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https://www.readbyqxmd.com/read/27936191/a-scalable-data-access-layer-to-manage-structured-heterogeneous-biomedical-data
#1
Giovanni Delussu, Luca Lianas, Francesca Frexia, Gianluigi Zanetti
This work presents a scalable data access layer, called PyEHR, designed to support the implementation of data management systems for secondary use of structured heterogeneous biomedical and clinical data. PyEHR adopts the openEHR's formalisms to guarantee the decoupling of data descriptions from implementation details and exploits structure indexing to accelerate searches. Data persistence is guaranteed by a driver layer with a common driver interface. Interfaces for two NoSQL Database Management Systems are already implemented: MongoDB and Elasticsearch...
2016: PloS One
https://www.readbyqxmd.com/read/27935574/europium-doping-of-superparamagnetic-iron-oxide-nanoparticles-enables-their-detection-by-fluorescence-microscopy-and-for-quantitative-analytics
#2
Yuske Kobayashi, Ralf Hauptmann, Harald Kratz, Monika Ebert, Susanne Wagner, Matthias Taupitz
BACKGROUND: Pharmacokinetic studies and histological detection of superparamagnetic iron oxide nanoparticles (SPIO) in biomedical research are limited due to a high iron background especially in pathological tissues. OBJECTIVE: The suitability of doping the iron oxide cores of SPIO with europium (Eu) was tested for improved histologic detection and for quantitative analysis without changing their properties as probes for magnetic resonance imaging (MRI). A special variant of SPIO, so called very small superparamagnetic iron oxide nanoparticles (VSOP), was used for this approach...
December 2, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27931313/behavioral-effects-of-an-enhanced-enrichment-program-for-group-housed-sooty-mangabeys-cercocebus-atys
#3
Jessica Crast, Mollie A Bloomsmith, Trina J Jonesteller
Evaluating the behavioral effects of enrichment on animals housed in biomedical facilities is necessary to effectively support their care and wellbeing. We tested the cumulative effects of an enhanced enrichment program on sooty mangabey behavior: locomotion, feeding and foraging, manipulating items in the enclosure, social affiliation, aggression, and abnormal behavior. The enhanced enrichment program included the addition of a substrate (timothy hay), widely distributing small pieces of produce and a forage mixture in the hay, adding structures and perching, and increasing the variety of food items, foraging devices, and other manipulable items...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27925484/risk-factors-associated-with-repeated-hiv-testing-among-internet-using-men-who-have-sex-with-men
#4
Brent A Johnson, Jennie McKenney, Alexandra V Ricca, Eli S Rosenberg, Chang Liu, Akshay Sharma, Patrick S Sullivan
: Men who have sex with men (MSM) represent a disproportionately impacted risk group for HIV incidence among at-risk U.S. POPULATIONS: Few studies have identified risk factors associated with HIV testing frequency both within and outside of traditional health care settings. MSM enrolled in a prospective cohort were mailed at-home specimen collection kits and followed for a year. Incidence density rate ratios (IDRR) of testing were calculated, and generalized estimating equations were used to analyze the association between HIV testing and behavioral factors...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27924469/a-methylcellulose-and-collagen-based-temperature-responsive-hydrogel-promotes-encapsulated-stem-cell-viability-and-proliferation-in-vitro
#5
Christina Payne, Eimear B Dolan, Janice O'Sullivan, Sally-Ann Cryan, Helena M Kelly
With the number of stem cell-based therapies emerging on the increase, the need for novel and efficient delivery technologies to enable therapies to remain in damaged tissue and exert their therapeutic benefit for extended periods, has become a key requirement for their translation. Hydrogels, and in particular, thermoresponsive hydrogels, have the potential to act as such delivery systems. Thermoresponsive hydrogels, which are polymer solutions that transform into a gel upon a temperature increase, have a number of applications in the biomedical field due to their tendency to maintain a liquid state at room temperature, thereby enabling minimally invasive administration and a subsequent ability to form a robust gel upon heating to physiological temperature...
December 6, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27924157/biodegradable-nitrogen-doped-carbon-nanodots-for-non-invasive-photoacoustic-imaging-and-photothermal-therapy
#6
Changho Lee, Woosung Kwon, Songeun Beack, Donghyun Lee, Yoonsang Park, Hyemin Kim, Sei Kwang Hahn, Shi-Woo Rhee, Chulhong Kim
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability...
2016: Theranostics
https://www.readbyqxmd.com/read/27920900/polyelectrolyte-coating-on-superparamagnetic-iron-oxide-nanoparticles-as-interface-between-magnetic-core-and-biorelevant-media
#7
Etelka Tombácz, Katalin Farkas, Imre Földesi, Márta Szekeres, Erzsébet Illés, Ildikó Y Tóth, Daniel Nesztor, Tamás Szabó
Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to fulfil the expectation of medicine regulatory agencies and ultimately that of biocompatibility. In this work, we show the high surface reactivity of naked SPIONs due to ≡Fe-OH sites, which can react with H(+)/OH(-) to form pH- and ionic strength-dependent charges...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27917465/warm-reactive-immunoglobulin-g-autoantibodies-and-laboratory-testing-best-practices-review-of-the-literature-and-survey-of-current-practice
#8
REVIEW
Alyssa Ziman, Claudia Cohn, Patricia M Carey, Nancy M Dunbar, Mark K Fung, Andreas Greinacher, Simon Stanworth, Nancy M Heddle, Meghan Delaney
BACKGROUND: Warm-reactive autoantibodies (WAAs) are the most common cause of autoimmune hemolytic anemia (AIHA) and can also be present without clinically significant hemolysis. WAAs complicate immunohematological testing, yet there is no commonly accepted approach to laboratory evaluation and red blood cell (RBC) selection. STUDY DESIGN AND METHODS: We searched PubMed/Cochrane Central for articles that described testing methodology and blood selection for patients with WAAs...
December 4, 2016: Transfusion
https://www.readbyqxmd.com/read/27916691/therapeutic-effects-of-gold-nanoparticles-synthesized-using-musa-paradisiaca-peel-extract-against-multiple-antibiotic-resistant-enterococcus-faecalis-biofilms-and-human-lung-cancer-cells-a549
#9
S Vijayakumar, B Vaseeharan, B Malaikozhundan, N Gopi, P Ekambaram, R Pachaiappan, P Velusamy, K Murugan, G Benelli, R Suresh Kumar, M Suriyanarayanamoorthy
Botanical-mediated synthesis of nanomaterials is currently emerging as a cheap and eco-friendly nanotechnology, since it does not involve the use of toxic chemicals. In the present study, we focused on the synthesis of gold nanoparticles using the aqueous peel extract of Musa paradisiaca (MPPE-AuNPs) by green approach following a facile and cheap fabrication process. The green synthesized MPPE-AuNPs were bio-physically characterized by UV-Vis spectroscopy, FTIR, XRD, TEM, Zeta potential and EDX. MPPE-AuNPs were crystalline in nature, spherical to triangular in shape, with particle size ranged within 50 nm...
December 1, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27914328/synthesis-and-stability-of-ir-820-and-fitc-doped-silica-nanoparticles
#10
Atul V Thorat, Tandra Ghoshal, Lan Chen, Justin D Holmes, Michael A Morris
Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914268/anti-adhesive-antimicrobial-peptide-coating-prevents-catheter-associated-infection-in-a-mouse-urinary-infection-model
#11
Kai Yu, Joey C Y Lo, Mei Yan, Xiaoqiang Yang, Donald E Brooks, Robert E W Hancock, Dirk Lange, Jayachandran N Kizhakkedathu
Catheter-associated urinary tract infections (CAUTIs) represent one of the most common hospital acquired infections with significant economic consequences and increased patient morbidity. CAUTIs often start with pathogen adhesion and colonization on the catheter surface followed by biofilm formation. Current strategies to prevent CAUTIs are insufficiently effective and antimicrobial coatings based on antimicrobial peptides (AMPs) hold promise in curbing CAUTIs. Here we report an effective surface tethering strategy to prepare AMP coatings on polyurethane (PU), a common biomedical plastic used for catheter manufacture, by using an anti-adhesive hydrophilic polymer coating...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27914264/pattern-based-sensing-of-triple-negative-breast-cancer-cells-with-dual-ligand-cofunctionalized-gold-nanoclusters
#12
Yu Tao, Mingqiang Li, Debra T Auguste
Early detection of breast cancer is a critical component in patient prognosis and establishing effective therapy regimens. Here, we developed an easily accessible yet potentially powerful sensor to detect cancer cell targets by utilizing seven dual-ligand cofunctionalized gold nanoclusters (AuNCs) as both effective cell recognition elements and signal transducers. On the basis of this AuNC multichannel sensor, we have successfully distinguished healthy, cancerous and metastatic human breast cells with excellent reproducibility and high sensitivity...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27912961/the-effect-of-chinese-herbal-medicine-on-hemorrhagic-shock-a-systematic-review-and-meta-analysis
#13
REVIEW
Da-Long Wang, Xiao-Guang Lu, Wen-Xiu Guo, Tuo Chen, Yi Song, Zhi-Wei Fan
BACKGROUND: Chinese herbal medicine (CHM) has been widely used in the treatment of hemorrhagic shock (HS) in China. Many controlled trials have been undertaken to investigate its efficacy. OBJECTIVE: To evaluate the effectiveness and safety of CHM for Hemorrhagic Shock patients. METHODS: We screening the Web of ScienceDirect database, PubMed, the Cochrane Library, EMBASE, China Biomedical Database web (CBM), China National Knowledge Infrastructure (CNKI) and WanFang database (WF), from inception to January 2015...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27905986/predictors-of-perceived-male-partner-concurrency-among-women-at-risk-for-hiv-and-sti-acquisition-in-durban-south-africa
#14
Zakir Gaffoor, Handan Wand, Renée A Street, Nathlee Abbai, Gita Ramjee
BACKGROUND: Women in sub-Saharan Africa continue to be at greater risk for HIV acquisition than men. Concurrency, viz. multiple sexual partnerships that overlap over time, has been studied as a possible risk factor for HIV transmission. The aim of this study was to identify predictors of perceived male partner concurrency among sexually active, HIV negative women. METHODS: Socio-demographic and behavioural data from women enrolled in a biomedical HIV prevention clinical trial were assessed in relation to perceived male partner concurrency using the Chi squared test...
March 8, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27896946/dynamic-laser-speckle-angiography-achieved-by-eigen-decomposition-filtering
#15
Chenxi Li, Ruikang Wang
A new approach is proposed for statistically analysis of laser speckle signals emerged from a living biological tissue based on eigen-decomposition to separate the dynamic speckle signals due to moving blood cells from the static speckle signals due to static tissue components, upon which to achieve angiography of the interrogated tissue in vivo. The proposed approach is tested by imaging mouse ear pinna in vivo, demonstrating its capability of providing detailed microvascular networks with high contrast, and high temporal and spatial resolutions...
November 29, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27893379/blasst-band-limited-atomic-sampling-with-spectral-tuning-with-applications-to-utility-line-noise-filtering
#16
Kenneth R Ball, W David Hairston, Piotr J Franaszczuk, Kay A Robbins
OBJECTIVE: In this paper we present and test a new method for the identification and removal of non-stationary utility line noise from biomedical signals. METHODS: The method, Band Limited Atomic Sampling with Spectral Tuning (BLASST), is an iterative approach that is designed to (1) fit non-stationarities in line noise by searching for best-fit Gabor atoms at predetermined time points, (2) self-modulate its fit by leveraging information from frequencies surrounding the target frequency, and (3) terminate based on a convergence criterion obtained from the same surrounding frequencies...
November 23, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27892435/awareness-knowledge-and-practices-of-dental-waste-management-among-private-practitioners
#17
K N Abhishek, S Supreetha, N Varma Penumatsa, G Sam, S C Khanapure, S Sivarajan
Background Dental wastes are materials that have been utilized in dental clinics, which are no longer wanted for use and therefore discarded. Improper disposal of these dental wastes can cause harm to the dentist, the people in immediate vicinity of the dentist. Objective The present study was conducted to assess the knowledge and practices regarding Dental waste management among private practitioners. Method The study population included 186 private practitioners in three districts of Karnataka (Coorg, Mysore, Hassan), south India...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27890802/highly-water-absorbing-silk-yarn-with-interpenetrating-network-via-in-situ-polymerization
#18
Ka I Lee, Xiaowen Wang, Xia Guo, Ka-Fu Yung, Bin Fei
Silk was modified via in situ polymerization of two monomers acrylamide and sodium acrylate by swelling in an effective LiBr dissolution system. Swelling of natural silks in LiBr solutions of low concentration was clearly observed under optical microscope, and their conformational changes were revealed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Dissolution tests and FTIR spectra of these modified silks suggested the presence of interpenetrating network of polyacrylamide and poly(sodium acrylate) in the silk yarns...
November 24, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27886563/nanomechanical-properties-wear-resistance-and-in-vitro-characterization-of-ta2o5-nanotubes-coating-on-biomedical-grade-ti-6al-4v
#19
Masoud Sarraf, Bushroa Abdul Razak, Bahman Nasiri-Tabrizi, Ali Dabbagh, Noor Hayaty Abu Kasim, Wan Jefrey Basirun, Eshamsul Bin Sulaiman
Tantalum pentoxide nanotubes (Ta2O5 NTs) can dramatically raise the biological functions of different kinds of cells, thus have promising applications in biomedical fields. In this study, Ta2O5 NTs were prepared on biomedical grade Ti-6Al-4V alloy (Ti64) via physical vapor deposition (PVD) and a successive two-step anodization in H2SO4: HF (99:1)+5% EG electrolyte at a constant potential of 15V. To improve the adhesion of nanotubular array coating on Ti64, heat treatment was carried out at 450°C for 1h under atmospheric pressure with a heating/cooling rate of 1°Cmin(-)(1)...
November 16, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27886562/magnetic-susceptibility-artifact-volume-in-mri-and-tensile-properties-of-swaged-zr-ag-composites-for-biomedical-applications
#20
Haruki Imai, Yoji Tanaka, Naoyuki Nomura, Hisashi Doi, Yusuke Tsutsumi, Takashi Ono, Takao Hanawa
Zr-Ag composites were fabricated to decrease the magnetic susceptibility by compensating for the magnetic susceptibility of their components. The Zr-Ag composites with a different Zr-Ag ratio were swaged, and their magnetic susceptibility, artifact volume, and mechanical properties were evaluated by magnetic balance, three-dimensional (3-D) artifact rendering, and a tensile test, respectively. These properties were correlated with the volume fraction of Ag using the linear rule of mixture. We successfully obtained the swaged Zr-Ag composites up to the reduction ratio of 96% for Zr-4, 16, 36, 64Ag and 86% for Zr-81Ag...
November 12, 2016: Journal of the Mechanical Behavior of Biomedical Materials
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