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https://www.readbyqxmd.com/read/29334612/tempo-oxidized-bacterial-cellulose-pellicle-with-silver-nanoparticles-for-wound-dressing
#1
Chun-Nan Wu, Shih-Chang Fuh, Shin-Ping Lin, Yen-Yi Lin, Hung-Yueh Chen, Jui-Ming Liu, Kuan-Chen Cheng
Biocompatible bacterial cellulose pellicle (BCP) is a candidate for biomedical material such as wound dressing. However, due to lack of antibacterial activity, to grant BCP with the property is crucial for its biomedical application. In the present study, BCP was modified by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation using TEMPO/NaClO/NaBr system at pH 10 to form TEMPO-oxidized BCP (TOBCP) with anionic C6 carboxylate groups. The TOBCP was subsequently ion-exchanged in AgNO3 solution and silver nanoparticles (AgNP) with diameter of ~16...
January 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29333931/hyperspectral-imaging-of-tissue-perfusion-and-oxygenation-in-wounds-assessing-the-impact-of-a-micro-capillary-dressing
#2
Thomas Wild, Markus Becker, Jochen Winter, Nicole Schuhschenk, Georg Daeschlein, Frank Siemers
OBJECTIVE: Experimental tests of non-invasive multi- or hyperspectral imaging (HSI) systems reveal the high potential of support for medical diagnostic purposes and scientific biomedical analysis. Until now the use of HSI technologies for medical applications was limited by complex and overly sophisticated systems. We present a new and compact HSI-camera that could be used in normal clinical practice. METHOD: We assessed the use of the HSI system on the hands of 10 healthy volunteers, looking at control parameters, and those following venous occlusion, arterial occlusion and reperfusion, including tissue oxygenation, tissue haemoglobin index, perfusion in 4-6mm depth=near infrared spectroscopy (NIR), and tissue water index...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333051/therapeutic-significance-of-loligo-vulgaris-lamarck-1798-ink-extract-a-biomedical-approach
#3
Sri Kumaran Nadarajah, Radha Vijayaraj, Jayaprakashvel Mani
Background: The squid ink extract is well known for its biomedical properties. Objective: In this study, squid Loligo vulgaris was collected from Tuticorin costal water, Bay of Bengal, India. Materials and Methods: Proximate composition of the crude squid ink was studied and found to have protein as the major component over lipid and carbohydrates. Further, bioactive fractions of squid ink were extracted with ethanol, and therapeutic applications such as hemolytic, antioxidant, antimicrobial, and in vitro anti-inflammatory properties were analyzed using standard methods...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332986/fadttster-accelerating-hypothesis-testing-with-functional-analysis-of-diffusion-tensor-tract-statistics
#4
Jean Noel, Juan C Prieto, Martin Styner
Functional Analysis of Diffusion Tensor Tract Statistics (FADTTS) is a toolbox for analysis of white matter (WM) fiber tracts. It allows associating diffusion properties along major WM bundles with a set of covariates of interest, such as age, diagnostic status and gender, and the structure of the variability of these WM tract properties. However, to use this toolbox, a user must have an intermediate knowledge in scripting languages (MATLAB). FADTTSter was created to overcome this issue and make the statistical analysis accessible to any non-technical researcher...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29324741/facilitating-healthcare-decisions-by-assessing-the-certainty-in-the-evidence-from-preclinical-animal-studies
#5
Carlijn R Hooijmans, Rob B M de Vries, Merel Ritskes-Hoitinga, Maroeska M Rovers, Mariska M Leeflang, Joanna IntHout, Kimberley E Wever, Lotty Hooft, Hans de Beer, Ton Kuijpers, Malcolm R Macleod, Emily S Sena, Gerben Ter Riet, Rebecca L Morgan, Kristina A Thayer, Andrew A Rooney, Gordon H Guyatt, Holger J Schünemann, Miranda W Langendam
Laboratory animal studies are used in a wide range of human health related research areas, such as basic biomedical research, drug research, experimental surgery and environmental health. The results of these studies can be used to inform decisions regarding clinical research in humans, for example the decision to proceed to clinical trials. If the research question relates to potential harms with no expectation of benefit (e.g., toxicology), studies in experimental animals may provide the only relevant or controlled data and directly inform clinical management decisions...
2018: PloS One
https://www.readbyqxmd.com/read/29324696/quantitative-assessment-of-antimicrobial-activity-of-plga-films-loaded-with-4-hexylresorcinol
#6
Michael Kemme, Regina Heinzel-Wieland
Profound screening and evaluation methods for biocide-releasing polymer films are crucial for predicting applicability and therapeutic outcome of these drug delivery systems. For this purpose, we developed an agar overlay assay embedding biopolymer composite films in a seeded microbial lawn. By combining this approach with model-dependent analysis for agar diffusion, antimicrobial potency of the entrapped drug can be calculated in terms of minimum inhibitory concentrations (MICs). Thus, the topical antiseptic 4-hexylresorcinol (4-HR) was incorporated into poly(lactic-co-glycolic acid) (PLGA) films at different loadings up to 3...
January 11, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29323901/microbial-biosynthesis-of-silver-nanoparticles-in-different-culture-media
#7
Ke Luo, Samuel Jung, Kyu-Hwan Park, Young-Rok Kim
Microbial biosynthesis of metal nanoparticles has been extensively studied for the applications in biomedical sciences and engineering. However, the mechanism for their synthesis through microorganism is not completely understood. In this study, several culture media were investigated for their roles in the microbial biosynthesis of silver nanoparticles (AgNPs). The size and morphology of the synthesized AgNPs were analyzed by UV-Vis spectroscopy, FT-IR, TEM, and DLS. The results demonstrated that nutrient broth (NB) and Mueller-Hinton broth (MHB) among tested media effectively reduced silver ions to form AgNPs with different particle size and shape...
January 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29322517/discordant-human-t-lymphotropic-virus-screening-with-western-blot-confirmation-evaluation-of-the-dual-test-algorithm-for-us-blood-donations
#8
Susan L Stramer, Rebecca L Townsend, Gregory A Foster, Ramona Johnson, Barbara Weixlmann, Roger Y Dodd
BACKGROUND: Human T-lymphotropic virus (HTLV) blood donation screening has used a dual-testing algorithm beginning with either a chemiluminescent immunoassay or enzyme-linked immunosorbent screening assay (ELISA). Before the availability of a licensed HTLV supplemental assay, repeat-reactive (RR) samples on a first assay (Assay 1) were retested with a second screening assay (Assay 2). Donors with RR results by Assay 2 were deferred from blood donation and further tested using an unlicensed supplemental test to confirm reactivity while nonreactive (NR) donors remained eligible for donation until RR on a subsequent donation...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29320725/keratin-based-bioplastic-film-from-chicken-feathers-and-its-characterization
#9
Navina Ramakrishnan, Swati Sharma, Arun Gupta, Basma Yahya Alashwal
Plastics have been one of the highly valued materials and it plays an significant role in human's life such as in food packaging and biomedical applications. Bioplastic materials can gradually work as a substitute for various materials based on fossil oil. The issue like sustainability and environmental challenges which occur due to manufacturing and disposal of synthetic plastics can be conquering by bio-based plastics. Feathers are among the most inexpensive abundant, and renewable protein sources. Feathers disposal to the landfills leads to environmental pollutions and it results into wastage of 90% of protein raw material...
January 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29318557/ear-sponge-assay-a-method-to-investigate-angiogenesis-and-lymphangiogenesis-in-mice
#10
Maureen Van de Velde, Melissa García-Caballero, Tania Durré, Frédéric Kridelka, Agnès Noël
Angiogenesis and lymphangiogenesis have become important research areas in the biomedical field. The outgrowth of new blood (angiogenesis) and lymphatic (lymphangiogenesis) vessels from preexisting ones is involved in many pathologies including cancer. In-depth investigations of molecular determinants such as proteases in these complex processes require reliable in vivo models. Here we present the ear sponge assay as an easy, rapid, quantitative and reproducible model of angiogenesis and lymphangiogenesis. In this system, a gelatin sponge soaked with tumor cells, cell-conditioned medium, or a compound to be tested is implanted, for 2-4 weeks, between the two mouse ear skin layers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29317809/best-strategies-to-recruit-and-enroll-elderly-blacks-into-clinical-and-biomedical-research
#11
Lennox A Graham, Julius Ngwa, Oyonumo Ntekim, Oludolapo Ogunlana, Saba Wolday, Steven Johnson, Megan Johnson, Chimene Castor, Thomas V Fungwe, Thomas O Obisesan
Background: Historically, Blacks have been disproportionately underrepresented in clinical trials. Outcomes associated with low Blacks' participation in research include poor understanding of the predictors and treatment of the disease, increasing health disparities, poor health equity, and suboptimal wellness of the nation as a whole. To address this gap in research participation, we analyzed our recruitment data to identify the most effective strategies for enrolling older Blacks in clinical trials...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29316706/assessing-the-performances-of-protein-function-prediction-algorithms-from-the-perspectives-of-identification-accuracy-and-false-discovery-rate
#12
Chun Yan Yu, Xiao Xu Li, Hong Yang, Ying Hong Li, Wei Wei Xue, Yu Zong Chen, Lin Tao, Feng Zhu
The function of a protein is of great interest in the cutting-edge research of biological mechanisms, disease development and drug/target discovery. Besides experimental explorations, a variety of computational methods have been designed to predict protein function. Among these in silico methods, the prediction of BLAST is based on protein sequence similarity, while that of machine learning is also based on the sequence, but without the consideration of their similarity. This unique characteristic of machine learning makes it a good complement to BLAST and many other approaches in predicting the function of remotely relevant proteins and the homologous proteins of distinct function...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315997/systematic-review-and-meta-analysis-of-the-associations-between-maternal-methylenetetrahydrofolate-reductase-polymorphisms-and-preterm-delivery
#13
Qiwen Fang, Yixuan Jiang, Zhenqiu Liu, Zhijie Zhang, Tiejun Zhang
AIM: To date, reported associations between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and preterm delivery are conflicting. The present meta-analysis summarized the existing evidence and evaluated these associations. METHODS: Eligible studies were retrieved from Medline (PubMed), EMBASE, the Chinese Biomedical Literature Database and the Cochrane Library. We calculated pooled odds ratios (ORs) and 95% confidence interval (CIs) within five genetic models using either random-effects or fixed-effects models dependent on study heterogeneity...
January 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29314658/comparative-assessment-of-five-trials-of-universal-hiv-testing-and-treatment-in-sub-saharan-africa
#14
REVIEW
Delphine Perriat, Laura Balzer, Richard Hayes, Shahin Lockman, Fiona Walsh, Helen Ayles, Sian Floyd, Diane Havlir, Moses Kamya, Refeletswe Lebelonyane, Lisa A Mills, Velephi Okello, Maya Petersen, Deenan Pillay, Kalpana Sabapathy, Kathleen Wirth, Joanna Orne-Gliemann, François Dabis
DESIGN: Universal voluntary HIV counselling and testing followed by prompt initiation of antiretroviral therapy (ART) for all those diagnosed HIV-infected (universal test and treat, UTT) is now a global health standard. However, its population-level impact, feasibility and cost remain unknown. Five community-based trials have been implemented in sub-Saharan Africa to measure the effects of various UTT strategies at population level: BCPP/YaTsie in Botswana, MaxART in Swaziland, HPTN 071 (PopART) in South Africa and Zambia, SEARCH in Uganda and Kenya and ANRS 12249 TasP in South Africa...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29310434/in-vitro-and-in-vivo-studies-on-biomedical-magnesium-low-alloying-with-elements-gadolinium-and-zinc-for-orthopaedic-implant-applications
#15
Dong Bian, Jiuxu Deng, Nan Li, Xiao Chu, Yang Liu, Wenting Li, Hong Cai, Peng Xiu, Yu Zhang, Zhenpeng Guan, Yufeng Zheng, Yuhui Kou, Baoguo Jiang, Rongshi Chen
Ternary magnesium alloys with low combined-addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors and cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, with the best in vitro performances, was implanted into Sprague Dawley rats to examine its in vivo degradation performances up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX®, the mischmetal added Mg alloy...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29307755/antibacterial-and-antioxidant-potentials-of-non-cytotoxic-extract-of-trichoderma-atroviride
#16
Kandasamy Saravanakumar, Ramachandran Chelliah, Sudha Rani Ramakrishnan, Kandasamy Kathiresan, Deog-Hwan Oh, Myeong-Hyeon Wang
Trichoderma species are a rich source of metabolites, but less known for biomedical potential. This work deals with antibacterial and antioxidant potentials of intracellular non-cytotoxic metabolites, extracted from Trichoderma atroviride (KNUP001). A total of 53 fractions was collected by column chromatography and tested for cytotoxicity by MTT assay. Only one fraction (F41) was found to be non-toxic to Vero cells with 95.4 ± 0.61% of survival. The F41 was then subjected to chemical analysis, antibacterial and antioxidant assays...
January 4, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29306080/hybrid-micro-nanostructural-surface-offering-improved-stress-distribution-and-enhanced-osseointegration-properties-of-the-biomedical-titanium-implant
#17
Ping-Jen Hou, Keng-Liang Ou, Chin-Chieh Wang, Chiung-Fang Huang, Muhammad Ruslin, Erwan Sugiatno, Tzu-Sen Yang, Hsin-Hua Chou
OBJECTIVES: The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. MATERIALS AND METHODS: The surface characteristic, biomechanical behavior and hemocompatibility of the MST-Ti dental implant were performed using scanning electron microscope, finite element method, blood dripping and immersion tests...
November 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29301357/novel-blend-for-producing-porous-chitosan-based-films-suitable-for-biomedical-applications
#18
Norhan Nady, Sherif H Kandil
In this work, a chitosan-gelatin-ferulic acid blend was used in different ratios for preparing novel films that can be used in biomedical applications. Both acetic and formic acid were tested as solvents for the chitosan-gelatin-ferulic acid blend. Glycerol was tested as a plasticizer. The thickness, mechanical strength, static water contact angle and water uptake of the prepared films were determined. Also, the prepared films were characterized using different analysis techniques such as Fourier transform infrared spectroscopy (FT-IR) analysis, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM)...
January 3, 2018: Membranes
https://www.readbyqxmd.com/read/29297394/appropriateness-and-timeliness-of-care-seeking-for-complications-of-pregnancy-and-childbirth-in-rural-ethiopia-a-case-study-of-the-maternal-and-newborn-health-in-ethiopia-partnership
#19
Lynn M Sibley, Yared Amare, Solomon Tesfaye Abebe, Mulusew Lijalem Belew, Kemeredin Shiffra, Danika Barry
BACKGROUND: In 2014, USAID and University Research Co., LLC, initiated a new project under the broader Translating Research into Action portfolio of projects. This new project was entitled Systematic Documentation of Illness Recognition and Appropriate Care Seeking for Maternal and Newborn Complications. This project used a common protocol involving descriptive mixed-methods case studies of community projects in six low- and middle-income countries, including Ethiopia. In this paper, we present the Maternal and Newborn Health in Ethiopia Partnership (MaNHEP) case study...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29285899/design-of-polymeric-culture-substrates-to-promote-proangiogenic-potential-of-stem-cells
#20
REVIEW
Byeong-Ju Kwon, Xintong Wang, Mi-Lan Kang, Jin You, Shin-Jeong Lee, Won Shik Kim, Young-Sup Yoon, Jong-Chul Park, Hak-Joon Sung
Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities...
December 29, 2017: Macromolecular Bioscience
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