODS: Patients with low-risk prostate cancer were enrolled in a prospective Phase II study of active surveillance complemented with prescription of a 5ARI. Repeat biopsy was performed within the first year and annually according to physician and patient preference...
October 3, 2017: BJU International
https://www.readbyqxmd.com/read/28961847/intratumoural-evolutionary-landscape-of-high-risk-prostate-cancer-the-progeny-study-of-genomic-and-immune-parameters
#17
M Linch, G Goh, C Hiley, Y Shanmugabavan, N McGranahan, A Rowan, Y N S Wong, H King, A Furness, A Freeman, J Linares, A Akarca, J Herrero, R Rosenthal, N Harder, G Schmidt, G A Wilson, N J Birkbak, R Mitter, S Dentro, P Cathcart, M Arya, E Johnston, R Scott, M Hung, M Emberton, G Attard, Z Szallasi, S Punwani, S A Quezada, T Marafioti, M Gerlinger, H U Ahmed, C Swanton
Background: Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC), but its role in high-risk disease is uncertain. A prospective, single-arm, translational study using targeted multiregion prostate biopsies was carried out to study genomic and T-cell ITH in clinically high-risk PC aiming to identify drivers and potential therapeutic strategies. Patients and methods: Forty-nine men with elevated prostate-specific antigen and multiparametric-magnetic resonance imaging detected PC underwent image-guided multiregion transperineal biopsy...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28961382/characterization-and-stratification-of-prostate-lesions-based-on-comprehensive-multiparametric-mri-using-detailed-whole-mount-histopathology-as-a-reference-standard
#18
Olga Starobinets, Jeffry P Simko, Kyle Kuchinsky, John Kornak, Peter R Carroll, Kirsten L Greene, John Kurhanewicz, Susan M Noworolski
The purpose of this study was to characterize prostate cancer (PCa) based on multiparametric MR (mpMR) measures derived from MRI, diffusion, spectroscopy, and dynamic contrast-enhanced (DCE) MRI, and to validate mpMRI in detecting PCa and predicting PCa aggressiveness by correlating mpMRI findings with whole-mount histopathology. Seventy-eight men with untreated PCa received 3 T mpMR scans prior to radical prostatectomy. Cancerous regions were outlined, graded, and cancer amount estimated on whole-mount histology...
September 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28952300/the-prognostic-factors-of-biochemical-recurrence-free-survival-following-radical-prostatectomy
#19
Virote Chalieopanyarwong, Worapat Attawettayanon, Watid Kanchanawanichkul, Choosak Pripatnanont
Objective: To evaluate outcomes, biochemical recurrence-free survival (BCRFS) and to identify parameters influencing BCRFS of radical prostatectomy (RP) and bilateral pelvic lymph node dissection in a single-institution. Methods: A retrospective review of prostate cancer (PC) patients received RP was identified from the medical records. Data was collected from 2007 to 2016. 178 patients received RP were enrolled in a study. These patients were evaluated on efficacy of RP by using prostate-specific antigen (PSA) to analyze BCRFS and compared with Gleason score, pathologic staging, margin status and lymph node status with BCRFS...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28941924/risk-stratification-of-equivocal-pi-rads-lesions-in-mp-mri-of-the-prostate
#20
T Ullrich, M Quentin, C Arsov, A K Schmaltz, A Tschischka, N Laqua, A Hiester, D Blondin, R Rabenalt, P Albers, G Antoch, L Schimmöller
PURPOSE: To systematically analyze patients with PI-RADS-3-lesions (called 'equivocal' according to PI-RADS v2) in multiparametric prostate MRI (mp-MRI) and MR-targeted plus systematic transrectal ultrasound-guided (TRUS-GB) biopsies as reference standard. MATERIAL AND METHODS: One hundred and twenty consecutive patients with a PI-RADS overall score of 3 after mp-MRI (T2WI, DWI, DCE-MRI) at 3T and subsequent targeted MRI/US fusion-guided (FUS-GB) plus systematic 12-core TRUS-GB were retrospectively included in this study...
September 20, 2017: Journal of Urology
keyword
keyword
98250
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"